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Adenoma detection rate

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https://www.readbyqxmd.com/read/28224298/the-performance-of-the-msept9-assay-is-influenced-by-algorithm-cancer-stage-and-age-but-not-sex-and-cancer-location
#1
Lele Song, Jia Jia, Haotian Yu, Xiumei Peng, Wenhua Xiao, Yuan Gong, Guangpeng Zhou, Xiaoliang Han, Yuemin Li
PURPOSE: This study aims to examine the influence of algorithm and subject-related factors, including cancer stage, age, sex, and cancer location, on the performance of the SEPT9 gene methylation test, an assay approved by the US FDA for colorectal cancer (CRC) screening. METHODS: A total of 1225 subjects were recruited in this opportunistic screening study, including 388 CRC patients, 139 subjects with adenoma, 108 subjects with hyperplastic polyps, and 590 subjects with no evidence of disease (NED)...
February 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28218734/-lesions-detected-in-six-spanish-colorectal-cancer-screening-population-based-programmes-cribea-project-spain
#2
Isabel Portillo Villares, Eunate Arana-Arri, Isabel Idigoras Rubio, Josep Alfons Espinás Piñol, Francisco Pérez Riquelme, Mariola de la Vega Prieto, Alvaro González Aledo, Elena Oceja Setien, Mercedes Vanaclocha Espi, Josefa Ibáñez Cabanell, Dolores Salas Trejo
OBJECTIVE: In this study, the results of six Colorectal Cancer Screening Population Programmes are shown (Catalonia, Valence, Murcia, Cantabria, the Basque Country and the Canary Islands collected between 2005 and 2012. These programmes use the faeces occult blood test (FOBt) biennial. Objective: To determine and compare the results of lesions detected by the programmes, participation, sex, age and test used. METHODS: Retrospective cohort study based on people invited, aged between 50-74 years, in at least a complete round...
February 20, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28215770/does-endoscopist-fatigue-impact-adenoma-detection-rate-a%C3%A2-review-of-the-evidence-to-date
#3
EDITORIAL
Christopher V Almario, Brennan M R Spiegel
No abstract text is available yet for this article.
March 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28215769/quality-metrics-beyond-adenoma-detection-rate
#4
EDITORIAL
Brian R Weston, William A Ross
No abstract text is available yet for this article.
March 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28205108/water-assisted-colonoscopy
#5
REVIEW
Sergio Cadoni, Felix W Leung
The current review will attempt to describe the important lessons learned from published randomized controlled trials (RCT) comparing water immersion (WI) or water exchange (WE) techniques with gas insufflation colonoscopy. Air insufflation (AI) to distend the colon to permit visualization and passage through the lumen was developed for diagnostic colonoscopy. When screening colonoscopy was adopted, the same AI method was used. Interval cancers, diagnosed within 3 to 5 years after an index screening colonoscopy, appeared to be linked to low adenoma detection rate (ADR)...
February 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28193491/linked-color-imaging-improves-endoscopic-visibility-of-colorectal-nongranular-flat-lesions
#6
Takuto Suzuki, Taro Hara, Yoshiyasu Kitagawa, Hideyuki Takashiro, Rino Nankinzan, Osamu Sugita, Taketo Yamaguchi
BACKGROUND AND AIMS: As a newly developed image-enhanced endoscopy (IEE) technique, linked-color imaging (LCI) provides very bright images with enhanced color tones. With the objective of improving the detection rate of colorectal flat tumor lesions, which are difficult to detect, we examined the usefulness of LCI from the viewpoint of visibility. METHODS: Fifty-three consecutive nongranular flat tumors were used in this study. Endoscopic images were acquired by white-light imaging (WLI), blue-laser imaging (BLI)-bright, and LCI modes...
February 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28192245/feasibility-and-safety-of-minimally-invasive-radioguided-parathyroidectomy-using-very-low-intraoperative-dose-of-tc-99m-mibi
#7
Mostafa Mehrabibahar, Zohreh Mousavi, Ramin Sadeghi, Parvin Layegh, Masoumeh Nouri, Mehdi Asadi
BACKGROUND: Surgical resection of the abnormal parathyroid glands is the only curative treatment for primary hyperparathyroidism (PHPT). Radioguided parathyroidectomy with technetium-99m (TC-99m) sestamibi has been successfully used in patients with PHPT. This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis...
February 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28182068/evaluation-of-thyroid-nodules-classified-as-bethesda-category-iii-on-fnac
#8
Shiwani Garg, Leena P Naik, Kanchan S Kothari, Gwendolyn C Fernandes, Mona A Agnihotri, Jagruti C Gokhale
BACKGROUND: The Bethesda (BSRTC) category III has been ascribed a malignancy rate of 5-15%, however, the probability of malignancy remains variable. AIM: To evaluate category III with respect to its rate and risk of malignancy and substratify it. SETTINGS AND DESIGN: Atypia of undetermined significance/Follicular lesion of undetermined significance (AUS/FLUS) percentage, cytohistological correlation, and risk of malignancy were analyzed and substratification was done...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28173773/colorectal-cancer-surveillance-in-hodgkin-lymphoma-survivors-at-increased-risk-of-therapy-related-colorectal-cancer-study-design
#9
Lisanne S Rigter, Manon C W Spaander, Leon M Moons, Tanya M Bisseling, Berthe M P Aleman, Jan Paul de Boer, Pieternella J Lugtenburg, Cecile P M Janus, Eefke J Petersen, Judith M Roesink, John M M Raemaekers, Richard W M van der Maazen, Annemieke Cats, Eveline M A Bleiker, Petur Snaebjornsson, Beatriz Carvalho, Iris Lansdorp-Vogelaar, Katarzyna Jóźwiak, Hein Te Riele, Gerrit A Meijer, Flora E van Leeuwen, Monique E van Leerdam
BACKGROUND: Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine have an increased risk to develop colorectal cancer. Colonoscopy surveillance plays an important role in colorectal cancer prevention by removal of the precursor lesions (adenomas) and early detection of cancer, resulting in improved survival rates. Therefore, Hodgkin lymphoma survivors treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine could benefit from colonoscopy, or other surveillance modalities, which are expected to reduce colorectal cancer incidence and mortality...
February 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28173666/-hbxip-expression-in-gastric-adenocarcinoma-predicts-poor-prognosis
#10
J J Piao, N Li, Y X Wang, Z H Lin, S P Liu
Objective: To investigate the localization of HBXIP protein over-expression in gastric adenocarcinoma, and its prognostic significance. Methods: HBXIP localization was detected by immunofluorescence in AGS gastric cancer cell line, and by immunohistochemical staining in 97 gastric adenocarcinomas, 41 adjacent non-tumor tissues and 13 gastric adenoma tissues. Correlation between HBXIP expression and clinicopathological features of gastric cancer patients was evaluated by Chi-square and Fisher's exact tests. Overall survival rates were calculated using Kaplan-Meier method...
February 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28153571/providing-data-for-serrated-polyp-detection-rate-benchmarks-an-analysis-of-the-new-hampshire-colonoscopy-registry
#11
Joseph C Anderson, Lynn F Butterly, Julia E Weiss, Christina M Robinson
BACKGROUND AND AIMS: Similar to achieving adenoma detection rate (ADR) benchmarks to prevent colorectal cancer (CRC), achieving adequate serrated polyp detection rates (SDR) may be essential to the prevention of CRC associated with the serrated pathway. Previous studies have been based on data from high-volume endoscopists at single academic centers. Based on a hypothesis that ADR is correlated with SDR, we stratified a large, diverse group of endoscopists (n=77 practicing at 28 centers) into high and low performers based on ADR, to provide data for corresponding target SDR benchmarks...
January 30, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28152558/strong-subsite-specific-variation-in-detecting-advanced-adenomas-by-fecal-immunochemical-testing-for-hemoglobin
#12
Hermann Brenner, Tobias Niedermaier, Hongda Chen
Fecal immunochemical tests (FITs) for hemoglobin are increasingly recommended and used in colorectal cancer (CRC) screening. We aimed to provide a detailed assessment of the sensitivity of FIT according to type and subsite of neoplasms in a true screening setting. A quantitative FIT (FOB Gold, Sentinel Diagnostics, Milano, Italy) was applied prior to colonoscopy by 3466 participants of the German screening colonoscopy program. Subsite specific sensitivity for various types of colorectal neoplasms was derived by comparing FIT results with findings at screening colonoscopy...
February 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28147226/detectability-of-colorectal-neoplastic-lesions-using-a-novel-endoscopic-system-with-blue-laser-imaging-a-multicenter-randomized-controlled-trial
#13
Hiroaki Ikematsu, Taku Sakamoto, Kazutomo Togashi, Naohisa Yoshida, Takashi Hisabe, Shinsuke Kiriyama, Koji Matsuda, Yoshikazu Hayashi, Takahisa Matsuda, Shozo Osera, Kazuhiro Kaneko, Kenichi Utano, Yuji Naito, Hiroshi Ishihara, Masayuki Kato, Kenichi Yoshimura, Hideki Ishikawa, Hironori Yamamoto, Yutaka Saito
BACKGROUND & AIM: Most studies have not reported an improvement in the detection of adenoma with the use of image-enhanced colonoscopy methods, possibly due to the darkness of the images. To overcome this limitation, a new-generation endoscopic system has been developed. This system has 2 blue-laser imaging (BLI) observation modes. The BLI observation was set to BLI-bright mode to detect lesions. We aimed to evaluate the efficacy of BLI in detecting lesions. METHODS: This study was designed as a randomized controlled trial with participants from 8 institutions...
January 29, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28139497/the-expression-and-significance-of-feces-cyclooxygensae-2-mrna-in-colorectal-cancer-and-colorectal-adenomas
#14
Xiaofeng Li, Lixia Kong, Suhuan Liao, Jing Lu, Lin Ma, Xiaohua Long
BACKGROUND/AIM: This study aims to explore the expression and significance of feces cyclooxygensae-2 (COX-2) mRNA in colorectal cancer and colorectal adenomas. MATERIALS AND METHODS: The expression of feces COX-2 mRNA in colorectal cancer (n = 28), colorectal adenomas (n = 54), and normal control group (n = 11) were examined by reverse transcriptase polymerase chain reaction (RT-PCR). The positive rate of fecal occult blood test (FOBT) were detected in colorectal cancer (n = 30), colorectal adenomas (n = 56), and normal control group (n = 11); the sensitivity of the two methods was also compared...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28138858/strategies-to-increase-adenoma-detection-rates
#15
REVIEW
Eelco C Brand, Michael B Wallace
The adenoma detection rate (ADR), i.e., the proportion of average risk patients with at least one adenoma detected during screening colonoscopy, is inversely associated with the development of interval colorectal cancer. Increasing the ADR is therefore an important proxy for increase in quality and efficacy of (screening) colonoscopy. Several potentially modifiable factors, such as, procedural and technological factors, and quality improvement programs, and their effect on the ADR will be reviewed. Procedural factors, such as, bowel preparation, withdrawal time, and position changes of the patient are associated with the ADR...
January 30, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28137551/bromocriptine-induces-autophagy-dependent-cell-death-in-pituitary-adenomas
#16
Xin Geng, Lixin Ma, Zefu Li, Zhenzhu Li, Jianmin Li, Meng Li, Qingbo Wang, Zheng Chen, Qikai Sun
BACKGROUND: Bromocriptine(BRC) is effective in patients with prolactinoma. However, the cytotoxic mechanism of BRC remains unknown. METHODS: Slices for immunohistochemical pathology were randomly selected from 37 paraffin-embedded prolactinoma tissue sections. LC3 was detected by immunohistochemistry. GH3 and MMQ cells were treated by BRC and/or rapamycin (RAPA). Cell viability and the cell cycle were measured by CCK-8 and flow cytometry, respectively. ELISA measured prolactin secretion...
January 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28129661/efficacy-of-segmental-re-examination-of-proximal-colon-for-adenoma-detection-during-colonoscopy-a-randomized-controlled-trial
#17
Chuan-Guo Guo, Feifei Zhang, Rui Ji, Yueyue Li, Lixiang Li, Xiu-Li Zuo, Yan-Qing Li
: Background and study aims Interval colorectal cancers detected after screening colonoscopy are more likely to be associated with missed lesions in the proximal colon. The aim of this study was to determine whether segmental re-examination of the proximal colon could increase the proximal adenoma detection rate (ADR) and to evaluate the time-effectiveness of this approach. Patients and methods Patients undergoing colonoscopy were recruited into the prospective randomized controlled study...
January 27, 2017: Endoscopy
https://www.readbyqxmd.com/read/28125785/ct-colonographic-screening-of-patients-with-a-family-history-of-colorectal-cancer-comparison-with-adults-at-average-risk-and-implications-for-guidelines
#18
Perry J Pickhardt, Ifeanyi Mbah, B Dustin Pooler, Oliver T Chen, J Louis Hinshaw, Jennifer M Weiss, David H Kim
OBJECTIVE: The purposes of this study were to compare rates of lesion detection at CT colonographic (CTC) screening of adults without symptoms who had and who did not have a family history of colorectal cancer according to American Cancer Society guidelines and to consider the clinical implications. MATERIALS AND METHODS: Over 134 months, consecutively registered CTC cohorts of adults without symptoms who had (n = 156; 88 [56.4%] women; 68 [43.6%] men; mean age, 56...
January 26, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28123705/the-diagnostic-effect-of-serum-mir-196b-as-biomarker-in-colorectal-cancer
#19
Chunjie Xu, Lei Gu
The microRNA, miR-196b, serves a role in normal cell differentiation, proliferation and tumorigenesis of different types of cancer. The aim of the present study was to explore the serum expression of miR-196b in colorectal cancer (CRC) and its correlation with clinicopathological features. Sera samples were obtained from 103 patients with CRC, 51 patients with colorectal adenoma (Ad) and 100 healthy individuals for the present study. The serum expression of miR-196b in sera samples of the three cohorts was detected using reverse transcription-quantitative polymerase chain reaction...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28117881/comparative-effectiveness-of-screening-strategies-for-colorectal-cancer
#20
Afsaneh Barzi, Heinz-Josef Lenz, David I Quinn, Sarmad Sadeghi
BACKGROUND: Screening for colorectal cancer (CRC) has been successful in decreasing the incidence and mortality from CRC. Although new screening tests have become available, their relative impact on CRC outcomes remains unexplored. This study compares the outcomes of various screening strategies on CRC outcomes. METHODS: A Markov model representing the natural history of CRC was built and validated against empiric data from screening trials as well as the Microstimulation Screening Analysis (MISCAN) model...
January 24, 2017: Cancer
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