Maria Grandoch, Kathrin Feldmann, Joachim R Göthert, Lena S Dick, Susanne Homann, Christina Klatt, Julia K Bayer, Jan N Waldheim, Berit Rabausch, Nadine Nagy, Alexander Oberhuber, René Deenen, Karl Köhrer, Stefan Lehr, Bernhard Homey, Klaus Pfeffer, Jens W Fischer
RATIONALE: Lymphotoxin β receptor (LTbR) regulates immune cell trafficking and communication in inflammatory diseases. However, the role of LTbR in atherosclerosis is still unclear. OBJECTIVE: The aim of this study was to elucidate the role of LTbR in atherosclerosis. METHODS AND RESULTS: After 15 weeks of feeding a Western-type diet, mice double-deficient in apolipoprotein E and LTbR (apoE(-/-)/LTbR(-/-)) exhibited lower aortic plaque burden than did apoE(-/-) littermates...
April 10, 2015: Circulation Research