Charysse Vandendriessche, Arnout Bruggeman, Joyce Foroozandeh, Lien Van Hoecke, Pieter Dujardin, Junhua Xie, Griet Van Imschoot, Elien Van Wonterghem, Jonas Castelein, Cristiano Lucci, Lies De Groef, Roosmarijn E Vandenbroucke
Parkinson's disease (PD) patients harbour seeding competent α-syn in their cerebrospinal fluid (CSF), which is mainly produced by the choroid plexus (ChP). Nonetheless, little is known about the role of the CSF and the ChP in PD pathogenesis. To address this question, we used an intracerebroventricular (icv) injection mouse model to assess CSF α-syn spreading and its short- and long-term consequences on the brain. Hereby, we made use of seeding competent, recombinant α-syn pre-formed fibrils (PFF) that are known to induce aggregation and subsequent spreading of endogenous α-syn in stereotactic tissue injection models...
February 21, 2024: ENeuro