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https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#1
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747191/implementation-findings-from-a-hybrid-iii-implementation-effectiveness-trial-of-the-diabetes-prevention-program-dpp-in-the-veterans-health-administration-vha
#2
Laura J Damschroder, Caitlin M Reardon, Mona AuYoung, Tannaz Moin, Santanu K Datta, Jordan B Sparks, Matthew L Maciejewski, Nanette I Steinle, Jane E Weinreb, Maria Hughes, Lillian F Pinault, Xinran M Xiang, Charles Billington, Caroline R Richardson
BACKGROUND: The Diabetes Prevention Program (DPP) is an effective lifestyle intervention to reduce incidence of type 2 diabetes. However, there are gaps in knowledge about how to implement DPP. The aim of this study was to evaluate implementation of DPP via assessment of a clinical demonstration in the Veterans Health Administration (VHA). METHODS: A 12-month pragmatic clinical trial compared weight outcomes between the Veterans Affairs Diabetes Prevention Program (VA-DPP) and the usual care MOVE!® weight management program (MOVE!)...
July 26, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28746700/risk-factors-for-melanoma-in-renal-transplant-recipients
#3
Mona Ascha, Mustafa S Ascha, Joseph Tanenbaum, Jeremy S Bordeaux
Importance: Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective: To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants: This cohort study of a large national data registry used a cohort of renal transplant recipients from the United States Renal Data System (USRDS) database from the years 2004 through 2012...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28745235/effects-of-ascorbic-acid-on-tax-nf-%C3%AE%C2%BAb-and-mmp-9-in-human-t-cell-lymphotropic-virus-type-1-positive-malignant-t-lymphocytes
#4
Steve Harakeh, Jihane Khalife, Elias Baydoun, Rania Azar, Ahmed Al-Hejin, Elie Barbour, Esam Azhar, Aleksandra Niedzwiecki, Soad Al Jaouni, Mona Diab-Assaf, Mohammad Amjad Kamal, Mathias Rath
BACKGROUND: HTLV-1 is a retrovirus that infects CD4-positive cells and leads to Adult T-cell leukemia by constitutive activation of nuclear factor kappa B. Ascorbic acid (AA) is an essential nutrient that possess anti-proliferative and pro-apoptotic activity against a number of malignant cell lines. This study delineates the effect of AA on Tax protein expression as well as NF-κB and MMP9 activity in two HTLV-1-positive leukemia cells (HuT-102 and C91-PL). METHODS: The cytotoxic and antiproliferative effect of AA were studied by LDH release and MTT tests respectively...
July 25, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28745107/effectiveness-of-psychotherapy-in-adult-adhd-what-do-patients-think-results-of-the-compas-study
#5
Vivien Groß, Caroline Lücke, Erika Graf, Alexandra P Lam, Swantje Matthies, Patricia Borel, Esther Sobanski, Michael Rösler, Wolfgang Retz, Christian Jacob, Michael Colla, Michael Huss, Thomas Jans, Bernhard Kis, Mona Abdel-Hamid, Ludger Tebartz van Elst, Alexandra Philipsen
OBJECTIVE: In the multicenter study Comparison of Methylphenidate and Psychotherapy in Adult ADHD (COMPAS), the efficacy of treatments has been primarily evaluated by observer-rated symptom change. Here, we additionally analyzed the patients' subjective evaluation of therapy effects. METHOD: COMPAS compared ADHD-specific group therapy with unspecific clinical management with/without concomitant pharmacotherapy in a four-armed design. Evaluation through the patients' retrospective perspective was performed after 1 year (post-treatment) and after another 1...
July 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28741232/serum-and-aqueous-humor-concentrations-of-interleukin-27-in-diabetic-retinopathy-patients
#6
Maha E Houssen, Mona Abo Bakr El-Hussiny, Amr El-Kannishy, Dalia Sabry, Rasha El Mahdy, Mohamed E Shaker
PURPOSE: Interleukin (IL)-27 has been reported to possess anti- and proinflammatory properties in several immune related-disorders, but its role in diabetic retinopathy is still elusive. Here, we aimed to (i) evaluate IL-27 concentrations in serum and aqueous humor of diabetic patients with or without retinopathy and (ii) test whether IL-27 is correlated with some risk factors of diabetic retinopathy. METHODS: The study comprised 60 diabetic patients with and without retinopathy along with 20 healthy controls...
July 24, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28740415/the-extracellular-matrix-of-eggshell-displays-anti-inflammatory-activities-through-nf-%C3%AE%C2%BAb-in-lps-triggered-human-immune-cells
#7
Tram T Vuong, Sissel B Rønning, Henri-Pierre Suso, Ralf Schmidt, Kristian Prydz, Marlene Lundström, Anders Moen, Mona E Pedersen
Avian eggshell membrane (ESM) is a natural biomaterial that has been used as an alternative natural bandage on burned and cut skin injuries for >400 years in Asian countries, and is available in large quantities from egg industries. Our aim was to characterize ESM that was separated and processed from egg waste, and to study whether this material possesses anti-inflammatory properties, making it suitable as an ingredient in industrial production of low cost wound healing products. Our results show that the processed ESM particles retain a fibrous structure similar to that observed for the native membrane, and contain collagen, and carbohydrate components such as hyaluronic acid and sulfated glycosaminoglycans, as well as N-glycans, mostly with uncharged structures...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/28736994/intraoperative-hemodynamic-factors-predicting-early-postoperative-renal-function-in-pediatric-kidney-transplantation
#8
Daphné Michelet, Christopher Brasher, Lucile Marsac, Nabil Zanoun, Mona Assefi, Alaa Elghoneimi, Stephane Dauger, Souhayl Dahmani
BACKGROUND: The anesthetic management of kidney transplantation in children remains somewhat empirical. The goal of the present study was to investigate intraoperative hemodynamic factors affecting posttransplantation kidney function. METHODS: We performed a retrospective analysis of data from patients undergoing kidney transplantation in our pediatric teaching hospital from 2000 to 2014. Data collected included: donor and recipient demographic data, recipient comorbidities, fluids administered intraoperatively, and intraoperative blood pressure and central venous pressure...
July 24, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28736667/changes-in-optical-properties-of-electroporated-cells-as-revealed-by-digital-holographic-microscopy
#9
Violeta L Calin, Mona Mihailescu, Nicolae Mihale, Alexandra V Baluta, Eugenia Kovacs, Tudor Savopol, Mihaela G Moisescu
Changes in optical and shape-related characteristics of B16F10 cells after electroporation were investigated using digital holographic microscopy (DHM). Bipolar rectangular pulses specific for electrochemotherapy were used. Electroporation was performed in an "off-axis" DHM set-up without using exogenous markers. Two types of cell parameters were monitored seconds and minutes after pulse train application: parameters addressing a specifically defined area of the cell (refractive index and cell height) and global cell parameters (projected area, optical phase shift profile and dry mass)...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28735327/genotyping-and-clinicoepidemiological-characterization-of-rotavirus-acute-gastroenteritis-in-egyptian-children
#10
Niveen Saudy, Walaa Othman Elshabrawy, Ahmed Megahed, Mona F Foad, Aly F Mohamed
Group A rotavirus (RVA) acute gastroenteritis (AGE) is a common cause of severe childhood diarrhea. The dominant circulating RVA genotypes in a given region may vary between and within the geographic regions and from year to year. Our cross-sectional study was designed to determine the burden of RVA genotypes among children with AGE admitted to referral Children Hospital at Egypt prior to implementation of the vaccine. Stool samples with clinico-epidemiological data were collected from 92 children ≤ 3 years-old with AGE...
January 2, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28735317/genetic-characterization-of-a-novel-composite-transposon-carrying-arma-and-aac-6-ib-genes-in-an-escherichia-coli-isolate-from-egypt
#11
Mona T Kashef, Omneya M Helmy
Aminoglycosides are used in treating a wide range of infections caused by Gram-positive and Gram-negative bacteria; however, aminoglycoside resistance is common and occurs by several mechanisms. Among these mechanisms is bacterial rRNA methylation by the 16S rRNA methyl transferase (16S-RMTase) enzymes; but data about the spread of this mechanism in Egypt are scarce. Cephalosporins are the most commonly used antimicrobial agents in Egypt; therefore, this study was conducted to determine the frequency of 16S-RMTase among third generation cephalosporin-resistant clinical isolates in Egypt...
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28733919/substance-use-violence-and-antiretroviral-adherence-a-latent-class-analysis-of-women-living-with-hiv-in-canada
#12
Allison Carter, Eric Abella Roth, Erin Ding, M-J Milloy, Mary Kestler, Shahab Jabbari, Kath Webster, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
We used latent class analysis to identify substance use patterns for 1363 women living with HIV in Canada and assessed associations with socio-economic marginalization, violence, and sub-optimal adherence to combination antiretroviral therapy (cART). A six-class model was identified consisting of: abstainers (26.3%), Tobacco Users (8.81%), Alcohol Users (31.9%), 'Socially Acceptable' Poly-substance Users (13.9%), Illicit Poly-substance Users (9.81%) and Illicit Poly-substance Users of All Types (9.27%). Multinomial logistic regression showed that women experiencing recent violence had significantly higher odds of membership in all substance use latent classes, relative to Abstainers, while those reporting sub-optimal cART adherence had higher odds of being members of the poly-substance use classes only...
July 21, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28733712/fertility-and-ploidy-of-gametes-of-allodiploid-and-allotriploid-loaches-produced-by-diploid-misgurnus-anguillicaudatus-females-and-paramisgurnus-dabryanus-males
#13
Songqian Huang, Xiaojuan Cao, Weimin Wang, Mona Nasr
Artificial and natural hybridization of dojo loach Misgurnus anguillicaudatus (2N = 50, DD for short) and large-scale loach Paramisgurnus dabryanus (2N = 48, PP for short) are well-grown. However, these hybrid loaches have not yet been examined for fertility and ploidy of gametes. Here, histological observations, artificial propagation, observations of embryonic development, larval morphology, and ploidy analyses were conducted to determine the fertility and ploidy of gametes of allodiploid (DP for short) and allotriploid (DDP for short) loaches, produced by DD females × PP males and induced from fertilized eggs of DD females × PP males by cold shock to prevent the second polar body release, respectively...
July 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28733386/mir-99-regulates-normal-and-malignant-hematopoietic-stem-cell-self-renewal
#14
Mona Khalaj, Carolien M Woolthuis, Wenhuo Hu, Benjamin H Durham, S Haihua Chu, Sarah Qamar, Scott A Armstrong, Christopher Y Park
The microRNA-99 (miR-99) family comprises a group of broadly conserved microRNAs that are highly expressed in hematopoietic stem cells (HSCs) and acute myeloid leukemia stem cells (LSCs) compared with their differentiated progeny. Herein, we show that miR-99 regulates self-renewal in both HSCs and LSCs. miR-99 maintains HSC long-term reconstitution activity by inhibiting differentiation and cell cycle entry. Moreover, miR-99 inhibition induced LSC differentiation and depletion in an MLL-AF9-driven mouse model of AML, leading to reduction in leukemia-initiating activity and improved survival in secondary transplants...
July 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28732514/in-vitro-assessment-of-the-antimicrobial-activity-of-silver-and-zinc-oxide-nanoparticles-against-fish-pathogens
#15
Mohamed Ibrahim Shaalan, Magdy Mohamed El-Mahdy, Sarah Theiner, Mansour El-Matbouli, Mona Saleh
BACKGROUND: Antibiotic resistance is a global issue that threatens public health. The excessive use of antibiotics contributes to this problem as the genes of antibiotic resistance can be transferred between the bacteria in humans, animals and aquatic organisms. Metallic nanoparticles could serve as future substitutes for some conventional antibiotics because of their antimicrobial activity. The aim of this study was to evaluate the antimicrobial effects of silver and zinc oxide nanoparticles against major fish pathogens and assess their safety in vitro...
July 21, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28730087/frequency-of-diabetic-retinopathy-and-associated-risk-factors-in-khartoum-sudan-population-based-study
#16
Einas S Elwali, Ahmed O Almobarak, Mona A Hassan, Amir A Mahmooud, Heitham Awadalla, Mohamed H Ahmed
AIM: To assess the frequency and associated risk factors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METHODS: The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure HbA1c and lipid profile...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727731/pregnancy-incidence-and-intention-after-hiv-diagnosis-among-women-living-with-hiv-in-canada
#17
Kate Salters, Mona Loutfy, Alexandra de Pokomandy, Deborah Money, Neora Pick, Lu Wang, Shahab Jabbari, Allison Carter, Kath Webster, Tracey Conway, Daniele Dubuc, Nadia O'Brien, Karene Proulx-Boucher, Angela Kaida
BACKGROUND: Pregnancy incidence rates among women living with HIV (WLWH) have increased over time due to longer life expectancy, improved health status, and improved access to and HIV prevention benefits of combination antiretroviral therapy (cART). However, it is unclear whether intended or unintended pregnancies are contributing to observed increases. METHODS: We analyzed retrospective data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)...
2017: PloS One
https://www.readbyqxmd.com/read/28727234/kynurenine-a-tryptophan-metabolite-that-accumulates-with-age-induces-bone-loss
#18
Mona El Refaey, Meghan E McGee-Lawrence, Sadanand Fulzele, Eileen J Kennedy, Wendy B Bollag, Mohammed Elsalanty, Qing Zhong, Ke-Hong Ding, Nathaniel G Bendzunas, Xing-Ming Shi, Jianrui Xu, William D Hill, Maribeth H Johnson, Monte Hunter, Jessica L Pierce, Kanglun Yu, Mark W Hamrick, Carlos M Isales
Age-dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase in the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants and are anabolic for bone and that they may potentially play a protective role in an aging environment. We hypothesized that upon oxidation the aromatic amino acids would not only lose their anabolic effects but also potentially become a catabolic byproduct...
July 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28725128/quality-of-communication-between-dentists-and-dental-laboratory-technicians-for-fixed-prosthodontics-in-riyadh-saudi-arabia
#19
Huda Tulbah, Eman AlHamdan, Amal AlQahtani, Asma AlShahrani, Mona AlShaye
The fabrication of a clinically acceptable dental prosthesis requires proper communication between the dentist and the dental technician. Prosthodontic educators have been concerned with this interaction and communication. Fixed prosthodontics laboratories revealed that the technicians are often dissatisfied with the information provided in work authorizations. OBJECTIVE: To evaluate the quality of communication between dentists and laboratory technicians via work authorizations for fixed prosthodontics in both governmental and private dental laboratories in Riyadh area from the technician's perspective...
July 2017: Saudi Dental Journal
https://www.readbyqxmd.com/read/28721881/final-report-of-a-prospective-randomized-trial-to-evaluate-the-dose-response-relationship-for-postoperative-radiation-therapy-and-pathologic-risk-groups-in-patients-with-head-and-neck%C3%A2-cancer
#20
David I Rosenthal, Abdallah S R Mohamed, Adam S Garden, William H Morrison, Adel K El-Naggar, Mona Kamal, Randal S Weber, Clifton D Fuller, Lester J Peters
PURPOSE: To present the long-term and final report of a phase 3 trial designed to assess dose-response relationship for postoperative radiation therapy (PORT) and pathologic risk groups in head and neck cancer. METHODS AND MATERIALS: Patients who underwent primary surgery for American Joint Committee on Cancer stage III or IV squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx and who required PORT were eligible. Patients' primary sites and involved necks were independently assigned to higher- or lower-risk categories based on a cumulative point score representing increasing risk of recurrence...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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