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https://www.readbyqxmd.com/read/28229270/should-the-annulus-be-fixed-in-aortic-valve-sparing-root-replacement-with-remodeling
#1
Kojiro Furukawa, Keiji Kamohara, Junji Yunoki, Shugo Koga, Manabu Itoh, Hiroyuki Morokuma, Yosuke Mukae, Tsuyoshi Itoh, Shigeki Morita
OBJECTIVES: If the aortic root dilates after native aortic valve-sparing root reconstruction with remodeling, aortic regurgitation may recur. However, it has not been demonstrated clearly that the aortic root dilates after remodeling. METHODS: This study enrolled 15 patients who underwent an aortic valve-sparing operation with remodeling (2002-2014) but without any ventriculo-aortic junction (VAJ) fixation. Technically, special care was taken to pass the sutures through the fibrous annulus...
February 22, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28228313/significant-intra-valvular-pressure-loss-across-epic-supra-and-perimount-magna-supra-annular-designed-aortic-bioprostheses-in-patients-with-normal-aortic-size
#2
Jagdish C Mohan, Vishwas Mohan, Madhu Shukla, Arvind Sethi
Doppler-derived trans-prosthetic gradients are higher and the estimated effective valve area is smaller than the catheter-derived and directly measured hemodynamic values, mostly due to pressure recovery phenomenon. Pressure recovery to a varying extent is common to all prosthetic heart valves including bioprostheses. Pressure recovery-related differences are usually small except in patients with bileaflet metallic prosthesis, wherein high-pressure local jets across central orifice have been documented since long back and also in patients with narrow aortic root...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28227464/the-effect-of-the-aortic-valve-orientation-on-cavitation
#3
Peter Johansen, Brandon R Travis, Morten Smerup, Thomas Decker Christensen, Jonas Funder, Camilla Nyboe, Hans Nygaard, J Michael Hasenkam, Peter Johansen, Brandon R Travis, Morten Smerup, Thomas Decker Christensen, Jonas Funder, Camilla Nyboe, Hans Nygaard, J Michael Hasenkam, Brandon R Travis, Peter Johansen, Hans Nygaard, Morten Smerup, Jonas Funder, Camilla Nyboe, Thomas Decker Christensen, J Michael Hasenkam
When implanting a mechanical aortic valve the annulus orientation is important with respect to turbulence. However, the effect on cavitation has not yet been investigated. The aim of this study was to investigate how cavitation is influenced hereof in vivo. Three pigs were included in the study. An Omnicarbon 21mm valve equipped with a rotating mechanism enabling controlled rotation of the valve was implanted in aortic position. Under stable hemodynamic conditions, measurements were performed using a hydrophone positioned at the aortic root...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227216/prediction-of-individual-prosthesis-size-for-valve-sparing-aortic-root-reconstruction-based-on-geometric-features
#4
J Hagenah, E Werrmann, M Scharfschwerdt, F Ernst, C Metzner, J Hagenah, E Werrmann, M Scharfschwerdt, F Ernst, C Metzner, C Metzner, E Werrmann, J Hagenah, F Ernst, M Scharfschwerdt
Valve-sparing aortic root reconstruction is an up- and-coming approach for patients suffering from aortic valve insufficiencies which promises to significantly reduce complications. However, the success of the treatment strongly depends on the challenging task of choosing the correct size of the prosthesis, for which, up to now, surgeons solely have to rely on their experience. Here, we present a novel machine learning based approach, which might make it possible to predict the size of the prosthesis from pre-operatively acquired ultrasound images...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215318/dietary-corn-fractions-reduce-atherogenesis-in-low-density-lipoprotein-receptor-knockout-mice
#5
Kabo Masisi, Khuong Le, Nora Ghazzawi, Mohammed H Moghadasian, Trust Beta
Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate intake of corn fractions (aleurone, endosperm and germ) can modify lipid profiles in relation to atherosclerotic lesion development in low-density lipoprotein receptor knockout (LDLr-KO) mice. The purpose of the present study was to investigate the potential cardiovascular benefits of corn fractions in LDLr-KO mice through a number of biomarkers including lipid profile, and morphologic and morphometrical analysis of atherosclerotic lesions in aortic root...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28212738/delayed-efficacy-of-radiofrequency-catheter-ablation-on-ventricular-arrhythmias-originating-from-the-left-ventricular-anterobasal-wall
#6
Ligang Ding, Bingbo Hou, Lingmin Wu, Yu Qiao, Wei Sun, Jinrui Guo, Lihui Zheng, Gang Chen, Linfeng Zhang, Shu Zhang, Yan Yao
BACKGROUND: Ventricular arrhythmias (VAs) originating from the left ventricular anterobasal wall (LV-ABW) may represent a therapeutic challenge. OBJECTIVE: The purpose of this study was to investigate the delayed efficacy of radiofrequency catheter (RFCA) ablation without an epicardial approach on VAs originating from the LV-ABW. METHODS: Eighty patients (mean age 46.9 ± 14.9 years; 47 male) with VAs originating from the LV-ABW were enrolled...
March 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28209770/are-patients-with-loeys-dietz-syndrome-misdiagnosed-with-beals-syndrome
#7
Rebecca Woolnough, Andrew Dhawan, Kimberly Dow, Jagdeep S Walia
Beals syndrome, also known as congenital contractural arachnodactyly (Online Mendelian Inheritance in Man: 121050), is an autosomal dominant disorder caused by a mutation in FBN2 that is typically characterized by congenital contractures and arachnodactyly. It shares a number of phenotypic features with Loeys-Dietz syndrome (Online Mendelian Inheritance in Man: 609192). Loeys-Dietz syndrome, initially described in 2005, is associated with mutations for the transforming growth factor β receptor and is characterized by findings of cerebral, thoracic, and abdominal arterial aneurysms...
February 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28203207/morphotype-dependent-flow-characteristics-in-bicuspid-aortic-valve-ascending-aortas-a-benchtop-particle-image-velocimetry-study
#8
Andrew McNally, Ashish Madan, Philippe Sucosky
The bicuspid aortic valve (BAV) is a major risk factor for secondary aortopathy such as aortic dilation. The heterogeneous BAV morphotypes [left-right-coronary cusp fusion (LR), right-non-coronary cusp fusion (RN), and left-non-coronary cusp fusion (LN)] are associated with different dilation patterns, suggesting a role for hemodynamics in BAV aortopathogenesis. However, assessment of this theory is still hampered by the limited knowledge of the hemodynamic abnormalities generated by the distinct BAV morphotypes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28201842/minimally-invasive-aortic-root-replacement-with-valved-conduits-through-partial-upper-sternotomy
#9
Julia Hillebrand, Mosab Alshakaki, Sven Martens, Mirela Scherer
Background Minimally invasive surgical access through limited sternotomy reduces trauma and morbidity in cardiosurgical patients. However, until now, it is not the standard access for aortic root replacement. This study details our clinic's experience with minimally invasive implantation of valved conduits through partial upper sternotomy and the comparison to conventional full median sternotomy. Methods Between January 2012 and March 2016, a total of 187 patients underwent aortic root replacement with valved conduits in our department...
February 15, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28198045/composite-graft-using-an-edwards-intuity-elite-rapid-deployment-bioprosthesis-for-aortic-root-replacement
#10
Marco Gennari, Marco Agrifoglio, Gianluca Polvani
We describe a technique using an Edwards Intuity Elite rapid deployment bioprosthesis to construct a composite graft for an aortic root replacement.
February 15, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28191682/aortic-root-thrombus-complicated-by-left-main-coronary-artery-occlusion-visualized-by-3d-echocardiography-in-a-patient-with-continuous-flow-left-ventricular-assist-device
#11
Monique S Tanna, Alex Reyentovich, Leora B Balsam, John A Dodson, Alan F Vainrib, Ricardo J Benenstein, Barry P Rosenzweig, Muhamed Saric
Aortic root thrombus is an uncommon complication of continuous-flow left ventricular assist devices (LVAD). We present the case of a 71-year-old man with ischemic cardiomyopathy who underwent destination therapy HeartMate II LVAD placement. Eighteen months later, he presented with a cerebrovascular accident followed by myocardial infarction. Transesophageal echocardiography revealed an aortic root thrombus spanning the left and noncoronary cusps and obliterating the left main coronary artery. We discuss the incidence, risk factors, and management of aortic root thrombus in LVAD patients...
February 13, 2017: Echocardiography
https://www.readbyqxmd.com/read/28190607/patient-specific-assessment-of-hemodynamics-by-computational-fluid-dynamics-in-patients-with-bicuspid-aortopathy
#12
Naoyuki Kimura, Masanori Nakamura, Kenji Komiya, Satoshi Nishi, Atsushi Yamaguchi, Osamu Tanaka, Yoshio Misawa, Hideo Adachi, Koji Kawahito
OBJECTIVE: Hemodynamics related to eccentric blood flow may factor into the development of bicuspid aortic valve aortopathy. We investigated wall shear stress distribution by means of magnetic resonance imaging-based computational fluid dynamics in patients with a bicuspid aortic valve. METHODS: Included were 12 patients with a bicuspid aortic valve (aortic stenosis, n = 11; root enlargement, n = 1). Three patients with a normal tricuspid aortic valve (arch aneurysm, n = 1; descending aortic aneurysm, n = 2) were included for comparison...
January 11, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28188661/idiopathic-epicardial-ventricular-tachycardia-from-the-coronary-venous-system-from-electrocardiographic-recognition-to-appropriate-therapy
#13
Stéphane Boulé, Claire Federspiel, Eric Verbrugge, Didier Klug
Idiopathic epicardial ventricular tachycardias (VTs) account for 9% of idiopathic VTs. The recognition of this entity is important, as a minimally invasive ablation procedure performed exclusively through the coronary sinus branches may be considered, avoiding the potential risks associated with access to the left ventricular endocardium, the aortic root, and the pericardial space. The electrocardiographic features and therapeutic management of this rare form of tachycardia are discussed.
February 11, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28188022/interplay-between-hsp90-and-nrf2-pathways-in-diabetes-associated-atherosclerosis
#14
Iolanda Lazaro, Ainhoa Oguiza, Carlota Recio, Laura Lopez-Sanz, Susana Bernal, Jesus Egido, Carmen Gomez-Guerrero
INTRODUCTION: Oxidative stress and inflammation are determinant processes in the development of diabetic vascular complications. Heat shock protein 90 (HSP90) overexpression in atherosclerotic plaques plays a role in sustaining inflammatory mechanisms, and its specific inhibition prevents atherosclerosis. The present work investigates, in a mouse model of diabetes-driven atherosclerosis, whether atheroprotection by pharmacological HSP90 inhibition is accomplished by bolstering antioxidant defense mechanisms headed by nuclear factor erythroid-derived 2-like 2 (Nrf2)...
February 7, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28187973/remodeling-root-repair-with-an-external-aortic-ring-annuloplasty
#15
Emmanuel Lansac, Isabelle Di Centa, Ghassan Sleilaty, Stephanie Lejeune, Alain Berrebi, Pavel Zacek, Mathieu Debauchez
OBJECTIVE: Although the remodeling technique provides the most dynamic valve-sparing root replacement, a dilated annulus (>25 mm) is a risk factor for failure. Aortic annuloplasty aims to reduce the annulus diameter, thus increasing coaptation height to protect the repair. The results of 177 patients with remodeling and external aortic ring annuloplasty were studied. METHODS: Data were collected from the Aortic Valve repair InternATiOnal Registry. Preoperative aortic insufficiency grade 3 or greater was present in 79 patients (44...
January 11, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28186292/reoperations-versus-primary-operation-on-the-aortic-root-a-propensity-score-analysis
#16
Paolo Berretta, Luca Di Marco, Davide Pacini, Mariano Cefarelli, Jacopo Alfonsi, Sebastiano Castrovinci, Marco Di Eusanio, Roberto Di Bartolomeo
No abstract text is available yet for this article.
February 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28186283/early-clinical-outcome-after-aortic-root-replacement-using-a-biological-composite-valved-graft-with-and-without-neo-sinuses
#17
Mario Gaudino, Luca Weltert, Monica Munjal, Christopher Lau, Mohamed Elsayed, Andrea Salica, Ivancarmine Gambardella, Erin Mills, Ruggero De Paulis, Leonard N Girardi
No abstract text is available yet for this article.
February 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28185849/sex-differences-in-the-aortic-root-size-implications-for-tavr
#18
EDITORIAL
Jonathon Leipsic, Stephanie Sellers, Philipp Blanke
No abstract text is available yet for this article.
February 1, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28181012/oral-administration-of-the-lactic-acid-bacterium-pediococcus-acidilactici-attenuates-atherosclerosis-in-mice-by-inducing-tolerogenic-dendritic-cells
#19
Taiji Mizoguchi, Kazuyuki Kasahara, Tomoya Yamashita, Naoto Sasaki, Keiko Yodoi, Takuya Matsumoto, Takuo Emoto, Tomohiro Hayashi, Naoki Kitano, Naofumi Yoshida, Hilman Zulkifli Amin, Ken-Ichi Hirata
The intestinal microbiota appears to play an important role in the development of atherosclerosis. We investigated the effect of the probiotic lactic acid bacterium Pediococcus acidilactici R037 on atherosclerosis using apolipoprotein E-deficient (ApoE (-/-)) mice. Six-week-old ApoE (-/-) mice were orally administered R037 six times a week. Mice treated with R037 for 12 weeks exhibited markedly attenuated atherosclerotic lesions in the aortic root (2.3 ± 0.15 × 10(5) µm(2) vs. 3.3 ± 0.29 × 10(5) µm(2), respectively; P < 0...
February 8, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28177681/icariin-improves-enos-no-pathway-to-prohibit-the-atherogenesis-of-apolipoprotein-e-null-mice
#20
Hong-Bo Xiao, Guo-Guang Sui, Xiang-Yang Lu
Impaired endothelial nitric oxide synthesis (eNOS) / nitric oxide (NO) pahtway induce the atherogenesis. The present study examined whether icariin improves the eNOS / NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE-/-) mice. In vitro, primary human umbilical vein endothelial cells (HUVECs) were randomly divided into 7 groups: control, vehicle; icariin 10; LPC group; LPC + icariin 1; LPC + icariin 3; LPC + icariin 10. In vivo, 80 mice were separated randomly into four groups (n = 20): control, ApoE-/- , ApoE-/- + icariin 10, and ApoE-/- + icariin 30...
December 22, 2016: Canadian Journal of Physiology and Pharmacology
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