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Antinuclear antibodies

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https://www.readbyqxmd.com/read/29666638/from-localized-scleroderma-to-systemic-sclerosis-coexistence-or-possible-evolution
#1
Giuggioli Dilia, Colaci Michele, Cocchiara Emanuele, Spinella Amelia, Lumetti Federica, Ferri Clodoveo
Background: Systemic sclerosis (SSc) and localized scleroderma (LoS) are two different diseases that may share some features. We evaluated the relationship between SSc and LoS in our case series of SSc patients. Methods: We analysed the clinical records of 330 SSc patients, in order to find the eventual occurrence of both the two diseases. Results: Eight (2.4%) female patients presented both the two diagnoses in their clinical histories...
2018: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29645079/antinuclear-antibodies-in-patients-with-breast-cancer
#2
Renato Nisihara, Mariana C C Machoski, Aline Neppel, Carlos A Maestri, Iara Messias-Reason, Thelma L Skare
PURPOSE: To study the prevalence of ANA in breast cancer patients and its association with tumor characteristics. METHODS: Ninety one patients with breast mass detected by image studies and assigned to do diagnostic biopsy and eventual surgical treatment were studied for demographical, tumor data and presence of ANA. Serum of positive ANA patients was screened for ENA (extractable nuclear antigens) profile. As comparison, 91 healthy individuals matched for age and from same geographical area were included...
April 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29644928/salivary-gland-ultrasound-is-linked-to-the-autoimmunity-profile-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#3
Juan Carlos Nieto-González, Juan G Ovalles-Bonilla, Eduardo Estrada, Belén Serrano-Benavente, Julia Martínez-Barrio, Carlos M González-Fernández, Roberto González-Benítez, Cristina Vergara Dangond, Indalecio Monteagudo, Luis Collado Yurrita, Francisco Javier López-Longo
Objective Salivary gland ultrasound (SGU) is a reliable technique for assessing the salivary glands in patients with primary Sjögren's syndrome (pSS). The aim of this study was to elucidate the relationship between SGU findings and autoimmunity in patients with pSS. Methods Patients with pSS underwent an SGU assessment. The patients were classified into three groups according to their autoimmunity profile: the complete positive group (positive rheumatoid factor, antinuclear antibodies, and anti-Ro/anti-La antibodies), the partial seropositive group (positivity of at least one autoantibody but not all), and the seronegative group...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29623889/research-and-identification-of-antinuclear-antibodies-analysis-of-a-questionnaire-from-the-european-easi-group-and-confrontation-of-french-practices-to-international-recommendations
#4
Lucile Musset, Nicole Fabien, Georges Chyderiotis, Nils-Olivier Olsson, Bach-Nga Pham, Marie-Agnès Durey Dragon
Antinuclear antibodies (ANA) are prescribed as first-line autoantibodies in suspicion of mainly systemic autoimmune diseases. They include antibodies recognizing antigenic structures localized in the nucleus of cells, but also in the cytoplasm, at the membranes or transitional structures related to the cell cycle. Their research is based on screening and identification tests. For these tests, there is little or no standardization and harmonization of professional practices is necessary. From a questionnaire sent to healthcare professionals involved in the realization and interpretation of tests of autoimmunity, an overwiew of routine practices for the research of the ANA and their identification, was directed by the EASI Group International...
April 1, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29615791/autoantibody-profiling-in-lupus-patients-using-synthetic-nucleic-acids
#5
Martin Klecka, Christina Thybo, Claudia Macaubas, Ilia Solov'yov, Julia Simard, Imelda Maria Balboni, Emily Fox, Anne Voss, Elizabeth D Mellins, Kira Astakhova
Autoantibodies to nuclear components of cells (antinuclear antibodies, ANA), including DNA (a-DNA), are widely used in the diagnosis and subtyping of certain autoimmune diseases, including systemic lupus erythematosus (SLE). Despite clinical use over decades, precise, reproducible measurement of a-DNA titers remains difficult, likely due to the substantial sequence and length heterogeneity of DNA purified from natural sources. We designed and tested a panel of synthetic nucleic acid molecules composed of native deoxyribonucleotide units to measure a-DNA...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#6
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29608758/neutrophil-extracellular-trap-release-is-associated-with-antinuclear-antibodies-in-systemic-lupus-erythematosus-and-anti-phospholipid-syndrome
#7
Maarten van der Linden, Lucas L van den Hoogen, Geertje H A Westerlaken, Ruth D E Fritsch-Stork, Joël A G van Roon, Timothy R D J Radstake, Linde Meyaard
Objectives: Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. However, studies comparing NET release between patients with SLE and APS are lacking. Here we evaluated plasma-induced NET release in a large cohort of patients with SLE, SLE + APS and primary APS in relation to clinical and serological parameters. Methods: Neutrophils from healthy controls were exposed to plasma of heterologous healthy controls (n = 27) or SLE (n = 55), SLE + APS (n = 38) or primary APS (PAPS) (n = 28) patients and NET release was quantified by immunofluorescence...
March 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29602165/sonographic-evaluation-of-salivary-glands-in-juvenile-sj%C3%A3-gren-s-syndrome
#8
Vanessa Ramos Guissa, Evelyne Lopes Martinelli, Letícia Maria Kolachinski Raposo Brandão, Leandro Diniz Garcia, José Roberto Provenza, José Alexandre Mendonça
IIntroduction: Sjögren's syndrome in childhood is a rare autoimmune disease and mostly under-diagnosed. The aim of this study is to highlight the importance of ultrasonographic assessment of the salivary glands in children with recurrent parotitis and positive autoantibodies. Two cases of ultrasonographic patterns typical of Sjögren's syndrome have been described below. Case 1: Female, 7 years old, reporting for 2 years recurrent parotitis, xerophthalmia, xerostomia, polyarthralgia and fever. Immunological tests were positive for antinuclear antibodies, rheumatoid factor, anti-SSA/Ro and anti-SSB/La...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29601625/proximal-subungual-onychomycosis-in-the-immunocompetent-a-case-report-and-review-of-the-literature
#9
Sydney E Liang, David E Cohen, Evan A Rieder
Proximal subungual onychomycosis (PSO), which predominantly involves the nail plate from the proximal nail fold, is the rarest form of onychomycosis. Classically associated with an immunocompromised state, PSO is an uncommon diagnosis in individuals without immunodeficiency. We present a case of a healthy 51-year-old man, who presented with a three-month history of white discoloration of multiple toenails. Physical examination revealed white, opaque patches on the proximal third nail plates of multiple toenails...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29579355/the-role-of-ana-determinations-in-classification-criteria-for-sle
#10
David S Pisetsky, Peter E Lipsky
At present, an international group under the auspices of the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) is developing new criteria for the classification of patients with systemic lupus erythematosus (SLE) designed to be more sensitive and specific than existing criteria [1]. As discussed at the 2017 meeting of the ACR, an important feature of these criteria, which are based on a scoring system for clinical and laboratory domains, is the prominence of a positive antinuclear antibody (ANA) at a titer 1:80 or greater by immunofluorescence (IFA) as an entry criterion...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29576246/autoantibodies-targeting-tlr-and-smad-pathways-define-new-subgroups-in-systemic-lupus-erythematosus
#11
Myles J Lewis, Michael B McAndrew, Colin Wheeler, Nicholas Workman, Pooja Agashe, Jens Koopmann, Ezam Uddin, David L Morris, Lu Zou, Richard Stark, John Anson, Andrew P Cope, Timothy J Vyse
OBJECTIVES: The molecular targets of the vast majority of autoantibodies in systemic lupus erythematosus (SLE) are unknown. We set out to identify novel autoantibodies in SLE to improve diagnosis and identify subgroups of SLE individuals. METHODS: A baculovirus-insect cell expression system was used to create an advanced protein microarray with 1543 full-length human proteins expressed with a biotin carboxyl carrier protein (BCCP) folding tag, to enrich for correctly folded proteins...
March 22, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29572561/autoimmune-disorders-are-common-in-myelodysplastic-syndrome-patients-and-confer-an-adverse-impact-on-outcomes
#12
Julia Montoro, Laura Gallur, Brayan Merchán, Antonieta Molero, Elisa Roldán, Ferrán Martínez-Valle, Guillermo Villacampa, Mayda Navarrete, Margarita Ortega, Josep Castellví, Silvia Saumell, Sabela Bobillo, Francesc Bosch, David Valcárcel
The coexistence of autoimmune disorders (AD) in patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) has been widely recognized, although with distinct results regarding their prevalence and impact on the outcomes of the underlying hematological process. This study was aimed to analyze the prevalence, clinical characteristics, and outcomes of MDS with AD in a series of 142 patients diagnosed with MDS and CMML. AD was ascertained by both the presence of clinical symptoms or compatible serological tests...
March 23, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29571060/hypertrophic-spinal-pachymeningitis-associated-with-human-t-cell-lymphotrophic-virus-1-infection-and-sjogren-s-syndrome-a-case-report-and-brief-literature-review
#13
Costansia A Bureta, Masahiko Abematsu, Hiroyuki Tominaga, Yoshinobu Saitoh, Ichiro Kawamura, Satoshi Nagano, Takao Setoguchi, Yasuhiro Ishidou, Takuya Yamamoto, Setsuro Komiya
INTRODUCTION: Reports of hypertrophic spinal pachymeningitis associated with human T-cell lymphotrophic virus-1 (HTLV-1) infection and Sjogren's syndrome in the English literature are still very rare. PRESENTATION OF CASE: We hereby present a case of a 78-year-old female with a history of lower extremity weakness after a fall, which fully resolved after conservative treatment. However, the symptoms recurred 4 years later, and the patient became unable to walk. The patient had no superficial or deep sensation below the level of T9, and she also had urinary retention...
March 15, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29563108/phase-iii-trial-results-with-blisibimod-a-selective-inhibitor-of-b-cell-activating-factor-in-subjects-with-systemic-lupus-erythematosus-sle-results-from-a-randomised-double-blind-placebo-controlled-trial
#14
Joan T Merrill, William R Shanahan, Morton Scheinberg, Kenneth C Kalunian, David Wofsy, Renee S Martin
BACKGROUND: Targeted inhibitors of B-cell activating factor (BAFF) have been evaluated in phase III trials in over 4000 patients with systemic lupus erythematosus (SLE). Post hoc analyses of these studies identify greater treatment effect in patients entering with higher disease activity, greater corticosteroid doses, anti double-stranded DNA (dsDNA) and low complement C3 or C4. OBJECTIVES: To evaluate the efficacy and safety of blisibimod, a BAFF inhibitor, in a population of patients with SLE enriched for high disease activity...
March 21, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29556082/ilf2-and-ilf3-are-autoantigens-in-canine-systemic-autoimmune-disease
#15
Hanna D Bremer, Nils Landegren, Ronald Sjöberg, Åsa Hallgren, Stefanie Renneker, Erik Lattwein, Dag Leonard, Maija-Leena Eloranta, Lars Rönnblom, Gunnel Nordmark, Peter Nilsson, Göran Andersson, Inger Lilliehöök, Kerstin Lindblad-Toh, Olle Kämpe, Helene Hansson-Hamlin
Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previously described in dogs...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29535035/inflammatory-arthritis-in-pediatric-patients-with-morphea
#16
Sakeen W Kashem, Colleen K Correll, Richard K Vehe, Patricia M Hobday, Bryce A Binstadt, Sheilagh M Maguiness
BACKGROUND: Morphea, or 'localized scleroderma', is an inflammatory disorder resulting in fibrosis of the skin and subcutaneous tissues. Joint contractures, arthralgias and functional compromise are recognized associations of pediatric morphea. The co-existence of inflammatory arthritis and morphea is not well-described in the literature. OBJECTIVE: To investigate the relationship between pediatric morphea and inflammatory arthritis with regards to cutaneous, musculoskeletal and laboratory findings and treatment regimens...
March 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29534335/lupus-erythematosus-cell
#17
Armin Rashidi, Stephen I Fisher
A 24-year-old woman with a history of systemic lupus erythematosus (SLE) presented with fever, polyarthralgia, and worsened neutropenia (0.5 x 109 /L). Her physical exam and other routine laboratory work up were unremarkable. Examination of a peripheral blood smear showed neutrophils (red arrows, A-C) engulfing homogenous, violaceus nuclear material (yellow arrows, A-C), confirming a suspected diagnosis of lupus flare. SLE-associated antinuclear antibodies opsonize nucleoproteins released from dying cells, with uptake by phagocytic cells, including polymorphonuclear leukocytes and macrophages, the so-called Lupus Erythematosus (LE) cells...
March 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29531773/unique-clinical-characteristics-autoantibodies-and-medication-use-in-native-american-patients-with-systemic-lupus-erythematosus
#18
Joseph M Kheir, Carla J Guthridge, Jonathon R Johnston, Lucas J Adams, Astrid Rasmussen, Timothy F Gross, Melissa E Munroe, Rebecka L Bourn, Kathy L Sivils, Joel M Guthridge, Michael H Weisman, Daniel J Wallace, Juan-Manuel Anaya, Adriana Rojas Villarraga, James N Jarvis, John B Harley, Judith A James
Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with varied morbidity and mortality. We assessed clinical presentations, autoantibody specificities and therapeutic interventions in Native American (NA) patients with SLE. Methods: Patients with SLE meeting 1997 American College of Rheumatology classification criteria (n=3148) were enrolled between 1992 and 2010 in the multiethnic, cross-sectional Lupus Family Registry and Repository...
2018: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29526634/solid-phase-assays-versus-automated-indirect-immunofluorescence-for-detection-of-antinuclear-antibodies
#19
REVIEW
Jolien Claessens, Thibaut Belmondo, Ellen De Langhe, Rene Westhovens, Koen Poesen, Sophie Hüe, Daniel Blockmans, Michael Mahler, Marvin J Fritzler, Xavier Bossuyt
Solid phase assays (SPAs) and automated microscope systems are increasingly used to screen for antinuclear antibodies (ANAs). The goal of this study was to evaluate the performance of three automated ANA screening assays; NOVA Lite HEp-2 using NOVA View® (NV, Inova Diagnostics), an automated indirect immunofluorescence method, EliA™ CTD Screen (Fluorescence Enzyme Immunoassay, FEIA; Thermo Fisher) and QUANTA Flash® CTD Screen Plus (Chemiluminescence immunoassay, CIA; Inova Diagnostics). The assays were performed on 480 diagnostic samples from patients with an ANA-associated rheumatic disease (AARD; systemic lupus erythematosus, primary Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, mixed connective tissue disease) and on 767 samples from diseased and healthy controls...
March 8, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29526309/primary-biliary-cholangitis
#20
REVIEW
Albert Parés
Primary cholangitis (cirrhosis) is a chronic cholestatic disease with an unquestionable female predominance. It is characterised by inflammation of the small and medium size bile ducts, and can eventually progress to cirrhosis. Most patients remain asymptomatic and are diagnosed by the casual finding of an anicteric biochemical cholestasis with increased alkaline phosphatase. The pathogenesis is unknown and of presumed autoimmune origin in genetic susceptible subjects. M2-type antimitochondrial antibodies, and specific antinuclear antibodies (gp210 and Sp100) are typical and specific of the disease...
March 8, 2018: Medicina Clínica
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