keyword
https://read.qxmd.com/read/38546531/characterization-of-the-neurochemical-and-behavioral-effects-of-the-phenethylamine-2-cl-4-5-mdma-in-adolescent-and-adult-male-rats
#21
JOURNAL ARTICLE
Gessica Piras, Cristina Cadoni, Francesca Caria, Nicholas Pintori, Enrica Spano, Maksims Vanejevs, Anastasija Ture, Graziella Tocco, Nicola Simola, Maria Antonietta De Luca
BACKGROUND: The proliferation of Novel Psychoactive Substances (NPS) in the drug market raises concerns about uncertainty on their pharmacological profile and the health hazard linked to their use. Within the category of synthetic stimulant NPS, the phenethylamine 2-Cl-4,5-methylenedioxymethamphetamine (2-Cl-4,5-MDMA) has been linked to severe intoxication requiring hospitalization. Thereby, the characterization of its pharmacological profile is urgently warranted. METHODS: By in vivo brain microdialysis in adolescent and adult male rats we investigated the effects of 2-Cl-4,5-MDMA on dopamine (DA) and serotonin (5-HT) neurotransmission in two brain areas critical for the motivational and reinforcing properties of drugs, the nucleus accumbens (NAc) shell and the medial prefrontal cortex (mPFC)...
March 28, 2024: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/38545674/effectiveness-of-hydrogen-peroxide-wipes-for-surface-disinfection-in-healthcare-facilities
#22
JOURNAL ARTICLE
Marco Lopuzzo, Maria Teresa Montagna, Francesco Triggiano, Giuseppina Caggiano
INTRODUCTION: The correct method of surface disinfection in hospitals is an essential tool in the fight against the spread of healthcareassociated infections caused by multi-resistant microorganisms. Currently, there are many disinfectants on the market that can be used against different microorganisms. However, the effectiveness of different active molecules is controversial in the literature. STUDY DESIGN: The aim of this study was to evaluate the effectiveness of wipes based on hydrogen peroxide (1...
March 21, 2024: Annali di Igiene: Medicina Preventiva e di Comunità
https://read.qxmd.com/read/38545166/continuous-monitoring-of-body-temperature-for-objective-detection-of-health-and-safety-risks-in-construction-sites-an-analysis-of-the-accuracy-and-comfort-of-off-the-shelf-wearable-sensors
#23
JOURNAL ARTICLE
Farnad Nasirzadeh, Chandan Karmakar, Ahsan Habib, Kevin Benny Neelangal, Mostafa Mir, SangHyun Lee, Tony Arnel
Recent studies have shown the potential of wearable sensors for objective detection of health and safety risks in construction workers through their collected physiological data. Body temperature, as the focus of the current study, is one of the most important physiological parameters that can help to detect various health and safety risks such as heat stress, physical fatigue, and infectious diseases. This study aims to assess the applicability and performance of off-the-shelf wearable sensor devices to monitor workers' body temperature in construction sites by evaluating the accuracy of temperature measurements as well as the comfort of the devices...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38541347/implementing-aging-in-place-in-hong-kong-meeting-the-needs-and-aspirations-of-older-adults-and-their-caregivers-living-in-private-housing
#24
JOURNAL ARTICLE
Jean Woo, Keilee Mok, Wui-Ling Chu, Regina Lo, Rina Ko
A policy of aging in place should be accompanied by physical and social environments that support healthy aging. This article describes how a property development company in Hong Kong sought to elicit the views of older people and their caregivers towards elderly services through a market research company, using questionnaire surveys followed by focus groups. Over 80% of all participants rated healthy dietary habits and exercise, maintaining mental and spiritual health, and maintaining a generally healthy lifestyle as important...
March 14, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541324/from-acute-infection-to-prolonged-health-consequences-understanding-health-disparities-and-economic-implications-in-long-covid-worldwide
#25
REVIEW
Jaleel Jerry G Sweis, Fatima Alnaimat, Valeria Esparza, Supritha Prasad, Abeera Azam, Zeel Modi, Mina Al-Awqati, Pim Jetanalin, Nadia J Sweis, Christian Ascoli, Richard M Novak, Israel Rubinstein, Ilias C Papanikolaou, Nadera Sweiss
The COVID-19 pandemic has resulted in a growing number of patients experiencing persistent symptoms and physiological changes after recovering from acute SARS-CoV-2 infection, known as Long COVID. Long COVID is characterized by recurring symptoms and inflammation across multiple organ systems. Diagnosis can be challenging, influenced by factors like demographics, comorbidities, and immune responses. Long COVID impacts various organ systems and can have neuropsychological effects. Health disparities, particularly related to race, contribute to a higher burden of infection and ongoing symptoms in minority populations...
March 11, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38537295/poor-policy-and-inadequate-regulation-of-medical-technology-is-driving-low-value-care-in-australia-s-private-health-system
#26
JOURNAL ARTICLE
Rachel David
Millions of Australians use the private health system every year. They should receive safe, high-quality, value-based care. However, poor policy and inadequate regulation of medical technology is driving low-value care at great expense to consumers and the broader health system. Key drivers include the Prescribed List of Medical Devices and Human Tissue, gaps in quality and safety controls for devices being used, and marketing and conflicts of interest. All of these should be addressed to reduce low-value care in Australia's private health system, so consumers are protected from harm and limited health budgets are used effectively...
March 28, 2024: Australian Health Review: a Publication of the Australian Hospital Association
https://read.qxmd.com/read/38536616/effectiveness-of-ixekizumab-in-chinese-patients-with-moderate-severe-plaque-psoriasis-with-special-area-involvement-subanalysis-of-a-prospective-multicenter-observational-real-world-study
#27
JOURNAL ARTICLE
Ying Li, Chengzhi Lv, Lin Dang, Bingjiang Lin, Juan Tao, Chunlei Zhang, Xiaoyong Zhou, Han Ma, Yi Lu, Rong Chen, Jinnan Li, Guanshen Dou, Yunsheng Liang, Yanhua Liang, Yuling Shi
INTRODUCTION: Ixekizumab, a monoclonal antibody against interleukin-17A, demonstrated effectiveness in the treatment of psoriasis in a Chinese real-world study that was consistent with previous randomized controlled trials. Here, we report further analyses from this study to explore the effectiveness of ixekizumab for treating patients with psoriasis and the involvement of special body areas (scalp, nail, joint, palmoplantar, or genital areas). METHODS: A multicenter, prospective, observational, single-arm, post-marketing surveillance study was conducted in patients aged ≥ 18 years with moderate-to-severe plaque psoriasis and prescribed with ixekizumab in 26 Chinese hospitals...
March 27, 2024: Dermatology and Therapy
https://read.qxmd.com/read/38529260/navigating-the-new-eu-medical-devices-regulation-retrospective-post-market-follow-up-of-hyaluronic-acid-injections-for-knee-osteoarthritis
#28
JOURNAL ARTICLE
Alejandro Alcina Navarro, Sara Gómez Valero, Mercedes Gimeno Del Sol, María Pilar Coronel Granado
PURPOSE: The entry into force of the new Medical Device Regulation (EU) 2017/745 highlights the need for post-market clinical follow-up to ensure the safety and efficacy throughout the life cycle of medical devices. This study evaluates the efficacy and safety of a single intra-articular hyaluronic acid injection in knee osteoarthritis in real-world conditions, over a six-month period, aligning with the summary of safety and clinical performance (SSCP) required by the new regulation. PATIENTS AND METHODS: Patients over 18 years of age with knee osteoarthritis, treated with a single injection of HA (Adant® One, Meiji Pharma Spain, Spain) at a 3rd level hospital...
2024: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/38527076/parenteral-nutrition-at-home-long-term-parenteral-nutrition
#29
JOURNAL ARTICLE
Vanessa J Kumpf, Brenda Gray, Jessica Monczka, Sarah Zeraschi, Stanislaw Klek
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Some diseases require that patients receive parenteral nutrition (PN) over a prolonged time period...
March 25, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38521883/real-world-effectiveness-of-high-dose-tafamidis-on-neurologic-disease-progression-in-mixed-phenotype-variant-transthyretin-amyloid-cardiomyopathy
#30
JOURNAL ARTICLE
Nicholas Streicher, Leslie Amass, Rong Wang, Jennifer M Stephens, Traci LeMasters, Rutika Raina, Emma Merrill, Farooq H Sheikh
INTRODUCTION: Transthyretin amyloidosis (ATTR) is a progressive, heterogeneous rare disease manifesting as ATTR polyneuropathy (ATTR-PN), ATTR cardiomyopathy (ATTR-CM), or a mixed phenotype. Tafamidis meglumine (20 mg po qd) is approved in some markets to delay neurologic progression in ATTR-PN, while high-dose tafamidis (80/61 mg po qd) is approved worldwide to reduce cardiovascular mortality and cardiovascular-related hospitalization in ATTR-CM. The objective of this study was to assess the real-world benefit of high-dose tafamidis for delaying neurologic progression in patients with mixed-phenotype variant ATTR-CM (ATTRv-CM)...
March 23, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38520199/dimetindene-is-the-minimum-toxic-dose-for-children-too-strict
#31
JOURNAL ARTICLE
Michal Čečrle, Daniela Pelclová, Navrátil Tomáš, Sergej Zacharov
Dimetindene is a sedating antihistamine indicated for the symptomatic treatment of allergic conditions. Dimetindene is marketed among others under the trade name Fenistil (oral solution). Toxicity data are limited, and there is no consensus on the dose at which children require hospitalization. Objective is to determine the potentially toxic dose in children. Data in children with age up to 15 years were obtained from hospital discharge reports. Of 139 paediatric hospital discharge reports, 23 cases (16...
March 23, 2024: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/38512638/analyzing-the-20-year-declining-trend-of-hospital-length-of-stay-in-european-countries-with-different-healthcare-systems-and-reimbursement-models
#32
JOURNAL ARTICLE
Davide Golinelli, Francesco Sanmarchi, Fabrizio Toscano, Andrea Bucci, Nicola Nante
The study aims to investigate the last 20-year (2000-2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat and Global Burden of Disease study databases, with dependent and control variables aggregated at the national level over a period of 20 years. A time trend analysis was conducted using a weighted least squares model for panel data to investigate the association between LOS, HS models [National Health Service (NHS), National Health Insurance, Social Health Insurance (SHI), and Etatist Social Health Insurance], healthcare reimbursement schemes [Prospective Global Budget (PGB), Diagnosis Related Groups (DRG), and Procedure Service Payment (PSP)], and control variables...
March 21, 2024: International Journal of Health Economics and Management
https://read.qxmd.com/read/38508341/shock-and-temperature-monitoring-during-transport-of-immunoglobulins-from-a-hospital-to-patients-homes-a-pilot-study
#33
JOURNAL ARTICLE
M Merve Susam, Charlotte Sikking, Lisa Hardebol, Marlou Florack, Mirjam Crul
Transport of biopharmaceuticals from a hospital to a patient's home is scarcely researched but it is essential to investigate the effects of such transport on the stability of the drug, before home-based care can take place. In this study, transport of biopharmaceuticals in vials that are marketed as ready-to-administer from a hospital pharmacy to patients' homes was investigated. Immunoglobulin packages were tracked with 10G and 25G shock indicators and temperature data loggers. In the control group, immunoglobulins were transported from the hospital pharmacy to the outpatient daycare unit...
March 18, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38505934/variation-and-drivers-of-costs-for-emergency-department-visits-among-children-in-8-states
#34
JOURNAL ARTICLE
Eli C Freiman, Michael C Monuteaux, Kenneth A Michelson
OBJECTIVE: To describe variation in costs for emergency department (ED) visits among children and to assess hospital and regional factors associated with costs. METHODS: Cross-sectional study of all ED encounters among children under 18 years in 8 states from 2014 to 2018. The primary outcome was each hospital's mean inflation-adjusted ED costs. We evaluated variability in costs between hospitals and determined factors associated with costs using hierarchical linear models at the state, region, and hospital levels...
March 20, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38500193/linking-undergraduates-future-work-self-and-employability-a-moderated-mediation-model
#35
JOURNAL ARTICLE
Yaju Ma, Lingyan Hou, Wenjing Cai, Xiaopei Gao, Lin Jiang
BACKGROUND: The career intentions of students play a crucial role in shaping the growth of the hospitality and tourism industry. Previous research underlines the significance of future work self in predicting outcomes related to one's career. However, there is limited knowledge regarding the precise ways, timing, and conditions under which the future work self of undergraduate students can enhance their employability. METHODS: This paper aims to address the existing research gap by employing career construction theory and self-determination theory to propose a moderated mediation model-i...
March 18, 2024: BMC Psychology
https://read.qxmd.com/read/38489122/strategic-behaviour-and-decision-making-in-competitive-hospital-markets-an-experimental-investigation
#36
JOURNAL ARTICLE
Johann Han, Nadja Kairies-Schwarz, Markus Vomhof
We investigate quality provision and the occurrence of strategic behaviour in competitive hospital markets where providers are assumed to be semi-altruistic towards patients. For this, we employ a laboratory experiment with a hospital market framing. Subjects decide on the quality levels for one of three competing hospitals respectively. We vary the organizational aspect of whether quality decisions within hospitals are made by individuals or teams. Realized monetary patient benefits go to real patients outside the lab...
March 15, 2024: International Journal of Health Economics and Management
https://read.qxmd.com/read/38488778/accountable-care-organization-leader-perspectives-on-the-medicare-shared-savings-program-a-qualitative-study
#37
JOURNAL ARTICLE
Dhruv Khullar, William L Schpero, Lawrence P Casalino, Reekarl Pierre, Samuel Carter, Yasin Civelek, Manyao Zhang, Amelia M Bond
IMPORTANCE: The Medicare Shared Savings Program (MSSP) includes more than 400 accountable care organizations (ACOs) and is among the largest and longest running value-based payment efforts in the US. However, given recent program reforms and other changes in the health care system, the experiences and perspectives of ACO leaders remain incompletely characterized. OBJECTIVE: To understand the priorities, strategies, and challenges of ACO leaders in MSSP. DESIGN, SETTING, AND PARTICIPANTS: In this qualitative study, interviews were conducted with leaders of 49 ACOs of differing sizes, leadership structures, and geographies from MSSP between September 29 and December 29, 2022...
March 1, 2024: JAMA health forum
https://read.qxmd.com/read/38477198/-not-available
#38
JOURNAL ARTICLE
Meriam Mahfoudh, Dorra Cherif, Raja M'chirgui, Nadia Fenina
INTRODUCTION: Access to medication is a major public health issue worldwide and can be considered as an indicator of the quality of public health services in a country. AIM: To evaluate patient satisfaction with the services provided by the external pharmacy in the drug distribution circuit in public healthcare facilities in Tunisia. METHODS: To achieve this goal, a satisfaction survey was conducted on a sample of 200 patients at the external pharmacies of two university hospitals in Tunis, namely the La Rabta University Hospital and the Charles Nicolle University Hospital...
December 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38476083/impact-of-the-covid-19-pandemic-on-employment-and-inequalities-a-systematic-review-of-international-evidence-and-critical-appraisal-of-statistical-methods
#39
JOURNAL ARTICLE
A Abugamza, D Kaskirbayeva, A Charlwood, S Nikolova, A Martin
AIMS: To assess the impact of the COVID-19 pandemic on individual labour market outcomes and how these vary over time and between different groups of individuals. METHODS: Searches were conducted using Medline, Scopus and EconLit. Grey literature searches used Google Scholar and Econpapers. Study quality was assessed using the risk of bias in non-randomised studies of exposure tool (ROBINS-E), accompanied by a directed acyclic graph (DAG) to identify relevant mediators, moderators and confounders...
March 13, 2024: Perspectives in Public Health
https://read.qxmd.com/read/38470938/validation-of-touchb-a-non-invasive-haemoglobin-estimation-effective-for-normal-ranges-needs-improvement-for-anaemia-detection
#40
JOURNAL ARTICLE
Yogish Channa Basappa, Sumanth Mallikarjuna Majgi, Shashidhar Byrappa Shashidhar, Prashanth Nuggehalli Srinivas
Non-invasive methods for haemoglobin estimation hold enormous potential for early detection and treatment of anaemia, especially in limited resource settings. We sought to validate the diagnostic accuracy of ToucHb, a non-invasive haemoglobin estimation device available in the Indian market. We prospectively evaluated the diagnostic performance of the ToucHb device using the Automated complete blood count (CBC) method as the gold standard. Persons referred for haemoglobin estimation to the central laboratory of the government medical college hospital in Mysore, southern India were included in the study...
2024: PLOS Glob Public Health
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