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Optical coherence tomography

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https://www.readbyqxmd.com/read/29150681/the-structure-function-relationship-measured-with-optical-coherence-tomography-and-a-microperimeter-with-auto-tracking-the-mp-3-in-patients-with-retinitis-pigmentosa
#1
Yuichi Asahina, Marie Kitano, Yohei Hashimoto, Mieko Yanagisawa, Hiroshi Murata, Tatsuya Inoue, Ryo Obata, Ryo Asaoka
The purpose of the current study was to investigate the structure-function relationship in patients with retinitis pigmentosa (RP) using optical coherence tomography and the MP-3 microperimeter. Visual field (VF) measurements were carried out using MP-3 microperimetry and the Humphrey Field Analyzer (HFA, Carl-Zeiss, CA), 22 eyes of 11 patients with a clinical diagnosis of RP, both with the 10-2 test grid pattern. Optical coherence tomography (OCT, Spectralis, Heidelberg, Germany) was also performed and the ellipsoid zone (EZ) was identified in the OCT image...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#2
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29149542/spectrally-encoded-coherence-tomography-and-reflectometry-sectr-simultaneous-en-face-and-cross-sectional-imaging-at-2-gigapixels-per-second
#3
Mohamed T El-Haddad, Ivan Bozic, Yuankai K Tao
Non-invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast-free high-resolution three-dimensional imaging in non-fluorescent scattering tissues. However, sample motion remains a critical barrier to raster-scanned acquisition and reconstruction of wide-field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography and reflectometry (SECTR), a high-speed multimodality system for simultaneous OCT and spectrally-encoded reflectance (SER) imaging...
November 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29149239/label-free-in-vivo-imaging-of-corneal-lymphatic-vessels-using-microscopic-optical-coherence-tomography
#4
Jens Horstmann, Hinnerk Schulz-Hildebrandt, Felix Bock, Sebastian Siebelmann, Eva Lankenau, Gereon Hüttmann, Philipp Steven, Claus Cursiefen
Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). Methods: Corneal neovascularization was induced by intrastromal placement of 11...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29149238/diabetic-neuroglial-changes-in-the-superficial-and-deep-nonperfused-areas-on-optical-coherence-tomography-angiography
#5
Yoko Dodo, Tomoaki Murakami, Kiyoshi Suzuma, Shin Yoshitake, Tatsuya Yoshitake, Kenji Ishihara, Masahiro Fujimoto, Yuko Miwa, Akitaka Tsujikawa
Purpose: To evaluate the relationship between lamellar capillary nonperfusion on optical coherence tomography angiography (OCTA) images and neuroglial changes on structural optical coherence tomography (OCT) images in diabetic retinopathy (DR). Methods: We retrospectively reviewed 101 consecutive eyes of 69 patients with DR. OCTA and OCT images within a 3 × 3-mm square centered on the fovea were acquired simultaneously. The nonperfused areas (NPAs) in the superficial capillary layer (sNPA) (from the nerve fiber layer [NFL] to the inner plexiform layer [IPL]), the deep layer (dNPA) (corresponding mainly to the inner nuclear layer [INL]), or both layers (bNPA) were measured individually along 10 transverse lines...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29148965/nonclinical-safety-assessment-of-anti-factor-d-key-strategies-and-challenges-for-the-nonclinical-development-of-intravitreal-biologics
#6
Vladimir Bantseev, Rebecca Erickson, Douglas Leipold, Caroline Amaya, Paul E Miller, Helen Booler, Evan A Thackaberry
PURPOSE: The nonclinical toxicology program described here was designed to characterize the safety profile of anti-factor D (AFD; FCFD4514S, lampalizumab) to support intravitreal (ITV) administration in patients with geographic atrophy (GA). METHODS: The toxicity of AFD was assessed in a single-dose and 6-month repeat-dose study in monkeys at doses up to 10 mg/eye. Toxicity was assessed by clinical ophthalmic examinations, intraocular pressure measurements, ocular photography, electroretinography, fluorescein angiography, optical coherence tomography, and anatomic pathology...
November 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29148864/morphologic-criteria-of-lesion-activity-in-neovascular-age-related-macular-degeneration-a-consensus-article
#7
Stefania Miotto, Nicola Zemella, Elena Gusson, Giacomo Panozzo, Sandro Saviano, Giuseppe Scarpa, Giorgio Boschi, Stefano Piermarocchi
Intravitreal antivascular endothelial growth factor drugs represent the current standard of care for neovascular age-related macular degeneration (nAMD). Individualized treatment regimens aim at obtaining the same visual benefits of monthly injections with a reduced number of injections and follow-up visits, and, consequently, of treatment burden. The target of these strategies is to timely recognize lesion recurrence, even before visual deterioration. Early detection of lesion activity is critical to ensure that clinical outcomes are not compromised by inappropriate delays in treatment, but questions remain on how to effectively monitor the choroidal neovascularization (CNV) activity...
November 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29148533/identifying-characteristic-features-of-the-retinal-and-choroidal-vasculature-in-choroideremia-using-optical-coherence-tomography-angiography
#8
A Abbouda, A M Dubis, A R Webster, M Moosajee
PurposeUsing optical coherence tomography angiography (OCTA) to investigate the area with flow in the superficial retinal vessel network (SVRN) and choriocapillaris (CC) layer among male subjects with choroideremia (CHM), female carriers, and normal controls to identify vascular changes.Patients and methodsImages of SRVN and CC layer were acquired in 9 affected males, 5 female carriers, and 14 age- and gender-matched controls using the Angiovue software of the RTVue XR Avanti.ResultsThe mean age was 33 years for affected male CHM patients (median 30 years), 46 years for female carriers (median 53 years), and 39 years for controls (median 38...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148525/differences-in-photoreceptor-recovery-among-patients-and-between-different-parts-of-the-posterior-pole-in-vogt-koyanagi-harada-disease
#9
M Zhou, R P Gu, Z Sun, C H Jiang, Q Chang, G Z Xu
PurposeTo investigate the recovery of photoreceptors following the treatment in Vogt-Koyanagi-Harada (VKH) disease.Patients and methodsThis was a retrospective study. We enrolled 28 patients with VKH (56 eyes). The clinical and optical coherence tomography (OCT) findings were recorded for 12 months after treatment. The patterns of photoreceptor recovery on OCT were defined: pattern F group=Foveal photoreceptor recovery visible first; pattern E group=Extrafoveal photoreceptor recovery visible first; and pattern S group=Simultaneous foveal and extrafoveal photoreceptor recovery...
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148272/adolf-friedrich-fercher-a-pioneer-of-biomedical-optics
#10
Christoph K Hitzenberger
Adolf Friedrich Fercher, an outstanding pioneer of biomedical optics, passed away earlier this year. He was a brilliant and visionary researcher who pioneered various fields of biomedical optics, such as laser speckle flowgraphy, tissue interferometry, and optical coherence tomography (OCT). On the occasion of the 25th anniversary of OCT, this paper reviews and commemorates Fercher's pioneering work.
November 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29148032/secondary-glaucoma-in-uveitis-comparison-of-the-optic-nerve-head-morphology-among-a-nonmydriatic-fundus-camera-hrt-and-sd-oct
#11
Milena Pahlitzsch, Matthias K J Klamann, Saskia Jacob, Carl Erb, Sibylle Winterhalter, Necip Torun, Anna-Karina B Maier, Eckart Bertelmann
PURPOSE: To assess the correlation between the disc damage likelihood scale (DDLS) objectively measured by a nonmydriatic fundus camera, confocal laser scanning ophthalmoscopy (HRT3), and spectral-domain optical coherence tomography (SD-OCT) in uveitic glaucoma. METHODS: A total of 59 patients with uveitic glaucoma (21 female, 38 male; mean age 56.8 ± 18.7 years) were included in this prospective cross-sectional study. All patients were measured by the Kowa Nonmyd WX 3D camera (2D/3D nonmydriatic retinal camera, Kowa Company), the HRT3 (Heidelberg Engineering), and SD-OCT (Carl Zeiss Meditec) by one examiner on the same day...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29148030/incidence-and-quantitative-analysis-of-dissociated-optic-nerve-fiber-layer-appearance-real-loss-of-retinal-nerve-fiber-layer
#12
Yoon J Kim, Kyoung S Lee, Soo G Joe, June-Gone Kim
PURPOSE: To assess the association between appearance of dissociated optic nerve fiber layer (DONFL) after internal limiting membrane (ILM) peeling and changes in the macular nerve fiber layer (NFL) area by spectral-domain optical coherence tomography (SD-OCT). METHODS: This study included 132 consecutive patients who had successfully undergone vitrectomy with ILM peeling for idiopathic epiretinal membrane or macular holes and had been followed up for ≥6 months...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29147565/operating-room-central-serous-chorioretinopathy
#13
Ahmad M Mansour, Rola Hamam
Objectives: The operating room is a place of surgical intervention with its accompanying bodily and cognitive strain on the performers. Stress in the operating room may lead to the onset of central serous chorioretinopathy as reported hereby in a retina surgeon and is labeled as operating room central serous chorioretinopathy. Methods: The same operator performed the optical coherence tomography scans on one retina surgeon. A masked observer estimated the maximal height of the subretinal fluid...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29147104/predictors-of-intraocular-pressure-after-phacoemulsification-in-primary-open-angle-glaucoma-eyes-with-wide-versus-narrower-angles-an-american-ophthalmological-society-thesis
#14
Shan C Lin, Marisse Masis, Travis C Porco, Louis R Pasquale
Purpose: To assess if narrower-angle status and anterior segment optical coherence tomography (AS-OCT) parameters can predict intraocular pressure (IOP) drop in primary open-angle glaucoma (POAG) patients after cataract surgery. Methods: This was a prospective case series of consecutive cataract surgery patients with POAG and no peripheral anterior synechiae (PAS) using a standardized postoperative management protocol. Preoperatively, patients underwent gonioscopy and AS-OCT...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29145690/-visual-analysis-of-retinal-oct-data
#15
Martin Röhlig, Anselm Jünemann, Dagmar-Christiane Fischer, Ruby Kala Prakasam, Oliver Stachs, Heidrun Schumann
Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29145603/accuracy-of-next-generation-sequencing-for-molecular-diagnosis-in-patients-with-infantile-nystagmus-syndrome
#16
John Hoon Rim, Seung-Tae Lee, Heon Yung Gee, Byung Joo Lee, Jong Rak Choi, Hye Won Park, Sueng-Han Han, Jinu Han
Importance: Infantile nystagmus syndrome (INS) is a group of disorders presenting with genetic and clinical heterogeneities that have challenged the genetic and clinical diagnoses of INS. Precise molecular diagnosis in early infancy may result in more accurate genetic counseling and improved patient management. Objective: To assess the accuracy of genomic data from next-generation sequencing (NGS) and phenotypic data to enhance the definitive diagnosis of INS. Design, Setting, and Participants: A single-center retrospective case series was conducted in 48 unrelated, consecutive patients with INS, with or without associated ocular or systemic conditions, who underwent genetic testing between June 1, 2015, and January 31, 2017...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29145445/a-new-approach-by-optical-coherence-tomography-for-elucidating-biofilm-formation-by-emergent-candida-species
#17
Melyna Chaves Leite de Andrade, Marcos Andre Soares de Oliveira, Franz de Assis Graciano Dos Santos, Pamella de Brito Ximenes Vilela, Michellangelo Nunes da Silva, Danielle Patrícia Cerqueira Macêdo, Reginaldo Gonçalves de Lima Neto, Henrique Jonh Pereira Neves, Ildnay de Souza Lima Brandão, Guilherme Maranhão Chaves, Renato Evangelista de Araujo, Rejane Pereira Neves
The majority of microorganisms present a community lifestyle, establishing biofilm ecosystems. However, little is known about its formation in emergent Candida species involved in catheter-related infections. Thus, various techniques may be used in the biofilm detection to elucidate structure and clinical impact. In this context, we report the ability of emergent Candida species (Candida haemulonii, C. lusitaniae, C. pelliculosa, C.guilliermondii, C. famata and C. ciferrii) on developing well structured biofilms with cell viability and architecture, using optical coherence tomography (OCT)...
2017: PloS One
https://www.readbyqxmd.com/read/29143429/an-overview-of-methods-to-mitigate-artifacts-in-optical-coherence-tomography-imaging-of-the-skin
#18
Saba Adabi, Audrey Fotouhi, Qiuyun Xu, Steve Daveluy, Darius Mehregan, Adrian Podoleanu, Mohammadreza Nasiriavanaki
BACKGROUND: Optical coherence tomography (OCT) of skin delivers three-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution modality, OCT images suffer from some artifacts that lead to misinterpretation of tissue structures. Therefore, an overview of methods to mitigate artifacts in OCT imaging of the skin is of paramount importance. Speckle, intensity decay, and blurring are three major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT...
November 16, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/29143216/self-perception-and-determinants-of-color-vision-in-parkinson-s-disease
#19
Alexander U Brandt, Hanna G Zimmermann, Timm Oberwahrenbrock, Justine Isensee, Thomas Müller, Friedemann Paul
Visual dysfunction is common in patients with Parkinson's disease (PD). The objective of this study was to investigate the perceived impact of visual dysfunction and especially color vision loss on PD patients, and to identify retinal and disease factors associated with color vision. Thirty PD patients and thirty-four healthy controls were included. Participants performed the Farnsworth-Munsell Hue-100 test (FMT). Patients answered the National Eye Institute Visual Function Questionnaire (NEI-VFQ), Unified Parkinson's Disease Rating Scale (UPDRS) assessment, and underwent optical coherence tomography with measurement of retinal nerve fiber layer, ganglion cell layer + inner plexiform layer (GCIPL), and outer nuclear and photoreceptor layer...
November 15, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29142888/effect-of-intravitreal-injection-of-bevacizumab-on-acute-central-serous-chorioretinopathy-patients-who-visited-feiz-hospital-during-2014-2015-period
#20
Mohamad Reza Akhlaghi, Cobra Nasrollahi, Seyed Mohamad Namgar, Farzan Kianersi, Ali Reza Dehghani, Reza Arefpour
Background: Aim of this clinical trial is the evaluation of the effect of intravitreal injection of bevacizumab on acute central serous chorioretinopathy (CSC). Materials and Methods: In a nonrandomized clinical trial, 36 CSC eyes (with <1-month disease history) were examined. Initially, all the patients underwent posterior and anterior segment examinations as well as complete eye examination to evaluate the best spectacle-corrected visual acuity (BSCVA). Then, optical coherence tomography was performed to confirm the diagnosis...
2017: Advanced Biomedical Research
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