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https://www.readbyqxmd.com/read/28526171/chlorhexidine-gluconate-or-polyhexamethylene-biguanide-disc-dressing-to-reduce-the-incidence-of-central-line-associated-bloodstream-infection-a-feasibility-randomized-controlled-trial-the-clabsi-trial
#1
J Webster, E Larsen, N Marsh, A Choudhury, P Harris, C M Rickard
BACKGROUND: A number of antimicrobial-impregnated discs to prevent central-line-associated bloodstream infection (CLABSI) are marketed but it is unclear which disc is most effective. AIM: To investigate the feasibility and safety of comparing two antimicrobial-impregnated discs to prevent CLABSI. METHODS: A single-centre, parallel group, randomized controlled trial was conducted in a 929-bed tertiary referral hospital. Hospital inpatients requiring a peripherally inserted central catheter were randomized to chlorhexidine gluconate (CHG) or polyhexamethylene biguanide (PHMB) disc dressing group...
April 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28522642/influence-of-drug-class-and-healthcare-setting-on-systemic-antifungal-expenditures-in-the-united-states-2005-15
#2
Margaret A Fitzpatrick, Katie J Suda, Charlesnika T Evans, Robert J Hunkler, Frances Weaver, Glen T Schumock
PURPOSE: Overall and specific class trends in systemic antifungal expenditures in various U.S. healthcare settings from 2005 through 2015 were evaluated. METHODS: Systemic antifungal expenditures from January 1, 2005, through December 31, 2015, were obtained from the QuintilesIMS National Sales Perspective database, which provides a statistically valid projection of medication purchases from multiple markets throughout the United States. Summary data for total antifungal expenditures over the entire period are reported, as are growth and the percentage change in expenditures from one year to the next...
May 18, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28515521/comparative-evaluation-of-airtraq%C3%A2-optical-laryngoscope-and-miller-s-blade-in-paediatric-patients-undergoing-elective-surgery-requiring-tracheal-intubation-a-randomized-controlled-trial
#3
Bikramjit Das, Arijit Samanta, Subhro Mitra, Shahin Nikhat Jamil
BACKGROUND AND AIMS: The Airtraq™ optical laryngoscope is the only marketed videolaryngoscope for paediatric patients besides the fibre-optic bronchoscope. We hypothesized that intubation would be easier with Airtraq™ compared to Miller blade. Hence, we compared Airtraq™ with the Miller laryngoscope as intubation devices in paediatric patients. METHODS: This prospective, randomized study was conducted in a tertiary care teaching hospital. Sixty children belonging to American Society of Anesthesiologists' Grade I-II, aged 2-10 years, posted for routine surgery requiring tracheal intubation were randomly allocated to undergo intubation using a Miller (n = 30) or Airtraq™ (n = 30) laryngoscope...
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28512663/advancing-the-integration-of-hospital-it-pitfalls-and-perspectives-when-replacing-specialized-software-for-high-risk-environments-with-enterprise-system-extensions
#4
Carsten Engelmann, Dzifa Ametowobla
BACKGROUND: Planning and controlling surgical operations hugely impacts upon productivity, patient safety, and surgeons' careers. Established, specialized software for this task is being increasingly replaced by "Operating Room (OR)-modules" appended to enterprise-wide resource planning (ERP) systems. As a result, usability problems are re-emerging and require developers' attention. OBJECTIVE: Systematic evaluation of the functionality and social repercussions of a global, market-leading IT business control system (SAP R3, Germany), adapted for real-time OR process steering...
May 17, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28510497/clinical-development-and-commercialization-of-advanced-therapy-medicinal-products-atmps-in-the-eu-how-are-the-product-pipeline-and-regulatory-framework-evolving
#5
Tomáš Boráň, Margarida Menezes-Ferreira, Ilona Reischl, Patrick Celis, Nicolas Ferry, Bernd Gänsbacher, Hartmut Krafft, Michele Lipucci Di Paola, Dariusz Sladowski, Paula Salmikangas
The research and development of Advanced Therapy Medicinal Products (ATMPs) has been active in Europe and worldwide during recent years, yet the number of licensed products remains still low. The main expected legal change in near future in the EU concerns the regulation on clinical trials (536/2014), which will come into force in 2018. With this new framework a more harmonized and swift process for approval of clinical trials is awaited, which is expected to support the entry of new innovations into the EU market...
May 16, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28509711/trends-in-governance-structure-and-activities-among-not-for-profit-u-s-hospitals-2009-2015
#6
Olena Mazurenko, Taleah Collum, Nir Menachemi
BACKGROUND: In U.S. hospitals, boards of directors (BODs) have numerous governance responsibilities including overseeing hospital activities and guiding strategic decisions. BODs can help hospitals adapt to changes in their markets including those stemming from a shift from fee-for-service to value-based purchasing. The recent increase in market turbulence for hospitals has brought renewed attention to the work of BODs. PURPOSE: The aim of the study was to examine trends in hospital BOD structure and activities and determine whether these changes are commensurate with approaches designed to respond to market pressures...
May 15, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28505601/the-association-between-attempted-suicide-and-stock-price-movements-evidence-from-taiwan
#7
Chung-Liang Lin, Tsai-Ching Liu, Chin-Shyan Chen
This study is the first comprehensive analysis to investigate the potential association between stock market fluctuations and attempted suicide events as measured by self-inflicted injuries treated in hospitalization. Using nationwide, 15-year population-based data from 1998 through 2012, we observe that the occurrences for the hospitalizations of attempted suicides are apparently predicted by stock price movements. A low stock price index, a daily fall in the stock index, and consecutive daily falls in the stock index have been shown to be associated with increased risk of hospitalization in patients with attempted suicide...
May 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28499318/-psychiatric-inpatient-treatment-and-return-to-work
#8
Lena Mernyi, Patricia Hölzle, Johannes Hamann
Objective People with mental diseases have a high risk of unemployment and they have only limited access to the labor market. The return to work is often associated with fears.The present study aims to provide an overview of the number of hospitalized psychiatric patients with permanent employment. Moreover it should give an insight into the process of return to work, the experiences patients gain and the support they receive. Methods In the participating clinics we measured the number of patients with permanent employment...
May 12, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28498849/percutaneous-coronary-intervention-with-second-generation-drug-eluting-stent-versus-bare-metal-stent-systematic-review-and-cost-benefit-analysis
#9
Thomas G Poder, Jihane Erraji, Lucien P Coulibaly, Kouamé Koffi
BACKGROUND: Drug-eluting stents (DESs) were considered as ground-breaking technology promising to eradicate restenosis and the necessity to perform multiple revascularization procedures subsequent to percutaneous coronary intervention. Soon after DESs were released on the market, however, there were reports of a potential increase in mortality and of early or late thrombosis. In addition, DESs are far more expensive than bare-metal stents (BMSs), which has led to their limited use in many countries...
2017: PloS One
https://www.readbyqxmd.com/read/28498575/implementing-shared-decision-making-in-routine-mental-health-care
#10
Mike Slade
Shared decision making (SDM) in mental health care involves clinicians and patients working together to make decisions. The key elements of SDM have been identified, decision support tools have been developed, and SDM has been recommended in mental health at policy level. Yet implementation remains limited. Two justifications are typically advanced in support of SDM. The clinical justification is that SDM leads to improved outcome, yet the available empirical evidence base is inconclusive. The ethical justification is that SDM is a right, but clinicians need to balance the biomedical ethical principles of autonomy and justice with beneficence and non-maleficence...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28496330/differential-cardiovascular-profiles-of-sodium-glucose-cotransporter-2-inhibitors-critical-evaluation-of-empagliflozin
#11
REVIEW
Vani P Sanon, Shalin Patel, Saurabh Sanon, Ruben Rodriguez, Son V Pham, Robert Chilton
One of the most feared repercussions of type 2 diabetes mellitus is the risk of adverse cardiovascular outcomes. The current antidiabetic agents on the market have had difficulty in showing cardiovascular outcome improvement. The EMPA-REG OUTCOME trial studied the sodium-glucose cotransporter 2 inhibitor empagliflozin in type 2 diabetic patients at high risk of cardiovascular events. The trial results revealed a decrease in the composite primary end points of death from cardiovascular causes, nonfatal myocardial infarction, and nonfatal stroke in those taking empagliflozin vs placebo...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28493481/hospital-and-health-insurance-markets-concentration-and-inpatient-hospital-transaction-prices-in-the-u-s-health-care-market
#12
Seidu Dauda
OBJECTIVE: To examine the effects of hospital and insurer markets concentration on transaction prices for inpatient hospital services. DATA SOURCES: Measures of hospital and insurer markets concentration derived from American Hospital Association and HealthLeaders-InterStudy data are linked to 2005-2008 inpatient administrative data from Truven Health MarketScan Databases. STUDY DESIGN: Uses a reduced-form price equation, controlling for cost and demand shifters and accounting for possible endogeneity of market concentration using instrumental variables (IV) technique...
May 11, 2017: Health Services Research
https://www.readbyqxmd.com/read/28491101/geospatial-assessment-of-cholera-in-a-rapidly-urbanizing-environment
#13
Olajumoke Esther Olanrewaju, Kayode Adewale Adepoju
This study mapped out and investigated the spatial relationship between cholera incidences and environmental risk factors in the study area. The study area was stratified into eight zones. Water samples from each zone were collected and analyzed to determine the colony forming units. GIS layers including housing density, digitized roads, rivers, buildings, and cholera incidence data from hospital archives were also collected and analyzed using ArcGIS 10.1. It was observed that there was an association between the ERFs (p < 0...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28486279/payor-reform-opportunities-for-spine-surgery-part-i-background-and-stimulus-for-bundled-payments
#14
Jason Scalise, David Jacofsky
Spine surgery, and orthopedic surgery overall, is being increasingly scrutinized by payors due to large projected increases in utilization. The unsustainability of the fee-for-service payment system has lead payors to investigate novel value and risk-based contracting strategies on an episode of care basis and on a population health basis. These forays into progressive models for spine surgery have been supported by the successes demonstrated by advanced payor reform programs from The Centers for Medicare and Medicaid Services in other areas of musculoskeletal medicine...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28485716/the-former-yugoslav-republic-of-macedonia-health-system-review
#15
Neda Milevska Kostova, Snezhana Chichevalieva, Ninez A Ponce, Ewout van Ginneken, Juliane Winkelmann
This analysis of the health system of the former Yugoslav Republic of Macedonia reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. The country has made important progress during its transition from a socialist system to a market-based system, particularly in reforming the organization, financing and delivery of health care and establishing a mix of private and public providers. Though total health care expenditure has risen in absolute terms in recent decades, it has consistently fallen as share of GDP, and high levels of private health expenditure remain...
May 2017: Health Systems in Transition
https://www.readbyqxmd.com/read/28485714/portugal-health-system-review
#16
Jorge de Almeida Simoes, Goncalo Figueiredo Augusto, Ines Fronteira, Cristina Hernandez-Quevedo
This analysis of the Portuguese health system reviews recent developments in organization and governance, health financing, health care provision, health reforms and health system performance. Overall health indicators such as life expectancy at birth and at age 65 years have shown a notable improvement over the last decades. However, these improvements have not been followed at the same pace by other important dimensions of health: child poverty and its consequences, mental health and quality of life after 65...
March 2017: Health Systems in Transition
https://www.readbyqxmd.com/read/28483246/comparison-of-first-year-of-life-acute-otitis-media-admissions-before-and-after-the-13-valent-pneumococcal-conjugate-vaccine
#17
Tal Marom, Ofer Israel, Haim Gavriel, Jacob Pitaro, Ali Abo Baker, Ephraim Eviatar
BACKGROUND: Acute otitis media (AOM) is a common childhood infection, which is usually managed in the outpatient setting. Yet, the more severe cases are referred for inpatient treatment. We hypothesized that pneumococcal conjugate vaccines (PCVs), administered during the first year of life, would decrease AOM admissions rate in this age group. We studied the characteristics of infants admitted with AOM and acute mastoiditis (AM) in the PCV13 era, routinely given from November 2010 to all infants...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28482066/do-hospital-characteristics-influence-cesarean-delivery-analysis-of-national-health-insurance-claim-data
#18
Kyu-Tae Han, Seung Ju Kim, Yeong Jun Ju, Jong Won Choi, Eun-Cheol Park
The rates of Cesarean delivery in South Korea are high among the Organization for Economic Cooperation and Development countries. We analyzed the relationship between hospital characteristics, in particular hospital volume and market competition and Cesarean delivery. We used data from National Health Insurance claims ( n = 53 591) at 51 hospitals to analyze the relationship between hospital characteristics and Cesarean delivery between 2010 and 2013. We performed logistic regression analysis using generalized estimating equations models that included both inpatient and hospital variables to examine factors associated with Cesarean delivery Among 53 591 hospitalization cases, 14 425 (26...
May 7, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28480733/accuracy-evaluation-of-19-blood-glucose-monitoring-systems-manufactured-in-the-asia-pacific-region-a-multicenter-study
#19
Wang Yu-Fei, Jia Wei-Ping, Wu Ming-Hsun, Chien Miao-O, Hsieh Ming-Chang, Wang Chi-Pin, Lee Ming-Shih
BACKGROUND: System accuracy of current blood glucose monitors (BGMs) in the market has already been evaluated extensively, yet mostly focused on European and North American manufacturers. Data on BGMs manufactured in the Asia-Pacific region remain to be established. In this study, we sought to assess the accuracy performance of 19 BGMs manufactured in the Asia-pacific region. METHODS: A total of 19 BGMs were obtained from local pharmacies in China. The study was conducted at three hospitals located in the Asia-Pacific region...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28479791/minimally-invasive-versus-open-spine-surgery-what-does-the-best-evidence-tell-us
#20
Shearwood McClelland, Jeffrey A Goldstein
BACKGROUND: Spine surgery has been transformed significantly by the growth of minimally invasive surgery (MIS) procedures. Easily marketable to patients as less invasive with smaller incisions, MIS is often perceived as superior to traditional open spine surgery. The highest quality evidence comparing MIS with open spine surgery was examined. METHODS: A systematic review of randomized controlled trials (RCTs) involving MIS versus open spine surgery was performed using the Entrez gateway of the PubMed database for articles published in English up to December 28, 2015...
April 2017: Journal of Neurosciences in Rural Practice
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