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https://www.readbyqxmd.com/read/29863690/-comorbidity-of-epilepsy-and-chronic-disorders-in-children-and-adolescents-with-the-assessment-of-the-effectiveness-of-therapy
#1
N A Ermolenko, V P Zykov, E I Zakharova
AIM: To determine the comorbidity of epilepsy and chronic tic disorders (HTR) in children and adolescents based on the results of video-EEG monitoring and treatment efficacy. MATERIAL AND METHODS: One hundred and sixteen patients diagnosed with HTR, 83 boys and 33 girls, aged from 3 to 15 years, were studied. Clinical psychoneurological examination, psychological testing and video-EEG monitoring were performed at the first stage of the study. An effect of treatment was assessed at the second stage...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29499467/adverse-physiological-and-psychological-effects-of-screen-time-on-children-and-adolescents-literature-review-and-case-study
#2
Gadi Lissak
A growing body of literature is associating excessive and addictive use of digital media with physical, psychological, social and neurological adverse consequences. Research is focusing more on mobile devices use, and studies suggest that duration, content, after-dark-use, media type and the number of devices are key components determining screen time effects. Physical health effects: excessive screen time is associated with poor sleep and risk factors for cardiovascular diseases such as high blood pressure, obesity, low HDL cholesterol, poor stress regulation (high sympathetic arousal and cortisol dysregulation), and Insulin Resistance...
July 2018: Environmental Research
https://www.readbyqxmd.com/read/29286524/psychophysiological-characteristics-in-the-chnpp-accident-clean-up-workers-exclusion-zone-evacuees-and-anti-terrorist-operation-servicemen
#3
K M Loganovsky, M V Gresko
OBJECTIVE: Evaluation of interdependencies between psychometric parameters and spontaneous cerebral electric activity in the ChNPP accident clean up workers, evacuees from exclusion zone, and anti terrorist operation service men. OBJECT AND METHODS: Psychometric and neurophysiological parameters were reviewed in the study subjects retro spectively and in comparison. Study population included the ChNPP accident clean up workers (ACUW), evacuees from the 30 kilometer exclusion zone, specifically in a sample from a cohort of the NRCRM Clinical Epidemiological Register (n=316), and anti terrorist operation servicemen (n=81) undergoing rehabilitation in the NRCRM Radiation psychoneurology department...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29286498/psychosocial-state-of-the-adult-evacuees-and-risk-factors-of-negative-change
#4
V O Buzunov, K M Loganovsky, L I Krasnikova, M O Bomko, Yu M Belyayev, Zh S Yaroshenko, T E Domashevska
Numerous scientific studies have been carried out since the ChNPP accident indicating that the last one has caused a severe psychosocial stress in survivors. Population of radioactively contaminated territories, people migrated from the areas of strict radiation control, and accident consequences clean up participants in 1986 1987 were covered by the conducted research projects. Nature of the stress herewith is polygenic and includes factors directly related to the Chernobyl catastrophe, and factors being a result of social and economic circumstances...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29258398/pilot-study-of-metabolomics-and-psychoneurological-symptoms-in-women-with-early-stage-breast-cancer
#5
Debra E Lyon, Angela Starkweather, Yingwei Yao, Timothy Garrett, Debra Lynch Kelly, Victoria Menzies, Paweł Dereziński, Susmita Datta, Sreelakshmy Kumar, Colleen Jackson-Cook
Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses...
March 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29213042/-new-opportunities-in-the-optimization-of-epilepsy-treatment-in-adolescents
#6
V I Guzeva, I V Okhrim, O V Guzeva, V V Guzeva, N E Maksimova
In the pubertal period, the most severe forms of childhood epilepsy persist and are modified; genetically determined syndromes, atypical for early and late age periods, make their debut. Hereditary predisposition, instability of homeostatic mechanisms, neuroendocrine restructuring at the age of puberty and the influence of factors contributing to the realization of a genetic defect lead to a long-term transformation of mediator systems and formation of epileptic activity in adolescents. The authors present common approaches in the treatment and characterization of the modern antiepileptic drug perampanel, which is highly effective in treatment of patients with resistant forms of epilepsy...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29168036/the-gut-microbiome-symptoms-and-targeted-interventions-in-children-with-cancer-a-systematic-review
#7
REVIEW
Jinbing Bai, Madhusmita Behera, Deborah Watkins Bruner
PURPOSE: The gut microbiome plays a critical role in maintaining children's health and in preventing and treating children's disease. Current application of the gut microbiome in childhood cancer is still lacking. This study aimed to systematically review the following: (1) alternations in the gut microbiome throughout cancer treatment trajectories in children, (2) the associations between the gut microbiome and gastrointestinal (GI) symptoms and psychoneurological symptoms (PNS), and (3) the efficacy of therapeutic interventions in the gut microbiome in children with cancer...
February 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28972489/-psychotherapeutic-interventions-in-patients-with-auto-aggressive-behavior-during-the-first-psychotic-episode
#8
I Mudrenko, A Potapov, D Sotnikov, O Kolenko, A Kmyta
In this article the formation of psychopathological predictors auto-aggressive behavior in patients with a first psychotic episode were identified, which became "targets" in the framework of a comprehensive emergency suicide assistance to conduct the crisis psychotherapy. The work was done on the basis of the Sumy regional psychoneurologic dispensary, where 100 patients with a first psychotic episode were examined: 52 of them (core group) had suicidal symptoms and 48 (control group) had not. According to the test results of severity of auto-aggressive predictors (pre-suicidal syndrome) to clinicopsychopathological predictors of auto-aggressive behavior include: the narrowing of the cognitive function (p≤0,001), the avoidance of interpersonal contact (r≤0,001), the presence of affective (p≤0,001) and vegetative (p≤0,01) violations, the autoaggression of moderate severity (p≤0,001) and impulsivity (p≤0,001)...
September 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28945725/hematopoietic-stem-cell-transplantation-stress-psychoneurologic-symptoms-and-coping-strategies-in-adolescents-and-young-adults%C3%A2
#9
Jennifer Nance, Sheila Judge Santacroce
Psychoneurologic symptoms commonly reported by adolescents and young adults (AYAs) following hematopoetic stem cell transplantation (HSCT) include anxiety, depression, fatigue, and pain. Complementary and alternative medicine (CAM) appeals to AYAs as a means of coping with these symptoms. One example of CAM is a publicly available illness blog authored by a young adult woman undergoing HSCT. 
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October 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28944608/coexistence-of-mutations-in-keratin-10-krt10-and-the-mitochondrial-genome-in-a-patient-with-ichthyosis-with-confetti-and-leber-s-hereditary-optic-neuropathy
#10
Agnieszka Kalinska-Bienias, Agnieszka Pollak, Cezary Kowalewski, Urszula Lechowicz, Piotr Stawinski, Aleksandra Gergont, Joanna Kosinska, Ewa Pronicka, Pawel Kowalski, Katarzyna Wozniak, Rafal Ploski
Ichthyosis with confetti (IWC) is a severe congenital genodermatosis characterized by ichthyosiform erythroderma since birth and confetti-like spots of normal skin appearing in childhood as a results of revertant mosaicism. This disorder is caused by mutations in KRT10 or KRT1 genes. We report a 16-year-old boy who presented ichthyosiform erythroderma with severe desquamation since birth and gradually worsening psycho-neurological symptoms (mental retardation, ataxia, dystonia, hypoacusis). The patient conspicuously lacked typical confetti-like spots at the age of 16...
November 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28894147/intrinsic-property-of-phenylalanine-to-trigger-protein-aggregation-and-hemolysis-has-a-direct-relevance-to-phenylketonuria
#11
Bibin G Anand, Kriti Dubey, Dolat S Shekhawat, Karunakar Kar
Excess accumulation of phenylalanine is the characteristic of untreated Phenylketonuria (PKU), a well-known genetic abnormality, which triggers several neurological, physical and developmental severities. However, the fundamental mechanism behind the origin of such diverse health problems, particularly the issue of how they are related to the build-up of phenylalanine molecules in the body, is largely unknown. Here, we show cross-seeding ability of phenylalanine fibrils that can effectively initiate an aggregation process in proteins under physiological conditions, converting native protein structures to β-sheet assembly...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323624/conventional-or-natural-pharmacotherapy-and-the-prevalence-of-anxiety-and-depression-during-menopause
#12
Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28027557/pathological-personality-development-after-the-chornobyl-disaster-and-the-anti-terrorist-operation
#13
K M Loganovsky, M V Gresko
Objective of the study was to determine pathological changes of the personality of the clean up workers (liquida tors) of the Chornobyl accident and the participants in the anti terrorist operation (ATO) in Eastern Ukraine and radiation threat perception assessment.Design, object and methods. The cross sectional and retrospective assessments of the clean up workers of the Chornobyl accident (n = 185), evacuees from the Chornobyl Exclusion Zone (n = 112) from the randomized sample of individuals who are registered in the Clinical and epidemiological registry (CER) of the State Institution «National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine» [NRCRM] and partici pants of the ATO in Eastern Ukraine (n = 62) who underwent treatment and rehabilitation in the Department of Radiation Psychoneurology of the NRCRM Clinic have been done...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/27922541/effects-of-the-5-ht1a-receptor-agonists-buspirone-and-8-oh-dpat-on-pupil-size-in-common-marmosets
#14
Manato Kotani, Naoko Urushino, Itaru Natsutani, Yuji Ogi, Kazuhito Ikeda
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). Thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. Common marmosets have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field because of handling ease compared with other nonhuman primates and the requirement for small amounts of test drugs...
June 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27599815/relationships-among-psychoneurological-symptoms-and-levels-of-c-reactive-protein-over-2-years-in-women-with-early-stage-breast-cancer
#15
Angela Starkweather, Debra Lynch Kelly, Leroy Thacker, Michelle L Wright, Colleen K Jackson-Cook, Debra E Lyon
PURPOSE: The aim of the present study was to explore clusters of psychoneurological symptoms and inflammation (levels of C-reactive protein) over time in a cohort of women with early-stage breast cancer. Specifically, we examined the relationships among affective symptoms (depression, anxiety, fatigue, sleep disturbances, pain, and perceived stress), domains of cognitive performance, and levels of peripheral C-reactive over a period of 2 years. METHODS: This was a prospective, longitudinal study of 77 women diagnosed with early-stage breast cancer...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27070475/-comparative-medical-social-characteristics-of-psychiatric-outpatients
#16
D F Khritinin, M A Nekrasov
OBJECTIVE: to compare medical/social characteristics of psychiatric outpatients of rural and urban regions to optimize the activities of the regional mental health services. MATERIAL AND METHODS: Using an anonymous survey, 1042 psychiatric patients of the Orel Regional psychoneurological out-patient clinic have been examined. RESULTS AND CONCLUSION: Significant differences in the access to professional psychiatric and psychotherapeutic care between rural and urban populations of the region were shown...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/26803493/sk3-channel-overexpression-in-mice-causes-hippocampal-shrinkage-associated-with-cognitive-impairments
#17
Sabine Martin, Marcio Lazzarini, Christian Dullin, Saju Balakrishnan, Felipe V Gomes, Milena Ninkovic, Ahmed El Hady, Luis A Pardo, Walter Stühmer, Elaine Del-Bel
The dysfunction of the small-conductance calcium-activated K+ channel SK3 has been described as one of the factors responsible for the progress of psychoneurological diseases, but the molecular basis of this is largely unknown. This report reveals through use of immunohistochemistry and computational tomography that long-term increased expression of the SK3 small-conductance calcium-activated potassium channel (SK3-T/T) in mice induces a notable bilateral reduction of the hippocampal area (more than 50 %)...
March 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/26675887/the-dopamine-d1-receptor-agonist-skf-82958-effectively-increases-eye-blinking-count-in-common-marmosets
#18
Manato Kotani, Akihiko Kiyoshi, Takeshi Murai, Tomokazu Nakako, Kenji Matsumoto, Atsushi Matsumoto, Masaru Ikejiri, Yuji Ogi, Kazuhito Ikeda
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson's disease and Tourette syndrome [1,2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field due to their more developed prefrontal cortex than rodents, easy handling compare to other non-human primates, and requirement for small amounts of test drugs...
March 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26635957/swallowed-dentures-two-cases-and-a-review
#19
REVIEW
Mahir Gachabayov, Mubariz Isaev, Lala Orujova, Emin Isaev, Evgeniy Yaskin, Dmitriy Neronov
INTRODUCTION: Denture ingestion or aspiration is a problem requiring awareness of different specialists including dentists, surgeons, otolaryngologists, anesthesiologists etc. in terms of prevention, early diagnosis and adequate treatment. Complications of swallowed dentures include hollow viscus necrosis, perforation, penetration to neighbor organs leading to fistulae, bleeding and obstruction. PRESENTATION OF CASES: First case is a 54-year-old female who accidentally swallowed retractable one-tooth denture during fall about 22 h before admission and clinical manifestation of acute small bowel obstruction developed...
December 2015: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/26563119/intrathecal-ziconotide-and-morphine-for-pain-relief-a-case-series-of-eight-patients-with-refractory-cancer-pain-including-five-cases-of-neuropathic-pain
#20
Ana Bella de la Calle Gil, Isaac Peña Vergara, María Auxiliadora Cormane Bornacelly, Antonio Pajuelo Gallego
INTRODUCTION: Studies have shown that, at low doses and with careful titration, combination therapy with intrathecal ziconotide and morphine results in rapid control of opioid-refractory cancer pain. However, there is a lack of published data regarding the efficacy and safety of intrathecal ziconotide specifically for the treatment of neuropathic cancer pain. CASE SERIES: Case reports of ziconotide intrathecal infusion in eight patients (age 45-71 years; 75% male) with chronic, uncontrolled cancer pain during therapy with intrathecal morphine plus bupivacaine were reviewed...
December 2015: Neurology and Therapy
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