keyword
MENU ▼
Read by QxMD icon Read
search

hypothalamus and adipokine

keyword
https://www.readbyqxmd.com/read/27845741/cst-an-herbal-formula-exerts-anti-obesity-effects-through-brain-gut-adipose-tissue-axis-modulation-in-high-fat-diet-fed-mice
#1
AbuZar Ansari, Shambhunath Bose, Mukesh Kumar Yadav, Jing-Hua Wang, Yun-Kyung Song, Seong-Gyu Ko, Hojun Kim
The brain, gut, and adipose tissue interact to control metabolic pathways, and impairment in the brain-gut-adipose axis can lead to metabolic disorders, including obesity. Chowiseungcheng-tang (CST), a herbal formulation, is frequently used to treat metabolic disorders. Here, we investigated the anti-obesity effect of CST and its link with brain-gut-adipose axis using C57BL/6J mice as a model. The animals were provided with a normal research diet (NRD) or high-fat diet (HFD) in absence or presence of CST or orlistat (ORL) for 12 weeks...
November 11, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27003399/adipokines-in-healthy-skeletal-muscle-and-metabolic-disease
#2
REVIEW
C A Coles
Adipose tissue not only functions as a reserve to store energy but has become of major interest as an endocrine organ, releasing signalling molecules termed adipokines which impact on other tissues, such as skeletal muscle. Adipocytes, within skeletal muscle and adipose tissue, secrete adipokines to finely maintain the balance between feed intake and energy expenditure. This book chapter focuses on the three adipokines, adiponectin, leptin and IL-6, which have potent effects on skeletal muscle during rest and exercise...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26870797/mimecan-a-hormone-abundantly-expressed-in-adipose-tissue-reduced-food-intake-independently-of-leptin-signaling
#3
Huang-Ming Cao, Xiao-Ping Ye, Jun-Hua Ma, He Jiang, Sheng-Xian Li, Rong-Ying Li, Xue-Song Li, Cui-Cui Guo, Zhi-Quan Wang, Ming Zhan, Chun-Lin Zuo, Chun-Ming Pan, Shuang-Xia Zhao, Cui-Xia Zheng, Huai-Dong Song
Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice...
November 2015: EBioMedicine
https://www.readbyqxmd.com/read/26646203/photoperiodic-and-diurnal-regulation-of-wnt-signaling-in-the-arcuate-nucleus-of-the-female-djungarian-hamster-phodopus-sungorus
#4
Alisa Boucsein, Jonas Benzler, Cindy Hempp, Sigrid Stöhr, Gisela Helfer, Alexander Tups
The WNT pathway was shown to play an important role in the adult central nervous system. We previously identified the WNT pathway as a novel integration site of the adipokine leptin in mediating its neuroendocrine control of metabolism in obese mice. Here we investigated the implication of WNT signaling in seasonal body weight regulation exhibited by the Djungarian hamster (Phodopus sungorus), a seasonal mammal that exhibits profound annual changes in leptin sensitivity. We furthermore investigated whether crucial components of the WNT pathway are regulated in a diurnal manner...
February 2016: Endocrinology
https://www.readbyqxmd.com/read/26574894/adipokines-in-human-reproduction
#5
REVIEW
Joëlle Dupont, Xavier Pollet-Villard, Maxime Reverchon, Namya Mellouk, Rachel Levy
Adipose tissue communicates with other central and peripheral organs by the synthesis and release of substances called adipokines. The most studied adipokine is leptin but others have been recently identified including resistin, adiponectin, chemerin, omentin and visfatin. These adipokines have a critical role in the development of obesity-related complications and inflammatory conditions. However, they are also involved in other functions in the organism including reproductive functions. Indeed, many groups have demonstrated that adipokine receptors, such as adiponectin and chemerin, but also adipokines themselves (adiponectin, chemerin, resistin, visfatin and omentin) are expressed in human peripheral reproductive tissues and that these adipokines are likely to exert direct effects on these tissues...
October 2015: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/26282459/dual-action-of-leptin-on-rest-firing-and-stimulated-catecholamine-release-via-phosphoinositide-3-kinase-driven-bk-channel-up-regulation-in-mouse-chromaffin-cells
#6
Daniela Gavello, David Vandael, Sara Gosso, Emilio Carbone, Valentina Carabelli
KEY POINTS: Leptin is an adipokine produced by the adipose tissue regulating body weight through its appetite-suppressing effect and, as such, exerts a relevant action on the adipo-adrenal axis. Leptin has a dual action on adrenal mouse chromaffin cells both at rest and during stimulation. At rest, the adipokine inhibits the spontaneous firing of most cells by enhancing the probability of BK channel opening through the phosphoinositide 3-kinase signalling cascade. This inhibitory effect is absent in db(-) /db(-) mice deprived of Ob receptors...
November 15, 2015: Journal of Physiology
https://www.readbyqxmd.com/read/26236282/age-associated-weight-gain-leptin-and-sirt1-a-possible-role-for-hypothalamic-sirt1-in-the-prevention-of-weight-gain-and-aging-through-modulation-of-leptin-sensitivity
#7
REVIEW
Tsutomu Sasaki
The hypothalamus is the principal regulator of body weight and energy balance. It modulates both energy intake and energy expenditure by sensing the energy status of the body through neural inputs from the periphery as well as direct humoral inputs. Leptin, an adipokine, is one of the humoral factors responsible for alerting the hypothalamus that enough energy is stored in the periphery. Plasma leptin levels are positively linked to adiposity; leptin suppress energy intake and stimulates energy expenditure...
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/25759638/impact-of-hypothalamic-reactive-oxygen-species-in-the-regulation-of-energy-metabolism-and-food-intake
#8
REVIEW
Anne Drougard, Audren Fournel, Philippe Valet, Claude Knauf
Hypothalamus is a key area involved in the control of metabolism and food intake via the integrations of numerous signals (hormones, neurotransmitters, metabolites) from various origins. These factors modify hypothalamic neurons activity and generate adequate molecular and behavioral responses to control energy balance. In this complex integrative system, a new concept has been developed in recent years, that includes reactive oxygen species (ROS) as a critical player in energy balance. ROS are known to act in many signaling pathways in different peripheral organs, but also in hypothalamus where they regulate food intake and metabolism by acting on different types of neurons, including proopiomelanocortin (POMC) and agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/25534851/paraventricular-nucb2-nesfatin-1-is-directly-targeted-by-leptin-and-mediates-its-anorexigenic-effect
#9
Gantulga Darambazar, Masanori Nakata, Takashi Okada, Lei Wang, EnXu Li, Atsumi Shinozaki, Megumi Motoshima, Masatomo Mori, Toshihiko Yada
An adipokine leptin plays a central role in the regulation of feeding and energy homeostasis via acting on the hypothalamus. However, its downstream neuronal mechanism is not thoroughly understood. The neurons expressing nucleobindin-2 (NUCB2)-derived nesfatin-1 in the hypothalamic paraventricular nucleus (PVN) have been implicated in feeding and energy homeostasis. The present study aimed to explore the role of PVN NUCB2/nesfatin-1 in the leptin action, by using adeno-associated virus (AAV) vectors encoding shRNA targeting NUCB2 (AAV-NUCB2-shRNA)...
January 24, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25268283/effects-of-adrenalectomy-on-daily-gene-expression-rhythms-in-the-rat-suprachiasmatic-and-paraventricular-hypothalamic-nuclei-and-in-white-adipose-tissue
#10
Yan Su, Rianne van der Spek, Ewout Foppen, Joan Kwakkel, Eric Fliers, Andries Kalsbeek
It is assumed that in mammals the circadian rhythms of peripheral clocks are synchronized to the environment via neural, humoral and/or behavioral outputs of the central pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN). With regard to the humoral outputs, the daily rhythm of the adrenal hormone corticosterone is considered as an important candidate. To examine whether adrenal hormones are necessary for the maintenance of daily rhythms in gene expression in white adipose tissue (WAT), we used RT-PCR to check rhythmic as well as 24 h mean gene expression in WAT from adrenalectomized (ADX) and sham-operated rats...
March 2015: Chronobiology International
https://www.readbyqxmd.com/read/24882411/long-term-high-soybean-oil-feeding-alters-regulation-of-body-temperature-in-rats
#11
Hiromi Tsushima, Kazuyo Yamada, Daisuke Miyazawa, Mayumi Mori, Yoko Hashimoto, Takeshi Ohkubo, Hidehiko Hibino, Harumi Okuyama
We investigated whether body temperature (BT) regulatory mechanisms are influenced by dietary fatty acids (FA). Male Wistar rats were fed a high-fat diet containing fish oil (HFD), soybean oil (HSD) or lard (HLD). At the 20-week intervention, the BT of the HSD and HLD groups were lower than that of the normal diet (ND) group in the light and dark periods. The intracerebroventricular injections of interleukin-1β and bombesin in the HSD group induced greater hyperthermia and weaker hypothermia, respectively, than in the ND group...
2014: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/24780611/central-adiponectin-administration-reveals-new-regulatory-mechanisms-of-bone-metabolism-in-mice
#12
COMPARATIVE STUDY
Yuwei Wu, Qisheng Tu, Paloma Valverde, Jin Zhang, Dana Murray, Lily Q Dong, Jessica Cheng, Hua Jiang, Maribel Rios, Elise Morgan, Zhihui Tang, Jake Chen
Adiponectin (APN), the most abundant adipocyte-secreted adipokine, regulates energy homeostasis and exerts well-characterized insulin-sensitizing properties. The peripheral or central effects of APN regulating bone metabolism are beginning to be explored but are still not clearly understood. In the present study, we found that APN-knockout (APN-KO) mice fed a normal diet exhibited decreased trabecular structure and mineralization and increased bone marrow adiposity compared with wild-type (WT) mice. APN intracerebroventricular infusions decreased uncoupling protein 1 (UCP1) expression in brown adipose tissue, epinephrine and norepinephrine serum levels, and osteoclast numbers, whereas osteoblast osteogenic marker expression and trabecular bone mass increased in APN-KO and WT mice...
June 15, 2014: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24741039/leptin-modulates-the-intrinsic-excitability-of-agrp-npy-neurons-in-the-arcuate-nucleus-of-the-hypothalamus
#13
Scott B Baver, Kevin Hope, Shannon Guyot, Christian Bjørbaek, Catherine Kaczorowski, Kristen M S O'Connell
The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine leptin inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) neuronal activity, resulting in decreased food intake. Here we show that diet-induced obesity in mice is associated with persistent activation of NPY neurons and a failure of leptin to reduce the firing rate or hyperpolarize the resting membrane potential. However, the molecular mechanism whereby diet uncouples leptin's effect on neuronal excitability remains to be fully elucidated...
April 16, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/24596169/nesfatin-1-increases-energy-expenditure-and-reduces-food-intake-in-rats
#14
Kerstin Wernecke, Ingolf Lamprecht, Olaf Jöhren, Hendrik Lehnert, Carla Schulz
OBJECTIVE: Energy homeostasis results from a balance of food intake and energy expenditure, accomplished by the interaction of peripheral and central nervous signals. The recently discovered adipokine nesfatin-1 is involved in the central control of food intake, but whether it also participates in the regulation of thermogenesis is unknown. METHODS: Nesfatin-1 was administered intracerebroventricularly to freely moving, male Wistar rats and direct calorimetry was performed to assess its effects on thermogenesis...
July 2014: Obesity
https://www.readbyqxmd.com/read/24518677/temporal-changes-in-nutritional-state-affect-hypothalamic-pomc-peptide-levels-independently-of-leptin-in-adult-male-mice
#15
Aaron J Mercer, Ronald C Stuart, Courtney A Attard, Veronica Otero-Corchon, Eduardo A Nillni, Malcolm J Low
Hypothalamic proopiomelanocortin (POMC) neurons constitute a critical anorexigenic node in the central nervous system (CNS) for maintaining energy balance. These neurons directly affect energy expenditure and feeding behavior by releasing bioactive neuropeptides but are also subject to signals directly related to nutritional state such as the adipokine leptin. To further investigate the interaction of diet and leptin on hypothalamic POMC peptide levels, we exposed 8- to 10-wk-old male POMC-Discosoma red fluorescent protein (DsRed) transgenic reporter mice to either 24-48 h (acute) or 2 wk (chronic) food restriction, high-fat diet (HFD), or leptin treatment...
April 15, 2014: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24475720/-er-stress-and-cardiometabolic-disease-role-of-adipokines
#16
Song-Yang Zhang, Juan Feng, Xian Wang
ER stress is defined as an imbalance between protein synthesis and protein folding capacity, resulting in the accumulation of misfolded or unfolded protein in ER. Temperate ER stress through UPR enhances the folding capacity of ER and restores the ER homeostasis, exerting a cell protection role. While prolonged ER stress lead to inflammation, cell dysfunction and apoptosis, which takes part in the progression of insulin resistance and atherosclerosis. In the condition of obesity or hyperhomocysteinemia, ER stress in adipose tissue, hypothalamus, liver and other tissue or organs causes the dysregulation of adipokines secretion as well as abnormal receptor or post-receptor signal transduction, which plays an significant role in cardiometabolic disease...
October 2013: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
https://www.readbyqxmd.com/read/24428531/palmitoylethanolamide-prevents-metabolic-alterations-and-restores-leptin-sensitivity-in-ovariectomized-rats
#17
G Mattace Raso, A Santoro, R Russo, R Simeoli, O Paciello, C Di Carlo, S Diano, A Calignano, Rosaria Meli
It has been suggested a role of fatty acid ethanolamides in control of feeding behavior. Among these, palmitoylethanolamide (PEA) has not been directly implicated in appetite regulation and weight gain. The aim of this study was to investigate the effect of PEA on food intake and body weight and the interaction between PEA and hypothalamic leptin signaling in ovariectomized rats. Ovariectomy produced hyperphagia and increased weight gain, making it an useful model of mild obesity. Ovariectomized rats were treated with PEA (30 mg/kg sc) for 5 weeks...
April 2014: Endocrinology
https://www.readbyqxmd.com/read/24406511/orange-spotted-grouper-epinephelus-coioides-adiponectin-receptors-molecular-characterization-mrna-expression-and-subcellular-location
#18
Chaobin Qin, Bin Wang, Caiyun Sun, Jirong Jia, Wensheng Li
Adiponectin is an abundantly secreted adipokine from adipose tissue in mammals, which plays important roles in the regulation of glucose and lipid metabolism. The biological function of adiponectin is mediated by at least two receptors (AdipoR1 and AdipoR2). Although both of them were identified in mammals, there are few researches about adiponectin and its receptors in teleosts. In this study, two types of adiponectin receptors have been isolated and characterized in the orange-spotted grouper (Epinephelus coioides)...
March 1, 2014: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/24269538/peripheral-chemerin-administration-modulates-hypothalamic-control-of-feeding
#19
Luigi Brunetti, Giustino Orlando, Claudio Ferrante, Lucia Recinella, Sheila Leone, Annalisa Chiavaroli, Chiara Di Nisio, Rugia Shohreh, Fabio Manippa, Adriana Ricciuti, Michele Vacca
Chemerin is a recently identified adipokine that is involved in the regulation of adipogenesis, energy metabolism, and inflammation. The aim of the present study was to investigate the role of chemerin on food intake, body weight and hypothalamic peptidergic and aminergic modulators which play a pivotal role in feeding regulation in rats. Male adult Wistar rats were intraperitoneally injected, daily for 17 days at 9.00am, with either vehicle (saline; N=12) or chemerin (8μg/kg; N=12) and (16μg/kg; N=12). Food intake was recorded 24h after each administration...
January 2014: Peptides
https://www.readbyqxmd.com/read/24166765/hormones-and-diet-but-not-body-weight-control-hypothalamic-microglial-activity
#20
Yuanqing Gao, Nickki Ottaway, Sonja C Schriever, Beata Legutko, Cristina García-Cáceres, Esther de la Fuente, Clarita Mergen, Susanne Bour, Joshua P Thaler, Randy J Seeley, Jessica Filosa, Javier E Stern, Diego Perez-Tilve, Michael W Schwartz, Matthias H Tschöp, Chun-Xia Yi
The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic feedback and regulating energy homeostasis. Recent studies revealed activation of microglia in mice with high-fat diet (HFD)-induced obesity (DIO), suggesting a potential pathophysiological role for inflammatory processes within the hypothalamus. To further investigate the metabolic causes and molecular underpinnings of such glial activation, we analyzed the microglial activity in wild-type (WT), monogenic obese ob/ob (leptin deficient), db/db (leptin-receptor mutation), and Type-4 melanocortin receptor knockout (MC4R KO) mice on either a HFD or on standardized chow (SC) diet...
January 2014: Glia
keyword
keyword
34489
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"