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A Montaner Ramón, Z Galve Pradel, C Fernández Espuelas, L Jiménez Montañés, M P Samper Villagrasa, S Rite Gracia
INTRODUCTION: Patent ductus arteriosus (PDA) is a prevalent condition in preterm infants, and may be related to increased morbidity and mortality in the most immature newborns. Recent studies have examined the usefulness of brain natriuretic propeptide (proBNP) in the diagnosis of this pathology. The aim of the study was to evaluate the diagnostic efficacy of proBNP as a marker of hemodynamic overload in PDA. PAIENTS AND METHODS: A retrospective study was conducted on preterm infants less than 32 weeks of gestation and/or weight less than 1500 grams...
February 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
A C Achhra, A Mocroft, P Reiss, C Sabin, L Ryom, S de Wit, C J Smith, A d'Arminio Monforte, A Phillips, R Weber, J Lundgren, M G Law
OBJECTIVES: The aim of the study was to assess the impact of the gain in body mass index (BMI) observed immediately after antiretroviral therapy (ART) initiation on the subsequent risk of cardiovascular disease (CVD) and diabetes. METHODS: We analysed data from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) cohort study. Outcomes were development of (i) CVD (composite of myocardial infarction/stroke/coronary procedure) and (ii) diabetes. The main exposure variable was change in BMI from ART initiation (pre-ART) to 1 year after initiation (continuous variable) in treatment-naïve individuals initiating ART with no history of CVD or diabetes (for respective outcomes)...
April 2016: HIV Medicine
Tiana A Garrett, John Davies-Cole, Bruce Furness
BACKGROUND: In the District of Columbia (DC), Neisseria gonorrhoeae (gonorrhea) infections accounted for more than 25% of 9321 incident sexually transmitted infections reported in 2011; untreated infections can lead to reproductive complications and a higher risk for HIV transmission. In DC, limited capacity to measure the prevalence of antibiotic-resistant N. gonorrhoeae is available; culture-based antibiotic susceptibility testing (AST) is needed to monitor antimicrobial resistance...
August 2015: Sexually Transmitted Diseases
Y H Lee, G G Song
AIMS: This study aimed to assess the relative efficacy and safety of tacrolimus, mycophenolate mofetil (MMF) and cyclophosphamide (CYC) as induction therapy for lupus nephritis. METHODS: Randomized controlled trials (RCTs) examining the efficacy and safety of tacrolimus, MMF and CYC for induction therapy in patients with lupus nephritis were included. We performed a Bayesian random-effects network meta-analysis to combine direct and indirect evidence from the RCTs...
December 2015: Lupus
Eitan Auriel, M Brandon Westover, Matt T Bianchi, Yael Reijmer, Sergi Martinez-Ramirez, Jun Ni, Ellis Van Etten, Matthew P Frosch, Panagiotis Fotiadis, Kris Schwab, Anastasia Vashkevich, Grégoire Boulouis, Alayna P Younger, Keith A Johnson, Reisa A Sperling, Trey Hedden, M Edip Gurol, Anand Viswanathan, Steven M Greenberg
BACKGROUND AND PURPOSE: Cerebral microinfarcts (CMI) are important contributors to vascular cognitive impairment. Magnetic resonance imaging diffusion-weighted imaging (DWI) hyperintensities have been suggested to represent acute CMI. We aim to describe a mathematical method for estimating total number of CMI based on the presence of incidental DWI lesions. METHODS: We reviewed magnetic resonance imaging scans of subjects with cognitive decline, cognitively normal subjects and previously reported subjects with past intracerebral hemorrhage (ICH)...
August 2015: Stroke; a Journal of Cerebral Circulation
Amanda M Norton, Leah N McKenzie, Peter R Brooks, Linda J Pappalardo
The nonperoxide antibacterial activity of New Zealand ma̅nuka honey originates from dihydroxyacetone (DHA) within Leptospermum scoparium nectar. This study determined if DHA was present within the nectar of four Australian Leptospermum species: L. laevigatum, L. polygalifolium, L. trinervium, and L. whitei. A rapid and convenient new method was developed, which quantitated DHA/sugar ratios (ppm). The DHA and sugars were derivatized with o-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine hydrochloride and analyzed via RP-HPLC with diode array detection at two wavelengths (200 and 243 nm)...
July 29, 2015: Journal of Agricultural and Food Chemistry
Dan M Shane, Padmaja Ayyagari
OBJECTIVES: We used data from the Medical Expenditure Panel Survey to assess the impact of the Affordable Care Act's dependent coverage mandate on disparities in health insurance coverage rates and evaluated whether non-Hispanic blacks and Hispanics gained coverage at the same rates as non-Hispanic whites. METHODS: To estimate changes in insurance rates, we employed a difference-in-difference regression approach comparing 7962 young adults aged 19-25 to 9321 adults aged 27-34...
June 2014: Medical Care
Tomohiro Sakashita, Ryuichi Hayashi, Akihiro Homma, Kazuto Matsuura, Kengo Kato, Kazuyoshi Kawabata, Nobuya Monden, Yasuhisa Hasegawa, Tetsuro Onitsuka, Yasushi Fujimoto, Shigemichi Iwae, Kenji Okami, Takashi Matsuzuka, Kunitoshi Yoshino, Masato Fujii
BACKGROUND: The purpose of this retrospective analysis was to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion. METHODS: Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality. RESULTS: The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy, and radiotherapy (RADPLAT), intravenous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively...
April 2015: Head & Neck
Waraporn Putalun, Gorawit Yusakul, Paritad Saensom, Boonchoo Sritularak, Hiroyuki Tanaka
Polyclonal antibody against iriflophenone 3-C-β-d-glucoside (IP3G), a major compound from the leaves of Aquilaria spp., was produced for the development of an enzyme-linked immunosorbent assay (ELISA). The results showed that the antibodies were specific for IP3G. The produced antibody has low cross reactivity with iriflophenone 3,5-C-β-d-diglucopyranoside (13%), genkwanin 5-O-β-primeveroside (3.55%) and no cross reactivity found in other compounds. The range of ELISA assay extends from 100 to 1560 ng/mL with coefficient of variation (CV) 1...
September 2013: Journal of Food Science
Wenjing Sang, Yalei Zhang, Xuefei Zhou, T C Zhang
As one kind of emerging contaminant, synthetic musks (SMs) are commonly used in varying amounts in many personal care products and have been detected in different environmental systems. Occurrence and fate of four common SMs [galaxolide (HHCB), tonalide (AHTN), musk xylene (MX) and musk ketone (MK)] were studied in different sewage treatment plants (STPs) of Shanghai, China among different seasons. Results showed that total dissolved concentrations of the four SMs were 536-3,173 ng/L in influent, 351-2,595 ng/L in effluent and 147-6,839 μg/kg dry weights in sludge...
2012: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Samantha Bromfield, John Keenan, Pauline Jolly, Gerald McGwin
OBJECTIVE: To explore the relationship between age-related macular degeneration (AMD) and hypothyroidism in a population-based sample of adults 50 years and older in the United States. STUDY POPULATION: Participants aged 50 years and older (N = 9,677). Of this total, 356 participants reported having AMD and 9321 reported not having AMD. METHODS: Information pertaining to self-reported thyroid disease (specifically hypothyroidism) and AMD was obtained from the 2008 National Health Interview Survey...
June 2012: Current Eye Research
Laura D Howe, Alicia Matijasevich, Kate Tilling, Marie-Jo Brion, Sam D Leary, George Davey Smith, Debbie A Lawlor
BACKGROUND: Maternal smoking during pregnancy is associated with reduced offspring birth length and has been postulated as a risk factor for obesity. Causality for obesity is not established. Causality is well-supported for birth length, but evidence on persistence of height deficits is inconsistent. METHODS: We examined the association between maternal smoking during pregnancy and trajectories of offspring height (0-10 years, N = 9424), ponderal index (PI) (0-2 years, N = 9321) and body mass index (BMI) (2-10 years, N = 8887) in the Avon Longitudinal Study of Parents and Children...
June 2012: International Journal of Epidemiology
Ying Ge, Xiao-Qing Liu, Ying-Chun Xu, Shan Xu, Min-Hong Yu, Wei Zhang, Guo-Hua Deng
BACKGROUND: Blood culture contamination is a significant adverse event. The aim of this project was to evaluate the efficacy of a strict blood collection procedure in reducing the blood culture contamination rate. METHODS: A prospectively controlled study was performed in two different medical areas in Peking Union Medical College Hospital (PUMCH) for 16 months (from May 2006 to September 2007). In test group, a strict blood collection procedure was carried out by trained nurses with the veinpuncture sites were scrupulously disinfected with 2...
December 2011: Chinese Medical Journal
Martin M Meremikwu, Sarah Donegan, David Sinclair, Ekpereonne Esu, Chioma Oringanje
BACKGROUND: In malaria endemic areas, pre-school children are at high risk of severe and repeated malaria illness. One possible public health strategy, known as Intermittent Preventive Treatment in children (IPTc), is to treat all children for malaria at regular intervals during the transmission season, regardless of whether they are infected or not. OBJECTIVES: To evaluate the effects of IPTc to prevent malaria in preschool children living in endemic areas with seasonal malaria transmission...
2012: Cochrane Database of Systematic Reviews
Jun-Sheng Yang, Chuan-Lu Yang, Mei-Shan Wang, Bao-Dong Chen, Xiao-Guang Ma
Information on the interfacial interaction is vital in understanding the crystallization of short polymer chains around oriented nuclei. However, this interaction is difficult to observe at the atomic level. Molecular dynamics simulations are performed to investigate the structural formation of polymer chains induced by the highly oriented slab or the stretched bundle of polymer chains. The results show that the surface-induced crystallization of polymer chains is greatly influenced by the foreign surface on the crystal structure and the morphology of the polymers, hence providing molecular-level support for previous experimental observations [Lotz et al...
February 23, 2012: Journal of Physical Chemistry. B
Manu Sharma, Demetrius M Maraganore, John P A Ioannidis, Olaf Riess, Jan O Aasly, Grazia Annesi, Nadine Abahuni, Anna Rita Bentivoglio, Alexis Brice, Christine Van Broeckhoven, Marie-Christine Chartier-Harlin, Alain Destée, Ana Djarmati, Alexis Elbaz, Matthew Farrer, Carlo Ferrarese, J Mark Gibson, Suzana Gispert, Nobutaka Hattori, Barbara Jasinska-Myga, Christine Klein, Suzanne Lesage, Timothy Lynch, Peter Lichtner, Jean-Charles Lambert, Anthony E Lang, George D Mellick, Francesa De Nigris, Grzegorz Opala, Aldo Quattrone, Chiara Riva, Ekaterina Rogaeva, Owen A Ross, Wataru Satake, Peter A Silburn, Jessie Theuns, Tatsushi Toda, Hiroyuki Tomiyama, Ryan J Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Thomas Gasser, Rejko Krüger
Sepiapterin reductase (SPR) gene is an enzyme which catalyses the final step of tetrahydrobiopterin synthesis (BH4) and was implicated in Parkinson's disease (PD) pathogenesis as a candidate gene for PARK3 locus. A number of studies yielded association of the PARK3 locus with PD, and SPR knockout mice were shown to display parkinsonian features. To evaluate the role of SPR gene polymorphisms in diverse populations in PD, we performed collaborative analyses in the Genetic Epidemiology of Parkinson Disease (GEO-PD) Consortium...
November 2011: Neurobiology of Aging
Khadijeh Kalateh, Ali Norouzi, Amin Ebadi, Roya Ahmadi, Vahid Amani
In the mol-ecule of the title compound, [HgBr(2)(C(10)H(9)N(3))], the Hg(II) atom is four-coordinated in a distorted tetra-hedral configuration by two N atoms from the chelating di-2-pyridylamine ligand and by two Br atoms. In the crystal structure, inter-molecular N-H⋯Br hydrogen bonds link the mol-ecules into centrosymmetric dimers. There are π-π contacts between the pyridine rings [centroid-centroid distances = 3.9662 (5) and 3.9321 (4) Å]. There also exists a C-H⋯π contact between the pyridine CH group and a pyridine ring...
2008: Acta Crystallographica. Section E, Structure Reports Online
H H Farah, I A Ghandour
OBJECTIVES: To investigate the oral hygiene practice, the prevalence of dental plaque, gingivitis and calculus among 12-year-old Sudanese schoolchildren in Khartoum province, and to correlate the above to gender and educational level of parents. METHODS: A total of 636 children 12 years of age, whose parents granted permission, were examined from public and private schools in different geographical locations representing different socioeconomic classes in Khartoum province...
September 2009: Odonto-stomatologie Tropicale, Tropical Dental Journal
Byeong Hwa Yun, Peter C Dedon, Nicholas E Geacintov, Vladimir Shafirovich
The photosensitized hole injection and guanine base damage phenomena have been investigated in the DNA sequence, 5'-d(CATG(1)(Py)CG(2)TCCTAC) with a site-specifically positioned pyrene-like (Py) benzo[a]pyrene 7,8-diol 9,10-epoxide-derived N(2)-guanine adduct (G(1)(Py)). Generation of the Py radical cation and subsequent hole injection into the DNA strand by a 355 nm nanosecond laser pulses (approximately 4 mJ cm(-2)) results in the transformation of G(1)(Py) to the imidazolone derivative Iz(1)(Py) and a novel G(1)(Py*) photoproduct that has a mass larger by 16 Da (M+16) than the mass (M) of G(1)(Py)...
May 2010: Photochemistry and Photobiology
D Kernick, S Stapley, J Campbell, W Hamilton
The aim was to describe the consulting behaviour and clinical outcomes of children presenting with headache in primary care. This was a historical cohort study using data from the UK General Practitioner Research Database. Cases were children aged 5-17 years who presented to primary care with primary headache (migraine, tension-type headache, cluster headache) or undifferentiated headache (no further descriptor). Controls were age, sex and practice matched. Their records were examined for consultations, referrals, relevant treatments and specific diseases in the subsequent year...
December 2009: Cephalalgia: An International Journal of Headache
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