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Adenoma detection rate

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https://www.readbyqxmd.com/read/28713060/a-standardized-imaging-protocol-for-the-endoscopic-prediction-of-dysplasia-within-sessile-serrated-polyps-with-video
#1
David J Tate, Mahesh Jayanna, Halim Awadie, Lobke Desomer, Ralph Lee, Stephen J Heitman, Mayenaaz Sidhu, Kathleen Goodrick, Nicholas G Burgess, Hema Mehajan, Duncan McLeod, Michael J Bourke
BACKGROUND AND AIMS: Dysplasia within sessile serrated polyps (SSPs) is difficult to detect, may be mistaken for an adenoma risking incomplete resection of the background serrated tissue, and is strongly implicated in interval cancer after colonoscopy. The use of endoscopic imaging to detect dysplasia within SSP has not been systematically studied. METHODS: Consecutively detected SSP ≥8 mm in size were evaluated using a standardized imaging protocol at a tertiary endoscopy center over 3 years...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28706415/role-of-new-endoscopic-techniques-in-inflammatory-bowel-disease-management-has-the-change-come
#2
EDITORIAL
Loredana Goran, Lucian Negreanu, Ana Maria Negreanu
Despite significant therapeutic progress in recent years, inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, remains a challenge regarding its pathogenesis and long-term complications. New concepts have emerged in the management of this disease, such as the "treat-to-target" concept, in which mucosal healing plays a key role in the evolution of IBD, the risk of recurrence and the need for surgery. Endoscopy is essential for the assessment of mucosal inflammation and plays a pivotal role in the analysis of mucosal healing in patients with IBD...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28702134/evaluating-the-frequency-of-mlh-1-loss-in-serrated-polyps-of-colon-a-single-center-study-from-southern-iran
#3
Bita Geramizadeh, Nooshin Dindar, Samirasadat Hasheminasab, Tahere Haeidari
AIM: Evaluation of the role of MLH-1 loss in serrated polyps of colon in a population of South of Iran. BACKGROUND: There has been extensive change in classification and pathogenesis of serrated polyps of the colon during the last 10 years. The new classification is mostly based on the knowledge of the molecular pathogenesis and the rate of progression to colorectal cancer in these types of polyps. One of the most common and early lesions in molecular pathogenesis of serrated colorectal cancer is loss of MLH-1...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28691054/use-of-warm-carbon-dioxide-insufflators-does-not-affect-intra-colonic-gas-temperature-and-has-no-effect-on-polyp-detection-rate-during-colonoscopy-a-randomized-controlled-trial
#4
Akash M Patel, Jordan Green, Fahd Jowhari, Lawrence Hookey
BACKGROUND AND STUDY AIMS : Methods to improve polyp detection during colonoscopy have been investigated, with conflicting results for warm water irrigation. Carbon Dioxide (CO 2) warmed to 37 °C may have similar or more pronounced effects on bowel motility. This study aimed to assess whether warmed CO 2 would improve polyp detection compared to room temperature air insufflation. PATIENTS AND METHODS:  This was a double-blind, randomized controlled trial that enrolled 204 patients undergoing screening or surveillance outpatient colonoscopy...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28691053/performance-report-cards-increase-adenoma-detection-rate
#5
Michael Sai Lai Sey, Andy Liu, Samuel Asfaha, Victoria Siebring, Vipul Jairath, Brian Yan
BACKGROUND AND STUDY AIMS : Adenoma detection rate (ADR) is an important measure of colonoscopy quality, as are polyp, advanced ADR, and adenocarcinoma detection rates. We investigated whether performance report cards improved these outcome measures. PATIENTS AND METHODS : Endoscopists were given report cards comparing their detection rates to the institutional mean on an annual basis. Detection rates were evaluated at baseline, 1 year after report cards (Year 1), and 2 years after report cards (Year 2)...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28690771/multicenter-randomised-controlled-trial-comparing-the-high-definition-white-light-endoscopy-and-the-bright-narrow-band-imaging-for-colon-polyps
#6
Rajvinder Singh, Kuan Loong Cheong, Leonardo Zorron Cheng Tao Pu, Dileep Mangira, Doreen Siew Ching Koay, Carmen Kee, Siew Chien Ng, Rungsun Rerknimitr, Satimai Aniwan, Tiing-Leong Ang, Khean-Lee Goh, Shiaw Hooi Ho, James Yun-Wong Lau
AIM: To compare high definition white light endoscopy and bright narrow band imaging for colon polyps' detection rates. METHODS: Patients were randomised to high definition white light endoscopy (HD-WLE) or the bright narrow band imaging (bNBI) during withdrawal of the colonoscope. Polyps identified in either mode were characterised using bNBI with dual focus (bNBI-DF) according to the Sano's classification. The primary outcome was to compare adenoma detection rates (ADRs) between the two arms...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28678324/screening-and-identification-of-a-tumor-specific-methylation-phenotype-in-the-colorectal-laterally-spreading-tumor
#7
H-B Ni, F-Y Wang, J Xu, X-J He, J Chen, Q Wu, J-F Wu, Y-S Sun
OBJECTIVE: We screened and identified the differential expression of the methylation phenotype in the whole genome of colorectal laterally spreading tumor (LSTs). MATERIALS AND METHODS: 3 tissue samples of colorectal polypoid adenomas (PAs), 3 tissue samples of LSTs and 3 tissue samples of colon cancer were analyzed with a high-density gene chip, and about 450,000 methylation sites were detected covering approximately 95% of the CpG islands. The Delta Data screening was taken through a cluster analysis of methylation phenotype differential expression...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28675478/full-spectrum-versus-standard-colonoscopy-for-improving-polyp-detection-rate-a-systematic-review-and-meta-analysis
#8
Antonio Facciorusso, Valentina Del Prete, Vincenzo Buccino, Nicola Della Valle, Maurizio Cosimo Nacchiero, Nicola Muscatiello
BACKGROUND AND AIM: Full-spectrum endoscopy represents a new endoscopic platform allowing a panoramic 330 degree view of the colon but evidence of its superiority over standard colonoscopy is still lacking. Our study is the first meta-analysis comparing the efficacy of Full-spectrum endoscopy versus standard colonoscopy. METHODS: Through a systematic literature review until May 2017, we identified 8 randomized-controlled trials. Primary outcomes were polyp detection rate and adenoma detection rate, while cecal intubation time and total colonoscopy time were secondary outcomes...
July 4, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28670239/miss-rate-of-colorectal-neoplastic-polyps-and-risk-factors-for-missed-polyps-in-consecutive-colonoscopies
#9
Nam Hee Kim, Yoon Suk Jung, Woo Shin Jeong, Hyo-Joon Yang, Soo-Kyung Park, Kyuyong Choi, Dong Il Park
BACKGROUND/AIMS: Colonoscopic polypectomy is the best diagnostic and therapeutic tool to detect and prevent colorectal neoplasms. However, previous studies have reported that 17% to 28% of colorectal polyps are missed during colonoscopy. We investigated the miss rate of neoplastic polyps and the factors associated with missed polyps from quality-adjusted consecutive colonoscopies. METHODS: We reviewed the medical records of patients who were found to have colorectal polyps at a medical examination center of the Kangbuk Samsung Hospital between March 2012 and February 2013...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28655982/clinical-impact-of-the-immunochemical-fecal-occult-blood-test-for-colorectal-cancer-screening-in-brazil
#10
Cláudio R Teixeira, Michele L Bonotto, Júlio P Lima, Luciana F Figueiredo, Leonardo Conrado, Carlos Frasca
BACKGROUND: Colorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease. METHODS: This population-based study was performed between April 2015 and January 2016 in two gastroenterology referral centers in Southern Brazil. It included 1039 average-risk volunteers aged 50-75 years who were symptom-free for colonic disease...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28649124/a-modified-bowel-preparation-regimen-for-colonoscopy-providing-the-patients-satisfaction-and-convenience
#11
Chia-Cheng Wen, Shu-Wen Jao, Cheng-Wen Hsiao
BACKGROUND A complete cleansing of the bowel is a critical factor that impacts the diagnostic accuracy of colonoscopies. However, the common bowel preparation regimen of two 45 mL doses of sodium phosphate (2×NaP) often leads to uncomfortable symptoms and subsequently lower patient adherence. To improve patient adherence and satisfaction, we proposed a modified regimen composed of two sennoside tablets and one bottle of NaP (S+NaP) and we then evaluated bowel preparation quality and patient satisfaction. MATERIAL AND METHODS A total of 531 patients who underwent colonoscopies at the outpatient coloproctology clinic from January 2016 to December 2016 were retrospectively reviewed...
June 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28648577/impact-of-cap-assisted-colonoscopy-on-learning-curve-and-quality-in-colonoscopy-a-randomized-controlled-trial
#12
Zhouwen Tang, Daniel S Zhang, Aaron P Thrift, Kalpesh K Patel
BACKGROUND AND AIMS: Colonoscopy competency assessment in trainees have traditionally been informal. Comprehensive metrics such as the Assessment of Competency in Endoscopy (ACE) tool suggest competency thresholds are higher than assumed. cap-assisted colonoscopy (CAC) may improve competency but data in novice trainees are lacking. We compare CAC versus standard colonoscopy (SC) among novice trainees in a randomized controlled trial. METHODS: All colonoscopies performed by 3 gastroenterology fellows without prior experience were eligible for enrollment...
June 22, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28643529/correlation-between-adenoma-detection-rate-and-novel-quality-indicators-for-screening-colonoscopy-a-proposal-for-quality-measures-tool-kit
#13
Mohamed M Abdelfatah, Sherif Elhanafi, Marc J Zuckerman, Mohamed O Othman
BACKGROUND AND AIMS: Adenoma detection rate (ADR) is the most validated quality indicator for colonoscopy. Calculating ADR may not yield information in regards to advanced adenoma detection rate (advanced ADR). In addition, calculating ADR for individual endoscopists cannot distinguish between those who find only one versus more than one adenoma per colonoscopy. Several novel quality indictors were recently proposed to ensure adequate assessment of quality during colonoscopy. Our study aims to determine the correlation between ADR and novel quality indicators...
June 23, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28638218/new-endoscopes-and-add-on-devices-to-improve-colonoscopy-performance
#14
REVIEW
Paraskevas Gkolfakis, Georgios Tziatzios, George D Dimitriadis, Konstantinos Triantafyllou
Colonoscopy is the gold standard for colorectal cancer prevention; however, it is still an imperfect modality. Precancerous lesions can be lost during screening examinations, thus increasing the risk of interval cancer. A variety of factors either patient-, or endoscopist dependent or even the procedure itself may contribute to loss of lesions. Sophisticated modalities including advanced technology endoscopes and add-on devices have been developed in an effort to eliminate colonoscopy's drawbacks and maximize its ability to detect potentially culprit polyps...
June 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28626987/prolactinomas-diagnosed-in-the-postmenopausal-period-clinical-phenotype-and-outcomes
#15
Sandhya Santharam, Metaxia Tampourlou, Wiebke Arlt, John Ayuk, Neil Gittoes, Andrew Toogood, Rachel Webster, Niki Karavitaki
OBJECTIVE: Most prolactinomas in females are diagnosed during the reproductive age and the majority are microadenomas. Prolactinomas detected in the postmenopausal period are less common with limited published data on their presentation and prognosis. Our objective was to assess the presenting clinical, biochemical and imaging findings, as well as the outcomes of women diagnosed with a prolactinoma in the postmenopausal period. DESIGN AND METHODS: We undertook a retrospective cohort study of women diagnosed with prolactinoma after menopause and followed-up in a large UK pituitary center...
June 19, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28621643/the-clinical-effectiveness-of-different-surveillance-strategies-to-prevent-colorectal-cancer-in-people-with-intermediate-grade-colorectal-adenomas-a-retrospective-cohort-analysis-and-psychological-and-economic-evaluations
#16
Wendy Atkin, Amy Brenner, Jessica Martin, Katherine Wooldrage, Urvi Shah, Fiona Lucas, Paul Greliak, Kevin Pack, Ines Kralj-Hans, Ann Thomson, Sajith Perera, Jill Wood, Anne Miles, Jane Wardle, Benjamin Kearns, Paul Tappenden, Jonathan Myles, Andrew Veitch, Stephen W Duffy
BACKGROUND: The UK guideline recommends 3-yearly surveillance for patients with intermediate-risk (IR) adenomas. No study has examined whether or not this group has heterogeneity in surveillance needs. OBJECTIVES: To examine the effect of surveillance on colorectal cancer (CRC) incidence; assess heterogeneity in risk; and identify the optimum frequency of surveillance, the psychological impact of surveillance, and the cost-effectiveness of alternative follow-up strategies...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28614895/endocuff-assisted-vs-standard-colonoscopy-in-the-fecal-occult-blood-test-based-uk-bowel-cancer-screening-programme-e-cap-study-a-randomized-trial
#17
Rupam Bhattacharyya, Fergus Chedgy, Kesavan Kandiah, Carole Fogg, Bernard Higgins, Ben Haysom-Newport, Lisa Gadeke, Fergus Thursby-Pelham, Richard Ellis, Patrick Goggin, Gaius Longcroft-Wheaton, Pradeep Bhandari
Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This parallel group, single-blinded, randomized controlled trial included patients with positive fecal occult blood test (FOBT) who were attending for BCSP colonoscopy. The primary outcome was the number of polyps per patient. Secondary outcomes included the number of adenomas per patient, adenoma and polyp detection rates, and withdrawal times...
June 14, 2017: Endoscopy
https://www.readbyqxmd.com/read/28599473/colorectal-cancer-in-cases-of-multiple-primary-cancers-clinical-features-of-59-cases-and-point-mutation-analyses
#18
Anshan Wu, Siqi He, Jingjing Li, Ling Liu, Chunlan Liu, Qi Wang, Xiaowei Peng, Jianda Zhou, Pei-Guo Cao, Ke Cao
The present study aimed to investigate the occurrence and clinical features of cases of multiple primary cancers including colorectal cancer (MPCC). The medical records of patients with colorectal cancer (CRC) who underwent surgery at the Third Xiangya Hospital of Central South University (Changsha, China) between August 2007 and August 2014 were retrospectively analyzed. Patients with MPCCs were identified and mutation analyses were performed on colon specimens. The results revealed that among 1,311 patients with CRC, 59 had MPCC (including 35 cases of ≥1 CRC with ≥1 other cancer type, and 24 cases with multiple CRCs and no other primary cancers)...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28594696/quality-measures-in-gastrointestinal-endoscopy-the-current-state
#19
Megan A Adams, Sameer D Saini, John I Allen
PURPOSE OF REVIEW: The purpose of this review is to summarize the current state of endoscopic quality measurement and use of measures in enhancing the value of endoscopic services. RECENT FINDINGS: Initially, quality measurement of endoscopic procedures was claims based or included small unit or practice-specific efforts. Now we have a mature national registry and large electronic medical or procedural records that are designed to yield valuable data relevant to quality measurement...
June 7, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28592038/-the-application-of-captopril-challenge-test-in-the-diagnosis-of-primary-aldosteronism
#20
S Chen, Z P Zeng, A L Song, L Zhu, L Lu, A L Tong, C Shi, H Z Li
Objective: To evaluate the value of captopril challenge test (CCT) in the diagnosis of primary aldosteronism (PA). Methods: A total of 674 patients [(45.0±13.7) years, men 341, women 333] admitted to Peking Union Medical College Hospital from 2000 to 2015 were analyzed. Among them, 222 subjects were with essential hypertension (EH), 28 were with pheochromocytoma (PHEO), 246 were with idiopathic hyperaldosteronism (IHA) and 178 were with aldosterone producing adenoma (APA). All patients received CCT. 24 h urine sodium was measured in partial patients...
June 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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