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https://www.readbyqxmd.com/read/29875158/stimulator-of-interferon-genes-sting-provides-insect-antiviral-immunity-by-promoting-dredd-caspase-mediated-nf-kb-activation
#1
Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He, Qingyou Xia, Fei Wang
The antiviral cyclic GMP-AMP (cGAMP)-STimulator of Interferon Genes (STING) pathway is well characterized in mammalian cells. However, whether this pathway also plays a role in insect antiviral immunity is unknown. In this study, we found that cGAMP is produced in silkworm (Bombyx mori) cells infected with nucleopolyhedrovirus (NPV). In searches for STING-related sequences, we identified BmSTING, a potential cGAMP sensor in B. mori. We observed that BmSTING overexpression effectively inhibits NPV replication in silkworm larvae, whereas dsRNA-mediated BmSTING knockdown resulted in higher viral load...
June 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29793621/cooling-the-itch-via-trpm8
#2
Boyi Liu, Sven-Eric Jordt
Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.
June 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29782951/clinical-consequences-of-toxic-envenomations-by-hymenoptera
#3
Justin O Schmidt
Many familiar Hymenoptera are brightly colored and can sting painfully-thus, their threat and clinical importance may be exaggerated. Most stinging insects only sting to defend themselves or their colonies from predators. The clinical nature of Hymenoptera envenomations contrasts that of other venomous animals, including other arthropods, primarily because allergic reaction, not direct intoxication, is the usual main concern. This review focuses mainly on the clinical features of direct toxicity to Hymenoptera envenomations, which can induce a high incidence of acute renal failure, liver failure, multiple organ failures, and death...
May 18, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29775065/maldi-imaging-analysis-of-neuropeptides-in-africanized-honeybee-apis-mellifera-brain-effect-of-aggressiveness
#4
Marcel Pratavieira, Anally Ribeiro da Silva Menegasso, Franciele Grego Esteves, Kenny Umino Sato, Osmar Malaspina, Mario Sérgio Palma
The aggressiveness in honeybees seems to be regulated by multiple genes, under the influence of different factors, such as polyethism of workers, environmental factors, and response to alarm pheromones, creating a series of behavioral responses. It is suspected that neuropeptides seem to be involved with the regulation of the aggressive behavior. The role of allatostatin and tachykinin-related neuropeptides in honeybee brain during the aggressive behavior is unknown; thus, worker honeybees were stimulated to attack and to sting leather targets hanged in front of the colonies...
May 18, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29701628/seroprevalence-survey-of-arboviruses-in-workers-from-tuscany-italy
#5
Maria Elena Remoli, Cristiano Fiorentini, Antonella Marchi, Simona Di Renzi, Nicoletta Vonesch, Maria Vittoria Peri, Lucia Bastianini, Sonia Rossi, Giulia Bartoccini, Maya Lissa Kuttappasery, Maria Grazia Ciufolini, Paola Tomao
BACKGROUND: Arthropod-borne viruses (Arbovirus) play an important role among emerging and re-emerging infectious diseases and in the spreading of infections in new geographic areas. Although some arboviral infections may be asymptomatic or mild flu-like illnesses, many occur as severe forms of meningitis and meningoencephalitis. OBJECTIVES: To assess whether arboviral infections may be associated with occupational risk, in a population of agricultural and forestry workers potentially at high risk for arthropods bite and sting...
January 30, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29649812/safety-and-efficacy-of-a-progressively-prolonged-maintenance-interval-of-venom-immunotherapy
#6
Kalliopi Kontou-Fili, Constantinos Pitsios, Evangelia Kompoti, Dionysios Giannakopoulos, Spyros Kouridakis
BACKGROUND: The long-term protection provided by venom immunotherapy (VIT) is related to the dose administered and to its long duration; the latter, however, becomes inconvenient for patients in countries like Greece, with many islanders or inhabitants of distant mountainous areas. Maintenance interval prolongation reduces the number of office visits - saving time and money - and as a consequence contributes to the patients' compliance. The aim of this prospective study was to evaluate the safety and efficacy of VIT on a progressively prolonged maintenance interval (PPMI)...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29642950/melliferous-insects-and-the-uses-assigned-to-their-products-in-the-northern-yungas-of-salta-argentina
#7
Fabio Fernando Flores, Norma Inés Hilgert, Liliana Concepción Lupo
BACKGROUND: The order Hymenoptera comprises melliferous insects (bees, wasps and bumblebees); among them, stingless bees comprise a diverse group of eusocial insects present in tropical and subtropical areas. Of a total of approximately 500 species, 400 are found in the Neotropics. On the continent of America, before the introduction of Apis mellifera, these insects represented the main source of honey and wax. In Argentina, ethnobiological investigations had been carried out on this group of insects, principally in the Atlantic Forest and Chaco regions...
April 11, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29605550/purification-and-biochemical-characterization-of-vest1s-a-novel-phospholipase-a1-isoform-isolated-from-the-venom-of-the-greater-banded-wasp-vespa-tropica
#8
Prapenpuksiri Rungsa, Steve Peigneur, Sakda Daduang, Jan Tytgat
Vespa tropica, a social wasp locally found in Thailand is responsible for many out off the record accidental stings due to close encounters with human activities and because of the animal's highly potent venom. Phospholipase (PLA) is one of the major proteins commonly found in insect venom. In this work, V. tropica phospholipase was successfully isolated, purified and characterized. Three isoforms PLAs have been purified using reversed phase HPLC, and are named VesT1s (VesT1.01a, VesT1.01b and VesT1.02). They are not glycoproteins...
June 15, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29599674/epidemiology-of-urticaria-in-poland-nationally-representative-survey-results
#9
Filip Raciborski, Anna Kłak, Magdalena Czarnecka-Operacz, Dorota Jenerowicz, Adam Sybilski, Piotr Kuna, Bolesław Samoliński, Eup Wg
Introduction: The prevalence of urticaria is 15-20%. Women are twice as likely to be affected. Aim: To present the epidemiology of urticaria and angioedema in Poland. Material and methods: A questionnaire-based survey was conducted on a representative group of 4,897 individuals, aged 15-74 years. Results: A total of 11.2% of respondents reported at least one episode of urticaria symptoms in their life, and the frequency was higher in females (OR = 1...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29513849/hymenoptera-stings-in-brazil-a-neglected-health-threat-in-amazonas-state
#10
Allyson Guimarães Costa, Bárbara Aparecida Chaves, Felipe Leão Gomes Murta, Jacqueline Almeida Gonçalves Sachett, Vanderson Souza Sampaio, Vanessa Costa Silva, Wuelton Marcelo Monteiro
INTRODUCTION: Hymenoptera injuries are commonly caused by stinging insects. In Amazonas state, Brazil, there is no information regarding distribution, profile, and systemic manifestations associated with Hymenoptera injuries. METHODS: This study aimed to identify risk factors for systemic manifestation using the Brazilian Notifiable Diseases Surveillance System (2007 to 2015). RESULTS: Half of Hymenoptera injuries were caused by bee stings...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29467580/history-of-morgellons-disease-from-delusion-to-definition
#11
REVIEW
Marianne J Middelveen, Melissa C Fesler, Raphael B Stricker
Morgellons disease (MD) is a skin condition characterized by the presence of multicolored filaments that lie under, are embedded in, or project from skin. Although the condition may have a longer history, disease matching the above description was first reported in the US in 2002. Since that time, the condition that we know as MD has become a polemic topic. Because individuals afflicted with the disease may have crawling or stinging sensations and sometimes believe they have an insect or parasite infestation, most medical practitioners consider MD a purely delusional disorder...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29407420/changes-in-emergency-department-concordance-with-guidelines-for-the-management-of-stinging-insect-induced-anaphylaxis-1999-2001-vs-2013-2015
#12
Sunday Clark, Krislyn M Boggs, Diana S Balekian, Kohei Hasegawa, Phuong Vo, Brian H Rowe, Carlos A Camargo
BACKGROUND: Changes in emergency department (ED) concordance with guidelines for the management of stinging insect-induced anaphylaxis (SIIA) are not known. OBJECTIVE: To describe temporal changes in ED concordance with guidelines for the management of SIIAs. METHODS: We analyzed data from 2 multicenter retrospective studies of patients with stinging insect-related acute allergic reactions seen in 1 of 14 North American EDs during 2 periods: 1999 through 2001 and 2013 through 2015...
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29399436/current-state-of-follow-up-care-for-patients-with-hymenoptera-venom-anaphylaxis-in-southwest-germany-major-impact-of-early-information
#13
Manisha Manmohan, Sabine Müller, Michèle Myriam Rauber, Frank Koberne, H Reisch, Joachim Koster, Richard Böhm, Martin Messelken, Matthias Fischer, Thilo Jakob
Background: Up to 3.5% of the population experience anaphylactic reactions in response to Hymenoptera stings. Current guidelines are in place for the diagnostic workup and follow-up care of patients with Hymenoptera venom anaphylaxis (HVA). However, little is known about the degree of implementation of the recommendations and patient attitudes toward the recommendations in the general patient population. Methods: For the analysis of the follow-up care in real life, a retrospective questionnaire-based study was conducted in unselected patients who had received treatment from an emergency medical response team for HVA, as documented in records of three regional Medical Emergency Response Centers...
2018: Allergo Journal International
https://www.readbyqxmd.com/read/29377078/impact-of-climate-change-on-dermatological-conditions-related-to-flooding-update-from-the-international-society-of-dermatology-climate-change-committee
#14
REVIEW
Johannes F Dayrit, Lunardi Bintanjoyo, Louise K Andersen, Mark Dennis P Davis
Climate change contributes to the increase in severity and frequency of flooding, which is the most frequent and deadly disaster worldwide. Flood-related damage can be very severe and include health effects. Among those health impacts, dermatological diseases are one of the most frequently encountered. Both infectious and noninfectious dermatological conditions are increasing after flooding. We searched PubMed using the search term climate change OR global warming OR rainfall OR flooding OR skin. Articles published in the English-language literature were included...
January 29, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29338154/characteristics-etiology-and-treatment-of-pediatric-and-adult-anaphylaxis-in-iran
#15
Mohammad Nabavi, Mehrnoosh Lavavpour, Saba Arshi, Mohammad Hasan Bemanian, Hossein Esmaeilzadeh, Rasool Molatefi, Mahsa Rekabi, Javad Ahmadian, Narges Eslami, Sima Shokri, Kian Darabi, Gholam Reza Sedighi, Morteza Fallahpour
Despite the increasing prevalence of anaphylaxis, there is little information about the characteristics and practice of healthcare providers in treating anaphylaxis, so this study was conducted to record the characteristics and therapeutic approaches of anaphylaxis from May 2012 until April 2015, the data of all patients diagnosed with anaphylaxis in the Allergy department of three referral university hospitals in Tehran, Iran were recorded. Thereafter, the demographics, clinical features, triggers and therapeutic approach were evaluated...
December 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#16
REVIEW
S Blank, M B Bilò, M Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29301119/cause-and-clinical-presentation-of-anaphylaxis-in-singapore-from-infancy-to-old-age
#17
Si Hui Goh, Jian Yi Soh, Wenyin Loh, Khai Pin Lee, Sze Chin Tan, Wei Jian Kenneth Heng, Irwani Ibrahim, Bee Wah Lee, Wen Chin Chiang
BACKGROUND: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis. METHODS: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Patient electronic records with the diagnoses of allergy, angioedema, urticaria, and anaphylaxis (ICD-9 codes 9953, 9951, 7080, 9950, 7089) were screened and cases fulfilling World Allergy Organisation criteria for anaphylaxis were included...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29276560/envenomation-seizures
#18
Ghulam Abbas Kharal, Richard Ryan Darby, Adam B Cohen
Insect sting-related envenomation rarely produces seizures. We present a patient with confusion and seizures that began 24 hours after a yellow jacket (wasp) sting. Given the rapid onset and resolution of symptoms, as well as accompanying dermatological and orbital features, and the lack of any infectious or structural abnormalities identified, the toxic effect of the wasp venom (and related anaphylaxis reaction) was believed to be the cause of his presentation.
January 2018: Neurohospitalist
https://www.readbyqxmd.com/read/29214141/new-trends-in-anaphylaxis
#19
REVIEW
Margitta Worm, Gunter Sturm, Jörg Kleine-Tebbe, Ewa Cichocka-Jarosz, Victoria Cardona, Ioana Maris, Sabine Dölle
This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. A meta-analysis on recent trends in insect venom anaphylaxis demonstrated for the first time that, although data on the efficacy of insect venom immunotherapy is limited, the occurrence of severe reactions upon repeated sting events can be prevented and patients' quality of life improved...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/29202591/venom-immunotherapy-in-patients-with-allergic-reactions-to-insect-stings
#20
Cristoforo Incorvaia, Marina Mauro, Bruna L Gritti, Eleni Makri, Erminia Ridolo
Allergy to Hymenoptera (Apis mellifera, Vespula species, Polistes species, Vespa crabro) venom can be safely and effectively treated by venom immunotherapy (VIT), which in the 40 years since its introduction has been able to prevent reactions to stings, and to treatment as well, though systemic reactions, occasionally severe, are possible. Areas covered: We reviewed the recent literature on VIT by searching in PubMed for the terms 'venom immunotherapy' and 'Hymenoptera venom immunotherapy' to highlight the current status of VIT and the likely development in the coming years...
January 2018: Expert Review of Clinical Immunology
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