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https://www.readbyqxmd.com/read/29777108/factor-xiiia-expressing-inflammatory-monocytes-promote-lung-squamous-cancer-through-fibrin-cross-linking
#1
Alessandro Porrello, Patrick L Leslie, Emily B Harrison, Balachandra K Gorentla, Sravya Kattula, Subrata K Ghosh, Salma H Azam, Alisha Holtzhausen, Yvonne L Chao, Michele C Hayward, Trent A Waugh, Sanggyu Bae, Virginia Godfrey, Scott H Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D Wilkerson, D Neil Hayes, H Shelton Earp, Albert S Baldwin, Alisa S Wolberg, Chad V Pecot
Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival...
May 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29775605/outcomes-of-planned-2-stage-hybrid-aortic-repair-with-dacron-replaced-proximal-landing-zone
#2
David N Ranney, Babatunde A Yerokun, Ehsan Benrashid, Muath Bishawi, Adam Williams, Richard L McCann, G Chad Hughes
BACKGROUND: Results of hybrid arch repair (HAR) utilizing native zone 0 proximal landing zone (PLZ) have been unsatisfactory in many series, especially in the setting of ascending aortic dilation (>4.0 cm). This study reports early and late outcomes of planned 2-stage HAR with open 1st stage proximal aortic replacement (PAR) followed by 2nd stage thoracic endovascular aortic repair (TEVAR) with PLZ within the Dacron replaced zone 0. METHODS: N=34 patients underwent planned 2-stage HAR between 1/2006-8/2017...
May 15, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29771685/enterotoxigenic-escherichia-coli-blood-group-a-interactions-intensify-diarrheal-severity
#3
Pardeep Kumar, F Matthew Kuhlmann, Subhra Chakroborty, A Louis Bourgeois, Jennifer Foulke-Abel, Brunda Tumala, Tim J Vickers, David A Sack, Barbara DeNearing, Clayton D Harro, W Shea Wright, Jeffrey C Gildersleeve, Matthew A Ciorba, Srikanth Santhanam, Chad K Porter, Ramiro L Gutierrez, Michael G Prouty, Mark S Riddle, Alexander Polino, Alaullah Sheikh, Mark Donowitz, James M Fleckenstein
Enterotoxigenic Escherichia coli (ETEC) infections are highly prevalent in developing countries where clinical presentations range from asymptomatic colonization to severe cholera-like illness. The molecular basis for these varied presentations, that may involve strain-specific virulence features as well as host factors, have not been elucidated. We demonstrate that when challenged with ETEC strain H10407, originally isolated from a case of cholera-like illness, blood group A human volunteers developed severe diarrhea more frequently than individuals from other blood groups...
May 17, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29771394/the-effect-of-intraoperative-hypothermia-on-shoulder-arthroplasty
#4
Toufic R Jildeh, Kelechi R Okoroha, Nathan E Marshall, Chad Amato, Hunter Trafton, Stephanie J Muh, Patricia Kolowich
Limited evidence is available regarding the correlation between intraoperative hypothermia and perioperative complications in shoulder arthroplasty. The purpose of this study was to determine the incidence of intraoperative hypothermia in patients treated with shoulder arthroplasty and its effect on perioperative complications. A retrospective chart review was performed on 657 consecutive patients who underwent shoulder arthroplasty at a single institution between August 2013 and June 2016. Demographic data, surgery-specific data, postoperative complications, length of stay, and 30-day read-mission were recorded...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29770515/structural-variation-and-rates-of-genome-evolution-in-the-grass-family-seen-through-comparison-of-sequences-of-genomes-greatly-differing-in-size
#5
Jan Dvorak, Le Wang, Tingting Zhu, Chad M Jorgensen, Karin R Deal, Xiongtao Dai, Matthew W Dawson, Hans-Georg Müller, Ming-Cheng Luo, Ramesh K Ramasamy, Hamid Dehghani, Yong Q Gu, Bikram S Gill, Assaf Distelfeld, Katrien M Devos, Peng Qi, Frank M You, Patrick J Gulick, Patrick E McGuire
Homology was searched with genes annotated in the Aegilops tauschii pseudomolecules against genes annotated in the pseudomolecules of tetraploid wild emmer wheat, Brachypodium distachyon, sorghum, and rice. Similar searches were initiated with genes annotated in the rice pseudomolecules. Matrices of colinear genes and rearrangements in their order were constructed. Optical Bionano genome maps were constructed and used to validate rearrangements unique to the wild emmer and Ae. tauschii genomes. Most common rearrangements were short paracentric inversions and short intrachromosomal translocations...
May 16, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29766018/usefulness-of-simultaneous-screening-for-hiv-and-hepatitis-c-specific-antibodies-and-hepatitis-b-surface-antigen-by-capillary-based-multiplex-immunochromatographic-rapid-test-to-strengthen-prevention-strategies-and-linkage-to-care-in-childbearing-aged-women
#6
Ralph-Sydney Mboumba Bouassa, Zita Aleyo Nodjikouambaye, Damtheou Sadjoli, Ali Mahamat Moussa, Chatte Adawaye, Donato Koyalta, Laurent Bélec
Childbearing-aged women (n = 266) attending a gynecological clinic in Chad were subjected to multiplex immunochromatographic rapid test for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). Ten (3.7%) and 8 (3.0%) were seropositive for HIV and HCV, respectively, and 20 (7.5%) for HBV surface antigen, allowing diagnosis of chronic viral infections in 1 of 7 (14.3%) women.
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29762189/orthopaedic-resident-surgical-case-log-disparities-observed-in-the-next-accreditation-system
#7
Jonathan H Payne, Chad A Krueger, Jessica C Rivera, Patrick M Osborn
INTRODUCTION: With the institution of the Next Accreditation System (NAS), case log procedures fundamentally changed. Unless multiple entries are made, only one procedure per case is credited for procedure counts. We hypothesized that the NAS caused notable changes in national procedure data. METHODS: Accreditation Council for Graduate Medical Education Orthopaedic Surgery Case Logs National Data Reports from 2008 to 2016 were analyzed to calculate differences in case log data before and after NAS implementation...
May 14, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29762017/the-role-of-structural-enthalpy-in-spherical-nucleic-acid-hybridization
#8
Lam-Kiu Fong, Ziwei Wang, George C Schatz, Erik Luijten, Chad A Mirkin
DNA hybridization onto DNA-functionalized nanoparticle surfaces (e.g., in the form of a spherical nucleic acid (SNA)) is known to be enhanced relative to hybridization free in solution. Surprisingly, via isothermal titration calorimetry, we reveal that this enhancement is enthalpically, as opposed to entropically, dominated by ∼20 kcal/mol. Coarse-grained molecular dynamics simulations suggest that the observed enthalpic enhancement results from structurally confining the DNA on the nanoparticle surface and preventing it from adopting enthalpically unfavorable conformations like those observed in the solution case...
May 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29761286/a-qualitative-analysis-of-stress-and-relaxation-themes-contributing-to-burnout-in-first-year-psychiatry-and-medicine-residents
#9
Nicole M Benson, Deanna Chaukos, Heather Vestal, Emma F Chad-Friedman, John W Denninger, Christina P C Borba
OBJECTIVE: Qualitative research on trainee well-being can add nuance to the understanding of propagators of burnout, and the role for interventions aimed at supporting well-being. This qualitative study was conducted to identify (i) situations and environments that cause stress for trainees, (ii) stress-reducing activities that trainees utilize, and (iii) whether trainees who report distress (high burnout and depression scores) describe different stressors and relaxation factors than those who do not...
May 14, 2018: Academic Psychiatry
https://www.readbyqxmd.com/read/29760854/peritoneal-dialysis-in-austere-environments-an-emergent-approach-to-renal-failure-management
#10
REVIEW
Chad Gorbatkin, John Bass, Fredric O Finkelstein, Steven M Gorbatkin
Peritoneal dialysis (PD) is a means of renal replacement therapy (RRT) that can be performed in remote settings with limited resources, including regions that lack electrical power. PD is a mainstay of end-stage renal disease (ESRD) therapy worldwide, and the ease of initiation and maintenance has enabled it to flourish in both resource-limited and resource-abundant settings. In natural disaster scenarios, military conflicts, and other austere areas, PD may be the only available life-saving measure for acute kidney injury (AKI) or ESRD...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29758424/using-strontium-isotopes-to-evaluate-the-spatial-variation-of-groundwater-recharge
#11
John N Christensen, Baptiste Dafflon, Alyssa E Shiel, Tetsu K Tokunaga, Jiamin Wan, Boris Faybishenko, Wenming Dong, Kenneth H Williams, Chad Hobson, Shaun T Brown, Susan S Hubbard
Recharge of alluvial aquifers is a key component in understanding the interaction between floodplain vadose zone biogeochemistry and groundwater quality. The Rifle Site (a former U-mill tailings site) adjacent to the Colorado River is a well-established field laboratory that has been used for over a decade for the study of biogeochemical processes in the vadose zone and aquifer. This site is considered an exemplar of both a riparian floodplain in a semiarid region and a post-remediation U-tailings site. In this paper we present Sr isotopic data for groundwater and vadose zone porewater samples collected in May and July 2013 to build a mixing model for the fractional contribution of vadose zone porewater (i...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757763/corr-insights%C3%A2-does-orthopaedic-outpatient-care-reduce-emergency-department-utilization-after-total-joint-arthroplasty
#12
Chad A Krueger
No abstract text is available yet for this article.
May 11, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29757428/micro-hotspots-of-risk-in-urban-cholera-epidemics
#13
Andrew S Azman, Francisco J Luquero, Henrik Salje, Nathan Naibei Mbaïbardoum, Ngandwe Adalbert, Mohammad Ali, Enrico Bertuzzo, Flavio Finger, Brahima Toure, Louis Albert Massing, Romain Ramazani, Bansaga Saga, Maya Allan, David Olson, Jerome Leglise, Klaudia Porten, Justin Lessler
Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and D.R. Congo we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200-meters during the 5-days immediately following case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings...
May 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29757066/reliability-and-clinical-feasibility-of-measuring-dual-task-gait-in-the-inpatient-rehabilitation-setting-following-traumatic-brain-injury
#14
Lauren Rachal, Chad Swank, Elaine Trudelle-Jackson, Simon Driver
BACKGROUND: To prepare patients with traumatic brain injury (TBI) for discharge from inpatient rehabilitation, physical therapists may incorporate dual-task gait activities. Reliability of common dual-task measures for people with TBI in inpatient rehabilitation is undetermined. Our purpose was to assess inter-rater and intra-rater reliability and clinical feasibility of dual-task measures [Walking While Talking Test (WWTT), Modified Walking and Remembering Task (mWART), Timed Up and Go-cognitive (TUG-COG)] in inpatient rehabilitation for patients with TBI...
May 14, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29755982/clinical-genetics-in-interstitial-lung-disease
#15
REVIEW
Chad A Newton, Philip L Molyneaux, Justin M Oldham
Interstitial lung disease (ILD) comprises a heterogeneous group of diffuse parenchymal lung processes with overlapping clinical, radiographic, and histopathologic features. Among the most common and deadly ILDs are idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (CHP). As the name implies, the cause of IPF remains elusive, but a variety of genetic and infectious risk factors have been identified. CHP results from chronic inhalation of an organic antigen, usually of avian or mold origin, and may occur in patients with a genetic predisposition...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29755449/immunization-elicits-antigen-specific-antibody-sequestration-in-dorsal-root-ganglia-sensory-neurons
#16
Manojkumar Gunasekaran, Prodyot K Chatterjee, Andrew Shih, Gavin H Imperato, Meghan Addorisio, Gopal Kumar, Annette Lee, John F Graf, Dan Meyer, Michael Marino, Christopher Puleo, Jeffrey Ashe, Maureen A Cox, Tak W Mak, Chad Bouton, Barbara Sherry, Betty Diamond, Ulf Andersson, Thomas R Coleman, Christine N Metz, Kevin J Tracey, Sangeeta S Chavan
The immune and nervous systems are two major organ systems responsible for host defense and memory. Both systems achieve memory and learning that can be retained, retrieved, and utilized for decades. Here, we report the surprising discovery that peripheral sensory neurons of the dorsal root ganglia (DRGs) of immunized mice contain antigen-specific antibodies. Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG1 subtype antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29754104/measuring-individual-level-needle-and-syringe-coverage-among-people-who-inject-drugs-in-myanmar
#17
Daniel O'Keefe, Soe Moe Aung, Naanki Pasricha, Thu Wun, Soe Khaing Linn, Nay Lin, Campbell Aitken, Chad Hughes, Paul Dietze
BACKGROUND: Myanmar has prioritised people who inject drugs (PWID) as a key population for HIV mitigation efforts, with targets for needle and syringe distribution set at a population level. However, individual-level coverage, defined as the percentage of an individual's injecting episodes covered by a sterile syringe, is a more sensitive measure of intervention coverage. We sought to examine individual-level coverage in a sample of PWID in Myanmar. METHODS: We recruited 512 PWID through urban drop-in-centres in Yangon, Mandalay and Pyin Oo Lwin...
May 10, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29752890/editorial-comment
#18
Chad Ritch, Heidi J Silver
No abstract text is available yet for this article.
May 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29750006/a-novel-integrated-cognitive-behavioral-therapy-for-anxiety-and-medication-adherence-among-persons-living-with-hiv-aids
#19
Charles P Brandt, Daniel J Paulus, Monica Garza, Chad Lemaire, Peter J Norton, Michael J Zvolensky
Persons living with HIV/AIDS (PLHIV) are able to live full lifespans after infection, however, rates of anxiety disorders among this population are elevated compared to national samples. Importantly, these anxiety symptoms and disorders have a negative effect on medication adherence, quality of life and other psychological disorders, such as depression. In order to reduce the impact of anxiety among PLHIV, a six-session transdiagnostic CBT-based treatment manual for anxiety among PLHIV named the HIV/Anxiety Management-Reduction Treatment (HAMRT) was developed and implemented...
February 2018: Cognitive and Behavioral Practice
https://www.readbyqxmd.com/read/29748040/cytogenetic-profile-of-moroccan-pediatric-acute-lymphoblastic-leukemia-analysis-of-155-cases-with-a-review-of-the-literature
#20
Zahra Takki Chebihi, Aziza Belkhayat, Elbekkay Chadli, Latifa Hilal, Hanaa Skhoun, Laila Hessissen, Mohamed El Khorassani, Maria El Kababri, Amina Kili, Mohammed Khattab, Youssef Bakri, Nadia Dakka
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, with a peak incidence at 2 to 3 years of age and accounting for almost 30% of all cancers in this age group. It is well established that the identification of cytogenetic abnormalities is highly relevant for the prognosis of and therapeutic decisions in ALL. The purpose of the present study was to define the frequency of recurrent chromosomal abnormalities of ALL in Moroccan patients referred exclusively to the BIOLAB Laboratory of the Children's Hospital of Rabat during a 4-year period and compare our findings to the reported data...
April 25, 2018: Clinical Lymphoma, Myeloma & Leukemia
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