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https://www.readbyqxmd.com/read/29793039/antimicrobial-resistance-in-the-context-of-the-syrian-conflict-drivers-before-and-after-the-onset-of-conflict-and-key-recommendations
#1
REVIEW
Aula Abbara, Timothy M Rawson, Nabil Karah, Wael El-Amin, James Hatcher, Bachir Tajaldin, Osman Dar, Omar Dewachi, Ghassan Abu Sitta, Bernt Eric Uhlin, Annie Sparrow
Current evidence describing antimicrobial resistance (AMR) in the context of the Syrian conflict is of poor quality and sparse in nature. In this paper we explore and report the major drivers of AMR that were present in Syria pre-conflict and those that have emerged since its onset in March 2011. Drivers which existed before the conflict included a lack of enforcement of existing legislation to regulate over the counter antibiotics and notification of communicable diseases. This contributed to a number of drivers of AMR after the onset of conflict which were also compounded by the exodus of trained staff, the increase in overcrowding and unsanitary conditions, the increase in injuries and economic sanctions limiting the availability of required laboratory medical materials and equipment...
May 21, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29792175/pulse-actinomycin-d-as-first-line-treatment-of-low-risk-post-molar-non-choriocarcinoma-gestational-trophoblastic-neoplasia
#2
Lei Li, Xirun Wan, Fengzhi Feng, Tong Ren, Junjun Yang, Jun Zhao, Fang Jiang, Yang Xiang
BACKGROUND: Little data exists predicting the resistance to actinomycin D (Act-D) single-agent for gestational trophoblastic neoplasia (GTN). The objective was to determine the overall success of pulse Act-D and the factors predictive of resistance to pulse Act-D in the treatment of low-risk, non-choriocarcinoma post-molar GTN. METHODS: From January 2013 to October 2016, according to the FIGO criteria for the diagnosis of post-molar disease and the FIGO risk-factor scoring system for GTN, a total of 135 patients with post-molar non-choriocarcinoma GTN who were chemotherapy-naive with a FIGO score < 7 were treated with single-agent pulse Act-D as a first-line regimen, in Peking Union Medical College Hospital...
May 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29792074/lessons-learned-conducting-a-multi-center-trial-with-a-military-population-the-tinnitus-retraining-therapy-trial
#3
Roberta W Scherer, Leonora D Sensinger, Benigno Sierra-Irizarry, Craig Formby
Background The Tinnitus Retraining Therapy Trial (TRTT), a randomized, placebo-controlled, multi-center trial, evaluated the efficacy of tinnitus retraining therapy and its individual components, tinnitus-specific educational counseling and sound therapy versus the standard of care, in military practice to improve study participants' quality of life. The trial was conducted at six US military hospitals to take advantage of the greater prevalence of tinnitus in the military population. Methods During the trial, various challenges arose that were uniquely related to the military setting...
May 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29792056/placenta-in-intrauterine-fetal-demise-iufd-a-comprehensive-study-from-a-tertiary-care-hospital
#4
Anisha Manocha, Gayatri Ravikumar, Julian Crasta
BACKGROUND: Intrauterine fetal demise (IUFD) is an unpredictable and challenging obstetric complication. Its etiology is multifactorial with more than 60% attributed to the placental cause. The present study was done with a primary objective of understanding the placental lesions underlying IUFD. METHODS: In this retrospective observational study, IUFD cases (> 22 weeks) between January 2012-September 2015 were collected from pathology database. The clinical details with ultrasound findings were collected from mother's charts...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29791695/current-strategies-to-prevent-iatrogenic-ureteral-injury-during-colorectal-surgery
#5
Jonathan Douissard, Frederic Ris, Philippe Morel, Nicolas Christian Buchs
Iatrogenic ureteral injuries are a source of major concern among surgeons performing colorectal procedures. Although they are uncommon, these lesions lead to severe morbidity and long-term functional disabilities, as well as an increase in mortality, hospital stay, and cost. The laparoscopic approach has gained popularity in the field of colorectal surgery and is associated with improved global postoperative outcomes. However, it is also considered to increase the risk of ureteral injury when compared to open surgery, especially during left colonic and rectal resections...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791476/identifying-county-characteristics-associated-with-resident-well-being-a-population-based-study
#6
Brita Roy, Carley Riley, Jeph Herrin, Erica S Spatz, Anita Arora, Kenneth P Kell, John Welsh, Elizabeth Y Rula, Harlan M Krumholz
BACKGROUND: Well-being is a positively-framed, holistic assessment of health and quality of life that is associated with longevity and better health outcomes. We aimed to identify county attributes that are independently associated with a comprehensive, multi-dimensional assessment of individual well-being. METHODS: We performed a cross-sectional study examining associations between 77 pre-specified county attributes and a multi-dimensional assessment of individual US residents' well-being, captured by the Gallup-Sharecare Well-Being Index...
2018: PloS One
https://www.readbyqxmd.com/read/29790991/understanding-delays-in-acute-stroke-care-a-systematic-review-of-reviews
#7
Yacine Lachkhem, Stéphane Rican, Étienne Minvielle
Background: Stroke is the leading cause of adult long-term disability in Western countries. Intravenous thrombolytic therapy with recombinant tissue plasminogen activator is safe and effective within the first 4.5 h after the onset of stroke. Various factors delaying acute stroke care have been identified in the literature. This review aimed to provide an overview of factors delaying acute stroke care and attempted to show how they interact in a synthetic framework. Methods: We conducted a systematic review of literature reviews published in Medline and DORIS until 2016 on factors influencing acute stroke pathway timeframe...
June 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29790481/antiviral-combination-therapy-for-cytomegalovirus-infection-in-high-risk-infants
#8
Surabhi B Vora, Adam W Brothers, Alpana Waghmare, Janet A Englund
BACKGROUND: Cytomegalovirus (CMV) infection is a major risk factor for mortality in infants with severe combined immunodeficiency (SCID) and other profound immune defects. Specific antiviral therapy must be initiated early and aggressively because of the potential for antiviral resistance, rapid dissemination and poor transplant outcomes. Combination antiviral therapy is routinely administered for some viral infections, but the value of this approach for the treatment of CMV is unclear...
May 23, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29790466/association-of-anger-expression-out-with-nk-cell-counts-in-colorectal-cancer-patients
#9
Estela Kakoo-Brioso, Luís Costa, Sílvia Ouakinin
INTRODUCTION: There is growing evidence describing the relation between psychological factors and the progression of colorectal cancer. Several mechanisms have been proposed but the one showing more promising evidence relies on the modulation of the antitumoral immune response by psychological factors, particularly through natural killer cells. We aimed to study the relation between natural killer cell count and anxiety, depression and anger state, trait and expression in 54 pre-surgical colorectal cancer patients...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29790323/-prevalence-and-risk-factors-of-overweight-and-obesity-after-liver-transplantation-retrospective-study-at-three-years-after-transplantation
#10
Sara Di Cosmo, Maura Lusignani, Matteo Manini, Roberto Accardi
BACKGROUND AND AIM: Weight gain is frequently observed among liver transplanted patients. This condition is often associated to the development of other post LT morbidities which might influence the long-term post-transplant survival. However, the risk factors asso- ciated have not yet been identified. The aim of this study was to assess the prevalence of over- weight and obesity, to notice Body Mass Index changes and associated risk factors, within three years after LT. METHODS: All the patients consecutively transplanted at the Liver Transplantation Unit of Fondazione IRCCS "Cà-Granda Ospedale Maggiore Policlinico", Milan between January 2005 and June 2014 were retrospectively evaluated for inclusion...
January 2018: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29790148/prospective-pilot-study-of-cerebral-near-infrared-spectroscopy-monitoring-during-pre-hospital-anaesthesia
#11
S Ångerman, S Länkimäki, N Neuvonen, H Kirves, J Nurmi
BACKROUND: Near-infrared spectroscopy (NIRS) provides a non-invasive measure of cerebral tissue oxygenation. The literature on application of this method in pre-hospital setting is limited. The aims of this study were to determine the feasibility of cerebral NIRS during pre-hospital anaesthesia and to quantify the changes in front lobe regional oxygen saturation (rSO2 ) during the pre-hospital phase. METHODS: NIRS monitoring (Nonin SenSmart X-100) of front lobe regional oxygen saturation (rSO2) was initiated before induction of anaesthesia in 31 adult patients and continued until hospital arrival...
May 22, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29789905/pre-operative-mri-staging-of-endometrial-cancer-in-a-multicentre-cancer-network-can-we-match-single-centre-study-results
#12
N D Soneji, N Bharwani, A Ferri, V Stewart, A Rockall
OBJECTIVES: To evaluate the staging accuracy of magnetic resonance imaging (MRI) for endometrial cancer in daily practice over a 3-year period at a tertiary referral centre receiving scans from a large number of hospitals with varying protocols. To compare these daily practice results to published data from single-centre studies. METHODS: After ethical approval, MRI staging records for 270 studies from nine network and three centre hospitals were retrospectively collected and compared with final operative histopathology...
May 22, 2018: European Radiology
https://www.readbyqxmd.com/read/29789237/predictors-of-biochemical-recurrence-after-radical-prostatectomy-in-an-afro-caribbean-population-in-guadeloupe-french-west-indies
#13
L Brureau, E Emeville, L Multigner, P Blanchet
PURPOSE: Few studies have investigated predictive risk factors of biochemical recurrence (BCR) after radical prostatectomy (RP) in other than Caucasian and Asian populations. We aimed to identify pre- and post-operative predictors of BCR after RP in an Afro-Caribbean population in Guadeloupe (French West Indies). PATIENTS AND METHODS: The study included 964 patients who underwent RP for clinically localized prostate cancer between April 1, 2000 and December 31, 2010 in the University Hospital of Guadeloupe...
May 20, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29789006/outcomes-of-lung-transplantation-in-adults-with-bronchiectasis
#14
Jodie Birch, Syba S Sunny, Katy L M Hester, Gareth Parry, F Kate Gould, John H Dark, Stephen C Clark, Gerard Meachery, James Lordan, Andrew J Fisher, Paul A Corris, Anthony De Soyza
BACKGROUND: Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transplantation for Br are reported here. METHODS: A retrospective review of case notes and transplantation databases was conducted for patients that had underwent lung transplantation for bronchiectasis at the Freeman Hospital between 1990 and 2013. RESULTS: Fourty two BR patients underwent lung transplantation, the majority (39) having bilateral sequential lung transplantation...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788927/chronic-kirschsteiniothelia-infection-superimposed-on-a-pre-existing-non-infectious-bursitis-of-the-ankle-the-first-case-report-of-human-infection
#15
Masanori Nishi, Ichiro Okano, Takatoshi Sawada, Yasuka Hara, Kiwamu Nakamura, Katsunori Inagaki, Takashi Yaguchi
BACKGROUND: Kirschsteiniothelia is a saprophytic fungus that is abundantly present in the environment. To date, there have been no reports of human infection caused by this fungus. We report a case of Kirschsteiniothelia infection superimposed on a pre-existing non-infectious bursitis of the ankle. CASE PRESENTATION: An 81-year-old immunocompetent female local farmer noticed the presence of a nodule on her right ankle 5 years before her first visit to our hospital...
May 22, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29788917/parental-reported-allergic-disorders-and-emergency-department-presentations-for-allergy-in-the-first-five-years-of-life-a-longitudinal-birth-cohort
#16
Gerben Keijzers, Amy Sweeny, Julia Crilly, Norm Good, Cate M Cameron, Gabor Mihala, Rani Scott, Paul A Scuffham
BACKGROUND: To measure rates of parental-report of allergic disorders and ED presentations for allergic disorders in children, and to describe factors associated with either. METHODS: An existing cohort of 3404 children born between 2006 and 2011 (Environments for Healthy Living) with prospectively collected pre-natal, perinatal and follow-up data were linked to i) nationwide Medicare and pharmaceutical data and ii) Emergency Department (ED) data from four hospitals in Australia...
May 22, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29788203/do-cost-containment-policies-save-money-and-influence-physicians-prescribing-behavior-lessons-from-south-korea-s-drug-policy-for-diabetes-medication
#17
Shin-On Kang, Seung Ju Kim, Sohee Park, Sung-In Jang, Eun-Cheol Park
Objective: We evaluate the effects of drug price reduction policy on pharmaceutical expenditure and prescription patterns in diabetes medication. Design: An interrupted time series study design using generalized estimating equations. Setting: This study used National Health Insurance claim data from 2010 to 2013. Participants: A total of 68 127 diabetes patients and 12 465 hospitals. Intervention(s): The drug price reduction policy...
May 17, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29788037/mycoplasma-pneumoniae-among-children-hospitalized-with-community-acquired-pneumonia
#18
Preeta K Kutty, Seema Jain, Thomas H Taylor, Anna M Bramley, Maureen H Diaz, Krow Ampofo, Sandra R Arnold, Derek J Williams, Kathryn M Edwards, Jonathan A McCullers, Andrew T Pavia, Jonas M Winchell, Stephanie J Schrag, Lauri A Hicks
Background: The burden and epidemiology of Mycoplasma pneumoniae (Mp) among U.S. children (<18 years) hospitalized with community-acquired pneumonia (CAP) are poorly understood. Methods: In the Etiology of Pneumonia in the Community (EPIC) study, we prospectively enrolled 2254 children hospitalized with radiographically-confirmed pneumonia from January 2010-June 2012 and tested nasopharyngeal/oropharyngeal swabs for Mp using real-time polymerase chain reaction (PCR)...
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29788003/robotic-parathyroid-surgery-current-perspectives-and-future-considerations
#19
Asit Arora, George Garas, Neil Tolley
Robotic parathyroidectomy represents a novel surgical approach in the treatment of primary hyperparathyroidism when the parathyroid adenoma has been pre-operatively localised. It represents the "fourth generation" in the evolution of parathyroid surgery following a process of surgical evolution from cervicotomy and 4-gland exploration to a variety of minimally invasive, open and endoscopic, targeted approaches. The existing evidence (levels 2-3) supports it as a feasible and safe technique with equivalent results to targeted open parathyroidectomy for primary hyperparathyroidism in carefully selected patients...
May 22, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29787555/implementation-of-a-ct-scan-practice-guideline-for-pediatric-trauma-patients-reduces-unnecessary-scans-without-impacting-outcomes
#20
Patrick R McGrew, Paul J Chestovich, Jay D Fisher, Deborah A Kuhls, Douglas R Fraser, Purvi P Patel, Chad W Katona, Syed Saquib, John J Fildes
INTRODUCTION: Computed Tomography (CT) scans are useful in the evaluation of trauma patients, but are costly and pose risks from ionizing radiation in children. Recent literature has demonstrated the utility of CT scan guidelines in the management of pediatric trauma. This study objective is to review our treatment of pediatric blunt trauma patients and evaluate CT utilization before and after CT-guideline implementation. METHODS: Our Pediatric Level 2 Trauma Center (TC) implemented a CT scan practice guideline for pediatric trauma patients in March 2014...
May 4, 2018: Journal of Trauma and Acute Care Surgery
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