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https://www.readbyqxmd.com/read/29898972/diffuse-lewy-body-disease-manifesting-as-corticobasal-syndrome-a-rare-form-of-lewy-body-disease
#1
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
June 13, 2018: Neurology
https://www.readbyqxmd.com/read/29889941/association-of-amyloid-positron-emission-tomography-with-changes-in-diagnosis-and-patient-treatment-in-an-unselected-memory-clinic-cohort-the-abide-project
#2
Arno de Wilde, Wiesje M van der Flier, Wiesje Pelkmans, Femke Bouwman, Jurre Verwer, Colin Groot, Marieke M van Buchem, Marissa Zwan, Rik Ossenkoppele, Maqsood Yaqub, Marleen Kunneman, Ellen M A Smets, Frederik Barkhof, Adriaan A Lammertsma, Andrew Stephens, Erik van Lier, Geert Jan Biessels, Bart N van Berckel, Philip Scheltens
Importance: Previous studies have evaluated the diagnostic effect of amyloid positron emission tomography (PET) in selected research cohorts. However, these research populations do not reflect daily practice, thus hampering clinical implementation of amyloid imaging. Objective: To evaluate the association of amyloid PET with changes in diagnosis, diagnostic confidence, treatment, and patients' experiences in an unselected memory clinic cohort. Design, Setting, and Participants: Amyloid PET using fluoride-18 florbetaben was offered to 866 patients who visited the tertiary memory clinic at the VU University Medical Center between January 2015 and December 2016 as part of their routine diagnostic dementia workup...
June 11, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29805385/driving-cessation-in-patients-attending-a-young-onset-dementia-clinic-a-retrospective-cohort-study
#3
Latha Velayudhan, Sarah Baillon, Gabriela Urbaskova, Laura McCulloch, Samuel Tromans, Mathew Storey, James Lindesay, Sagnik Bhattacharyya
Background: Although driving by persons with dementia is an important public health concern, little is known about driving cessation in younger people with dementia. We aimed to determine the prevalence and factors affecting driving cessation in individuals with and without dementia aged under 65 years attending a memory clinic in a European setting. Methods: Subjects were consecutive patients assessed at a specialist memory service at a university teaching hospital between 2000 and 2010...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29755396/overlapping-autoimmune-syndromes-in-patients-with-glial-fibrillary-acidic-protein-antibodies
#4
Xinguang Yang, Huiming Xu, Meilin Ding, Qingmei Huang, Baikeng Chen, Huacai Yang, Tianni Liu, Youming Long, Cong Gao
Background: Glial fibrillary acidic protein (GFAP) astrocytopathy, an autoimmune central nervous system disorder with a specific GFAP-IgG, often coexists with other antibodies. Objective: The aim of this article was to study overlapping syndromes in autoimmune GFAP astrocytopathy. Methods: Antibody was detected by indirect immunofluorescence assay. Patient data were analyzed retrospectively. Results: Thirty patients with positive GFAP-IgG were included, of whom 10 were defined as overlapping syndrome...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29734098/investigation-of-possible-risk-factors-for-depression-in-alzheimer-s-disease-a-systematic-review-of-the-evidence
#5
REVIEW
Natassa Steck, Claudia Cooper, Vasiliki Orgeta
BACKGROUND: Depression is common in people with Alzheimer's disease (AD), and is associated with increased risk of institutionalization and mortality. Understanding risk factors for depression in AD is key to its development and treatment. METHODS: We searched the MEDLINE, EMBASE, PsycINFO, and CINAL databases for longitudinal prospective cohort studies that evaluated risk factors for depression in people with AD. Two authors independently selected articles for inclusion and assessed quality of studies using predetermined criteria...
August 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29730995/16-year-survival-of-the-canadian-collaborative-cohort-of-related-dementias
#6
Maya L Lichtenstein, Nader Fallah, Benita Mudge, Ging-Yuek R Hsiung, Dean Foti, B Lynn Beattie, Howard H Feldman
Background Survival estimates are integral to care for patients diagnosed with dementia. Few Canadian studies have carried out long-term follow-up of well-described cohorts, analyzing survival related to multiple risk factors. Methods Survival analysis of an inception cohort enrolled at a British Columbia (BC) tertiary dementia referral clinic between 1997 and 1999 was undertaken. Vital status was completed for 168 patients diagnosed with dementia. An evaluation of the effects of demographics, vascular risk factors, cognitive and functional ratings, apolipoprotein 4-status, and cholinesterase use on survival was performed using a log-rank test and time-dependent Cox regression...
May 7, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29710395/age-of-first-exposure-to-tackle-football-and-chronic-traumatic-encephalopathy
#7
Michael L Alosco, Jesse Mez, Yorghos Tripodis, Patrick T Kiernan, Bobak Abdolmohammadi, Lauren Murphy, Neil W Kowall, Thor D Stein, Bertrand Russell Huber, Lee E Goldstein, Robert C Cantu, Douglas I Katz, Christine E Chaisson, Brett Martin, Todd M Solomon, Michael D McClean, Daniel H Daneshvar, Christopher J Nowinski, Robert A Stern, Ann C McKee
OBJECTIVE: To examine the effect of age of first exposure to tackle football on CTE pathological severity and age of neurobehavioral symptom onset in tackle football players with neuropathologically-confirmed CTE. METHODS: The sample included 246 tackle football players who donated their brains for neuropathological examination. 211 were diagnosed with CTE (126/211 were without comorbid neurodegenerative diseases) and 35 were without CTE. Informant interviews ascertained age of first exposure and age of cognitive and behavioral/mood symptom onset...
April 30, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29584904/combined-pathologies-in-ftld-tdp-types-a-and-c
#8
Tamar Gefen, Saman S Ahmadian, Qinwen Mao, Garam Kim, Mustafa Seckin, Borna Bonakdarpour, Eliana Marisa Ramos, Giovanni Coppola, Rosa Rademakers, Emily Rogalski, Alfred Rademaker, Sandra Weintraub, M-Marsel Mesulam, Changiz Geula, Eileen H Bigio
This study investigated the presence of combined pathologies in a large cohort of autopsies that show a primary pathologic diagnosis of phosphorylated 43-kDa TAR DNA-binding protein (FTLD-TDP), the majority of which portrayed clinical phenotypes consistent with primary progressive aphasia or behavioral variant frontotemporal dementia (bvFTD). Thirty-eight cases with FTLD-TDP (30 type-A and 8 type-C) were identified to determine characteristic differences between cases with and without combined pathologies. Findings indicated that combined pathologies co-occur with FTLD-TDP type-A at a high frequency (50%)-greater than when compared to FTLD-TDP type-C cases (12...
May 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29519965/-social-systems-and-resources-for-people-with-dementia
#9
Yukihiko Washimi
In the Clinical Guidelines for Dementia 2017, the strategies to support persons with dementia and their families have increased significantly. This article provides a comprehensive and concise explanation of the importance of the newly launched systems and social resources. A new Five-Year Plan for promotion of Dementia Measures ("New Orange Plan") supports the realization of a society where persons with dementia are able to live with dignity as long as possible. New Medical Centers for Dementia provide specialized medical services and integrate community resources for building a comprehensive support network for persons with dementia...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29487403/use-of-an-alzheimer-s-disease-polygenic-risk-score-to-identify-mild-cognitive-impairment-in-adults-in-their-50s
#10
Mark W Logue, Matthew S Panizzon, Jeremy A Elman, Nathan A Gillespie, Sean N Hatton, Daniel E Gustavson, Ole A Andreassen, Anders M Dale, Carol E Franz, Michael J Lyons, Michael C Neale, Chandra A Reynolds, Xin Tu, William S Kremen
Early identification of younger, non-demented adults at elevated risk for Alzheimer's disease (AD) is crucial because the pathological process begins decades before dementia onset. Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who were only in their 50s. Participants were 1176 white, non-Hispanic community-dwelling men of European ancestry in the Vietnam Era Twin Study of Aging (VETSA): 7% with amnestic MCI (aMCI); 4% with non-amnestic MCI (naMCI)...
February 27, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29482653/physical-activity-for-people-with-young-onset-dementia-and-carers-protocol-for-a-scoping-review
#11
Chloe Rodgers, David Rogerson, Judy Stevenson, Davina Porock
BACKGROUND: Physical activity has been cited as a potential symptomatic treatment option for people living with dementia. At present, much of the research concerning physical activity and dementia considers older adults, and there are several review articles summarising the evidence in this area. Less is known about physical activity for younger people with dementia, despite the marked differences in needs and preferences between the two groups. The aim of this scoping review is to systematically explore and critically appraise the current state of the evidence regarding physical activity for people with young-onset dementia and carers...
February 27, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29466804/phenotypic-variability-in-autosomal-dominant-familial-alzheimer-disease-due-to-the-s170f-mutation-of-presenilin-1
#12
Hannes O Tiedt, Beate Benjamin, Michael Niedeggen, Andreas Lueschow
BACKGROUND: In rare cases, patients with Alzheimer disease (AD) present at an early age and with a family history suggestive of an autosomal dominant mode of inheritance. Mutations of the presenilin-1 (PSEN1) gene are the most common causes of dementia in these patients. Early-onset and particularly familial AD patients frequently present with variable non-amnestic cognitive symptoms such as visual, language or behavioural changes as well as non-cognitive, e.g. motor, symptoms. OBJECTIVE: To investigate the phenotypic variability in carriers of the PSEN1 S170F mutation...
February 22, 2018: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/29435558/association-between-amyloid-and-tau-accumulation-in-young-adults-with-autosomal-dominant-alzheimer-disease
#13
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnson
Importance: It is critically important to improve our ability to diagnose and track Alzheimer disease (AD) as early as possible. Individuals with autosomal dominant forms of AD can provide clues as to which and when biological changes are reliably present prior to the onset of clinical symptoms. Objective: To characterize the associations between amyloid and tau deposits in the brains of cognitively unimpaired and impaired carriers of presenilin 1 (PSEN1) E280A mutation...
February 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29378790/features-of-gba-associated-parkinson-s-disease-at-presentation-in-the-uk-tracking-parkinson-s-study
#14
Naveed Malek, Rimona S Weil, Catherine Bresner, Michael A Lawton, Katherine A Grosset, Manuela Tan, Nin Bajaj, Roger A Barker, David J Burn, Thomas Foltynie, John Hardy, Nicholas W Wood, Yoav Ben-Shlomo, Nigel W Williams, Donald G Grosset, Huw R Morris
OBJECTIVES: To examine the influence of the glucocerebrosidase ( GBA ) mutation carrier state on age at onset of Parkinson's disease (PD), the motor phenotype and cognitive function at baseline assessment in a large cohort of UK patients. We also analysed the prevalence of mood and behavioural problems that may confound the assessment of cognitive function. METHODS: We prospectively recruited patients with PD in the Tracking Parkinson's study. We fully sequenced the GBA gene in all recently diagnosed patients (≤3...
January 29, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29346380/rapidly-progressive-dementia-an-eight-year-2008-2016-retrospective-study
#15
Patil Anuja, Vishnu Venugopalan, Naheed Darakhshan, Pandit Awadh, Vinny Wilson, Goyal Manoj, Modi Manish, Lal Vivek
BACKGROUND AND PURPOSE: Rapidly progressive dementia (RPD) is an emergency in cognitive neurology, defined as cognitive impairment affecting the daily living activities developed over less than 1 year. This study investigated the profile of patients with rapidly progressive dementia at first presentation. METHODS: Retrospective case analysis was done in 187 patients with rapidly progressive dementia who presented to the Postgraduate Institute of Medical Education and Research, Chandigarh, India from January 2008 to August 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29336840/heterozygous-tyrobp-deletion-plosl-fin-is-not-a-strong-risk-factor-for-cognitive-impairment
#16
Karri Kaivola, Lilja Jansson, Elmo Saarentaus, Anna Kiviharju, Ville Rantalainen, Johan G Eriksson, Timo E Strandberg, Tuomo Polvikoski, Liisa Myllykangas, Pentti J Tienari
Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's disease when heterozygous. Here, we studied the PLOSLFIN TYROBP deletion that covers 4 of the gene's 5 exons. We genotyped 3220 older Finns (mean age 79, range 58-104) and found 11 deletion carriers (mean age 78, range 60-94)...
April 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29284406/an-additive-effect-of-leading-role-in-the-organization-between-social-participation-and-dementia-onset-among-japanese-older-adults-the-ages-cohort-study
#17
Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao, Katsunori Kondo
BACKGROUND: Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis remains largely unknown. The purpose of the present study was to examine the additive effect of a leadership position in the organization on dementia onset and social participation among elderly people in a local community, according to data from a Japanese older adults cohort study...
December 29, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29228201/widespread-brain-tau-and-its-association-with-ageing-braak-stage-and-alzheimer-s-dementia
#18
Val J Lowe, Heather J Wiste, Matthew L Senjem, Stephen D Weigand, Terry M Therneau, Bradley F Boeve, Keith A Josephs, Ping Fang, Mukesh K Pandey, Melissa E Murray, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Jonathan Graff-Radford, Christopher G Schwarz, Mary M Machulda, Michelle M Mielke, Rosebud O Roberts, David S Knopman, Ronald C Petersen, Clifford R Jack
See Herholz (doi:10.1093/brain/awx340) for a scientific commentary on this article.Autopsy data have proposed that a topographical pattern of tauopathy occurs in the brain with the development of dementia due to Alzheimer's disease. We evaluated the findings of tau-PET to better understand neurofibrillary tangle development as it is seen in cognitively unimpaired and impaired individuals. The evolution of Alzheimer's disease tauopathy in cognitively unimpaired individuals needs to be examined to better understand disease pathogenesis...
January 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29185371/recent-advances-in-longitudinal-structural-neuroimaging-of-younger-onset-dementias
#19
Ramon Landin-Romero, Olivier Piguet
No abstract text is available yet for this article.
December 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29159043/neuroimaging-and-other-modalities-to-assess-alzheimer-s-disease-in-down-syndrome
#20
REVIEW
Natalie Neale, Concepcion Padilla, Luciana Mascarenhas Fonseca, Tony Holland, Shahid Zaman
People with Down syndrome (DS) develop Alzheimer's disease (AD) at higher rates and a younger age of onset compared to the general population. As the average lifespan of people with DS is increasing, AD is becoming an important health concern in this group. Neuroimaging is becoming an increasingly useful tool in understanding the pathogenesis of dementia development in relation to clinical symptoms. Furthermore, neuroimaging has the potential to play a role in AD diagnosis and monitoring of therapeutics. This review describes major recent findings from in vivo neuroimaging studies analysing DS and AD via ligand-based positron emission tomography (PET), [18F] fluorodeoxyglucose (FDG)-PET, structural magnetic resonance imaging (sMRI), and diffusion tensor imaging (DTI)...
2018: NeuroImage: Clinical
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