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https://www.readbyqxmd.com/read/29584904/combined-pathologies-in-ftld-tdp-types-a-and-c
#1
Tamar Gefen, Saman S Ahmadian, Qinwen Mao, Garam Kim, Mustafa Seckin, Borna Bonakdarpour, Eliana Marisa Ramos, Giovanni Coppola, Rosa Rademakers, Emily Rogalski, Alfred Rademaker, Sandra Weintraub, M-Marsel Mesulam, Changiz Geula, Eileen H Bigio
This study investigated the presence of combined pathologies in a large cohort of autopsies that show a primary pathologic diagnosis of phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP), the majority of which portrayed clinical phenotypes consistent with primary progressive aphasia or behavioral variant frontotemporal dementia (bvFTD). Thirty-eight cases with FTLD-TDP (30 type-A and 8 type-C) were identified to determine characteristic differences between cases with and without combined pathologies. Findings indicated that combined pathologies co-occur with FTLD-TDP type-A at a high frequency (50%)-greater than when compared to FTLD-TDP type-C cases (12...
March 23, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29519965/-social-systems-and-resources-for-people-with-dementia
#2
Yukihiko Washimi
In the Clinical Guidelines for Dementia 2017, the strategies to support persons with dementia and their families have increased significantly. This article provides a comprehensive and concise explanation of the importance of the newly launched systems and social resources. A new Five-Year Plan for promotion of Dementia Measures ("New Orange Plan") supports the realization of a society where persons with dementia are able to live with dignity as long as possible. New Medical Centers for Dementia provide specialized medical services and integrate community resources for building a comprehensive support network for persons with dementia...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29487403/use-of-an-alzheimer-s-disease-polygenic-risk-score-to-identify-mild-cognitive-impairment-in-adults-in-their-50s
#3
Mark W Logue, Matthew S Panizzon, Jeremy A Elman, Nathan A Gillespie, Sean N Hatton, Daniel E Gustavson, Ole A Andreassen, Anders M Dale, Carol E Franz, Michael J Lyons, Michael C Neale, Chandra A Reynolds, Xin Tu, William S Kremen
Early identification of younger, non-demented adults at elevated risk for Alzheimer's disease (AD) is crucial because the pathological process begins decades before dementia onset. Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who were only in their 50s. Participants were 1176 white, non-Hispanic community-dwelling men of European ancestry in the Vietnam Era Twin Study of Aging (VETSA): 7% with amnestic MCI (aMCI); 4% with non-amnestic MCI (naMCI)...
February 27, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29482653/physical-activity-for-people-with-young-onset-dementia-and-carers-protocol-for-a-scoping-review
#4
Chloe Rodgers, David Rogerson, Judy Stevenson, Davina Porock
BACKGROUND: Physical activity has been cited as a potential symptomatic treatment option for people living with dementia. At present, much of the research concerning physical activity and dementia considers older adults, and there are several review articles summarising the evidence in this area. Less is known about physical activity for younger people with dementia, despite the marked differences in needs and preferences between the two groups. The aim of this scoping review is to systematically explore and critically appraise the current state of the evidence regarding physical activity for people with young-onset dementia and carers...
February 27, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29466804/phenotypic-variability-in-autosomal-dominant-familial-alzheimer-disease-due-to-the-s170f-mutation-of-presenilin-1
#5
Hannes O Tiedt, Beate Benjamin, Michael Niedeggen, Andreas Lueschow
BACKGROUND: In rare cases, patients with Alzheimer disease (AD) present at an early age and with a family history suggestive of an autosomal dominant mode of inheritance. Mutations of the presenilin-1 (PSEN1) gene are the most common causes of dementia in these patients. Early-onset and particularly familial AD patients frequently present with variable non-amnestic cognitive symptoms such as visual, language or behavioural changes as well as non-cognitive, e.g. motor, symptoms. OBJECTIVE: To investigate the phenotypic variability in carriers of the PSEN1 S170F mutation...
February 22, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29435558/association-between-amyloid-and-tau-accumulation-in-young-adults-with-autosomal-dominant-alzheimer-disease
#6
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnson
Importance: It is critically important to improve our ability to diagnose and track Alzheimer disease (AD) as early as possible. Individuals with autosomal dominant forms of AD can provide clues as to which and when biological changes are reliably present prior to the onset of clinical symptoms. Objective: To characterize the associations between amyloid and tau deposits in the brains of cognitively unimpaired and impaired carriers of presenilin 1 (PSEN1) E280A mutation...
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29378790/features-of-gba-associated-parkinson-s-disease-at-presentation-in-the-uk-tracking-parkinson-s-study
#7
Naveed Malek, Rimona S Weil, Catherine Bresner, Michael A Lawton, Katherine A Grosset, Manuela Tan, Nin Bajaj, Roger A Barker, David J Burn, Thomas Foltynie, John Hardy, Nicholas W Wood, Yoav Ben-Shlomo, Nigel W Williams, Donald G Grosset, Huw R Morris
OBJECTIVES: To examine the influence of the glucocerebrosidase (GBA) mutation carrier state on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at baseline assessment in a large cohort of UK patients. We also analysed the prevalence of mood and behavioural problems that may confound the assessment of cognitive function. METHODS: We prospectively recruited patients with PD in the Tracking Parkinson's study. We fully sequenced the GBA gene in all recently diagnosed patients (≤3...
January 29, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29346380/rapidly-progressive-dementia-an-eight-year-2008-2016-retrospective-study
#8
Patil Anuja, Vishnu Venugopalan, Naheed Darakhshan, Pandit Awadh, Vinny Wilson, Goyal Manoj, Modi Manish, Lal Vivek
BACKGROUND AND PURPOSE: Rapidly progressive dementia (RPD) is an emergency in cognitive neurology, defined as cognitive impairment affecting the daily living activities developed over less than 1 year. This study investigated the profile of patients with rapidly progressive dementia at first presentation. METHODS: Retrospective case analysis was done in 187 patients with rapidly progressive dementia who presented to the Postgraduate Institute of Medical Education and Research, Chandigarh, India from January 2008 to August 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29336840/heterozygous-tyrobp-deletion-plosl-fin-is-not-a-strong-risk-factor-for-cognitive-impairment
#9
Karri Kaivola, Lilja Jansson, Elmo Saarentaus, Anna Kiviharju, Ville Rantalainen, Johan G Eriksson, Timo E Strandberg, Tuomo Polvikoski, Liisa Myllykangas, Pentti J Tienari
Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's disease when heterozygous. Here, we studied the PLOSLFIN TYROBP deletion that covers 4 of the gene's 5 exons. We genotyped 3220 older Finns (mean age 79, range 58-104) and found 11 deletion carriers (mean age 78, range 60-94)...
April 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29284406/an-additive-effect-of-leading-role-in-the-organization-between-social-participation-and-dementia-onset-among-japanese-older-adults-the-ages-cohort-study
#10
Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao, Katsunori Kondo
BACKGROUND: Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis remains largely unknown. The purpose of the present study was to examine the additive effect of a leadership position in the organization on dementia onset and social participation among elderly people in a local community, according to data from a Japanese older adults cohort study...
December 29, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29228201/widespread-brain-tau-and-its-association-with-ageing-braak-stage-and-alzheimer-s-dementia
#11
Val J Lowe, Heather J Wiste, Matthew L Senjem, Stephen D Weigand, Terry M Therneau, Bradley F Boeve, Keith A Josephs, Ping Fang, Mukesh K Pandey, Melissa E Murray, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Michelle M Mielke, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Clifford R Jack
See Herholz (doi:10.1093/brain/awx340) for a scientific commentary on this article.Autopsy data have proposed that a topographical pattern of tauopathy occurs in the brain with the development of dementia due to Alzheimer's disease. We evaluated the findings of tau-PET to better understand neurofibrillary tangle development as it is seen in cognitively unimpaired and impaired individuals. The evolution of Alzheimer's disease tauopathy in cognitively unimpaired individuals needs to be examined to better understand disease pathogenesis...
January 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29185371/recent-advances-in-longitudinal-structural-neuroimaging-of-younger-onset-dementias
#12
Ramon Landin-Romero, Olivier Piguet
No abstract text is available yet for this article.
December 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29159043/neuroimaging-and-other-modalities-to-assess-alzheimer-s-disease-in-down-syndrome
#13
REVIEW
Natalie Neale, Concepcion Padilla, Luciana Mascarenhas Fonseca, Tony Holland, Shahid Zaman
People with Down syndrome (DS) develop Alzheimer's disease (AD) at higher rates and a younger age of onset compared to the general population. As the average lifespan of people with DS is increasing, AD is becoming an important health concern in this group. Neuroimaging is becoming an increasingly useful tool in understanding the pathogenesis of dementia development in relation to clinical symptoms. Furthermore, neuroimaging has the potential to play a role in AD diagnosis and monitoring of therapeutics. This review describes major recent findings from in vivo neuroimaging studies analysing DS and AD via ligand-based positron emission tomography (PET), [18F] fluorodeoxyglucose (FDG)-PET, structural magnetic resonance imaging (sMRI), and diffusion tensor imaging (DTI)...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29154268/patient-characteristics-and-outcomes-associated-with-receiving-an-earlier-versus-later-diagnosis-of-probable-alzheimer-s-disease
#14
Noam Y Kirson, J Scott Andrews, Urvi Desai, Sarah B King, Sophie Schonfeld, Howard G Birnbaum, Daniel E Ball, Kristin Kahle-Wrobleski
BACKGROUND: Effectiveness of Alzheimer's disease (AD) treatments may depend critically on the timeliness of intervention. OBJECTIVE: To compare characteristics and outcomes of patients diagnosed with probable AD (prAD) based on time elapsed from first onset of cognitive decline. METHODS: Patients with ≥1 prAD diagnosis and ≥1 follow-up visit were selected from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS; 9/2005-6/2015) and stratified based on the time between the perceived onset of cognitive decline at baseline and first prAD diagnosis (i...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29102243/tau-amyloid-and-cascading-network-failure-across-the-alzheimer-s-disease-spectrum
#15
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack
Functionally related brain regions are selectively vulnerable to Alzheimer's disease pathophysiology. However, molecular markers of this pathophysiology (i.e., beta-amyloid and tau aggregates) have discrepant spatial and temporal patterns of progression within these selectively vulnerable brain regions. Existing reductionist pathophysiologic models cannot account for these large-scale spatiotemporal inconsistencies. Within the framework of the recently proposed cascading network failure model of Alzheimer's disease, however, these large-scale patterns are to be expected...
December 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29101940/rem-sleep-behavior-disorder-diagnosis-clinical-implications-and-future-directions
#16
REVIEW
Erik K St Louis, Bradley F Boeve
Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especially synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. A history of RBD may begin several years to decades before onset of any clear daytime symptoms of motor, cognitive, or autonomic impairments, suggesting that RBD is the presenting manifestation of a neurodegenerative process...
November 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29044639/inflammatory-pathology-markers-activated-microglia-and-reactive-astrocytes-in-early-and-late-onset-alzheimer-disease-a-post-mortem-study
#17
R Taipa, V Ferreira, P Brochado, A Robinson, I Reis, F Marques, D M Mann, M Melo-Pires, N Sousa
AIMS: The association between the pathological features of AD and dementia is stronger in younger old persons than in older old persons suggesting that additional factors are involved in the clinical expression of dementia in the oldest old. Cumulative data suggests that neuroinflammation plays a prominent role in Alzheimer's disease (AD) and different studies reported an age-associated dysregulation of the neuroimmune system. Consequently, we sought to characterize the pattern of microglial cell activation and astrogliosis in brain post mortem tissue of pathologically confirmed cases of early and late onset AD (EOAD and LOAD) and determine their relation to age...
October 17, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29020327/cognitive-changes-in-prevalent-and-incident-cardiovascular-disease-a-12-year-follow-up-in-the-maastricht-aging-study-maas
#18
Syenna H J Schievink, Martin P J van Boxtel, Kay Deckers, Robert J van Oostenbrugge, Frans R J Verhey, Sebastian Köhler
Aims: Cardiovascular disease (CVD) has been suggested to accelerate cognitive decline and to be a risk factor for dementia, but still little is known about the cognitive course after a first cardiovascular event. Therefore, the present study aims to investigate the cognitive trajectories in both prevalent and incident CVD over a 12-year time period in the general population. Methods and results: Cognitively healthy participants (age 24-82 years, n = 1823) of a prospective cohort study were serially assessed at baseline, 6 and 12 years...
July 22, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018162/clinical-utility-of-amyloid-pet-imaging-with-18-f-florbetapir-a-retrospective-study-of-100-patients
#19
Christopher James Carswell, Zarni Win, Kirsty Muckle, Angus Kennedy, Adam Waldman, Gemma Dawe, Tara D Barwick, Sameer Khan, Paresh A Malhotra, Richard J Perry
BACKGROUND AND OBJECTIVE: Amyloid-positron emission tomography (PET) imaging (API) detects amyloid-beta pathology early in the course of Alzheimer's disease (AD) with high sensitivity and specificity. (18)F-florbetapir (Amyvid) is an amyloid-binding PET ligand with a half-life suitable for clinical use outside of the research setting. How API affects patient investigation and management in the 'real-world' arena is unknown. To address this, we retrospectively documented the effect of API in patients in the memory clinic...
October 10, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28986410/thrombolysis-in-acute-ischemic-stroke-in-patients-with-dementia-a-swedish-registry-study
#20
Eva Zupanic, Mia von Euler, Ingemar Kåreholt, Beatriz Contreras Escamez, Johan Fastbom, Bo Norrving, Dorota Religa, Milica G Kramberger, Bengt Winblad, Kristina Johnell, Maria Eriksdotter, Sara Garcia-Ptacek
OBJECTIVE: To compare access to intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) and its outcomes in patients with and without dementia. METHODS: This was a longitudinal cohort study of the Swedish dementia and stroke registries. Patients with preexisting dementia who had AIS from 2010 to 2014 (n = 1,356) were compared with matched patients without dementia (n = 6,755). We examined access to thrombolysis and its outcomes at 3 months (death, residency, and modified Rankin Scale [mRS] score)...
October 31, 2017: Neurology
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