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https://www.readbyqxmd.com/read/28324976/meandered-conformai-antenna-for-ism-band-ingestible-capsule-communication-systems
#1
Md Shamsul Arefin, Jean-Michel Redoute, Mehmet Rasit Yuce
The wireless capsule has been used to measure physiological parameters in the gastrointestinal tract where communication from in-body to external receiver is necessary using a miniaturized antenna with high gain and onmidirectional radiation pattern. This paper presents a meandered conformal antenna with center frequency of 433 MHz for a wireless link between an in-body capsule system and an ex-body receiver system. The antenna is wrapped around the wireless capsule, which provides extra space for other circuits and sensors inside the capsule as well as allows it having larger dimensions compared to inner antennas...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324871/herd-specific-random-regression-carcass-profiles-for-beef-cattle-after-adjustment-for-animal-genetic-merit
#2
Tanya M Englishby, Kirsty L Moore, Donagh P Berry, Mike P Coffey, Georgios Banos
Abattoir data are an important source of information for the genetic evaluation of carcass traits, but also for on-farm management purposes. The present study aimed to quantify the contribution of herd environment to beef carcass characteristics (weight, conformation score and fat score) with particular emphasis on generating finishing herd-specific profiles for these traits across different ages at slaughter. Abattoir records from 46,115 heifers and 78,790 steers aged between 360 and 900days, and from 22,971 young bulls aged between 360 and 720days, were analysed...
March 7, 2017: Meat Science
https://www.readbyqxmd.com/read/28324869/applications-of-high-pressure-to-pre-rigor-rabbit-muscles-affect-the-functional-properties-associated-with-heat-induced-gelation
#3
Siwen Xue, Huijuan Yang, Rui Liu, Chang Qian, Mengyao Wang, Yufeng Zou, Xinglian Xu, Guanghong Zhou
High pressure (HP) was applied to pre-rigor rabbit muscles (PRRMs) for the manufacture of value-added gel-type products. A 2×3 factorial design was adopted for HP-treatment (100, 200 and 300MPa for 15 or 180s) to PRRMs. The HP-treated meat was used for gel preparation and determination of water mobility properties and textural profiles. Salt-soluble meat proteins (SSMP) were then extracted from meat for estimating the tertiary conformational changes (hydrophobic and sulfhydryl groups). The water-holding capacity of treated samples increased significantly (P<0...
March 10, 2017: Meat Science
https://www.readbyqxmd.com/read/28324771/synthesis-and-conformational-analysis-of-a-simplified-inositol-model-of-the-streptococcus-pneumoniae-19f-capsular-polysaccharide-repeating-unit
#4
Giorgio Catelani, Felicia D'Andrea, Lorenzo Guazzelli, Alessio Griselli, Nicola Testi, Maria Assunta Chiacchio, Laura Legnani, Lucio Toma
Carbohydrate mimics have been studied for a long time as useful sugar substitutes, both in the investigation of biological events and in the treatment of sugar-related diseases. Here we report further evaluation of the capabilities of inositols as carbohydrate substitutes. The conformational features of an inositol-model of a simplified repeating unit corresponding to the capsular polysaccharide of Streptococcus pneumoniae 19F has been evaluated by computational analysis, and compared to the native repeating unit...
March 14, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28324692/influence-of-graphene-oxide-and-reduced-graphene-oxide-on-the-activity-and-conformation-of-lysozyme
#5
Yitong Bai, Zhu Ming, Yuye Cao, Shicheng Feng, Hua Yang, Lingyun Chen, Sheng-Tao Yang
The dramatically different bio-effects of graphene and graphene oxide (GO) have been widely observed in diverse biological systems, which determine the applications and toxicity of graphene materials. To elucidate the mechanism at molecular level, it is urgent to investigate the enzyme-graphene interaction and its consequences. In this study, we comparatively studied the influence of GO and reduced GO (RGO) on the activity and conformation of lysozyme to provide better understandings of their different bio-effects...
March 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28324510/analysis-of-telomere-homologous-dna-with-different-conformations-using-2d-agarose-electrophoresis-and-in-gel-hybridization
#6
Zepeng Zhang, Qian Hu, Yong Zhao
In mammalian cells, in addition to double-stranded telomeric DNA at chromosome ends, extra telomere-homologous DNA is present that adopts different conformations, including single-stranded G- or C-rich DNA, extrachromosomal circular DNA (T-circle), and telomeric complex (T-complex) with an unidentified structure. The formation of such telomere-homologous DNA is closely related to telomeric DNA metabolism and chromosome end protection by telomeres. Conventional agarose gel electrophoresis is unable to separate DNA based on conformation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28324242/numerical-insights-into-the-phase-diagram-of-p-atic-membranes-with-spherical-topology
#7
A G Hansen, N Ramakrishnan, P B Sunil Kumar, J H Ipsen
The properties of self-avoiding p-atic membranes restricted to spherical topology have been studied by Monte Carlo simulations of a triangulated random surface model. Spherically shaped p-atic membranes undergo a Kosterlitz-Thouless transition as expected with topology induced mutually repelling disclinations of the p-atic ordered phase. For flexible membranes the phase behaviour bears some resemblance to the spherically shaped case with a p-atic disordered crumpled phase and p-atic ordered, conformationally ordered (crinkled) phase separated by a KT-like transition with proliferation of disclinations...
March 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28323494/associations-between-thematic-content-and-industry-self-regulation-code-violations-in-beer-advertising-broadcast-during-the-u-s-ncaa-basketball-tournament
#8
Jonathan K Noel, Ziming Xuan, Thomas F Babor
BACKGROUND: Beer marketing in the United States is controlled through self-regulation, whereby the beer industry has created a marketing code and enforces its use. We performed a thematic content analysis on beer ads broadcast during a U.S. college athletic event and determined which themes are associated with violations of a self-regulated alcohol marketing code. METHODS: 289 beer ads broadcast during the U.S. NCAA Men's and Women's 1999-2008 basketball tournaments were assessed for the presence of 23 thematic content areas...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28323432/electronic-structures-and-oh-induced-atmospheric-degradation-of-cf3nsf2-a-potential-green-dielectric-replacement-for-sf6
#9
Lin Cheng, Xiaojuan Yu, Kun Zhao, Hua Hou, Baoshan Wang
Electronic structures of Trifluoromethyl imionosulfur difluoride (CF3NSF2) and degradation mechanisms by hydroxyl radical have been investigated using density functional theory (M06-2X), the complete basis set quadratic CBS-Q, and the explicitly correlated coupled-cluster methods [CCSD(T)-F12]. The d-function augmented Correlation-consistent basis sets including triple- and quadruple- were employed for the sulfur-containing species. It was found that CF3NSF2 exists as two conformations connected by the internal rotation of CF3 around the central NS bond...
March 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28319903/fe-iii-based-metal-organic-framework-derived-core-shell-nanostructure-sensitive-electrochemical-platform-for-high-trace-determination-of-heavy-metal-ions
#10
Zhihong Zhang, Hongfei Ji, Yingpan Song, Shuai Zhang, Minghua Wang, Changchang Jia, Jia-Yue Tian, Linghao He, Xiaojing Zhang, Chun-Sen Liu
A new core-shell nanostructured composite composed of Fe(III)-based metal-organic framework (Fe-MOF) and mesoporous Fe3O4@C nanocapsules (denoted as Fe-MOF@mFe3O4@mC) was synthesized and developed as a platform for determining trace heavy metal ions in aqueous solution. Herein, the mFe3O4@mC nanocapsules were prepared by calcining the hollow Fe3O4@C that was obtained using the SiO2 nanoparticles as the template, followed by composing the Fe-MOF. The Fe-MOF@mFe3O4@mC nanocomposite demonstrated excellent electrochemical activity, water stability and high specific surface area, consequently resulting in the strong biobinding with heavy-metal-ion-targeted aptamer strands...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319868/synthesis-characterization-of-amide-substituted-dexibuprofen-derivatives-and-their-spectral-voltammetric-and-docking-investigations-for-dna-binding-interactions
#11
Nasima Arshad, Muhammad Zafran, Zaman Ashraf, Fouzia Perveen
Three amide derivatives - methyl-2-[2-(4-isobutylphenyl)propanamido]propanoate (Dex-2), methyl 2-[2-(4-isobutylphenyl) propanamido]-3-phenylpropanoate (Dex-3) and methyl 2-[2-(4-isobutylphenyl)-propanamido]-4-methylpentanoate (Dex-4) of dexibuprofen (Dex-1) 2-(4-isobutylphenyl)propanoic acid were synthesized and conformed for structures by physical data and spectral analysis. Further, all the compounds were studied for their binding with ds.DNA through experimental (UV-visible/and fluorescence spectroscopy, cyclic voltammetry) and theoretical (molecular docking) techniques...
March 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28319811/protein-epitope-mimetic-macrocycles-as-biopharmaceuticals
#12
REVIEW
Anatol Luther, Kerstin Moehle, Eric Chevalier, Glenn Dale, Daniel Obrecht
Fully synthetic medium-sized macrocyclic peptides mimicking the key β-hairpin and α-helical protein epitopes relevant in many protein-protein interactions have emerged as a novel class of drugs with the potential to fill an important gap between small molecules and proteins. Conformationally stabilized macrocyclic scaffolds represent ideal templates for medicinal chemists to incorporate bioactive peptide and protein pharmacophores in order to generate novel drugs to treat diseases with high unmet medical need...
March 5, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28319781/systematic-study-of-imidazoles-inhibiting-ido1-via-the-integration-of-molecular-mechanics-and-quantum-mechanics-calculations
#13
Yi Zou, Fang Wang, Yan Wang, Wenjie Guo, Yihua Zhang, Qiang Xu, Yisheng Lai
Indoleamine 2,3-dioxygenase 1 (IDO1) is regarded as an attractive target for cancer immunotherapy. To rationalize the detailed interactions between IDO1 and its inhibitors at the atomic level, an integrated computational approach by combining molecular mechanics and quantum mechanics methods was employed in this report. Specifically, the binding modes of 20 inhibitors was initially investigated using the induced fit docking (IFD) protocol, which outperformed other two docking protocols in terms of correctly predicting ligand conformations...
March 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28319773/potential-of-water-washing-of-rape-straw-on-thermal-properties-and-interactions-during-co-combustion-with-bituminous-coal
#14
Qiulin Ma, Lujia Han, Guangqun Huang
The aim of this work was to study the thermal properties and interactions during co-combustion of rape straw (RS) before and after water-washing with bituminous coal. A series of experiments was conducted to investigate the properties and interactions during co-combustion of RS with bituminous coal (at 10, 20, 40 and 60% RS). The feasibility and potential of water-washing as an RS pre-treatment was also explored. Reactivity and the amount of heat released followed a quadratic trend, while changes to the degree of interactions between the fuels conformed to a cosine curve...
March 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28319659/improving-computational-predictions-of-single-stranded-rna-tetramers-with-revised-%C3%AE-%C3%AE-torsional-parameters-for-the-amber-force-field
#15
David J Wales, Ilyas Yildirim
With current advancements in RNA based therapeutics, it is becoming crucial to utilize theoretical and computational methods to describe properly the physical properties of RNA molecules. NMR and X-ray crystallography are two powerful techniques for investigating structural properties. However, if the RNA molecules are complex or dynamic, these methods might not be adequate. For computational approaches, the quality of the force field will determine accuracy of our predictions. In this contribution, we revise the α/γ torsional parameters of RNA for amber force field using a model system representing an RNA dimer backbone...
March 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28319394/a-network-of-conformational-transitions-in-the-apo-form-of-ndm-1-enzyme-revealed-by-md-simulation-and-a-markov-state-model
#16
Kaifu Gao, Yunjie Zhao
New Delhi metallo-β-lactamase-1 (NDM-1) is a novel β-Lactamase enzyme that confers enteric bacteria with nearly complete resistance to all β-lactam antibiotics, so raises a formidable and global threat to human health. However, the binding mechanism between apo-NDM-1 and antibiotics as well as related conformational changes remains poorly understood, which largely hinders the overcoming of its antibiotic resistance. In our study, long-time conventional molecular dynamics simulation and Markov state models were applied to reveal both dynamical and conformational landscape of apo-NDM-1: the MD simulation demonstrates that the loop L3, which is responsible for antibiotic binding, is the most flexible and undergoes dramatic conformational changes; moreover, the Markov state model built from the simulation maps four metastable states including open, semi-open and closed conformations of the loop L3 as well as frequent transitions between the states...
March 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28319378/computational-study-of-13c-nmr-csa-patterns-in-c20h10-and-c20h10-4-insights-into-their-variation-upon-planarization-and-formation-of-concentric-aromatic-species-in-the-smaller-isolated-pentagon-structural-motif
#17
Alvaro Muñoz-Castro, Wilson Caimanque-Aguilar, Cesar Morales-Verdejo
Corannulene, C20H10, exhibits a concave surface in the ground state which is able to experience a bowl-to-bowl inversion through a planar conformation. Such structure is the smaller example resembling an isolated-pentagon motif, as a relevant fragment in Fullerene chemistry. Here, we explored the differences between bowl and planar conformations involving both energetic and 13C-NMR properties, for the neutral and tetraanionic species by using DFT methods. This allows to understand the variation of the chemical environment at the carbon atoms upon planarization of this representive motif...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28319334/biofunctionalized-plants-as-diverse-biomaterials-for-human-cell-culture
#18
Gianluca Fontana, Joshua Gershlak, Michal Adamski, Jae-Sung Lee, Shion Matsumoto, Hau D Le, Bernard Binder, John Wirth, Glenn Gaudette, William L Murphy
The commercial success of tissue engineering products requires efficacy, cost effectiveness, and the possibility of scaleup. Advances in tissue engineering require increased sophistication in the design of biomaterials, often challenging the current manufacturing techniques. Interestingly, several of the properties that are desirable for biomaterial design are embodied in the structure and function of plants. This study demonstrates that decellularized plant tissues can be used as adaptable scaffolds for culture of human cells...
March 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28319298/diversity-in-gold-finger-structure-elucidated-by-traveling-wave-ion-mobility-mass-spectrometry
#19
Zhifeng Du, Raphael E F de Paiva, Kristina Nelson, Nicholas P Farrell
Traveling wave ion mobility (TWIM) mass spectrometry (MS) is a powerful method for the structural and conformational analysis of proteins and peptides, enabling the differentiation of isomeric peptides (or proteins) that have the same sequence but are modified at different residues. In this study, the TWIM-MS technique was used to separate isomeric Au(I) metallopeptide ions that were formed by Zn(II) displacement from the parent zinc fingers (ZFs). The synthetic gold finger peptides were derived from the C-terminus of the HIV nucleocapsid p7 protein (NCp7-F2) and finger 3 of the Sp1 transcription factor (Sp1-F3)...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28319136/structural-insights-into-the-regulation-of-bacillus-subtilis-sigw-activity-by-anti-sigma-rsiw
#20
Shankar Raj Devkota, Eunju Kwon, Sung Chul Ha, Hyeun Wook Chang, Dong Young Kim
Bacillus subtilis SigW is localized to the cell membrane and is inactivated by the tight interaction with anti-sigma RsiW under normal growth conditions. Whereas SigW is discharged from RsiW binding and thus initiates the transcription of its regulon under diverse stress conditions such as antibiotics and alkaline shock. The release and activation of SigW in response to extracytoplasmic signals is induced by the regulated intramembrane proteolysis of RsiW. As a ZAS (Zinc-containing anti-sigma) family protein, RsiW has a CHCC zinc binding motif, which implies that its anti-sigma activity may be regulated by the state of zinc coordination in addition to the proteolytic cleavage of RsiW...
2017: PloS One
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