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https://www.readbyqxmd.com/read/29214141/new-trends-in-anaphylaxis
#1
REVIEW
Margitta Worm, Gunter Sturm, Jörg Kleine-Tebbe, Ewa Cichocka-Jarosz, Victoria Cardona, Ioana Maris, Sabine Dölle
This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. A meta-analysis on recent trends in insect venom anaphylaxis demonstrated for the first time that, although data on the efficacy of insect venom immunotherapy is limited, the occurrence of severe reactions upon repeated sting events can be prevented and patients' quality of life improved...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/29202591/venom-immunotherapy-in-patients-with-allergic-reactions-to-insect-stings
#2
Cristoforo Incorvaia, Marina Mauro, Bruna L Gritti, Eleni Makri, Erminia Ridolo
Allergy to Hymenoptera (Apis mellifera, Vespula species, Polistes species, Vespa crabro) venom can be safely and effectively treated by venom immunotherapy (VIT), which in the 40 years since its introduction has been able to prevent reactions to stings, and to treatment as well, though systemic reactions, occasionally severe, are possible. Areas covered: We reviewed the recent literature on VIT by searching in PubMed for the terms "venom immunotherapy" and "Hymenoptera venom immunotherapy" to highlight the current status of VIT and the likely development in the coming years...
December 5, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29171032/immunological-differences-between-insect-venom-allergic-patients-with-and-without-immunotherapy-and-asymptomatically-sensitized-subjects
#3
Lisa Arzt, Danijela Bokanovic, Christoph Schrautzer, Karin Laipold, Christian Möbs, Wolfgang Pfützner, Sereina Annik Herzog, Jutta Vollmann, Norbert Reider, Barbara Bohle, Werner Aberer, Gunter Sturm
BACKGROUND: Currently available tests are unable to distinguish between asymptomatic sensitization and clinically relevant Hymenoptera venom allergy. A reliable serological marker to monitor venom immunotherapy (VIT) does also not exist. Our aim was to find reliable serological markers to predict tolerance to bee and vespid stings. METHODS: We included 77 asymptomatically-sensitized subjects, 85 allergic-patients with acute systemic sting reactions, and 61 allergic-patients currently treated with VIT...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29143203/relapse-of-nephrotic-syndrome-triggered-by-kawasaki-disease
#4
Ryo Maeda, Yukihiko Kawasaki, Shigeo Suzuki, Shinichiro Ohara, Suyama Kazuhide, Mitsuaki Hosoya
Minor infections, allergies, insect bites, and bee stings are commonly reported causes of nephrotic syndrome (NS). Herein, we report, to the best of our knowledge, the first case of NS relapse due to Kawasaki disease (KD). An 8-year-old boy presented with high fever of 4-day duration. He had developed steroid-dependent NS at the age of 4 years and remained in remission after steroid and mizonbin therapy. Renal biopsy, performed at the age of four, showed minimal change (MC) disease. Upon examination, the patient fulfilled 5 of 6 criteria for KD under the Japanese diagnostic guidelines, with positive proteinuria...
November 15, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29125829/bee-or-wasp-sting
#5
Kam Lun Hon, Alexander K C Leung
While jogging in a local park in Hong Kong, a 55-year-old, previously healthy man was stung on the ventral aspect of his right wrist. The tiny stinger was gently removed with nail cutters and examined under a microscope at 80x magni cation; plucking the stinger is ill- advised as this may inject more venom into the wounded site. Two days after stinging, the microscopic appearance of the stinger con rmed the diagnosis to be from a bee instead of a wasp or other insect. A simple method of con rming the nature of insect stings and an overview of Hymenoptera stings and their management are provided herein...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29080787/advances-in-environmental-and-occupational-disorders-2016
#6
William J Sheehan, Jonathan M Gaffin, David B Peden, Robert K Bush, Wanda Phipatanakul
In this review, we highlight recent studies that advance the knowledge and understanding of the effects of various environmental factors and the associated immune responses in patients with allergic diseases. This review will focus on new literature regarding allergic and immune responses to a variety of environmental factors including aeroallergens, stinging insects, fungi, pollutants, viral respiratory infections, climate change, and microbial exposures.
October 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29068939/watch-out-for-wild-animals-a-systematic-review-of-upper-extremity-injuries-caused-by-uncommon-species
#7
REVIEW
Jacqueline S Israel, James E McCarthy, Katherine R Rose, Venkat K Rao
BACKGROUND: Across the world, many species of nondomesticated animals dwell among humans in metropolitan areas. Rare animal bites pose a dilemma for hand surgeons, as they often result in operative injuries and recalcitrant infections. The authors treated an 85-year-old man who experienced severe cellulitis of the index finger following an opossum bite. This case prompted a systematic review of upper extremity injuries caused by species other than dogs, cats, snakes, and insects. METHODS: The authors conducted a systematic review of PubMed and Scopus databases to identify relevant articles published between 1980 and 2016...
November 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29063905/a-rare-case-of-bleeding-disorder-glanzmann-s-thrombasthenia
#8
Jami Swathi, A Gowrishankar, S A Jayakumar, Karun Jain
BACKGROUND: Glanzmann's thrombasthenia (GT) is a rare bleeding disorder, which is characterized by a lack of platelet aggregation. It is characterized by qualitative or quantitative abnormalities of the platelet membrane glycoprotein IIb/IIIa. Physiologically, this platelet receptor normally binds several adhesive plasma proteins, and this facilitates attachment and aggregation of platelets to ensure thrombus formation at sites of vascular injury. The lack of resultant platelet aggregation in GT leads to mucocutaneous bleeding whose manifestation may be clinically variable, ranging from easy bruising to severe and potentially life-threatening hemorrhages...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/29033869/bilinguals-plausibility-judgments-for-phrases-with-a-literal-vs-non-literal-meaning-the-influence-of-language-brokering-experience
#9
Belem G López, Jyotsna Vaid, Sümeyra Tosun, Chaitra Rao
Previous work has shown that prior experience in language brokering (informal translation) may facilitate the processing of meaning within and across language boundaries. The present investigation examined the influence of brokering on bilinguals' processing of two word collocations with either a literal or a figurative meaning in each language. Proficient Spanish-English bilinguals classified as brokers or non-brokers were asked to judge if adjective+noun phrases presented in each language made sense or not...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29027956/combined-venom-gland-transcriptomic-and-venom-peptidomic-analysis-of-the-predatory-ant-odontomachus-monticola
#10
Kohei Kazuma, Keiichi Masuko, Katsuhiro Konno, Hidetoshi Inagaki
Ants (hymenoptera: Formicidae) have adapted to many different environments and have become some of the most prolific and successful insects. To date, 13,258 ant species have been reported. They have been classified into 333 genera and 17 subfamilies. Except for a few Formicinae, Dolichoderinae, and members of other subfamilies, most ant species have a sting with venom. The venoms are composed of formic acid, alkaloids, hydrocarbons, amines, peptides, and proteins. Unlike the venoms of other animals such as snakes and spiders, ant venoms have seldom been analyzed comprehensively, and their compositions are not yet completely known...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/28890861/idiopathic-anaphylaxis
#11
REVIEW
Bright I Nwaru, Sangeeta Dhami, Aziz Sheikh
Idiopathic anaphylaxis is a rare life-threatening disorder with symptoms similar to other forms of anaphylaxis. There is lack of a robust evidence base underpinning the treatment of anaphylaxis and even less so for idiopathic anaphylaxis. Much of the evidence therefore comes from relatively small case series and expert opinion. Idiopathic anaphylaxis is a diagnosis of exclusion, requiring a thorough history and careful diagnostic work-up investigating possible triggers and underlying predisposing factors. Key diagnostic tests include skin-prick testing, tests for specific-IgE, component-resolved diagnostics, and in some cases for allergen challenge tests...
2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28802075/overcoming-severe-adverse-reactions-to-venom-immunotherapy-by-using-anti-ige-antibodies-in-combination-with-a-high-maintenance-dose
#12
Eva Stretz, Eva Maria Oppel, Räwer Helen-Caroline, René Chatelain, Sebastian Mastnik, Bernhard Przybilla, Franziska Ruëff
BACKGROUND: An omalizumab treatment and a high maintenance venom dose may both help to prevent recurrent systemic allergic reactions (SAR) to venom immunotherapy (VIT). The effectiveness of this combination therapy, however, is unclear. OBJECTIVE: We wanted to explore the possibility whether a temporary treatment with the anti-IgE antibody omalizumab, combined with a VIT using an elevated maintenance dose of >100 μg venom may establish a permanent tolerance of maintenance VIT...
August 12, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28796121/climate-changes-and-hymenoptera-venom-allergy-are-there-some-connections
#13
Stefano Turillazzi, Francesco Turillazzi
PURPOSE OF REVIEW: This review aims to update the world status of the main allergenic stinging Hymenoptera. RECENT FINDINGS: In this review, we consider the problems that social Hymenoptera (bees, wasps and ants) could represent in the nearest future for human health in different parts of the world. SUMMARY: Distribution and consistency of allergenic species including venomous insects are interested by accelerated dynamics caused by climate changes and globalization...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28780941/the-pathophysiology-of-anaphylaxis
#14
REVIEW
Laurent L Reber, Joseph D Hernandez, Stephen J Galli
Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset; characterized by life-threatening airway, breathing, and/or circulatory problems; and usually associated with skin and mucosal changes. Because it can be triggered in some persons by minute amounts of antigen (eg, certain foods or single insect stings), anaphylaxis can be considered the most aberrant example of an imbalance between the cost and benefit of an immune response. This review will describe current understanding of the immunopathogenesis and pathophysiology of anaphylaxis, focusing on the roles of IgE and IgG antibodies, immune effector cells, and mediators thought to contribute to examples of the disorder...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28753659/melanic-variation-underlies-aposematic-color-variation-in-two-hymenopteran-mimicry-systems
#15
Heather M Hines, Paige Witkowski, Joseph S Wilson, Kazumasa Wakamatsu
The stinging hymenopteran velvet ants (Mutillidae) and bumble bees (Apidae: Bombus spp.) have both undergone extensive diversification in aposematic color patterns, including yellow-red hues and contrasting dark-light body coloration, as a result of Müllerian mimicry. Understanding the genetic and developmental mechanisms underlying shifts in these mimetic colors requires characterization of their pigmentation. In this study, a combination of solubility, spectrophotometry, and melanin degradation analysis are applied to several color forms and species of these lineages to determine that orange-red colors in both lineages are comprised of primarily dopamine-derived pheomelanins...
2017: PloS One
https://www.readbyqxmd.com/read/28736112/delayed-stinging-insect-reactions
#16
Elissa M Abrams, Allan B Becker
No abstract text is available yet for this article.
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28701251/recognition-and-management-of-anaphylaxis-in-older-adults
#17
REVIEW
Anastasiya Plagova, Diane Nykamp
OBJECTIVES: To discuss medications that cause anaphylaxis in older adults and its treatment, with a focus on epinephrine. DATA SOURCE: A search of PubMed using the terms "anaphylaxis," "drug-induced anaphylaxis," "epinephrine autoinjectable," "anaphylaxis diagnosis," "anaphylaxis treatment," and "epinephrine cost" was performed. English-language articles from January 2000 to August 2016 appearing in these searches were reviewed. STUDY SELECTION/DATA EXTRACTION: Relevant review articles, consensus statements, practice parameters, task force recommendations, and original articles were assessed for recognition and treatment of drug-induced anaphylaxis...
July 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28686638/which-immunotherapy-product-is-better-for-patients-allergic-to-polistes-venom-a-laboratory-and-clinical-study
#18
Eleonora Savi, Cristoforo Incorvaia, Elisa Boni, Marina Mauro, Silvia Peveri, Valerio Pravettoni, Oliviero Quercia, Federico Reccardini, Marcello Montagni, Laura Pessina, Erminia Ridolo
BACKGROUND: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline...
2017: PloS One
https://www.readbyqxmd.com/read/28672315/anaphylaxis-and-insect-stings-and-bites
#19
(no author information available yet)
No abstract text is available yet for this article.
July 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28662124/individual-perception-of-bees-between-perceived-danger-and-willingness-to-protect
#20
Mona Lisa Schönfelder, Franz Xaver Bogner
The current loss of biodiversity has found its way into the media. Especially the loss of bees as pollinators has recently received much attention aiming to increase public awareness about the consequence of pollinator loss and strategies for protection. However, pollinating insects like bees often prompt considerable anxiety. Negative emotions such as fear and disgust often lead to lack of support for conservation and appropriate initiatives for protection. Our study monitored perceptions of bees in the contexts of conservation and danger bees possibly represent by applying a semantic differential using contrasting adjectives under the heading "I think bees are…"...
2017: PloS One
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