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https://www.readbyqxmd.com/read/28748540/particulate-matter-pm-s-adheres-to-human-hair-exposed-to-severe-aerial-pollution-consequences-for-certain-hair-surface-properties
#1
Anthony Galliano, Chengda Ye, Fengjie Su, Chad Wang, Yin Wang, Chen Liu, Anupama Wagle, Myriam Guerin, Frédéric Flament, Andrew Steel
BACKGROUND: The deposit and adherence of particulate matter (PM's) from aerial pollution onto the surface of human hair is a poorly studied phenomenon. OBJECTIVES: i) To reproduce in vitro the deposit of known PM's on standardized hair swatches in a closed box, ii) to compare in vitro data with those obtained under "real life" conditions of severe aerial pollution, iii) to assess the changes of the hair surface properties, potentially caused by the adherence of airborne PM's onto the hair...
July 26, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28746088/the-harms-of-hiv-criminalization-responding-to-the-association-of-hiv-diagnosis-rates-and-laws-criminalizing-hiv-exposure-in-the-united-states
#2
Alexander McClelland, Martin French, Eric Mykhalovskiy, Marilou Gagnon, Eli Manning, Ryan Peck, Chad Clarke, Tim McCaskell
No abstract text is available yet for this article.
August 24, 2017: AIDS
https://www.readbyqxmd.com/read/28745944/need-to-screen-for-clinical-levels-of-ocd-four-questions-are-the-key
#3
Judy H Hong, Eric B Lee, Chad T Wetterneck, John M Hart
The aim of this study was to investigate a new measure, the Wetterneck-Hart OCD Screener (WHOS), as a self-report screening tool for obsessive-compulsive disorder (OCD). The authors examined relationships between the WHOS and severity scores of OCD measures taken via three methods of data collection: online, at OCD consumer conferences, and from an intensive, residential OCD program. Severity measures included the Yale-Brown Obsessive-Compulsive Scale-Self Report (Y-BOCS-SR), the Dimensional Obsessive-Compulsive Scale (DOCS), and the Obsessive-Compulsive Inventory-Revised (OCI-R)...
July 26, 2017: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/28745930/what-does-the-eggshell-cuticle-do-a-functional-comparison-of-avian-eggshell-cuticles
#4
Liliana D'Alba, Roxana Torres, Geoffrey I N Waterhouse, Chad Eliason, Mark E Hauber, Matthew D Shawkey
The avian eggshell is a highly ordered structure with several layers (mammillae, palisades, and vertical crystal layer) composed of calcium carbonate (∼96%) and minerals within an organic matrix. The cuticle is a noncalcified layer that covers the eggshells of most bird species. Eggshells are multifunctional structures that have evolved in response to diverse embryonic requirements and challenges, including protection from microbial infection, nest flooding, and exposure to solar radiation. However, experimental evidence for these functions across diverse taxa is currently limited...
September 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28745033/psychometric-investigation-of-the-specific-phobia-of-vomiting-inventory-a-new-factor-model
#5
Danielle J Maack, Chad Ebesutani, Todd A Smitherman
Well-validated, standardized measures are lacking for the assessment of emetophobia, the specific phobia of vomiting. The Specific Phobia of Vomiting Inventory (SPOVI) was recently developed and shows promise as a useful measure of emetophobia. The goal of the present study was to further examine and investigate the psychometric properties of the SPOVI in a large student sample (n = 1626), specifically focusing on its factor structure, measurement invariance across gender, and convergent/divergent validity...
July 25, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28744705/the-growth-of-hospitalists-and-the-future-of-the-society-of-general-internal-medicine-results-from-the-2014-membership-survey
#6
Chad S Miller, Robert L Fogerty, Jillian Gann, Christopher P Bruti, Robin Klein
According to the most recent annual membership surveys, hospitalists are a rapidly growing component of the Society of General Internal Medicine (SGIM). Should this trend continue, hospitalists could increase from 22% of SGIM membership in 2014 to nearly 33% by 2020. Only 34% of hospitalists who responded to the survey, however, consider SGIM their academic home, compared to 54% of non-hospitalist respondents. Based on these survey findings, it is clear that the landscape of general internal medicine is changing with the growth of hospitalists, and SGIM will need to strategize to keep these hospitalist members actively engaged in the organization...
July 25, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28744021/thy-1-cancer-associated-fibroblasts-adversely-impact-lung-cancer-prognosis
#7
Mark J Schliekelman, Chad J Creighton, Brandi N Baird, Yulong Chen, Priyam Banerjee, Neus Bota-Rabassedas, Young-Ho Ahn, Jonathon D Roybal, Fengju Chen, Yiqun Zhang, Dhruva K Mishra, Min P Kim, Xin Liu, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio I Wistuba, Samir M Hanash, Jonathan M Kurie
Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1 (CD90) marks CAFs that promote tumor cell invasion in a murine model of Kras(G12D)-driven lung adenocarcinoma (Kras(LA1)), here we postulated that human lung adenocarcinomas containing Thy-1(+) CAFs have a worse prognosis. We first examined the location of Thy-1(+) CAFs within human lung adenocarcinomas...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743761/naturally-segregating-variation-at-ugt86dd-contributes-to-nicotine-resistance-in-drosophila-melanogaster
#8
Chad A Highfill, Jonathan H Tran, Samantha K T Nguyen, Taylor R Moldenhauer, Xiaofei Wang, Stuart J Macdonald
Identifying the sequence polymorphisms underlying complex trait variation is a key goal of genetics research, since knowing the precise causative molecular events allows insight into the pathways governing trait variation. Genetic analysis of complex traits in model systems regularly starts by constructing QTL maps, but generally fails to identify causative sequence polymorphisms. Previously we mapped a series of QTL contributing to resistance to nicotine in a Drosophila melanogaster multiparental mapping resource, and here use a battery of functional tests to resolve QTL to the molecular level...
July 25, 2017: Genetics
https://www.readbyqxmd.com/read/28741332/willingness-to-use-hiv-pre-exposure-prophylaxis-among-gay-men-other-men-who-have-sex-with-men-and-transgender-women-in-myanmar
#9
Bridget L Draper, Zaw Min Oo, Zaw Win Thein, Poe Poe Aung, Vanessa Veronese, Claire Ryan, Myo Thant, Chad Hughes, Mark Stoové
INTRODUCTION: HIV pre-exposure prophylaxis (PrEP) has emerged as a key component of contemporary HIV combination prevention strategies. To explore the local suitability of PrEP, country-specific acceptability studies are needed to inform potential PrEP implementation. In the context of Myanmar, in addition to resource constraints, HIV service access by gay men, other men who have sex with men, and transgender women (GMT) continues to be constrained by legislative and community stigma and marginalization...
July 26, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28740609/simple-tetrahydroisoquinolines-are-potent-and-selective-kappa-opioid-receptor-antagonists
#10
Chad M Kormos, Pauline W Ondachi, Scott P Runyon, James B Thomas, S Wayne Mascarella, Ann M Decker, Hernán A Navarro, F Ivy Carroll
Potent and selective κ opioid receptor antagonists have been derived from the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of pure opioid receptor antagonists. In order to determine if the 3-hydroxyphenyl and/or the piperidine amino groups are required for obtaining the pure opioid antagonists, (3R)-7-hydroxy-N-[(1S)-2-methyl-1-(piperidine-1-ylmethyl)propyl]-1,2,3,4-tetrahydroiosquinoline-3-carboxamide (1), which does not have a 4-(3-hydroxyphenyl) group, and (3R)-N-(1R)-1-(cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (2), which does not have a 4-hydroxylphenyl or a piperidine amino group, were synthesized and evaluated for their [(35)S]GTPγS binding properties at the μ, δ, and κ opioid receptors...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28739801/sustained-o-glcnacylation-reprograms-mitochondrial-function-to-regulate-energy-metabolism
#11
Ee Phie Tan, Steven R McGreal, Stefan Graw, Robert Tessman, Scott J Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E Zachara, Devin C Koestler, Kenneth R Peterson, John P Thyfault, Russell H Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, Chad Slawson
Dysfunctional mitochondria and generation of reactive oxygen species (ROS) promote chronic diseases, which have spurred interest in the molecular mechanisms underlying these conditions. Previously, we have demonstrated that disruption of post-translational modification of proteins with β-linked N-acetylglucosamine (O-GlcNAcylation) via overexpression of the O-GlcNAc regulating enzymes O-GlcNAc transferase (OGT) or O-GlcNAcase (OGA) impairs mitochondrial function. Here, we report that sustained alterations in O-GlcNAcylation either by pharmacological or genetic manipulation also alters metabolic function...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28736901/food-waste-conversion-to-microbial-polyhydroxyalkanoates
#12
REVIEW
Chad Nielsen, Asif Rahman, Asad Ur Rehman, Marie K Walsh, Charles D Miller
Polyhydroxyalkanoates (PHAs) are biopolymers with desirable material properties similar to petrochemically derived plastics. PHAs are naturally produced by a wide range of microorganisms as a carbon storage mechanism and can accumulate to significantly high levels. PHAs are an environmentally friendly alternative to their petroleum counterparts because they can be easily degraded, potentially reducing the burden on municipal waste systems. Nevertheless, widespread use of PHAs is not currently realistic due to a variety of factors...
July 24, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28736286/lack-of-immunotoxic-effects-of-repeated-exposure-to-atrazine-associated-with-the-adaptation-of-adrenal-gland-activation
#13
Chad D Foradori, Arthur D Zimmerman, Pragati S Coder, Vanessa L Peachee, Robert J Handa, Ian Kimber, Stephen B Pruett, Charles B Breckenridge
T cell-dependent IgM antibody production and natural killer cell (NKC) activity were assessed in SD rats orally administered atrazine for 28 days to males (0, 6.5, 25, or 100 mg/kg/day) or females (0, 3, 6, or 50 mg/kg/day), or 30 or 500 ppm in diet (3 or 51 mg/kg/day). Anti-asialo GM1 antibodies (NKC) and cyclophosphamide (antibody-forming cell [AFC]) assays served as positive controls. Pituitary (ACTH, prolactin), adrenal (corticosterone, progesterone, aldosterone), and gonadal (androgens, estrogens) hormones were assessed after 1, 7, and/or 28 days of treatment...
July 20, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28735641/risk-and-resilience-brain-networks-in-treatment-resistant-schizophrenia
#14
Eleni P Ganella, Caio Seguin, Cali F Bartholomeusz, Sarah Whittle, Chad Bousman, Cassandra M J Wannan, Maria A Di Biase, Christina Phassouliotis, Ian Everall, Christos Pantelis, Andrew Zalesky
BACKGROUND: Genes, molecules and neural circuits that are associated with, or confer risk to developing schizophrenia have been studied and mapped. It is hypothesized that certain neural systems may counterbalance familial risk of schizophrenia, and thus confer resilience to developing the disorder. This study sought to identify resting-state functional brain connectivity (rs-FC) representing putative risk or resilience endophenotypes in schizophrenia. METHODS: Resting-state functional magnetic resonance imaging (rs-fMRI) was performed in 42 individuals with treatment resistant schizophrenia (TRS), 16 unaffected first-degree family members (UFM) and 42 healthy controls...
July 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28732826/corrigendum-to-a-multicenter-randomized-double-blind-dose-ranging-study-of-glycopyrrolate-formoterol-fumarate-fixed-dose-combination-metered-dose-inhaler-compared-to-the-monocomponents-and-open-label-tiotropium-dry-powder-inhaler-in-patients-with-moderate-to
#15
Donald P Tashkin, Fernando J Martinez, Roberto Rodriguez-Roisin, Charles Fogarty, Mark Gotfried, Michael Denenberg, Gregory Gottschlich, James F Donohue, Chad Orevillo, Patrick Darken, Earl St Rose, Shannon Strom, Tracy Fischer, Michael Golden, Colin Reisner
No abstract text is available yet for this article.
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732212/ualcan-a-portal-for-facilitating-tumor-subgroup-gene-expression-and-survival-analyses
#16
Darshan S Chandrashekar, Bhuwan Bashel, Sai Akshaya Hodigere Balasubramanya, Chad J Creighton, Israel Ponce-Rodriguez, Balabhadrapatruni V S K Chakravarthi, Sooryanarayana Varambally
Genomics data from The Cancer Genome Atlas (TCGA) project has led to the comprehensive molecular characterization of multiple cancer types. The large sample numbers in TCGA offer an excellent opportunity to address questions associated with tumo heterogeneity. Exploration of the data by cancer researchers and clinicians is imperative to unearth novel therapeutic/diagnostic biomarkers. Various computational tools have been developed to aid researchers in carrying out specific TCGA data analyses; however there is need for resources to facilitate the study of gene expression variations and survival associations across tumors...
July 18, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28731353/altering-dna-programmable-colloidal-crystallization-paths-by-modulating-particle-repulsion
#17
Mary X Wang, Jeffrey D Brodin, Jaime A Millan, Soyoung E Seo, Martin Girard, Monica Olvera de la Cruz, Byeongdu Lee, Chad A Mirkin
Colloidal crystal engineering with DNA can be used to realize precise control over nanoparticle (NP) arrangement. Here, we investigate a case of DNA-based assembly where the properties of DNA as a polyelectrolyte brush are employed to alter a hybridization-driven NP crystallization pathway. Using the coassembly of DNA-conjugated proteins and spherical gold nanoparticles (AuNPs) as a model system, we explore how steric repulsion between noncomplementary, neighboring NPs due to overlapping DNA shells can influence their ligand-directed behavior...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28731332/tuning-the-cavity-size-and-chirality-of-self-assembling-3d-dna-crystals
#18
Chad R Simmons, Fei Zhang, Tara MacCulloch, Nour Eddine Fahmi, Nicholas Stephanopoulos, Yan Liu, Nadrian C Seeman, Hao Yan
The foundational goal of structural DNA nanotechnology-the field that uses oligonucleotides as a molecular building block for the programmable self-assembly of nanostructured systems-was to use DNA to construct three-dimensional (3D) lattices for solving macromolecular structures. The programmable nature of DNA makes it an ideal system for rationally constructing self-assembled crystals, and immobilizing guest molecules in a repeating 3D array through their specific stereospatial interactions with the scaffold...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28727924/does-early-change-predict-long-term-6-months-improvements-in-subjects-who-receive-manual-therapy-for-low-back-pain
#19
Chad Cook, Shannon Petersen, Megan Donaldson, Mark Wilhelm, Ken Learman
Early change is commonly assessed for manual therapy interventions and has been used to determine treatment appropriateness. However, current studies have only explored the relationship of between or within-session changes and short-/medium-term outcomes. The goal of this study was to determine whether pain changes after two weeks of pragmatic manual therapy could predict those participants with chronic low back pain who demonstrate continued improvements at 6-month follow-up. This study was a retrospective observational design...
July 20, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28727699/efficacy-of-palmitoylethanolamide-for-pain-a-meta-analysis
#20
Bekir Berker Artukoglu, Chad Beyer, Adi Zuloff-Shani, Ephraim Brener, Michael Howard Bloch
BACKGROUND: Palmitoylethanolamide (PEA) is a cannabimimetic compound that has been investigated as an analgesic agent in animal models and clinical trials. OBJECTIVES: We conducted a meta-analysis to examine the efficacy of PEA for treating pain in randomized, controlled trials. STUDY DESIGN: Systematic review and meta-analysis. SETTING: This meta-analysis examined all randomized, controlled trials involving the effect of PEA on pain score...
July 2017: Pain Physician
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