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JOURNAL ARTICLE
T Lenarz, A Büchner, A Illg
Cochlear implant today are an essential method of auditory rehabilitation in patients with severe to profound hearing loss. Due to the rapid development of implant technology the results have been markedly improved. Today about 80 % of patients can use the telephone and children achieve near to normal hearing and speech development. In consequence, more patients are candidates for a cochlear implant today including those with high frequency deafness and single sided deafness. However, today only 60,000 out of 1 Million CI-candidates in Germany have been implanted so far...
May 2022: Laryngo- Rhino- Otologie
#22
JOURNAL ARTICLE
Xinrui Pang, Miao Ge, Congxia Wang, Jinwei He
The thyroid stimulating hormone (TSH) plays an important regulatory role in maintaining normal function of the thyroid gland. The purpose of this study was to explore the geographical, spatial distribution of TSH normal values in healthy Chinese adults to be used for the formulation of a standard reference. TSH values of 9321 healthy adults from 120 cities in China were collected together with 24 topographic, climatic and soil variables and used for the determination of spatial, significant relationships between TSH and these geographical factors by correlation analysis...
May 6, 2022: Geospatial Health
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JOURNAL ARTICLE
James P Hughes, Brian D Williamson, Chloe Krakauer, Gordon Chau, Brayan Ortiz, Jon Wakefield, Craig Hendrix, K Rivet Amico, Timothy H Holtz, Linda-Gail Bekker, Robert Grant
In trials of oral HIV pre-exposure prophylaxis (PrEP), multiple approaches have been used to measure adherence, including self-report, pill counts, electronic dose monitoring devices, and biological measures such as drug levels in plasma, peripheral blood mononuclear cells, hair, and/or dried blood spots. No one of these measures is ideal and each has strengths and weaknesses. However, accurate estimates of adherence to oral PrEP are important as drug efficacy is closely tied to adherence, and secondary analyses of trial data within identified adherent/non-adherent subgroups may yield important insights into real-world drug effectiveness...
January 25, 2022: Statistics in Medicine
#24
JOURNAL ARTICLE
Shuangyan Liu, Huai Zhang, Haiyan Wang, Juan Huang, Yi Yang, Guoxiang Li, Kuai Yu, Lei Yang
OBJECTIVE: This study aimed to evaluate the efficacy and safety of different stem cell types for spinal cord injury (SCI) therapy and find out the superior treatment for SCI. METHODS: A systematic literature search was performed using PubMed, Embase, the Cochrane Library, Web of Science, VIP, CNKI, and Wan Fang from database initiation to January 30, 2021. A Bayesian network meta-analysis was performed using ADDIS software. The PROSPERO registration number was CRD42020129635...
December 22, 2021: World Neurosurgery
#25
JOURNAL ARTICLE
Zhuang Liu, Rongxun Liu, Yue Zhang, Ran Zhang, Lijuan Liang, Yang Wang, Yange Wei, Rongxin Zhu, Fei Wang
OBJECTIVE: The novel coronavirus disease 2019 (COVID-19) is a global public health emergency that has caused worldwide concern. The mental health of medical students under the COVID-19 epidemic has attracted much attention. This study aims to identify subgroups of medical students based on depression and anxiety and explore the influencing factors during the COVID-19 epidemic in China. METHODS: A total of 29,663 medical students were recruited during the epidemic of COVID-19 in China...
October 12, 2021: BMC Psychiatry
#26
JOURNAL ARTICLE
Chenxi Xu, Fanye Meng, Kwang-Su Park, Aaron J Storey, Weida Gong, Yi-Hsuan Tsai, Elisa Gibson, Stephanie D Byrum, Dongxu Li, Rick D Edmondson, Samuel G Mackintosh, Masoud Vedadi, Ling Cai, Alan J Tackett, H Ümit Kaniskan, Jian Jin, Gang Greg Wang
Nuclear receptor binding SET domain protein 3 (NSD3), a gene located within the 8p11-p12 amplicon frequently detected in human cancers, encodes a chromatin modulator and an attractive onco-target. However, agents that effectively suppress NSD3-mediated oncogenic actions are currently lacking. We report the NSD3-targeting proteolysis targeting chimera (PROTAC), MS9715, which achieves effective and specific targeting of NSD3 and associated cMyc node in tumor cells. MS9715 is designed by linking BI-9321, a NSD3 antagonist, which binds NSD3's PWWP1 domain, with an E3 ligase VHL ligand...
March 17, 2022: Cell Chemical Biology
#27
JOURNAL ARTICLE
Roberto Moretto, Andrew Elliott, Jian Zhang, Hiroyuki Arai, Marco Maria Germani, Veronica Conca, Joanne Xiu, Phillip Stafford, Matthew Oberley, Jim Abraham, David Spetzler, Daniele Rossini, Carlotta Antoniotti, John Marshall, Anthony Shields, Gilberto Lopes, Sara Lonardi, Filippo Pietrantonio, Gianluca Tomasello, Alessandro Passardi, Emiliano Tamburini, Daniele Santini, Giuseppe Aprile, Gianluca Masi, Alfredo Falcone, Heinz-Josef Lenz, Michael Korn, Chiara Cremolini
BACKGROUND: Tumors with homologous recombination deficiency (HRD) show high sensitivity to platinum salts and poly(ADP-ribose) polymerase-inhibitors in several malignancies. In colorectal cancer (CRC), the role of HRD alterations is mostly unknown. METHODS: Next-generation sequencing, whole transcriptome sequencing, and whole exome sequencing were conducted using CRC samples submitted to a commercial Clinical Laboratory Improvement Amendments certified laboratory...
February 7, 2022: Journal of the National Cancer Institute
#28
JOURNAL ARTICLE
Lindsay Ryan
No abstract text is available yet for this article.
June 7, 2021: JAMA
#29
JOURNAL ARTICLE
Ambarish M Athavale, Peter D Hart, Mathew Itteera, David Cimbaluk, Tushar Patel, Anas Alabkaa, Jose Arruda, Ashok Singh, Avi Rosenberg, Hemant Kulkarni
Importance: Interstitial fibrosis and tubular atrophy (IFTA) is a strong indicator of decline in kidney function and is measured using histopathological assessment of kidney biopsy core. At present, a noninvasive test to assess IFTA is not available. Objective: To develop and validate a deep learning (DL) algorithm to quantify IFTA from kidney ultrasonography images. Design, Setting, and Participants: This was a single-center diagnostic study of consecutive patients who underwent native kidney biopsy at John H...
May 3, 2021: JAMA Network Open
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JOURNAL ARTICLE
Hiroyuki Arai, Andrew Elliott, Joanne Xiu, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Davendra Sohal, Richard M Goldberg, Michael J Hall, Aaron J Scott, Moh'd Khushman, Jimmy J Hwang, Emil Lou, Benjamin A Weinberg, John L Marshall, Albert C Lockhart, Phillip Stafford, Jian Zhang, Roberto Moretto, Chiara Cremolini, W Michael Korn, Heinz-Josef Lenz
PURPOSE: Defective DNA damage response (DDR) is a hallmark of cancer leading to genomic instability and is associated with chemosensitivity. While the mismatch repair system has been extensively studied, the clinical implications of other mechanisms associated with DDR alterations in patients with colorectal cancer (CRC) remain unclear. This study aimed to understand DDR pathways' alterations and their association with common clinical features in CRC patients. EXPERIMENTAL DESIGN: Next-generation sequencing and whole transcriptome sequencing were conducted using formalin-fixed paraffin-embedded samples submitted to a commercial CLIA-certified laboratory...
March 25, 2021: Clinical Cancer Research
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JOURNAL ARTICLE
Tasneem Lokhandwala, Binglin Yue, Anna D Coutinho, Christopher F Bell
OBJECTIVE: The management of systemic lupus erythematosus (SLE) flares can incur substantial healthcare costs. In the phase III BLISS-SC trial, subcutaneous (SC) belimumab 200 mg plus standard therapy was associated with significant reductions in time to severe flare, and risk of flares, versus placebo plus standard therapy, in adults with active SLE. We evaluated whether the reduction in SLE flares with belimumab SC plus standard therapy translated to lower healthcare costs. METHODS: A retrospective, post hoc economic analysis of BLISS-SC data was conducted...
February 2021: Lupus Science & Medicine
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JOURNAL ARTICLE
Hao-Yuan Li, Zhu-Hong You, Lei Wang, Xin Yan, Zheng-Wei Li
It is reported that microRNAs (miRNAs) play an important role in various human diseases. However, the mechanisms of miRNA in these diseases have not been fully understood. Therefore, detecting potential miRNA-disease associations has far-reaching significance for pathological development and the diagnosis and treatment of complex diseases. In this study, we propose a novel diffusion-based computational method DF-MDA for predicting miRNA-disease association based on the assumption that molecules are related to each other in human physiological processes...
January 8, 2021: Molecular Therapy
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JOURNAL ARTICLE
Michaela Brzáková, Jindřich Čítek, Alena Svitáková, Zdeňka Veselá, Luboš Vostrý
The objective of this study was to estimate genetic parameters for age at first calving (AFC) and first calving interval (FCI) for the entire beef cattle population and separately for the Charolais (CH) and Aberdeen Angus (AA) breeds in the Czech Republic. The database of performance testing between the years 1991 and 2019 was used. The total number of cows was 83,788 from 11 breeds. After editing, the data set contained 33,533 cows, including 9321 and 4419 CH and AA cows, respectively. The relationship matrix included 85,842 animals for the entire beef population and 24,248 and 11,406 animals for the CH and AA breeds, respectively...
November 16, 2020: Animals: An Open Access Journal From MDPI
#34
JOURNAL ARTICLE
Venoarterial extracorporeal membrane oxygenation is a viable option as a bridge to heart transplant.
Kristen T Carter, Robert O'Brien, Sharon B Larson, Lawrence L Creswell, Matthew Kutcher, David A Baran, Jack G Copeland, Hannah Copeland
OBJECTIVE: Venoarterial extracorporeal membrane oxygenation is a rescue therapy for patients in cardiogenic shock. We hypothesize that patients bridged to heart transplant with extracorporeal membrane oxygenation have decreased survival. METHODS: The United Network of Organ Sharing database was retrospectively reviewed from January 1, 1999, to March 31, 2018, for heart transplant recipients. Recipients bridged with any form of mechanical support and those without support were compared with recipients bridged with extracorporeal membrane oxygenation...
August 16, 2020: Journal of Thoracic and Cardiovascular Surgery
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JOURNAL ARTICLE
Jing Yue, Ronghao Zheng, Huiping Wei, Jie Li, Jiannan Wu, Ping Wang, Hui Zhao
BACKGROUND: A considerable debate on whether fluid bolus could decrease childhood mortality in pediatric patients with septic or severe infection shock is still unresolved. A systematic review and meta-analysis was conducted to investigate the mortality rates after fluid bolus among children with septic or severe infection shock. METHODS: A systematic electronic search of PubMed, MEDLINE, Cochrane Library, and EMBASE databases was conducted to identify relevant published studies till March 30, 2020...
August 1, 2021: Shock
#36
JOURNAL ARTICLE
R Lelešius, P Girdauskaitė, A Karpovaitė, R Mickienė, T Drevinskas, N Tiso, O Ragažinskienė, L Kubilienė, A Maruška, A Šalomskas
Herpesviruses (HV) are pathogens causing infections in humans and animals worldwide. Since it shares many common features with other HV, bovine HV type 1 (BoHV-1) was selected as a model to test the anti-herpesviral activity of medicinal plants.Fifteen plants were chosen in this study for their medical, antibacterial and antiviral proper-ties. The aim was to investigate ethanolic extracts from the selected medicinal plants for anti-BoHV-1 activity. The virucidal activities were evaluated by comparing the effect of noncy-totoxic concentrations of extracts on BoHV-1 strain 1640 replication in Madin-Darby bovine kidney (MDBK) cells...
June 2020: Polish Journal of Veterinary Sciences
#37
JOURNAL ARTICLE
Arthur Shiyovich, Nir Shlomo, Tal Cohen, Zaza Iakobishvili, Ran Kornowski, Alon Eisen
INTRODUCTION: Multi-vessel coronary artery disease (MV-CAD) is common among patients with acute coronary syndrome (ACS) and is associated with worse outcomes. OBJECTIVES: To examine temporal trends of patients presenting with ACS and MV-CAD. METHODS: Time-dependent analysis of patients enrolled in the ACS Israeli Surveys (ACSIS) between 2004-2016 by 3 time periods: early (2004-2006; n = 2111), mid (2008-2010; n = 2049), and late (2013-2016; n = 2010)...
January 21, 2020: International Journal of Cardiology
#38
REVIEW
A J Scheen
AIMS: This study compared the reduction of glycated haemoglobin (HbA1c) with sodium-glucose cotransporter type-2 inhibitors (SGLT2is) vs. dipeptidyl peptidase-4 inhibitors (DPP-4is) as add-ons to metformin in patients with type 2 diabetes mellitus (T2DM), with a specific focus on HbA1c changes according to baseline HbA1c. MATERIALS AND METHODS: Electronic databases were scrutinized for randomized controlled trials (RCTs) evaluating the reduction of HbA1c from baseline (Δ HbA1c) with an SGLT2i or DPP-4i in patients with T2DM not well controlled by metformin monotherapy...
June 2020: Diabetes & Metabolism
#39
JOURNAL ARTICLE
Guobo Xie, Zhiliang Fan, Yuping Sun, Cuiming Wu, Lei Ma
BACKGROUND: Recently, numerous biological experiments have indicated that microRNAs (miRNAs) play critical roles in exploring the pathogenesis of various human diseases. Since traditional experimental methods for miRNA-disease associations detection are costly and time-consuming, it becomes urgent to design efficient and robust computational techniques for identifying undiscovered interactions. METHODS: In this paper, we proposed a computation framework named weighted bipartite network projection for miRNA-disease association prediction (WBNPMD)...
September 23, 2019: Journal of Translational Medicine
#40
JOURNAL ARTICLE
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Mark Petronczki, Markus Zeeb, Nikolai Mischerikow, Abdellah Allali-Hassani, Magdalena M Szewczyk, Fengling Li, Steven Kennedy, Masoud Vedadi, Dalia Barsyte-Lovejoy, Peter J Brown, Kilian V M Huber, Catherine M Rogers, Carrow I Wells, Oleg Fedorov, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Heribert Arnhof, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Maja Corcokovic, Bernadette Sharps, Sandra Winkler, Daniela Häring, Xiao-Ling Cockcroft, Julian E Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Thomas Gerstberger, Guido Boehmelt, Christopher R Vakoc, Cheryl H Arrowsmith, Mark Pearson, Darryl B McConnell
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in breast and squamous lung cancer. Recently, it was demonstrated that the PWWP1 domain of NSD3 is required for the viability of acute myeloid leukemia cells. To further elucidate the relevance of NSD3 in cancer biology, we developed a chemical probe, BI-9321, targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 µM...
July 8, 2019: Nature Chemical Biology
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