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https://www.readbyqxmd.com/read/29328541/gm-csf-ameliorates-micro-vascular-barrier-integrity-via-pericytes-derived-ang-1-in-wound-healing
#1
Min Yan, Yange Hu, Min Yao, Shisan Bao, Yong Fang
BACKGROUND: Skin wound healing involves complex coordinated interactions of cells, tissues and mediators. Maintaining microvascular barrier integrity is one of the key events for endothelial homeostasis during wound healing. Vasodilation is observed after vasoconstriction, which causes blood vessels to become porous, facilitates leukocyte infiltration and aids angiogenesis at the wound-area, post-injury. Eventually, vessel integrity has to be re-established for vascular maturation. Numerous studies have found that granulocyte macrophage colony-stimulating factor (GM-CSF) accelerates wound healing by inducing recruitment of repair cells into the injury area and releases of cytokines...
January 12, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29325471/intracranial-subarachnoid-hemorrhage-following-cervical-laminoplasty-a-report-of-two-cases
#2
Yuichi Kondo, Kazunari Fushimi, Makoto Takasawa, Shigeo Kanamori, Takaki Miyagawa, Kenji Kawashima, Kazutoshi Yokoyama, Haruhiko Akiyama
Intracranial hemorrhage is a rare complication of spinal surgery. Case 1 was a 58-year-old man who underwent cervical laminoplasty. No apparent iatrogenic dural rupture or cerebrospinal fluid leakage was observed. An hour after the surgery, the patient had convulsions and became restless thereafter. CT revealed an intracranial SAH. The patient recovered normal consciousness the next morning. Case 2 was a 68-year-old woman who underwent cervical laminoplasty without postoperative CSF leakage. Six days after the surgery, the patient continued to complain of nausea and headache...
January 12, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29322972/a-randomized-controlled-trial-to-determine-the-role-of-intraoperative-lumbar-cerebrospinal-fluid-drainage-in-patients-undergoing-endoscopic-transsphenoidal-surgery-for-pituitary-adenomas
#3
Gandham E Jonathan, Sauradeep Sarkar, Georgene Singh, Sunithi Mani, Regi Thomas, Ari George Chacko
BACKGROUND: Intraoperative cerebrospinal fluid (CSF) leaks are a frequent cause of morbidity in patients undergoing transsphenoidal surgery. This prospective study was performed to examine the impact of intraoperative lumbar subarachnoid drainage (LSAD) on the incidence of this complication and on the extent of resection in patients undergoing endoscopic transsphenoidal surgery for pituitary adenomas. MATERIALS AND METHODS: This prospective study was conducted in a single large academic medical center...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29314715/outcomes-of-endoscopic-and-microscopic-transsphenoidal-surgery-on-non-functioning-pituitary-adenomas-a-systematic-review-and-meta-analysis
#4
Shi-Yuan Yu, Qiu Du, Si-Yuan Yao, Ke-Nan Zhang, Jian Wang, Zhe Zhu, Xiao-Bing Jiang
Both microscopic and endoscopic transsphenoidal surgery are effective approaches for nonfunctioning pituitary adenomas. The issue on the comparison of their efficacy and safety remains inconsistent. A thorough search of the literatures (PubMed, EMBASE, MEDLINE) were performed up to March 2017. Studies reporting outcomes of microscopic or endoscopic transsphenoidal surgery on nonfunctioning pituitary adenomas were included. A meta-analysis was performed focusing on the early stage and long term outcomes. The final search yielded 19 eligible studies enrolling 3847 patients, 389 of them underwent microscopic approach and 3458 of them with endoscopic approach...
January 4, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29305685/frontoethmoidal-encephalocele-clinical-presentation-diagnosis-treatment-and-complications-in-400-cases
#5
Muhammad Arifin, Wihasto Suryaningtyas, Abdul Hafid Bajamal
PURPOSE: The purpose of this study is to review a large series of frontoethmoidal encephalocele (FEE) regarding their clinical presentation, the progressiveness of the mass volume, the skin stigmata as well as its surgical approach and post-surgical complications. METHOD: Records of all FEE patients treated in Soetomo General Hospital, Surabaya, and Charity Foundation Program from 2008 to 2015 were reviewed. Detailed patient's demography, clinical findings, radiology results, operative procedures, and complications were documented...
January 5, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29303471/comparison-of-percutaneous-endoscopic-transforaminal-discectomy-microendoscopic-discectomy-and-microdiscectomy-for-symptomatic-lumbar-disc-herniation-minimum-2-year-follow-up-results
#6
Xinyu Liu, Suomao Yuan, Yonghao Tian, Lianlei Wang, Liangtai Gong, Yanping Zheng, Jianmin Li
OBJECTIVE This study aimed to evaluate the clinical outcomes of percutaneous endoscopic transforaminal discectomy (PETD), microendoscopic discectomy (MED), and microdiscectomy (MD) for treatment of symptomatic lumbar disc herniation (LDH). METHODS One hundred ninety-two patients with symptomatic LDH at L3-4 and L4-5 were included in this study. The mean (± SD) age of patients was 34.2 ± 2.6 years (range 18-62 years). The patients were divided into groups as follows: group A was treated with PETD and included 60 patients (31 men and 29 women) with a mean age of 36...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29303458/complications-following-intracranial-pressure-monitoring-in-children-a-6-year-single-center-experience
#7
Ruichong Ma, David Rowland, Andrew Judge, Amedeo Calisto, Jayaratnam Jayamohan, David Johnson, Peter Richards, Shailendra Magdum, Steven Wall
OBJECTIVE Intracranial pressure (ICP) monitoring is an important tool in the neurosurgeon's armamentarium and is used for a wide range of indications. There are many different ICP monitors available, of which fiber-optic intraparenchymal devices are very popular. Here, the authors document their experience performing ICP monitoring from 2005 to 2015 and specifically complication rates following insertion of the Microsensor ICP monitor. METHODS A retrospective case series review of all patients who underwent ICP monitoring over a 10-year period from 2005 to 2015 was performed...
January 5, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29281065/usefulness-of-sealants-for-dural-closure-evaluation-in-an-in-vitro-model
#8
Tristan van Doormaal, Ahmet Kinaci, Sander van Thoor, Saskia Redegeld, Wilhelmina Bergmann, Albert van der Zwan
BACKGROUND: Cerebrospinal fluid (CSF) leakage occurs in 4% to 32% of cranial surgeries and is associated with significant patient burden and expense. The use of sealant as an adjunct to primary dural closure is assumed to help prevent CSF leakage. OBJECTIVE: To examine the utility of different sealants for dural closure using an in Vitro model. METHODS: We evaluated 9 commonly used dural sealants, including Tachosil (Takeda Inc, Osaka, Japan), Adherus (Hyperbranch Inc, Durham, North Carolina), Duraform (Codman, Raynham, Massachusetts), Tissudura (Baxter, Deerfield, Illinois), Hemopatch (Baxter), TissuePatchDural (Tissuemed, Leeds, United Kingdom), Tisseel (Baxter), Duragen Secure (Integra, Plainsboro, New Jersey), and Duraseal, (Integra)...
December 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29279249/reconstruction-of-a-skull-base-defect-after-endoscopic-endonasal-resection-of-a-pituitary-adenoma-sphenoid-mucosal-flaps
#9
Erden Goljo, Eliezer Kinberg, Katelyn Stepan, Jill K Gregory, Alfred M Iloreta, Satish Govindaraj, Hongyan Zou
This report describes a bilateral sphenoid sinus mucosal flap for the repair of a sellar floor defect and CSF leak following endoscopic endonasal skull base surgery. The key advantage of this technique is enabling the sphenoid mucosal flaps to remain vascularized, which reduces postoperative complications including CSF leakage, recurrent sinusitis, meningitis, encephalitis and pneumocephalus. The use of this technique is a viable and possibly favorable alternative to free grafts in the reconstruction of small to medium sized sellar defects with low flow or absent CSF leaks base surgery...
December 20, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29262387/-bath-plug-closure-method-for-cerebrospinal-fluid-leakage-by-endoscopic-endonasal-approach-cooperative-treatment-by-neurosurgeons-and-otolaryngologists
#10
Tomohiro Kawaguchi, Kazuya Arakawa, Kazuhiro Nomura, Yoshikazu Ogawa, Yukio Katori, Teiji Tominaga
Endoscopic endonasal surgery, an innovative surgical technique, is used to approach sinus lesions, lesions of the skull base, and intradural tumors. The cooperation of experienced otolaryngologists and neurosurgeons is important to achieve safe and reliable surgical results. The bath plug closure method is a treatment option for patients with cerebrospinal fluid(CSF)leakage. Although it includes dural and/or intradural procedures, surgery tends to be performed by otolaryngologists because its indications, detailed maneuvers, and pitfalls are not well recognized by neurosurgeons...
December 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29259007/amplification-of-oncolytic-vaccinia-virus-widespread-tumor-cell-killing-by-sunitinib-through-multiple-mechanisms
#11
Minah Kim, Maximilian Nitschké, Barbara Sennino, Patrizia Murer, Brian J Schriver, Alexander M Bell, Aishwarya Subramanian, Corry E McDonald, Jiahu Wang, Howard Cha, Marie-Claude Bourgeois-Daigneault, David H Kirn, John C Bell, Naomi De Silva, Caroline J Breitbach, Donald M McDonald
Oncolytic viruses pose many questions in their use in cancer therapy. In this study, we assessed the potential of mpJX-594 (mouse-prototype JX-594), a replication-competent vaccinia virus administered by intravenous injection, to target the tumor vasculature, produce immune activation and tumor cell killing more widespread than the infection, and suppress invasion and metastasis. These actions were examined in RIP-Tag2 transgenic mice with pancreatic neuroendocrine tumors (PNET) that developed spontaneously and progress as in humans...
December 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29258921/the-choroid-plexus-epithelium-as-a-novel-player-in-the-stomach-brain-axis-during-helicobacter-infection
#12
N Gorlé, C Blaecher, E Bauwens, C Vandendriessche, S Balusu, J Vandewalle, C Van Cauwenberghe, E Van Wonterghem, G Van Imschoot, C Liu, R Ducatelle, C Libert, F Haesebrouck, A Smet, R E Vandenbroucke
Several studies suggest a link between shifts in gut microbiota and neurological disorders. Recently, we reported a high prevalence of Helicobacter suis (H. suis) in patients with Parkinson's disease. Here, we evaluated the effect of gastric H. suis infection on the brain in mice. One month of infection with H. suis resulted in increased brain inflammation, reflected in activation of microglia and cognitive decline. Additionally, we detected choroid plexus inflammation and disruption of the epithelial blood-cerebrospinal fluid (CSF) barrier upon H...
December 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29201836/traumatic-cerebrospinal-fluid-leak-diagnosis-and-management
#13
REVIEW
Ji-Woong Oh, So-Hyun Kim, Kum Whang
Cerebrospinal fluid (CSF) leaks are one of the common complications after traumatic brain injuries (TBI). The risks of CSF leaks can be detrimental to the outcomes of the patients. Early diagnosis and proper management is imperative for it is strongly associated with a better long-term prognosis of the patients. Diagnostic tools for CSF leaks are still under debate. Nevertheless, many reports of successful treatments for CSF leaks have been published with introduction of various repair techniques for leakage sites even though it is surgically challenging...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29191546/patched-closure-of-the-dural-outlet-of-external-ventricular-drainage-catheter-a-better-way-to-prevent-csf-leakage
#14
Wang Kai, Fan Xiaotong, Ren Jian, Wei Yukui, Xu Geng, Shan Yongzhi, Zhao Guoguang
Postoperative continuous bloody cerebral spinal fluid (CSF) drainage with external ventricular drainage catheter could decrease the incidence of inflammation. But the drainage catheter left in place will interrupt the watertight dura matter closure. To prevent the related CSF leakage and subgaleal pseudomeningocele after the catheter removal, we developed a patched closure method to seal the dural outlet of the drainage catheter with a favorable clinical outcome.
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29191537/risk-factors-and-microbiology-of-meningitis-and-or-bacteremia-after-transsphenoidal-surgery-for-pituitary-adenoma
#15
Yu Jin, Xiaohai Liu, Lu Gao, Xiaopeng Guo, Qiang Wang, Xinjie Bao, Kan Deng, Yong Yao, Ming Feng, Wei Lian, Renzhi Wang, Qiwen Yang, Yao Wang, Bing Xing
OBJECTIVE: To investigate the incidence, bacteriological features, and risk factors of post- transsphenoidal surgery (TSS) meningitis and/or bacteremia. METHODS: This retrospective study included 3242 patients who underwent TSS for pituitary adenoma at the Dept. of Neurosurgery of Peking Union Medical College Hospital between January 2012 and December 2016. Clinical data for patients with and without post-TSS meningitis and/or bacteremia were compared and analyzed...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29191390/efficacy-of-intraoperative-lumbar-subarachnoid-drainage-for-prevention-of-cerebrospinal-fluid-leak-after-spinal-cord-tumor-resection
#16
Kazuyoshi Kobayashi, Kei Ando, Kenyu Ito, Mikito Tsushima, Akiyuki Matsumoto, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Naoki Ishiguro, Shiro Imagama
BACKGROUND: Postoperative cerebrospinal fluid (CSF) leakage is a major clinical problem, and prevention of CSF leakage at the surgical site is an important issue. The goal of the study was to evaluate the efficacy of intraoperative lumbar subarachnoid drainage (LSAD) for prevention of CSF leakage after spinal cord tumor resection. METHODS: The subjects were 97 patients with a cervical or thoracic primary intradural spinal cord tumor who underwent surgery at our hospital...
November 27, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29188214/subfrontal-schwannoma-extended-broadly-to-nasal-cavity-treated-by-gamma-knife-radiosurgery-following-surgical-excision-a-case-report
#17
Soo Hee Kim, Jung Hwan Lee, Soon Ki Sung, Chang Hwa Choi
Subfrontal schwannomas are rarely reported. They are usually found only in the subfrontal area, but some extend to the nasal cavity. In these cases, prevention of postoperative cerebrospinal fluid (CSF) leakage through thinned or eroded anterior skull base is important. A 51-year-old female with anosmia and mild nausea was diagnosed as subfrontal extraaxial mass with nasal cavity extension. This mass was initially thought to be an olfactory groove meningioma. We performed a bifrontal craniotomy for surgical excision...
October 2017: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29174229/repair-of-cerebrospinal-fluid-leakage-using-a-transfrontal-radial-adipofascial-flap-an-individual-approach-supported-by-3d-printing-for-surgical-planning
#18
Stefan Grau, Stephanie Kellermann, Michael Faust, Moritz Perrech, Dirk Beutner, Alexander Drzezga, Joachim Zöller
BACKGROUND: Leakage of cerebrospinal fluid (CSF) due to large prolactinomas represents a complex issue. Due to limited anatomical space, often multiple leakage sites and scarce locally available tissue for repair, surgical possibilities are limited. We report an initial case of using a radial fasciocutaneous flap applied sub-frontally to cover a large skull base defect, supported by preoperative 3D-printing for surgical planning. CASE DESCRIPTION: A 29 year old female developed severe nuchal pain which was caused by destruction of large parts of her skull base by a prolactinoma...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29162303/cervical-intradural-disc-herniation-a-systematic-review
#19
REVIEW
Qing Guan, Fei Xing, Ye Long, Zhou Xiang
BACKGROUND: Cervical intradural disc herniation (CIDH) is rare, and diagnosis and treatment are challenging. We conducted a systematic review and meta-analysis of the literature on the diagnosis and treatment of CIDH. METHOD: The presentation, imaging manifestations, diagnosis, management, prognosis and possible pathogenesis were reviewed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English-language studies and case reports published from inception to 2017 were retrieved...
November 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29155344/freehand-technique-for-c2-pedicle-and-pars-screw-placement-safe-or-not
#20
Prachya Punyarat, K Daniel Riew, Benjamin T Klawson, Colleen Peters, Thamrong Lertudomphonwanit, Jacob M Buchowski
BACKGROUND CONTEXT: During placement of C2 pedicle and pars screws, intraoperative fluoroscopy is used so that neurovascular complications can be avoided, and screws can be placed in the proper position. However, this method is time consuming and increases radiation exposure. Furthermore, it does not guarantee completely safe and accurate screw placement. PURPOSE: To evaluate the safety of the C2 pedicle and pars screw placement without fluoroscopic or other guidance methods...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
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