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Adenoma detection rate

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https://www.readbyqxmd.com/read/29218322/longer-observation-time-increases-adenoma-detection-in-the-proximal-colon-a-prospective-study
#1
Peter Klare, Henrik Phlipsen, Bernhard Haller, Henrik Einwächter, Andreas Weber, Mohamed Abdelhafez, Monther Bajbouj, Hayley Brown, Roland M Schmid, Stefan von Delius
Background and study aims : Longer observation times are associated with increased adenoma detection rates (ADR) in the entire colon. However, adenomas in the proximal colon are at risk of being missed during colonoscopy. The aim of this study was to investigate the impact of observation time on detection of adenomatous polyps in the proximal colon. Patients and methods : This was a prospective study at a university hospital in Germany. Colonoscopies were conducted using magnetic endoscope imaging (MEI) in order to determine the exact position of the scope...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29212310/quality-metrics-of-a-fecal-immunochemical-test-based-colorectal-cancer-screening-program-in-korea
#2
Dae Ho Kim, Jae Myung Cha, Min Seob Kwak, Jin Young Yoon, Young-Hak Cho, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee
Background/Aims: Knowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program. Methods: In our screening program, asymptomatic subjects aged ≥50 years underwent an annual FIT, and subjects with positive FIT results underwent a subsequent colonoscopy. The performance of the FIT and colonoscopy was analyzed in individuals with a positive FIT who completed the program between 2009 and 2015 at a university hospital...
December 8, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29207599/automated-histological-classification-of-whole-slide-images-of-colorectal-biopsy-specimens
#3
Hiroshi Yoshida, Yoshiko Yamashita, Taichi Shimazu, Eric Cosatto, Tomoharu Kiyuna, Hirokazu Taniguchi, Shigeki Sekine, Atsushi Ochiai
Background: An automated image analysis system, e-Pathologist, was developed to improve the quality of colorectal biopsy diagnostics in routine pathology practice. Objective: The aim of the study was to evaluate the classification accuracy of the e-Pathologist image analysis software in the setting of routine pathology practice in two institutions. Materials and methods: In total, 1328 colorectal tissue specimens were consecutively obtained from two hospitals (1077 tissues from Tokyo hospital, and 251 tissues from East hospital) and the stained specimen slides were anonymized and digitized...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205835/colonoscopy-conversion-after-flexible-sigmoidoscopy-screening-results-from-the-uk-bowel-scope-screening-programme
#4
Keith Siau, Andrew Yew, Sauid Ishaq, Sarah Jewes, Sharan Shetty S, Matthew Brookes, Andrew Veitch, Brian McKaig, Aravinth Murugananthan
INTRODUCTION: In the UK Bowel Scope screening programme (BSSP), patients progress to colonoscopy based on high-risk features on flexible sigmoidoscopy (FS). OBJECTIVE: To assess practice of colonoscopy conversion and predictors of additional adenoma detection on colonoscopy. DESIGN: The Bowel Cancer Screening database was interrogated and collated with endoscopic and histological findings from patients undergoing colonoscopy following FS between August 2013 and August 2016...
December 5, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29202001/validating-bowel-preparation-scales
#5
Valérie Heron, Robin Parmar, Charles Ménard, Myriam Martel, Alan N Barkun
Background and study aim:  Few scales assessing bowel preparation quality have been validated, and direct between-scale comparisons remain scarce. The aim of the study was to compare inter- and intra-rater reliability, predictive abilities for clinical outcomes, and ease of use for each scale. Methods:  Colonoscopy video recordings highlighting five colonic segments after washing were viewed independently by three physicians, and cleanliness was evaluated using the Boston Bowel Preparation Scale (BBPS), the Chicago Bowel Preparation Scale (CBPS), and the Harefield Cleansing Scale (HCS) in randomized order...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29184610/colonoscopy-procedural-volume-increases-adenoma-and-polyp-detection-rates-in-gastroenterologytrainees
#6
Emad Qayed, Ravi Vora, Sara Levy, Roberd M Bostick
AIM: To investigate changes in polyp detection throughout fellowship training, and estimate colonoscopy volume required to achieve the adenoma detection rate (ADRs) and polyp detection rate (PDRs) of attending gastroenterologists. METHODS: We reviewed colonoscopies from July 1, 2009 to June 30, 2014. Fellows' procedural logs were used to retrieve colonoscopy procedural volumes, and these were treated as the time variable. Findings from screening colonoscopies were used to calculate colonoscopy outcomes for each fellow for the prior 50 colonoscopies at each time point...
November 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29184444/development-and-validation-of-a-panel-of-five-proteins-as-blood-biomarkers-for-early-detection-of-colorectal-cancer
#7
Hongda Chen, Jing Qian, Simone Werner, Katarina Cuk, Phillip Knebel, Hermann Brenner
Objective: Reliable noninvasive biomarkers for early detection of colorectal cancer (CRC) are highly desirable for efficient population-based screening with high adherence rates. We aimed to discover and validate blood-based protein markers for the early detection of CRC. Patients and methods: A two-stage design with a discovery and a validation set was used. In the discovery phase, plasma levels of 92 protein markers and serum levels of TP53 autoantibody were measured in 226 clinically recruited CRC patients and 118 controls who were free of colorectal neoplasms at screening colonoscopy...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29184430/evaluation-of-a-fecal-immunochemistry-test-prior-to-colonoscopy-for-outpatients-with-various-indications
#8
Andrew Szilagyi, Xiaoqing Xue
Background: Stool tests can predict advanced neoplasms prior to colonoscopy. Results of immunochemical stool tests to predict findings at colonoscopy for various indications are less often reported. We compared pre-colonoscopy stool tests with findings in patients undergoing colonoscopy for different indications. Patients and methods: Charts of patients undergoing elective or semi-urgent colonoscopy were reviewed. Comparison of adenoma detection rates and pathological findings was made between prescreened and non-prescreened, and between stool-positive and stool-negative cases...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29178094/-status-quo-of-colorectal-cancer-screening-in-guangzhou-community
#9
Yujie Zhao, Zhizhong Pan
The incidence of colorectal cancer (CRC) in China is gradually increasing as a result of the economic development and dietary change. Since it usually takes a long time for precancerous lesions (e.g. adenoma) to develop into cancer, proper cancer screening is useful to discover and to remove these early lesions, while the patients can achieve long-term survival. Hence, developing a well-organized cancer screening system is necessary for the early detection and intervention of potential CRC. Sun Yat-sen University Cancer Center (SYSUCC) has been developing a community-based cancer screening program, using questionnaires and fecal occult blood test to identify the residents with high risks of CRC...
November 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29174953/signature-celebration-of-gastroenterology-colorectal-cancer
#10
Andrew T Chan, Paul Moayyedi
Gastroenterology has published many seminal articles that have transformed our understanding of colorectal cancer (CRC) as well as being influential in promoting colorectal cancer screening which has saved many people from developing the disease. CRC has a hereditary component most notably highlighted in Lynch syndrome. A key paper reported that the majority of mutations in patients with hereditary nonpolyposis colorectal cancer harbored mutations in the MLH1 or MSH2 mismatch repair proteins. Continuing on the gene mutation theme, another paper...
November 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29170448/colorectal-cancer-screening-in-patients-with-spinal-cord-injury-yields-similar-results-to-the-general-population-with-an-effective-bowel-preparation-a-retrospective-chart-audit
#11
Brandon J Teng, Shawn H Song, Jelena N Svircev, Jason A Dominitz, Stephen P Burns
STUDY DESIGN: Retrospective chart audit. OBJECTIVES: To compare adequacy of colonoscopy bowel preparation and diagnostic findings between persons with SCI receiving an extended inpatient bowel preparation and the general population. SETTING: Veterans Affairs Puget Sound Healthcare System, Seattle, WA, USA. METHODS: We reviewed an electronic database of all colonoscopies performed at a tertiary Veterans Affairs medical center between 7/12/13 and 15/10/15...
November 24, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29162970/fice-in-predicting-colorectal-flat-lesion-histology
#12
Cevher Akarsu, Nuri A Sahbaz, Ahmet C Dural, Osman Kones, Sinan Binboga, Hamit A Kabuli, Alpen Y Gumusoglu, Halil Alis
Background and Objectives: Colonoscopy is the gold standard for detection of polyps and is preventive against colorectal cancers. Flat adenomas are small, superficial lesions and have a high rate of going undetected during conventional white-light endoscopy. This article adds to the scant body of literature in English regarding in vivo detection and diagnosis of flat adenomas using Fujinon intelligent color enhancement (FICE) system. In this study, we investigated the diagnosis of flat lesions via the FICE endoscopy system and in vivo histologic diagnostic estimations of flat lesions...
October 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#13
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29142517/is-methylation-analysis-of-sfrp2-tfpi2-ndrg4-and-bmp3-promoters-suitable-for-colorectal-cancer-screening-in-the-korean-population
#14
Soo-Kyung Park, Hae Lim Baek, Junghee Yu, Ji Yeon Kim, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jeong, Ho-Kyung Chun, Kyungeun Kim, Dong Il Park
Background/Aims: Colorectal cancer (CRC) screening using stool DNA was recently found to yield good detection rates. A multi-target stool DNA test (Cologuard®, Exact Sciences), including methylated genes has been recently approved by the U.S. Food and Drug Administration. The aim of this study was to validate these aberrantly methylated genes as stool-based DNA markers for detecting CRC and colorectal advanced adenoma (AA) in the Korean population. Methods: A single-center study was conducted in 36 patients with AA; 35 patients with CRC; and 40 endoscopically diagnosed healthy controls using CRC screening colonoscopy...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29133257/comparative-efficacy-of-colonoscope-distal-attachment-devices-in-increasing-rates-of-adenoma-detection-a-network-meta-analysis
#15
REVIEW
Antonio Facciorusso, Valentina Del Prete, Rosario Vincenzo Buccino, Nicola Della Valle, Maurizio Cosimo Nacchiero, Fabio Monica, Renato Cannizzaro, Nicola Muscatiello
BACKGROUND & AIMS: Several add-on devices have been developed to increase rates of colon adenoma detection (ADR). We assessed their overall and comparative efficacy, and estimated absolute magnitude of benefit through a network meta-analysis. METHODS: We searched the PubMed/Medline and Embase database through March 2017 and identified 25 randomized controlled trials (comprising 16,103 patients) that compared the efficacy of add-on devices (cap, Endocuff, and Endorings) with each other or with standard colonoscopy...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29132175/simethicone-improves-bowel-cleansing-with-low-volume-polyethylene-glycol-a-multicenter-randomized-trial
#16
Shenghong Zhang, Danping Zheng, Jinping Wang, Jianwei Wu, Pingguang Lei, Qi Luo, Liping Wang, Beiping Zhang, Hong Wang, Yi Cui, Minhu Chen
Background and study aims For bowel preparation, using a reduced volume of polyethylene glycol (PEG) solution without influencing its effectiveness would be preferable. While simethicone shows great potential as an adjunctive agent, data on its use are limited. We aimed to clarify whether simethicone added to low-volume PEG solution improved bowel cleansing. Patients and methods Consecutive adult patients registered for colonoscopy were recruited from seven medical centers in South China between 15 April and 15 July 2015 and prospectively randomized into two groups: 2 L PEG (conventional group) and 2 L PEG plus simethicone (simethicone group)...
November 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29132174/feasibility-safety-and-diagnostic-yield-of-the-extra-wide-angle-view-ewave-colonoscope-for-the-detection-of-colorectal-lesions
#17
Maxime E S Bronzwaer, Evelien Dekker, Vincens Weingart, Stefan Groth, Mathieu Pioche, Jérôme Rivory, Torsten Beyna, Horst Neuhaus, Thierry Ponchon, Hans Allescher, Paul Fockens, Thomas Rösch
Background and study aims The adenoma detection rate (ADR) of conventional colonoscopy can still be improved. We conducted a prospective multicenter cohort study to assess the feasibility, safety, and diagnostic yield of the Extra Wide Angle View (EWAVE) colonoscope, which offers a 235° view obtained from a forward-viewing and two lateral backward-viewing lenses incorporated into one image. Patients and methods The study was performed between November 2015 and June 2016. EWAVE colonoscopy was performed in patients with an increased risk of colorectal cancer by experienced and EWAVE-trained endoscopists (≥ 500 colonoscopies, ≥ 10 with the EWAVE system)...
November 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29122597/upper-gi-involvement-in-children-with-familial-adenomatous-polyposis-syndrome-single-center-experience-and-meta-analysis-of-the-literature
#18
Luz H Gutierrez Sanchez, Mouaz Alsawas, Michael Stephens, Mohammad Hassan Murad, Imad Absah
BACKGROUND AND AIMS: Familial adenomatous polyposis (FAP) is a hereditary syndrome that can affect the entire GI tract. Current screening recommendations include esophagogastroduodenoscopy (EGD) starting at age 25 to 30 years or earlier in symptomatic patients. However, there are few reports describing upper GI tract involvement in children with FAP which support the notion of early screening. The aim of our study is to understand the prevalence and severity of upper GI involvement in children with FAP...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29118558/cap-assisted-colonoscopy-versus-standard-colonoscopy-is-the-cap-beneficial-a-meta-analysis-of-randomized-controlled-trials
#19
Fazia A Mir, Christine Boumitri, Imran Ashraf, Michelle L Matteson-Kome, Douglas L Nguyen, Srinivas R Puli, Matthew L Bechtold
Background: In an effort to improve visualization during colonoscopy, a transparent plastic cap or hood may be placed on the end of the colonoscope. Cap-assisted colonoscopy (CAC) has been studied and is thought to improve polyp detection. Numerous studies have been conducted comparing pertinent clinical outcomes between CAC and standard colonoscopy (SC) with inconsistent results. Methods: Numerous databases were searched in November 2016. Only randomized controlled trials (RCTs) involving adult subjects that compared CAC to SC were included...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29103185/trends-in-surgery-hospital-admissions-and-imaging-for-pituitary-adenomas-in-australia
#20
Sjorjina Crowther, R Louise Rushworth, Wayne Rankin, Henrik Falhammar, Liza K Phillips, David J Torpy
PURPOSE: There is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia. METHODS: Australian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed. RESULTS: In 2014/15 there were 37.7 pituitary procedures/million population, corresponding to a 35...
November 4, 2017: Endocrine
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