keyword
MENU ▼
Read by QxMD icon Read
search

bradykinin

keyword
https://www.readbyqxmd.com/read/29130992/genetic-determinants-of-c1-inhibitor-deficiency-angioedema-age-of-onset
#1
Panagiota Gianni, Gedeon Loules, Maria Zamanakou, Maria Kompoti, Dorottya Csuka, Fotis Psarros, Markus Magerl, Dimitru Moldovan, Marcus Maurer, Matthaios G Speletas, Henriette Farkas, Anastasios E Germenis
BACKGROUND: In view of the large heterogeneity in the clinical presentation of hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE), great efforts are being made towards detecting measurable biological determinants of disease severity that can help to improve the management of the disease. Considering the central role that plasma kallikrein plays in bradykinin production, we investigated the contribution of the functional polymorphism KLKB1-428G/A to the disease phenotype...
November 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29122812/nebivolol-but-not-metoprolol-treatment-improves-endothelial-fibrinolytic-capacity-in-adults-with-elevated-blood-pressure
#2
Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza
BACKGROUND: Vascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND RESULTS: Forty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo...
November 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113802/desflurane-inhibits-endothelium-dependent-vasodilation-more-than-sevoflurane-with-inhibition-of-endothelial-nitric-oxide-synthase-by-different-mechanisms
#3
Satoshi Kazuma, Yasuyuki Tokinaga, Yukimasa Takada, Ryu Azumaguchi, Motonobu Kimizuka, Shunsuke Hayashi, Michiaki Yamakage
The effects of desflurane on endothelium-dependent vasodilation remain uncertain, whereas sevoflurane is known to inhibit it. Endothelium-dependent vasodilation is mainly mediated by endothelial nitric oxide synthase. The effects of desflurane on endothelium-dependent vasodilation were compared with those of sevoflurane, and inhibition mechanisms, including phosphorylation of endothelial nitric oxide synthase and the calcium pathway, were evaluated for the two anesthetics. We hypothesized that desflurane would inhibit endothelium-dependent vasodilation in a concentration-dependent manner more than sevoflurane, with inhibition of a calcium pathway...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29112487/pharmacotherapy-for-angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-systematic-review
#4
Claire M Lawlor, Ashwin Ananth, Blair M Barton, Thomas C Flowers, Edward D McCoul
Objective Angioedema is a potentially life-threatening complication of angiotensin-converting enzyme inhibitor (ACEI) use, occurring in up to 0.5% of users. Although the pathophysiology of ACEI-induced angioedema is attributable to elevated serum bradykinin, standard management typically includes corticosteroids and antihistamines. We sought to summarize the evidence supporting pharmacotherapy for ACEI-induced angioedema. Data Sources PubMed, MEDLINE, and Embase portals. Methods A systematic literature review was conducted according to the PRISMA guidelines...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29107952/hereditary-angioedema-assessing-the-hypothesis-for-underlying-autonomic-dysfunction
#5
Maddalena A Wu, Francesco Casella, Francesca Perego, Chiara Suffritti, Nada Afifi Afifi, Eleonora Tobaldini, Andrea Zanichelli, Chiara Cogliati, Nicola Montano, Marco Cicardi
BACKGROUND: Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes. OBJECTIVE: Our study evaluates the relationship between autonomic nervous system (ANS) and contact/complement system activation. METHODS: Twenty-three HAE patients (6 males, mean age 47.5±11.4 years) during remission and 24 healthy controls (8 males, mean age 45.3±10.6 years) were studied. ECG, beat-by-beat blood pressure, respiratory activity were continuously recorded during rest (10') and 75-degrees-head-up tilt (10')...
2017: PloS One
https://www.readbyqxmd.com/read/29101168/genetically-increased-angiotensin-i-converting-enzyme-alters-peripheral-and-renal-vascular-reactivity-to-angiotensin-ii-and-bradykinin-in-mice
#6
Catherine Chollet, Sandrine Placier, Christos Chatziantoniou, Annette Hus-Citharel, Nathalie Caron, Ronan Roussel, Francois Alhenc-Gelas, Nadine Bouby
Angiotensin 1-converting enzyme (ACE) levels in man are under strong genetic influence. Genetic variation in ACE has been linked to risk for, and progression of, cardiovascular and renal diseases. Causality has been documented in genetically modified mice but mechanisms underlying causality are not completely elucidated. To further document the vascular and renal consequences of a moderate genetic increase in ACE synthesis, we studied genetically modified mice carrying three copies of the ACE gene (3-copy mice) and littermate wild type animals (2-copy mice)...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29098020/renin-angiotensin-system-deregulation-as-renal-cancer-risk-factor
#7
Paweł Sobczuk, Cezary Szczylik, Camillo Porta, Anna M Czarnecka
For numerous years, the non-cardiovascular role of the renin-angiotensin system (RAS) was underestimated, but recent studies have advanced the understanding of its function in various processes, including carcinogenesis. Numerous evidence comes from preclinical and clinical studies on the use of antihypertensive agents targeting the RAS, including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers. It has been demonstrated that the use of ACEIs can alter the incidence of renal cell carcinoma (RCC) and may have a positive effect by prolonging patient survival...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29096869/prospective-crossover-study-for-a-standardized-comparison-of-the-dextrane-sulfate-whole-blood-and-plasma-apheresis-system-in-patients-with-cardiovascular-disease-and-severe-dyslipidemia
#8
Wolfgang Ramlow, Heinrich Prophet, Grit Waitz
BACKGROUND AND AIMS: The objective of this study was a standardized comparison of the safety and effectiveness of the Kaneka (Kaneka Corporation, Osaka, Japan) whole blood (Liposorber DL-100) and plasma (Liposorber LA-15) lipoprotein apheresis (LA) system to optimize the individual therapy of patients with cardiovascular disease and severe dyslipidemia. METHODS: Six chronic LA patients with a pre-treatment LDL-C < 6 mmol/l in steady state received a total of three treatments with the LA-15 device, followed by three treatments with the DL-100 device or vice versa...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29090005/the-modular-nature-of-bradykinin-potentiating-peptides-isolated-from-snake-venoms
#9
REVIEW
Juliana Mozer Sciani, Daniel Carvalho Pimenta
Bradykinin-potentiating peptides (BPPs) are molecules discovered by Sergio Ferreira - who found them in the venom of Bothrops jararaca in the 1960s - that literally potentiate the action of bradykinin in vivo by, allegedly, inhibiting the angiotensin-converting enzymes. After administration, the global physiological effect of BPP is the decrease of the blood pressure. Due to this interesting effect, one of these peptides was used by David Cushman and Miguel Ondetti to develop a hypotensive drug, the widely known captopril, vastly employed on hypertension treatment...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29089149/oxidative-stress-in-the-optic-nerve-and-cortical-visual-area-of-steptozotocin-induced-diabetic-wistar-rats-blockade-with-a-selective-bradykinin-b1-receptor-antagonist
#10
Orlando L Catanzaro, Jorgelina Aira Capponi, Irene Di Martino, Emilio S Labal, Pierre Sirois
The role of bradykinin B1 receptors on the oxidative stress as measured by the levels of Na+/K+ ATPase activity, malondialdehyde (MDA) and glutathione (GSH) in male Wistar rat optic nerve and visual cortex area 1 and 4weeks after STZ treatment was studied. Rats were divided into 4 groups (n=6-7): 1. Controls (non-diabetics); 2. Diabetics (65mg/kg streptozotocin, STZ); 3. Diabetics injected with B1 antagonist R-954 (2mg/Kg) during the last 3days of a one week period; 4. Diabetics injected with B1 antagonist R-954 (2mg/Kg) during the last 3days of a 4week period...
October 28, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29072555/streptococcus-gallolyticus-subsp-gallolyticus-endocarditis-isolate-interferes-with-coagulation-and-activates-the-contact-system
#11
Julia Isenring, Juliane Köhler, Masanobu Nakata, Marcus Frank, Christoph Jans, Pierre Renault, Camille Danne, Shaynoor Dramsi, Bernd Kreikemeyer, Sonja Oehmcke-Hecht
Streptococcus gallolyticus subsp. gallolyticus, formerly classified as S. bovis biotype I, is an increasing cause of bacteremia and infective endocarditis in the elderly. The physiopathology of infective endocarditis is poorly understood and involves immune and coagulation systems. In this study, we found that S. gallolyticus subsp. gallolyticus activates the human contact system, which in turn has two consequences: cleavage of high-molecular-weight kininogen (HK) resulting in release of the potent pro-inflammatory peptide bradykinin, and initiation of the intrinsic pathway of coagulation...
October 26, 2017: Virulence
https://www.readbyqxmd.com/read/29071730/transforming-growth-factor-%C3%AE-enhances-rho-kinase-activity-and-contraction-in-airway-smooth-muscle-via-the-nucleotide-exchange-factor-arhgef1
#12
Yasin Shaifta, Charles E MacKay, Nneka Irechukwu, Katie A O'Brien, David B Wright, Jeremy P T Ward, Greg A Knock
Transforming growth factor-β (TGF-β), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been implicated in airway hyper-responsiveness, but how they interact in order to regulate airway smooth muscle contractility is not fully understood. We found that TGF-β pre-treatment enhanced acute contractile responses to bradykinin (BK) in isolated rat bronchioles, and inhibitors of RhoGEFs (Y16) and Rho-kinase (Y27632), but not the SrcFK inhibitor PP2 prevented this enhancement. In cultured human airway smooth muscle cells (hASMC), TGF-β pre-treatment enhanced the protein expression of the Rho guanine nucleotide exchange factor ARHGEF1, MLC20 , MYPT-1 and the actin-severing protein cofilin, but not of RhoA, ROCK2 or c-Src...
October 25, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29071111/impact-of-pioglitazone-and-bradykinin-type-1-receptor-antagonist-on-type-2-diabetes-in-high-fat-diet-fed-c57bl-6j-mice
#13
S El Akoum, Y Haddad, R Couture
AIM: Type 2 diabetes (T2D) is a major complication of obesity and a leading cause of morbidity and mortality. Antagonizing bradykinin type 1 receptor (B1R) improved body and tissue fat mass and reversed vascular and adipose tissue inflammation in a rat model of insulin resistance. This study aimed at evaluating further the role of B1R in a mouse model of T2D by comparing the antidiabetic and anti-inflammatory effects of the B1R antagonist SSR240612 (SSR) in adipose tissue with those of pioglitazone (TZD), an activator of peroxisome proliferator-activated receptor gamma...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29059213/endothelial-camkii-as-a-regulator-of-enos-activity-and-no-mediated-vasoreactivity
#14
Shubha Murthy, Olha M Koval, Juan M Ramiro Diaz, Santosh Kumar, Daniel Nuno, Jason A Scott, Chantal Allamargot, Linda J Zhu, Kim Broadhurst, Velarchana Santhana, William J Kutschke, Kaikobad Irani, Kathryn G Lamping, Isabella M Grumbach
The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine kinase important in transducing intracellular Ca2+ signals. While in vitro data regarding the role of CaMKII in the regulation of endothelial nitric oxide synthase (eNOS) are contradictory, its role in endothelial function in vivo remains unknown. Using two novel transgenic models to express CaMKII inhibitor peptides selectively in endothelium, we examined the effect of CaMKII on eNOS activation, NO production, vasomotor tone and blood pressure...
2017: PloS One
https://www.readbyqxmd.com/read/29056074/2d-lc-ms-ms-to-measure-cleaved-high-molecular-weight-kininogen-in-human-plasma-as-a-biomarker-for-c1-inh-hae
#15
Guodong Zhang, Daniel J Sexton, Ryan R Faucette, Yongchang Qiu, Jiang Wu
AIM: C1-INH-HAE is caused by activation of plasma kallikrein which subsequently cleaves high-molecular-weight kininogen (HMWK) to generate bradykinin and cHMWK. MATERIALS & METHODS: A novel ion-pair 2D LC-MS/MS assay was developed to measure the 46 kDa cHMWK in plasma as a biomarker for C1-INH-HAE. The sample preparation included sodium dodecyl sulfate denaturation, methanol crash, chymotryptic digestion and peptide enrichment by solid phase extraction. RESULTS: The LLOQ was 200 ng/ml...
October 21, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29038201/kinin-b1-receptor-promotes-neurogenic-hypertension-through-activation-of-centrally-mediated-mechanisms
#16
Srinivas Sriramula, Eric Lazartigues
Hypertension is associated with increased activity of the kallikrein-kinin system. Kinin B1 receptor (B1R) activation leads to vasoconstriction and inflammation. Despite evidence supporting a role for the B1R in blood pressure regulation, the mechanisms by which B1R could alter autonomic function and participate in the pathogenesis of hypertension remain unidentified. We sought to explore whether B1R-mediated inflammation contributes to hypertension and investigate the molecular mechanisms involved. In this study, we tested the hypothesis that activation of B1R in the brain is involved in the pathogenesis of hypertension, using the deoxycorticosterone acetate-salt model of neurogenic hypertension in wild-type and B1R knockout mice...
December 2017: Hypertension
https://www.readbyqxmd.com/read/29034546/bradykinin-system-is-involved-in-endometriosis-related-pain-through-endothelin-1-production
#17
O Yoshino, K Yamada-Nomoto, M Kobayashi, T Andoh, M Hongo, Y Ono, A Hasegawa-Idemitsu, A Sakai, Y Osuga, S Saito
BACKGROUND: Endometriosis is a gynaecological disease exhibiting severe pelvic pain, but the mechanism of pain production remains unknown. Bradykinin (BK) is known as an inflammatory mediator, and shows elevated levels in inflammatory diseases such as rheumatoid arthritis. In the present study, we evaluated whether BK is involved in endometriosis-related pain. METHODS: Endometriotic lesions were used for immunohistochemistry. Primary cultures of endometriotic stromal cells (ESC) were stimulated with IL-1β and/or BK...
October 16, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29032334/anti-hypersensitivity-effects-of-the-phthalimide-derivative-n-4methyl-phenyl-4-methylphthalimide-in-different-pain-models-in-mice
#18
Gislaine Francieli da Silva, Mariana Ferreira Dos Anjos, Lilian Wunsch Rocha, Luiz Felipe Gomes Rebello Ferreira, Dorimar Serafim Stiz, Rogério Corrêa, Jose Roberto Santin, Valdir Cechinel Filho, Marcelo Zaldini Hernandes, Nara Lins Meira Quintão
The treatment of chronic pain remains a challenge for clinicians worldwide, independent of its pathogenesis. It motivates several studies attempting to discover strategies to treat the disease. The in silico analysis using molecular docking approach demonstrated that the phthalimide N-(4methyl-phenyl)-4-methylphthalimide (MPMPH-1) presented high affinity to adenylyl-cyclase enzyme (AC). It also prominently reduced the mechanical hypersensitivity of mice challenged by Forskolin, an AC activator. This effect lasted for up to 48h after Forskolin injection, presenting activity longer than MDL-12330A (AC inhibitor)...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29027317/exposure-to-omentum-adipose-tissue-conditioned-medium-from-obese-pregnant-women-promotes-myometrial-artery-dysfunction
#19
Christina E Hayward, Elizabeth J Cowley, Colin P Sibley, Jenny E Myers, Mark Wareing
AIM: Underlying mechanisms of poor pregnancy outcome in obese (OB) mothers (body mass index [BMI] ≥ 30 kg/m(2) ) are unknown. Our studies demonstrate that OB pregnant women have altered myometrial artery (MA) function related to the thromboxane and nitric oxide pathways. In obesity, increased central fat mass is associated with an altered endocrine milieu. We tested the hypothesis that in OB pregnant women the omentum, a central fat store, releases factors that promote dysfunction in normal MAs...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28994183/angiotensin-converting-enzyme-inhibitor-induced-angioedema-a-review-of-the-literature
#20
REVIEW
Teresa Brown, Jimmy Gonzalez, Catherine Monteleone
According to the National Health and Nutrition Examination Survey 2012, one third of antihypertensive prescriptions in the United States in the past decade were for angiotensin-converting enzyme inhibitors (ACEIs). An important and serious side effect of ACEIs is angioedema caused by a reduction in bradykinin degradation. In a national medical chart abstraction study conducted at the US Veterans Affairs Health Care System in 2008, 0.20% of ACEI initiators developed angioedema while on the medication. The angiotensin-converting enzyme is a part of the renin-angiotensin system that converts angiotensin I to angiotensin II...
October 10, 2017: Journal of Clinical Hypertension
keyword
keyword
34481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"