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https://www.readbyqxmd.com/read/29156709/using-molecular-functional-networks-to-manifest-connections-between-obesity-and-obesity-related-diseases
#1
Jialiang Yang, Jing Qiu, Kejing Wang, Lijuan Zhu, Jingjing Fan, Deyin Zheng, Xiaodi Meng, Jiasheng Yang, Lihong Peng, Yu Fu, Dahan Zhang, Shouneng Peng, Haiyun Huang, Yi Zhang
Obesity is a primary risk factor for many diseases such as certain cancers. In this study, we have developed three algorithms including a random-walk based method OBNet, a shortest-path based method OBsp and a direct-overlap method OBoverlap, to reveal obesity-disease connections at protein-interaction subnetworks corresponding to thousands of biological functions and pathways. Through literature mining, we also curated an obesity-associated disease list, by which we compared the methods. As a result, OBNet outperforms other two methods...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156129/small-molecule-mitochondrial-uncouplers-and-their-therapeutic-potential
#2
Elizabeth S Childress, Stephanie J Alexopoulos, Kyle L Hoehn, Webster L Santos
Small molecule mitohondrial uncouplers transport protons from the mitochondrial inner membrane space into the mitochondrial matrix independent of ATP synthase, uncoupling nutrient metabolism from ATP generation. The therapeutic potential of mitochondrial uncouplers have been investigated for the treatment metabolic diseases such as obesity and type 2 diabetes (T2D), as well as for neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. This perspective will review the mitochondrial uncouplers reported to date and explore their potential as therapeutics...
November 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29156090/a-case-control-study-the-association-of-serum-paraoxonase-1-activity-and-concentration-with-the-development-of-type-2-diabetes-mellitus
#3
J Allen Crow, Edward C Meek, Robert W Wills, Janice E Chambers
BACKGROUND: A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS: Serum samples and clinical data collected and stored at different time points over a 20 year interval in the Air Force Health Study were analyzed. PON1 activity and concentration and C-reactive protein (CRP) concentration in samples from the same individuals 20 years apart were compared using a paired t test (n=159)...
November 20, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29155454/harnessing-the-power-of-regulatory-t-cells-to-control-autoimmune-diabetes-overview-and-perspective
#4
REVIEW
Hua Yu, Ricardo Paiva, Richard A Flavell
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting in islet β-cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Although the mechanisms that initiate T1D still remain elusive, a breakdown of immune tolerance between effector T cells (Teff) and regulatory T cells (Treg) is considered to be the crucial component leading to autoimmunity. As such, strategies have been developed to boost the number and/or function of Treg in the hope of specifically hampering the pathogenic Teff activity...
November 20, 2017: Immunology
https://www.readbyqxmd.com/read/29155440/severe-hypoglycemia-caused-by-lenalidomide
#5
Daniel J Przybylski, Ruemu Birhiray, David J Reeves
Lenalidomide is commonly used for multiple myeloma as either induction or maintenance therapy. The agent is associated with a host of adverse effects, but hypoglycemia has only been reported in one phase I trial in patients with solid tumors. We describe a 74-year-old woman who experienced grade 3 hypoglycemia (blood glucose level 35 mg/dL) likely related to lenalidomide. Her medical history was significant for refractory myeloma and type 2 diabetes mellitus. Lenalidomide was started as maintenance therapy following autologous bone marrow transplantation...
November 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29155328/mitochondrial-trna-leu-uur-c3275t-trna-gln-t4363c-and-trna-lys-a8343g-mutations-may-be-associated-with-pcos-and-metabolic-syndrome
#6
Yu Ding, Bo-Hou Xia, Cai-Juan Zhang, Guang-Chao Zhuo
Polycystic ovary syndrome (PCOS) is a very prevalent endocrine disease affecting reproductive women. Clinically, patients with this disorder are more vulnerable to develop type 2 diabetes mellitus (T2DM), cardiovascular events, as well as metabolic syndrome (MetS). To date, the molecular mechanism underlying PCOS remains largely unknown. Previously, we showed that mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) mutation was an important cause for PCOS. In the current study, we described the clinical and biochemical features of a three-generation pedigree with maternally transmitted MetS, combined with PCOS...
November 16, 2017: Gene
https://www.readbyqxmd.com/read/29155303/therapeutic-vaccine-against-il-1%C3%AE-improved-glucose-control-in-a-mouse-model-of-type-2-diabetes
#7
Yue Zhang, Xiao-Lin Yu, Jun Zha, Li-Zhen Mao, Jia-Qian Chai, Rui-Tian Liu
AIMS: Inflammation is strongly associated with the mechanisms of β-cell failure in type 2 diabetes. Blockade of the key proinflammatory cytokine IL-1β has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1β-targeted therapeutic vaccine consisting of an IL-1β epitope peptide (A1β) and assessed its efficacy on a diabetic KK-A(y) mouse model. MAIN METHODS: KK-A(y) mice were immunized with A1β for three injections at a 2-week interval...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29155153/the-glp-1-response-to-glucose-does-not-mediate-beta-and-alpha-cell-dysfunction-in-hispanics-with-abnormal-glucose-metabolism
#8
Elizabeth Adams, Pauline Genter, Emma Keefe, Kevin Sandow, Virginia Gray, Jerome I Rotter, Yii-Der Ida Chen, Eli Ipp
AIMS: Glucagon-like peptide-1 (GLP-1) contributes to insulin secretion after meals. Though Hispanics have increased risk for type 2 diabetes mellitus, it is unknown if impaired GLP-1 secretion contributes to this risk. We therefore studied plasma GLP-1 secretion and action in Hispanic adults. METHODS: Hispanic (H; n=31) and non-Hispanic (nH; n=15) participants underwent an oral glucose tolerance test (OGTT). All participants were categorized by glucose tolerance into four groups: normal glucose tolerant non-Hispanic (NGT-nH; n = 15), normal glucose tolerant Hispanic (NGT-H; n = 12), impaired glucose tolerant Hispanic (IGT-H; n = 11), or newly diagnosed type 2 diabetes mellitus, Hispanic (T2D-H; n = 8)...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155152/higher-prevalence-and-earlier-appearance-of-geriatric-phenotypes-in-old-adults-with-type-2-diabetes-mellitus
#9
Marina Kotsani, Thekla Chatziadamidou, Dimitrios Economides, Athanase Benetos
AIMS: To compare the prevalence of cognitive dysfunction, depression, lower mobility performance, disability and falls in older community-dwelling individuals with type 2 diabetes mellitus (T2DM) and in controls of similar age. METHODS: We conducted a cross-sectional study in primary health care settings in 3 semi-urban regions in Greece. Were assessed 403 community-dwelling older persons (age ≥65years, median: 73), 198 with and 205 without diabetes. Common geriatric syndromes were studied using structured individual interviews and widely-used screening scales...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155151/hba1c-monitoring-interval-in-patients-on-treatment-for-stable-type-2-diabetes-a-ten-year-retrospective-open-cohort-study
#10
Sachiko Ohde, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Zentaro Yamagata
[Aims] This study aims to suggest an informative interval for HbA1c in DM patients with stable glycemic control, based on test characteristics of the HbA1C assay using the signal-to-noise ratio method. [Methods] This was a retrospective, open cohort study. Data were collected between January 2005 to December 2014 at a tertiary-level community hospital in Japan. All adult patients aged under 75 years, with stable glycemic control on a first pharmaceutical regimen for Type II diabetes, and at least two HbA1c measurements after they achieved glycemic stability, were included in the analysis...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155147/selective-and-membrane-permeable-small-molecule-inhibitors-of-nicotinamide-n-methyltransferase-reverse-high-fat-diet-induced-obesity-in-mice
#11
Harshini Neelakantan, Virginia Vance, Michael D Wetzel, Hua-Yu Leo Wang, Stanton F McHardy, Celeste C Finnerty, Jonathan D Hommel, Stanley J Watowich
There is a critical need for new mechanism-of-action drugs that reduce the burden of obesity and associated chronic metabolic comorbidities. A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis. To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors...
November 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29155124/common-mental-disorders-in-adolescents-with-and-without-type-1-diabetes-reported-occurrence-from-a-countrywide-survey
#12
Gabriela H Telo, Felipe V Cureau, Cláudia S Lopes, Beatriz D Schaan
AIMS: The aim of this study was to evaluate the frequency of common mental disorders symptoms in adolescents with type 1 diabetes in comparison to a population-based sample of adolescents in Brazil. METHODS: We compared characteristics of 116 youth with type 1 diabetes and 73,508 youth without type 1 diabetes from the same population-based sample of adolescents aged 12-17 years, taken from the national Study of Cardiovascular Risk in Adolescents. We evaluated the 12-item General Health Questionnaire (GHQ) score, which is a self-administered screening survey for detecting mental health symptoms...
November 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155123/baseline-factors-associated-with-better-response-to-insulin-lispro-low-mixture-or-insulin-glargine-a-post-hoc-analysis-of-the-durable-study
#13
Nan Jia, Zbigniew Kindracki, Angel Rodriguez
AIMS: To identify baseline characteristics associated with better efficacy and safety responses to twice-daily insulin lispro low mixture (LM) or once-daily insulin glargine (IG) in insulin-naïve patients with type 2 diabetes (T2D). METHODS: This post hoc analysis of the DURABLE study used the gradient-boosting method to generate hypothetical outcomes with the alternative treatment to assigned study drug to evaluate the potential additional benefit of one insulin over the other in association with influential baseline covariates in the same patient...
November 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29155120/risk-of-type-2-diabetes-mellitus-associated-with-plasma-lipid-levels-the-rural-chinese-cohort-study
#14
Ming Zhang, Junmei Zhou, Yu Liu, Xizhuo Sun, Xinping Luo, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Dongsheng Hu
AIM: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. METHODS: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors. RESULTS: 11,929 participants were included in the analysis...
November 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154962/a-novel-type-2-diabetes-mouse-model-of-combined-diabetic-kidney-disease-and-atherosclerosis
#15
Karin E Bornfeldt, Farah Kramer, Anna Batorsky, Jinkuk Choi, Kelly L Hudkins, Peter Tontonoz, Charles E Alpers, Jenny E Kanter
Diabetic kidney disease and atherosclerotic disease are major causes of morbidity and mortality associated with type 2 diabetes (T2D), and diabetic kidney disease is a major cardiovascular risk factor. The BTBR mouse strain with leptin-deficiency (Lep(ob)) has emerged as one of the best models of human diabetic kidney disease. However, no T2D mouse model of combined diabetic kidney disease and atherosclerosis exists. Our goal was to generate such a model. To this end, the LDL receptor was targeted for degradation via IDOL (inducible degrader of the LDL receptor) overexpression, using a liver-targeted adeno-associated virus (AAV-DJ/8) in BTBR wild-type (WT) and BTBR Lep(ob) (OB) mice...
November 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29154936/antidiabetic-and-antiobesity-effects-of-sglt2-inhibitor-ipragliflozin-in-type-2-diabetic-mice-fed-sugar-solution
#16
Atsuo Tahara, Toshiyuki Takasu, Masanori Yokono, Masakazu Imamura, Eiji Kurosaki
Obesity due to excessive calorie intake is a known aggravating factor contributing to the development and progression of type 2 diabetes. Recently, excessive intake of sugar-sweetened beverages has presented challenges in stemming the tide of obesity. Here, we investigated the possible effects of sugar solution intake on the antidiabetic effects of sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin in type 2 diabetic mice that were fed ordinary drinking water, water + glucose solution, or water + sucrose solution...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154913/the-physiological-and-glycaemic-changes-in-breastfeeding-women-with-type-1-diabetes-mellitus
#17
REVIEW
Naomi Achong, Emma L Duncan, H David McIntyre, Leonie Callaway
The World Health Organisation recommends exclusive breastfeeding for the first six months of life ([1]. Breastfeeding confers many short- and long-term benefits for infants and mothers, including reduced childhood obesity and lower maternal body weight [2-6]. Exclusive breastfeeding is also recommended in women with type 1 diabetes mellitus (T1DM), for at least four months [7]. However, the impact of breastfeeding on mothers with T1DM, and, conversely, the impact of maternal T1DM on breastfeeding, is not clear...
November 14, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154713/sex-differences-in-the-psychometric-properties-of-the-pittsburgh-sleep-quality-index
#18
Jonna L Morris, Jeffrey Rohay, Eileen R Chasens
BACKGROUND: The Pittsburgh Sleep Quality Index (PSQI) is a well-known, validated, and reliable instrument used to measure the clinical construct of sleep quality. Little research has been done to measure its psychometric properties by sex. Previous researchers have established the validity of a three-factor structure, but it is unknown whether it applies to both men and women equally. MATERIALS AND METHODS: This study examined 198 participants; women (n = 104), men (n = 94) who were participants in the Diabetes Sleep Treatment Trial, an ongoing study examining the effect of continuous positive airway pressure on glycemic control in people with type 2 diabetes...
November 20, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29154685/a-qualitative-analysis-of-real-time-continuous-glucose-monitoring-data-sharing-with-care-partners-to-share-or-not-to-share
#19
Michelle L Litchman, Nancy A Allen, Vanessa D Colicchio, Sarah E Wawrzynski, Kerri M Sparling, Krissa L Hendricks, Cynthia A Berg
BACKGROUND: Little research exists regarding how real-time continuous glucose monitoring (RT-CGM) data sharing plays a role in the relationship between patients and their care partners. OBJECTIVE: To (1) identify the benefits and challenges related to RT-CGM data sharing from the patient and care partner perspective and (2) to explore the number and type of individuals who share and follow RT-CGM data. METHODS: This qualitative content analysis was conducted by examining publicly available blogs focused on RT-CGM and data sharing...
November 20, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29154506/evaluation-of-major-and-minor-lower-extremity-amputation-in-diabetic-foot-patients
#20
Fırat Ozan, Kaan Gürbüz, İlhami Çelik, Zehra Beştepe Dursun, Erdal Uzun
Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. On clinical evaluation, the type of surgery performed, smoking history, comorbidities, duration of diabetes mellitus (DM) diagnosis, duration of DFU presence, peripheral neuropathy, peripheral arterial disease, results of deep tissue culture, length of hospitalization, and blood parameters were investigated...
August 23, 2017: Turkish Journal of Medical Sciences
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