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https://www.readbyqxmd.com/read/29026579/amlodipine-induced-gingival-enlargement
#1
Abhilash Koratala, Indirakshi Jamalpur, Harikrishna Reddy Mogili
The three most common classes of medications implicated in drug-induced gum enlargement are anticonvulsives, calcineurin inhibitors, and calcium channel blockers. Treatment primarily consists of withdrawing the offending agent whenever possible, in addition to maintaining good oral hygiene. Gingivectomy or flap surgery may be needed in resistant cases.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29022534/therapeutic-drug-monitoring-of-amlodipine-and-the-z-fhl-hhl-ratio-adherence-tools-in-patients-referred-for-apparent-treatment-resistant-hypertension
#2
E S W Jones, M Lesosky, M Blockman, S Castel, E H Decloedt, S L U Schwager, E D Sturrock, L Wiesner, B L Rayner
BACKGROUND: Non-adherence to antihypertensives is a cause of 'pseudo-treatment-resistant' hypertension. OBJECTIVE: To determine whether monitoring plasma amlodipine concentrations and inhibition of angiotensin-converting enzyme (ACE) can be adjunct adherence tools. METHODS: Patients with hypertension who were prescribed enalapril and amlodipine were enrolled. Blood pressures (BPs) were monitored and an adherence questionnaire was completed...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28987246/influence-of-prevalent-and-incident-atrial-fibrillation-on-post-trial-major-events-in-allhat
#3
L Julian Haywood, Barry R Davis, Linda B Piller, William C Cushman, Jeffrey A Cutler, Charles E Ford, Lara M Simpson, Alokananda Ghosh, Elsayed Z Soliman, Jackson T Wright
AIMS: Limited information is available on long-term antihypertensive and lipid-lowering therapy effects on hypertensive patients with atrial fibrillation/flutter (AF/AFL) compared to those without. AF/AFL at baseline or during the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) (mean follow-up 4.9 years) markedly increased risk of stroke, heart failure, CHD, and all-cause mortality. We aimed to determine if AF/AFL continued to impact outcomes during post-trial follow-up (mean 3...
2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28976420/validated-lc-ms-ms-method-for-the-simultaneous-determination-of-amlodipine-and-its-major-metabolites-in-human-plasma-of-hypertensive-patients
#4
Reina Taguchi, Takafumi Naito, Hikaru Sato, Junichi Kawakami
BACKGROUND: No information on the pharmacokinetic characteristics of amlodipine (AML) metabolites is available. This study aimed to develop a method based on isocratic liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of AML and its two major metabolites, dehydroamlodipine (DH-AML) and O-des[2-aminoethyl]-O-carboxymethyl DH-AML (CM-DH-AML), and to use it for monitoring this drug in hypertensive patients. METHODS: Acetonitrile-deproteinized plasma specimens were separated using an octadecyl-silica column (3 µm particle size) with a mobile phase consisting of 50% methanol containing 0...
September 29, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28969447/beneficial-effects-of-a-probiotic-blend-on-gastrointestinal-side-effects-induced-by-leflunomide-and-amlodipine-in-a-rat-model
#5
S-C Song, Y-M An, J-H Shin, M-J Chung, J-G Seo, E Kim
Patients with metabolic disorders frequently suffer from side effects induced by long-term oral medications. The present study using a rat model system indicated that leflunomide (LF) and amlodipine (AMD), the active ingredients contained in the medications for rheumatoid arthritis and hypertension, respectively, appeared to induce various bowel problems including constipation and inflammation. In the small and large intestine, LF increased the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 compared to the null control and AMD increased the expression of both TNF-α and IL-1β, although its effect on IL-6 was only increased in the large intestine...
October 3, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28960482/a-randomized-controlled-study-evaluating-effects-of-amlodipine-addition-to-chelators-to-reduce-iron-loading-in-patients-with-thalassemia-major
#6
Aziz Eghbali, Hamideh Kazemi, Hassan Taherahmadi, Yazdan Ghandi, Mohammad Rafiei, Bahador Bagheri
AIM: Cardiomyopathy due to iron overload can be fatal in patients with thalassemia major. Calcium channel blockers seem to be effective to reduce iron loading. Our goal was to study effects of amlodipine addition to chelators on iron loading in patients with thalassemia major. METHODS: This randomized, controlled, and single-center trial was performed on 56 patients with thalassemia major. Patients were randomized 1:1 to combined group (iron chelator plus amlodipine) or control group (iron chelator) for 1 year...
September 27, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28957764/global-scanning-assessment-of-calcium-channel-blockers-in-the-environment-review-and-analysis-of-occurrence-ecotoxicology-and-hazards-in-aquatic-systems
#7
REVIEW
Gavin N Saari, W Casan Scott, Bryan W Brooks
As an urban water cycle is increasingly realized, aquatic systems are influenced by sewage and wastewater effluent discharges of variable quality. Such urbanization results in exposures of non-target aquatic organisms to medicines and other contaminants. In the present study, we performed a unique global hazard assessment of calcium channel blockers (CCB) in multiple environmental matrices. Effluent and freshwater observations were primarily from North America (62% and 76%, respectively) and Europe (21% and 10%, respectively) with limited-to-no information from rapidly urbanizing regions of developing countries in Asia-Pacific, South America, and Africa...
September 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28955416/monotherapy-with-amlodipine-or-hydrochlorothiazide-in-patients-with-mild-to-moderate-hypertension-comparison-of-their-efficacy-and-effects-on-electrolytes
#8
Daniel C Nwachukwu, Anthonius A Eze, Nkiru Z Nwachukwu, Eddy I Aneke, Polycarp U Agu, Nkiru C Azubike, Leonard Fo Obika, Onochie I Okoye
BACKGROUND: Amlodipine and hydrochlorothiazide (HCTZ) are commonly prescribed in Nigeria either as a monotherapy or in combination with other drugs. The present study was designed to investigate the antihypertensive efficacy of monotherapy with amlodipine or HCTZ and their effects on electrolyte profile in patients with mild to moderate hypertension. METHODS: A single-blind randomized clinical study was used; fifty patients newly diagnosed with mild to moderate hypertension (aged 33 to 60 years) were recruited and divided into two groups: amlodipine or hydrochlorothiazide each comprising of 25 subjects...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/28951665/prevalence-of-potential-drug-interactions-in-thai-patients-receiving-simvastatin-the-causality-assessment-of-musculoskeletal-adverse-events-induced-by-statin-interaction
#9
Methira Siriangkhawut, Patthana Tansakul, Verawan Uchaipichat
Drug-drug interactions are one of the major risk factors associated with statin-induced myopathy. Although simvastatin is widely used in Thailand, studies investigating the prevalence of potential simvastatin-drug interactions (SDIs) and its clinical relevance in Thai population are still limited. We aimed to investigate the prevalence of potential SDIs (phase 1 study) and musculoskeletal adverse effects (AEs) associated with those interactions (phase 2 study). A phase 1 study was retrospectively conducted with outpatients at a 60-bed hospital who received simvastatin between July 1, 2012 and June 30, 2013...
September 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28947617/treating-visit-to-visit-blood-pressure-variability-to-improve-prognosis-is-amlodipine-the-drug-of-choice
#10
REVIEW
Anastasios Kollias, George S Stergiou, Konstantinos G Kyriakoulis, Grzegorz Bilo, Gianfranco Parati
No abstract text is available yet for this article.
September 25, 2017: Hypertension
https://www.readbyqxmd.com/read/28945105/does-a-fixed-dose-combination-of-amlodipine-and-atorvastatin-improve-persistence-to-therapy-in-the-australian-population
#11
Louise E Bartlett, Nicole Pratt, Elizabeth E Roughead
AIM: To compare persistence in people who initiate the combination of amlodipine and statin as a fixed dose combination (FDC) or separate pill combination (SePC), and assess the impact of prior medicine exposure on this outcome. METHOD: Prescription dispensing data from a national administrative dataset were used to identify patients initiating FDCs or SePCs of amlodipine and statin between April and September 2013. Each cohort was stratified according to dispensing of calcium channel blockers (CCB) or statins in the prior 12 months...
September 25, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28939406/comparison-of-fixed-dose-combinations-of-amlodipine-losartan-potassium-chlorthalidone-and-amlodipine-losartan-potassium-in-patients-with-stage-2-hypertension-inadequately-controlled-with-amlodipine-losartan-potassium-a-randomized-double-blind-multicenter-phase
#12
Soon Jun Hong, Han Saem Jeong, Seung Hwan Han, Ki Yuk Chang, Bum Kee Hong, Bong Ki Lee, Shung Chull Chae, Woo Shik Kim, Chang Gyu Park, Jung Ho Heo, Seung Uk Lee, Young Dae Kim, Kee Sik Kim, Jung Hyun Choi, Hyun Jae Kang, Jae Joong Kim, Seok Min Kang, Young Jin Choi, Joon Han Shin, Kook Jin Chun, Dong Gu Shin, Seong Hoon Park, Jun Kwan, Yu Jeong Choi, Myung Ho Jeong, Jei Keon Chae, Dong Woon Kim, Jung Rae Cho, Kyoo Rok Han, Kyung Heon Won, Sang Ho Park, Sang Kon Lee, Sang Hoon Kim, Jina Jung, Cheol Ho Kim
PURPOSE: The goal of this study was to compare the efficacy and safety of fixed-dose combinations of amlodipine/losartan potassium/chlorthalidone (A/L/C) and A/L in Korean patients with stage 2 hypertension inadequately controlled by A/L. METHODS: This study was an 8-week, randomized double-blind, multicenter, phase III clinical trial. Three hundred forty volunteer patients with stage 2 hypertension were randomized to receive A/L/C or A/L. The primary end point was a change in sitting systolic blood pressure (SitSBP) after 8 weeks of treatment...
September 19, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28936150/prevalence-of-poor-glycemic-and-blood-pressure-control-and-pattern-of-drug-use-among-primary-health-care-outpatients-in-al-ahsa-saudi-arabia
#13
Promise M Emeka, Ahmed Al Mukalaf, Hussien Al Helal, Tahir M Khan, Mishial A Almukalf
OBJECTIVES: To assess drug use pattern and the effect on glycemic and blood pressure (BP) control in type 2 diabetes mellitus (T2DM) and hypertensive patients. Furthermore, to evaluate the duration of drug use and antecedence in diagnosis. METHODOLOGY: A cross-sectional study design, comprising interview/questionnaire targeting outpatients attending primary health centers in Al Ahsa was adopted. During the interview, their fasting blood glucose, weight, and height were measured, along with their BP...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28914848/-effect-of-a-fixed-dose-combination-of-perindopril-arginine-amlodipine-on-the-level-and-variability-of-blood-pressure-according-to-its-office-visit-to-visit-measurements-and-self-measurements-at-home-a-subanalysis-of-the-prevoshodstvo-superiority-program
#14
O D Ostroumova
AIM: To study the effect of a fixed-dose combination of perindopril arginine/amlodipine (prestans) on the goal levels and variability of blood pressure (BP) according to its office visit-to-visit measurements and self-measurement (OVVM and SM) in a subgroup of 483 people from the population of the Russian observational SUPERIORITY program, most cases of whom are given the combination replacing the previously ineffective mono- and combination antihypertensive therapy (AHT). SUBJECTS AND METHODS: The subanalysis included data on 483 patients (34% men) aged 57...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914847/-efficiency-of-triple-antihypertensive-therapy-in-patients-with-uncontrolled-hypertension-and-depressive-disorders
#15
V V Skibitsky, A V Fendrikova, A V Skibitsky
AIM: To evaluate the efficiency of triple antihypertensive therapy in patients with uncontrolled hypertension and depressive disorders (DD). MATERIAL AND METHODS: 153 patients with uncontrolled hypertension were examined, of whom 82 patients were diagnosed with mild and moderate DD. A combination of perindopril 10 mg/day, indapamide SR 1.5 mg/day, and amlodipine at an initial dose of 5 mg/day was given to patients with hypertension and DD. After 4 weeks of treatment, if target blood pressure (BP) levels could not be achieved, the dose of amlodipine was increased up to 10 mg/day...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28904053/cardiovascular-biomarkers-in-hypertensive-patients-with-medical-treatment-results-from-the-randomized-teamsta-protect-i-trial
#16
Annika Jagodzinski, Johannes Tobias Neumann, Francisco Ojeda, Nils Arne Sörensen, Philipp Wild, Thomas Münzel, Tanja Zeller, Dirk Westermann, Stefan Blankenberg
BACKGROUND: High blood pressure (BP) is associated with an increased rate of cardiovascular events and mortality. Cardiovascular biomarkers are able to predict long-term risk in the general population, particularly in diseased cohorts. We undertook an investigation of the effect of 2 different antihypertensive treatments on cardiovascular biomarkers in a randomized trial. METHODS: The TEAMSTA study included 481 hypertensive patients. They were randomized to either 80-mg telmisartan + 5-mg amlodipine (TA) or 40-mg olmesartan + 12...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28901251/case-report-severe-hematological-muscle-and-liver-toxicity-caused-by-drugs-and-artichoke-infusion-interaction-in-an-elderly-polymedicated-patient
#17
M G Campos, J Machado, M L Costa, S Lino, F Correia, F Maltez
Case report, in a patient with a history of diabetes and hypertension, treated with metformin, gliclazide, enalapril + hydrochlorothiazide, amlodipine, aspirin and diazepam, recently medicated for a gouty crisis with colchicine and clonixin without improvement. Believing it could help in the treatment of gouty crisis symptoms he took about 1.5 L of artichoke infusion (Cynara cardunculus). He felt better and did agriculture work but developed a distal muscle pain, severe anemia, standard biochemical liver cholestasis, increase of alkaline phosphatase and marked increase of inflammatory parameters (hyperleucocytosis) and enters in the emergency department at the hospital...
September 12, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28892318/-lipertance%C3%A2-the-ascot-single-pill-combination-has-finally-arrived
#18
REVIEW
R P Radermecker
The fixed association of atorvastatin, perindopril and amlodipine was recently launched by the firm SERVIER under the name of Lipertance®. It is the first fixed association of a statin, an ACE inhibitor and a calcium blocker present on the Belgian market to handle the risk factors that are hypertension and dyslipidemia which can be used both in primary and secondary cardiovascular prevention. The interests of such a triple combined therapy are many in terms of morbimortality reduction, as observed in ASCOT trial...
September 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28888975/solvent-responsive-floating-liquid-crystalline-molecularly-imprinted-polymers-for-gastroretentive-controlled-drug-release-system
#19
Li-Ping Zhang, Xiao-Lin Wang, Qian-Qian Pang, Yan-Ping Huang, Lei Tang, Meng Chen, Zhao-Sheng Liu
Liquid crystalline-molecularly imprinted polymer (LC-MIP) particles were first found to possess the floating behavior on the aqueous medium. Combined with molecular recognition, the LC-MIP was fabricated as a novel class of the controlled-release gastric retentive DDS. The LC-MIP was made using co-polymerization of methacrylic acid, 4-methyl phenyl dicyclohexyl ethylene (LC monomer with vinyl group), and ethylene glycol dimethacrylate with S-amlodipine (S-AML) as model template drug. The optimum condition of the preparation of LC-MIP has been obtained relying on release behaviors of S-AML from the LC-MIP...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28886992/study-on-the-effect-of-irbesartan-on-atrial-fibrillation-recurrence-in-kumamoto-atrial-fibrillation-suppression-trial-silk-study
#20
Hiroshige Yamabe, Koichi Kaikita, Toshiyuki Matsumura, Atsushi Iwasa, Junjiro Koyama, Takashi Uemura, Yasuhiro Morikami, Ryusuke Tsunoda, Kenji Morihisa, Kazuteru Fujimoto, Ichiro Kajiwara, Kunihiko Matsui, Kenichi Tsujita, Hisao Ogawa
BACKGROUND: Experimental studies suggest that angiotensin II-receptor blockers can influence atrial remodeling and may prevent atrial fibrillation (AF). Therefore, we hypothesized that irbesartan may prevent the recurrence of AF following either catheter ablation or electrical cardioversion of AF. METHODS: Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto (SILK study) is a prospective, multicenter, randomized, and open-label comparative evaluation of the effects of irbesartan and amlodipine on AF recurrence in hypertensive patients with AF who are scheduled to undergo catheter ablation or electrical cardioversion of AF...
September 5, 2017: Journal of Cardiology
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