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Rheumatology, lupus, sjogrens, scleroderma,rheumatoid arthritis

Cécile L Overman, Marianne B Kool, José A P Da Silva, Rinie Geenen
Fatigue is a common, disabling, and difficult-to-manage problem in rheumatic diseases. Prevalence estimates of fatigue within rheumatic diseases vary considerably. Data on the prevalence of severe fatigue across multiple rheumatic diseases using a similar instrument is missing. Our aim was to provide an overview of the prevalence of severe fatigue across a broad range of rheumatic diseases and to examine its association with clinical and demographic variables. Online questionnaires were filled out by an international sample of 6120 patients (88 % female, mean age 47) encompassing 30 different rheumatic diseases...
February 2016: Clinical Rheumatology
Michael S Farrell, Sean J Wallace, Scott M Clarke, Mushfiqur R Tarafder, William A McLaughlin
Previous studies have described an increased risk of developing an additional connective tissue disease (CTD) when one such ailment is present. We examine here the likelihood that individuals with systemic lupus erythematosus (SLE) screen positive for one or more of the following five autoimmune CTDs: Sjögren's syndrome, scleroderma, rheumatoid arthritis, dermatomyositis/polymyositis, and mixed connective tissue disorder. Five hundred SLE-diagnosed subjects were asked to complete a CTD screening questionnaire (CSQ)...
April 1, 2014: Journal of Primary Care & Community Health
Xinyi Ng, Andrea Hsiu Ling Low, Li-Ching Chew, Yong Yeow Chong, Kok Yong Fong, Nai Lee Lui, Eugene Sim, York Kiat Tan, Jon Yoong, Julian Thumboo
AIMS: To describe the spectrum of diseases seen in an outpatient setting in the Singapore General Hospital, the largest tertiary referral centre in Singapore. METHODS: In this cross-sectional study, medical records of patients scheduled for an appointment at the rheumatology specialist outpatient clinics over a 4-month period (10 August 2010-31 December 2010) were reviewed. Primary diagnoses documented by the attending physician at the latest visit were recorded...
June 2013: International Journal of Rheumatic Diseases
M Atteritano, A David, G Bagnato, C Beninati, A Frisina, C Iaria, G Bagnato, A Cascio
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH), is a potentially fatal hyperinflammatory syndrome characterized fever, hepatosplenomegaly, and cytopenias. HLH can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Among rheumatic disorders, HLH occurs most frequently in systemic juvenile idiopathic arthritis. AIM: To draw attention on this severe syndrome that may often go undiagnosed in patient with rheumatic diseases...
October 2012: European Review for Medical and Pharmacological Sciences
Jasmine R Gaddy, Evan S Vista, Julie M Robertson, Amy B Dedeke, Virginia C Roberts, Wendy S Klein, Jeremy H Levin, Fabio H Mota, Tina M Cooper, Gloria A Grim, Sohail Khan, Judith A James
OBJECTIVE: Rheumatic diseases cause significant morbidity within American Indian populations. Clinical disease presentations, as well as historically associated autoantibodies, are not always useful in making a rapid diagnosis or assessing prognosis. The purpose of our study was to identify autoantibody associations among Oklahoma tribal populations with rheumatic disease. METHODS: Oklahoma tribal members (110 patients with rheumatic disease and 110 controls) were enrolled at tribal-based clinics...
October 2012: Journal of Rheumatology
Teresa Cristina Martins Vicente Robazzi, Luis Fernando Fernandes Adan
Thyroid function abnormalities and thyroid autoantibodies have been frequently described in patients with rheumatologic autoimmune diseases, such as Sjögren's syndrome, rheumatoid arthritis, systemic lupus erythematosus and scleroderma. Limited data are available regarding the prevalence and clinical characteristics of autoimmune thyroiditis in other rheumatologic disorders, such as rheumatic fever and juvenile systemic lupus erythematosus. The authors review the association of endocrine autoimmune and rheumatic autoimmune diseases, assessing various age groups and clinical conditions...
May 2012: Revista Brasileira de Reumatologia
Angela Pakozdi, Svetlana Nihtyanova, Pia Moinzadeh, Voon H Ong, Carol M Black, Christopher P Denton
OBJECTIVE: To determine the prevalence of systemic sclerosis (SSc) overlap syndrome and autoantibody profile in a large single-center cohort. METHODS: SSc diagnoses, subsets, and autoantibody profiles were obtained from clinical records of patients attending the Centre for Rheumatology, Royal Free Hospital, between September 1999 and February 2007. RESULTS: In total, 332 (20%) of 1700 patients with SSc had overlap syndrome. This comprised myositis (42...
November 2011: Journal of Rheumatology
Catharina Eriksson, Heidi Kokkonen, Martin Johansson, Göran Hallmans, Göran Wadell, Solbritt Rantapää-Dahlqvist
INTRODUCTION: Autoantibodies have a central role in systemic lupus erythematosus (SLE). The presence of autoantibodies preceding disease onset by years has been reported both in patients with SLE and in those with rheumatoid arthritis, suggesting a gradual development of these diseases. Therefore, we sought to identify autoantibodies in a northern European population predating the onset of symptoms of SLE and their relationship to presenting symptoms. METHODS: The register of patients fulfilling the American College of Rheumatology criteria for SLE and with a given date of the onset of symptoms was coanalysed with the register of the Medical Biobank, Umeå, Sweden...
2011: Arthritis Research & Therapy
Lucia De Franceschi, Silvia Bosello, Cinzia Scambi, Domenico Biasi, Maria De Santis, Paola Caramaschi, Giusy Peluso, Valentina La Verde, Lisa Maria Bambara, Gianfranco Ferraccioli
Autoimmune-rheumatological diseases are worldwide distributed disorders and represent a complex array of illnesses characterized by autoreactivity (reactivity against self-antigens) of T-B lymphocytes and by the synthesis of autoantibodies crucial for diagnosis (biomarkers). Yet, the effects of the autoimmune chronic inflammation on the infiltrated tissues and organs generally lead to profound tissue and organ damage with loss of function (i.e., lung, kidney, joints, exocrine glands). Although progresses have been made on the knowledge of these disorders, much still remains to be investigated on their pathogenesis and identification of new biomarkers useful in clinical practice...
February 2011: Proteomics. Clinical Applications
Christine Schlenker, Timothy Halterman, Kris V Kowdley
Rheumatologic diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, and scleroderma are immunologically mediated disorders that typically have multisystem involvement. Although clinically significant liver involvement is rare, liver enzyme abnormalities may be observed in up to 43% of patients. The biochemical abnormalities are typically mild and transient and the histologic abnormalities are usually nonprogressive. Such biochemical and histologic findings are typically ascribed to the primary rheumatologic condition and require no specific management...
February 2011: Clinics in Liver Disease
Sasha Bernatsky, Rosalind Ramsey-Goldman, Ann Clarke
Extract: All domains of medical knowledge are rapidly increasing. For example, we now understand more about the fascinating collection of "autoimmune diseases" that share one common feature: an overactive immune system that reacts against normal tissue, causing inflammation and often damage. Simultaneously, there has been an explosion of knowledge in the field of oncology, particularly related to hematological malignancies, including lymphomas. It is in part because of this increased understanding of both autoimmune disorders and malignancy that we have begun to appreciate the links between autoimmune rheumatic disease and cancer risk...
December 2005: Discovery Medicine
J A Goldman
The etiology of connective tissue disease appears to be multifactorial and includes genetic factors, autoimmune responsiveness and environmental elements. This survery in a clinical rheumatology practice has investigated the relationship of environmental occupational organic solvent exposure and the presence of connective tissue disease. Two hundred and seventynine consecutive patients with various connective tissue diseases were classified according to the American College of Rheumatology criteria for systemic lupus erythematosus, systemic sclerosis (scleroderma), and rheumatoid arthritis and clinically as dermatomyositis/polymyositis, mixed connective tissue disease, and Sjogren's syndrome...
August 1996: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Vivien C Abad, Priscilla S A Sarinas, Christian Guilleminault
Arthritis is the leading cause of chronic illness in the United States. Seventy-two percent of the adults aged 55 years and older with arthritis report sleep difficulties. This review discusses sleep disorders associated with rheumatoid arthritis, juvenile rheumatoid arthritis, Sjogren's syndrome, systemic lupus erythematosus, scleroderma, Behcet's disease, seronegative spondyloarthropathies, osteoarthritis, sarcoidosis, and fibromyalgia. We describe the inter-relationship between sleep complaints, disease activity, depression, sleep deprivation, and cytokines...
June 2008: Sleep Medicine Reviews
Federico Mecacci, Annalisa Pieralli, Barbara Bianchi, Michael J Paidas
Autoimmune diseases are a group of heterogeneous disorders equally characterized by the same pathogenetic mechanism: an immunological reaction against self antigens promoted by antibodies, immuno-complex formation, and self-reactive T lymphocytes. Autoimmune diseases may be separated into organ-restricted diseases and systemic ones. The damage of single organs produced by antibodies focused against specific cellular antigens characterizes the first group of diseases, whereas the latter are produced by a systemic inflammatory process initiated by inappropriate and excess immune activation that leads to immuno-complex formation and deposition onto sensitive tissues...
August 2007: Seminars in Perinatology
Thomas N Hyphantis, Niki Tsifetaki, Vassiliki Siafaka, Paraskevi V Voulgari, Christina Pappa, Marina Bai, Kalliopi Palieraki, Aliki Venetsanopoulou, Venetsanos Mavreas, Alexandros A Drosos
OBJECTIVE: To access health-related quality of life (HRQOL) in systemic sclerosis (SSc) patients using the World Health Organization Quality of Life Instrument, Short-Form (WHOQOL-BREF), and to identify the association between clinical, psychopathological, and personality parameters and SSc patients' HRQOL. METHODS: Fifty-six patients with SSc were compared with 72 patients with rheumatoid arthritis (RA), 43 with systemic lupus erythematosus (SLE), 34 with Sjögren syndrome (SS), and 74 healthy controls...
October 2007: Seminars in Arthritis and Rheumatism
Ivan Dobrić
The Intruduction includes those eflorescences that might be useful for diagnostics in rheumatology. Further in the text we have described four groups of rheumatic disorders. The first group: rheumatic diseases (lupus erythematosus, dermatomyositis, systemic scleroderma, the mixed connective tissue disease, allergic vasculitis, polyarteritis) which are the most common from the dermatological point of view. The second group: rheumatic diseases (Wegener's granulomatosis, rheumatoid arthritis, Sjögren, Reiter and Behçet syndrome and Kawasaki's disease) which are rarely of interest to our dermatologists...
2005: Reumatizam
Nuran Turkcapar, Umit Olmez, Didem Ozer, Nursen Duzgun, Murat Duman
We report an unusual case of overlap syndrome that had the coexistence of five autoimmune diseases. A 45-year-old woman initially developed seropositive erosive rheumatoid arthritis (RA) 11 years ago. She then developed progressive systemic sclerosis (PSS) (including pulmonary hypertension, esophageal dysfunction, cardiac involvement and sclerodactilitis), systemic lupus erythematosus (SLE) (including photosensitivity, nephritis, leukopenia, lymphopenia, thrombocytopenia and Coombs positive hemolytic anemia and positive anti-dsDNA), and secondary Sjögren's syndrome (SSS) in the last 7 years before she was admitted to our clinic...
July 2006: Rheumatology International
Karl C Golnik
Rheumatologic and inflammatory systemic diseases often cause similar neurologic and neuro-ophthalmologic manifestations. A wide variety of conditions can be included in these categories. This article summarizes the most common of these conditions, including sarcoidosis, idiopathic orbital inflammation, inflammatory bowel disease, Wegener's granulomatosis, polyarteritis nodosa, Churg-Strauss syndrome, Behcet's disease, systemic lupus erythematosis, scleroderma, Sjogren's syndrome, and rheumatoid arthritis.
September 2004: Ophthalmology Clinics of North America
Marianne Frieri
There are several rheumatologic and autoimmune disorders that can masquerade as allergic disease. Identification of these conditions in an office setting can be a challenge for the practicing allergist-immunologist. These conditions include rheumatoid and juvenile arthritis, Sjogren's syndrome, systemic lupus erythematosus, Behcet's and antiphospholipid syndromes, systemic sclerosis, vasculitis, sarcoidosis, chronic fatigue syndrome, and fibromyalgia. The article will address these topics and include clinical uses of immunologic tests for diagnosis...
November 2003: Allergy and Asthma Proceedings:
Hye-Soon Lee, Kwang-Taek Oh, Tae-Hwan Kim, Sungsoo Jung, Dae-Hyun Yoo, Sang-Cheol Bae
The aim of our study was to develop a Korean rheumatic diseases-screening questionnaire. The questionnaire was constructed based on American College of Rheumatology criteria for rheumatic diseases and a connective tissue diseases screening questionnaire. Two groups of patients were selected and completed the questionnaire: (i) those with osteoarthritis (n=46), rheumatoid arthritis (n=52), systemic lupus erythematosus (n=50), scleroderma (n=8), polymyositis or dermatomyositis (n=7), Sjogren's disease (n=4), and mixed connective-tissue disease (n=9) as case subjects; and (ii) those with fibromyalgia (n=8) and general disease without evidence of any rheumatic disease (n=72) as controls...
April 2003: Journal of Korean Medical Science
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