Cassandra B Higgins, Joshua A Adams, Matthew H Ward, Zev J Greenberg, Małgorzata Milewska, Jiameng Sun, Yiming Zhang, Luana Chiquetto Paracatu, Qian Dong, Samuel Ballentine, Weikai Li, Ilona Wandzik, Laura G Schuettpelz, Brian J DeBosch
Tetraspanins are transmembrane signaling and pro-inflammatory proteins. Prior work demonstrates the tetraspanin, CD53/TSPAN25/MOX44 mediates B-cell development, and lymphocyte homing and migration to lymph nodes, and is implicated in various inflammatory diseases including atherosclerosis and microbial infection. However, CD53 is also expressed in highly metabolic tissues, including adipose and liver, yet its function outside of the lymphoid compartment is not defined. Here, we show that CD53 demarcates the nutritional and inflammatory status of hepatocytes...
December 26, 2022: Journal of Biological Chemistry