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https://www.readbyqxmd.com/read/28449114/neuro-symbolic-representation-learning-on-biological-knowledge-graphs
#1
Mona Alshahrani, Mohammed Asif Khan, Omar Maddouri, Akira R Kinjo, Núria Queralt-Rosinach, Robert Hoehndorf
Motivation: Biological data and knowledge bases increasingly rely on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. In the past years, feature learning methods that are applicable to graph-structured data are becoming available, but have not yet widely been applied and evaluated on structured biological knowledge. Results: We develop a novel method for feature learning on biological knowledge graphs...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28448253/a-map-of-abstract-relational-knowledge-in-the-human-hippocampal-entorhinal-cortex
#2
Mona M Garvert, Raymond J Dolan, Timothy Ej Behrens
The hippocampal-entorhinal system encodes a map of space that guides spatial navigation. Goal-directed behaviour outside of spatial navigation similarly requires a representation of abstract forms of relational knowledge. This information relies on the same neural system, but it is not known whether the organisational principles governing continuous maps may extend to the implicit encoding of discrete, non-spatial graphs. Here, we show that the human hippocampal-entorhinal system can represent relationships between objects using a metric that depends on associative strength...
April 27, 2017: ELife
https://www.readbyqxmd.com/read/28447032/risk-of-sleepiness-related-accidents-in-switzerland-results-of-an-online-sleep-apnea-risk-questionnaire-and-awareness-campaigns
#3
Mona Lichtblau, Daniel Bratton, Philippe Giroud, Thomas Weiler, Konrad E Bloch, Thomas Brack
OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is associated with major morbidity and mortality but OSAS is frequently under recognized. To promote awareness of OSAS, the Swiss Lung League launched an online questionnaire combined with annual advertisements in mass media. Characteristics of participants, prevalence of sleep apnea, OSAS-related symptoms, and their association with accidents were investigated. METHODS: A questionnaire was created incorporating anthropometrics, the Epworth sleepiness scale (ESS), the OSAS domain of the sleep disorders questionnaire (SDQ), and a question on accidents related to sleepiness...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28445970/acid-ceramidase-is-a-novel-drug-target-for-pediatric-brain-tumors
#4
Ninh B Doan, Ha S Nguyen, Andrew Montoure, Mona M Al-Gizawiy, Wade M Mueller, Shekar Kurpad, Scott D Rand, Jennifer M Connelly, Christopher R Chitambar, Kathleen M Schmainda, Shama P Mirza
Pediatric brain tumors are the most common solid tumors in children and are also a leading culprit of cancer-related fatalities in children. Pediatric brain tumors remain hard to treat. In this study, we demonstrated that medulloblastoma, pediatric glioblastoma, and atypical teratoid rhabdoid tumors express significant levels of acid ceramidase, where levels are highest in the radioresistant tumors, suggesting that acid ceramidase may confer radioresistance. More importantly, we also showed that acid ceramidase inhibitors are highly effective at targeting these pediatric brain tumors with low IC50 values (4...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28444518/video-based-approach-to-engaging-parents-into-a-preventive-parenting-intervention-for-divorcing-families-results-of-a-randomized-controlled-trial
#5
Emily B Winslow, Sanford Braver, Robert Cialdini, Irwin Sandler, Jennifer Betkowski, Jenn-Yun Tein, Liza Hita, Mona Bapat, Lorey Wheeler, Monique Lopez
The public health impact of evidence-based, preventive parenting interventions has been severely constrained by low rates of participation when interventions are delivered under natural conditions. It is critical that prevention scientists develop effective and feasible parent engagement methods. This study tested video-based methods for engaging parents into an evidence-based program for divorcing parents. Three alternative versions of a video were created to test the incremental effectiveness of different theory-based engagement strategies based on social influence and health behavior models...
April 25, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28444470/sexual-orientation-differences-in-health-and-wellbeing-among-women-living-with-hiv-in-canada-findings-from-a-national-cohort-study
#6
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Alexandra de Pokomandy, Kath Webster, Tracey Conway, Mona Loutfy
Sexual orientation differences in health and wellbeing among women living with HIV (WLH) are underexplored. Limited research available, however, suggests that sexual minority WLH may experience barriers to HIV care. Cross-sectional baseline data was analyzed from a Canadian cohort study with WLH (sexual minority women [SMW]: n = 180; heterosexual women: n = 1240). SMW (median age 38 years, IQR 13) included bisexual (58.9%), lesbian (17.8%) and other sexualities (23.3%). In multivariable analyses adjusting for age, poverty, education, and ethnicity, SMW identity was associated with increased odds of: clinical (80% vs...
April 25, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28443224/the-effect-of-lactobacillus-acidophilus-ptcc-1643-on-cultured-intestinal-epithelial-cells-infected-with-salmonella-enterica-serovar-enteritidis
#7
Mona Moshiri, Mohammad Mehdi Soltan Dallal, Farhad Rezaei, Masoumeh Douraghi, Laleh Sharifi, Zahra Noroozbabaei, Mehrdad Gholami, Abbas Mirshafiey
OBJECTIVES: Gastrointestinal disorders caused by Salmonella enterica serovar Enteritidis (SesE) are a significant health problem around the globe. Probiotic bacteria have been shown to have positive effects on the immune responses. Lactobacillus acidophilus was examined for its capability to influence the innate immune response of HT29 intestinal epithelial cells towards SesE. The purpose of this work was to assess the effect of L. acidophilus PTCC 1643 on cultured intestinal epithelial cells infected with SesE...
February 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28442800/what-puts-them-at-risk-a-cross-sectional-case-control-survey-of-demographic-profile-and-sexual-behavior-of-patients-with-sexually-transmitted-infections-at-a-tertiary-care-center-in-north-india
#8
Rama Raj, Vishal Gupta, Mona Pathak, Vishnubhatla Sreenivas, Seema Sood, Sarman Singh, Kaushal K Verma, Neena Khanna, Bimal K Das, Somesh Gupta
BACKGROUND: Sexually transmitted infections (STIs) are a major public health problem in developing nations. Identification of risk factors can help in formulating effective strategies against them. The present study was conducted in a tertiary care hospital in North India over 1 year to identify the risk factors associated with STIs. MATERIALS AND METHODS: A questionnaire-based cross-sectional case-control survey was conducted where participants answered questions on demographic details, sexual behavior, and awareness of STIs...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28441442/the-effects-of-a-resistance-vs-an-aerobic-single-session-on-attention-and-executive-functioning-in-adults
#9
Ayelet Dunsky, Mona Abu-Rukun, Sharon Tsuk, Tzvi Dwolatzky, Rafi Carasso, Yael Netz
Evidence from recent studies showed that acute aerobic exercise results in improvements in different cognitive functions. The goal of this study was to assess the influence of acute bouts of aerobic versus resistance exercise on attention and executive function in adults. Thirty-nine physically active adults (age = 52±8 yr) served as participants. Each participant visited the laboratory four times: on the first visit participants performed a cognitive test (NeuroTrax) followed by an aerobic fitness assessment, as well as maximal strength test composed of six exercises...
2017: PloS One
https://www.readbyqxmd.com/read/28438682/production-immobilization-and-thermodynamic-studies-of-free-and-immobilized-aspergillus-awamori-amylase
#10
Eman A Karam, Walaa A Abdel Wahab, Shireen A A Saleh, Mohamed E Hassan, Amany L Kansoh, Mona A Esawy
Enzyme cost, stability and its thermodynamic characteristics are the main criteria for industrial use. In this study, Aspergillus awamori amylase was constitutively produced using various agro-industrial wastes. Olive oil cake gave the highest activity (230 U/g). The amylase was partially purified to 2.81 fold purification. Immobilization was achieved using different carriers by covalent binding. The novel carrier Ca(+2) alginate (Alg) starch (St)/ polyethyleneimine (PEI)/glutaraldehyde (GA), showed the highest operational stability and was selected for further studies...
April 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28437891/the-therapeutic-effect-of-nano-encapsulated-and-nano-emulsion-forms-of-carvacrol-on-experimental-liver-fibrosis
#11
Jihan Hussein, Mona El-Banna, Khaled F Mahmoud, Safaa Morsy, Yasmin Abdel Latif, Dalia Medhat, Eman Refaat, Abdel Razik Farrag, Sherien M El-Daly
OBJECTIVE: The present study aimed to compare the therapeutic efficiency of nano-encapsulated and nano-emulsion carvacrol administration on liver injury in thioacetamide (TAA) treated rats. METHODS: To fulfill our target, we used sixty male albino rats classified into six groups as follow: control, nano-encapsulated carvacrol, nano-emulsion carvacrol, thioacetamide, treated nano-encapsulated carvacrol and treated nano-emulsion carvacrol groups. Blood samples were collected from all groups and the separated serum was used for analysis of the following biochemical parameters; aspartate aminotransferase (AST), alanine aminotransferase (ALT), S100 B protein, alpha fetoprotein (AFP) and caspase-3...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28436590/identification-of-small-molecules-using-accurate-mass-ms-ms-search
#12
REVIEW
Tobias Kind, Hiroshi Tsugawa, Tomas Cajka, Yan Ma, Zijuan Lai, Sajjan S Mehta, Gert Wohlgemuth, Dinesh Kumar Barupal, Megan R Showalter, Masanori Arita, Oliver Fiehn
Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS spectra from screening small molecules in fields such as environmental analysis, drug screening, lipid analysis, and metabolomics. The confidence in MS/MS-based annotation of chemical structures is impacted by instrumental settings and requirements, data acquisition modes including data-dependent and data-independent methods, library scoring algorithms, as well as post-curation steps. We critically discuss parameters that influence search results, such as mass accuracy, precursor ion isolation width, intensity thresholds, centroiding algorithms, and acquisition speed...
April 24, 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/28435834/prevalence-of-hiv-in-a-prison-of-tehran-by-active-case-finding
#13
Seyed Ahmad Seyedalinaghi, Behnam Farhoudi, Minoo Mohraz, Mona Mohammadi Firouzeh, Mostafa Hosseini, Kianoush Kamali
No abstract text is available yet for this article.
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28435399/serum-atrial-natriuretic-peptide-a-suspected-biomarker-of-breast-cancer
#14
Maha E Houssen, Hayam F Ghazy, Kamel Farag, Mona Abo Bakr El-Hussiny, Mohamed A El Ghaffar, Sahar Alsayed Mohamed Alsayed, Omar Farouk
AIM OF THE STUDY: To assess serum levels of ANP in breast cancer female patients and its relationship to metastasis and some clinical parameters among those patients. MATERIAL AND METHODS: One hundred breast cancer patients with and without metastasis along with 20 healthy closely matched controls, were enrolled in the present cross sectional study. Background: To assess the serum levels of atrial natriuretic peptide in breast cancer Serum levels of ANP were assessed using ELISA...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28435397/leptin-receptor-q223r-polymorphism-in-egyptian-female-patients-with-breast-cancer
#15
Mona Abo-Bakr El-Hussiny, Mohmed Ali Atwa, Waleed Elnahas Rashad, Dalia A Shaheen, Nora Marzouk Elkady
AIM OF THE STUDY: Breast cancer is the most common cause of death in women. Obesity has been associated with increased risk of breast cancer in post-menopausal women. It induces chronic inflammation, which increases local and systemic levels of cytokines and adipokines such as leptin. Leptin (LEP) and leptin receptor (LEPR) genes have several polymorphisms in humans. This study aims to assess the association between blood levels of leptin and LEPR Q223R gene polymorphism in patients of cancer breast...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28430371/evaluation-of-circulating-zonulin-as-a-potential-marker-in-the-pathogenesis-of-nonalcoholic-fatty-liver-disease
#16
Olfat M Hendy, Maha M Elsabaawy, Mona M Aref, Fatma M Khalaf, Abdel Moaty A Oda, Helmy M El Shazly
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders ranging from simple hepatic steatosis up to nonalcoholic steatohepatitis (NASH) evolving to cirrhosis and hepatocellular carcinoma (HCC). Liver biopsy is still the gold standard modality for diagnosing and staging NAFLD. The linkage between intestinal microbiota and NAFLD, might suggest a potential role of serum zonulin in NAFLD diagnosis. To appraise the role of circulating zonulin in NAFLD pathogenesis, 56 subjects with proved NAFLD by ultrasonography and liver biopsy, as well as 20 healthy controls were tested...
April 21, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28427316/a-multiscale-modelling-approach-to-understand-atherosclerosis-formation-a-patient-specific-case-study-in-the-aortic-bifurcation
#17
Mona Alimohammadi, Cesar Pichardo-Almarza, Obiekezie Agu, Vanessa Díaz-Zuccarini
Atherogenesis, the formation of plaques in the wall of blood vessels, starts as a result of lipid accumulation (low-density lipoprotein cholesterol) in the vessel wall. Such accumulation is related to the site of endothelial mechanotransduction, the endothelial response to mechanical stimuli and haemodynamics, which determines biochemical processes regulating the vessel wall permeability. This interaction between biomechanical and biochemical phenomena is complex, spanning different biological scales and is patient-specific, requiring tools able to capture such mathematical and biological complexity in a unified framework...
May 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28426644/notes-from-the-field-varicella-fatality-on-a-cargo-vessel-puerto-rico-2015
#18
Misty Ellis, Carolina Luna-Pinto, Thomas George, Joanna J Regan, Mona Marin, Adriana Lopez, Brenda Rivera-Garcia, Kara Tardivel
No abstract text is available yet for this article.
April 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28426130/length-of-stay-for-patients-undergoing-invasive-electrode-monitoring-with-stereoelectroencephalography-and-subdural-grids-correlates-positively-with-increased-institutional-profitability
#19
Alvin Y Chan, Sohayla Kharrat, Kelly Lundeen, Lilit Mnatsakanyan, Mona Sazgar, Indranil Sen-Gupta, Jack J Lin, Frank P K Hsu, Sumeet Vadera
OBJECTIVE: Lowering the length of stay (LOS) is thought to potentially decrease hospital costs and is a metric commonly used to manage capacity. Patients with epilepsy undergoing intracranial electrode monitoring may have longer LOS because the time to seizure is difficult to predict or control. This study investigates the effect of economic implications of increased LOS in patients undergoing invasive electrode monitoring for epilepsy. METHODS: We retrospectively collected and analyzed patient data for 76 patients who underwent invasive monitoring with either subdural grid (SDG) implantation or stereoelectroencephalography (SEEG) over 2 years at our institution...
April 20, 2017: Epilepsia
https://www.readbyqxmd.com/read/28424052/using-implementation-facilitation-to-foster-clinical-practice-quality-and-adherence-to-evidence-in-challenged-settings-a-qualitative-study
#20
Mona J Ritchie, Louise E Parker, Carrie N Edlund, JoAnn E Kirchner
BACKGROUND: We evaluated a facilitation strategy to help clinical sites likely to experience challenges implement evidence-based Primary Care-Mental Health Integration (PC-MHI) care models within the context of a Department of Veterans Affairs (VA) initiative. This article describes our assessment of whether implementation facilitation (IF) can foster development of high quality PC-MHI programs that adhere to evidence, are sustainable and likely to improve clinical practices and outcomes...
April 20, 2017: BMC Health Services Research
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