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Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
K M Loganovsky, M V Gresko
Objective of the study was to determine pathological changes of the personality of the clean up workers (liquida tors) of the Chornobyl accident and the participants in the anti terrorist operation (ATO) in Eastern Ukraine and radiation threat perception assessment.Design, object and methods. The cross sectional and retrospective assessments of the clean up workers of the Chornobyl accident (n = 185), evacuees from the Chornobyl Exclusion Zone (n = 112) from the randomized sample of individuals who are registered in the Clinical and epidemiological registry (CER) of the State Institution «National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine» [NRCRM] and partici pants of the ATO in Eastern Ukraine (n = 62) who underwent treatment and rehabilitation in the Department of Radiation Psychoneurology of the NRCRM Clinic have been done...
December 2016: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
Manato Kotani, Naoko Urushino, Itaru Natsutani, Yuji Ogi, Kazuhito Ikeda
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents (mydriasis) and humans (miosis). Thus, it is important to establish a quantitative system for measuring pupil size using other species, such as nonhuman primates. Common marmosets have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field because of handling ease compared with other nonhuman primates and the requirement for small amounts of test drugs...
June 2017: Behavioural Pharmacology
Angela Starkweather, Debra Lynch Kelly, Leroy Thacker, Michelle L Wright, Colleen K Jackson-Cook, Debra E Lyon
PURPOSE: The aim of the present study was to explore clusters of psychoneurological symptoms and inflammation (levels of C-reactive protein) over time in a cohort of women with early-stage breast cancer. Specifically, we examined the relationships among affective symptoms (depression, anxiety, fatigue, sleep disturbances, pain, and perceived stress), domains of cognitive performance, and levels of peripheral C-reactive over a period of 2 years. METHODS: This was a prospective, longitudinal study of 77 women diagnosed with early-stage breast cancer...
January 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
D F Khritinin, M A Nekrasov
OBJECTIVE: to compare medical/social characteristics of psychiatric outpatients of rural and urban regions to optimize the activities of the regional mental health services. MATERIAL AND METHODS: Using an anonymous survey, 1042 psychiatric patients of the Orel Regional psychoneurological out-patient clinic have been examined. RESULTS AND CONCLUSION: Significant differences in the access to professional psychiatric and psychotherapeutic care between rural and urban populations of the region were shown...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Sabine Martin, Marcio Lazzarini, Christian Dullin, Saju Balakrishnan, Felipe V Gomes, Milena Ninkovic, Ahmed El Hady, Luis A Pardo, Walter Stühmer, Elaine Del-Bel
The dysfunction of the small-conductance calcium-activated K(+) channel SK3 has been described as one of the factors responsible for the progress of psychoneurological diseases, but the molecular basis of this is largely unknown. This report reveals through use of immunohistochemistry and computational tomography that long-term increased expression of the SK3 small-conductance calcium-activated potassium channel (SK3-T/T) in mice induces a notable bilateral reduction of the hippocampal area (more than 50 %)...
March 2017: Molecular Neurobiology
Manato Kotani, Akihiko Kiyoshi, Takeshi Murai, Tomokazu Nakako, Kenji Matsumoto, Atsushi Matsumoto, Masaru Ikejiri, Yuji Ogi, Kazuhito Ikeda
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson's disease and Tourette syndrome [1,2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field due to their more developed prefrontal cortex than rodents, easy handling compare to other non-human primates, and requirement for small amounts of test drugs...
March 1, 2016: Behavioural Brain Research
Mahir Gachabayov, Mubariz Isaev, Lala Orujova, Emin Isaev, Evgeniy Yaskin, Dmitriy Neronov
INTRODUCTION: Denture ingestion or aspiration is a problem requiring awareness of different specialists including dentists, surgeons, otolaryngologists, anesthesiologists etc. in terms of prevention, early diagnosis and adequate treatment. Complications of swallowed dentures include hollow viscus necrosis, perforation, penetration to neighbor organs leading to fistulae, bleeding and obstruction. PRESENTATION OF CASES: First case is a 54-year-old female who accidentally swallowed retractable one-tooth denture during fall about 22 h before admission and clinical manifestation of acute small bowel obstruction developed...
December 2015: Annals of Medicine and Surgery
Ana Bella de la Calle Gil, Isaac Peña Vergara, María Auxiliadora Cormane Bornacelly, Antonio Pajuelo Gallego
INTRODUCTION: Studies have shown that, at low doses and with careful titration, combination therapy with intrathecal ziconotide and morphine results in rapid control of opioid-refractory cancer pain. However, there is a lack of published data regarding the efficacy and safety of intrathecal ziconotide specifically for the treatment of neuropathic cancer pain. CASE SERIES: Case reports of ziconotide intrathecal infusion in eight patients (age 45-71 years; 75% male) with chronic, uncontrolled cancer pain during therapy with intrathecal morphine plus bupivacaine were reviewed...
December 2015: Neurology and Therapy
Irina A Rubleva, Leonid S Persin, Anna B Slabkovskaya, Nikolay N Zavadenko, Andrea Deregibus, Cesare L Debernardi
Non-nutritive sucking behaviors such as finger- and tongue-sucking, tongue thrust, lips- or cheek-sucking, nail-, lip- or tongue-biting and other pressure habits represent risk factors for malocclusion. The association between psycho-neurological disorders and different types of malocclusion in children with sucking habits was long studied. During neurological examination, many children with sucking habits are diagnosed as Minimal Cerebral Dysfunction or Attention Deficit Hyperactivity Disorder (ADHD) bearers...
2015: International Journal of Orthodontics
N V Gonchar, A N Suvorov, V P Maryshev, T M Sorokina, T V Churkova, S M Kharit
Aim of this study was to investigate the efficacy of prophylactic use of a liquid probiotic form based on Enterococcus faecium L3 in children first year of life to increase resistance to acute respiratory infections (ARI) in the winter-spring period and improve nutritional status. In a specialized (psychoneurologic) orphanage of St. Petersburg within three months of winter-spring period in 2014 observed 29 children in the first year of life. Observed children were randomly divided into two groups. The main group (n = 14) within three months received daily per os liquid probiotic form based on E...
2015: Experimental & Clinical Gastroenterology
Jolanta Skowroń, Sławomir Czerczak
The working environment is the special case of the non-natural environment created by man in which the increased production activity brings about the concentration of stimulators particularly aggressive to the human organism, such as chemical hazards, noise, vibration, extreme temperatures, and finally, intensified psychological and emotional stress. Depending on the nature and intensity, working environment factors have been classified into dangerous, harmful and annoying. The workers are more and more frequently exposed to dangerous chemicals in the working environment...
2015: International Journal of Occupational Medicine and Environmental Health
Noran Aboalela, Debra Lyon, R K Elswick, Debra Lynch Kelly, Jenni Brumelle, Harry D Bear, Colleen Jackson-Cook
While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that compromise their quality of life. The biological basis for these persistent symptoms is unclear, but could reflect the acquisition of soma-wide chromosomal instability following the multiple biological/psychological exposures associated with the diagnosis/treatment of breast cancer...
2015: PloS One
Debra Lynch Kelly, Debra E Lyon, Saunjoo L Yoon, Ann L Horgas
BACKGROUND: Approximately 1.6 million Americans were diagnosed with cancer in 2014. To combat their disease, many individuals received either curative or palliative treatments that produced undesired symptoms. These symptoms, which often cause significant distress for individuals coping with cancer, may share biologic underpinnings such as epigenetic changes and immune dysregulation. Alterations in the normal flora of the gut may also influence cancer symptoms. OBJECTIVE: The aim of this review is to describe the emerging role for the gut microbiome in cancer research, especially the potential relationship between the gut microbiome and cancer symptoms...
May 2016: Cancer Nursing
Qing Zhou, Colleen Jackson-Cook, Debra Lyon, Robert Perera, Kellie J Archer
Breast cancer (BC) is the second most common cancer among women. Research shows many women with BC experience anxiety, depression, and stress (ADS). Epigenetics has recently emerged as a potential mechanism for the development of depression.1 Although there are growing numbers of research studies indicating that epigenetic changes are associated with ADS, there is currently no evidence that this association is present in women with BC. The goal of this study was to identify high-throughput methylation sites (CpG sites) that are associated with three psychoneurological symptoms (ADS) in women with BC...
2015: Cancer Informatics
L A Zakharova
We analyzed data from our studies and other author's works concerning the influence of stress stimuli on the development of neuroendocrine and immune systems. The results of our analysis suggest that "immunological stress" induced by viral or bacterial infection, an unhealthy diet, and the mother's behavior during pregnancy and lactation are significant risk factors for the developing offspring. The brain is the key target for these factors. The continuous effect of stress stimuli during critical periods of brain development induces hyperactivity and increased response of hypothalamic-pituitary-adrenal system...
January 2015: Izvestiia Akademii Nauk. Seriia Biologicheskaia
M V Novoselova, Iu G Samoĭlova, O S Tonkikh
OBJECTIVE: To assess the role of brain magnetic resonance imaging (MRI) in patients with type 1 diabetes mellitus (DMI) in relation to clinical, metabolic, and psychoneurological disorders. MATERIAL AND METHODS: Fifty-eight patients aged 16 to 30 years with DM1 were examined; a control group consisted of 29 healthy young people matched by gender and age. Their examination involved clinical, metabolic, and psychological testing. The quality of life was assessed using the general Medical Outcomes Study Short Form (MOS SF-36) and the specific Audit-Dependent Quality of Life (AdDQoL)...
May 2014: Vestnik Rentgenologii i Radiologii
A V Shurlygina, E V Mel'nikova, I L Kovalenko, A G Galiamina, O B Gritsyk, M V Tenditnik, V A Trufakin, N N Kudriavtseva
It has been shown that psychoneurological disorders are accompanied by different disturbances of immunity. Paper aimed to study the effects of repeated experience of aggression in daily agonistic interactions leading to the development of behavioral psychopathology on the parameters of cellular immunity in the thymus and spleen. There were no found the changes in the weight indexes, the number of cells in the thymus, spleen and blood in aggressive mice. In the spleen of aggressive mice percent of B-lymphocytes--CD19+ and CD16/32+, as well as T-lymphocytes CD4+8-, CD4-8+, and CD4+25(hi) decreased and percent of CD4-25+ increased in comparison with the controls...
November 2014: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
L D Firsova
THE PURPOSE OF THE STUDY: To evaluate the degree of adherence to treatment in comparison with the psychological reactions to the disease in patients with chronic diseases of the digestive system. MATERIAL AND METHODS: We examined 106 patients with chronic diseases of the upper gastrointestinal tract. Psychological reactions to the disease were studied using personality questionnaires of the Bekhterev Institute (the St. Petersburg V.M. Bekhterev Psychoneurological Research Institute), adherence to treatment--using a specially designed questionnaire...
2013: Experimental & Clinical Gastroenterology
Angela R Starkweather, Debra E Lyon, R K Elswick, Alison J Montpetit, Yvette Conley, Nancy L McCain
Personalized medicine applies knowledge about the patient's individual characteristics in relation to health and intervention outcomes, including treatment response and adverse side-effects, to develop a tailored treatment plan. For women with breast cancer, personalized medicine has substantially improved the rate of survival, however, a high proportion of these women report multiple, co-occurring psychoneurological symptoms over the treatment trajectory that adversely affect their quality of life. In a subset of these women, co-occurring symptoms referred to as symptoms clusters, can persist long after treatment has ended...
September 2013: Current Pharmacogenomics and Personalized Medicine
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