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https://www.readbyqxmd.com/read/28804599/circulating-exosome-microrna-associated-with-heart-failure-secondary-to-myxomatous-mitral-valve-disease-in-a-naturally-occurring-canine-model
#1
Vicky K Yang, Kerry A Loughran, Dawn M Meola, Christine M Juhr, Kristen E Thane, Airiel M Davis, Andrew M Hoffman
Myxomatous mitral valve disease (MMVD) is functionally and histologically identical to mitral valve prolapse (MVP) in humans. Currently, there are no medical treatments that can delay the progression of this valvular disease or associated cardiac remodelling. Therefore, there is a need to understand the molecular pathology associated with MMVD and MVP better, and thus identify potential therapeutic targets. Circulating exosomes contain small RNA, including miRNA, which reflect cell physiology and pathology...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28795781/evaluation-of-the-use-of-shock-index-in-identifying-acute-blood-loss-in-healthy-blood-donor-dogs
#2
Erin E McGowan, Kimberly Marryott, Kenneth J Drobatz, Erica L Reineke
OBJECTIVE: To determine if shock index (SI) would increase following blood donation and if it would be a more sensitive assessment of acute blood loss as compared with heart rate (HR), blood pressure, and plasma lactate. DESIGN: Prospective study. SETTING: University teaching hospital. ANIMALS: Twenty client-owned clinically normal dogs. INTERVENTIONS: Peripheral venous blood measurements and blood donation...
August 10, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28770713/detection-and-multilocus-genotyping-of-giardia-duodenalis-in-dogs-in-sichuan-province-china
#3
Yue Zhang, Zhijun Zhong, Lei Deng, Maoqing Wang, Wei Li, Chao Gong, Hualin Fu, Suizhong Cao, Xianpeng Shi, Kongju Wu, Guangneng Peng
Giardia duodenalis (also known as G. intestinalis) is a flagellated protozoan that parasitizes the small intestine and is a common causal agent of zoonotic infections in humans and animals. To assess the genetic diversity and zoonotic transmission potential of G. duodenalis in stray dogs, 159 fecal specimens were collected from dogs in Chengdu, Yaan, and Leshan in Sichuan province, China. Of the 159 fecal samples from stray dogs, 18 (11.3%) were G. duodenalis-positive based on nested PCR amplification of the beta giardin (bg) gene, and the occurrence varied from 1...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28770578/detection-of-ige-reactive-proteins-in-hydrolysed-dog-foods
#4
Olivier Roitel, Lionel Bonnard, Alexandre Stella, Odile Schiltz, Delphine Maurice, Gaël Douchin, Sandrine Jacquenet, Claude Favrot, Bernard E Bihain, Nicolas Couturier
BACKGROUND: Commercial hydrolysed diets are used for the diagnosis of food allergy in dogs. The cleaved parent proteins are presumed to be too small to elicit an allergic response by reacting with allergen-specific immunoglobin E (IgE). OBJECTIVES: To evaluate three commercial hydrolysed dog diets for proteins. ANIMALS: Sera were collected from dogs with suspected food allergy. METHODS: Two batches of each hydrolysed diet were examined by electrophoresis and visualized by Coomassie blue, silver nitrate staining and IgE immunoblotting...
August 2, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28763525/prevalence-treatment-and-outcome-of-patellar-luxation-in-dogs-in-italy-a-retrospective-multicentric-study-2009-2014
#5
Francesca Bosio, Antonello Bufalari, Bruno Peirone, Massimo Petazzoni, Aldo Vezzoni
OBJECTIVE: To determine the prevalence of patellar luxation in dogs in Italy and its relation to signalment, the frequency and the type of postoperative complications and the outcome of treatment, and to compare the findings with those of other studies. MATERIALS AND METHODS: The medical records from four referral clinics were searched for dogs with orthopaedic disorders referred from 2009 to 2014. From these data, the records of dogs with patellar luxation were identified, and the signalment, age and body weight, grade, side and direction of patellar luxation, treatment, postoperative complications, and outcome were retrieved...
August 1, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28761666/radial-and-ulnar-fracture-treatment-with-paraosseous-clamp-cerclage-stabilisation-technique-in-17-toy-breed-dogs
#6
George Manchi, Mathias M Brunnberg, Muhammad Shahid, Ahmad Al Aiyan, Eric Chow, Leo Brunnberg, Silke Stein
OBJECTIVE: Description of surgical technique, complications and outcome of radius/ulna fractures in toy and miniature breed dogs treated with the paraosseous clamp-cerclage stabilisation (PCCS) method. STUDY DESIGN: Retrospective study. METHODS: Clinical records of small breed dogs with fractures of the radius and ulna were reviewed between January 2011 and January 2016. Inclusion criteria were bodyweight of ≤3.5 kg, fracture of the radius and ulna of one or two limbs without previous repair attempts, available follow-up information, and the use of PCCS for repair of the fracture as the sole method of fixation...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28761194/spontaneous-resorption-of-a-herniated-cervical-disc-in-a-dog-detected-by-magnetic-resonance-imaging
#7
Francesca Raimondi, Beatriz Moreno-Aguado, Phil Witte, Nadia Shihab
This report describes, for the first time in small animal literature, the spontaneous resorption of herniated Hansen type I intervertebral disc material in the cervical spine of a chondrodystrophic dog over a 4-month period, documented by magnetic resonance imaging. Clinical signs (cervical hyperpathia) responded to conservative treatment during the same period.
August 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28761184/agreement-among-undergraduate-and-graduate-veterinary-students-and-veterinary-anesthesiologists-on-pain-assessment-in-cats-and-dogs-a-preliminary-study
#8
Graeme M Doodnaught, Javier Benito, Beatriz P Monteiro, Guy Beauchamp, Stefania C Grasso, Paulo V Steagall
This study investigated agreement among undergraduate and graduate veterinary students and veterinary anesthesiologists on video pain assessment at the University of Montreal. Pain assessment in dogs and cats appeared to be affected by gender, previous experience, and degree of training despite a small population of observers.
August 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28759770/downward-dog-becomes-fit-body-inc-a-content-analysis-of-40-years-of-female-cover-images-of-yoga-journal
#9
Jennifer B Webb, Erin R Vinoski, Jan Warren-Findlow, Marlene I Burrell, Davina Y Putz
The present analysis investigated temporal trends in physical appearance attributes and attire worn by female cover models of Yoga Journal magazine between the years 1975-2015. Covers featuring a single female model (N=168) were coded for: pose activity, amount of body visibility, perceived body size, body shape, breast size, skin exposure, and revealing or form-fitting attire. When collapsed across all decades, the majority of cover models was actively posed with high body visibility, rated as at most low normal weight, possessed either a "thin/lean" or "skinny/boney" body shape, and were "flat-chested" or "small-breasted"...
July 28, 2017: Body Image
https://www.readbyqxmd.com/read/28759118/mandibular-body-fracture-repair-with-wire-reinforced-interdental-composite-splint-in-small-dogs
#10
Michel Guzu, Philippe R Hennet
OBJECTIVE: To report the outcome of mandibular body fractures treated with a wire-reinforced interdental composite splint (WRICS) in small breed dogs. STUDY DESIGN: Retrospective case series. ANIMALS: Client-owned small breed dogs (n = 24). METHODS: Medical records (1998-2012) of small breed dogs (<10 kg) with mandibular body fractures treated by WRICS were reviewed for signalment, history, type of fracture, treatment, and clinical and radiological follow-up...
July 31, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28757523/operative-techniques-of-percutaneous-endoscopic-mini-hemilaminectomy-using-a-uniportal-approach-in-dogs
#11
Hee-Sup Moon, Yong-Hyun Hwang, Hee-Chun Lee, Jae-Hoon Lee
The present study aimed to investigate the technical feasibility of percutaneous endoscopic mini-hemilaminectomy via a uniportal approach, and to evaluate the possibility of decompression and endoscopic examination of the thoracic and lumbar spinal canals in small dogs during such procedures. Fresh canine cadavers of mixed-breed dogs (n=7) were used in this study. Following injection of a barium and agarose mixture (BA-gel) to stimulate intervertebral disc herniation, percutaneous endoscopic mini-hemilaminectomy was performed using a lateral approach to the thoracic and lumbar vertebrae...
July 31, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28757521/retrospective-investigation-of-cardiopulmonary-resuscitation-outcome-in-146-exotic-animals
#12
Mamoru Onuma, Hirotaka Kondo, Sadaharu Ono, Akiyoshi Murakami, Tomoko Harada, Tadashi Sano
The outcomes of cardiopulmonary resuscitation (CPR) were retrospectively evaluated in 146 exotic animals including 20 pet birds, 47 rabbits, 34 hamsters, 18 ferrets, 7 turtles, and 20 other small mammals in cardiopulmonary arrest (CPA) at presentation or during hospitalization at an animal clinic. The rates of return of spontaneous circulation, survival after CPR, and discharge were 9.3%, 2.3%, and 1.2%, respectively. The mean success rate of CPR in animals included in this study was lower than those previously reported in dogs and cats...
July 28, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28756976/oncocytic-papillary-cystadenoma-with-prominent-mucinous-differentiation-of-parotid-gland-a-case-report
#13
Borislav A Alexiev, Lawrence J Jennings, Sandeep Samant, Sambasiva Rao
We describe the case of an oncocytic papillary cystadenoma with mucinous differentiation of the parotid gland in a 64-year-old male. Histologically, the tumor exhibited distinctive areas of intracystic papillary growth pattern with microcystic and macrocystic spaces containing mucinous secretions and small crystals. The cyst wall and papillary fronds were lined by oncocytic admixed with numerous mucocytes. Lymphoid tissue and invasive features were not identified. The tumor showed strong expression of CK7 and mammaglobin in oncocytes, and BRST-2 and MUC4 in mucocytes...
July 8, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28755272/polymorphism-and-methylation-of-the-mc4r-gene-in-obese-and-non-obese-dogs
#14
Monika Mankowska, Joanna Nowacka-Woszuk, Aneta Graczyk, Paulina Ciazynska, Monika Stachowiak, Marek Switonski
The dog is considered to be a useful biomedical model for human diseases and disorders, including obesity. One of the numerous genes associated with human polygenic obesity is MC4R, encoding the melanocortin 4 receptor. The aim of our study was to analyze polymorphisms and methylation of the canine MC4R in relation to adiposity. Altogether 270 dogs representing four breeds predisposed to obesity: Labrador Retriever (n = 187), Golden Retriever (n = 38), Beagle (n = 28) and Cocker Spaniel (n = 17), were studied...
July 28, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28754076/immunologic-detection-of-giardia-duodenalis-in-a-specific-pathogen-free-captive-olive-baboon-papio-cynocephalus-anubis-colony
#15
Meriam N Saleh, Jennifer E Thomas, Jack R Heptinstall, Joel F Herbein, Roman F Wolf, Mason V Reichard, Anne M Zajac
Several commercial Giardia immunoassays were evaluated in baboons for sensitivity and specificity as well as ease of use in a large specific pathogen-free (SPF) colony. An additional objective was to identify the assemblage(s) of Giardia duodenalis present in this baboon colony. A direct immunofluorescent antibody test (IFAT) was used as the reference test. Tests evaluated were a patient-side rapid test for dogs and cats, a human rapid test, and a well-plate ELISA designed for use with humans. Test sensitivities and specificities were compared using the McNemar paired t-test and were further evaluated for agreement using an unweighted Cohen kappa statistic...
July 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28752521/effect-of-catheter-size-and-injection-rate-of-contrast-agent-on-enhancement-and-image-quality-for-triple-phase-helical-computed-tomography-of-the-liver-in-small-dogs
#16
Sang-Kwon Lee, Dahae Lee, Dongeun Kim, Ahyoung Cha, Jihye Choi
Rapid contrast injection is recommended for triple-phase helical computed tomography (CT) of the liver. However, a large-gauge catheter is needed for faster contrast injection and this is not practical for small breed dogs or cats. The purpose of this crossover group study was to evaluate applicability of a lower injection rate with a small-gauge (G) catheter for triple-phase hepatic CT in small dogs. Triple-phase CT images were acquired for six beagle dogs using three protocols: an injection rate of 1.5 ml/s with a 24 G catheter, 3...
July 27, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28750788/autologous-platelet-concentrates-as-treatment-for-avascular-necrosis-of-femoral-head-in-a-dog
#17
Estefanía Parra, Andrea Vergara, Raúl F Silva
Avascular necrosis of the femoral head is a developmental disturbance that generally affects young dogs of small breeds and produces ischemic necrosis of the femoral head resulting in an incongruous and malformed joint. The most common treatment is the excisional arthroplasty of the head and femoral neck. The aim of this study is to describe the treatment of avascular necrosis in a Yorkshire dog using intra-articular injections of autologous platelet concentrate. Evaluations were made at 0, 15, 30, 60, and 120 days of treatment, describing the following parameters: clinical gait analysis, perimetry, goniometry, and radiographic evaluations...
March 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28750090/target-specificity-in-vivo-pharmacokinetics-and-efficacy-of-the-putative-stat3-inhibitor-ly5-in-osteosarcoma-ewing-s-sarcoma-and-rhabdomyosarcoma
#18
Peter Y Yu, Heather L Gardner, Ryan Roberts, Hakan Cam, Seethalakshmi Hariharan, Ling Ren, Amy K LeBlanc, Hui Xiao, Jiayuh Lin, Denis C Guttridge, Xiaokui Mo, Chad E Bennett, Christopher C Coss, Yonghua Ling, Mitch A Phelps, Peter Houghton, Cheryl A London
BACKGROUND: STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting metastasis and chemotherapy resistance. The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5. METHODS AND FINDINGS: An in silico fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization...
2017: PloS One
https://www.readbyqxmd.com/read/28738005/accuracy-and-repeatability-of-long-bone-replicas-of-small-animals-fabricated-by-use-of-low-end-and-high-end-commercial-three-dimensional-printers
#19
Jamie A Cone, Thomas M Martin, Denis J Marcellin-Little, Ola L A Harrysson, Emily H Griffith
OBJECTIVE To assess the repeatability and accuracy of polymer replicas of small, medium, and large long bones of small animals fabricated by use of 2 low-end and 2 high-end 3-D printers. SAMPLE Polymer replicas of a cat femur, dog radius, and dog tibia were fabricated in triplicate by use of each of four 3-D printing methods. PROCEDURES 3-D renderings of the 3 bones reconstructed from CT images were prepared, and length, width of the proximal aspect, and width of the distal aspect of each CT image were measured in triplicate...
August 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28737247/a-single-base-deletion-in-the-slc45a2-gene-in-a-bullmastiff-with-oculocutaneous-albinism
#20
M Caduff, A Bauer, V Jagannathan, T Leeb
Oculocutaneous albinism type 4 (OCA4) in humans and similar phenotypes in many animal species are caused by variants in the SLC45A2 gene, encoding a putative sugar transporter. In dog, two independent SLC45A2 variants are known that cause oculocutaneous albinism in Doberman Pinschers and several small dog breeds respectively. For the present study, we investigated a Bullmastiff with oculocutaneous albinism. The affected dog was highly inbred and resulted from the mating of a sire to its own grandmother. We obtained whole genome sequence data from the affected dog and searched specifically for variants in candidate genes known to cause albinism...
July 24, 2017: Animal Genetics
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