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Adenoma detection rate

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https://www.readbyqxmd.com/read/28072975/-molecular-features-of-metanephric-adenoma-and-their-values-in-differential-diagnosis
#1
X Wang, S S Shi, W R Yang, S B Ye, R Li, H H Ma, R S Zhang, Z F Lu, X J Zhou, Q Rao
Objective: To study the molecular features of metanephric adenoma (MA) and discuss their values in differential diagnosis. Methods: BRAF V600E immunohistochemistry (IHC) using the mutation-specific VE1 monoclonal antibody and Sanger sequencing of BRAF mutations were performed on 21 MAs, 16 epithelial-predominant Wilms tumors (e-WT) and 20 the solid variant of papillary renal cell carcinomas (s-PRCC) respectively. p16 protein was detected by IHC also. Fluorescence in situ hybridization (FISH) analyses using centromeric probes for chromosome 7 and 17 were performed on the three renal tumors in parallel...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28070476/evaluating-screening-colonoscopy-quality-in-an-uninsured-urban-population-following-patient-navigation
#2
Keith Naylor, Cassandra Fritz, Blase Polite, Karen Kim
Patient navigation (PN) increases screening colonoscopy completion in minority and uninsured populations. However, colonoscopy quality is under-reported in the setting of PN and quality indicators have often failed to meet benchmark standards. This study investigated screening colonoscopy quality indicators after year-one of a PN initiative targeting the medically uninsured. This was a retrospective analysis of 296 outpatient screening colonoscopies. Patients were 45 to 75 years of age with no history of bowel cancer, inflammatory bowel disease, or colorectal surgery...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28069476/missed-adenomas-with-behind-folds-visualizing-colonoscopy-technologies-compared-with-standard-colonoscopy-a-pooled-analysis-of-3-randomized-back-to-back-tandem-colonoscopy-studies
#3
Eelco C Brand, Vincent K Dik, Martijn G H van Oijen, Peter D Siersema
BACKGROUND AND AIMS: The Third Eye Retroscope, Full Spectrum Endoscope (FUSE) and EndoRings device have been shown to reduce overall adenoma miss rates. We evaluated the characteristics of adenomas and patient subgroups for which these "behind folds visualizing" technologies mostly reduce adenoma miss rates. METHODS: Data of 3 multicenter randomized trials (NCT01044732; NCT01549535; NCT01955122) were combined. Patients underwent same-day, back-to-back tandem examinations with standard colonoscopy and Third Eye Retroscope, FUSE or EndoRings colonoscopy, respectively...
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28059941/adenoma-detection-rates-for-screening-colonoscopies-in-smokers-and-obese-adults-data-from-the-new-hampshire-colonoscopy-registry
#4
Joseph C Anderson, Julia E Weiss, Christina M Robinson, Lynn F Butterly
GOAL: To examine screening adenoma detection rates (ADR) and serrated detection rates (SDR) among smokers and obese adults in the New Hampshire Colonoscopy Registry. BACKGROUND: ADR, a quality measure for screening colonoscopies, is associated with protection from interval colorectal cancer. Currently, only sex-specific ADR benchmarks are reported. However, obesity and smoking ≥20 pack-years are strong predictors for colorectal neoplasia, as highlighted by the 2009 American College of Gastroenterology CRC Screening Guidelines...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28056302/-expression-of-cd10-in-cancer-associated-fibroblasts-and-its-effect-on-initiation-and-progression-of-colorectal-carcinoma
#5
Y Zhu, J J Zheng, F Yang, Q Q Nie, Z L Zhu, H Deng
Objective: To study CD10 expression in cancer-associated fibroblasts (CAF) and related effect on colorectal cancer initiation and progression. Methods: A total of 226 surgical removed colorectal cancer specimens were collected with patient follow-up data. A panel of immunohistochemical markers(CD10, Ki-67, p53, cyclin D1 and β-catenin) were evaluated in carcinomas, adjacent adenomas and paired normal colorectal mucosa with correlation of clinicopathological parameters. Results: CD10 expression was not detected in the normal colorectal mucosa by immunohistochemistry...
December 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28035253/colon-adenoma-features-and-their-impact-on-risk-of-future-advanced-adenomas-and-colorectal-cancer
#6
Audrey H Calderwood, Karen E Lasser, Hemant K Roy
AIM: To review the evidence on the association between specific colon adenoma features and the risk of future colonic neoplasia [adenomas and colorectal cancer (CRC)]. METHODS: We performed a literature search using the National Library of Medicine through PubMed from 1/1/2003 to 5/30/2015. Specific Medical Subject Headings terms (colon, colon polyps, adenomatous polyps, epidemiology, natural history, growth, cancer screening, colonoscopy, CRC) were used in conjunction with subject headings/key words (surveillance, adenoma surveillance, polypectomy surveillance, and serrated adenoma)...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28025471/-new-colonoscopy-devices-to-improve-colon-neoplasm-detection
#7
REVIEW
Sung Jae Shin
Early detection and removal of adenomatous polyps can prevent the development of colorectal cancer. However, it is fairly common-up to 20%-for polyps to be undetected in a colonoscopy due to poor visualization of the proximal aspect of colonic folds and anatomical flexures. To overcome these limitations, many new endoscopes and accessories have been developed. A wide-angle colonoscopy did not improve the detection of adenoma compared with the standard colonoscopy. An extra-wide angle and Retroview colonoscopies showed a significantly lower miss rate of polyps in the colon model...
December 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28024986/the-natural-history-of-diminutive-and-small-colorectal-polyps-a-systematic-literature-review
#8
REVIEW
Jasper L A Vleugels, Yark Hazewinkel, Paul Fockens, Evelien Dekker
BACKGROUND: Diminutive (1-5 mm) and small (6-9 mm) polyps comprise 90% of detected lesions during colonoscopy and rarely contain advanced histology or colorectal cancer (CRC). Routine removal of these lesions results in a significant burden to colonoscopy programs. At the same time, the risk for progression of these polyps to CRC is unclear. We performed a systematic review to explore the natural history of diminutive and small colorectal polyps. METHODS: We searched MEDLINE and EMBASE for studies investigating the natural history of colorectal polyps...
December 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28019112/-indications-diagnoses-and-quality-markers-in-upper-and-lower-endoscopies-in-2010-and-2011-at-the-1st-department-of-medicine-semmelweis-university-budapest
#9
Lóránt Gönczi, Zsuzsanna Kürti, Petra Golovics, Zsuzsanna Végh, Barbara Lovász, Andrea Dorkó, Anna Seres, Liza Sümegi, Orsolya Menyhárt, Lajos Kiss, János Papp, Krisztina Gecse, Péter László Lakatos
INTRODUCTION AND AIM: The aim was to assess the incidence of endoscopic findings based on the indication of the procedures in upper/lower endoscopies, and measuring quality indicators of colonoscopies at the 1st Department of Medicine, Semmelweis University, Budapest. METHOD: Data of 2987 patients (male/female:1361/1626, mean age: 60.7 years(y), SD: 16.7y) between 01.01.2010 and 31.12.2011 were analyzed. Both inpatient and outpatient records were collected. RESULTS: Incidence of peptic ulcer disease, esophageal varices, gastric polyps and gastric cancer were 10...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/28018111/clinical-features-of-upper-gastrointestinal-serrated-lesions-an-endoscopy-database-analysis-of-98746-patients
#10
Hai-Long Cao, Wen-Xiao Dong, Meng-Que Xu, Yu-Jie Zhang, Si-Nan Wang, Mei-Yu Piao, Xiao-Cang Cao, Bang-Mao Wang
AIM: To analyse the clinical features of patients with the serrated lesions in the upper gastrointestinal tract (UPGI) tract. METHODS: Patients who underwent routine esophagogastroduodenoscopy (EGD) at the Digestive Endoscopy Centre of General Hospital, Tianjin Medical University between January 2011 and December 2015 were consecutively recruited. Patients with UPGI serrated lesions were consecutively identified. The patients' demographics and histopathology were recorded...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28018109/clinical-implications-of-doubling-time-of-gastrointestinal-submucosal-tumors
#11
Shuko Koizumi, Mitsuhiro Kida, Hiroshi Yamauchi, Kosuke Okuwaki, Tomohisa Iwai, Shiro Miyazawa, Miyoko Takezawa, Hiroshi Imaizumi, Wasaburo Koizumi
AIM: To evaluate the efficacy of doubling time (DT) of gastrointestinal submucosal tumors (GIST). METHODS: From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients (34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28000629/effectiveness-of-contrast-enhanced-endoscopic-ultrasound-for-detecting-mural-nodules-in-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-and-for-making-therapeutic-decisions
#12
Mitsuru Fujita, Takao Itoi, Nobuhito Ikeuchi, Atsushi Sofuni, Takayoshi Tsuchiya, Kentaro Ishii, Kentaro Kamada, Junko Umeda, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Fuminori Moriyasu
BACKGROUND AND OBJECTIVES: There have been few studies to date evaluating the effectiveness of contrast-enhanced endoscopic ultrasound (CE-EUS) for detecting mural nodules in patients with branch duct-type intraductal papillary mucinous neoplasm (BD-IPMN) of the pancreas. We aim to evaluate the effectiveness of CE-EUS for detecting mural nodules in BD-IPMN. PATIENTS AND METHODS: Of the 427 BD-IPMN patients, 21 patients (4.9%) in whom the presence of mural nodules was suggested by CE computed tomography (CT) or magnetic resonance imaging (MRI), or in whom the presence of nodule-like lesions as shown by fundamental EUS, were examined by CE-EUS...
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27997965/improving-uptake-of-flexible-sigmoidoscopy-screening-a-randomized-trial-of-nonparticipant-reminders-in-the-english-screening-programme
#13
Robert S Kerrison, Lesley M McGregor, Sarah Marshall, John Isitt, Nicholas Counsell, Colin J Rees, Christian von Wagner
Background and study aims Uptake of flexible sigmoidoscopy screening in the English Bowel Scope Screening (BSS) Programme is low. The aim of this study was to test the impact of a nonparticipant reminder and theory-based leaflet to promote uptake among former nonresponders (previously did not confirm their appointment) and nonattenders (previously confirmed their appointment but did not attend). Patients and methods Eligible adults were men and women in London who had not attended a BSS appointment within 12 months of their invitation...
January 2017: Endoscopy
https://www.readbyqxmd.com/read/27995405/comparison-of-colonoscopy-quality-measures-across-various-practice-settings-and-the-impact-of-performance-scorecards
#14
Jennifer A Inra, Jennifer Nayor, Margery Rosenblatt, Muthoka Mutinga, Sarathchandra I Reddy, Sapna Syngal, Fay Kastrinos
BACKGROUND: Quality performance measures for screening colonoscopy vary among endoscopists. The impact of practice setting is unknown. AIMS: We aimed to (1) compare screening colonoscopy performance measures among three different US practice settings; (2) evaluate factors associated with adenoma detection; and (3) assess a scorecard intervention on performance metrics. METHODS: This multi-center prospective study compared patient, endoscopist, and colonoscopy characteristics performed at a tertiary care hospital (TCH), community-based hospital (CBH), and private practice group (PPG)...
December 19, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27995188/does-carbon-dioxide-insufflation-impact-adenoma-detection-rate-a-single-center-retrospective-analysis
#15
Yaseen B Perbtani, Michael Riverso, Jonathan J Shuster, Joydeep Chakraborty, Tony S Brar, Mitali Agarwal, Han Zhang, Anand Gupte, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov, Dennis Yang
Background and study aims: Carbon dioxide (CO2) has been associated with reduced post-procedural pain and improved patient satisfaction when compared to air insufflation (AI). The effect of CO2 insufflation (CO2I) on the adenoma detection rate (ADR) remains unclear. The aims of this study are to compare ADR in patients undergoing screening colonoscopy with AI vs. CO2I and identify predictors of ADR. Patients and methods: Single-center retrospective cohort study of 2,107 patients undergoing screening colonoscopy at the University of Florida Hospital between November 2011 and June 2015...
December 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27994617/preliminary-experience-using-full-spectrum-endoscopy-for-colorectal-cancer-screening-matched-case-controlled-study
#16
Sayo Ito, Kinichi Hotta, Kenichiro Imai, Masao Yoshida, Kimihiro Igarashi, Yuichiro Yamaguchi, Kohei Takizawa, Naomi Kakushima, Masaki Tanaka, Noboru Kawata, Hiroyuki Matsubayashi, Hirotoshi Ishiwatari, Hiroyuki Ono
Background/Aim. High-quality colonoscopy is needed to reduce the morbidity and mortality of colorectal cancer. Full-spectrum endoscopy (FUSE) has recently shown potential in improving adenoma detection during colonoscopy. This study aimed to evaluate the feasibility and utility of FUSE colonoscopy. Methods. From April 2015 to February 2016, 130 patients underwent FUSE colonoscopy for screening at a tertiary cancer center. Cecal intubation rate (CIR), procedure time, polyp/adenoma detection rate (PDR/ADR), and mean number of adenomas per colonoscopy (APC) were compared in matched-control patients (n = 260) who underwent standard colonoscopy (SC)...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27988288/prospective-multicenter-randomized-controlled-trial-comparing-adenoma-detection-rate-in-colonoscopy-using-water-exchange-water-immersion-and-air-insufflation
#17
Yu-Hsi Hsieh, Chih-Wei Tseng, Chi-Tan Hu, Malcolm Koo, Felix W Leung
BACKGROUND AND AIMS: Adenoma detection rate (ADR) is a quality indicator. We tested the hypothesis that water exchange (WE) improves whereas water immersion (WI) has no adverse effect on ADR compared with air insufflation (AI). METHODS: A prospective study (NCT01894191) was conducted at the Dalin Tzu Chi Hospital in southern Taiwan and the Hualien Tzu Chi Hospital in eastern Taiwan on patients randomly assigned to WE, WI, or AI with stratification by the 3 study colonoscopists...
December 14, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27976552/parotidectomy-outcomes-diagnosis-and-complications-on-pediatric-patients-twelve-years-of-experiences-in-a-tertiary-care-center
#18
Oğuz Kuşcu, Bahar Kayahan, Övsen Önay, Rıza Önder Günaydın, Mehmet Umut Akyol
The aim of this study is to evaluate parotid masses management in pediatric population. From June 2002 to December 2014, 13 patients under the age of 18 with parotid tumors were treated via surgery at Hacettepe University Department of Otorhinolaryngology. Information on patients' demographics, clinical and histopathologic tumor characteristics and treatment modalities with results was obtained from medical records, retrospectively. The age was ranging between 8-17 years. Ten (76.9%) patients had benign tumors and 8 (61...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27974550/a-comparative-effectiveness-trial-of-two-faecal-immunochemical-tests-for-haemoglobin-fit-assessment-of-test-performance-and-adherence-in-a-single-round-of-a-population-based-screening-programme-for-colorectal-cancer
#19
Basilio Passamonti, Morena Malaspina, Callum G Fraser, Beatrice Tintori, Angela Carlani, Valentina D'Angelo, Paola Galeazzi, Eugenio Di Dato, Loretta Mariotti, Simonetta Bulletti, Maria Rosaria D'Amico, Daniela Gustinucci, Nadia Martinelli, Nicoletta Spita, Elena Cesarini, Tiziana Rubeca, Mariadonata Giaimo, Nereo Segnan, Carlo Senore
AIM: To compare acceptability and diagnostic accuracy of a recently available faecal immunochemical test (FIT) system (HM-JACKarc) with the FIT routinely used in an established screening programme (OC-Sensor). DESIGN: Randomised controlled trial (ISRCTN20086618) within a population-based colorectal cancer (CRC) screening programme. Subjects eligible for invitation in the Umbria Region (Italy) programme were randomised (ratio 1:1) to be screened using one of the FIT systems...
December 14, 2016: Gut
https://www.readbyqxmd.com/read/27931951/adenoma-miss-rates-associated-with-a-3-minute-versus-6-minute-colonoscopy-withdrawal-time-a-prospective-randomized-trial
#20
Sheila Kumar, Nirav Thosani, Uri Ladabaum, Shai Friedland, Ann M Chen, Rajan Kochar, Subhas Banerjee
BACKGROUND AND AIMS: The 6-minute withdrawal time for colonoscopy, widely considered the standard of care is controversial; the skill and technique of endoscopists may be as important, or more important than withdrawal time, for adenoma detection. It is unclear whether a shorter withdrawal time with good technique yields an acceptable lesion detection rate. Our objective was to evaluate a 3-minute versus a 6-minute withdrawal time using segmental tandem colonoscopy. METHODS: We performed a prospective, randomized trial using 4 expert endoscopists...
December 5, 2016: Gastrointestinal Endoscopy
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