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Adenoma detection rate

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https://www.readbyqxmd.com/read/28328936/polyp-detection-rate-in-transverse-and-sigmoid-colon-significantly-increases-with-longer-withdrawal-time-during-screening-colonoscopy
#1
Kazuhiro Kashiwagi, Nagamu Inoue, Toshifumi Yoshida, Rieko Bessyo, Kazuaki Yoneno, Hiroyuki Imaeda, Haruhiko Ogata, Takanori Kanai, Yoshinori Sugino, Yasushi Iwao
BACKGROUND: The guidelines for colonoscopy present withdrawal time (WT) and adenoma detection rate (ADR) as the quality indicator. The purpose of this retrospective study is to analyze the predicting factors with polyp detection rate (PDR) as a surrogate for ADR by using comprehensive health checkup data, and assess the correlation between PDR per each colonic segment and WT, and factors influencing WT. METHODS: One thousand and thirty six consecutive health checkup cases from April 2015 to March 2016 were enrolled in this study, and 880 subjects who undertook colonoscopy without polyp removal or biopsy were divided into the two groups (polyp not detected group vs polyp detected group)...
2017: PloS One
https://www.readbyqxmd.com/read/28326706/-clinical-efficacy-of-the-fine-needle-aspiration-of-the-cell-block-in-the-diagnosis-of-parotid-gland-masses
#2
Chen Hong, Fang Qingquan, Tu Jinhua, Cai Qiaoling, Zhang Suhua
OBJECTIVE: To investigate the clinical significance of cell blocks obtained by ultrasound-guided fine needle aspiration in diagnosing parotid gland masses. METHODS: Cell blocks were made in 285 parotid gland masses by ultrasound-guided fine needle aspiration. Diagnosis was conducted using the cell blocks. Non-tumor masses were subjected to conservative treatment, and cysts and tumors were treated with surgery. The cell block sections from masses with the diagnosis of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) were applied to the detection of immunocytochemical staining for the stem cell factor receptor CD117...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28319429/current-standards-and-new-developments-of-colorectal-polyp-management-and-resection-techniques
#3
Daniel von Renteln, Mickael Bouin, Alan N Barkun
Colonoscopy and endoscopic removal of precancerous polyps play an important role in colorectal cancer (CRC) prevention. Improved endoscopes and quality standards have led to an increasing polyp and adenoma detection rate. Optimal polyp resection techniques and management strategies are key for an effective colonoscopy practice. Areas covered: Strategies for how to improve diminutive polyp (polyps up to 5mm in size) management are discussed because of their high prevalence. Systematic removal of diminutive polyps leads to increasing costs of colonoscopy practice, while the effect on colorectal cancer prevention might be negligible...
March 20, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28317624/cap-assisted-colonoscopy-increases-detection-of-advanced-adenomas-and-polyps
#4
Mohamed O Othman, Daniel Zhang, Sherif Elhanafi, Mohamed Eloliby, Brian Davis, Richard Guererro, Luis Alvarado, Linda Sanchez, Alok Dwivedi, Marc J Zuckerman
BACKGROUND: Cap-assisted colonoscopy (CAC) has been reported to increase the adenoma detection rate (ADR) in Asian population. However, CAC trials in non-Asian population have had conflicting results. Studies in North America have shown an improvement in ADRs with the use of CAC, but it mainly included white and African American patients. Given the lack of prospective studies of CAC in Hispanics, we conducted this randomized controlled trial. MATERIALS AND METHODS: This is a randomized controlled trial comparing CAC with standard colonoscopy (SC) in patients undergoing screening or surveillance colonoscopy...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28293023/advances-in-image-enhancement-in-colonoscopy-for-detection-of-adenomas
#5
REVIEW
Takahisa Matsuda, Akiko Ono, Masau Sekiguchi, Takahiro Fujii, Yutaka Saito
High-quality colonoscopy is mandatory to prevent adenoma recurrence and colorectal cancer. In the past few years, technical advances have been developed with the purpose of improving adenoma detection rate (ADR), one of the most important validated colonoscopy quality benchmarks. Several techniques or devices are used to optimize visualization: observation techniques; add-on devices; auxiliary imaging devices; colonoscopes with increased field of view; and colonoscopes with an integrated inflatable reusable balloon...
March 15, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28286095/comparison-of-linked-color-imaging-and-white-light-colonoscopy-for-colorectal-polyp-detection-a-multicenter-randomized-crossover-trial
#6
Min Min, Pei Deng, Wenhua Zhang, Xiaomin Sun, Yan Liu, Bing Nong
BACKGROUND AND AIMS: Linked color imaging (LCI) is a recently developed technology that uses a laser endoscopic system to enhance the color separation of red color to depict red and white colors more vividly. The benefits of LCI in colorectal polyp detection remain unknown. The aim of this study was to assess the ability of LCI to increase colorectal polyp detection compared to white-light (WL) endoscopy. METHODS: We performed a multicenter, crossover, prospective, randomized controlled trial in three hospitals in China...
March 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28284112/prognosis-of-pituitary-adenomas-in-the-early-1970s-and-today-is-there-a-benefit-of-modern-surgical-techniques-and-treatment-modalities
#7
Stefan Linsler, Friedericke Quack, Karsten Schwerdtfeger, Joachim Oertel
OBJECTIVE: Neurosurgical techniques for the treatment of sellar pathologies have been evolving continuously over the last decades. Additionally to the innovation of approaches and surgical techniques, this progress yielded to the application of modern intraoperative surgical tools as well as peri- and intraoperative imaging. Until now, no long-term analysis of the impact of new therapy concepts on the patient's outcome exists. Aim of this study was to analyse the impact of new operative approaches on perioperative mortality and morbidity as well as the long-term outcome after pituitary surgery...
March 2, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28282689/water-exchange-for-screening-colonoscopy-increases-adenoma-detection-rate-a-multicenter-double-blinded-randomized-controlled-trial
#8
Sergio Cadoni, Přemysl Falt, Emanuele Rondonotti, Franco Radaelli, Petr Fojtik, Paolo Gallittu, Mauro Liggi, Arnaldo Amato, Silvia Paggi, Vit Smajstrla, Ondřej Urban, Matteo Erriu, Malcolm Koo, Felix W Leung
Background and study aims Single-center studies, which were retrospective and/or involved unblinded colonoscopists, have suggested that water exchange, but not water immersion, compared with air insufflation significantly increases the adenoma detection rate (ADR), particularly in the proximal and right colon. Head-to-head comparison of the three techniques with ADR as primary outcome and blinded colonoscopists has not been reported to date. In a randomized controlled trial with blinded colonoscopists, we aimed to evaluate the impact of the three insertion techniques on ADR...
March 10, 2017: Endoscopy
https://www.readbyqxmd.com/read/28268235/performance-measures-for-lower-gastrointestinal-endoscopy-a-european-society-of-gastrointestinal-endoscopy-esge-quality-improvement-initiative
#9
Michal F Kaminski, Siwan Thomas-Gibson, Marek Bugajski, Michael Bretthauer, Colin J Rees, Evelien Dekker, Geir Hoff, Rodrigo Jover, Stepan Suchanek, Monika Ferlitsch, John Anderson, Thomas Roesch, Rolf Hultcranz, Istvan Racz, Ernst J Kuipers, Kjetil Garborg, James E East, Maciej Rupinski, Birgitte Seip, Cathy Bennett, Carlo Senore, Silvia Minozzi, Raf Bisschops, Dirk Domagk, Roland Valori, Cristiano Spada, Cesare Hassan, Mario Dinis-Ribeiro, Matthew D Rutter
The European Society of Gastrointestinal Endoscopy and United European Gastroenterology present a short list of key performance measures for lower gastrointestinal endoscopy. We recommend that endoscopy services across Europe adopt the following seven key performance measures for lower gastrointestinal endoscopy for measurement and evaluation in daily practice at a center and endoscopist level: 1 Rate of adequate bowel preparation (minimum standard 90 %); 2 Cecal intubation rate (minimum standard 90 %); 3 Adenoma detection rate (minimum standard 25 %); 4 Appropriate polypectomy technique (minimum standard 80 %); 5 Complication rate (minimum standard not set); 6 Patient experience (minimum standard not set); 7 Appropriate post-polypectomy surveillance recommendations (minimum standard not set)...
March 7, 2017: Endoscopy
https://www.readbyqxmd.com/read/28267007/twenty-years-of-a-veterans-spinal-cord-injury-colorectal-clinic-flexible-sigmoidoscopy-and-multiple-hemorrhoid-ligation
#10
Bard C Cosman, Luis C Cajas-Monson, Sonia L Ramamoorthy
BACKGROUND: Colorectal and anal problems arise in chronic spinal cord injury care. We review 20 years of experience in a colorectal clinic at a veterans medical center treating mostly male veterans who have spinal cord injury. OBJECTIVE: We aim to show the results of colorectal interventions in a population with chronic spinal cord injury. DESIGN: This study is a retrospective records review. SETTINGS: This study was conducted at a Department of Veterans Affairs regional spinal cord injury center...
April 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28266302/should-screening-colonoscopy-be-offered-from-age-50
#11
Hermann Brenner, Nadine Zwink, Leopold Ludwig, Michael Hoffmeister
BACKGROUND: The introduction of colonoscopic screening in 2002 for persons aged 55 and older was followed by a marked decline in the incidence of colon cancer in the corresponding age groups in Germany. The prevalence of colorectal neoplasia among persons aged 50 to 54 has remained unknown until now. Expert committees currently recommend colonoscopic screening for persons aged 50 and older. This option has been offered since 2014 by the AOK Baden-Württemberg and by Bosch BKK in the framework of their specialized medical care program...
February 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28266301/screening-for-bowel-cancer-increasing-participation-via-personal-invitation
#12
Michael Hoffmeister, Bernd Holleczek, Nadine Zwink, Christian Stock, Christa Stegmaier, Hermann Brenner
BACKGROUND: Participation rates in bowel cancer screening programs in Germany continue to be low. In a model project, a logistically simple procedure for inviting patients to participate was tested as a means of increasing participation. METHODS: A randomized trial was performed involving persons residing in the German federal state of Saarland who had either their 50th or their 55th birthday in the year beginning on 1 April 2012 (18 560 and 16 824 persons, respectively)...
February 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28257545/effects-of-starting-a-gastroenterology-fellowship-training-program-on-quality-measures-of-colonoscopy
#13
Sherif Elhanafi, Rahul Chhana, Indika Mallawaarachchi, Wynee Lou, Gabriela Rangel, Hongfei Fang, Rinkal Patel, Alok Kumar Dwivedi, Marc J Zuckerman, Mohamed O Othman
OBJECTIVES: Adenoma detection rate (ADR) is the most established indicator of the quality of screening colonoscopy. The effect of gastroenterology (GI) fellows on the quality of screening colonoscopies has been evaluated previously; however, the effect of starting a new GI fellowship program on the quality of screening colonoscopies has not been studied. The aim of our study was to assess the effects of starting a GI fellowship program and the participation of fellows in screening colonoscopies on ADR and other measures of quality...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28255344/functional-genomic-mrna-profiling-of-colorectal-adenomas-identification-and-in-vivo-validation-of-cd44-and-splice-variant-cd44v6-as-molecular-imaging-targets
#14
Elmire Hartmans, Veronique Orian-Rousseau, Alexandra Matzke-Ogi, Arend Karrenbeld, Derk Jan A de Groot, Steven de Jong, Gooitzen M van Dam, Rudolf S N Fehrmann, Wouter B Nagengast
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. High adenoma miss rates, especially seen in high-risk patients, demand for better endoscopic detection. By fluorescently 'highlighting' specific molecular characteristics, endoscopic molecular imaging has great potential to fulfill this need. To implement this technique effectively, target proteins that distinguish adenomas from normal tissue must be identified. In this study we applied in silico Functional Genomic mRNA (FGmRNA) profiling, which is a recently developed method that results in an enhanced view on the downstream effects of genomic alterations occurring in adenomas on gene expression levels...
2017: Theranostics
https://www.readbyqxmd.com/read/28253712/novel-strategies-for-comprehensive-mutation-screening-of-the-apc-gene
#15
L Wachsmannova, M Mego, V Stevurkova, V Zajac, S Ciernikova
Colorectal cancer is the 4th most common cause of cancer related deaths worldwide and new possibilities in accurate diagnosis and targeted treatment are highly required. Mutations in adenomatous polyposis coli (APC) gene play a pivotal role in adenoma-carcinoma pathway of colorectal tumorigenesis. The quarter century from its´ first cloning, APC became one of the most frequently mutated, known driver genes in colorectal cancer. Intensive routine molecular testing of APC has brought the benefits for patients with family history of polyposis or colorectal cancer...
March 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28251034/polyp-detection-rate-and-pathological-features-in-patients-undergoing-a-comprehensive-colonoscopy-screening
#16
Hamid Asadzadeh Aghdaei, Ehsan Nazemalhosseini Mojarad, Sara Ashtari, Mohmad Amin Pourhoseingholi, Vahid Chaleshi, Fakhrosadat Anaraki, Mehrdad Haghazali, Mohammad Reza Zali
AIM: To identify the prevalence, and clinical and pathologic characteristic of colonic polyps among Iranian patients undergoing a comprehensive colonoscopy, and determine the polyp detection rate (PDR) and adenoma detection rate (ADR). METHODS: In this cross-sectional study, demographics and epidemiologic characteristics of 531 persons who underwent colonoscopies between 2014 and 2015 at Mehrad gastrointestinal clinic were determined. Demographics, indication for colonoscopy, colonoscopy findings, number of polyps, and histopathological characteristics of the polyps were examined for each person...
February 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28251020/regional-clinical-and-biochemical-differences-among-patients-with-primary-hyperparathyroidism
#17
Özer Makay, Beyza Özçınar, Turgay Şimşek, Cumhur Arıcı, Bülent Güngör, Serdar Özbaş, Tamer Akça, Ali Uğur Emre, Güldeniz Karadeniz Çakmak, Müfide Akçay, Bülent Ünal, Mustafa Girgin, Sadullah Girgin, Semih Görgülü, Atakan Sezer, Adem Karataş, İbrahim Ali Özemir, Nihat Aksakal, Serap Erel, M Ümit Uğurlu, Ali İlker Filiz, Can Atalay, Ali Uzunköy, Uğur Deveci, Çetin Kotan, Gökhan İçöz, Yavuz Kurt, Abut Kebudi, N Zafer Cantürk, Yeşim Erbil, Rumen Pandev, Bahadır M Güllüoğlu
BACKGROUND: Environmental habitat may play a role in clinical disparities of primary hyperparathyroidism (pHPT) patients. AIMS: To compare preoperative clinical symptoms and associated conditions and surgical findings in patients with pHPT, living in different geographical regions from the Black Sea, Mediterranean and Anatolia regions. STUDY DESIGN: Retrospective, clinical-based multi-centric study of 694 patients with pHPT. METHODS: Patients from 23 centers and 8 different geographical regions were included...
January 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28246485/coexisting-tubular-adenoma-with-a-neuroendocrine-carcinoma-of-colon-allowing-early-surgical-intervention-and-implicating-a-shared-stem-cell-origin
#18
Mahmoud L Soliman, Ashish Tiwari, Qing Zhao
High-grade colonic neuroendocrine carcinomas (NECs) are uncommon but extremely aggressive. Their co-existence with tubular adenoma (TA) has rarely been reported. We present a 68-year-old man who was found on routine colonoscopy to have multiple colorectal TAs and an ulcerated lesion in the ascending colon. Microscopically, a poorly-differentiated invasive carcinoma juxtaposed with a TA was identified. Differential diagnosis included a poorly-differentiated adenocarcinoma, medullary carcinoma, high-grade NEC and lymphoma...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28243973/presence-of-headache-and-headache-types-in-patients-with-tumors-of-the-sellar-region-can-surgery-solve-the-problem-results-of-a-prospective-single-center-study
#19
Sonja Siegel, Renata Weber Carneiro, Michael Buchfelder, Bernadette Kleist, Agnieszka Grzywotz, Rolf Buslei, Ulrike Bingel, Georg Brabant, Thomas Schenk, Ilonka Kreitschmann-Andermahr
PURPOSE: Headache is a common presenting feature of patients with pituitary adenomas and other tumors of the sellar region. However, at present, it still is unclear whether the headache is actually caused by the tumor. To explore whether there is a relation, we examined in detail the headache types, their relationship to the underlying pathology, and if the headache responded to neurosurgery in a prospective study design. METHODS: One hundred twelve patients with tumors of the sellar region scheduled for neurosurgery in a single center were analyzed for presence and quality of headache before surgery and at least 3 months after surgery...
February 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28224298/the-performance-of-the-msept9-assay-is-influenced-by-algorithm-cancer-stage-and-age-but-not-sex-and-cancer-location
#20
Lele Song, Jia Jia, Haotian Yu, Xiumei Peng, Wenhua Xiao, Yuan Gong, Guangpeng Zhou, Xiaoliang Han, Yuemin Li
PURPOSE: This study aims to examine the influence of algorithm and subject-related factors, including cancer stage, age, sex, and cancer location, on the performance of the SEPT9 gene methylation test, an assay approved by the US FDA for colorectal cancer (CRC) screening. METHODS: A total of 1225 subjects were recruited in this opportunistic screening study, including 388 CRC patients, 139 subjects with adenoma, 108 subjects with hyperplastic polyps, and 590 subjects with no evidence of disease (NED)...
February 21, 2017: Journal of Cancer Research and Clinical Oncology
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