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https://www.readbyqxmd.com/read/28088553/the-influence-of-landmark-stability-on-control-by-occasion-setters
#1
REVIEW
Lauren M Cleland, Chad M Ruprecht, Ronnie V Lee, Kenneth J Leising
In an operant serial feature-positive procedure, an occasion setter (OSX) signals that a response will be reinforced in the presence of second stimulus (e.g., a discriminative stimulus, A). During a transfer test, the OS is paired with a different discriminative stimulus. Experiment 1a tested transfer effects in a touchscreen-based spatial occasion setting task with pigeons. During training, four OSs (OSW, OSX, OSY, and OSZ) were paired on separate trials with landmark A (LMA) or B (LMB) and the opportunity for a reinforced response one location to the immediate left (R1) or right (R2) of the LM (OSW→LMA:R1, OSX→LMA:R2, OSY→LMB:R1, OSZ→LMB:R2)...
January 11, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28087162/mir-24-inhibition-increases-menin-expression-and-decreases-cholangiocarcinoma-proliferation
#2
Laurent Ehrlich, Chad Hall, Julie Venter, David Dostal, Francesca Bernuzzi, Pietro Invernizzi, Fanyin Meng, Jerome P Trzeciakowski, Tianhao Zhou, Holly Standeford, Gianfranco Alpini, Terry C Lairmore, Shannon Glaser
Menin (MEN1) is a tumor-suppressor protein in neuroendocrine tissue. Because cholangiocytes can take on a neuroendocrine phenotype, we tested the novel hypothesis that menin regulates cholangiocarcinoma proliferation. Menin and miR-24 expression levels were measured in the following intrahepatic and extrahepatic cholangiocarcinoma (CCA) cell lines, Mz-ChA-1, TFK-1, SG231, CCLP, HuCCT-1, and HuH-28, as well as the nonmalignant human intrahepatic biliary line, H69. miR-24 miRNA and menin protein levels were manipulated in vitro in Mz-ChA-1 cell lines...
January 10, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28078106/advances-in-cholangiocarcinoma-research-report-from-the-third-cholangiocarcinoma-foundation-annual-conference
#3
Ghassan K Abou-Alfa, Jesper B Andersen, William Chapman, Michael Choti, Stuart J Forbes, Gregory J Gores, Theodore S Hong, James J Harding, Matthew G Vander Heiden, Milind Javle, Robin K Kelley, Lawrence N Kwong, Maeve Lowery, Allyson Merrell, Katsuyuki Miyabe, Andrew Rhim, Supriya Saha, Daniela Sia, Suebpong Tanasanvimon, Alan Venook, Juan W Valle, Chad Walesky, Jonathan Whetstine, Holger Willenbring, Andrew X Zhu, Donna Mayer, Ben Z Stanger
No abstract text is available yet for this article.
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077705/processing-of-intraoral-olfactory-and-gustatory-signals-in-the-gustatory-cortex-of-awake-rats
#4
Chad L Samuelsen, Alfredo Fontanini
: The integration of gustatory and olfactory information is essential to the perception of flavor. Human neuroimaging experiments have pointed to the gustatory cortex (GC) as one of the areas involved in mediating flavor perception. Although GC's involvement in encoding the chemical identity and hedonic value of taste stimuli is well studied, it is unknown how single GC neurons process olfactory stimuli emanating from the mouth. In this study, we relied on multielectrode recordings to investigate how single GC neurons respond to intraorally delivered tastants and tasteless odorants dissolved in water and whether/how these two modalities converge in the same neurons...
January 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28075619/role-of-ct-in-the-diagnosis-of-nonspecific-abdominal-pain-a-multicenter-analysis
#5
Jonathan D Eisenberg, Andrew T Reisner, William D Binder, Atif Zaheer, Martin L Gunn, Ken F Linnau, Chad M Miller, Angela C Tramontano, Maurice S Herring, Emily C Dowling, Elkan F Halpern, Karen Donelan, G Scott Gazelle, Pari V Pandharipande
OBJECTIVE: The objective of our study was to determine whether specific patient and physician factors-known before CT-are associated with a diagnosis of nonspecific abdominal pain (NSAP) after CT in the emergency department (ED). MATERIALS AND METHODS: We analyzed data originally collected in a prospective multicenter study. In the parent study, we identified ED patients referred to CT for evaluation of abdominal pain. We surveyed their physicians before and after CT to identify changes in leading diagnoses, diagnostic confidence, and admission decisions...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28074468/do-changes-in-mitochondrial-quality-contribute-to-increases-in-skeletal-muscle-oxidative-capacity-following-endurance-training
#6
Miles F Bartlett, Julia D Miehm, Liam F Fitzgerald, Chad R Straight
Endurance training improves skeletal muscle oxidative capacity, but the molecular adaptations that drive this process are not fully understood. This article is protected by copyright. All rights reserved.
January 11, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28073724/follow-the-reporter-from-the-african-world-who-travelled-4000-km-from-the-coast-of-senagal-to-lake-chad-to-meet-the-women-of-the-sahel
#7
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28073713/the-french-muskoka%C3%A2-fund-origin-objectives-and-implementation
#8
S Aboubaker, C Grimaldi
Through its Priority Solidarity Fund, France set up a partnership with four United Nations agencies, WHO, UNICEF, UNFPA, and UN WOMEN for the years 2011-2015 with an annual budget of 19 M €. An additional sixth year supplementary is underway. The program was developed through a common framework of actions coordinated and harmonized at the level of the target countries: integrated management of childhood diseases, mother-child nutrition, prenatal, perinatal, and postpartum follow-up, sexual and reproductive health, and adolescent health...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28073459/vertical-migration-of-karenia-brevis-in-the-northeastern-gulf-of-mexico-observed-from-glider-measurements
#9
Chuanmin Hu, Brian B Barnes, Lin Qi, Chad Lembke, David English
The toxic marine dinoflagellate, Karenia brevis (the species responsible for most of red tides or harmful algal blooms in the Gulf of Mexico), is known to be able to swim vertically to adapt to the light and nutrient environments, nearly all such observations have been made through controlled experiments using cultures. Here, using continuous 3-dimensional measurements by an ocean glider across a K. brevis bloom in the northeastern Gulf of Mexico between 1 and 8 August 2014, we show the vertical migration behavior of K...
September 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073171/pan-cancer-survey-of-epithelial-mesenchymal-transition-markers-across-the-cancer-genome-atlas
#10
Don L Gibbons, Chad J Creighton
BACKGROUND: While epithelial-mesenchymal transition (EMT) can be readily induced experimentally in cancer cells, the EMT process as manifested in human tumors needs to be better understood. Pan-cancer genomic datasets from The Cancer Genome Atlas (TCGA)-representing over 10,000 patients and 32 distinct cancer types-provide a rich resource for examining correlative patterns involving EMT mediators in the setting of human cancers. RESULTS: Here, we surveyed a 16-gene signature of canonical EMT markers in TCGA pan-cancer cohort...
January 10, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28071898/abnormal-multiple-charge-memory-states-in-exfoliated-few-layer-wse2-transistors
#11
Mikai Chen, Yifan Wang, Nathan Shepherd, Chad Huard, Jiantao Zhou, L J Guo, Wei Lu, Xiaogan Liang
To construct reliable nanoelectronic devices based on emerging 2D layered semiconductors, we need to understand the charge-trapping processes in such devices. Additionally, the identified charge-trapping schemes in such layered materials could be further exploited to make multibit (or highly desirable analog-tunable) memory devices. Here, we present a study on the abnormal charge-trapping or memory characteristics of few-layer WSe2 transistors. This work shows that multiple charge-trapping states with large extrema spacing, long retention time, and analog tunability can be excited in the transistors made from mechanically exfoliated few-layer WSe2 flakes, whereas they cannot be generated in widely studied few-layer MoS2 transistors...
January 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28070875/atrial-fibrillation-inducibility-during-cavotricuspid-isthmus-dependent-atrial-flutter-ablation-as-a-predictor-of-clinical-atrial-fibrillation-a-meta-analysis
#12
Jorge Romero, Juan Carlos Diaz, Luigi Di Biase, Saurabh Kumar, David Briceno, Usha B Tedrow, Carolina R Valencia, Samuel H Baldinger, Bruce Koplan, Laurence M Epstein, Roy John, Gregory F Michaud, William G Stevenson
BACKGROUND: Atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) are two separate entities that coexist in a significant percentage of patients. We sought to investigate whether AF inducibility during CTI AFL ablation predicted the occurrence of AF at follow-up after successful AFL ablation. METHODS: A systemic review of Medline, Cochrane, and Embase was done for all the clinical studies in which assessment of AF inducibility in patients undergoing ablation for CTI AFL was performed...
January 9, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28069942/a-paradox-of-transcriptional-and-functional-innate-interferon-responses-of-human-intestinal-enteroids-to-enteric-virus-infection
#13
Kapil Saxena, Lukas M Simon, Xi-Lei Zeng, Sarah E Blutt, Sue E Crawford, Narayan P Sastri, Umesh C Karandikar, Nadim J Ajami, Nicholas C Zachos, Olga Kovbasnjuk, Mark Donowitz, Margaret E Conner, Chad A Shaw, Mary K Estes
The intestinal epithelium can limit enteric pathogens by producing antiviral cytokines, such as IFNs. Type I IFN (IFN-α/β) and type III IFN (IFN-λ) function at the epithelial level, and their respective efficacies depend on the specific pathogen and site of infection. However, the roles of type I and type III IFN in restricting human enteric viruses are poorly characterized as a result of the difficulties in cultivating these viruses in vitro and directly obtaining control and infected small intestinal human tissue...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28069418/splenic-artery-aneurysm-rupture-in-pregnancy
#14
Joshua Jacobson, Chad Gorbatkin, Stacey Good, Scott Sullivan
CASE PRESENTATION: A pregnant woman at 22+5/7weeks gestation presented to the emergency department (ED) from an outpatient clinic, hypotensive after experiencing a syncopal episode. On arrival to the ER she was tachycardic, tachypneic and complaining of abdominal pain. A bedside FAST was performed and noted free fluid in the abdomen. Subsequent CT obtained noted the rare but life-threatening diagnosis of ruptured splenic artery aneurysm that resulted in emergent transfer to the operating room with OB/GYN and general surgery...
December 15, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28068791/the-utilization-of-antithrombotic-therapy-in-older-patients-in-aged-care-facilities-with-atrial-fibrillation
#15
Bridget Frain, Ronald Castelino, Luke R Bereznicki
Oral anticoagulants are essential drugs for the prevention of thromboembolic events in patients with atrial fibrillation (AF). Anticoagulants are, however, commonly withheld in older people due to the risk and fear of hemorrhage. Although the underutilization of anticoagulants in patients with AF has been demonstrated internationally, few studies have been conducted among aged care residents. The aim of this study was to determine the utilization of anticoagulants among people with AF residing in aged care facilities...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28066911/outcomes-of-microvascular-free-tissue-transfer-in-twice-irradiated-patients
#16
Kate Clancy, Sami Melki, Musaddiq Awan, Shawn Li, Pierre Lavertu, Nicole Fowler, Min Yao, Rod Rezaee, Chad A Zender
BACKGROUND: Patients may require microvascular free tissue transfer (MFTT) following re-irradiation for recurrent cancer or radiation complications. The objective of this study was to describe the indications for and outcomes of free flaps performed in twice-radiated patients. METHODS: A retrospective chart review identified the indications for and outcomes of 36 free flaps performed on 29 twice-irradiated patients. RESULTS: The free flap success rate was 92%...
January 9, 2017: Microsurgery
https://www.readbyqxmd.com/read/28066581/pd-l1-expression-in-lung-cancer
#17
EDITORIAL
Chad Tang, Joe Y Chang
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28064035/a-ranking-system-for-prescribed-burn-prioritization-in-table%C3%A2-mountain-national-park-south-africa
#18
Carly Ruth Cowell, Chad Cheney
To aid prescribed burn decision making in Table Mountain National Park, in South Africa a priority ranking system was tested. Historically a wildfire suppression strategy was adopted due to wildfires threatening urban areas close to the park, with few prescribed burns conducted. A large percentage of vegetation across the park exceeded the ecological threshold of 15 years. We held a multidisciplinary workshop, to prioritize areas for prescribed burning. Fire Management Blocks were mapped and assessed using the following seven categories: (1) ecological, (2) management, (3) tourism, (4) infrastructure, (5) invasive alien vegetation, (6) wildland-urban interface and (7) heritage...
January 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28063990/efficient-tuning-of-sirna-dose-response-by-combining-mixed-polymer-nanocarriers-with-simple-kinetic-modeling
#19
Chad T Greco, Victoria G Muir, Thomas H Epps Iii, Millicent O Sullivan
: Two of the most prominent challenges that limit the clinical success of siRNA therapies are a lack of control over cargo release from the delivery vehicle and an incomplete understanding of the link between gene silencing dynamics and siRNA dosing. Herein, we address these challenges through the formulation of siRNA polyplexes containing light-responsive polymer mixtures, whose varied compositions and triggered release behavior provide enhanced gene silencing and controlled dose responses that can be predicted by simple kinetic models...
January 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28062542/phenobarbital-treatment-at-a-neonatal-age-results-in-decreased-efficacy-of-omeprazole-in-adult-mice
#20
Yun-Chen Tien, Stephanie C Piekos, Chad Pope, Xiao-Bo Zhong
Drug-drug interactions (DDIs) occur when the action of one drug interferes with or alters the activity of another drug taken concomitantly. This can lead to decreased drug efficacy or increased toxicity. Because of DDIs, physicians in the clinical practice attempt to avoid potential interactions when multiple drugs are co-administrated, however there is still a large knowledge gap in understanding how drugs taken in the past can contribute to DDIs in the future. The goal of this study is to investigate the consequence of neonatal drug exposure on efficacy of other drugs administered to adult life...
January 6, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
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