Suyan Wang, Zhuangzhuang Xu, Yongzhen Liu, Mengmeng Yu, Tao Zhang, Peng Liu, Xiaole Qi, Yuntong Chen, Lingzhai Meng, Ru Guo, Li Zhang, Wenrui Fan, Li Gao, Yulu Duan, Yanping Zhang, Hongyu Cui, Yulong Gao
UNLABELLED: Infectious bursal disease (IBD) is an acute and fatal immunosuppressive disease caused by infectious bursal disease virus (IBDV). As an obligate intracellular parasite, IBDV infection is strictly regulated by host factors. Knowledge on the antiviral activity and possible mechanism of host factors might provide the theoretical basis for the prevention and control of IBD. In this study, RNA-sequencing results indicated that many host factors were induced by IBDV infection, among which the expression levels of OASL (2´,5´-oligadenylate synthetase-like protein) was significantly upregulated...
April 19, 2024: Journal of Virology