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https://www.readbyqxmd.com/read/29415337/host-response-genes-associated-with-nodular-gastritis-in-h-pylori-infection
#1
Tamaki Ikuse, Yoshikazu Ohtsuka, Naho Obayashi, Keisuke Jimbo, Yo Aoyagi, Takahiro Kudo, Daisuke Asaoka, Mariko Hojo, Akihito Nagahara, Sumio Watanabe, Thomas G Blanchard, Steven J Czinn, Toshiaki Shimizu
BACKGROUND: Chronic Helicobacter pylori (H. pylori) infection in children induces lymphoid hyperplasia called nodular gastritis (NG) at the antral gastric mucosa. The aim of this study was to evaluate genes in gastric biopsies by microarray analysis to identify molecules associated with NG when compared to NG-negative pediatric corpus tissue and H. pylori-infected adult tissue with atrophic gastritis (AG). METHODS: Eight pediatric and six adult H. pylori-infected patients, as well as six pediatric and six adult uninfected patients were evaluated...
February 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29379535/diagnostic-yield-of-esophagogastroduodenoscopy-in-children-with-chronic-abdominal-pain
#2
Ulas Emre Akbulut, Hamdi Cihan Emeksiz, Fatma Gulgun Kocak, Ayten Livaoglu
Introduction: Chronic abdominal pain (CAP) is one of the most common indications of esophagogastroduodenoscopy (EGD) in the pediatric population. However, there is not enough information about the diagnostic yield of EGD in children with CAP. We aimed to evaluate the diagnostic yield of EGD in children with CAP in the Eastern Black Sea region of Turkey. Material and methods: The study included children (n = 372) who underwent EGD for the primary indication of chronic abdominal pain during an 18-month period...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29379534/stool-antigen-detection-versus-13c-urea-breath-test-for-non-invasive-diagnosis-of-pediatric-helicobacter-pylori-infection-in-a-limited-resource-setting
#3
Mortada El-Shabrawi, Nabil Abd El-Aziz, Tarek Zakaria El-Adly, Fetouh Hassanin, Ayman Eskander, Maha Abou-Zekri, Hala Mansour, Safa Meshaal
Introduction: The prevalence of childhood infection with Helicobacter pylori is high, especially in developing countries. Non-invasive methods for detection of infection in children should be inexpensive, easy to perform, well tolerated and have a high diagnostic accuracy. We aimed to compare the reliability, specificity and sensitivity of the H. pylori stool antigen (HpSA) test with the 13C-urea breath test (13C-UBT) for the diagnosis of H. pylori infection in a limited resource setting...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29302504/characteristics-of-upper-gastrointestinal-tract-involvement-in-korean-pediatric-crohn-s-disease-a-multicenter-study
#4
Ji Hyoung Park, Hye Na Nam, Ji-Hyuk Lee, Jeana Hong, Dae Yong Yi, Eell Ryoo, In Sang Jeon, Hann Tchah
Purpose: Crohn's disease (CD) can involve any site of the gastrointestinal tract (GIT). However, the characteristics of upper GIT involvement in CD are unclear, especially in the Eastern pediatric population. This study aimed to estimate the prevalence of upper GIT involvement and identify the clinical features of Korean children with CD. Methods: This was a retrospective multicenter cohort study that included 52 pediatric patients with CD who underwent esophagogastroduodenoscopy and biopsy...
December 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29259371/probiotics-for-gastrointestinal-disorders-proposed-recommendations-for-children-of-the-asia-pacific-region
#5
REVIEW
Donald Cameron, Quak Seng Hock, Musal Kadim, Neelam Mohan, Eell Ryoo, Bhupinder Sandhu, Yuichiro Yamashiro, Chen Jie, Hans Hoekstra, Alfredo Guarino
Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects, health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system...
December 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29235736/primary-and-secondary-antibiotic-resistance-of-helicobacter-pylori-in-israeli-children-and-adolescents
#6
Michal Kori, Jacob Yahav, Rita Berdinstein, Haim Shmuely
BACKGROUND: Empiric treatment for Helicobacter pylori is influenced by antibiotic susceptibility of infecting strains. A rise in the resistance rate to clarithromycin and metronidazole has been reported in pediatric populations. OBJECTIVES: To assess the primary and secondary antibiotic resistance of H. pylori isolates in Israeli children and adolescents. METHODS: A retrospective review of H. pylori isolates cultured from antral biopsies of consecutive children aged 1 to 18 years, who were referred to the Pediatric Gastroenterology Unit, Kaplan Medical Center, over a 2...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29221216/probiotics-in-14-day-triple-therapy-for-asian-pediatric-patients-with-helicobacter-pylori-infection-a-network-meta-analysis
#7
Juanjuan Wen, Pailan Peng, Pengfei Chen, Lirong Zeng, Qinghua Pan, Wenbin Wei, Jianhua He
Although 14-day triple therapy has been widely administrated for eradicating Helicobacter pylori (H. pylori) in Asia, its antibiotic-associated side effects restrict the effectivity of eradication therapy in pediatric patients. Therefore, a network meta-analysis (NMA) was conducted to compare the efficacy and safety of probiotics supplemented in 14-day triple therapy in Asian pediatric patients. Materials and Methods: Randomized controlled trials (RCTs) were retrieved comprehensively in electronic databases (such as PubMed, Cochrane library, Embase, CNKI, Wan fang database, VIP database and CBM) until April 2017...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977115/evaluation-of-human-leukocyte-antigen-class-i-and-ii-antigens-in-helicobacter-pylori-positive-pediatric-patients-with-active-gastritis-and-duodenal-ulcer
#8
Sevim Gönen, Sinan Sari, Yaşar Kandur, Buket Dalgiç, Oğuz Söylemezoğlu
BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. OBJECTIVE: The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center...
October 2, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28913339/ulcerative-gastritis-and-esophagitis-in-two-children-with-sarcina-ventriculi-infection
#9
Tim G J de Meij, Michiel P van Wijk, Aart Mookhoek, Andries E Budding
Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28891139/helicobacter-pylori-infection-in-children
#10
REVIEW
Nicolas Kalach, Patrick Bontems, Josette Raymond
Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28888898/duodenal-pathologies-in-children-a-single-center-experience
#11
Ulas Emre Akbulut, Sami Fidan, Hamdi Cihan Emeksiz, Orhan Polat Ors
OBJECTIVE: Several studies have been performed concerning pathologies of the stomach and esophagus in the pediatric age group. However, there have been very few studies of duodenal pathologies in children. The authors aimed to examine the clinical, endoscopic, and histopathological characteristics, as well as the etiology of duodenal pathologies in children. METHOD: Patients aged between 1 and 17 years undergoing esophagogastroduodenoscopy during two years at this unit, were investigated retrospectively...
September 7, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28813514/the-helicobacter-pylori-type-iv-secretion-system-promotes-il-8-synthesis-in-a-model-of-pediatric-airway-epithelium-via-p38-map-kinase
#12
Myra G Dela Pena-Ponce, Monica T Jimenez, Lori M Hansen, Jay V Solnick, Lisa A Miller
Epidemiologic studies have reported an inverse relationship between childhood Helicobacter pylori infection and development of allergic asthma. Because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that H. pylori may directly influence airway epithelial cell innate immune function, particularly in early childhood. To test our hypothesis, we established an in vitro H. pylori infection model using primary tracheobronchial epithelial cell cultures derived from infant, juvenile and adult rhesus monkeys...
2017: PloS One
https://www.readbyqxmd.com/read/28746216/the-impact-of-host-s-genetic-susceptibility-on-helicobacter-pylori-infection-in-children
#13
Maria Oana Mărginean, Cristina Oana Mărginean, Lorena Elena Meliţ, Septimiu Voidăzan, Valeriu Moldovan, Claudia Bănescu
The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. Children were assessed clinically, endoscopically, histopathologically, and genetically...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681188/helicobacter-pylori-infection-serum-pepsinogens-and-pediatric-abdominal-pain-a-pilot-study
#14
Eias Kassem, Medhat Naamna, Kadri Mawassy, Gany Beer-Davidson, Khitam Muhsen
The significance of Helicobacter pylori (H. pylori) infection in pediatric abdominal pain remains poorly recognized. We examined associations of H. pylori infection and serum pepsinogens (PGs), as non-invasive markers of gastritis, with pediatric abdominal pain. A case-control study was conducted among 99 children aged 5-17 years admitted to one hospital for abdominal pain (cases) without an apparent organic reason. Using enzyme-linked immunosorbent assays, sera were tested and compared with 179 controls for anti-H...
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28681177/efficacy-and-safety-of-probiotic-supplemented-triple-therapy-for-eradication-of-helicobacter-pylori-in-children-a-systematic-review-and-network-meta-analysis
#15
REVIEW
Jue-Rong Feng, Fan Wang, Xiao Qiu, Lynne V McFarland, Peng-Fei Chen, Rui Zhou, Jing Liu, Qiu Zhao, Jin Li
AIM: The aim of this study was to identify the best probiotic supplementation in triple therapy for pediatric population with Helicobacter pylori infection. METHODS: Eligible trials were identified by comprehensive searches. Relative risks with 95% confidence intervals and relative ranks with P scores were assessed. RESULTS: Twenty-nine trials (3122 participants) involving 17 probiotic regimens were identified. Compared with placebo, probiotic-supplemented triple therapy significantly increased H...
October 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28541262/joint-espghan-naspghan-guidelines-for-the-management-of-helicobacter-pylori-in-children-and-adolescents-update-2016
#16
Nicola L Jones, Sibylle Koletzko, Karen Goodman, Patrick Bontems, Samy Cadranel, Thomas Casswall, Steve Czinn, Benjamin D Gold, Jeannette Guarner, Yoram Elitsur, Matjaž Homan, Nicolas Kalach, Michal Kori, Armando Madrazo, Francis Megraud, Alexandra Papadopoulou, Marion Rowland
BACKGROUND: Because of the changing epidemiology of Helicobacter pylori infection and low efficacy of currently recommended therapies, an update of the European Society for Paediatric Gastroenterology Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition recommendations for the diagnosis and management of H pylori infection in children and adolescents is required. METHODS: A systematic review of the literature (time period: 2009-2014) was performed...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28495503/sex-differences-in-the-prevalence-of-helicobacter-pylori-infection-in-pediatric-and-adult-populations-systematic-review-and-meta-analysis-of-244-studies
#17
REVIEW
Abdulrazak Ibrahim, Samantha Morais, Ana Ferro, Nuno Lunet, Bárbara Peleteiro
BACKGROUND: The main outcome of Helicobacter pylori infection, i.e. gastric cancer, is more frequent in men, but there is no comprehensive synthesis of the evidence on a potential role of sex in the acquisition and/or persistence of infection. AIMS: To quantify the association between sex and H. pylori infection in pediatric and adult populations, through systematic review and meta-analysis. METHODS: PubMed® was searched, from inception to September 2015, to identify population-based studies reporting the prevalence and/or incidence of H...
July 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28474959/is-a-multidisciplinary-aerodigestive-clinic-more-effective-at-treating-recalcitrant-aerodigestive-complaints-than-a-single-specialist
#18
Janine M Rotsides, Gina M Krakovsky, Dinesh K Pillai, Sona Sehgal, Maura E Collins, Carolyn E Noelke, Nancy M Bauman
OBJECTIVE: To determine the utility of a pediatric multidisciplinary aerodigestive clinic (ADC) in treating recalcitrant aerodigestive conditions. METHODS: Longitudinal observational study of presenting complaints, evaluation, management, and outcome of patients seen during 12 monthly ADCs beginning August 2013. RESULTS: Fifty-five patients were seen by the ADC team (otolaryngology/gastroenterology/pulmonology/speech pathology/nurse practitioner) and followed for a mean 17...
July 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28459602/inverse-correlation-between-helicobacter-pylori-colonization-and-pediatric-overweight-a-preliminary-study
#19
Hadar Moran-Lev, Ronit Lubetzky, Dror Mandel, Anat Yerushalmy-Feler, Shlomi Cohen
BACKGROUND: Helicobacter pylori, one of the most common bacterial pathogens in humans, is generally acquired during childhood. The inverse correlation between H. pylori colonization and obesity that was found in adults has not been investigated in depth in children. Our aim was to assess the correlation between overweight and obesity and H. pylori colonization in a pediatric population. METHODS: H. pylori colonization in 70 symptomatic children was determined after antral biopsies during esophagogastroduodenoscopy...
August 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28436598/the-expression-of-helicobacter-pylori-tfs-plasticity-zone-cluster-is-regulated-by-ph-and-adherence-and-its-composition-is-associated-with-differential-gastric-il-8-secretion
#20
Bruno Silva, Alexandra Nunes, Filipa F Vale, Raquel Rocha, João Paulo Gomes, Ricardo Dias, Mónica Oleastro
BACKGROUND: Helicobacter pylori virulence is associated with different clinical outcomes. The existence of an intact dupA gene from tfs4b cluster has been suggested as a predictor for duodenal ulcer development. However, the role of tfs plasticity zone clusters in the development of ulcers remains unclear. We studied several H. pylori strains to characterize the gene arrangement of tfs3 and tfs4 clusters and their impact in the inflammatory response by infected gastric cells. METHODS: The genome of 14 H...
April 24, 2017: Helicobacter
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