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helicobacter pediatrics

Thomas G Blanchard, Steven J Czinn
Establishment of Helicobacter pylori infection as an etiologic agent of peptic ulcer disease and other gastric pathologies marked a revolution in gastroenterology which spurred an enormous interest in gastric physiology and immunology research. The association was soon also demonstrated in children as well. Application of antimicrobial therapies have proven remarkably efficacious in eradicating H. pylori and curing pediatric patients of duodenal ulcers as well as gastritis, negating a lifetime of ineffective therapy and life-threatening disease...
October 4, 2016: Pediatric Research
Amin Talebi Bezmin Abadi, Johannes G Kusters
BACKGROUND: Infection with Helicobacter pylori is associated with severe digestive diseases including chronic gastritis, peptic ulcer disease, and gastric cancer. Successful eradication of this common gastric pathogen in individual patients is known to prevent the occurrence of peptic ulcer disease and gastric cancer. DISCUSSION: With half of the world's population being infected with H, pylori and only few antibiotics result in an effective eradication, a successful antibiotic driven worldwide eradication program seems unlikely...
2016: BMC Gastroenterology
Thomas Regnath, Olaf Raecke, Axel Enninger, Ralf Ignatius
BACKGROUND: Increasing antibiotic resistance has been reported for Helicobacter pylori, but data on the prevalence of antibiotic resistance of H. pylori in pediatric patients and the development of resistance over time are sparse. METHODS: Data for 610 H. pylori isolates obtained between 2002 and 2015 from gastric biopsies of 582 (mainly treatment-naïve) pediatric patients from southwest Germany were analyzed retrospectively regarding the antibiotic susceptibility determined by Etest and patients' characteristics...
July 11, 2016: Helicobacter
Tugba Koca, Filiz Serdaroglu, Selim Dereci, Mustafa Akcam
OBJECTIVE: To study the characteristics of peptic ulcer and erosion in pediatric patients. METHODS: Over a period of seven years, 1,026 children underwent upper gastrointestinal endoscopy in our pediatric gastroenterology unit. RESULTS: Peptic ulcers and erosions were found in 59 (7.2%) patients [ulcers in 42 (5.1%)and erosions in 17 (2.1%)]. Thirty (50.9%) children presented with acute upper gastrointestinal bleeding. Helicobacter pylori positivity was found in 27 patients (45...
August 8, 2016: Indian Pediatrics
J Wasilewska, M Klukowski, K Debkowska, J Kilon, D Citko, M Flisiak, M Oleksinska, M Kaczmarski
OBJECTIVE: Chronic Helicobacter pylori (HP) infection is considered to be a factor involved in obstructive sleep apnea syndrome (OSAS). This cross-sectional study examined the seroprevalence of HP in children with sleep-disordered breathing (SDB) in respect to OSAS severity and in reference to other common pediatric medical conditions. METHODS: Overnight polysomnography with pH-metry (PSG) was performed at a Sleep Laboratory (in the years 2008-2011). OSAS severity was determined based on Obstructive Apnea Index (OAI)...
August 2016: International Journal of Pediatric Otorhinolaryngology
Nuria Boronat-Echeverría, Héctor Aguirre-Mariscal, Margarita Carmolinga-Ponce, Yolanda Sevilla-Delgado, Ricardo Miceli-Flores, Aisha Kennedy-Padilla, Juan Manuel Mejía-Aranguré
OBJECTIVES: The study aimed to demonstrate Helicobacter pylori presence in otitis media with effusion (OME) and its association with symptomatology of gastroesophageal reflux disease (GERD). METHODS: In a cohort study, 69 effusions were collected during tympanostomy tube insertion for H. pylori detection using PCR and ELISA. Validated questionnaires were performed according to age for clinical diagnosis of GERD; chi-square ×2 statistical analysis was made. RESULTS: Eight of the 69 ear effusions (5...
August 2016: International Journal of Pediatric Otorhinolaryngology
D Ortiz-Princz, G Daoud, A Salgado-Sabel, M E Cavazza
The prevalence of H. pylori infection, mainly acquired during childhood and may be persisting throughout life, has been found high in developing countries; this high prevalence is related to low socioeconomic status. The persistence of bacterium exposure is related to gastritis and other severe complications including peptic ulcer, lymphoma MALT and gastric cancer, which are rarely present in the pediatric age due to a lower inflammatory and immunological response. Virulence factors, host gastric mucosal factors, and the natural environment of patients are associated with the clinical outcome of H...
May 2016: European Review for Medical and Pharmacological Sciences
Carolina A Serrano, Miguel A Leon, Camila Palma, Macarena Vera, Caroll Hernandez, Paul R Harris
INTRODUCTION: Failure to eradicate Helicobacter pylori despite antibiotic treatment is generally attributed to increasing clarithromycin resistance conferred by point mutations in the 23S-rRNA gene or metronidazole resistance attributed to rdxA gene deletion in patients. Scarce data for pediatric population are available from developing countries. OBJECTIVES: To determine the presence of A2142G/C and A2143G mutations in the 23S-rRNA gene and/or rdxA gene deletion in a group of symptomatic H...
May 6, 2016: Journal of Pediatric Gastroenterology and Nutrition
Ofelia Castillo Contreras, Jorge Maguiña Quispe, Harold Benites Goñi, Alfonso Chacaltana Mendoza, Edson Guzmán Calderón, Milagros Dávalos Moscol, Oscar Frisancho Velarde
OBJECTIVE: To determine the prevalence of Helicobacter pylori in symptomatic outpatients in Red Rebagliati (EsSalud) from 2010 to 2013. MATERIAL AND METHODS: An observational, transversal and analytical study. Records of outpatients with diagnostic 13C-urea breath test of Helicobacter pylori in the period 2010-2013 were reviewed. RESULTS: Of the 1711 patients, the overall prevalence of Helicobacter pylori was 45.5% (95% CI: 43.17-47.89) being higher in women than in men (47...
January 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Eun Hye Lee, Hye Ran Yang, Hye Seung Lee
BACKGROUND/AIMS: Abdominal pain-related functional gastrointestinal disorder (AP-FGID) is common in children and adults. However, the mechanism of AP-FGID is not clearly known. Recently, micro-inflammation, especially eosinophilia in the gastrointestinal tract, was suggested in the pathophysiology of AP-FGID in adults. The aim of this study was to evaluate the association of gastric and duodenal eosinophilia with pediatric AP-FGID. METHODS: In total, 105 pediatric patients with AP-FGID were recruited and classified into 4 subgroups based on the Rome III criteria...
July 30, 2016: Journal of Neurogastroenterology and Motility
Norishi Ueda
Background.  There is no literature review on gastroduodenal perforation or ulcer (GDPU) with rotavirus (RV) and norovirus (NoV) gastroenteritis. Methods.  Pediatric cases of GDPU or upper gastrointestinal bleeding with RV and NoV gastroenteritis were searched from September 1974 until October 2015 using PubMed, Google for English, other-language-publications, and Ichushi ( for Japanese-language publications. All reports confirming GDPU or upper gastrointestinal bleeding with RV and NoV gastroenteritis were eligible for inclusion in the study...
January 2016: Open Forum Infectious Diseases
Sabrina Cardile, Massimo Martinelli, Arrigo Barabino, Paolo Gandullia, Salvatore Oliva, Giovanni Di Nardo, Luigi Dall'Oglio, Francesca Rea, Gian Luigi De' Angelis, Barbara Bizzarri, Graziella Guariso, Enzo Masci, Annamaria Staiano, Erasmo Miele, Claudio Romano
AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug (NSAIDs) use in children. METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation...
February 7, 2016: World Journal of Gastroenterology: WJG
Jan Józefczuk, Edyta Mądry, Jan Nowak, Marek Walkowiak, Klaudia Łochocka, Tomasz Banasiewicz, Andrzej Pławski, Jarosław Kwiecień, Jarosław Walkowiak
BACKGROUND: There are no data addressing the usefulness of non-invasive tests for the detection of Helicobacter pylori (HP) infection in celiac disease (CD). AIM: The aim of this study was to compare two most sensitive and specific tests - urea breath test (UBT) and fecal antigen test (FAT) in HP diagnosis in CD patients. MATERIALS AND METHODS: The study comprised of 76 CD patients, 49 healthy subjects (HS) and 35 patients who underwent differential diagnosis due to abdominal pain (AP patients)...
2016: Acta Biochimica Polonica
Emin Cakmakci, Gulseren Evirgen Sahin, Ferda Ozbay Hosnut, Hasibe Gokce Cinar, Berna Ucan, Melek Pala, Yasemin Tasci Yildiz
BACKGROUND: To find out if transabdominal ultrasonography (US) may have a predictive role for detection of antral gastritis and Helicobacter pylori (HP) infection in the antrum of pediatric age group. METHODS: A total of 91 (63.6%) patients and 52 (36.4%) controls were allocated into two groups as follows: Group 1 (n=91): patients with complaints and endoscopic findings consistent with gastritis and documented HP infection; Group 2 (n=52): patients with complaints and endoscopic findings consistent with gastritis in the absence of documented HP infection...
December 2015: Quantitative Imaging in Medicine and Surgery
Zerrin Önal, Fügen Çullu-Çokuğraş, Hüseyin Işıldak, Asım Kaytaz, Tufan Kutlu, Tülay Erkan, Gülen Doğusoy
Gastroesophageal reflux is considered a risk factor for recurrent or persistent upper and lower respiratory tract conditions including asthma, chronic cough, sinusitis, laryngitis, serous otitis and paroxysmal laryngospasm. Fifty-one subjects with recurrent (more than three) episodes of upper respiratory tract infection (URTI), serous otitis or sinusitis who had been admitted to an earnose- throat (ENT) outpatient clinic during the previous year were enrolled in the present study to evaluate the presence of laryngeal and/or esophageal reflux...
May 2015: Turkish Journal of Pediatrics
Salih Maçin, Hülya Demir, Hasan Özen, Aysel Yüce, Yakut Akyön
In this study, our aim was to show the antibiotic resistance patterns of Helicobacter pylori (H. pylori) strains isolated from patients who had undergone esophagogastroduodenoscopy at Hacettepe University. Ninety-three culturepositive patients with no history of H. pylori treatment were included in the study. MIC values against clarithromycin, metronidazole, amoxicillin and tetracycline were evaluated by gradient strips. In the 93 strains, no resistance against tetracycline and amoxicillin was observed. Clarithromycin resistance was detected in 28 (30...
May 2015: Turkish Journal of Pediatrics
Ji-Hyun Seo, Ji Sook Park, Kwang Ho Rhee, Hee-Shang Youn
The diagnosis of Helicobacter pylori (H. pylori) infection is usually based on the results of urease test and histology. The urease test known as a simple and cheap method does not need special skills to perform or to read the result. The time needed for the test to turn positive depends on the concentration of bacteria, and the accuracy is up to the density of H. pylori density in the biopsy sample, which is generally lower in children than adolescents and adults. Therefore, there are debates about the sensitivity of the urease test in children...
November 8, 2015: World Journal of Clinical Pediatrics
Qiao Yu, Shenghong Zhang, Li Li, Lishou Xiong, Kang Chao, Bihui Zhong, Yuwen Li, Huiling Wang, Minhu Chen
The Helicobacter species in the gut microbiota comprise Helicobacter pylori (H pylori) and enterohepatic Helicobacter species (EHS), which can colonize the intestinal mucosa. However, it is unclear whether EHS are associated with inflammatory bowel disease (IBD). Therefore, we conducted this meta-analysis to examine the association between EHS and IBD.PubMed, Scopus, Cochrane Library, and Web of Science databases, as well as abstracts from conference proceedings were searched to identify studies that used polymerase chain reaction to detect Helicobacter species in intestinal samples from patients with IBD...
November 2015: Medicine (Baltimore)
G Oderda, M Marietti, R Pellicano
Helicobacter pylori (H. pylori) infection is a large worldwide infection usually acquired during childhood, whose prevalence in pediatric population varies, with lower incidence rates in developed countries compared to developing countries (up to 10-15% and 70%, respectively). Diagnosis can be performed both with endoscopic-based methods and noninvasive diagnostic tests, such as urea breath test and fecal antigen. Current guidelines recommend endoscopic evaluation of the young patients, in order to determine the underlying cause of abdominal pain...
December 2015: Minerva Pediatrica
Ödül Egritaş Gürkan, Aysel Ünlüsoy Aksu, Zeliha Demirtaş, Buket Dalgıç
BACKGROUND/AIMS: Considering the etiology of cyclic vomiting syndrome (CVS) in childhood, a variety of underlying organic causes has been clearly identified in the literature. The aim of this study was to emphasize that endoscopic evaluation in the first step may help diagnosis and treatment in patients with CVS, unlike the CVS-related "North American Society for Pediatric Gastroenterology, Hepatology and Nutrition" (NASPGHAN) consensus statement in 2008. MATERIALS AND METHODS: The medical files of patients with vomiting complaints admitted to our tertiary center between the years 2007 and 2012 were analyzed retrospectively...
November 2015: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
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