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https://www.readbyqxmd.com/read/29028656/costs-and-benefits-of-on-demand-hiv-pre-exposure-prophylaxis-in-men-who-have-sex-with-men-analysis-of-the-anrs-ipergay-study-with-a-one-year-follow-up
#1
Isabelle Durand-Zaleski, Pierre Mutuon, Isabelle Charreau, Cecile Tremblay, Daniela Rojas, Gilles Pialoux, Christian Chidiac, Catherine Capitant, Bruno Spire, Laurent Cotte, Julie Chas, Laurence Meyer
OBJECTIVES: We undertook the economic evaluation of the double-blind randomized ANRS-IPERGAY trial which showed the efficacy of on-demand pre-exposure prophylaxis (PrEP) with tenofovir-disoproxil-fumarate (TDF-FTC) in preventing HIV infection among high risk men-who have-sex-with-men (MSM). DESIGN & METHODS: The economic evaluation was prospective. Counseling, drugs (TDF-FTC at &OV0556;500.88 for 30 tablets), tests, visits and hospital admissions were valued based on in-trial use...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29026483/hospital-charges-and-continuity-of-care-for-outpatients-with-hypertension-in-south-korea-a-nationwide-population-based-cohort-study-from-2002-to-2013
#2
Jae-Hyun Kim, Eun-Cheol Park, Tae Hyun Kim, Yunhwan Lee
BACKGROUND: Continuity of care (COC) has received attention over the past decade. COC has also become increasingly important for hospital managers and policy makers because of competitive health care market conditions. The purpose of this study was to assess the association between hospital charges and patients' continuity of care-assessed by three indices of continuity of care-among outpatients with hypertension in South Korea. METHODS: This study used the National Health Insurance Service-Cohort Sample Database from 2002 to 2013...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29024092/pharmaceutical-opioid-use-and-harm-in-australia-the-need-for-proactive-and-preventative-responses
#3
Briony Larance, Louisa Degenhardt, Amy Peacock, Natasa Gisev, Richard Mattick, Samantha Colledge, Gabrielle Campbell
There are parallels between the North American experience of escalating pharmaceutical opioid utilisation and harm and the trends being observed in Australia. In Australia, opioid utilisation has increased dramatically over the past two decades. There have been significant shifts away from the predominant prescribing of 'weak' and short-acting opioids, to 'strong' and long-acting opioids, for an increasing range of chronic pain indications. In concordance with escalating use, Australia is experiencing increases in opioid-related hospital admissions and overdose, as well as opioid dependence and treatment seeking...
October 12, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29019083/microbial-stability-of-pharmaceutical-and-cosmetic-products
#4
REVIEW
Huy Dao, Prit Lakhani, Anitha Police, Venkataraman Kallakunta, Sankar Srinivas Ajjarapu, Kai-Wei Wu, Pranav Ponkshe, Michael A Repka, S Narasimha Murthy
This review gives a brief overview about microbial contamination in pharmaceutical products. We discuss the distribution and potential sources of microorganisms in different areas, ranging from manufacturing sites, pharmacy stores, hospitals, to the post-market phase. We also discuss the factors that affect microbial contamination in popular dosage forms (e.g., tablets, sterile products, cosmetics). When these products are contaminated, the microorganisms can cause changes. The effects range from mild changes (e...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28990800/a-robust-analysis-of-hospital-efficiency-and-factors-affecting-variability
#5
Herve Leleu, Mona Al-Amin, Michael Rosko, Vivian G Valdmanis
The objectives of this paper are to use data envelopment analysis to measure hospital inefficiency in a way that accounts for patient outcomes and to study the association between organizational factors, such as hospital-physicians integration level and teaching status, and market competition with hospital inefficiency. We apply the robust data envelopment analysis approach to a sample of private (both not-for-profit and for-profit) hospitals operating in the United States. Our data envelopment analysis model includes mortality and readmission rates as bad outputs and admissions, surgeries, emergency room, and other visits as good outputs...
January 1, 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28989245/plants-natural-products-as-alternative-promising-anti-candida-drugs
#6
REVIEW
Sameh Soliman, Dina Alnajdy, Ali A El-Keblawy, Kareem A Mosa, Ghalia Khoder, Ayman M Noreddin
Candida is a serious life-threatening pathogen, particularly with immunocompromised patients. Candida infections are considered as a major cause of morbidity and mortality in a broad range of immunocompromised patients. Candida infections are common in hospitalized patients and elderly people. The difficulty to eradicate Candida infections is owing to its unique switch between yeast and hyphae forms and more likely to biofilm formations that render resistance to antifungal therapy. Plants are known sources of natural medicines...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28980020/-digital-electroencephalography-in-brain-death-diagnostics-technical-requirements-and-results-of-a%C3%A2-survey-on-the-compatibility-with-medical-guidelines-of-digital-eeg-systems-from-providers-in-germany
#7
U Walter, S Noachtar, H Hinrichs
BACKGROUND: The guidelines of the German Medical Association and the German Society for Clinical Neurophysiology and Functional Imaging (DGKN) require a high procedural and technical standard for electroencephalography (EEG) as an ancillary method for diagnosing the irreversible cessation of brain function (brain death). Nowadays, digital EEG systems are increasingly being applied in hospitals. So far it is unclear to what extent the digital EEG systems currently marketed in Germany meet the guidelines for diagnosing brain death...
October 4, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28969109/prevalence-of-iron-deficiency-and-iron-deficiency-anaemia-in-adolescent-girls-in-a-tertiary-care-hospital
#8
Rekha Kumari, Raushan Kumar Bharti, Kalpana Singh, Archana Sinha, Sudhir Kumar, Anand Saran, Uday Kumar
INTRODUCTION: Iron Deficiency Anaemia (IDA) is a global health problem. It involves population of all age group and sex. But adolescent girls are more vulnerable to it. The reasons may be increased iron demand, menstrual blood loss, infection, worm infestation etc. AIM: To find the prevalence of iron deficiency and IDA in adolescent girls in a Tertiary Care Hospital. MATERIALS AND METHODS: This cross-sectional study was done in the biochemistry clinical laboratory of Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India for a period of six months (April 2015-October 2015)...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28965792/what-do-women-want-valuing-women-s-preferences-and-estimating-demand-for-alternative-models-of-maternity-care-using-a-discrete-choice-experiment
#9
Christopher G Fawsitt, Jane Bourke, Richard A Greene, Brendan McElroy, Nicolas Krucien, Rosemary Murphy, Jennifer E Lutomski
In many countries, there has been a considerable shift towards providing a more woman-centred maternity service, which affords greater consumer choice. Maternity service provision in Ireland is set to follow this trend with policymakers committed to improving maternal choice at hospital level. However, women's preferences for maternity care are unknown, as is the expected demand for new services. In this paper, we used a discrete choice experiment (DCE) to (1) investigate women's strengths of preference for different features of maternity care; (2) predict market uptake for consultant- and midwifery-led care, and a hybrid model of care called the Domiciliary In and Out of Hospital Care scheme; and (3) calculate the welfare change arising from the provision of these services...
September 23, 2017: Health Policy
https://www.readbyqxmd.com/read/28964456/do-robotic-surgical-systems-improve-profit-margins-a-cross-sectional-analysis-of-california-hospitals
#10
COMPARATIVE STUDY
Ya-Chen Tina Shih, Chan Shen, Jim C Hu
BACKGROUND: The aim of this study was to examine the association between ownership of robotic surgical systems and hospital profit margins. METHODS: This study used hospital annual utilization data, annual financial data, and discharge data for year 2011 from the California Office of Statewide Health Planning and Development. We first performed bivariate analysis to compare mean profit margin by hospital and market characteristics and to examine whether these characteristics differed between hospitals that had one or more robotic surgical systems in 2011 and those that did not...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28963987/how-the-built-environment-affects-change-in-older-people-s-physical-activity-a-mixed-methods-approach-using-longitudinal-health-survey-data-in-urban-china
#11
Peiling Zhou, Sue C Grady, Guo Chen
Although the general population in China is physically active, only 45% of older adults meet the World Health Organization's recommendation for weekly moderate-to-vigorous exercise, to achieve health benefits. This percentage is even lower (9.8%) in urban China. It is, therefore, important to understand the pathways by which physical activity behaviors are impacted by the built environment. This study utilized a mixed methods approach-interviews (n = 42) and longitudinal (2010-2015) health survey data (n = 3094) for older people residing in three neighborhoods in Huainan, a mid-sized city in Anhui Province, central eastern China...
September 22, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28961643/hospital-value-based-purchasing-the-association-between-patient-experience-and-clinical-outcome
#12
D Rob Haley, Hanadi Hamadi, Mei Zhao, Jing Xu, Yi Wang
The Affordable Care Act of 2010 introduced a Hospital Value-Based Purchasing Total Performance Score for payment purposes and to evaluate hospital quality of care. In fiscal year 2016, Total Performance Score was composed of (1) Clinical Processes of Care, (2) Patient Experience of Care, (3) Outcome, and (4) Efficiency domains. The objective of this study was to examine the association between the Patient Experience of Care and Outcome domains. The Donabedian model of structure, process, and outcome was used as a conceptual framework for this study...
September 28, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28956449/dorzolamide-nanoliposome-as-a-long-action-ophthalmic-delivery-system-in-open-angle-glaucoma-and-ocular-hypertension-patients
#13
Maryam Kouchak, Mohammad Malekahmadi, Neda Bavarsad, Amal Saki Malehi, Laleh Andishmand
IMPORTANCE: reducing the frequency of dorzolamide eye drop administration and increasing the duration of action. BACKGROUND: This study aims to compare the effect of dorzolamide loaded- nanoliposome with marketed dorzolamide HCl eye drop on intraocular pressure in primary open angle glaucoma and ocular hypertension patients. DESIGN: A randomized study was conducted in a hospital. PARTICIPANTS: Twenty patients with primary open angle glaucoma or ocular hypertension (in both eyes) diagnosis were recruited as participants...
September 28, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28951666/knowledge-attitude-and-practices-of-pharmacovigilance-and-adverse-drug-reaction-reporting-among-pharmacists-working-in-secondary-and-tertiary-governmental-hospitals-in-kuwait
#14
Fatemah M Alsaleh, Sherifah W Alzaid, Eman A Abahussain, Tania Bayoud, Jacinthe Lemay
Introduction: Pharmacovigilance (PV) is essential to detect and prevent adverse drug reactions (ADR) after a drug is marketed. However, ADRs are significantly underreported worldwide. Objective: The aims of this study were to document the knowledge, attitude and practices (KAP) of pharmacists toward PV and ADR reporting and to explore the barriers to implementing a fully functional PV program in Kuwait. Material and methods: Pharmacists working at governmental hospitals were asked to complete a paper-based 25-item questionnaire...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28950856/new-zealand-s-emergency-department-target-did-it-reduce-ed-length-of-stay-and-if-so-how-and-when
#15
Tim Tenbensel, Linda Chalmers, Peter Jones, Sarah Appleton-Dyer, Lisa Walton, Shanthi Ameratunga
BACKGROUND: In 2009, the New Zealand government introduced a hospital emergency department (ED) target - 95% of patients seen, treated or discharged within 6 h - in order to alleviate crowding in public hospital EDs. While these targets were largely met by 2012, research suggests that such targets can be met without corresponding overall reductions in ED length-of-stay (LOS). Our research explores whether the NZ ED time target actually reduced ED LOS, and if so, how and when. METHODS: We adopted a mixed-methods approach with integration of data sources...
September 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28947415/prescribing-of-electronic-activity-monitors-in-cardiometabolic-diseases-qualitative-interview-based-study
#16
Alice Bellicha, Sandrine Macé, Jean-Michel Oppert
BACKGROUND: The prevalence of noncommunicable diseases, including those such as type 2 diabetes, obesity, dyslipidemia, and hypertension, so-called cardiometabolic diseases, is high and is increasing worldwide. Strong evidence supports the role of physical activity in management of these diseases. There is general consensus that mHealth technology, including electronic activity monitors, can potentially increase physical activity in patients, but their use in clinical settings remains limited...
September 23, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28946874/design-of-a-single-arm-clinical-trial-of-regenerative-therapy-by-periurethral-injection-of-adipose-derived-regenerative-cells-for-male-stress-urinary-incontinence-in-japan-the-adresu-study-protocol
#17
Shinobu Shimizu, Tokunori Yamamoto, Shinobu Nakayama, Akihiro Hirakawa, Yachiyo Kuwatsuka, Yasuhito Funahashi, Yoshihisa Matsukawa, Keisuke Takanari, Kazuhiro Toriyama, Yuzuru Kamei, Kazutaka Narimoto, Tomonori Yamanishi, Osamu Ishizuka, Masaaki Mizuno, Momokazu Gotoh
BACKGROUND: Male stress urinary incontinence is a prevalent condition after radical prostatectomy. While the standard recommendation for the management of urine leakage is pelvic floor muscle training, its efficacy is still unsatisfactory. Therefore, we have focused on regenerative therapy, which consists of administering a periurethral injection of autologous regenerative cells from adipose tissue, separated using the Celution® system. Based on an interim data analysis of our exploratory study, we confirmed the efficacy and acceptable safety profile of this treatment...
September 25, 2017: BMC Urology
https://www.readbyqxmd.com/read/28943593/nationwide-survey-on-informed-consent-and-ethical-review-at-hospitals-conducting-post-marketing-studies-sponsored-by-pharmaceutical-companies
#18
Hisashi Urushihara, Yuka Murakami, Kenji Matsui, Shimon Tashiro
<bibitem lang="en">  Under the Japanese drug regulatory system, post-marketing studies (PMS) must be in compliance with Good Post-marketing Study Practice (GPSP). The GPSP Ordinance lacks standards for the ethical conduct of PMSs; although only post-marketing clinical trials are subject to Good Clinical Practice. <bibitem lang="en">  We conducted a web-based questionnaire survey on the ethical conduct of PMSs in collaboration with the Japanese Society of Hospital Pharmacists and pharmacists belonging to the Society...
September 25, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28941622/epidemiology-of-childhood-intussusception-in-bangladesh-findings-from-an-active-national-hospital-based-surveillance-system-2012-2016
#19
Syed M Satter, Negar Aliabadi, Catherine Yen, Paul A Gastañaduy, Makhdum Ahmed, Abdullah Mamun, Khaleda Islam, Meerjady S Flora, Mahmudur Rahman, K Zaman, Mustafizur Rahman, James D Heffelfinger, Stephen P Luby, Emily S Gurley, Umesh D Parashar
INTRODUCTION: Rotavirus vaccines have significantly decreased the burden of diarrheal diseases in countries that have introduced them into their immunization programs. In some studies, there has been a small association between rotavirus vaccines and intussusception in post-marketing surveillance, highlighting the importance of tracking incidence before and after vaccine introduction. The objective of this study was to describe the epidemiology of intussusception among Bangladeshi children pre-vaccine introduction...
September 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28940919/do-public-hospitals-respond-to-changes-in-drg-price-regulation-the-case-of-birth-deliveries-in-the-italian-nhs
#20
Marina Di Giacomo, Massimiliano Piacenza, Luigi Siciliani, Gilberto Turati
We study how changes in Diagnosis-Related Group price regulation affect hospital behaviour in quasi-markets with exclusive provision by public hospitals. Exploiting a quasi-natural experiment, we use a difference-in-differences approach to test whether public hospitals respond to an exogenous change in Diagnosis-Related Group tariffs by increasing C-section rates and/or by upcoding. Controlling for a detailed set of mother characteristics, we find that price changes did not affect the probability of a C-section...
September 2017: Health Economics
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