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https://www.readbyqxmd.com/read/28917028/elastic-and-dynamic-properties-of-membrane-phase-field-models
#1
Guillermo R Lázaro, Ignacio Pagonabarraga, Aurora Hernández-Machado
Phase-field models have been extensively used to study interfacial phenomena, from solidification to vesicle dynamics. In this article, we analyze a phase-field model that captures the relevant physical features that characterize biological membranes. We show that the Helfrich theory of elasticity of membranes can be applied to phase-field models, allowing to derive the expressions of the stress tensor, lateral stress profile and elastic moduli. We discuss the relevance and interpretations of these magnitudes from a phase-field perspective...
September 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28916453/making-the-legal-and-ethical-case-for-universal-screening-for-postpartum-mood-and-anxiety-disorders-in-pediatric-primary-care
#2
Amy Lewis Gilbert, Casey Balio, Nerissa S Bauer
Postpartum depression (PPD), part of a larger spectrum of perinatal mood and anxiety disorders, affects up to 15% of women following the birth of an infant. Fathers may also be affected. PPD not only affects caregivers, but also impacts infants through mechanisms such as inadequate caregiver-infant interactions and non-adherence to safety practices. The negative impact on infants may extend across the life course through adulthood. This article seeks to move the needle toward universal screening for PPD using validated tools in pediatric primary care settings for new caregivers by making the legal and ethical case for this course of action in a manner that is both compelling and accessible for clinicians...
September 12, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28915473/endocrine-disrupting-compounds-in-streams-in-israel-and-the-palestinian-west-bank-implications-for-transboundary-basin-management
#3
Pniela Dotan, Maayan Yeshayahu, Wa'd Odeh, Nina Gordon-Kirsch, Ludmila Groisman, Nader Al-Khateeb, Alfred Abed Rabbo, Alon Tal, Shai Arnon
Endocrine disrupting compounds (EDCs) frequently enter surface waters via discharges from wastewater treatment plants (WWTPs), as well as from industrial and agricultural activities, creating environmental and health concerns. In this study, selected EDCs were measured in water and sediments along two transboundary streams flowing from the Palestinian Authority (PA) into Israel (the Zomar-Alexander and Hebron-Beer Sheva Streams). We assessed how the complicated conflict situation between Israel and the PA and the absence of a coordinated strategy and joint stream management commission influence effective EDC control...
September 12, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28913336/anti-interleukin-5-il-5-and-il-5ra-biological-drugs-efficacy-safety-and-future-perspectives-in-severe-eosinophilic-asthma
#4
REVIEW
Diego Bagnasco, Matteo Ferrando, Gilda Varricchi, Francesca Puggioni, Giovanni Passalacqua, Giorgio Walter Canonica
The definition of asthma has changed considerably in recent years, to the extent that asthma is no longer considered a single disease but a heterogeneous disorder that includes several phenotypes and, possibly, endotypes. A more detailed analysis of the immunological mechanisms underlying the pathogenesis of asthma shows interleukin 5 (IL-5) to be a crucial cytokine in several asthma phenotypes. In fact, IL-5 exerts selective action on eosinophils, which, in turn, sustain airway inflammation and worsen asthma symptoms and control...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28910496/using-blogs-to-explore-the-lived-experience-of-life-after-stroke-a-journey-of-discovery-i-never-wanted-to-take
#5
Caroline M Thomas, Rhoda Allison, Jos M Latour
AIMS: To explore the lived-experiences of stroke survivors as expressed in blogs and to discover the role the blogs play in the writers' lives. BACKGROUND: Stroke can be a devastating, life changing event. Previous qualitative studies tend to examine one aspect of life after stroke. As stroke often has multiple effects it is necessary to look widely at its lived-experience. New resources which can enable researchers to explore the lived-experience of stroke are blogs...
September 14, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28910248/parents-online-discussions-about-children-s-dental-caries-a-critical-content-analysis
#6
Avery Milne, Cynthia A Weijs, Rebecca J Haines-Saah, Lindsay McLaren
OBJECTIVES: Through an analysis of postings to an online parenting forum, we aimed to explore the many ways in which parents orient to (i.e., take up, challenge, re-articulate) information about child dental health in the context of their online interactions. Our analysis is anchored in Nettleton's theoretical work on dental authority and power, which we apply in a digital context. METHODS: We examined discussion threads from the public online forums on BabyCenter Canada...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28906024/father-group-leaders-experiences-of-creating-an-arena-for-father-support-a-qualitative-study
#7
Birgitta Kerstis, Michael B Wells, Ewa Andersson
BACKGROUND: Parental classes consisting of only fathers, hereafter referred to as father groups, have existed in Sweden since the mid-1990s. OBJECTIVE: To describe the father group leaders' perspectives on and experiences of father groups. METHOD: A qualitative study was conducted using content analysis. Eleven individual interviews with father group leaders were conducted. An interview guide was used. SETTINGS AND PARTICIPANTS: The study was set in different parts of Sweden...
September 14, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28905883/acceptable-applications-of-preimplantation-genetic-diagnosis-pgd-among-israeli-pgd-users
#8
Shachar Zuckerman, David A Zeevi, Sigal Gooldin, Gheona Altarescu
The use of PGD technology to select against genetic disorders and traits is increasing. Although PGD may eliminate some of the obstacles related to conservative options of prenatal diagnosis, it can raise personal, social and moral questions. Ethical issues concerning the justified uses of PGD are a subject of ongoing debate among medical and bioethical communities. Although attitudes toward the acceptable uses of PGD were evaluated among population groups worldwide, bioethics councils were criticized for ignoring public perspectives...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28905048/social-determinants-of-health-violent-radicalization-and-terrorism-a-public-health-perspective
#9
REVIEW
Héctor E Alcalá, Mienah Zulfacar Sharif, Goleen Samari
Background: Terrorism-related deaths are at an all-time high as there were 32,685 and 29,376 terrorism-related deaths in 2014 and 2015, respectively. Terrorism is defined as the use of violence and intimidation in the pursuit of political aims. Terrorism is detrimental for mental health, premature mortality, and economic losses and undermines the central tenets of public health to improve the health and well-being of populations. Despite the impact terrorism has on avoidable morbidity and mortality, population health research largely overlooks social determinants of terrorism and risk factors that contribute to terrorist activities...
2017: Health Equity
https://www.readbyqxmd.com/read/28903637/helping-others-regulate-emotion-predicts-increased-regulation-of-one-s-own-emotions-and-decreased-symptoms-of-depression
#10
Bruce P Doré, Robert R Morris, Daisy A Burr, Rosalind W Picard, Kevin N Ochsner
Although much research considers how individuals manage their own emotions, less is known about the emotional benefits of regulating the emotions of others. We examined this topic in a 3-week study of an online platform providing training and practice in the social regulation of emotion. We found that participants who engaged more by helping others (vs. sharing and receiving support for their own problems) showed greater decreases in depression, mediated by increased use of reappraisal in daily life. Moreover, social regulation messages with more other-focused language (i...
May 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28903016/arthroscopic-meniscectomy-for-degenerative-meniscal-tears-reduces-knee-pain-but-is-not-cost-effective-in-a-routine-health-care-setting-a-multi-center-longitudinal-observational-study-using-data-from-the-osteoarthritis-initiative
#11
Jan J Rongen, Tim M Govers, Pieter Buma, Maroeska M Rovers, Gerjon Hannink
OBJECTIVES: It is disputed whether arthroscopic meniscectomy is an (cost-) effective treatment for degenerative meniscus tears in day-to-day clinical practice. The objective of this study was to assess the cost-effectiveness of arthroscopic meniscectomy in subjects with knee osteoarthritis, in routine clinical practice, while taking into account the increased risk for future knee replacement surgery. We compared cost-effectiveness of arthroscopic meniscectomy compared to no surgery. DESIGN: - We used a state transition (Markov) simulation model to evaluate the cost-effectiveness of arthroscopic meniscectomy compared to no surgery in subjects with knee osteoarthritis (age range 45- 79 years)...
September 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28901545/teaching-children-with-autism-to-respond-to-disguised-mands
#12
Adel C Najdowski, Ryan Bergstrom, Jonathan Tarbox, Megan St Clair
Children with autism spectrum disorder (ASD) often have difficulty inferring the private events of others, including private verbal behavior (e.g., thoughts), private emotional responses, and private establishing operations, often referred to as "perspective taking" by the general psychology community. Children with ASD also have difficulty responding to disguised mands. Skinner's description of the "disguised mand" is verbal behavior wherein the speaker's mand directly describes neither its reinforcer nor the corresponding establishing operations...
September 13, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28898969/job-specific-mandatory-medical-examinations-for-the-police-force
#13
J S Boschman, C T J Hulshof, M H W Frings-Dresen, J K Sluiter
Background: Mandatory medical examinations (MMEs) of workers should be based on the health and safety requirements that are needed for effectively performing the relevant work. For police personnel in the Netherlands, no job-specific MME exists that takes the specific tasks and duties into account. Aims: To provide the Dutch National Police with a knowledge base for job-specific MMEs for police personnel that will lead to equitable decisions from an occupational health perspective about who can perform police duties...
August 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28898930/impact-and-experiences-of-delayed-discharge-a-mixed-studies-systematic-review
#14
REVIEW
Antonio Rojas-García, Simon Turner, Elena Pizzo, Emma Hudson, James Thomas, Rosalind Raine
BACKGROUND: The impact of delayed discharge on patients, health-care staff and hospital costs has been incompletely characterized. AIM: To systematically review experiences of delay from the perspectives of patients, health professionals and hospitals, and its impact on patients' outcomes and costs. METHODS: Four of the main biomedical databases were searched for the period 2000-2016 (February). Quantitative, qualitative and health economic studies conducted in OECD countries were included...
September 12, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28898301/-notes-for-a-science-of-cannabis
#15
Diego A Golombek
The therapeutic and recreational use of cannabis and its derived products has been known since ancient times. The debate regarding its properties and legal status, which has recently changed in several states, has grown in recent years. However, scientifc evidence for or against its use, as well as for potential toxic effects in the short or long term, is scarce. In spite of the promising perspectives for its therapeutic use, in particular for neurological diseases such as refractory epilepsy or multiple sclerosis, which certainly aim for a controlled administration, this opinion article advocates for a greater incidence of basic and clinical scientifc research that may take this debate further away from matters of belief or prejudice and put it where it belongs, together with evidence and rationality...
November 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28898135/understanding-adolescent-low-back-pain-from-a-multidimensional-perspective-implications-for-management
#16
Peter O'Sullivan, Anne Smith, Darren Beales, Leon Straker
Synopsis Low back pain (LBP) is the leading cause of disability worldwide. It often begins in adolescence, setting a course for later life. We have tracked the time course of LBP in the Raine Study cohort from the age of 14 years into early adulthood. Our work highlights that LBP is already prevalent at 14 years increasing across adolescence and into early adulthood. It is often co-morbid with other musculoskeletal pain. For some adolescents LBP has little impact - while for others its impact includes care seeking, taking medication, taking time off school and work, as well as modifying physical and functional activity...
September 12, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28898057/the-too-many-faces-of-pd-l1-a-comprehensive-conformational-analysis-study
#17
Marawan Ahmed, Khaled H Barakat
In the current study, we focused on the immune-checkpoints PD-1 pathway and in particular on the ligand, PD-L1. We studied the conformational dynamics of PD-L1 through principal component analysis (PCA) of existing crystal structures combined with classical and accelerated molecular dynamics simulations. We identified the maximum structural displacements that take place in all PD-L1 crystal structures and in the MD trajectories. We found that these displacements are attributed to specific flexible regions in the protein...
September 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28895248/nano-star-shaped-polymers-for-drug-delivery-applications
#18
REVIEW
Da-Peng Yang, Ma Nwe Nwe Linn Oo, Gulam Roshan Deen, Zibiao Li, Xian Jun Loh
With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers...
September 12, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28893859/adherens-junctions-and-desmosomes-coordinate-mechanics-and-signaling-to-orchestrate-tissue-morphogenesis-and-function-an-evolutionary-perspective
#19
Matthias Rübsam, Joshua A Broussard, Sara A Wickström, Oxana Nekrasova, Kathleen J Green, Carien M Niessen
Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As such, these intercellular junctions are essential to provide not only integrity to epithelia and other tissues but also the mechanical machinery necessary to execute complex morphogenetic and homeostatic intercellular rearrangements. Moreover, these spatially defined junctions serve as signaling hubs that integrate mechanical and chemical pathways to coordinate tissue architecture with behavior...
September 11, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28893242/how-is-success-achieved-by-individuals-innovating-for-patient-safety-and-quality-in-the-nhs
#20
Laura Sheard, Cath Jackson, Rebecca Lawton
BACKGROUND: Innovation in healthcare is said to be notoriously difficult to achieve and sustain yet simultaneously the health service is under intense pressure to innovate given the ever increasing demands placed upon it. Whilst many studies have looked at diffusion of innovation from an organisational perspective, few have sought to understand how individuals working in healthcare innovate successfully. We took a positive deviance approach to understand how innovations are achieved by individuals working in the NHS...
September 11, 2017: BMC Health Services Research
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