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https://www.readbyqxmd.com/read/27894966/quantitative-proteomic-changes-during-post-myocardial-infarction-remodeling-reveals-altered-cardiac-metabolism-and-desmin-aggregation-in-the-infarct-region
#1
Kaberi Datta, Trayambak Basak, Swati Varshney, Shantanu Sengupta, Sagartirtha Sarkar
: Myocardial infarction is one of the leading causes of cardiac dysfunction, failure and sudden death. Post infarction cardiac remodeling presents a poor prognosis, with 30%-45% of patients developing heart failure, in a period of 5-25years. Oxidative stress has been labelled as the primary causative factor for cardiac damage during infarction, however, the impact it may have during the process of post infarction remodeling has not been well probed. In this study, we have implemented iTRAQ proteomics to catalogue proteins and functional processes, participating both temporally (early and late phases) and spatially (infarct and remote zones), during post myocardial infarction remodeling of the heart as functions of the differential oxidative stress manifest during the remodeling process...
November 25, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27799523/telomere-shortening-and-metabolic-compromise-underlie-dystrophic-cardiomyopathy
#2
Alex Chia Yu Chang, Sang-Ging Ong, Edward L LaGory, Peggy E Kraft, Amato J Giaccia, Joseph C Wu, Helen M Blau
Duchenne muscular dystrophy (DMD) is an incurable X-linked genetic disease that is caused by a mutation in the dystrophin gene and affects one in every 3,600 boys. We previously showed that long telomeres protect mice from the lethal cardiac disease seen in humans with the same genetic defect, dystrophin deficiency. By generating the mdx(4cv)/mTR(G2) mouse model with "humanized" telomere lengths, the devastating dilated cardiomyopathy phenotype seen in patients with DMD was recapitulated. Here, we analyze the degenerative sequelae that culminate in heart failure and death in this mouse model...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27793430/the-heart-of-africa-succeeding-against-the-odds
#3
Karen Sliwa
South Africa and other areas of sub-Saharan Africa have in the past 20 years undergone rapid demographical changes, largely due to urbanisation and changes in lifestyle. This rapid change has led to a marked increase in specific cardiac conditions, such as hypertensive heart disease and coronary artery disease (with the highest prevalence in the middle-aged population), in conjunction with a range of other heart diseases, which are historically common in Africa-eg, rheumatic heart disease, cardiomyopathies, and unoperated congenital heart disease...
October 24, 2016: Lancet
https://www.readbyqxmd.com/read/27788598/propeptide-big-endothelin-n-terminal-pro-brain-natriuretic-peptide-and-mortality-the-ludwigshafen-risk-and-cardiovascular-health-luric-study
#4
Ingrid Gergei, Bernhard K Krämer, Scharnagl Hubert, Tatjana Stojakovic, März Winfried, Ulrich Mondorf
CONTEXT: The endothelin system (Big-ET-1) is a key regulator in cardiovascular (CV) disease and congestive heart failure (CHF). OBJECTIVES: We have examined the incremental value of Big-ET-1in predicting total and CV mortality next to the well-established CV risk marker N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP). METHODS: Big-ET-1 and NT-proBNP were determined in 2829 participants referred for coronary angiography (follow-up 9.9 years)...
October 28, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27711045/non-invasive-inhaled-nitric-oxide-in-the-treatment-of-hypoxemic-respiratory-failure-in-term-and-preterm-infants
#5
R Sahni, X Ameer, K Ohira-Kist, J-T Wung
OBJECTIVES: Inhaled nitric oxide (iNO) is effective in conjunction with tracheal intubation (TI) and mechanical ventilation (MV) for treating arterial pulmonary hypertension and hypoxemic respiratory failure (HRF) in near-term and term newborns. Non-invasive respiratory support with nasal continuous positive airway pressure (CPAP) is increasingly used to avoid morbidity associated with TI and MV, yet the effectiveness of iNO delivery via nasal CPAP remains unknown. To evaluate the effectiveness of iNO delivered via the bubble nasal CPAP system in term and preterm newborns with HRF...
October 6, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27650163/determining-the-cost-of-implementing-and-operating-a-remote-patient-monitoring-programme-for-the-elderly-with-chronic-conditions-a-systematic-review-of-economic-evaluations
#6
Daniel Peretz, Antonia Arnaert, Norma Ponzoni
INTRODUCTION: Remote patient monitoring (RPM) in conjunction with home nursing visits is becoming increasingly popular for the follow-up of patients with chronic conditions and evidence exists that it improves patients' health outcomes. Current cost data is reported inconsistently and often gathered from studies of poor methodological quality, making it difficult for decision-makers who consider implementing this service in their organizations. This study reviewed the cost of RPM programmes targeting elderly patients with chronic conditions...
September 19, 2016: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/27605451/sfrp2-activates-wnt-%C3%AE-catenin-signaling-in-cardiac-fibroblasts-differential-roles-in-cell-growth-energy-metabolism-and-extracellular-matrix-remodeling
#7
Huey Lin, Mia Angeli, Kwang Jin Chung, Chukwuemeka Ejimadu, Angelica Rivera Rosa, Techung Lee
Secreted Frizzled-related protein 2 (sFRP2) plays a key role in chronic fibrosis after myocardial infarction and in heart failure. The aim of this study was to elucidate the mechanisms through which sFRP2 may regulate the growth and extracellular matrix (ECM) remodeling of adult mouse cardiac fibroblasts (CFs). We found that sFRP2 activates CFs in part through canonical Wnt/β-catenin signaling, as evidenced by increased expression of Axin2 and Wnt3a, but not Wnt5a, as well as accumulation of nuclear β-catenin...
November 1, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27538864/antemortem-screening-for-left-ventricular-hypertrophy-in-rhesus-macaques-macaca-mulatta
#8
Andrew J Haertel, Joshua A Stern, J Rachel Reader, Abigail Spinner, Jeffrey A Roberts, Kari L Christe
Concentric left ventricular hypertrophy (LVH) is a hallmark finding in hypertrophic cardiomyopathy that leads to diastolic dysfunction and variable cardiac consequences as severe as congestive heart failure and sudden cardiac death. LVH was diagnosed postmortem in a large colony of rhesus macaques (Macaca mulatta), but methods to screen and diagnose LVH in living animals are desired. We hypothesized that targeted echocardiography of macaques with a familial association of LVH would yield antemortem LVH diagnoses...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27516911/amphetamine-containing-dietary-supplements-and-acute-myocardial-infarction
#9
Julio Perez-Downes, Abdulwahab Hritani, Candice Baldeo, Patrick Antoun
Weight loss is one of the most researched and marketed topics in American society. Dietary regimens, medications that claim to boost the metabolism, and the constant pressure to fit into society all play a role in our patient's choices regarding new dietary products. One of the products that are well known to suppress appetite and cause weight loss is amphetamines. While these medications suppress appetite, most people are not aware of the detrimental side effects of amphetamines, including hypertension, tachycardia, arrhythmias, and in certain instances acute myocardial infarction...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27484195/muscleblind-like-3-deficit-results-in-a-spectrum-of-age-associated-pathologies-observed-in-myotonic-dystrophy
#10
Jongkyu Choi, Donald M Dixon, Warunee Dansithong, Walid F Abdallah, Kenneth P Roos, Maria C Jordan, Brandon Trac, Han Shin Lee, Lucio Comai, Sita Reddy
Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies. In DM1, dominant effects of expanded CUG repeats result in part from the inactivation of the muscleblind-like (MBNL) proteins. To test the role of MBNL3, we deleted Mbnl3 exon 2 (Mbnl3(ΔE2)) in mice and examined the onset of age-associated diseases over 4 to 13 months of age. Accelerated onset of glucose intolerance with elevated insulin levels, cardiac systole deficits, left ventricle hypertrophy, a predictor of a later onset of heart failure and the development of subcapsular and cortical cataracts is observed in Mbnl3(ΔE2) mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27432266/proteomic-profiling-of-cardiomyocyte-specific-cathepsin-a-overexpression-links-cathepsin-a-to-the-oxidative-stress-response
#11
Agnese Petrera, Ursula Kern, Dominik Linz, Alejandro Gomez-Auli, Mathias Hohl, Johann Gassenhuber, Thorsten Sadowski, Oliver Schilling
Cathepsin A (CTSA) is a lysosomal carboxypeptidase present at the cell surface and secreted outside the cell. Additionally, CTSA binds to β-galactosidase and neuraminidase 1 to protect them from degradation. CTSA has gained attention as a drug target for the treatment of cardiac hypertrophy and heart failure. Here, we investigated the impact of CTSA on the murine cardiac proteome in a mouse model of cardiomyocyte-specific human CTSA overexpression using liquid chromatography-tandem mass spectrometry in conjunction with an isotopic dimethyl labeling strategy...
September 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27403182/tolvaptan-a-novel-diuretic-in-heart-failure-management
#12
REVIEW
Hilman Zulkifli Amin, Siska Suridanda Danny
Heart failure (HF) is still a major problem worldwide with high morbidity and mortality rates. The recently developed medication for HF is still incapable of reducing its morbidity and mortality, and clinical data supporting the efficacy and safety of its mainstay therapy remain insufficient. Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor. In patients with HF, there is an increased level of AVP, contributing to such symptoms as edema, dyspnea, and congestion...
January 13, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/27380949/underuse-of-%C3%AE-blockers-in-heart-failure-and-chronic-obstructive-pulmonary-disease
#13
Brian Lipworth, Derek Skinner, Graham Devereux, Victoria Thomas, Joanna Ling Zhi Jie, Jessica Martin, Victoria Carter, David B Price
OBJECTIVE: Although β-blockers are an established therapy in heart failure (HF) guidelines, including for patients with chronic obstructive pulmonary disease (COPD), there remain concerns regarding bronchoconstriction even with cardioselective β-blockers. We wished to assess the real-life use of β-blockers for patients with HF and comorbid COPD. METHODS: We evaluated data from the Optimum Patient Care Research Database over a period of 1 year for co-prescribing of β-blockers with either an ACE inhibitor (ACEI) or angiotensin-2 receptor blocker (ARB) in patients with HF alone versus HF+COPD...
December 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27220692/diagnostic-performance-and-reference-values-of-novel-biomarkers-of-paediatric-heart-failure
#14
Jakob A Hauser, Svitlana Demyanets, Krisztina Rusai, Clara Goritschan, Michael Weber, Dilveer Panesar, Lisa Rindler, Andrew M Taylor, Rodrig Marculescu, Michael Burch, Johann Wojta, Ina Michel-Behnke
OBJECTIVE: Biomarkers play a pivotal role in heart failure (HF) management. Reference values and insights from studies in adults cannot be extrapolated to the paediatric population due to important differences in pathophysiology and compensatory reserve. We assessed the diagnostic utility of four novel biomarkers in paediatric HF. METHODS: Midregional (MR) pro-atrial natriuretic peptide (proANP), soluble ST2 (sST2), growth differentiation factor-15 (GDF-15), MR-pro-adrenomedullin (proADM) and N-terminal pro-B natriuretic peptide (NT-proBNP) were measured in 114 patients and 89 controls...
October 15, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27145910/insights-into-the-importance-of-the-electrocardiogram-in-patients-with-acute-heart-failure
#15
Pishoy Gouda, Paul Brown, Brian H Rowe, Finlay A McAlister, Justin A Ezekowitz
BACKGROUND: Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and/or complications. It is unclear whether 12-lead ECG characteristics can serve as a prognostic indicator in this population. METHODS AND RESULTS: Patients with AHF from four hospital EDs were prospectively enrolled into the AHF - Emergency Management cohort...
August 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27102504/chronotropic-incompetence-does-not-limit-exercise-capacity-in-chronic-heart-failure
#16
COMPARATIVE STUDY
Haqeel A Jamil, John Gierula, Maria F Paton, Roo Byrom, Judith E Lowry, Richard M Cubbon, David A Cairns, Mark T Kearney, Klaus K Witte
BACKGROUND: Limited heart rate (HR) rise (HRR) during exercise, known as chronotropic incompetence (CI), is commonly observed in chronic heart failure (CHF). HRR is closely related to workload, the limitation of which is characteristic of CHF. Whether CI is a causal factor for exercise intolerance, or simply an associated feature remains unknown. OBJECTIVES: This study sought to clarify the role of the HR on exercise capacity in CHF. METHODS: This series of investigations consisted of a retrospective cohort study and 2 interventional randomized crossover studies to assess: 1) the relationship between HRR and exercise capacity in CHF; and 2) the effect of increasing and lowering HR on exercise capacity in CHF as assessed by symptom-limited treadmill exercise testing and measurement of peak oxygen consumption in patients with CHF due to left ventricular systolic dysfunction...
April 26, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27079896/palliative-care-in-patients-with-heart-failure
#17
REVIEW
Colleen K McIlvennan, Larry A Allen
Despite advances in cardiac therapy, heart failure (HF) remains a progressive, highly symptomatic, and deadly disease that places great demands on patients, caregivers, and healthcare systems. Palliative care is a multidisciplinary approach to care that focuses on communication, shared decision making, and advance care planning; provides relief from pain and other distressing symptoms; integrates psychological and spiritual aspects of care; and offers a support system to help families cope during illness and bereavement...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27023909/mitochondrial-defects-associated-with-%C3%AE-alanine-toxicity-relevance-to-hyper-beta-alaninemia
#18
Aza Shetewy, Kayoko Shimada-Takaura, Danielle Warner, Chian Ju Jong, Abu-Bakr Al Mehdi, Mikhail Alexeyev, Kyoko Takahashi, Stephen W Schaffer
Hyper-beta-alaninemia is a rare metabolic condition that results in elevated plasma and urinary β-alanine levels and is characterized by neurotoxicity, hypotonia, and respiratory distress. It has been proposed that at least some of the symptoms are caused by oxidative stress; however, only limited information is available on the mechanism of reactive oxygen species generation. The present study examines the hypothesis that β-alanine reduces cellular levels of taurine, which are required for normal respiratory chain function; cellular taurine depletion is known to reduce respiratory function and elevate mitochondrial superoxide generation...
May 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26975167/-angiotensin-receptor-and-neprilysin-inhibition-a-new-option-against-heart-failure
#19
REVIEW
Claudia Bruhn
The molecular combination of sacubitril and valsartan (Entresto) is a new drug for reducing the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It is usually administered in conjunction with other heart failure therapies, instead of an ACE inhibitor or an angiotensin-receptor blocker (ARB). In studies, sacubitril/ valsartan was superior to enalapril in reducing the risks of death and hospitalization for heart failure...
January 2016: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/26968107/b-type-natriuretic-peptide-signal-peptide-bnpsp-in-patients-presenting-with-chest-pain
#20
Chris J Pemberton, Chris M Frampton, Sally Aldous, Mark Bailey, Joanna Young, Richard Troughton, Martin Than, Mark Richards
OBJECTIVES: We assessed the ability of B-type natriuretic peptide signal peptide (BNPsp) to assist with the identification of patients with myocardial infarction (MI) and unstable angina pectoris (UAP). DESIGN AND METHODS: We studied 505 patients who presented to hospital within 4h of onset of chest pain suspicious of ACS. Blood samples were drawn at 0, 1, 2 and 24h from presentation and assayed for BNPsp, NT-proBNP, TnI and high sensitivity TnT. The ability of BNPsp and other markers to diagnose acute myocardial infarction (MI) and unstable angina pectoris (UAP) and predict subsequent events within one year was assessed...
June 2016: Clinical Biochemistry
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