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https://www.readbyqxmd.com/read/28822166/-clinical-observation-of-modified-da-chaihu-decoction-in-treating-essential-hypertension-with-anxiety
#1
Xiang-Dong Zhang, Wang-Qiang Cheng, Yong-Gang Wang, Zheng Zhang
To observe the clinical efficacy of modified Da Chaihu decoction in treating essential hypertension with anxiety, the randomized, controlled, clinical trial was performed in this study. One hundred and twenty-six hypertensive patients with anxiety meeting the inclusive criteria were randomized into the treatment group and the control group. All of the included patients in the above 2 groups were treated by amlodipine besylate tablets. Patients in the treatment group were given Chinese herbal medicine modified Da Chaihu decoction every day...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28816547/drug-utilization-among-hypertensive-patients-in-the-outpatient-department-of-medicine-in-a-tertiary-care-hospital-a-cross-sectional-study
#2
Sarika G Paradkar, Shyamal R Sinha
BACKGROUND: Hypertension is one of the leading risk factors for cardiovascular, cerebrovascular, and renal disease. Its increasing prevalence and treatment costs influence the prescribing pattern among physicians. Drug utilization studies provide insights into the current prescribing practices and help us facilitate the rational use of drugs. We carried out the present study to assess the pattern of drug utilization in hypertensive patients. METHOD: Adults seeking treatment for hypertension were recruited...
August 17, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28805468/long-term-persistence-with-single-pill-fixed-dose-combination-therapy-versus-two-pills-of-amlodipine-and-perindopril-for-hypertension-australian-experience
#3
Leon A Simons, Eric Chung, Michael Ortiz
OBJECTIVE: To study treatment persistence and mortality using a single-pill, fixed-dose combination tablet compared with a two-pill combination for hypertension. RESEARCH DESIGN AND METHODS: We analyzed Australian Pharmaceutical Benefit Scheme records 2011-2014 in a 10% random sample of concessional patients prescribed concomitant amlodipine and perindopril - either as a single-pill, fixed-dose combination tablet (n = 9340) or as two-pill combination therapy (n = 3093)...
August 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28768527/bilateral-blindness-secondary-to-optic-nerve-ischemia-from-severe-amlodipine-overdose-a-case-report
#4
Raymond Kao, Yves Landry, Genevieve Chick, Andrew Leung
BACKGROUND: Calcium channel blockers are commonly prescribed medications; calcium channel blocker overdose is becoming increasingly prevalent. The typical presentation of a calcium channel blocker overdose is hypotension and decreased level of consciousness. We describe a case of a calcium channel blocker overdose that led to bilateral cortical blindness, a presentation that has not previously been reported. CASE PRESENTATION: A 49-year-old white woman with known bilateral early optic atrophy presented to our hospital with hypotension and obtundation following a known ingestion of 150 mg of amlodipine...
August 3, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28766181/treatment-of-amlodipine-intoxication-with-intravenous-lipid-emulsion-therapy-a-case-report-and-review-of-the-literature
#5
REVIEW
Funda Karbek Akarca, Ece Akceylan, Selahattin Kıyan
We report the case of a 25-year-old female presenting to the emergency department after committing suicide by ingesting 100 mg amlodipine. The patient was initially treated with intravenous fluids, calcium gluconate, catecholamines and glucagone without effect. The clinical condition of the patient improved quickly and dramatically on the 20th minute of intravenous lipid emulsion (ILE) therapy. Different treatment methods have been developed for calcium channel blocker intoxication over the last years. Among these, lipid emulsion therapy has risen over the last decade as a salvation in cases which do not respond to other treatments...
August 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28764190/comparison-of-plasma-levels-of-renin-vasopressin-and-atrial-natriuretic-peptide-in-hypertensive-amlodipine-induced-pedal-oedema-non-oedema-and-cilnidipine-treated-patients
#6
Kiran Shetty, Ranjan Shetty, Pragna Rao, Mamatha Ballal, Amruth Kiran, Sravan Reddy, Umesh Pai, Jyothi Samanth
INTRODUCTION: Amlodipine is a third generation dihydropyridine group of calcium channel blocker and having an excellent antihypertensive profile. Pedal Oedema (PE) is the major drawback of amlodipine therapy and the incidence of Amlodipine Induced Pedal Oedema (AIPE) has been found significantly high. Several neurohumoral factors influence the incidence of oedema. AIM: We aimed to compare the plasma levels of renin, vasopressin and atrial natriuretic peptide in hypertensive AIPE, non-oedema and cilnidipine treated patients...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762933/-optimization-of-bp-control-and-arterial-elasticity-with-fixed-combination-therapy-perindopril-and-amlodipine-in-patients-with-arterial-hypertension-and-increased-pulse-wave-velocity
#7
S V Nedogoda, A O Konradi, N E Zvartau, E V Chumachek, A A Ledyaeva, V V Tsoma, A S Salasyuk, J S Judina, V O Smirnova, V J Khripaeva, R V Palashkin
The aim of the study was to assess the possibility of fixed combination perindopril+amlodipine to improve arterial elesticity in patients with hypertension and high pulse wave velocity, despite previous combination antihypertensive therapy. In an open, multicenter, observational study duration of 24 weeks 80 patients were included, divided into 4 equal-sized groups, depending on initial antihypertensive therapy: Group 1 - the combination of ACE inhibitor and diuretic, Group 2 - the combination of ACE inhibitor and calcium channel blocker, Group 3 - the combination of diuretic and angiotensin receptor blocker, Group 4 - the combination of angiotensin receptor blocker and calcium antagonist...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28762910/-fixed-drug-combination-amlodipine-indapamide-and-perindopril-new-horizons-of-antihypertensive-therapy
#8
Zh Kobalava, E Troitskaya, N Ezhova
High prevalence of arterial hypertension and low rate of blood pressure (BP) control in patients with arterial hypertension require more intensive approaches to antihypertensive therapy. Every patient with arterial hypertension is characterized by different predominant pathophysiologic mechanisms in different periods of his life. Because of impact on different pathophysiologic mechanisms combined antihypertensive therapy allows to achieve more pronounced BP reduction, decrease heterogeneity of response and alleviate side effects of each component...
April 2017: Kardiologiia
https://www.readbyqxmd.com/read/28760606/synthesis-analytical-characterization-and-capillary-electrophoretic-use-of-the-single-isomer-heptakis-6-o-sulfobutyl-beta-cyclodextrin
#9
Milo Malanga, Ida Fejős, Erzsébet Varga, Gábor Benkovics, András Darcsi, Julianna Szemán, Szabolcs Béni
This contribution reports the synthesis, characterization and capillary electrophoretic application of heptakis-(6-O-sulfobutyl-ether)-β-cyclodextrin sodium salt, (6-(SB)7-β-CD). The compound was obtained through a five-steps synthesis and it represents the first example of single-isomer sulfobutylated cyclodextrin that carries the negatively charged functions exclusively on its primary side and it is unmodified on the lower rim. The purity of each intermediate was determined by appropriate liquid chromatographic methods, while the isomeric purity of the final product was established by an ad-hoc developed HPLC method based on a CD-Screen-IEC column...
July 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28750296/the-role-of-l-type-calcium-channels-in-mouse-oocyte-maturation-activation-and-early-embryonic-development
#10
Gui-Fang He, Lei-Lei Yang, Shi-Ming Luo, Jun-Yu Ma, Zhao-Jia Ge, Wei Shen, Shen Yin, Qing-Yuan Sun
Calcium ion fluctuation is closely related to the transformation of cell cycle. However, little is known about the function of L-type calcium channel in mammalian oocyte and embryo development. We thus studied the roles of L-type calcium channel in mouse oocyte meiotic maturation, parthenogenetic activation and early embryonic development. We used the antagonist Amlodipine to block L-type calcium channel. Oocytes or zygotes were cultured to different time points with 0 μM, 10 μM, 30 μM and 50 μM Amlodipine...
July 18, 2017: Theriogenology
https://www.readbyqxmd.com/read/28734660/efficacy-and-tolerability-of-combination-therapy-versus-monotherapy-with-candesartan-and-or-amlodipine-for-dose-finding-in-essential-hypertension-a-phase-ii-multicenter-randomized-double-blind-clinical-trial
#11
Il Suk Sohn, Chong-Jin Kim, Taehoon Ahn, Ho-Joong Youn, Hui-Kyung Jeon, Sang Hyun Ihm, Eun Joo Cho, Woo-Baek Chung, Shung Chull Chae, Woo-Shik Kim, Chang-Wook Nam, Seong-Mi Park, Ji-Yong Choi, Young-Kwon Kim, Taek-Jong Hong, Hae-Young Lee, Jang-Hyun Cho, Eun-Seok Shin, Jung-Han Yoon, Tae-Hyun Yang, Myung-Ho Jeong, Jun-Hee Lee, Joong-Il Park
PURPOSE: Intensive blood pressure (BP) lowering is important for the treatment of hypertension; however, it has been a challenge to achieve target BP in many patients. The purpose of this study was to explore the optimal dosage of a fixed-dose combination of candesartan cilexetil (CAN) and amlodipine besylate (AML), by examining the tolerability and efficacy of CAN/AML combination therapy compared with those of monotherapy with either drug in patients with essential hypertension. METHODS: This Phase II multicenter, randomized, double-blind clinical trial enrolled patients aged 19 years or older with essential hypertension, defined as a mean sitting diastolic BP (msDBP) between 95 and 115 mm Hg, and a mean sitting systolic BP (msSBP) of <200 mm Hg after a 2-week placebo run-in period...
July 19, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28729910/drug-induced-gingival-hyperplasia-a-retrospective-study-using-spontaneous-reporting-system-databases
#12
Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada, Mitsuhiro Nakamura
BACKGROUND: Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases. METHODS: We analyzed reports of DIGH from SRS databases and calculated the reporting odds ratios (RORs) of suspected drugs (immunosuppressants, calcium channel blockers, and anticonvulsants)...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28721700/blood-pressure-lowering-efficacy-of-indapamide-sr-amlodipine-combination-in-older-patients-with-hypertension-a-post-hoc-analysis-of-the-nestor-trial-natrilix-sr-vs-enalapril-in-hypertensive-type-2-diabetics-with-microalbuminuria
#13
Olivier Hanon, Laure Caillard, Edouard Chaussade, Intza Hernandorena, Clemence Boully
To examine the antihypertensive efficacy and safety of indapamide sustained-release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted. NESTOR randomized 570 patients (n=197, aged ≥65 years) with hypertension (systolic BP 140-180/diastolic BP <110 mm Hg) to indapamide SR 1.5 mg or enalapril 10 mg...
July 18, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28721143/the-effect-of-antihypertensive-treatment-on-arterial-stiffness-and-serum-concentration-of-selected-matrix-metalloproteinases
#14
Marek Rajzer, Wiktoria Wojciechowska, Tomasz Kameczura, Agnieszka Olszanecka, Danuta Fedak, Michał Terlecki, Kalina Kawecka-Jaszcz, Danuta Czarnecka
INTRODUCTION: The aim of the study was to assess the arterial stiffness and serum levels of selected metalloproteinases (MMPs) in hypertensive patients and their changes following antihypertensive therapy. MATERIAL AND METHODS: The study group consisted of 95 patients with essential arterial hypertension (HT) stage 1 or 2 (mean age: 53.1 ±13.0 years). The control group consisted of 31 normotensives of the same age range. Hypertension patients were randomized to one of the following monotherapies for 6 months: quinapril, losartan, amlodipine, hydrochlorothiazide or bisoprolol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721135/a-comprehensive-guidelines-based-approach-reduces-cardiovascular-risk-in-everyday-practice-the-varo-study
#15
Tomáš Štulc, Věra Lánská, Michaela Šnejdrlová, Michal Vrablík, Martina Prusíková, Richard Češka
INTRODUCTION: The aim of study was to investigate the possibility of cardiovascular risk improvement through systematic identification of high-risk individuals and treatment in accordance with current guidelines using modern therapy in daily clinical practice. MATERIAL AND METHODS: Two hundred and sixty-three physicians participated in the study. The physicians were asked to screen for cardiovascular risk factors in patients presenting with unrelated problems and to re-evaluate the attainment of treatment goals in those with already known risk factors...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28716880/teaching-neuroimages-amlodipine-responsive-trigeminal-neuralgia-an-alibi-for-vascular-compression-theory
#16
Ravi Uniyal, Vimal Kumar Paliwal, Neeraj Kumar, Hardeep Singh Malhotra, Ravindra Kumar Garg, Zafar Neyaz
No abstract text is available yet for this article.
July 18, 2017: Neurology
https://www.readbyqxmd.com/read/28692311/prospective-direct-comparison-of-antihypertensive-effect-and-safety-between-high-dose-amlodipine-or-indapamide-in-hypertensive-patients-uncontrolled-by-standard-doses-of-angiotensin-receptor-blockers-and-amlodipine
#17
Keisuke Okamura, Kazuyuki Shirai, Nao Totake, Tetsu Okuda, Hidenori Urata
OBJECTIVE: When hypertension is uncontrolled by routine treatment with an angiotensin II receptor blocker (ARB) and the calcium channel blocker amlodipine (5 mg), the dose of amlodipine can be increased or a diuretic can be added. We investigated the more effective option in a prospective multicenter open-label study. METHODS: Hypertensive patients were recruited if the target blood pressure (BP) in The Japanese Society of Hypertension 2009 guideline could not be achieved with standard-dose ARB therapy and amlodipine (5 mg)...
July 10, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28688059/a-case-of-severe-refractory-hypotension-after-amlodipine-overdose
#18
Melissa Chudow, Kevin Ferguson
Calcium channel blockers (CCBs) are responsible for a substantial portion of the mortality associated with cardiovascular medication overdose cases. Amlodipine, a dihydropyridine CCB, can cause prolonged hypotension in overdose. This report describes a severe amlodipine overdose case that was refractory to multiple therapeutic approaches. A 53-year-old male presented after ingesting eighty 10 mg amlodipine tablets in a suicide attempt. The patient was initially managed with calcium boluses, glucagon, multiple vasoactive agents, lipid emulsion infusions and hyperinsulinemic euglycemic therapy...
July 7, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28687552/hyponatremia-induced-by-hyperinsulinemia-euglycemia-therapy
#19
Jennifer R Beavers, Joanna L Stollings, Todd W Rice
PURPOSE: A case of symptomatic hyponatremia induced by hyperinsulinemia-euglycemia (HIE) therapy is reported. SUMMARY: A 59-year-old, 81.65-kg woman with hypertension, major depressive disorder, and anxiety arrived at a tertiary medical center 1.5 hours after an intentional overdose of oral amlodipine 200 mg, metoprolol tartrate 2,000 mg, and isosorbide mononitrate 1,200 mg. Upon arrival, her pulse was 63 beats/min and blood pressure was 106/56 mm Hg. The patient's blood pressure was refractory to fluids, calcium gluconate, and norepinephrine, resulting in initiation of HIE therapy...
July 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28676728/-olmesartan-associated-enteropathy-attention-to-an-emerging-iatrogenic-phenomenon
#20
J L Modesto Dos Santos, P González Recio, O A Terry López, I Leturia Frade, B Aguiar Losada, J I Elejalde Guerra
Olmesartan is an angiotensin II type 1 receptor blocker commonly used in the treatment of hypertension. Several cases of sprue-like enteropathy associated with the use of this drug have been described which, even with important signs and limitations for the patient, present a full recovery after discontinuing the use of olmesartan. The case of a 64 year-old patient is presented, diagnosed with hypertension, under treatment with olmesartan-amlodipine, with chronic diarrhoea and villous atrophy on intestinal biopsies without diagnostic criteria for celiac disease and with complete remission after suspending discontinuing the use of olmesartan...
July 4, 2017: Anales del Sistema Sanitario de Navarra
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