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Adenoma detection rate

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https://www.readbyqxmd.com/read/29682626/adenoma-detection-rate-the-perfect-colonoscopy-quality-measure-or-is-there-more
#1
EDITORIAL
Brian Liem, Neil Gupta
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29680903/the-expression-profile-of-pd-l1-and-cd8-lymphocyte-in-pituitary-adenomas-indicating-for-immunotherapy
#2
Peng-Fei Wang, Ting-Jian Wang, Ya-Kun Yang, Kun Yao, Zhuo Li, Yan Michael Li, Chang-Xiang Yan
BACKGROUND: Pituitary adenomas (PAs) are the second most common brain tumors, and mostly are benign tumors. However, there exists subtypes of PAs refractory to common treatments, and need novel therapy. Programmed death 1 (PD-1) blockade has shown durable objective response in a variety of malignancies, and the key predictive markers for this immunotherapy were PD-L1 and CD8+ tumor-infiltrating lymphocyte (TILs) expression. To evaluate the potential immunotherapy for PAs, we investigated the expression of these two immune markers in PAs...
April 21, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29679692/impact-of-fellowship-training-level-on-colonoscopy-quality-and-efficiency-metrics
#3
Hussein Bitar, Hassaan Zia, Muhammad Bashir, Pratyusha Parava, Muhammad Hanafi, William Tierney, Mohammad Madhoun
BACKGROUND & AIMS: Previous studies have described variable effects of fellow involvement on the adenoma detection rate (ADR), but few have stratified this effect by level of training. We aimed to evaluate the "fellow effect" on multiple procedural metrics including a newly defined adenoma management efficiency index, which may have a role in documenting colonoscopy proficiency for trainees. We also describe the impact of level of training on moderate sedation use. METHODS: We performed a retrospective review of 2024 patients (mean age 60...
April 18, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29664311/feasibility-of-colon-cancer-screening-by-fecal-immunochemical-test-in-iran
#4
Hamideh Salimzadeh, Faraz Bishehsari, Catherine Sauvaget, Mohammad Amani, Gholamreza Hamzehloo, Ali Nikfarjam, Shahin Merat, Alireza Delavari, Reza Malekzadeh
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer in Iran, where there is no mass screening for the disease yet. We aimed to measure the feasibility of a pilot CRC screening program based on fecal immunochemical test (FIT) in Iranian population and the implications for scaling-up at the national level. METHODS: A single quantitative FIT was offered by health navigators to individuals aged between 45 and 75 years in primary health centers in rural and urban areas in Tehran...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29660528/yield-of-colonoscopy-after-a-positive-result-from-a-fecal-immunochemical-test-oc-light
#5
Muhammad Alsayid, Maneesh H Singh, Rachel Issaka, Victoria Laleau, Lukejohn Day, Jeffrey Lee, James Allison, Ma Somsouk
BACKGROUND & AIMS: The fecal immunochemical test (FIT) is widely used in colorectal cancer (CRC) screening. The OC-Light FIT is 1 of 2 FITs recommended for CRC screening by the Preventive Services Task Force guidelines. However, little is known about its ability to detect CRC in large average-risk populations. METHODS: We performed a retrospective cohort study of patients (50-75 years old) in the San Francisco Health Network who were screened for CRC by OC-Light FIT from August 2010 through June 2015...
April 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29616237/the-impact-of-endocuff-assisted-colonoscopy-on-adenoma-detection-in-an-organized-screening-program
#6
Lucas G Cavallaro, Cesare Hassan, Pierenrico Lecis, Ermenegildo Galliani, Elisabetta Dal Pont, Paolo Iuzzolino, Claudia Roldo, Fabio Soppelsa, Bastianello Germanà
Background and study aims:  Colorectal cancer (CRC) screening with biennial fecal occult blood test has been shown to reduce CRC mortality. For the effectiveness of the CRC screening program is crucial that a high-quality colonoscopy with a high adenoma detection rate (ADR) be performed. To improve ADR, various endoscopic devices have been developed. Endocuff, an endoscopic cap with finger-like projections, has been shown to improve ADR. The aim of this study was to compare in an organized CRC screening program ADR, advanced adenoma detection rate (AADR) and mean number of adenomas per patient (MAP) using standard colonoscopy (SC) and Endocuff-assisted colonoscopy (EAC)...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29614263/new-technologies-improve-adenoma-detection-rate-adenoma-miss-rate-and-polyp-detection-rate-a-systematic-review-and-meta-analysis
#7
REVIEW
Daniel Castaneda, Violeta B Popov, Elijah Verheyen, Praneet Wander, Seth A Gross
No abstract text is available yet for this article.
March 31, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29609509/bowel-cancer-screening-for-women-at-midlife
#8
I Olver
In Australia one in 15 women will be diagnosed with colorectal cancer in their lifetime because of the high incidences of lifestyle risk factors. The risk could be reduced by taking aspirin. Evidence-based Clinical Practice Guidelines for the prevention, early detection and management of colorectal cancer produced by Cancer Council Australia and approved by the National Health and Medical Research Council recommended that 'population screening in Australia, directed at those at average risk of colorectal cancer and without relevant symptoms, is immunochemical fecal occult blood testing every 2 years, starting at age 50 years and continuing to age 74 years...
April 3, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29607395/efficacy-of-endocuff-assisted-colonoscopy-in-the-detection-of-colorectal-polyps
#9
Yoshiki Wada, Masayoshi Fukuda, Kazuo Ohtsuka, Mamoru Watanabe, Yumiko Fukuma, Yoko Wada, Masahiro Wada
Background and study aims : Colonoscopy is the gold standard for detecting colorectal adenomas and cancers. Endoscopic surveillance has been shown to be effective for preventing colorectal cancer. Although detection of colorectal polyps at an early stage is important, endoscopic visualization of early neoplasia can be difficult. The Endocuff is a new device that can be attached to the tip of the colonoscope to hold the colonic folds away from the field of view during withdrawal. The aim of this study was to compare the adenoma detection rate (ADR) and the mean number of adenomas detected per patient (MAP) achieved using Endocuff-assisted colonoscopy (EAC) and standard colonoscopy (SC)...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29595045/the-endoscopic-surgical-resection-of-intrasellar-lesions-conserves-the-hormonal-function-a-negative-correlation-to-the-microsurgical-technique
#10
Stefan Linsler, Sebastian Senger, Renate Hero-Gross, Wolf-Ingo Steudel, Joachim Oertel
BACKGROUND: The endonasal endoscopic approach is still currently under investigation for sellar tumour surgery: a higher resection rate is to be expected and complications should be minimized. The authors report their surgical results of endonasal endoscopic neurosurgery with special focus on postoperative hypopituitarism in comparison to microsurgical procedures. METHODS: Sixty patients received endoscopic endonasal transsphenoidal procedures for sellar pathologies...
March 28, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29588842/factors-associated-with-the-efficacy-of-polyp-detection-during-routine-flexible-sigmoidoscopy
#11
Akash J Maliampurakal, Donald C McMillan, John H Anderson, Paul G Horgan, David Mansouri
Objective: Flexible sigmoidoscopy reduces the incidence of colonic cancer through the detection and removal of premalignant adenomas. However, the efficacy of the procedure is variable. The aim of the present study was to examine factors associated with the efficacy of detecting polyps during flexible sigmoidoscopy. Design and patients: Retrospective observational cohort study of all individuals undergoing routine flexible sigmoidoscopy in NHS Greater Glasgow and Clyde from January 2013 to January 2016...
April 2018: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29577224/-relationship-between-the-expression-of-ddx39-protein-and-prognosis-of-colorectal-cancer
#12
Jun Ma, Wenjun Chang, Wei Zhang
OBJECTIVE: To investigate the relationship between the expression of DDX39 protein and prognosis in colorectal cancer. METHODS: Clinical data and paraffin specimens of postoperative tumor tissue from 824 patients with primary colorectal cancer who received first surgical treatment at the Department of Colorectal Surgery of Changhai Hospital of Navy Military Medical University from January 2010 to December 2011 were collected. Paraffin samples of paracancerous tissues of 38 patients were served as controls...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29564038/sessile-serrated-adenoma-detection-rate-is-correlated-with-adenoma-detection-rate
#13
Daisuke Ohki, Yosuke Tsuji, Tomohiro Shinozaki, Yoshiki Sakaguchi, Chihiro Minatsuki, Hiroto Kinoshita, Keiko Niimi, Satoshi Ono, Yoku Hayakawa, Shuntaro Yoshida, Atsuo Yamada, Shinya Kodashima, Nobutake Yamamichi, Yoshihiro Hirata, Tetsuo Ushiku, Mitsuhiro Fujishiro, Masashi Fukayama, Kazuhiko Koike
AIM: To investigated the association between adenoma detection rate (ADR) and sessile serrated ADR (SSADR) and significant predictors for sessile serrated adenomas (SSA) detection. METHODS: This study is a retrospective, single-center analysis. Total colonoscopies performed by the gastroenterologists at the University of Tokyo Hospital between January and December 2014 were retrospectively identified. Polyps were classified as low-grade or high-grade adenoma, cancer, SSA, or SSA with cytological dysplasia, and the prevalence of each type of polyp was investigated...
March 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29562147/helicobacter-pylori-therapy-for-the-prevention-of-metachronous-gastric-cancer
#14
RANDOMIZED CONTROLLED TRIAL
Il Ju Choi, Myeong-Cherl Kook, Young-Il Kim, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Byung-Ho Nam
BACKGROUND: Patients with early gastric cancers that are limited to gastric mucosa or submucosa usually have an advanced loss of mucosal glandular tissue (glandular atrophy) and are at high risk for subsequent (metachronous) development of new gastric cancer. The long-term effects of treatment to eradicate Helicobacter pylori on histologic improvement and the prevention of metachronous gastric cancer remain unclear. METHODS: In this prospective, double-blind, placebo-controlled, randomized trial, we assigned 470 patients who had undergone endoscopic resection of early gastric cancer or high-grade adenoma to receive either H...
March 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29556334/potential-red-flag-identification-of-colorectal-adenomas-with-wide-field-fluorescence-molecular-endoscopy
#15
Elmire Hartmans, Jolien J J Tjalma, Matthijs D Linssen, Pilar Beatriz Garcia Allende, Marjory Koller, Annelies Jorritsma-Smit, Mariana E Silva de Oliveira Nery, Sjoerd G Elias, Arend Karrenbeld, Elisabeth G E de Vries, Jan H Kleibeuker, Gooitzen M van Dam, Dominic J Robinson, Vasilis Ntziachristos, Wouter B Nagengast
Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated adenomas / polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch syndrome. Detection rates may be improved by fluorescence molecular endoscopy (FME), which allows morphological visualization of lesions with high-definition white-light imaging as well as fluorescence-guided identification of lesions with a specific molecular marker. In a clinical proof-of-principal study, we investigated FME for colorectal adenoma detection, using a fluorescently labelled antibody (bevacizumab-800CW) against vascular endothelial growth factor A (VEGFA), which is highly upregulated in colorectal adenomas...
2018: Theranostics
https://www.readbyqxmd.com/read/29541895/differences-with-experienced-nurse-assistance-during-colonoscopy-in-detecting-polyp-and-adenoma-a-randomized-clinical-trial
#16
Weihong Wang, Lu Xu, Zhenfei Bao, Linyin Sun, Chunyan Hu, Feng Zhou, Lei Xu, Dingmei Shi
OBJECTIVES: This study aims to evaluate whether the participation of an experienced endoscopy nurse in colonoscopy increases the polyp detection rate (PDR) and adenoma detection rate (ADR) of experienced colonoscopists. METHODS: This study was a randomized controlled trial. Patients were randomly assigned to the experienced colonoscopist alone (single observer) group, or experienced nurse participation (dual observer) group. The primary outcome was the PDR and ADR...
March 14, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29540604/the-implementation-and-first-round-results-of-a-community-based-colorectal-cancer-screening-program-in-shanghai-china
#17
Yangming Gong, Peng Peng, Pingping Bao, Weijian Zhong, Yan Shi, Kai Gu, Ying Zheng, Chunxiao Wu, Sanjun Cai, Ye Xu, Jun Sheng, Fan Wu
BACKGROUND: The incidence and mortality rate of colorectal cancer (CRC) have increased dramatically over the past 3 decades in China due to changes in lifestyle factors. Early detection and treatment guidelines for asymptomatic cases have shown to improve CRC control in developed countries. In response to these challenges, the Shanghai Municipal Government launched a community-based CRC screening program in 2012. MATERIALS AND METHODS: Free initial screening, inclusive of immunochemical fecal occult blood and risk assessment (questionnaire), was provided by community health centers in Shanghai...
March 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29539651/linked-color-imaging-reduces-the-miss-rate-of-neoplastic-lesions-in-the-right-colon-a-randomized-tandem-colonoscopy-study
#18
Silvia Paggi, Giuseppe Mogavero, Arnaldo Amato, Emanuele Rondonotti, Alida Andrealli, Gianni Imperiali, Nicoletta Lenoci, Giovanna Mandelli, Natalia Terreni, Francesco Simone Conforti, Dario Conte, Giancarlo Spinzi, Franco Radaelli
BACKGROUND:  Linked color imaging (LCI) is a newly developed image-enhancing endoscopy technology that provides bright endoscopic images and increases color contrast. We investigated whether LCI improves the detection of neoplastic lesions in the right colon when compared with high definition white-light imaging (WLI). METHODS:  Consecutive patients undergoing colonoscopy were randomized (1:1) after cecal intubation into right colon inspection at first pass by LCI or by WLI...
March 14, 2018: Endoscopy
https://www.readbyqxmd.com/read/29532430/complete-evaluation-of-pituitary-tumours-in-a-single-tertiary-care-institution
#19
Dimitrios Askitis, Damianos Tsitlakidis, Nicolle Müller, Albrecht Waschke, Gunter Wolf, Ulrich Alfons Müller, Christof Kloos
INTRODUCTION: We retrospectively evaluated all patients with pituitary tumours treated in our department from 1/1/1997 to 01/11/2014. PATIENTS AND METHODS: Two hundred and fifteen patients (124 females, 91 males, mean age 50.9 years) were treated because of pituitary tumours. All patients underwent basal hormonal analysis and when required dynamic testing in order to check for hormonal activity. Pituitary masses were divided into groups concerning their hormonal status and were further classified according to gender, age at diagnosis, tumour size, and the development of postoperative pituitary insufficiency when neurosurgical intervention was conducted...
March 12, 2018: Endocrine
https://www.readbyqxmd.com/read/29527554/linked-color-imaging-enhances-endoscopic-detection-of-sessile-serrated-adenoma-polyps
#20
Daisaku Fujimoto, Naoki Muguruma, Koichi Okamoto, Yasuteru Fujino, Kaizo Kagemoto, Yasuyuki Okada, Yoshifumi Takaoka, Yasuhiro Mitsui, Shinji Kitamura, Tetsuo Kimura, Hiroshi Miyamoto, Yoshimi Bando, Tomoko Sonoda, Tetsuji Takayama
Background and study aims:  Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA/P detection in still image examinations and in a prospective randomized controlled trial (RCT). Patients and methods:  A group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA/P lesions using white light image (WLI), BLI, BLI-bright, and LCI...
March 2018: Endoscopy International Open
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