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https://www.readbyqxmd.com/read/28921035/-midportion-achilles-tendinopathy
#1
REVIEW
J Weber, T Buchhorn
Although the incidence of midportion Achilles tendinopathy is under 1% in the general population, it is quite a common disease in runners that is characterized by the symptom triad of pain, swelling and impaired physical performance. Pain and swelling are located in the area 2 to 7 cm proximal the tendon insertion onto the calcaneus.Diagnosis is made by adequate clinical symptoms and corresponding findings in sonography and/or magnetic resonance imaging scans. Histopathologically, mostly degenerative changes in the tendon structure are found, sometimes accompanied by intra- and paratendinous inflammation...
September 18, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28900820/outcome-of-childhood-leukaemia-survivors-and-necrosis-of-the-femoral-head-treated-with-autologous-mesenchymal-stem-cells
#2
T de Rojas, S Martínez-Álvarez, S Lerma-Lara, M Á Díaz, L Madero, M Ramírez
PURPOSE: Corticoid-induced osteonecrosis (ON) of femoral head can lead to severe hip joint impairment and hip replacement, with negative impact in young survivors of acute lymphoblastic leukaemia (ALL) with long life expectancy. We aim to improve quality of life in these patients with a novel approach. METHODS/PATIENTS: Based on the regenerative capacities of mesenchymal stem cells (MSCs), we performed locally implanted autologous cell therapy in two adolescents suffering of bilateral femoral ON...
September 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28879650/vascular-and-cardiac-function-in-young-adults-with-classical-congenital-adrenal-hyperplasia
#3
Joanna Wierzbicka-Chmiel, Artur Chmiel, Sławomir Rychlik, Monika Ogrodowczyk-Bobik, Bogdan Marek, Dariusz Kajdaniuk
INTRODUCTION: Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. MATERIAL AND METHODS: Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 years; twelve males) compared to 20 healthy volunteers matched for origin, sex, age, and body mass index (BMI). All of the participants were assessed for flow mediated dilatation of the brachial artery (FMD), intima-media thickness of the common carotid artery (cIMT) and common femoral artery (fIMT), standard echocardiography, and global longitudinal left ventricular function using two-dimensional speckle-tracking echocardiography (LSTE)...
September 7, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28866684/functional-connectivity-pattern-of-the-internal-hippocampal-network-in-awake-pigeons-a-resting-state-fmri-study
#4
Mehdi Behroozi, Felix Ströckens, Martin Stacho, Onur Güntürkün
In the last two decades, the avian hippocampus has been repeatedly studied with respect to its architecture, neurochemistry, and connectivity pattern. We review these insights and conclude that we unfortunately still lack proper knowledge on the interaction between the different hippocampal subregions. To fill this gap, we need information on the functional connectivity pattern of the hippocampal network. These data could complement our structural connectivity knowledge. To this end, we conducted a resting-state fMRI experiment in awake pigeons in a 7-T MR scanner...
2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28856015/antenatal-corticosteroid-treatment-for-the-prevention-of-peri-intraventricular-haemorrhage-in-preterm-newborns-a-retrospective-cohort-study-using-transfontanelle-ultrasonography
#5
Bianca A Almeida, Livia T Rios, Edward Araujo Júnior, Luciano M Nardozza, Antonio F Moron, Marília G Martins
OBJECTIVE: The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence. METHODS: We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week...
June 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28833282/palatal-perforation-and-chemical-ulcers-of-the-tongue-in-a-blind-patient
#6
Tiago Novaes Pinheiro, Flavio Fayad, Luiz Roberto Magalhães Júnior, Brigitte Nichthauser, Francisco Braga, Shirley Maria Passos
We report a unique case of a potassium aluminum sulfate oral dissolution leading to palatal chemical necrosis and extensive chemical ulcers on the tongue. The patient, a 47-year-old white, blind male, denied using cocaine or other illegal drugs that could cause such lesions. His self-medication started as a treatment for a traumatic ulcerative lesion on the hard palate. After palatal perforation, he started another self-medication routine, mixing corticoid cream and tandrilax tablets with a gauze obturator...
August 22, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28821968/near-adult-height-in-male-kidney-transplant-recipients-started-on-growth-hormone-treatment-in-late-puberty
#7
Silvia Gil, Mariana Aziz, Marta Adragna, Marta Monteverde, Alicia Belgorosky
BACKGROUND: Growth retardation and its impact on adult height is considered to be one of the most common complications in patients with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (rhGH) has been effective in improving growth in kidney transplantation (KTx) patients, but little data are available on adult height in patients who began rhGh treatment in late puberty. METHODS: Near-adult height was evaluated in 13 KTx patients treated with rhGH [growth hormone group (GHGr); dose 9...
August 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28810615/detecting-serum-and-urine-metabolic-profile-changes-of-ccl4-liver-fibrosis-in-rats-at-12-weeks-based-on-gas-chromatography-mass-spectrometry
#8
Jiarong Gao, Xiu-Juan Qin, Hui Jiang, Jin-Feng Chen, Ting Wang, Ting Zhang, Shuang-Zhi Xu, Jun-Mei Song
Liver fibrosis is caused by liver injury induced by a number of chronic liver diseases, including schistosome infection, hepatitis infection, metabolic disease, alcoholism and cholestasis. The tissue damage occurring after injury or inflammation of the liver is a reversible lesion; however, liver fibrosis has become a worldwide problem and poses a threat to human health. The development of an effective drug for the prevention and treatment of liver fibrosis is ongoing and uses information from different occurrences of liver fibrosis...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810284/-development-of-non-arteritic-anterior-ischaemic-optic-neuropathy-in-the-initially-unaffected-fellow-eye-in-patients-treated-with-systemic-corticosteroids
#9
Artur Pahor, Dusica Pahor
Background The objective of this prospective pilot study was to evaluate the results of systemic corticosteroid therapy in patient with non-arteritic anterior ischaemic neuropathy of the optical nerve (NAION) for an observation period of one year and to measure the NAION incidence in the initially healthy contralateral eye of these patients. Patients and Methods All patients diagnosed with acute NAION who were admitted to our ward during 2014 and who fulfilled all inclusion criteria for systemic corticosteroid therapy were included in the study...
August 15, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28799126/hydration-status-drug-interactions-and-determinants-in-a-spanish-elderly-population-a-pilot-study
#10
A M Puga, T Partearroyo, G Varela-Moreiras
Proper hydration is essential to maintain optimal health and well-being at all stages of life, especially for the elderly. Side effects of certain drugs that affect hydration status may compromise the health of the ancients, who also constitute the most vulnerable group. No studies have been carried out, to our knowledge, at the intersection of drugs and hydration status. Our study aimed to evaluate the effects of chronic use of certain drugs (diuretics, corticoids and metformin) in the hydration status of the elderly...
August 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28793824/dual-therapy-deflazacort-doxycyclyne-is-better-than-deflazacort-monotherapy-to-alleviate-cardiomyopathy-in-dystrophin-deficient-mdx-mice
#11
Juliano Alves Pereira, Adriana Fogagnolo Mauricio, Maria Julia Marques, Humberto Santo Neto
Cardiomyopathy related to the absence of dystrophin is an important feature in Duchenne muscular dystrophy (DMD) and in the mdx mouse. Doxycycline (DOX) could be a potential therapy for mdx skeletal muscles dystrophy. We investigated whether the corticoid deflazacort (DFZ) plus DOX could improve cardiac mdx dystrophy better than DFZ alone, later (17 months) in dystrophy. Mdx mice (8 months old) received DFZ/DOX or DFZ for 9 months. The combined therapy was greater than DFZ in reducing fibrosis (60% decrease with DFZ/DOX and 40% with DFZ alone) in the right ventricle and transforming growth factor β levels (6...
September 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28780730/the-sesquiterpene-lactone-budlein-a-inhibits-antigen-induced-arthritis-in-mice-role-of-nf-%C3%AE%C2%BAb-and-cytokines
#12
Ana C Zarpelon, Victor Fattori, Fabricio O Souto, Larissa G Pinto, Felipe A Pinho-Ribeiro, Kenji W Ruiz-Miyazawa, Walter M Turato, Thiago M Cunha, Fernando B da Costa, Fernando Q Cunha, Rubia Casagrande, Nilton S Arakawa, Waldiceu A Verri
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by debilitating pain, cartilage destruction, and loss of joint function. Management of RA includes drugs that target NF-κB and downstream cytokine production. Therefore, molecules that act by inhibiting this signaling pathway without the severe side effects of, for instance, corticoids would be suitable therapeutic strategies. Budlein A is a sesquiterpene lactone with antinociceptive and anti-inflammatory properties related to the inhibition of pro-inflammatory cytokines and neutrophil recruitment...
August 5, 2017: Inflammation
https://www.readbyqxmd.com/read/28769783/age-and-chronicity-of-administration-dramatically-influenced-the-impact-of-low-dose-paraquat-exposure-on-behavior-and-hypothalamic-pituitary-adrenal-activity
#13
Chris A Rudyk, Jessica McNeill, Natalie Prowse, Zach Dwyer, Kyle Farmer, Darcy Litteljohn, Warren Caldwell, Shawn Hayley
Little is known of the age-dependent and long-term consequences of low exposure levels of the herbicide and dopaminergic toxicant, paraquat. Thus, we assessed the dose-dependent effects of paraquat using a typical short-term (3 week) exposure procedure, followed by an assessment of the effects of chronic (16 weeks) exposure to a very low dose (1/10th of what previously induced dopaminergic neuronal damage). Short term paraquat treatment dose-dependently induced deficits in locomotion, sucrose preference and Y-maze performance...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28753818/phimosis-in-a-10-yr-old-boy-without-urinary-infection-how-to-inform-parents-against-circumcision
#14
Anne-Karoline Ebert, Maximilian Stehr
In a 10-yr-old boy with no abnormalities or symptoms other than nonretractability of the foreskin, the foreskin should be preserved. If treatment is needed, local corticoid application should be used as first-line therapy, as it gives excellent results in up to 90% of cases, before removing this sensitive part of the body.
June 20, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28744845/drug-induced-dental-caries-a-disproportionality-analysis-using-data-from-vigibase
#15
Emilie Patras de Campaigno, Inès Kebir, Jean-Louis Montastruc, Manuela Rueter, Delphine Maret, Maryse Lapeyre-Mestre, Brigitte Sallerin, Fabien Despas
INTRODUCTION: Dental caries is defined as a pathological breakdown of the tooth. It is an infectious phenomenon involving a multifactorial aetiology. The impact of drugs on cariogenic risk has been poorly investigated. OBJECTIVES: In this study, we identified drugs suspected to induce dental caries as adverse drug reactions (ADRs) and then studied a possible pathogenic mechanism for each drug that had a statistically significant disproportionality. METHODS: We extracted individual case safety reports of dental caries associated with drugs from VigiBase(®) (the World Health Organization global individual case safety report database)...
July 25, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28732645/sleep-deprivation-predisposes-allergic-mice-to-neutrophilic-lung-inflammation
#16
Jethe O F Nunes, Juliana de Souza Apostolico, David A G Andrade, Francieli S Ruiz, Edgar R Fernandes, Monica L Andersen, Alexandre C Keller, Daniela S Rosa
BACKGROUND: Although different studies associated sleep deprivation (SD) with systemic inflammatory changes, the effect of sleep duration on the pathology of allergic chronic diseases is poorly understood. OBJECTIVE: We sought to evaluate the influence of SD on allergen-induced pulmonary inflammation. METHODS: Ovalbumin (OVA)-sensitized C57BL/6 mice were exposed to a first set of intranasal OVA challenge under SD or healthy sleep (HS) conditions, followed by a second OVA challenge, 1 week apart...
July 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28727341/-use-of-trabecular-bone-score-as-a-complementary-approach-to-dxa-for-fracture-risk-assessment-in-clinical-practice
#17
Didier Hans, Enisa Shevroja, Olivier Lamy
Physicians can assess the risk of fracture based on bone density (BMD) and several risk factors. Some of them and BMD are incorporated into FRAX, an assessment tool that estimates the 10-years probability of fracture. BMD didn't take into account the microarchitecture. TBS is a texture parameter related to bone microarchitecture. A low TBS is associated with a history of fracture and the incidence of new fracture independently of BMD, clinical risk factors and FRAX. TBS is yet integrated in the FRAX tool, and this effect is of greatest utility for individuals who are close to an intervention threshold...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28725955/biologics-in-juvenile-idiopathic-arthritis-a-narrative-review
#18
REVIEW
Federica Vanoni, Francesca Minoia, Clara Malattia
In the past years, pediatric rheumatology has seen a revolution in the treatments for rheumatic diseases, particularly juvenile idiopathic arthritis. Even if nonsteroidal anti-inflammatory drugs (NSAID), intra-articular corticosteroids (IAC) injections, and methotrexate remain the mainstay of the treatment for JIA patients, in aggressive disease, these treatments may be not sufficient to reach disease remission and to prevent long-term disability. Comprehension of immunological mechanisms involved in the pathogenesis of the diseases allowed to conceive new drugs targeting specific steps of the immune response...
July 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28724302/efficacy-and-safety-of-vedolizumab-as-a-treatment-option-for-moderate-to-severe-refractory-ulcerative-colitis-in-two-patients-after-liver-transplant-due-to-primary-sclerosing-cholangitis
#19
Raúl Vicente Olmedo Martín, Víctor Amo Trillo, Rocío González Grande, Miguel Jiménez Pérez
Vedolizumab is a humanized IgG1 monoclonal antibody that selectively blocks the lymphocyte integrin α4β7 and prevents its interaction with endothelial adhesion molecules and subsequent transmigration to the gastrointestinal tract. The drug was approved in 2014 for the induction and maintenance treatment of ulcerative colitis and moderate to severe Crohn's disease that is refractory or intolerant to conventional treatment with corticoids and immunosuppressants and/or anti-TNFα drugs. However, inflammatory bowel disease has a variable behavior following liver transplant...
September 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28718588/-spinal-injection-risks-and-side-effects
#20
Evangelia Passia, Stéphane Genevay
The efficacy of spinal injection for chronic spinal pain is dubious for most conditions. They are however frequently prescribed. Side effects are poorly reported in the literature. In addition to benign and transient problems, serious and lethal side effects have been reported due to infection, hematoma or central and spinal cord infarctions which could be related to intravascular injection of corticoids. Although their frequency is excessively low, they should be discussed with every patient before prescription and should be mentioned in the consent form...
March 8, 2017: Revue Médicale Suisse
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