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https://www.readbyqxmd.com/read/28550700/optimizing-transitions-of-care-hospital-to-community
#1
Emily Sheridan, Christine Thompson, Tania Pinheiro, Nicole Robinson, Karen Davies, Nancy Whitmore
Discharging patients from the hospital is a complex process, and preventing avoidable readmissions has the potential to improve both the quality of life for patients and the financial sustainability of the healthcare system (Alper et al. 2016). Improving the discharge process is one method to mitigate readmission to the hospital. Historically, St. Thomas Elgin General Hospital (STEGH) consistently experienced higher-than-expected readmission rates, and only 41% of discharge summaries were sent from the hospital to the community primary care within 48 hours...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28545198/assessing-breast-cancer-awareness-in-thai-women-validation-of-the-breast-cancer-awareness-scale-b-cas
#2
Nitchamon Rakkapao, Supannee Promthet, Malcolm Anthony Moore, Solikhah Solikhah, Cameron Hurst
Background: Raising breast cancer awareness is a well-established first line strategy to reduce breast cancer mortality. A properly validated instrument is needed to gain a better understanding of breast cancer awareness. Objective: The objective of this study was to develop and validate an instrument to assess breast cancer awareness in Thai women. Methods: In this study, we develop and evaluate the validity of the Breast Cancer Awareness Scale (B-CAS). Construct validity was evaluated by using exploratory factor analysis and confirmatory factor analysis, and criterion validity was investigated using ROC curves to examine the associations between B-CAS subscales and breast self-examination...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28543738/crispr-editing-in-biological-and-biomedical-investigation
#3
Xing-Da Ju, Jing Xu, Zhong Sheng Sun
The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas (CRISPR--associated protein) system, a prokaryotic RNA-based adaptive immune system against viral infection, is emerging as a powerful genome editing tool in broad research areas. To further improve and expand its functionality, various CRISPR delivery strategies have been tested and optimized, and key CRISPR system components such as Cas protein have been engineered with different purposes. Benefiting from more in-depth understanding and further development of CRISPR, versatile CRISPR-based platforms for genome editing have been rapidly developed to advance investigations in biology and biomedicine...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542527/genomic-and-transcriptomic-analyses-reveal-adaptation-mechanisms-of-an-acidithiobacillus-ferrivorans-strain-yl15-to-alpine-acid-mine-drainage
#4
Tangjian Peng, Liyuan Ma, Xue Feng, Jiemeng Tao, Meihua Nan, Yuandong Liu, Jiaokun Li, Li Shen, Xueling Wu, Runlan Yu, Xueduan Liu, Guanzhou Qiu, Weimin Zeng
Acidithiobacillus ferrivorans is an acidophile that often occurs in low temperature acid mine drainage, e.g., that located at high altitude. Being able to inhabit the extreme environment, the bacterium must possess strategies to copy with the survival stress. Nonetheless, information on the strategies is in demand. Here, genomic and transcriptomic assays were performed to illuminate the adaptation mechanisms of an A. ferrivorans strain YL15, to the alpine acid mine drainage environment in Yulong copper mine in southwest China...
2017: PloS One
https://www.readbyqxmd.com/read/28540719/one-step-toward-a-new-generation-of-c-mos-compatible-oxide-p-n-junctions-structure-of-the-lsmo-zno-interface-elucidated-by-an-experimental-and-theoretical-synergic-work
#5
Daniele Pullini, Mauro Francesco Sgroi, Agnes Nora Mahmoud, Nicolas Gauquelin, Lorenzo Maschio, Anna Maria Ferrari, Rik Groenen, Cas Damen, Guus Rijnders, Karel H W van den Bos, Sandra Van Aert, Johan Verbeeck
Heterostructures formed by La0.7Sr0.3MnO3/ZnO (LSMO/ZnO) interfaces exhibit extremely interesting electronic properties making them promising candidatea for novel oxide p-n junctions with multifunctional features. In this work, the structure of the interface is studied through a combined experimental/theoretical approach, . Hetero-structures were grown epitaxially and homogeneously on 4" silicon wafers, characterized by advanced electron microscopy imaging and spectroscopy, and simulated by ab-initio DFT calculations...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28540365/the-role-of-apoptotic-factors-in-assessing-progression-of-periodontal-disease
#6
D Dabiri, S Halubai, M Layher, C Klausner, H Makhoul, G H Lin, G Eckert, H Abuhussein, P Kamarajan, Y Kapila
BACKGROUND: The mechanisms responsible for periodontal disease progression remain unclear. However, recent studies suggest that apoptosis may be one mechanism underlying the pathophysiology of periodontal disease progression. This pilot study is the 3 month follow-up of our published baseline study on the presence of apoptotic factors in serum, saliva, and gingival crevicular fluid (GCF) and their association with periodontal disease severity and activity. METHODS: GCF samples were obtained from 37 adult patients with chronic periodontitis (CP) and 7 healthy controls...
September 2016: Int J Dent Oral Sci
https://www.readbyqxmd.com/read/28539213/medical-management-of-asymptomatic-carotid-artery-stenosis
#7
REVIEW
Aaron W Aday, Joshua A Beckman
Carotid artery atherosclerosis is a major risk factor for both stroke and cardiovascular disease. Appropriate management of asymptomatic patients with carotid artery stenosis (CAS) remains unclear. Although several randomized clinical trials support revascularization in asymptomatic patients with severe CAS to reduce stroke risk, the participants in these trials did not receive optimal medical therapy (OMT) by today's standards. For many individuals, medical therapy may provide excellent risk reduction without the periprocedural risk of endarterectomy or stenting...
May 21, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/28538609/critical-care-interventions-for-asthmatic-patients-admitted-from-the-emergency-department-to-the-pediatric-intensive-care-unit
#8
Kristen Michelle Cundiff, James M Gerard, Robert G Flood
OBJECTIVES: The aim of this study was to assess the frequency and predictors of critical interventions in asthmatic patients admitted to the pediatric intensive care unit (PICU) at a tertiary-care pediatric hospital. METHODS: We conducted a retrospective chart review of patients admitted from our emergency department (ED) to the PICU for treatment of status asthmaticus between January 1, 2008, and March 31, 2013. Patients with concomitant medical conditions and those who received a critical intervention, other than continuously aerosolized albuterol, in the ED before admission were excluded...
May 23, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28538522/frequency-specificity-and-left-ear-advantage-of-medial-olivocochlear-efferent-modulation-a-study-based-on-stimulus-frequency-otoacoustic-emission
#9
Dongjia Xing, Qin Gong
The medial olivocochlear (MOC) bundle is an auditory nucleus that projects efferent nerve fibers to the outer hair cells (OHCs) for synaptic innervation. The aim of the present study was to investigate the possible existence of frequency and ear specificity in MOC efferent modulation, as well as how MOC activation influences cochlear tuning. Stimulus frequency otoacoustic emissions (SFOAEs) were used to study MOC efferent modulation. Therefore, the current experiment was designed to compare the degree of SFOAE suppression in the both ears of 20 individuals at 1, 2, 4, and 8 kHz...
May 19, 2017: Neuroreport
https://www.readbyqxmd.com/read/28536898/impact-of-tissue-adhesives-on-the-prevention-of-anastomotic-leakage-of-colonic-anastomoses-an-in-vivo-study
#10
Konstantinos A Vakalopoulos, Joanna W A M Bosmans, Kevin W Y van Barneveld, Ruben R M Vogels, Geesien S A Boersema, Zhouqiao Wu, Marion J J Gijbels, Johannes Jeekel, Gert-Jan Kleinrensink, Nicole D Bouvy, Johan F Lange
BACKGROUND: Tissue adhesives (TA) may be useful to strengthen colorectal anastomoses, thereby preventing anastomotic leakage (AL). Previous studies have identified cyanoacrylate (CA) TAs as the most promising colonic anastomotic sealants. This study investigates the protective effects of sealing colonic anastomoses with various CAs. MATERIALS AND METHODS: Fifty-five Wistar rats underwent laparotomy and transection of the proximal colon. An anastomosis was created with 4 interrupted sutures followed by either application of Histoacryl Flexible, Omnex, Glubran 2, or no TA seal...
May 23, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28536069/crispr-engineered-genome-editing-for-the-next-generation-neurological-disease-modeling
#11
REVIEW
Weijun Feng, Hai-Kun Liu, Daisuke Kawauchi
Neurological disorders often occur because of failure of proper brain development and/or appropriate maintenance of neuronal circuits. In order to understand roles of causative factors (e.g. genes, cell types) in disease development, generation of solid animal models has been one of straight-forward approaches. Recent next generation sequencing studies on human patient-derived clinical samples have identified various types of recurrent mutations in individual neurological diseases. While these discoveries have prompted us to evaluate contribution of mutated genes to these neurological diseases, a feasible but flexible genome editing tool had remained to be developed...
May 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28535951/experimental-hydrophilic-vinyl-polysiloxane-vps-impression-materials-incorporating-a-novel-surfactant-compared-with-commercial-vps
#12
Shahab Ud Din, Sandra Parker, Michael Braden, Pete Tomlins, Mangala Patel
OBJECTIVES: To formulate experimental hydrophilic (Exp) VPS impression materials incorporating a novel surfactant (Rhodasurf CET-2), and to compare their contact angles (CAs) with commercial materials, before/after disinfection. METHODS: CAs were measured immediately after setting and after disinfection (1% NaOCl; 30min and 24h), together with their change whilst a droplet remained on the materials surface (over 10, 20, 30 60 and 120s), on three commercial (Aquasil Ultra-Monophase [Aq M], Elite HD-Monophase [Elt M], Extrude Medium-bodied [Extr M]) and four experimental (Exp I-IV) materials, using the Drop Shape Analysis 100 technique...
May 20, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28535195/presence-of-type-i-f-crispr-cas-systems-is-associated-with-antimicrobial-susceptibility-in-escherichia-coli
#13
Seyid Aydin, Yoann Personne, Enas Newire, Rebecca Laverick, Oliver Russell, Adam P Roberts, Virve I Enne
Background: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and their associated cas genes are sequence-specific DNA nuclease systems found in bacteria and archaea. CRISPR/Cas systems use RNA transcripts of previously acquired DNA (spacers) to target invading genetic elements with the same sequence, including plasmids. In this research we studied the relationship between CRISPR/Cas systems and multidrug resistance in Escherichia coli . Methods: The presence of Type I-E and Type I-F CRISPR systems was investigated among 82 antimicrobial-susceptible and 96 MDR clinical E...
May 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28534435/genome-editing-technologies-and-patent-landscape-overview
#14
Fairouz Benahmed-Miniuk, Mat Kresz, Jitendra K Kanaujiya, Christopher D Southgate
Unlike with zinc finger nuclease and transcriptional activator-like effector nuclease DNA modification technologies that rely on lead proteins, developed through expensive and time-consuming processes, the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system has rapidly emerged as the most promising gene-editing technology to date for the modification of any selected DNA sequence. CRISPR is receiving tremendous fanfare due, in part, to its potential to provide a means to fundamentally alter medical genetics and especially cancer medicine...
May 23, 2017: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/28534256/crispr-cas9-mediated-correction-of-human-genetic-disease
#15
REVIEW
Ke Men, Xingmei Duan, Zhiyao He, Yang Yang, Shaohua Yao, Yuquan Wei
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) protein 9 system (CRISPR/Cas9) provides a powerful tool for targeted genetic editing. Directed by programmable sequence-specific RNAs, this system introduces cleavage and double-stranded breaks at target sites precisely. Compared to previously developed targeted nucleases, the CRISPR/Cas9 system demonstrates several promising advantages, including simplicity, high specificity, and efficiency. Several broad genome-editing studies with the CRISPR/Cas9 system in different species in vivo and ex vivo have indicated its strong potential, raising hopes for therapeutic genome editing in clinical settings...
May 3, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28533129/rifm-fragrance-ingredient-safety-assessment-butyl-anthranilate-cas-registry-number-7756-96-9
#16
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, S L A Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
May 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28533078/simulation-of-carotid-artery-stenting-reduces-training-procedure-and-fluoroscopy-times
#17
Andre F Gosling, Daniel E Kendrick, Ann H Kim, Anil Nagavalli, Ethan S Kimball, Nathaniel T Liu, Vikram S Kashyap, John C Wang
OBJECTIVE: Outcomes from carotid artery stenting (CAS) are related to experience and technical expertise of the operator. Simulation of CAS may enhance clinical proficiency. We interrogated the impact of endovascular simulation of CAS procedures in operators who are at various stages of training. METHODS: Twelve trainees (students [n = 4]; junior surgery residents, postgraduate year [PGY] 1-3 [n = 4]; and senior surgery residents or fellows, PGY 4-7 [n = 4]) were apprised of characteristics of an endovascular simulator and CAS procedures...
May 19, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28532598/crispr-cpf1-a-new-tool-for-plant-genome-editing
#18
Syed Shan-E-Ali Zaidi, Magdy M Mahfouz, Shahid Mansoor
Clustered regularly interspaced palindromic repeats (CRISPR)-CRISPR-associated proteins (CRISPR-Cas), a groundbreaking genome-engineering tool, has facilitated targeted trait improvement in plants. Recently, CRISPR-CRISPR from Prevotella and Francisella 1 (Cpf1) has emerged as a new tool for efficient genome editing, including DNA-free editing in plants, with higher efficiency, specificity, and potentially wider applications than CRISPR-Cas9.
May 19, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28531959/occurrence-and-removal-of-pharmaceuticals-hormones-personal-care-products-and-endocrine-disrupters-in-a-full-scale-water-reclamation-plant
#19
Ngoc Han Tran, Karina Yew-Hoong Gin
This study provided the first comprehensive data on the occurrence and removal of twenty-five target emerging contaminants (ECs) in a full-scale water reclamation plant (WRP) in the Southeast Asian region. Nineteen out of the twenty-five ECs were ubiquitously detected in raw influent samples. Concentrations of the detected ECs in raw influent samples ranged substantially from 44.3 to 124,966ng/L, depending upon the compound and sampling date. The elimination of ECs in full-scale conventional activated sludge (CAS) and membrane bioreactor (MBR) systems at a local WRP was evaluated and compared...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531107/analysis-of-gene-expression-signatures-in-cancer-associated-stroma-from-canine-mammary-tumours-reveals-molecular-homology-to-human-breast-carcinomas
#20
Julia Ettlin, Elena Clementi, Parisa Amini, Alexandra Malbon, Enni Markkanen
Cancer-associated stroma (CAS) plays a key role in cancer initiation and progression. Spontaneously occurring canine mammary carcinomas are viewed as excellent models of human breast carcinomas. Considering the importance of CAS for human cancer, it likely plays a central role in canine tumours as well. So far, however, canine CAS lacks characterisation, and it remains unclear whether the biology between CAS from canine and human tumours is comparable. In this proof-of-principle study, using laser-capture microdissection, we isolated CAS and normal stroma from 13 formalin-fixed paraffin embedded canine simple mammary carcinomas and analysed the expression of seven known human CAS markers by RT-qPCR (Reverse Transcription quantitative PCR) and validated some targets by immunohistochemistry...
May 20, 2017: International Journal of Molecular Sciences
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