Read by QxMD icon Read


Hun-Jae Jang, Seonggu Yeo, Jack J Yoh
BACKGROUND AND AIMS: For conventional needless injection, there still remain many unresolved issues such as the potential for cross-contamination, poor reliability of targeted delivery dose, and significantly painstaking procedures. As an alternative, the use of microjets generated with Er:YAG laser for delivering small doses with controlled penetration depths has been reported. In this study, a new system with two stages is evaluated for effective transdermal drug delivery. First, the skin is pre-ablated to eliminate the hard outer layer and second, laser-driven microjet penetrates the relatively weaker and freshly exposed epidermis...
October 25, 2016: Lasers in Surgery and Medicine
H Jodaa Holm, S Skugor, A K Bjelland, S Radunovic, S Wadsworth, E O Koppang, Ø Evensen
Atlantic salmon skin tissues with and without scales were taken from two preferred sites of salmon louse (Lepeophtheirus salmonis) attachment, behind the dorsal fin (scaled) and from the top of the head (scaleless), respectively. Tissues were profiled by qPCR of 32 genes to study responses to copepodids, 4 days post infection (dpi), and during the moult of copepodids to the chalimus stage, at 8 dpi. Basal/constitutive differences were found for many immune-related genes between the two skin sites; e.g., mannose binding protein C was over 100 fold higher expressed in the scaled skin from the back in comparison to the skin without scales from the head...
October 21, 2016: Developmental and Comparative Immunology
ChunSik Choe, Jürgen Lademann, Maxim E Darvin
Confocal Raman microscopy has been used to measure depth-dependent profiles of human SC in vivo in the high wavenumber (HWN) region. In order to keep the linearity of HWN region boundaries and to not remove an informative signal from Raman spectra, a new baseline subtraction procedure has been introduced. After baseline subtraction, the HWN spectrum was deconvoluted using 10 Gaussian functions with individual chemical meanings. The results show that the hydrogen bound water molecule types contributed differently to the water diffusion process in the SC...
October 24, 2016: Analyst
M A Beydoun, H A Beydoun, N Mode, G A Dore, J A Canas, S M Eid, A B Zonderman
BACKGROUND: Studies uncovering factors beyond socio-economic status (SES) that would explain racial and ethnic disparities in mortality are scarce. METHODS: Using prospective cohort data from the Third National Health and Nutrition Examination Survey (NHANES III), we examined all-cause and cause-specific mortality disparities by race, mediation through key factors and moderation by age (20-49 vs. 50+), sex and poverty status. Cox proportional hazards, discrete-time hazards and competing risk regression models were conducted (N = 16,573 participants, n = 4207 deaths, Median time = 170 months (1-217 months))...
October 22, 2016: BMC Public Health
Jingyu Deng, Hiroharu Yamashita, Yasuyuki Seto, Han Liang
BACKGROUND: This study aims to elucidate whether increasing the number of examined lymph nodes (NELN) is mandatory for the accurate prognosis of node-negative gastric cancer (GC) patients after curative gastrectomy in Eastern countries (China and Japan). METHODS: The clinicopathological data of 2455 GC patients (including 1137 node-negative cases) were included to demonstrate whether a minimum NELN is inevitable for guaranteeing the accurate prognosis of node-negative GC patients after curative gastrectomy...
October 21, 2016: Annals of Surgical Oncology
Satomi Igawa, Mari Kishibe, Masako Minami-Hori, Masaru Honma, Hisashi Tsujimura, Junko Ishikawa, Tsutomu Fujimura, Masamoto Murakami, Akemi Ishida-Yamamoto
Atopic dermatitis (AD) is a common inflammatory skin disorder. Chronic AD lesions present hyperkeratosis, indicating a disturbed desquamation process. Kallikrein-related peptidase (KLK) 7 is a serine protease involved in the proteolysis of extracellular corneodesmosome (CD) components, including desmocollin1 and corneodesmosin (Cdsn), which leads to desquamation. KLK7 is secreted by lamellar granules, and upregulated in AD lesional skin. However, despite increased KLK7 protein levels, immunostaining and electron microscopy indicated numerous CDs remaining in the uppermost layer of the stratum corneum (SC) from AD lesions...
October 18, 2016: Journal of Investigative Dermatology
Shufang Yang, Ran Wang, Guang Wan, Zhimin Wu, Shujuan Guo, Xingxing Dai, Xinyuan Shi, Yanjiang Qiao
Menthol is a widely used penetration enhancer in clinical medicine due to its high efficiency and relative safety. However, details of the penetration enhancement mechanism of menthol on molecular level is rarely involved in the discussion. In this work, the penetration enhancement (PE) mechanism of menthol is explored by a multiscale method containing molecular dynamics simulations, in vitro penetration experiments and transmission electron microscopy. Osthole is chosen to be the tested drug due to its common-using in external preparations and its representative-accompanying with menthol as a PE in the preparations...
October 21, 2016: Journal of Chemical Information and Modeling
Émilie Faway, Ludivine Cambier, Bernard Mignon, Yves Poumay, Catherine Lambert de Rouvroit
Dermatophytosis is a superficial fungal infection of keratinized structures that exhibits an increasing prevalence in humans and is thus requesting novel prophylactic strategies and therapies. However, precise mechanisms used by dermatophytes to adhere at the surface of the human epidermis and invade its stratum corneum are still incompletely identified, as well as the responses provided by the underlying living keratinocytes during the infection. We hereby report development of an in vitro model of human dermatophytosis through infection of reconstructed human epidermis (RHE) by arthroconidia of the anthropophilic Trichophyton rubrum species or of the zoophilic Microsporum canis and Arthroderma benhamiae species...
October 19, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
S Saeidpour, S B Lohan, M Anske, M Unbehauen, E Fleige, R Haag, M C Meinke, R Bittl, C Teutloff
The skin and especially the stratum corneum (SC) act as a barrier and protect epidermal cells and thus the whole body against xenobiotica of the external environment. Topical skin treatment requires an efficient drug delivery system (DDS). Polymer-based nanocarriers represent novel transport vehicles for dermal application of drugs. In this study dendritic core-multishell (CMS) nanoparticles were investigated as promising candidates. CMS were loaded with a drug (analogue) and were applied to penetration studies of skin...
October 15, 2016: European Journal of Pharmaceutics and Biopharmaceutics
Lawrence Szewciw, Francois Barthelat
Teleost fish skin is a multifunctional natural material with high penetration resistance owing to specialized puncture mechanisms of both the individual scale and the intact scaled integument. In this paper, we explore the possible additional role of the skin in fish undulatory locomotion by examining the structural and mechanical properties of the dermal stratum (s.) compactum layer of striped bass (Morone saxatilis) skin. The structure, mechanical response and function of s. compactum was investigated by combining several methods: optical microscopy and histology, tensile tests on descaled skin specimens in different anatomical locations and orientations, puncture tests, and flexural tests on whole fish with disruption of the s...
September 28, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Minjuan He, Amao Tang, Xuedi Ge, Jie Zheng
OBJECTIVE: The aim of this study was to determine whether skin barrier factors were associated with the common complication of pressure ulcers (PrUs) in intensive care unit (ICU) patients. It is unclear whether skin barrier factors influence the development of PrUs. PATIENT POPULATION: The sample was composed of 102 ICU patients (54 men, 48 women). The patients ranged in age from 23 to 88 years, with a mean age of 55.7 (SD, 19.1) years. METHODS: Demographic variables and the score for the Acute Physiology and Chronic Health Evaluation IV were recorded on admission...
November 2016: Advances in Skin & Wound Care
Satoshi Hoshide, Yuichiro Yano, Hajime Haimoto, Kayo Yamagiwa, Kiyoshi Uchiba, Shoichiro Nagasaka, Yoshio Matsui, Akira Nakamura, Motoki Fukutomi, Kazuo Eguchi, Joji Ishikawa, Kazuomi Kario
OBJECTIVE: The SPRINT (Systolic Blood Pressure Intervention Trial) recently demonstrated that strict blood pressure (BP) control resulted in a lower cardiovascular disease (CVD) risk compared to standard BP control, however, this association was not observed regarding the incidence of stroke. Previous studies revealed that the contribution of BP as a risk factor was higher for stroke incidence than for any other CVD, especially in Asian populations. It is thus not clear whether the results of the SPRINT can be generalized to all Asian populations...
September 2016: Journal of Hypertension
Fengcai Zhu, Henri Deckx, Raphaele Roten, Bart Michiels, Michal Sarnecki
AIM: Compare efficacy, immunogenicity and safety of Hepavax-Gene TF (thimerosal free) vaccine with comparator in Chinese neonates. METHODS: Double-blind, randomized, parallel-group, stratified study was conducted at multiple sites in China in healthy neonates, consisting of three doses of Hepavax-Gene TF or Engerix-B vaccines administered at birth, one and six months of age, with a six month follow-up after vaccination. Based on hepatitis B virus (HBV) infection status of mothers, infants were assigned to one of two study strata for mothers positive for HBV infection (Stratum 1), with or without active replicating virus (Substrata 1a, 1b) and for HBV negative mothers (Stratum 2)...
October 6, 2016: Pediatric Infectious Disease Journal
Samuel Dery, Frances da-Costa Vroom, Anthony Godi, Seth Afagbedzi, Duah Dwomoh
BACKGROUND: Studies have shown that ICT adoption contributes to productivity and economic growth. It is therefore important that health workers have knowledge in ICT to ensure adoption and uptake of ICT tools to enable efficient health delivery. OBJECTIVE: To determine the knowledge and use of ICT among students of the College of Health Sciences at the University of Ghana. METHODS: This was a cross-sectional study conducted among students in all the five Schools of the College of Health Sciences at the University of Ghana...
September 2016: Ghana Medical Journal
Diane J Davies, Jon R Heylings, Heather Gayes, Timothy J McCarthy, M Catherine Mack
A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum corneum, mimicking impaired barrier function observed in humans with damaged skin. The skin penetration and distribution of chemicals with differing physicochemical properties, namely; Benzoic acid, 3-Aminophenol, Caffeine and Sucrose has been assessed in this model...
October 14, 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Olivier Mir, Thomas Brodowicz, Antoine Italiano, Jennifer Wallet, Jean-Yves Blay, François Bertucci, Christine Chevreau, Sophie Piperno-Neumann, Emmanuelle Bompas, Sébastien Salas, Christophe Perrin, Corinne Delcambre, Bernadette Liegl-Atzwanger, Maud Toulmonde, Sarah Dumont, Isabelle Ray-Coquard, Stéphanie Clisant, Sophie Taieb, Cécile Guillemet, Maria Rios, Olivier Collard, Laurence Bozec, Didier Cupissol, Esma Saada-Bouzid, Christine Lemaignan, Wolfgang Eisterer, Nicolas Isambert, Loïc Chaigneau, Axel Le Cesne, Nicolas Penel
BACKGROUND: Regorafenib is a multikinase inhibitor with proven activity in refractory gastrointestinal stromal tumours and chemotherapy-refractory advanced colorectal cancers. We assessed this agent's efficacy and safety in patients with metastatic soft tissue sarcomas previously treated with anthracycline. METHODS: In this randomised, double-blind, phase 2 trial undertaken in France and Austria, we enrolled patients aged 18 years and older with advanced soft tissue sarcomas who had received previous doxorubicin or other anthracycline treatment...
October 14, 2016: Lancet Oncology
Yoon Seob Kim, Kwan Ho Jeong, Jung Eun Kim, Young Jun Woo, Beom Joon Kim, Hoon Kang
BACKGROUND: Microneedle is a method that creates transdermal microchannels across the stratum corneum barrier layer of skin. No previous study showed a therapeutic effect of microneedle itself on hair growth by wounding. OBJECTIVE: The aim of this study is to investigate the effect of repeated microwound formed by microneedle on hair growth and hair growth-related genes in a murine model. METHODS: A disk microneedle roller was applied to each group of mice five times a week for three weeks...
October 2016: Annals of Dermatology
Huixin Luo, Huimin Li, Xiaoyuan Yang, Jing Li, Xinge Zhang, Zhongming Wu
To overcome the chemical penetration enhancer-associated toxicities, without sacrificing delivery efficiency, a functional ε-polylysine (EPL-g-Cetyl) as polymeric permeation enhancers was synthesized by the hydrophobic modification of amino groups of ε-polylysine. The obtained EPL-g-Cetyl nanoparticles had about 200 nm in size with narrower distribution, high positive charge, and good stability. A high loading capacity (up to 17%) of the formulation provided a sustained and controlled release pattern of insulin from the nanoparticles...
October 13, 2016: Journal of Pharmaceutical Sciences
Taeko Mizutani, Hijiri Sumida, Yuki Sagawa, Yuri Okano, Hitoshi Masaki
BACKGROUND: Carbonylated proteins (CPs) are generated by the reaction of basic amino acid residues in proteins with aldehyde compounds produced during lipid peroxidation. CPs in the stratum corneum (SC) impact skin conditions such as skin moisture functions including water content and transepidermal water loss (TEWL). In addition, CPs can be frequently seen in the SC from sun-exposed sites compared with sun-protected sites. OBJECTIVE: The aim of this study was to reveal whether CPs could be a generation source of reactive oxygen species (ROS) in the SC following exposure to ultraviolet (UV) radiation and to identify the type of ROS and its generation mechanism...
September 28, 2016: Journal of Dermatological Science
Atsushi Miyajima, Takashi Hirota, Mari Tashiro, Wataru Noguchi, Yayoi Kawano, Takehisa Hanawa, Akira Kigure, Taichi Anata, Yosuke Yamamoto, Nae Yuasa, Machi Koshino, Yumi Shiraishi, Kaoru Yuzawa, Keita Akagi, Takashi Yoshimasu, Kuniko Makigami, Masayo Komoda
As a novel administration method of ivermectin (IVM) for scabies treatment, we proposed a "whole-body bathing method (WBBM)". In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole-body bathing examination (second trial) were conducted in healthy volunteers...
October 15, 2016: Journal of Dermatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"