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https://www.readbyqxmd.com/read/29166646/reconstruction-of-membrane-current-by-deconvolution-and-its-application-to-membrane-capacitance-measurements-in-cardiac-myocytes
#1
Matej Hoťka, Ivan Zahradník
Correct detection of membrane currents under whole-cell patch-clamp conditions is limited by the transfer function of a recording system. The low-pass output filter of a recording amplifier alters the time course of membrane current and causes errors in relevant descriptors. To solve these problems, we developed a practical procedure for reconstruction of the time course of membrane currents based on deconvolution of recorded currents in frequency domain. The procedure was tested on membrane capacitance estimates from current responses to step voltage pulses...
2017: PloS One
https://www.readbyqxmd.com/read/29166622/morphological-characteristics-and-variations-of-the-human-quadratus-plantae-muscle
#2
Bettina Pretterklieber
The quadratus plantae (QP) is a highly variable structure. A number of partly inexact descriptions of this entity have been provided in textbooks of anatomy. Although several authors have examined the QP, its exact site of origin and type of insertion have hitherto not been specified. The aim of this study has been to provide detailed qualitative and quantitative data about the number of heads, points of origin, and type of insertion of the QP. The QP in both feet of 50 formalin-fixed specimens of body donors (25 men and women) were analyzed by gross anatomical dissection...
November 19, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29165838/discordance-of-pediatric-morphea-treatment-by-pediatric-dermatologists
#3
Megha M Tollefson, Yvonne E Chiu, Heather A Brandling-Bennett, Elena Pope
BACKGROUND/OBJECTIVES: Studies describing treatment efficacy in pediatric morphea are lacking. Subspecialists have reached no consensus on how to optimally treat pediatric morphea. The objective of the current study was to describe the most common treatment practices of pediatric dermatologists worldwide who care for children with morphea. METHODS: A survey regarding topical treatment practices of pediatric morphea, with representative case-based scenarios, was distributed to pediatric dermatologists and results were tallied...
November 22, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29165601/associations-between-perceived-leadership-and-presenteeism-in-an-industrial-population
#4
Kimmo J Vänni, Subas Neupane, Clas-Håkan Nygård
Background: Presenteeism has received increasing attention in occupational health research but the evidence for its association with perceived leadership is scant. Aims: To assess the association of perceived leadership and presenteeism among industrial workers. Methods: Survey responses from employees on perceived leadership were linked to the personnel register of a food industry company. The Presenteeism Scale method was used to determine the presenteeism percentage...
November 19, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29165595/con-the-role-of-diet-for-people-with-advanced-stage-5-ckd
#5
Graham Woodrow
Restriction of dietary protein intake has been used in the management of chronic kidney disease (CKD) for many decades, yet remains controversial, with marked variations in its application in clinical practice. There is extensive literature on the subject, with some expert opinion advocating the use of protein restriction based on the balance of the available evidence. The largest randomized trial of low-protein diets is the Modification of Diet in Renal Disease study. Despite multiple secondary analyses, the essential intention-to-treat analysis failed to demonstrate a benefit in the primary outcome of rate of decline of glomerular filtration rate...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29165567/impact-of-the-pathologist-on-prostate-biopsy-diagnosis-and-immunohistochemical-stain-usage-within-a-single-institution
#6
Mit D Shah, Anil V Parwani, Debra L Zynger
Objectives: To determine whether pathologists in a tertiary care institution vary in diagnosis and immunohistochemical stain usage in prostate biopsy specimens. Methods: Men who underwent prostate needle biopsies between 2008 and 2013 were included. Results: In total, 1,777 prostate biopsy specimens diagnosed by nine pathologists showed variation in diagnostic reporting (atypical small acinar proliferation, 2.0%-8.0%; high-grade prostatic intraepithelial neoplasia, 2...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29163486/structure-and-diversity-of-the-rhesus-macaque-immunoglobulin-loci-through-multiple-de-novo-genome-assemblies
#7
Akshaya Ramesh, Sam Darko, Axin Hua, Glenn Overman, Amy Ransier, Joseph R Francica, Ashley Trama, Georgia D Tomaras, Barton F Haynes, Daniel C Douek, Thomas B Kepler
The rhesus macaque is a critically important animal model in biomedical research, most recently playing a key role in the development of vaccines against human immunodeficiency virus-1. Nevertheless, the immunoglobulin (Ig) loci of macaques are as yet incompletely determined and our understanding of differences between human and macaque humoral immunity remains deficient. We completed a high-coverage, high-quality whole genome sequencing and assembly project with a single rhesus macaque of Indian origin, and partial genome assemblies using genomic molecular targeting of the Ig loci in nine other rhesus macaques of Indian origin...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163284/creative-motor-actions-as-emerging-from-movement-variability
#8
Dominic Orth, John van der Kamp, Daniel Memmert, Geert J P Savelsbergh
In cognitive science, creative ideas are defined as original and feasible solutions in response to problems. A common proposal is that creative ideas are generated across dedicated cognitive pathways. Only after creative ideas have emerged, they can be enacted to solve the problem. We present an alternative viewpoint, based upon the dynamic systems approach to perception and action, that creative solutions emerge in the act rather than before. Creative actions, thus, are as much a product of individual constraints as they are of the task and environment constraints...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163261/a-sentence-repetition-task-for-catalan-speaking-typically-developing-children-and-children-with-specific-language-impairment
#9
Anna Gavarró
It is common to find that so-called minority languages enjoy fewer (if any) diagnostic tools than the so-called majority languages. This has repercussions for the detection and proper assessment of children with Specific Language Impairment (SLI) brought up in these languages. With a view to remedy this situation for Catalan, I developed a sentence repetition task to assess grammatical maturity in school-age children; in current practice, Catalan-speaking children are assessed with tests translated from Spanish, with disregard of the fact that the markers of SLI may differ substantially from one language to another, even between closely related languages...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29162753/assessment-of-pain-in-the-elderly-a-literature-review
#10
REVIEW
Yoon-Sook Kim, Jae-Min Park, Yeon-Sil Moon, Seol-Heui Han
BACKGROUND: Pain perception is highly subjective, and effective pain management can be challenging in the elderly. We aimed to identify a set of practical measures that could be used to assess pain in elderly patients with or without cognitive impairment, as the first step towards effectively managing their pain. METHODS: We used the PRISMA guidelines for this literature review. Two reviewers independently assessed titles, abstracts and full-text articles, and a third reviewer resolved any disagreements...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29162695/parallel-epigenetic-modifications-induced-by-hatchery-rearing-in-a-pacific-salmon
#11
Jérémy Le Luyer, Martin Laporte, Terry D Beacham, Karia H Kaukinen, Ruth E Withler, Jong S Leong, Eric B Rondeau, Ben F Koop, Louis Bernatchez
Wild stocks of Pacific salmonids have experienced sharp declines in abundance over the past century. Consequently, billions of fish are released each year for enhancing abundance and sustaining fisheries. However, the beneficial role of this widely used management practice is highly debated since fitness decrease of hatchery-origin fish in the wild has been documented. Artificial selection in hatcheries has often been invoked as the most likely explanation for reduced fitness, and most studies to date have focused on finding signatures of hatchery-induced selection at the DNA level...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29162681/clusters-of-practice-in-peritoneal-dialysis-in-france-data-from-the-catheter-section-of-the-rdplf
#12
Antoine Lanot, Clemence Bechade, Christian Verger, Emmanuel Fabre, Isabelle Vernier, Thierry Lobbedez
BACKGROUND: Peritonitis is a major cause of peritoneal dialysis (PD) failure. Recommendations for the prevention of peritonitis are available, but wide variations exist in the peritonitis rate among countries and PD units. The objective of this study was to describe the different pattern of practices in France. METHODS: This was a retrospective, multicenter study based on data from the French Language Peritoneal Dialysis Registry. Center practices were described and mapped...
November 21, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29162575/patient-and-practice-characteristics-predicting-attendance-and-completion-at-a-specialist-weight-management-service-in-the-uk-a-cross-sectional-study
#13
David N Blane, Philip McLoone, David Morrison, Sara Macdonald, Catherine A O'Donnell
OBJECTIVE: To determine the association between patient and referring practice characteristics and attendance and completion at a specialist health service weight management service (WMS). DESIGN: Cross-sectional study. SETTING: Regional specialist WMS located in the West of Scotland. PARTICIPANTS: 9677 adults with obesity referred between 2012 and 2014; 3250 attending service and 2252 completing. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome measure was attendance at the WMS; secondary outcome was completion, defined as attending four or more sessions...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29162090/assessment-of-motivational-interviewing-a-qualitative-study-of-response-process-validity-content-validity-and-feasibility-of-the-motivational-interviewing-target-scheme-mits-in-general-practice
#14
Riëtta Oberink, Saskia M Boom, Nynke van Dijk, Mechteld R M Visser
BACKGROUND: The Motivational Interviewing target Scheme (MITS) is an instrument to assess competency in Motivational Interviewing (MI) and can be used to assess MI in long and brief consultations. In this qualitative study we examined two sources of the Unified Model of Validity, the current standard of assessment validation, in the context of General Practice. We collected evidence concerning response process validity and content validity of the MITS in general practice. Furthermore, we investigated its feasibility...
November 21, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29161642/microbial-diversity-of-consumption-milk-during-processing-and-storage
#15
Davide Porcellato, Marina Aspholm, Siv Borghild Skeie, Marte Monshaugen, Johanne Brendehaug, Hilde Mellegård
Bovine milk contains a complex microbial community that affects the quality and safety of the product. Detailed knowledge of this microbiota is, therefore, of importance for the dairy industry. In this study, the bacterial composition of consumption milk was assessed during different stages in the production line and throughout the storage in cartons by using culturing techniques and 16S rRNA marker gene sequencing. Monthly samples from two dairies were analyzed to capture the seasonal variations in the milk microbiota...
November 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29159958/evaluation-of-a-low-risk-mild-traumatic-brain-injury-and-intracranial-hemorrhage-emergency-department-observation-protocol
#16
Brian J Yun, Pierre Borczuk, Lulu Wang, Stephen Dorner, Benjamin A White, Ali S Raja
OBJECTIVES: Among emergency physicians, there is wide variation in admitting practices for patients who suffered a mild traumatic brain injury (TBI) with an intracranial hemorrhage (ICH). The purpose of this study was to evaluate the effects of implementing a protocol in the emergency department (ED) observation unit for patients with mild TBI and ICH. METHODS: This retrospective cohort study was approved by the Institutional Review Board. Study subjects were patients ≥18 years of age with an International Classification of Diseases (ICD) code corresponding to a traumatic IC, and admitted to an ED observation unit (EDOU) of an urban, academic level 1 trauma center between February 1, 2015 and January 31, 2017...
November 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29159404/variation-in-the-12-month-treatment-trajectories-of-children-and-adolescents-after-a-diagnosis-of-depression
#17
Nina R Joyce, Megan S Schuler, Scott E Hadland, Laura A Hatfield
Importance: Depression during childhood and adolescence is heterogeneous. Treatment patterns are often examined in aggregate, yet there is substantial variability across individual treatment trajectories. Understanding this variability can help identify treatment gaps among youths with depression. Objective: To characterize heterogeneity in 12-month trajectories of psychotherapy and antidepressant treatment in youths with depression. Design, Setting, and Participants: This is a longitudinal-cohort study of youths 18 years or younger with a new diagnosis of depression and at least 12 months of follow-up following diagnosis, as determined from commercial insurance claims filed from 2007 to 2014...
November 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29159005/field-specific-intensity-modulated-proton-therapy-optimization-technique-for-breast-cancer-patients-with-tissue-expanders-containing-metal-ports
#18
Maura Kirk, Gary Freedman, Thorsten Ostrander, Lei Dong
This report aims to propose and present an evaluation of a robust pencil beam scanning proton multi-field optimized treatment planning technique for postmastectomy radiation of breast cancer patients with implanted tissue expanders containing an internal metal port. Field-specific split targets were created for optimization to prevent spots from traveling through the metal port, while providing uniform coverage of the target with the use of a multi-field intensity modulated optimization approach. Two beam angles were strategically selected to provide complementary target coverage and plan robustness...
September 18, 2017: Curēus
https://www.readbyqxmd.com/read/29158616/validation-of-the-vert-wearable-jump-monitor-device-in-elite-youth-volleyball-players
#19
Thiago O Borges, Alexandre Moreira, Renato Bacchi, Ronaldo L Finotti, Mayara Ramos, Charles R Lopes, Marcelo S Aoki
This technical report aims to determine the validity and the accuracy of the VERT Wearable Jump Monitor. The participants of this study were all experienced volleyball players from the U18 category from the Brazilian National team. To assess jump performance, the VERT scores were compared to the VERTEC (jump and reach device). Each athlete performed 3 attack and 3 block jumps in a random, counterbalanced order, and the average score was registered. In the attack jumps, the VERTEC and VERT mean ± SD scores were 70...
September 2017: Biology of Sport
https://www.readbyqxmd.com/read/29158245/variations-in-presentation-management-and-patient-outcomes-of-urinary-tract-infection-a-prospective-four-country-primary-care-observational-cohort-study
#20
Christopher C Butler, Nick Francis, Emma Thomas-Jones, Carl Llor, Emily Bongard, Michael Moore, Paul Little, Janine Bates, Mandy Lau, Timothy Pickles, Micaela Gal, Mandy Wootton, Nigel Kirby, David Gillespie, Kate Rumbsy, Curt Brugman, Kerenza Hood, Theo Verheij
BACKGROUND: Regional variations in the presentation of uncomplicated urinary tract infection (UTI) and pathogen sensitivity to antibiotics have been cited as reasons to justify differences in how the infections are managed, which includes the prescription of broad-spectrum antibiotics. AIM: To describe presentation and management of UTI in primary care settings, and explore the association with patient recovery, taking microbiological findings and case mix into account...
November 20, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
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