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https://www.readbyqxmd.com/read/29150900/genetic-overlap-between-epilepsy-and-schizophrenia-evidence-from-cross-phenotype-analysis-in-hong-kong-chinese-population
#1
Hongsheng Gui, Miaoxin Li, Pak C Sham, Larry Baum, Patrick Kwan, Stacey S Cherny
Epilepsy and schizophrenia are common and typical neurological or mental illness respectively, and sometimes they comorbid in the same patients, however the underlying genetic relationship between the two brain diseases is still not fully understood. To investigate the possible genetic contribution to their comorbidity, we performed polygenic risk score (PRS) analyses and genetic correlation estimation so as to identify the overall genetic overlap between the two diseases. The global schizophrenia PRS is strongly associated with schizophrenia phenotype in Hong Kong population (odds ratio = 1...
November 17, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29150893/identifying-and-addressing-sexual-health-in-serious%C3%A2-mental-illness-views-of-mental-health-staff-working-in-two-national-health-service-organizations-in-england
#2
Elizabeth Hughes, Amanda J Edmondson, Ijeoma Onyekwe, Chris Quinn, Fiona Nolan
People with serious mental illness (service users) have needs related to sexual health and sexuality, yet these have been poorly addressed in mental health services. In the present study, we report the current practice of mental health professionals in relation to sexual health. Focus groups conducted in two mental health trusts explored routine practice in relation to discussing, assessing, and planning care in relation to sexual health. A thematic analysis identified seven themes: (i) sexual health provision is a complex issue; (ii) mental health staff are aware of sexual health needs; (iii) current provision regarding sexual health is 'neglected'; (iv) barriers to sexual health provision; (v) enabling a discussion around sexual health; (vi) sexual health provision is a role for mental health professionals; and (vii) training needs...
November 18, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29150869/maternal-mood-disorders-and-lithium-exposure-in-utero-were-not-associated-with-poor-cognitive-development-during-childhood
#3
L Forsberg, M Adler, I Römer Ek, M Ljungdahl, L Navér, L L Gustafsson, G Berglund, A Chotigasatien, U Hammar, B Böhm, K Wide
AIM: This study evaluated whether maternal mood disorders, particularly bipolar disorder, and lithium treatment during pregnancy influenced the neonatal health and cognition of children born from 2006- 2010. METHODS: Our study at Karolinska University Hospital, Stockholm, Sweden, focused on women with and without mood disorders and their children. Information on pharmacotherapy, mental health, delivery and neonatal complications was retrospectively collected from electronic patient records...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29150840/longitudinal-pathways-between-mental-health-difficulties-and-academic-performance-during-middle-childhood-and-early-adolescence
#4
Jessica Deighton, Neil Humphrey, Jay Belsky, Jan Boehnke, Panos Vostanis, Praveetha Patalay
There is a growing appreciation that child functioning in different domains, levels, or systems are interrelated over time. Here, we investigate links between internalizing symptoms, externalizing problems, and academic attainment during middle childhood and early adolescence, drawing on two large data sets (child: mean age 8.7 at enrolment, n = 5,878; adolescent: mean age 11.7, n = 6,388). Using a 2-year cross-lag design, we test three hypotheses - adjustment erosion, academic incompetence, and shared risk - while also examining the moderating influence of gender...
November 18, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/29150753/psychological-aspects-of-obesity-in-children-and-adolescents
#5
Rajesh Sagar, Tanu Gupta
Childhood obesity is multi factorial health condition, so the simple evaluation of body fat will not be sufficed to manage the global epidemic of childhood obesity. Literature consistently provides evidence for physical health risks associated with childhood obesity; however in recent times, mental health of the obese children has also gained attention of the researchers as well as clinicians. Obese children experience number of psycho-social problems that significantly affect their quality of life and wellbeing...
November 18, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29150738/the-autism-family-experience-questionnaire-afeq-an-ecologically-valid-parent-nominated-measure-of-family-experience-quality-of-life-and-prioritised-outcomes-for-early-intervention
#6
Kathy Leadbitter, Catherine Aldred, Helen McConachie, Ann Le Couteur, Dharmi Kapadia, Tony Charman, Wendy Macdonald, Erica Salomone, Richard Emsley, Jonathan Green
There is a lack of measures that reflect the intervention priorities of parents of children with autism spectrum disorder (ASD) and that assess the impact of interventions on family experience and quality of life. The Autism Family Experience Questionnaire (AFEQ) was developed through focus groups and online consultation with parents, and reflected parental priorities. It was then administered to the parents of children enrolled in the Pre-school Autism Communication Trial and its 6-year follow-up study. The AFEQ showed good convergent validity with well-established measures of child adaptive functioning, parental mental health and parental wellbeing...
November 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29150295/paternal-transmission-of-early-life-traumatization-through-epigenetics-do-fathers-play-a-role
#7
Enrique d'Harcourt Rowold, Lara Schulze, Sandra Van der Auwera, Hans Jörgen Grabe
Traumatizing events are known to have consequences for the victim which may lead to the development of several well-known mental disorders. Recent research has shown that traumatic events may affect not only the victims' lives, but also that of their progeny. It is generally accepted that this transmission of trauma occurs through parental behavior; however as has been recently discovered, the effects of trauma may also be inherited due to induced alterations in gene expression. These changes, so called epigenetic modifications, illuminate the interaction between genes and the environment...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29150198/comparative-effectiveness-of-extended-release-naltrexone-versus-buprenorphine-naloxone-for-opioid-relapse-prevention-x-bot-a-multicentre-open-label-randomised-controlled-trial
#8
Joshua D Lee, Edward V Nunes, Patricia Novo, Ken Bachrach, Genie L Bailey, Snehal Bhatt, Sarah Farkas, Marc Fishman, Phoebe Gauthier, Candace C Hodgkins, Jacquie King, Robert Lindblad, David Liu, Abigail G Matthews, Jeanine May, K Michelle Peavy, Stephen Ross, Dagmar Salazar, Paul Schkolnik, Dikla Shmueli-Blumberg, Don Stablein, Geetha Subramaniam, John Rotrosen
BACKGROUND: Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and conceptually distinct interventions to prevent opioid relapse. We aimed to estimate the difference in opioid relapse-free survival between XR-NTX and BUP-NX. METHODS: We initiated this 24 week, open-label, randomised controlled, comparative effectiveness trial at eight US community-based inpatient services and followed up participants as outpatients...
November 14, 2017: Lancet
https://www.readbyqxmd.com/read/29150166/exercise-and-mental-health
#9
REVIEW
Kathleen Mikkelsen, Lily Stojanovska, Momir Polenakovic, Marijan Bosevski, Vasso Apostolopoulos
There is a growing body of literature that recognizes the positive effects of exercise on mood states such as anxiety, stress and depression, through physiological and biochemical mechanisms, including endorphins, mitochondria, mammalian target of rapamycin, neurotransmitters and the hypothalamic-pituitary-adrenal axis, and via the thermogenic hypothesis. In addition, psychological mechanisms influence the effects of exercise on mood states, as suggested by both the distraction hypothesis and the self-efficacy hypothesis...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29150139/visual-working-memory-performance-in-aphantasia
#10
Christianne Jacobs, Dietrich S Schwarzkopf, Juha Silvanto
Aphantasia, i.e., the congenital inability to experience voluntary mental imagery, offers a new model for studying the functional role of mental imagery in (visual) cognition. However, until now, there have been no studies investigating whether aphantasia can be linked to specific impairments in cognitive functioning. Here, we assess visual working memory performance in an aphantasic individual. We find that she performs significantly worse than controls on the most difficult (i.e., requiring the highest degree of precision) visual working memory trials...
November 8, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29150038/thoracic-surgery-considerations-in-the-mentally-ill-or-handicapped-patient
#11
REVIEW
Anthony B Mozer, James E Speicher, Carlos J Anciano
Increasing prevalence of mentally ill and handicapped populations requiring surgical thoracic interventions has brought to light their worse associated morbidity and mortality. Baseline functional status, caretaker environment, and mental limitations in day to day life have an impact in the short and long term from these interventions. Aggressive perioperative care, multispecialty approach, technical aspects, palliative procedures, and ethical considerations all play a part in improving outcomes. In this article real cases are presented illustrating points of care and situations for discussion...
February 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29149957/positive-and-negative-affects-in-living-kidney-donors
#12
C-Y Hsieh, C-H Chien, K-L Liu, H-H Wang, K-J Lin, Y-J Chiang
OBJECTIVE: This study aimed to identify the factors influencing the positive and negative affects and the health-related quality of life (HRQOL) of living kidney donors. METHODS: With the use of a cross-sectional study design and a structured questionnaire, information on the basic characteristics, positive affect, negative affect, and HRQOL of 41 living kidney donors were compared. RESULTS: The negative affect in living kidney donors was similar to that of the general population, but the positive affect was slightly lower...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29149915/quality-of-intervention-delivery-in-a-cluster-randomised-controlled-trial-a-qualitative-observational-study-with-lessons-for-fidelity
#13
Karen James, Alan Quirk, Sue Patterson, Geoff Brennan, Duncan Stewart
BACKGROUND: Understanding intervention fidelity is an essential part of the evaluation of complex interventions because fidelity not only affects the validity of trial findings, but also because studies of fidelity can be used to identify barriers and facilitators to successful implementation, and so provide important information about factors likely to impact the uptake of the intervention into clinical practice. Participant observation methods have been identified as being particularly valuable in studies of fidelity, yet are rarely used...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29149903/improving-access-to-school-health-services-as-perceived-by-school-professionals
#14
Janine Bezem, Debbie Heinen, Ria Reis, Simone E Buitendijk, Mattijs E Numans, Paul L Kocken
BACKGROUND: The organisation of health assessments by preventive health services focusing on children's health and educational performance needs to be improved due to evolving health priorities such as mental health problems, reduced budgets and shortages of physicians and nurses. We studied the impact on the school professionals' perception of access to school health services (SHS) when a triage approach was used for population-based health assessments in primary schools. The triage approach involves pre-assessments by SHS assistants, with only those children in need of follow-up being assessed by a physician or nurse...
November 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29149890/physical-activity-and-calorie-intake-mediate-the-relationship-from-depression-to-body-fat-mass-among-female-mexican-health-workers
#15
Amado D Quezada, Nayeli Macías-Waldman, Jorge Salmerón, Tessa Swigart, Katia Gallegos-Carrillo
BACKGROUND: Depression is a foremost cause of morbidity throughout the world and the prevalence of depression in women is about twice as high as men. Additionally, overweight and obesity are major global health concerns. We explored the relationship between depression and body fat, and the role of physical activity and diet as mediators of this relationship in a sample of 456 adult female Mexican health workers. METHOD: Longitudinal and cross-sectional analyses using data from adult women of the Health Workers Cohort Study (HWCS) Measures of body fat mass (kg from DEXA), dietary intake (kcal from FFQ), leisure time activity (METs/wk) and depression (CES-D) were determined in two waves (2004-2006 and 2010-2011)...
November 17, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29149884/predictors-of-early-onset-post-ischemic-stroke-depression-a-cross-sectional-study
#16
Guilin Meng, Xiaoye Ma, Lei Li, Yan Tan, Xiaohui Liu, Xueyuan Liu, Yanxin Zhao
BACKGROUND: Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, clinical, and biochemical factors in patients with PSD. METHODS: Patients with an acute ischemic stroke, who met the inclusion criteria at Shanghai Tenth People's Hospital from April 2016 to September 2016, were recruited for this study. The stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), and the mental state was assessed using Mini-Mental State Examination (MMSE), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) at 1 week of admission...
November 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29149850/a-cross-sectional-examination-of-psychological-distress-positive-mental-health-and-their-predictors-in-medical-students-in-their-clinical-clerkships
#17
Inge van Dijk, Peter L B J Lucassen, Chris van Weel, Anne E M Speckens
BACKGROUND: Medical students can experience the transition from theory to clinical clerkships as stressful. Scientific literature on the mental health of clinical clerkship students is scarce and mental health is usually defined as absence of psychological distress without assessing psychological, emotional and social wellbeing, together called 'positive mental health'. This cross-sectional study examines the prevalence of psychological distress and positive mental health and explores possible predictors in a Dutch sample of clinical clerkship students...
November 17, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29149797/findings-from-a-strength-based-moderate-intensity-exercise-interventions-for-individuals-with-dementia-innovative-practice
#18
Nicole Dawson, Hayden Gerhart, Katherine S Judge
Limited evidence exists regarding exercise interventions with individuals with dementia, which is often due to heterogeneity of methodology and outcomes being assessed. This led to the development and evaluation of a moderate-intensity home-based functional exercise program guided by theories from exercise science and the Strength-Based Approach. Data indicated excellent treatment adherence (99.04%) along with high levels of acceptability and feasibility in this sample (age 76.63 years (9.84); Mini Mental State Exam 18...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149717/usefulness-of-the-montreal-cognitive-assessment-moca-to-monitor-cognitive-impairments-in-depressed-patients-receiving-electroconvulsive-therapy
#19
Rémi Moirand, Filipe Galvao, Maxime Lecompte, Emmanuel Poulet, Frédéric Haesebaert, Jerome Brunelin
There is a lack of consensual tools for evaluating the cognitive side-effects in patients with depression who are treated with electroconvulsive therapy (ECT). The objective of this study was to evaluate the usefulness of the Montreal Cognitive Assessment (MoCA) and of the Mini Mental State Examination (MMSE) to monitor cognitive changes in patients with depression receiving ECT. Cognitive functioning was assessed prospectively in 48 patients with unipolar or bipolar depression before and after an ECT course...
November 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29149654/classifying-binge-eating-disordered-adolescents-based-on-severity-levels
#20
Antonios Dakanalis, Maria Assunta Zanetti, Fabrizia Colmegna, Giuseppe Riva, Massimo Clerici
The new severity criterion for binge-eating disorder (BED), introduced by the most recent (fifth) edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as a means of addressing within-group variability in severity, was tested in 223 Italian (13-18-year-old) adolescents (86.1% females) with (DSM-5) BED presenting for treatment. Analyses revealed that participants classified with mild (35.9% of the sample), moderate (38.1%) severe (13.4%), and extreme (12.6%) severity of BED, based on their clinician-rated weekly frequency of binge-eating (BE) episodes, were statistically distinguishable in physical characteristics (body mass index) and a range of clinical variables regarding eating-related psychopathology and putative maintenance factors, health-related quality of life, and mood and anxiety disorder comorbidity (medium-to-large effect sizes)...
November 14, 2017: Journal of Adolescence
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