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Focal therapy for prostate cancer

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https://www.readbyqxmd.com/read/28318726/low-risk-prostate-cancer-identification-management-and-outcomes
#1
REVIEW
Marco Moschini, Peter R Carroll, Scott E Eggener, Jonathan I Epstein, Markus Graefen, Rodolfo Montironi, Christopher Parker
CONTEXT: The incidence of low-risk prostate cancer (PCa) has increased as a consequence of prostate-specific antigen testing. OBJECTIVE: In this collaborative review article, we examine recent literature regarding low-risk PCa and the available prognostic and therapeutic options. EVIDENCE ACQUISITION: We performed a literature review of the Medline, Embase, and Web of Science databases. The search strategy included the terms: prostate cancer, low risk, active surveillance, focal therapy, radical prostatectomy, watchful waiting, biomarker, magnetic resonance imaging, alone or in combination...
March 15, 2017: European Urology
https://www.readbyqxmd.com/read/28274241/salvage-prostate-re-irradiation-using-high-dose-rate-brachytherapy-or-focal-stereotactic-body-radiotherapy-for-local-recurrence-after-definitive-radiation-therapy
#2
Aurélie Mbeutcha, Laurent Chauveinc, Pierre-Yves Bondiau, Marie-Eve Chand, Matthieu Durand, Daniel Chevallier, Jean Amiel, Daniel Lam Cham Kee, Jean-Michel Hannoun-Lévi
BACKGROUND: Optimal management of locally recurrent prostate cancer after definitive radiation therapy is still challenging. With the development of highly accurate radiotherapy devices, prostate salvage re-irradiation might generate lower toxicity rates than classical salvage therapies. We retrospectively evaluated the toxicity and the feasibility of a prostate re-irradiation after definitive radiation therapy failure. Two modalities were investigated: high-dose-rate brachytherapy (HDRB) on whole prostate gland and focal stereotactic radiotherapy (SBRT) using CyberKnife® linac...
March 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28258616/focal-salvage-hifu-in-radiorecurrent-prostate-cancer
#3
A Kanthabalan, M Peters, M Van Vulpen, N McCartan, R G Hindley, A Emara, M C Moore, M Arya, M Emberton, H U Ahmed
OBJECTIVE: To assess short to medium term cancer control rates and side effects of focal salvage High Intensity Focused Ultrasound (HIFU). MATERIALS AND METHODS: A retrospective registry analysis identified 150 men who underwent focal salvage HIFU (Sonablate 500) (November 2006-August 2015). Metastatic disease was excluded using the nodal assessment on the pelvic MRI, a radioisotope bone scan and PET imaging (choline-FDG-PET or Choline PET-CT). In our current clinical practice, metastatic disease must be ruled out by both Choline PET and bone scan...
March 4, 2017: BJU International
https://www.readbyqxmd.com/read/28247740/-focal-laser-thermocoagulation-for-localized-prostate-cancer
#4
P V Glybochko, A Z Vinarov, E V Shpot, N I Sorokin, A M Dymov, D V Chinenov, D V Enikeev, E A Shmeleva, A V Koshkarev, I S Lumpov
Focal therapy involving destruction of prostate specific region containing a clinically meaningful tumor is a new treatment for prostate cancer. Despite the absence of long-term results of applying this method of treatment, there are prerequisites that allow to consider focal therapy as a method with a lower risk of side effects typical of conventional treatment. Focal laser thermocoagulation is a developing technique with a number of advantages, the most important of which is the ability to perform the treatment under the real-time magnetic resonance imaging control...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28243479/robotic-assisted-laparoscopic-prostatectomy-after-high-intensity-focused-ultrasound-failure
#5
Leon Telis, Seyed Behzad Jazayeri, David B Samadi
Background. Prostate cancer is the most common cancer diagnosed in men. As new focal therapies become more popular in treatment of prostate cancer, failure cases requiring salvage therapy with either surgical or other techniques are being reported. Objective. To report the options in treatment of prostate cancer after recurrence or failure of the primary treatment modality. Methods. We report a salvage robotic assisted laparoscopic radical prostatectomy (RALP) for prostate cancer recurrence following high intensity focused ultrasound treatment (HIFU) in the United States...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28238758/pathological-findings-in-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-relation-to-prostate-cancer-focal-therapy
#6
REVIEW
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsy can detect more clinically significant prostate cancers and aid in accurate detection of higher-grade disease...
February 24, 2017: Urology
https://www.readbyqxmd.com/read/28163032/impact-of-gleason-subtype-on-prostate-cancer-detection-using-multiparametric-mri-correlation-with-final-histopathology
#7
Matthew Truong, Gary Hollenberg, Eric Weinberg, Edward M Messing, Hiroshi Miyamoto, Thomas P Frye
PURPOSE: Our purpose was to determine whether Gleason pattern 4 architecture impacts tumor visibility on multiparametric (mpMRI) and correlate with final histopathology. MATERIALS AND METHODS: A total of 83 tumor foci were identified within 22 radical prostatectomy specimens from patients with a prior negative biopsy who underwent MR/US fusion biopsy followed by radical prostatectomy from January 2015-July 2016. A genitourinary pathologist re-reviewed tumor foci for Gleason architectural subtype...
February 2, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28111893/robot-assisted-partial-prostatectomy-for-anterior-prostate-cancer-a-step-by-step-guide
#8
Arnauld Villers, Vincent Flamand, Rodríguez-Carlin Arquímedes, Philippe Puech, Georges-Pascal Haber, Mihir M Desai, Sebastien Crouzet, Adil Ouzzane, Inderbir S Gill
OBJECTIVE: To describe a step-by-step guide to robot-assisted anterior partial prostatectomy (RA-APP) for isolated magnetic resonance imaging (MRI)-detected anterior prostate cancer (APC). PATIENTS AND METHODS: After Institutional Review Board approval, over an 8-year period (2008-2015), 17 consenting patients were enrolled in a prospective, single-arm, single-centre, Idea, Development, Evaluation, Assessment and Long-term evaluation of innovative surgery (IDEAL) phase 2a study...
January 23, 2017: BJU International
https://www.readbyqxmd.com/read/28046739/su-f-j-225-histology-study-of-mr-guided-pulsed-focused-ultrasound-on-treatment-of-prostate-cancer-in-vivo
#9
L Chen, D Cvetkovic, X Chen, B Wang, R Gupta, C Ma
PURPOSE: Our previous study demonstrated significant tumor growth delay in the mice treated with pulsed high intensity focused ultrasound (pHIFU). The purpose of this study is to understand the cell killing mechanisms of pHIFU. METHODS: Prostate cancer cells (LNCaP), were grown orthotopically in 17 nude mice. Tumor-bearing mice were treated using pHIFU with an acoustic power of 25W, pulse width 100msec and 300 pulses in one sonication under MR guidance. Mutiple sonications were used to cover the whole tumor volume...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042330/comparison-of-68-ga-hbed-cc-psma-pet-ct-and-multiparametric-mri-for-gross-tumour-volume-detection-in-patients-with-primary-prostate-cancer-based-on-slice-by-slice-comparison-with-histopathology
#10
Constantinos Zamboglou, Vanessa Drendel, Cordula A Jilg, Hans C Rischke, Teresa I Beck, Wolfgang Schultze-Seemann, Tobias Krauss, Michael Mix, Florian Schiller, Ulrich Wetterauer, Martin Werner, Mathias Langer, Michael Bock, Philipp T Meyer, Anca L Grosu
PURPOSE: The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared (68)Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation with histopathological reference material. METHODOLOGY: Seven patients with histopathologically proven primary PCa underwent (68)Ga-HBED-CC-PSMA PET/CT and MRI followed by radical prostatectomy...
2017: Theranostics
https://www.readbyqxmd.com/read/27999928/erratum-to-focal-salvage-therapy-for-local-prostate-cancer-recurrences-after-primary-radiotherapy-a-comprehensive-review
#11
D A Smit Duijzentkunst, M Peters, J R N van der Voort van Zyp, M A Moerland, M van Vulpen
No abstract text is available yet for this article.
December 20, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27997415/high-intensity-focused-ultrasound-for-focal-therapy-reality-or-pitfall
#12
Ariel A Schulman, Kae Jack Tay, Cary N Robertson, Thomas J Polascik
PURPOSE OF REVIEW: Progress in imaging, fusion software, and ablative modalities has fostered growth of the latest image-guided generation of high-intensity focused ultrasound (HIFU) for focal treatment of prostate cancer. Although early reports are encouraging, important questions remain regarding candidate selection, treatment, and outcomes. We review contemporary considerations for the use of HIFU for focal treatment of primary and radio-recurrent prostate cancer. RECENT FINDINGS: HIFU has been used to treat prostate cancer for over two decades...
March 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/27986210/emerging-technologies-and-techniques-in-radiation-therapy
#13
REVIEW
William J Magnuson, Amandeep Mahal, James B Yu
The past decade has brought an improved ability to precisely target and deliver radiation as well as other focal prostate-directed therapy. Stereotactic body radiotherapy (SBRT), proton beam radiation, high-dose-rate (HDR) brachytherapy, as well as nonradiotherapy treatments such as cryoablation and high-intensity focused ultrasound are several therapeutic modalities that have been investigated for the treatment of prostate cancer in an attempt to reduce toxicity while improving cancer control. However, high-risk prostate cancer requires a comprehensive treatment of the prostate as well as areas at risk for cancer spread...
January 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/27955940/magnetic-resonance-imaging-transrectal-ultrasound-fusion-focal-cryotherapy-of-the-prostate-a-prospective-development-study
#14
Massimo Valerio, Taimur Tariq Shah, Paras Shah, Neil Mccartan, Mark Emberton, Manit Arya, Hashim Uddin Ahmed
OBJECTIVES: The use of software-based magnetic resonance-transrectal ultrasound fusion to deliver focal therapy may increase the precision of treatment. This is a prospective development study assessing the feasibility of Magnetic resonance imaging-transrectal ultrasound (MRI-TRUS) fusion focal cryotherapy. METHODS AND MATERIALS: Consecutive patients undergoing focal cryotherapy were included in an academic registry (December 2013-June 2014). MRI-TRUS fusion focal cryotherapy was offered to men with visible clinically significant prostate cancer (Galil SeedNet system)...
December 7, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27882770/focal-therapy-as-primary-treatment-for-localized-prostate-cancer-definition-needs-and-future
#15
Adil Ouzzane, Nacim Betrouni, Massimo Valerio, Ardeshir Rastinehad, Pierre Colin, Guillaume Ploussard
Focal therapy (FT) may offer a promising treatment option in the field of low to intermediate risk localized prostate cancer. The aim of this concept is to combine minimal morbidity with cancer control as well as maintain the possibility of retreatment. Recent advances in MRI and targeted biopsy has improved the diagnostic pathway of prostate cancer and increased the interest in FT. However, before implementation of FT in routine clinical practice, several challenges are still to overcome including patient selection, treatment planning, post-therapy monitoring and definition of oncologic outcome surrogates...
November 24, 2016: Future Oncology
https://www.readbyqxmd.com/read/27846402/focal-therapy-in-prostate-cancer-a-review-of-seven-common-controversies
#16
REVIEW
Edward J Bass, Hashim U Ahmed
Radical treatments such as prostatectomy and radiotherapy have demonstrated success in terms of biochemical and disease-specific survival for localised prostate cancer. However, whilst the end goal of any cancer treatment is to control or cure disease it must also do so by minimising any side effects that may be experienced by the patient. Focal therapy as a concept aims to redress this established therapeutic ratio by treating areas of the prostate affected by significant disease as opposed to treating the entire gland...
December 2016: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/27844131/-mri-trus-fusion-guided-prostate-biopsy-value-in-the-context-of-focal-therapy
#17
T Franz, J von Hardenberg, A Blana, H Cash, D Baumunk, G Salomon, B Hadaschik, T Henkel, J Herrmann, F Kahmann, K-U Köhrmann, J Köllermann, S Kruck, U-B Liehr, S Machtens, I Peters, J P Radtke, A Roosen, H-P Schlemmer, L Sentker, J J Wendler, U Witzsch, J-U Stolzenburg, M Schostak, R Ganzer
BACKGROUND: Several systems for MRI/TRUS fusion-guided biopsy of the prostate are commercially available. Many studies have shown superiority of fusion systems for tumor detection and diagnostic quality compared to random biopsy. The benefit of fusion systems in focal therapy of prostate cancer (PC) is less clear. OBJECTIVES: Critical considerations of fusion systems for planning and monitoring of focal therapy of PC were investigated. MATERIALS AND METHODS: A systematic literature review of available fusion systems for the period 2013-5/2016 was performed...
February 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27825432/psma-pet-and-radionuclide-therapy-in-prostate-cancer
#18
REVIEW
Kirsten Bouchelouche, Baris Turkbey, Peter L Choyke
Prostate cancer (PCa) is the most common malignancy in men and a major cause of cancer death. Accurate imaging plays an important role in diagnosis, staging, restaging, detection of biochemical recurrence, and for therapy of patients with PCa. Because no effective treatment is available for advanced PCa, there is an urgent need to develop new and more effective therapeutic strategies. To optimize treatment outcome, especially in high-risk patients with PCa, therapy for PCa is moving rapidly toward personalization...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27814981/hemi-gland-focal-low-dose-rate-prostate-brachytherapy-an-analysis-of-dosimetric-outcomes
#19
Robert Laing, Adrian Franklin, Jennifer Uribe, Alex Horton, Santiago Uribe-Lewis, Stephen Langley
BACKGROUND AND PURPOSE: Advances in magnetic resonance imaging (MRI) and prostate sampling enable early identification of men with low to intermediate risk prostate cancer who are candidates for focal therapies that minimise side effects. We report dosimetry data from a pilot study evaluating the effectiveness of hemi-gland low dose rate (HG-LDR) brachytherapy as a focal therapy approach to control unilateral localised disease. MATERIAL AND METHODS: Twenty-two men underwent HG-LDR brachytherapy...
November 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27809594/outcomes-and-toxicities-in-patients-treated-with-definitive-focal-therapy-for-primary-prostate-cancer-systematic-review
#20
REVIEW
Atallah Baydoun, Bryan Traughber, Nathan Morris, Michella Abi Zeid Daou, Michael McGraw, Tarun K Podder, Raymond F Muzic, Simon S Lo, Lee E Ponsky, Mitchell Machtay, Rodney Ellis
AIM: This systematic review summarizes the clinical data on focal therapy (FT) when used alone as definitive therapy for primary prostate cancer (PCa). METHODS: The protocol is detailed in the online PROSPERO database, registration No. CRD42014014765. Articles evaluating any form of FT alone as a definitive treatment for PCa in adult male patients were included. RESULTS: Of 10,419 identified articles, 10,401 were excluded, and thus leaving 18 for analysis...
March 2017: Future Oncology
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