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Optical coherence tomography

Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
Xiaohong Liu, Hehua Ye, Qi Zhang, Xuan Cai, Wenjing Yu, Siyi Yu, Tianyu Wang, Wuyi Lu, Xiang Li, Peiquan Zhao
BACKGROUND: Myopia subjects usually have long axial lengths and are predisposed to deep anterior chamber depths and open angles. Jiangning eye study is a randomized, population based study in Shanghai to determine whether myopia has an effect on the prevalence of occludable angles. METHODS: A total of 2478 residents aged 50 years and over were randomly selected, and 2044 (82.5%) individuals of them participated in ophthalmic examinations between November 2012 and February 2013...
2016: PloS One
Sang-Yoon Lee, Eun Kyoung Lee, Ki Ho Park, Dong Myung Kim, Jin Wook Jeoung
PURPOSE: To report an asymmetry analysis of macular inner retinal layers using swept-source optical coherence tomography (OCT) and to evaluate the utility for glaucoma diagnosis. DESIGN: Observational, cross-sectional study. PARTICIPANTS: Seventy normal healthy subjects and 62 glaucoma patients. METHODS: Three-dimensional scans were acquired from 70 normal subjects and 62 open angle glaucoma patients by swept-source OCT...
2016: PloS One
C Andres Benatti, Natalie A Afshari
PURPOSE OF REVIEW: The review updates the mechanisms, clinical presentation, diagnosis, and management of Descemet membrane detachment after cataract surgery, particularly during cataract surgery. RECENT FINDINGS: The advent of new imaging techniques like the anterior segment optical coherence tomography and a better comprehension of the clinical and pathological aspects of detachment, has improved the diagnosis and treatment of this complication to the extent that the first algorithms and protocols have been proposed...
October 19, 2016: Current Opinion in Ophthalmology
Jayanth Sridhar, Abtin Shahlaee, Wen-Shi Shieh, Ehsan Rahimy
PURPOSE: To report a single case of paracentral acute middle maculopathy in association with retinal artery occlusion in the setting of ipsilateral facial cosmetic filler injection. METHODS: Case report. PATIENT: A 35-year-old woman presenting with sudden vision loss to finger count vision immediately after left nasal fat pad cosmetic filler injection. RESULTS: Dilated funduscopic examination revealed a swollen optic disc with multiple branch arterial occlusions with visible embolic material...
October 19, 2016: Retinal Cases & Brief Reports
Vasilios P Papastefanou, Clara Vázquez-Alfageme, Pearse A Keane, Mandeep S Sagoo
PURPOSE: Multimodality image analysis of two cases of torpedo maculopathy. METHODS: Imaging with fundus photography, autofluorescence (AF), swept-source optical coherence tomography (OCT), en face OCT, and OCT angiography. RESULTS: The basal diameter of the torpedo lesions was 1 mm × 2 mm. One case had a satellite lesion. Autofluorescence indicated variable loss of signal. Swept-source OCT and en face OCT demonstrated fundus excavation, attenuation of nuclear layers and disruption of the outer plexiform layer, loss of photoreceptors and a subretinal cleft...
October 19, 2016: Retinal Cases & Brief Reports
Dierck Hillmann, Hendrik Spahr, Carola Hain, Helge Sudkamp, Gesa Franke, Clara Pfäffle, Christian Winter, Gereon Hüttmann
Certain topics in research and advancements in medical diagnostics may benefit from improved temporal and spatial resolution during non-invasive optical imaging of living tissue. However, so far no imaging technique can generate entirely diffraction-limited tomographic volumes with a single data acquisition, if the target moves or changes rapidly, such as the human retina. Additionally, the presence of aberrations may represent further difficulties. We show that a simple interferometric setup-based on parallelized optical coherence tomography-acquires volumetric data with 10 billion voxels per second, exceeding previous imaging speeds by an order of magnitude...
October 20, 2016: Scientific Reports
Jiang Zhu, Li Qi, Yusi Miao, Teng Ma, Cuixia Dai, Yueqiao Qu, Youmin He, Yiwei Gao, Qifa Zhou, Zhongping Chen
Elastography provides a powerful tool for histopathological identification and clinical diagnosis based on information from tissue stiffness. Benefiting from high resolution, three-dimensional (3D), and noninvasive optical coherence tomography (OCT), optical micro-elastography has the ability to determine elastic properties with a resolution of ~10 μm in a 3D specimen. The shear wave velocity measurement can be used to quantify the elastic modulus. However, in current methods, shear waves are measured near the surface with an interference of surface waves...
October 20, 2016: Scientific Reports
Markus Reinholz, Hannah Schwaiger, Julian Poetschke, Andreas Epple, Thomas Ruzicka, Tanja Von Braunmühl, Gerd G Gauglitz
BACKGROUND: Currently, different types of treatments for pathological scars are available, however, to date, there is no established method of measurement to objectively assess therapeutic outcome. Treatment success is usually evaluated clinically by the physician and patient. Non-invasive imaging techniques, such as HD-OCT (high-definition optical coherence tomography), may represent a valuable diagnostic tool to objectively measure therapeutic outcome. OBJECTIVES: To compare HD-OCT with ultrasound and subjective evaluation tools, such as questionnaires...
October 20, 2016: European Journal of Dermatology: EJD
Hirofumi Ohtani, Shigeki Kimura, Tomoyo Sugiyama, Keiichi Hishikari, Toru Misawa, Masafumi Mizusawa, Kazuto Hayasaka, Yosuke Yamakami, Keisuke Kojima, Yuichiro Sagawa, Hiroyuki Hikita, Takashi Ashikaga, Atsushi Takahashi, Mitsuaki Isobe
: Few studies have directly compared vascular responses to second-generation drug-eluting stents (DESs). We performed optical coherence tomography examinations in 56 consecutive patients with implanted single stent [19 cobalt-chromium everolimus-eluting stents (CoCr-EES), 22 platinum-chromium EES (PtCr-EES), and 15 resolute zotarolimus-eluting stents (R-ZES)] for de novo lesions, and who did not have restenosis at their 9-month follow-up. Neointimal thickness (NIT), stent apposition, and neointimal coverage were assessed in every strut...
October 19, 2016: International Journal of Cardiovascular Imaging
Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S Sulimov, Ralph Tölg, Gert Richardt, Mohamed Abdel-Wahab
This study investigated the predictors of acute recoil after implantation of everolimus-eluting BRS based on optical coherence tomography (OCT). Thirty-nine patients (56 scaffolds) were enrolled. Acute absolute recoil by quantitative coronary angiography was defined as the difference between the mean diameter of the last inflated balloon (X) and the mean lumen diameter of BRS immediately after balloon deflation (Y). Acute percent recoil was defined as (X - Y) × 100/X. Plaque eccentricity (PE) and plaque composition (PC) were assessed by OCT...
October 19, 2016: International Journal of Cardiovascular Imaging
Shumpei Obata, Masato Fujikawa, Keisuke Iwasaki, Masashi Kakinoki, Osamu Sawada, Yoshitsugu Saishin, Hajime Kawamura, Masahito Ohji
PURPOSE: To investigate anatomic changes in retinal thickness (RT) and functional changes after vitrectomy for idiopathic epiretinal membranes (ERMs) with and without internal limiting membrane (ILM) peeling. METHODS: The medical records of 100 eyes of 96 patients with ERM who underwent vitrectomy and ERM removal were reviewed retrospectively. The RT was measured by optical coherence tomography, and the area was divided into 9 sections. The best-corrected visual acuity (BCVA), 9 RT areas, and incidence rates of recurrent ERM were compared between the groups with and without ILM peeling before the operation and 12 months postoperatively...
October 20, 2016: Ophthalmic Research
Chandrakumar Balaratnasingam, Lawrence A Yannuzzi, Christine A Curcio, William H Morgan, Giuseppe Querques, Vittorio Capuano, Eric Souied, Jesse Jung, K Bailey Freund
Purpose: Drusenoid pigment epithelial detachments (PEDs) are a defined path to atrophy in age-related macular degeneration (AMD). We analyzed the relationships between retinal pigment epithelium (RPE) and drusen volume changes during the PED lifecycle, using spectral-domain optical coherence tomography (SD-OCT). Methods: Twenty-one cases of drusenoid PED tracked using SD-OCT through periods of growth and collapse were evaluated. Volumetric calculations and piece-wise linear regression analysis were used to determine the breakpoint between growth and collapse...
October 1, 2016: Investigative Ophthalmology & Visual Science
Dan Cheng, Yuqin Wang, Shenghai Huang, Qiuyan Wu, Qi Chen, Meixiao Shen, Fan Lu
Purpose: To identify macular intraretinal layer changes of patients in remission from Behcet's disease (BD) of short and long duration and evaluate the associations with visual acuity (VA). Methods: Thirty-two eyes from 26 BD patients were enrolled, including 16 eyes with a duration less than 3 years (0.5-2.5 years; BD1) and 16 eyes of longer duration (3-12 years; BD2). Their intraretinal layer thicknesses and integrity of ellipsoid zone (EZ) and interdigitation zone (IZ) were evaluated by spectral-domain optical coherence tomography (SD-OCT)...
October 1, 2016: Investigative Ophthalmology & Visual Science
Snezhina S Kostianeva, Marieta I Konareva-Kostianeva, Marin A Atanassov
AIM: To assess relationships between functional changes in visual field and structural changes in advanced open-angle glaucoma (OAG) found using spectral-domain optical coherence tomography (SD-OCT). METHODS: Thirty-one eyes of 25 patients with OAG were included in this study. Besides the routine ophthalmological exam the patients underwent standard automated perimetry (SAP) (Humphrey Field Analyzer) and SD-OCT (RTVue-100) performed within 6 months. The global perimetric indices in the study group were as follows: mean deviation (MD) 12...
September 1, 2016: Folia Medica
Rohan Chawla, Ravi Bypareddy, Koushik Tripathy, Satya Sudha Daggumili, Ankit Singh Tomar
Congenital retinal macrovessels (CRM) are rarely reported, aberrant, large branches of retinal vessels that can be both arteries and veins; however, they are more commonly veins that cross the horizontal raphe to either supply or drain the macula. In this brief report, the authors discuss optical coherence tomography angiography features of CRM in a 12-year-old male patient presenting with low visual acuity in the right eye since childhood. To the authors' knowledge, this is the first such report published in the literature...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Rohan Chawla, Kanhaiya Mittal, Rajpal Vohra
The authors report the use of optical coherence tomography angiography (OCTA) (DRI OCT Triton; Topcon, Tokyo, Japan) to localize, characterize, and confirm the presence of a choroidal neovascular membrane in a patient of focal choroidal excavation (FCE) with recent-onset metamorphopsia and visual blurring. En face OCTA images just above the level of the retinal pigment epithelium-Bruch's membrane complex typically showed the presence of a glomerulus-like neovascular network with an adjacent dark area suggestive of a Type 2 choroidal neovascularization (CNV)...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Michael I Seider, Dilraj S Grewal, Prithvi Mruthyunjaya
Portable, hand-held optical coherence tomography (OCT) revealed three clinically relevant yet not ophthalmoscopically detected or confirmed manifestations of retinoblastoma in a single patient with familial bilateral disease. Specifically, OCT showed new retinal tumors, new vitreous seeds, and tumor recurrence before they could be detected or confirmed by ophthalmoscopy. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:965-968.].
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Ricardo Noguera Louzada, Daniela Ferrara, Eduardo Amorim Novais, Eric Moult, Emily Cole, Mark Lane, James Fujimoto, Jay S Duker, Caroline R Baumal
To describe the appearance of a scleral-derived feeder vessel in a highly myopic eye with secondary choroidal neovascularization (CNV) as visualized on both en face high-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype, and a commercially available spectral-domain (SD) OCTA, with the corresponding en face and cross-sectional structural OCT images. In this case report, a 60-year-old white male presented with high myopia and secondary CNV in the right eye, previously treated with anti-vascular endothelial growth factor, and was imaged on both SD-OCT and SS-OCT...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Stefan J Lang, Bertan Cakir, Charlotte Evers, Franziska Ludwig, Clemens A K Lange, Hansjürgen T Agostini
BACKGROUND AND OBJECTIVE: The introduction of optical coherence tomography angiography (OCTA) provides new insights into the retinal vasculature. The aim of this study was to explore the value of OCTA in imaging retinal hemangioblastomas and monitoring laser treatment in patients with von Hippel-Lindau (VHL) disease. PATIENTS AND METHODS: Ten eyes of 10 patients with VHL disease were included in this retrospective case series. All patients underwent complete ophthalmological work-up including OCTA for retinal and optic nerve head hemangioblastoma...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
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