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adipokine and immune

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https://www.readbyqxmd.com/read/28791026/decrease-of-markers-related-to-bone-erosion-in-serum-of-patients-with-musculoskeletal-disorders-after-serial-low-dose-radon-spa-therapy
#1
Aljona Cucu, Kateryna Shreder, Daniela Kraft, Paul Friedrich Rühle, Gerhart Klein, Gerhard Thiel, Benjamin Frey, Udo S Gaipl, Claudia Fournier
Musculoskeletal disorders (MSDs) are the most frequent cause of disability in Europe. Reduced mobility and quality of life of the patients are often associated with pain due to chronic inflammation. The inflammatory process, accompanied by a destruction of the cartilage and bone tissue, is discussed as a result of (A) the infiltration of immune cells into the joints, (B) an altered homeostasis of the joint cavity (synovium) with a critical role of bone remodeling cells, and (C) release of inflammatory factors including adipokines in the arthritic joint...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28771382/relationship-of-circulating-chemerin-and-omentin-levels-with-th17-and-th9-cell-immune-responses-in-patients-with-asthma
#2
Qing Zhou, Yu Fu, Liangan Hu, Qian Li, Meng Jin, E Jiang
OBJECTIVE: Adipokines are correlated with immune response in asthma, but data on the roles of chemerin and omentin in asthmaare limited. This studyexplored the relationship of chemerin and omentin levels with Th17 and Th9 cells in asthma. METHODS: Seventy-six asthmatics were divided into the intermittent to mild persistent (n = 28), moderate persistent (n = 26) and severe persistent (n = 22) and enrolled in the study. Additionally, 20 healthy subjects were enrolled as controls...
August 3, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28762474/adipokines-psoriasis-systemic-inflammation-and-endothelial-dysfunction
#3
REVIEW
Maeve Lynch, Tomas Ahern, Cheryl M Sweeney, Anna Malara, Anne-Marie Tobin, Donal O'Shea, Brian Kirby
Adipokines are secreted by white adipose tissue, an active endocrine organ, and play a role in the regulation of metabolic functions such as lipid metabolism, inflammation, and vascular homeostasis. Adipokines are secreted in excess in obesity and contribute to the development of associated comorbidities such as metabolic syndrome and atherosclerosis. Psoriasis, a chronic immune-mediated skin disease, is associated with obesity and increased cardiovascular risk. Understanding the role of adipokines in psoriasis may in part explain the association between psoriasis and cardiovascular disease...
August 1, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28718060/innate-immune-responses-and-osteoarthritis
#4
REVIEW
Evangelia Kalaitzoglou, Timothy M Griffin, Mary Beth Humphrey
PURPOSE OF THE REVIEW: Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory responses that contribute to OA progression and are the focus of this review. RECENT FINDINGS: Recent studies have identified risk factors for OA progression including increased innate immune responses secondary to aging-associated myeloid skewing, obesity-related myeloid activation, and synovial tissue hyperplasia with activated macrophage infiltration...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28708082/pathogenic-role-of-il-17-producing-immune-cells-in-obesity-and-related-inflammatory-diseases
#5
REVIEW
Marwa Chehimi, Hubert Vidal, Assia Eljaafari
Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in obese individuals are the former site of progressive infiltration by pro-inflammatory immune cells, which together with increased inflammatory adipokine secretion induce adipocyte insulin resistance. IL-17-producing T (Th17) cells are part of obese AT infiltrating cells, and are likely to be promoted by adipose tissue-derived mesenchymal stem cells, as previously reported by our team. Whereas Th17 cell are physiologically implicated in the neutralization of fungal and bacterial pathogens through activation of neutrophils, they may also play a pivotal role in the onset and/or progression of chronic inflammatory diseases, or cancer, in which obesity is recognized as a risk factor...
July 14, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28707000/inducing-maternal-inflammation-promotes-leptin-production-in-offspring-but-does-not-improve-allergic-symptoms-in-a-mouse-model-of-allergic-rhinitis
#6
Atsuko Imai, Keiko Satoi, Eka Fujimoto, Kazuto Sato
AIMS: The intrauterine environment is considered to affect immunological development in fetus, leading to an increased risk of developing allergy. In particular, maternal lipopolysaccharides (LPS) administration might regulate the development of allergic disease in offspring. Several studies have shown that being obese relates to a higher prevalence of allergic diseases compared to normal weight. The present study explored the effects of inducing maternal inflammation with LPS before pregnancy on body weight, physical composition including body fat, adipokine production, and pathology of allergic rhinitis in offspring...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28697011/association-between-adipokines-and-critical-illness-outcomes
#7
Tahar Hajri, Mohamed Gharib, Sanjeev Kaul, Martin S Karpeh
BACKGROUND: Adipose tissue is an endocrine organ that plays a critical role in immunity and metabolism by virtue of a large number of hormones and cytokines, collectively termed adipokines. Dysregulation of adipokines has been linked to the pathogenesis of multiple diseases, but some questions have arisen concerning the value of adipokines in critical illness setting. The objective of this review was to evaluate the associations between blood adipokines and critical illness outcomes. METHODS: PubMed, CINAHL, Scopus and the Cochrane Library databases were searched from inception through July 2016 without language restriction...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28672736/innate-immunity-orchestrates-adipose-tissue-homeostasis
#8
Yi-Wei Lin, Li-Na Wei
Obesity is strongly associated with multiple diseases including insulin resistance, type 2 diabetes, cardiovascular diseases, fatty liver disease, neurodegenerative diseases and cancers, etc. Adipose tissue (AT), mainly brown AT (BAT) and white AT (WAT), is an important metabolic and endocrine organ that maintains whole-body homeostasis. BAT contributes to non-shivering thermogenesis in a cold environment; WAT stores energy and produces adipokines that fine-tune metabolic and inflammatory responses. Obesity is often characterized by over-expansion and inflammation of WAT where inflammatory cells/mediators are abundant, especially pro-inflammatory (M1) macrophages, resulting in chronic low-grade inflammation and leading to insulin resistance and metabolic complications...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28649760/immunometabolism-of-human-autoimmune-diseases-from-metabolites-to-extracellular-vesicles
#9
REVIEW
Paola de Candia, Veronica De Rosa, Vincenzo Gigantino, Gerardo Botti, Antonio Ceriello, Giuseppe Matarese
Immunometabolism focuses on the mechanisms regulating the impact of metabolism on lymphocyte activity and autoimmunity outbreak. The adipose tissue is long known to release adipokines, either pro- or anti-inflammatory factors bridging nutrition and immune function. More recently, adipocytes were discovered to also release extracellular vesicles (EVs) containing a plethora of biological molecules, including metabolites and microRNAs, which can regulate cell function/metabolism in distant tissues, suggesting that immune regulatory function by the adipose tissue may be far more complex than originally thought...
June 26, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28640444/impact-of-growth-hormone-on-regulation-of-adipose-tissue
#10
Katie M Troike, Brooke E Henry, Elizabeth A Jensen, Jonathan A Young, Edward O List, John J Kopchick, Darlene E Berryman
Increasing prevalence of obesity and obesity-related conditions worldwide has necessitated a more thorough understanding of adipose tissue (AT) and expanded the scope of research in this field. AT is now understood to be far more complex and dynamic than previously thought, which has also fueled research to reevaluate how hormones, such as growth hormone (GH), alter the tissue. In this review, we will introduce properties of AT important for understanding how GH alters the tissue, such as anatomical location of depots and adipokine output...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28619369/mechanisms-of-atherosclerosis-and-cardiovascular-disease-in-antiphospholipid-syndrome-and-systemic-lupus-erythematosus-new-therapeutic-approaches
#11
REVIEW
Chary Lopez-Pedrera, M Ángeles Aguirre-Zamorano, Carlos Pérez-Sánchez
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are 2 highly related autoimmune-rheumatic diseases associated with an increased risk of developing cardiovascular (CV) diseases. Despite the great progresses made in understanding the pathological mechanisms leading to CV diseases in those pathologies, there is still the unmet need to improve long term prognosis. CV diseases in SLE and APS is thought to happen as the result of a complex interaction between traditional CV risk factors, immune deregulation and disease activity, including the synergic effect of cytokines, chemokines, adipokines, proteases, autoantibodies, adhesion receptors, oxidative stress and a plethora of intracellular signalling molecules...
June 12, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28616851/effect-of-aerobic-interval-training-on-serum-il-10-tnf%C3%AE-and-adipokines-levels-in-women-with-multiple-sclerosis-possible-relations-with-fatigue-and-quality-of-life
#12
Motahare Mokhtarzade, Rouholah Ranjbar, Nastaran Majdinasab, Darpan Patel, Mehdieh Molanouri Shamsi
PURPOSE: Multiple sclerosis is associated with immune system dysfunction and chronic inflammation; however, possible relations between immunologic and metabolic factors and some psychological indexes such as fatigue and quality of life, especially in relation to exercise training, have not yet been investigated. The present study was designed to investigate the effect of aerobic interval training on interleukin-10/tumor necrosis factor ratio and adipokine (leptin and adiponectin) concentrations in women with multiple sclerosis...
August 2017: Endocrine
https://www.readbyqxmd.com/read/28614774/new-insight-into-the-direct-anti-inflammatory-activity-of-a-myokine-irisin-against-proinflammatory-activation-of-adipocytes-implication-for-exercise-in-obesity
#13
A I Mazur-Bialy, J Bilski, E Pochec, T Brzozowski
A biological activity of myokine irisin, has been intensively investigated in the context of a browning process occurring in white adipose tissue, but its role as a modulator of immune response has been little studied. The aim of our study was to determine the impact of irisin (0 - 100 nM) on pro-inflammatory activation of adipocyte 3T3 L1 cell line. Irisin reduced in a concentration-dependent manner the expression and activity of major proinflammatory cytokines, e.g. tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) expression and their secretion into cell medium...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28592510/methodological-utility-of-chemerin-as-a-novel-biomarker-of-immunity-and-metabolism
#14
Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing, Krasimira Aleksandrova
Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses...
July 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28587339/orf3-as-a-sensitive-and-specific-diagnostic-index-for-hepatitis-e
#15
Lijuan Li, Min Liu, Chengrui Geng, Yunmei Zou, Tong Jiao
We explored the significance of the expression of hepatitis E virus (HEV) open reading frame 3 (ORF3) in hepatitis E rat models. We also investigated its diagnostic value. Forty Sprague-Dawley (SD) rats were infected with HEV and 10 uninfected rats were selected for the control group. Rats were sacrificed at 14, 21, 35 and 70 days after infection. They were divided into 4 groups: Model group 1, model group 2, model group 3 and model group 4. ORF3 protein expression level in liver tissue, level of adipokines [fatty acid synthase (FAS), tissue inhibitor of metalloproteinase-2 (TIMP-2) and angiotensin-converting enzyme inhibitor 2 (ACE-2)], Th1/Th2 cells balance [interferon (IFN), interleukin-4 (IL-4) and Th1/Th2] and the level of immune outcome (levels of CD4(+), CD8(+) T lymphocytes and CD4(+)/CD8(+)) were measured and compared among groups...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28565874/resistin-increases-the-expression-of-nod2-in-mouse-monocytes
#16
Yi Ren, Taomei Wan, Zhicai Zuo, Hengmin Cui, Xi Peng, Jing Fang, Junliang Deng, Yanchun Hu, Shuming Yu, Liuhong Shen, Xiaoping Ma, Ya Wang, Zhihua Ren
Previous studies have indicated that resistin, a type of adipokine, contributes to the development of insulin resistance and type 2 diabetes mellitus, and mediates inflammatory reactions. However, a specific receptor for resistin has not yet been identified. In this study, the relationship between resistin and nucleotide-binding oligomerization domain-like receptors, as well as resistin signal transduction, was examined through transfection, quantitative polymerase chain reaction, western blot analysis and ELISA...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28536758/serum-levels-of-adipokines-in-patients-with-idiopathic-inflammatory-myopathies-a-pilot-study
#17
Javier Loaiza-Félix, Mariana Moreno-Ramírez, F Luis Pérez-García, Valentín Jiménez-Rojas, Fausto Sánchez-Muñoz, M Luis Amezcua-Guerra
Adipokines are cytokines not only regulating metabolic and endocrine activities, but also modulating inflammatory and immune responses in several clinical settings, including autoimmunity. This study was aimed to evaluate whether serum adipokine levels may be useful as markers of disease activity in patients with idiopathic inflammatory myopathies (IIM). Adiponectin, leptin, chemokine C-C motif ligand-2 (CCL2), interleukin (IL)-6, and tumor necrosis factor (TNF) were measured in the serum of all participants...
August 2017: Rheumatology International
https://www.readbyqxmd.com/read/28536316/-adipose-stem-cell-system
#18
Yumiko Oishi, Ichiro Manabe
Adipose tissues are the major organ that controls systemic energy metabolism and maintain homeostasis by storing lipids, dissipating them as heat, and producing various adipokines. There are two major classes of adipocytes: white and brown adipocytes. White adipocytes store and release lipids, while brown adipocytes burn substrates to produce heat. In addition to classical brown adipose tissues consisting of brown adipocytes, cold exposure and β3 stimulation induce development of brown cell-like "beige" adipocytes in white adipose tissues...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28513775/adiponectin-inhibits-oxidization-induced-differentiation-of-t-helper-cells-through-inhibiting-costimulatory-cd40-and-cd80
#19
Y Xiao, T Deng, Z Shang, D Wang
Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxidized low density lipoprotein cholesterol-treated endothelial cells were assayed by real time PCR and immunofluorescence...
May 15, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28490813/leptin-receptor-antagonism-of-inkt-cell-function-a-novel-strategy-to-combat-multiple-myeloma
#20
M Favreau, E Menu, D Gaublomme, K Vanderkerken, S Faict, K Maes, E De Bruyne, S Govindarajan, M Drennan, S Van Calenbergh, X Leleu, L Zabeau, J Tavernier, K Venken, D Elewaut
A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as master regulator of anti-myeloma tumor immunity by modulating the invariant natural killer T (iNKT) cell function. A marked increase in serum leptin levels and leptin receptor (LR) expression on iNKT cells in MM patients and the 5T33 murine MM model was observed. MM cells and leptin synergistically counteracted anti-tumor functionality of both murine and human iNKT cells...
May 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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