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Yong-Ku Kim, Sang Won Jeon
BACKGROUND: Recently, neuroinflammation and the immune-kynurenine pathway have received increased attention in the psychoimmunology field of major depressive disorder (MDD), while studies related to anxiety disorders have been very limited. OBJECTIVE: This study reviewed possible mechanisms by which stress or inflammation modulate anxiety through tryptophan metabolism and the kynurenine pathway. METHOD: Relevant literature was identified through a search of MEDLINE via PubMed...
September 12, 2017: Current Neuropharmacology
Zahra Arefnasab, Abdolreza Babamahmoodi, Farhang Babamahmoodi, Ahmad Ali Noorbala, Ahmad Alipour, Yunes Panahi, Jamal Shams, Farhad Riazi Rad, Vahid Khaze, Mostafa Ghanei
Mindfulness-based Stress Reduction (MBSR) is a treatment program for relieving stress and coping with chronic illnesses. In recent three decades, studies have shown that MBSR has a positive effect on physical and psychological dimensions of chronic illnesses. Chemically pulmonary injured veterans have chronic pulmonary and psychological problems due to mustard gas exposure and complications of Iran-Iraq war. These stresses have negative effects on their general health and immune system. To the best of our knowledge, this is the first study conducted on psychoneuroimmunology and MBSR in these patients...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
Shan Qiao, Xiaoming Li, Samuele Zilioli, Zheng Chen, Huihua Deng, Juxian Pan, Weigui Guo
BACKGROUND: Existing literature suggests that endocrine measures, including the steroid hormones of cortisol and Dehydroepiandrosterone (DHEA), as well as the DHEA to cortisol ratio in the human hair can be used as promising biomarkers of chronic stress among humans. However, data are limited regarding the validity of these measures as biomarkers of chronic stress among people living with HIV (PLWH), whose endocrine system or hypothalamic pituitary adrenal (HPA) axis may be affected by HIV infection and/or antiretroviral therapy (ART) medications...
2017: PloS One
Abdolreza Babamahmoodi, Zahra Arefnasab, Ahmad Ali Noorbala, Mostafa Ghanei, Farhang Babamahmoodie, Ahmad Alipour, Mohammad Hossein Alimohammadian, Farhad Riazi Rad, Vahid Khaze, Haideh Darabi
Emotional Freedom Technique (EFT) as a new therapeutic technique in energy psychology has positive effects on psychological and physiological symptoms, and quality of life. In this research we studied the effect of this treatment on immunological factors. This study tested whether 8-week group sessions of EFT (compared to a wait-list control group) with emphasis on patient's respiratory, psychological and immunological problems in chemically pulmonary injured veterans (N=28) can affect on immunological and psychological factors...
February 2015: Iranian Journal of Allergy, Asthma, and Immunology
J E Blalock, E M Smith
In a recent commentary (Nature 309, 400; 1984) John Maddox suggested that the study of psychological effects on immunologic functions - 'psychoimmunology' - was somewhat premature. Specifically, he argued that while the concept of a link between the central nervous system and the immune system was easily accepted, there was a paucity of data of a mechanistic nature to explain the evidence that the 'mind' can control immune responses. He doubted, therefore, whether enough is known to sustain the hope that psychoimmunology was explainable...
April 1985: Immunology Today
Bartholomeus C M Haarman, Rixt F Riemersma-Van der Lek, Huibert Burger, Mina Netkova, Roosmarijn C Drexhage, Florian Bootsman, Esther Mesman, Manon Hj Hillegers, Anne T Spijker, Erik Hoencamp, Hemmo A Drexhage, Willem A Nolen
OBJECTIVES: Existing and previously published datasets were examined for associations between illness and treatment characteristics and monocyte pro-inflammatory gene expression in patients with bipolar disorder (BD). We hypothesized a priori that increased monocyte pro-inflammatory gene expression would be found more frequently in patients with a lifetime history of psychotic symptoms. METHODS: Monocyte quantitative polymerase chain reaction and symptom data from 64 patients with BD were collected from three Dutch studies...
March 2014: Bipolar Disorders
Giuseppina Messina, Paolo Lissoni, Franco Rovelli
Thanks to the discoveries of psychoneuroendocrinoimmunology, we now know that every psychological state is mediated by a specific neurochemical condition and every neurochemical change in turn influences psychological status. We can now identify three different levels of neurochemical mediation of the psychological states: neurotransmission, neuromodulation, and the psychoneuromodulation. Neurotransmission is composed of five main neural pathways, noradrenaline, acetylcholine, dopamine, serotonin, and histamine; neuromodulation; and the psychoneuromodulation...
December 2012: Current Aging Science
Sherry Anders, Midori Tanaka, Dennis K Kinney
Recent discoveries relating depression to inflammation and immune function may help to solve an important evolutionary puzzle: If depression carries with it so many negative consequences, including notable costs to survival and reproduction, then why is it common and heritable? What countervailing force or compensatory advantage has allowed susceptibility genes for depression to persist in the population at such high rates? A priori, compensatory advantages in combating infection are a promising candidate, given that infection has been the major cause of mortality throughout human history...
July 2013: Brain, Behavior, and Immunity
Robert C Bransfield
Disease progression of neuropsychiatric symptoms in Lyme/tick-borne diseases can be better understood by greater attention to psychoimmunology. Although there are multiple contributors that provoke and weaken the immune system, infections and persistent infections are significant causes of pathological immune reactions. Immune mediated ef-fects are a significant contributor to the pathophysiological processes and disease progression. These immune effects in-clude persistent inflammation with cytokine effects and molecular mimicry and both of these mechanisms may be present at the same time in persistent infections...
2012: Open Neurology Journal
Tobias Stalder, Clemens Kirschbaum
Changes to long-term secretion of the glucocorticoid cortisol are considered to play a crucial role in mediating the link between chronic stress and the development of numerous immune system related diseases. However, obtaining valid assessments of long-term cortisol levels is difficult due to limitations of previous measurement strategies in blood, saliva or urine. This review discusses evidence on a recent methodological development assumed to provide a considerable advancement in this respect: the analysis of cortisol in hair...
October 2012: Brain, Behavior, and Immunity
E Karanikas, I Giouzepas
The close interaction among factors stemming from the organic and the psychic spheres, in the formulation of the pathogenetic mechanism, underlying the initial signs and contributing to the course of a disease, is getting more obvious than ever. The theoretical background concerning participation of parameters from the psychic sphere and subsequent activation of cerebral systems-centres of stress, in the formulation of an organic basis of a disease, has been enriched with novel findings. The same happens with the study of the organic basis of psychiatric diseases...
January 2008: Psychiatrikē, Psychiatriki
Holger Steinberg, Hubertus Himmerich
Abstract Objectives. Although Kraepelin and his oeuvre have been in scientific focus over the past decades, main aspects have still been neglected. Thus the exact circumstances under which and on what topic Kraepelin wrote his habilitation thesis and qualified as university lecturer (in Germany the prerequisite to be appointed as professor) are still widely unknown. Methods. This study reconstructs his habilitation at the Medical Faculty of Leipzig University in 1882. Results. The study reveals the difficulties he had to habilitate on a topic from Wilhelm Wundt's experimental psychology and the opposition he faced from Paul Flechsig...
May 2013: World Journal of Biological Psychiatry
S C Tiwari
No abstract text is available yet for this article.
April 1994: Indian Journal of Psychiatry
Daniel L Hall, Diane Blyler, Deborah Allen, Merle H Mishel, Jamie Crandell, Barbara B Germino, Laura S Porter
BACKGROUND: Cortisol, a stress-related hormone, has been measured in many psychoimmunological studies via collection of saliva; however, patterns of participant adherence to protocol procedures are rarely described in the literature. OBJECTIVES: In this paper we examine adherence to a cortisol morning rise collection protocol and explore its associations with demographic predictors and fatigue. METHOD: Participants included 262 breast cancer survivors enrolled in a National Institute of Nursing Research funded longitudinal intervention study (5R01NR010190, M...
May 2011: Psychoneuroendocrinology
Angelo Picardi, Emanuele Tarolla, Lorenzo Tarsitani, Massimo Biondi
INTRODUCTION: People seeking for psychotherapeutic help present with a variety of conditions including stress, depression, anxiety, and maladaptive individual difference factors. This paper reviews the studies investigating the link between these conditions and immunity. FINDINGS: The relationship between stress-related conditions and immunity varies depending on the nature of the stressor. Acute time-limited stressors are associated with an upregulation of natural immunity, brief naturalistic stressors with a shift from cellular to humoral immunity, while long-term and chronic stressors with a decrease in most functional immune measures...
May 2009: Rivista di Psichiatria
S M Helfgott
An unusual pattern of hand involvement in a patient with rheumatoid arthritis (RA) is presented. There is complete sparing of a single digit, despite a severe, destructive polyarthritis involving all the other fingers. Of note, the patient began wearing a treasured family heirloom ring on the nonaffected finger approximately 1 year before the onset of her arthritis. The potential role for psychoimmunologic regulation of rheumatoid arthritis is discussed.
June 1997: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Marlies A van Duinen, Koen R J Schruers, Gunter R L Kenis, Annick Wauters, Joris Delanghe, Eric J L Griez, Michael H J Maes
OBJECTIVE: Psychoimmunological research in panic disorder (PD) so far focussed on single time point evaluation in resting conditions. No robust evidence for changes in the immune system was found using this method. However, PD is characterized by the occurrence of unexpected panic attacks (PAs). The current research focuses on cytokine and acute phase protein (APP) levels and mitogen-induced cytokine secretion following 35% CO(2) inhalation-induced panic. METHODS: Eighteen PD patients and 18 matched healthy control subjects underwent both a placebo and a 35% CO(2) inhalation on separate days...
March 2008: Journal of Psychosomatic Research
Ying-Jui Ho, Ching-Fu Wang, Wen-Yu Hsu, Ting Tseng, Cheng-Chin Hsu, Mei-Ding Kao, Yuan-Feen Tsai
BACKGROUND: Anxiety levels in rats are correlated with interleukin-2 (IL-2) levels in the brain. The aim of the present study was to investigate the effects of dioscorea (wild yam), a Chinese medicine, on emotional behavior and IL-2 levels in the brain of ovariectomized (OVX) rats. METHODS: One month after ovariectomy, female Wistar rats were screened in the elevated plus-maze (EPM) test to measure anxiety levels and divided into low anxiety (LA) and high anxiety (HA) groups, which were then given dioscorea (250, 750, or 1500 mg/kg/day) by oral gavage for 27 days and were tested in the EPM on day 23 of administration and in the forced swim test (FST) on days 24 and 25, then 3 days later, the brain was removed and IL-2 levels measured...
2007: Annals of General Psychiatry
Kun Yang, Guangrong Xie, Zhongxing Zhang, Changhong Wang, Wenbo Li, Weiqiang Zhou, Yanqing Tang
OBJECTIVE: To investigate the relationship between leptin and cytokines in depressed patients. METHODS: Thirty-three unmedicated patients (24 female, nine male) with depressive disorder and 23 healthy controls (16 female, seven male) were assessed for serum levels of interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and leptin. RESULTS: Levels of IL-6 and TNF-alpha in depressed patients were higher than in normal controls...
March 2007: Australian and New Zealand Journal of Psychiatry
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