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https://www.readbyqxmd.com/read/27920099/systematic-regional-lymph-node-dissection-for-upper-tract-urothelial-carcinoma-improves-patient-survival
#1
Hiroshi Furuse, Yuto Matsushita, Takashi Yajima, Taiki Kato, Takahisa Suzuki, Rikiya Matsumoto, Daisuke Motoyama, Takayuki Sugiyama, Atsushi Otsuka, Seiichiro Ozono
OBJECTIVE: Unlike for bladder cancer, the impact of regional lymph node dissection for upper tract urothelial carcinoma is unclear. We explored whether patient survival was influenced by systematic regional lymph node dissection, using resection templates according to the main tumor location, during radical nephroureterectomy for upper tract urothelial carcinoma. METHODS: The systematic regional lymph node dissection group was defined as cases in which the dissection of nodes and surrounding tissues followed the established template, and the non-systematic regional lymph node dissection group as cases undergoing limited or no lymph node dissection...
December 4, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27904104/the-effects-of-unilateral-nephrectomy-on-blood-pressure-and-its-circadian-rhythm
#2
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Daisuke Motoyama, Takayuki Sugiyama, Masao Nagata, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda
Objective Hypertension and diurnal blood pressure (BP) variation are widely accepted as risk factors for renal damage. However, the effects of unilateral nephrectomy on BP and its circadian rhythm have not yet been clarified in patients with a compromised renal function, including dialysis patients. Methods We investigated 22 unilateral nephrectomized patients (16 men and 6 women, age: 64.5±14.3 years). The function of the circulating renin-angiotensin system (RAS) (plasma renin activity and plasma angiotensin II) and 24-h ambulatory BP monitoring (ABPM) were evaluated before and after nephrectomy...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27888102/the-phosphatidyl-inositol-3-kinase-pathway-does-not-suppress-activation-of-the-arf-and-bim-genes-by-deregulated-e2f1-activity
#3
Kenta Kurayoshi, Junko Okuno, Eiko Ozono, Ritsuko Iwanaga, Andrew P Bradford, Kazuyuki Kugawa, Keigo Araki, Kiyoshi Ohtani
The transcription factor E2F plays crucial roles in tumor suppression by activating pro-apoptotic genes such as the tumor suppressor ARF. The regulation of the ARF gene is distinct from that of growth-related E2F targets, in that it is specifically activated by deregulated E2F activity, induced by over-expression of E2F or forced inactivation of pRB, but not by physiological E2F activity induced by growth stimulation. The phosphatidyl inositol 3 kinase (PI3K) pathway was reported to suppress expression of some atypical pro-apoptotic genes by over-expressed E2F1...
November 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27882481/assessment-criteria-for-vitamin-d-deficiency-insufficiency-in-japan-proposal-by-an-expert-panel-supported-by-the-research-program-of-intractable-diseases-ministry-of-health-labour-and-welfare-japan-the-japanese-society-for-bone-and-mineral-research-and-the
#4
Ryo Okazaki, Keiichi Ozono, Seiji Fukumoto, Daisuke Inoue, Mika Yamauchi, Masanori Minagawa, Toshimi Michigami, Yasuhiro Takeuchi, Toshio Matsumoto, Toshitsugu Sugimoto
Vitamin D is indispensable for the maintenance of bone and mineral health. Inadequate vitamin D action increases the risk for various musculoskeletal/mineral events including fracture, fall, secondary hyperparathyroidism, diminished response to antiresorptives, rickets/osteomalacia, and hypocalcemia. Its most common cause in recent years is vitamin D deficiency/insufficiency, clinically defined by a low serum 25-hydroxyvitamin D [25(OH)D] level. Guidelines for vitamin D insufficiency/deficiency defined by serum 25(OH)D concentrations have been published all over the world...
November 23, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27823720/impact-of-sleep-on-osteoporosis-sleep-quality-is-associated-with-bone-stiffness-index
#5
Nobuo Sasaki, Saeko Fujiwara, Hidehisa Yamashita, Ryoji Ozono, Kazushi Teramen, Yasuki Kihara
OBJECTIVE: The aim of the present study was to investigate the impact of sleep on osteoporosis. METHODS: The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total of 1032 participants (25-85 years of age) who underwent health examinations were included. Sleep habits, including its timing (bed time), quantity (time in bed [TIB]), and quality, were assessed using the Pittsburgh Sleep Quality Index (PSQI)...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27780981/longitudinal-observation-of-serum-anti-m%C3%A3-llerian-hormone-in-three-girls-after-cancer-treatment
#6
Yoko Miyoshi, Kie Yasuda, Makiko Tachibana, Hisao Yoshida, Emiko Miyashita, Takako Miyamura, Yoshiko Hashii, Kae Hashimoto, Tadashi Kimura, Keiichi Ozono
Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acute and chronic effects of cancer therapy on the ovary. Three young female patients with different hematological diseases were registered, and their medical records were reviewed...
October 2016: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/27762664/limited-immunogenicity-of-human-ips-cell-derived-cartilages
#7
Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki
Articular cartilage damage does not spontaneously heal and could ultimately result in a loss of joint function. Damaged cartilage can be repaired with cell/tissue sources that are transplanted, however, autologous chondrocytes are limited in number as a cell source. Induced pluripotent stem cells (iPSCs) are a relatively new and abundant cell source and can be made from the patient, but at considerable cost. Because cartilage is immunoprivileged tissue, allogeneic cartilages have been transplanted effectively without matching for human leukocyte antigen (HLA), but are difficult to acquire due to scarcity of donors...
October 20, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27761002/intrarenal-renin-angiotensin-system-activity-is-augmented-after-initiation-of-dialysis
#8
Naro Ohashi, Shinsuke Isobe, Sayaka Ishigaki, Takahisa Suzuki, Masafumi Ono, Tomoyuki Fujikura, Takayuki Tsuji, Akihiko Kato, Seiichiro Ozono, Hideo Yasuda
Circulating renin-angiotensin system (RAS) activation is maintained after renal function has deteriorated. The activation of the intrarenal RAS plays a critical role in the pathophysiology of chronic kidney disease (CKD), independently of the circulating RAS. However, the activation of intrarenal RAS and the chymase-dependent pathway after initiation of dialysis has not been clarified. We recruited 19 CKD patients (10 without dialysis and 9 with dialysis) who underwent a heminephrectomy. Circulating RAS was investigated before nephrectomy...
October 20, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27748053/hepatocellular-carcinoma-in-children-and-young-patients-with-chronic-hbv-infection-and-the-usefulness-of-alpha-fetoprotein-assessment
#9
Hitoshi Tajiri, Tomoko Takano, Hideo Tanaka, Kosuke Ushijima, Ayano Inui, Yoko Miyoshi, Keiichi Ozono, Daiki Abukawa, Takeshi Endo, Stephen Brooks, Yasuhito Tanaka
The aims of the study were to elucidate the clinical characteristics of patients who developed hepatocellular carcinoma (HCC) related to persistent HBV infection since childhood and to investigate usefulness of assessing alpha-fetoprotein (AFP) in this population. A nationwide multicenter survey of children with chronic HBV infection was performed. Among 548 patients, 15 patients developed HCC at the median age of 15 years (range 9-36), including 13 males and 2 females. A case-control comparison showed that HBeAg seroconversion and liver cirrhosis were associated with the occurrence of HCC...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27739425/glucocorticoid-regulation-of-atp-release-from-spinal-astrocytes-underlies-diurnal-exacerbation-of-neuropathic-mechanical-allodynia
#10
Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W Salter, Kazuhide Inoue, Shigehiro Ohdo
Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in glucocorticoids from the adrenal glands. Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn...
October 14, 2016: Nature Communications
https://www.readbyqxmd.com/read/27729603/-internal-carotid-artery-stenosis-associated-with-hyoid-bone-can-hyoid-bone-be-a-risk-factor-for-acute-cerebrovascular-syndrome
#11
Ichiro Kawahara, Keisuke Ozono, Takashi Fujimoto, Makoto Hirose
Eagle syndrome is a well-known disease caused by elongation of the styloid process and/or calcification of the stylohyoid ligament, which interferes with adjacent anatomical structures, giving rise to acute cerebrovascular syndrome(ACVS)and/or pain. Although hyoid bone is also a stylohyoid complex, its association with ACVS is not well known. Thus, we investigated the anatomical relationship between the internal carotid artery(ICA)and the hyoid bone. Between January 2014 and December 2015, three-dimensional computed tomographic angiography(3D-CTA)of the neck was performed for 218 patients...
October 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27725446/cyp2a13-genetic-polymorphisms-in-relation-to-the-risk-of-bladder-cancer-in-japanese-smokers
#12
Masaki Kumondai, Hiroki Hosono, Kazuhiko Orikasa, Yoichi Arai, Tomio Arai, Haruhiko Sugimura, Seiichiro Ozono, Takayuki Sugiyama, Tatsuya Takayama, Takamitsu Sasaki, Noriyasu Hirasawa, Masahiro Hiratsuka
Tobacco-specific nitrosamines including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), which can be activated by the metabolic enzyme CYP2A13, are potent procarcinogens. Smoking plays a role in carcinogenesis in the human bladder, which expresses CYP2A13 at a relatively high level. Numerous genetic polymorphisms of CYP2A13 causing amino acid substitution might reduce CYP2A13 metabolic activity toward NNK and NNN, resulting in decreased susceptibility to bladder cancer. The aim of this study was to reveal any association between bladder cancer development and CYP2A13 genetic polymorphisms in Japanese smokers...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27705979/functional-expression-of-an-osmosensitive-cation-channel-transient-receptor-potential-vanilloid-4-in-rat-vestibular-ganglia
#13
Takefumi Kamakura, Makoto Kondo, Yoshihisa Koyama, Yukiko Hanada, Yusuke Ishida, Yukiko Nakamura, Takahiro Yamada, Yasumitsu Takimoto, Tadashi Kitahara, Yoshiyuki Ozono, Arata Horii, Takao Imai, Hidenori Inohara, Shoichi Shimada
Transient receptor potential vanilloid (TRPV) 4 is a nonselective cation channel expressed in sensory neurons such as those in the dorsal root and trigeminal ganglia, kidney, and inner ear. TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-phorbol 12,13-didecanoate (4α-PDD). We investigated the expression of TRPV4 in rat vestibular ganglion (VG) neurons. The TRPV4 gene was successfully amplified from VG neuron mRNA using reverse-transcription polymerase chain reaction...
October 6, 2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/27689065/asia-prostate-cancer-study-a-cap-study-launch-symposium
#14
Hideyuki Akaza, Yoshihiko Hirao, Choung-Soo Kim, Mototsugu Oya, Seiichiro Ozono, Dingwei Ye, Matthew Cooperberg, Shiro Hinotsu, Ji Youl Lee, Gang Zhu, Mikio Namiki, Shigeo Horie, Byung Ha Chung, Chung-Hsin Chen, Ng Chi Fai, Lukman Hakim, Edmund Chiong, Jason Letran, Rainy Umbas, Kazuhiro Suzuki, Kazuo Nishimura, Teng Aik Ong, Bannakij Lojanapiwat, Tong-Lin Wu, Wun-Jae Kim, Declan Murphy, Osamu Ogawa, Peter Carroll, Seiji Naito, Taiji Tsukamoto
The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27686226/comparison-of-mirabegron-and-imidafenacin-for-efficacy-and-safety-in-japanese-female-patients-with-overactive-bladder-a-randomized-controlled-trial-comfort-study
#15
Atsushi Otsuka, Shinji Kageyama, Takahisa Suzuki, Rikiya Matsumoto, Hiroshi Nagae, Motoaki Kitagawa, Hiroshi Furuse, Seiichiro Ozono
OBJECTIVES: To evaluate the efficacy and safety of mirabegron compared with imidafenacin for the treatment of female patients with overactive bladder. METHODS: Patients (n = 89) were randomized to receive 0.1 mg imidafenacin twice daily (n = 47) or 50 mg mirabegron once daily (n = 42) for 12 weeks. The primary efficacy end-point was change in total Overactive Bladder Symptom Score. Secondary efficacy end-points included change in Overactive Bladder Symptom Score, 3-day micturition diary, International Prostate Symptom Score and Overactive Bladder Questionnaire...
December 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27639037/extracellular-phosphate-induces-the-expression-of-dentin-matrix-protein-1-through-the-fgf-receptor-in-osteoblasts
#16
Jin Nishino, Miwa Yamazaki, Masanobu Kawai, Kanako Tachikawa, Keiko Yamamoto, Kazuaki Miyagawa, Mikihiko Kogo, Keiichi Ozono, Toshimi Michigami
Dentin matrix protein 1 (DMP1) is an extracellular matrix protein involved in phosphate metabolism and biomineralization, and its expression markedly increases during the maturation of osteoblasts into osteocytes. We previously reported that an increased level of inorganic phosphate (Pi) in media up-regulated the expression of Dmp1 in primary osteocytes isolated from mouse bones. In the present study, we found that elevated extracellular Pi strongly induced the expression of Dmp1 in osteoblasts and explored its underlying mechanism of action...
September 17, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27601194/critical-diamond-blackfan-anemia-due-to-ribosomal-protein-s19-missense-mutation
#17
Shuichi Ozono, Miho Mitsuo, Maiko Noguchi, Shin-Ichiro Nakagawa, Koichiro Ueda, Hiroko Inada, Shouichi Ohga, Etsuro Ito
Diamond-Blackfan anemia (DBA) is a rare congenital disorder characterized by pure erythrocyte aplasia, and approximately 70% of patients carry mutations in the genes encoding ribosomal proteins (RP). Here, we report the case of a male infant with DBA who presented with anemic crisis (hemoglobin [Hb] concentration 1.5 g/dL) at 58 days after birth. On admission, the infant was pale and had tachypnea, but recovered with intensive care, including red blood cell transfusions, and prednisolone. Based on the clinical diagnosis of DBA, the father of the infant had cyclosporine-A-dependent anemia...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27572087/key-predictive-factors-for-efficacy-of-axitinib-in-first-line-metastatic-renal-cell-carcinoma-subgroup-analysis-in-japanese-patients-from-a-randomized-double-blind-phase-ii-study
#18
Yoshihiko Tomita, Satoshi Fukasawa, Mototsugu Oya, Hirotsugu Uemura, Nobuo Shinohara, Tomonori Habuchi, Brian I Rini, Ying Chen, Angel H Bair, Seiichiro Ozono, Seiji Naito, Hideyuki Akaza
OBJECTIVES: To conduct Japanese subgroup analyses of a randomized, global Phase II study of axitinib with and without dose titration in first-line metastatic renal cell carcinoma and to explore predictive factors for axitinib efficacy in first-line metastatic renal cell carcinoma. METHODS: The data included 44 Japanese and 169 non-Japanese treatment-naïve patients with metastatic renal cell carcinoma. Patients received twice-daily axitinib 5 mg during a 4-week lead-in period...
August 29, 2016: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27569574/effect-of-patient-education-for-diabetic-outpatients-by-a-hospital-pharmacist-a-retrospective-study
#19
Yuko Ichiki, Daisuke Kobayashi, Toshio Kubota, Sahoko Ozono, Aya Murakami, Yusuke Yamakawa, Kazuya Zeki, Takao Shimazoe
 The number of patients with diabetes continues to increase in Japan, which means that education in disease management is important. However, there have been few investigations into the importance of hospital pharmacists performing outpatient education for diabetes mellitus in Japan. In the diabetes outpatient department of Kitakyushu City Moji Hospital, a pharmacist commenced patient education using check sheets before patients saw the physicians from 2012. We divided the patients into groups with an increase or decrease of hemoglobin A1c (HbA1c) level after 6 months from the start of patient education...
December 1, 2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27561677/gene-therapy-improves-dental-manifestations-in-hypophosphatasia-model-mice
#20
R Okawa, O Iijima, M Kishino, H Okawa, S Toyosawa, H Sugano-Tajima, T Shimada, T Okada, K Ozono, T Ooshima, K Nakano
BACKGROUND AND OBJECTIVE: Hypophosphatasia is a rare inherited skeletal disorder characterized by defective bone mineralization and deficiency of tissue non-specific alkaline phosphatase (TNSALP) activity. The disease is caused by mutations in the liver/bone/kidney alkaline phosphatase gene (ALPL) encoding TNSALP. Early exfoliation of primary teeth owing to disturbed cementum formation, periodontal ligament weakness and alveolar bone resorption are major complications encountered in oral findings, and discovery of early loss of primary teeth in a dental examination often leads to early diagnosis of hypophosphatasia...
August 26, 2016: Journal of Periodontal Research
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