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https://www.readbyqxmd.com/read/28532340/ileocolic-junction-resection-in-dogs-and-cats-18-cases
#1
Yordan Fernandez, Mayank Seth, Daniela Murgia, Jordi Puig
There is limited veterinary literature about dogs or cats with ileocolic junction resection and its long-term follow-up. To evaluate the long-term outcome in a cohort of dogs and cats that underwent resection of the ileocolic junction without extensive (≥50%) small or large bowel resection. Medical records of dogs and cats that had the ileocolic junction resected were reviewed. Follow-up information was obtained either by telephone interview or e-mail correspondence with the referring veterinary surgeons...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28529274/pleomorphic-adenoma-of-the-labial-gland-characterized-by-reticular-pattern-of-myoepithelial-cells-in-a-dog
#2
Mizuki Kuramochi, Takeshi Izawa, Shin Nishimura, Terumasa Shimada, Mitsuru Kuwamura, Jyoji Yamate
An 11-year-old female golden retriever dog had a mass at the right corner of the upper lip, which gradually increased in size and protruded into the oral cavity. The mass was removed surgically. The cut surface of the mass was smooth, whitish and solid, and covered by the oral mucosal membrane. Histopathologically, the mass consisted mainly of reticular pattern of short spindle cells that stained positively for cytokeratin AE1/AE3, α-smooth muscle actin and p63, suggestive of a myoepithelial cell phenotype...
May 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28523098/incb24360-epacadostat-a-highly-potent-and-selective-indoleamine-2-3-dioxygenase-1-ido1-inhibitor-for-immuno-oncology
#3
Eddy W Yue, Richard Sparks, Padmaja Polam, Dilip Modi, Brent Douty, Brian Wayland, Brian Glass, Amy Takvorian, Joseph Glenn, Wenyu Zhu, Michael Bower, Xiangdong Liu, Lynn Leffet, Qian Wang, Kevin J Bowman, Michael J Hansbury, Min Wei, Yanlong Li, Richard Wynn, Timothy C Burn, Holly K Koblish, Jordan S Fridman, Tom Emm, Peggy A Scherle, Brian Metcalf, Andrew P Combs
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor 4f, INCB24360 (epacadostat). The molecular structure of INCB24360 contains several previously unknown or underutilized functional groups in drug substances, including a hydroxyamidine, furazan, bromide, and sulfamide. These moieties taken together in a single structure afford a compound that falls outside of "drug-like" space. Nevertheless, the in vitro ADME data is consistent with the good cell permeability and oral bioavailability observed in all species (rat, dog, monkey) tested...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28520773/development-of-the-highly-sensitive-dog-questionnaire-to-evaluate-the-personality-dimension-sensory-processing-sensitivity-in-dogs
#4
Maya Braem, Lucy Asher, Sibylle Furrer, Isabel Lechner, Hanno Würbel, Luca Melotti
In humans, the personality dimension 'sensory processing sensitivity (SPS)', also referred to as "high sensitivity", involves deeper processing of sensory information, which can be associated with physiological and behavioral overarousal. However, it has not been studied up to now whether this dimension also exists in other species. SPS can influence how people perceive the environment and how this affects them, thus a similar dimension in animals would be highly relevant with respect to animal welfare. We therefore explored whether SPS translates to dogs, one of the primary model species in personality research...
2017: PloS One
https://www.readbyqxmd.com/read/28520757/predicting-above-ground-density-and-distribution-of-small-mammal-prey-species-at-large-spatial-scales
#5
Lucretia E Olson, John R Squires, Robert J Oakleaf, Zachary P Wallace, Patricia L Kennedy
Grassland and shrub-steppe ecosystems are increasingly threatened by anthropogenic activities. Loss of native habitats may negatively impact important small mammal prey species. Little information, however, is available on the impact of habitat variability on density of small mammal prey species at broad spatial scales. We examined the relationship between small mammal density and remotely-sensed environmental covariates in shrub-steppe and grassland ecosystems in Wyoming, USA. We sampled four sciurid and leporid species groups using line transect methods, and used hierarchical distance-sampling to model density in response to variation in vegetation, climate, topographic, and anthropogenic variables, while accounting for variation in detection probability...
2017: PloS One
https://www.readbyqxmd.com/read/28520514/flea-and-small-mammal-species-composition-in-mixed-grass-prairies-implications-for-the-maintenance-of-yersinia-pestis
#6
Lauren P Maestas, Hugh B Britten
Maintenance of sylvatic plague in prairie dogs (Cynomis spp.) was once thought unlikely due to high mortality rates; yet more recent findings indicate that low-level enzootic plague may be maintained in susceptible prairie dog populations. Another hypothesis for the maintenance of sylvatic plague involves small mammals, other than prairie dogs, as an alternative reservoir in the sylvatic plague system. These hypotheses, however, are not mutually exclusive, as both prairie dogs and small mammals could together be driving sylvatic cycles of plague...
May 18, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28516494/recommendations-for-approaches-to-meticillin-resistant-staphylococcal-infections-of-small-animals-diagnosis-therapeutic-considerations-and-preventative-measures-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#7
REVIEW
Daniel O Morris, Anette Loeffler, Meghan F Davis, Luca Guardabassi, J Scott Weese
BACKGROUND: Multiple drug resistance (MDR) in staphylococci, including resistance to the semi-synthetic penicillinase-resistant penicillins such as meticillin, is a problem of global proportions that presents serious challenges to the successful treatment of staphylococcal infections of companion animals. OBJECTIVES: The objective of this document is to provide harmonized recommendations for the diagnosis, prevention and treatment of meticillin-resistant staphylococcal infections in dogs and cats...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28516493/diagnosis-and-treatment-of-dermatophytosis-in-dogs-and-cats-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#8
REVIEW
Karen A Moriello, Kimberly Coyner, Susan Paterson, Bernard Mignon
BACKGROUND: Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people. OBJECTIVES: The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28511287/generation-and-characterization-of-highly-purified-canine-schwann-cells-from-spinal-nerve-dorsal-roots-as-potential-new-candidates-for-transplantation-strategies
#9
Nicole Steffensen, Annika Lehmbecker, Ingo Gerhauser, Yimin Wang, Regina Carlson, Andrea Tipold, Wolfgang Baumgärtner, Veronika M Stein
Schwann cells (SCs) are promising candidates for transplantation-strategies in the central nervous system by promoting axonal regeneration. The dog represents a translational model for human spinal cord injury (SCI) for studies with new repair strategies after intervertebral disk herniation (IVDH). To overcome the necessity for an additional surgical procedure, for the first time a protocol for isolation, and purification of canine SCs from spinal-nerve-biopsies during standard hemilaminectomy in IVDH affected paraplegic dogs for potential transplantation was developed...
May 16, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28508917/dowel-pinning-for-metacarpal-and-metatarsal-fractures-in-dogs
#10
Matthias Kornmayer, Ulrike Matis
OBJECTIVE: To evaluate a dowel pinning technique for metacarpal and metatarsal fractures in dogs. MATERIAL AND METHODS: Medical records of 13 dogs with complete clinical and radiographic follow-up examinations after a median observation time of 5 months were evaluated retrospectively. Assessment included fracture data, number of stabilized bones versus number of fractured bones and parameters of internal fixation including postoperative axial alignment and position of implants assessed on serial radiographs...
May 16, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28506792/discovery-of-a-novel-canine-respiratory-coronavirus-support-genetic-recombination-among-betacoronavirus1
#11
Shuai Lu, Yanqun Wang, Yingzhu Chen, Bingjie Wu, Kun Qin, Jincun Zhao, Yongliang Lou, Wenjie Tan
Although canine respiratory coronavirus (CRCoV) is an important respiratory pathogen that is prevalent in many countries, only one complete genome sequence of CRCoV (South Korea strain K37) has been obtained to date. Genome-wide analyses and recombination have rarely been conducted, as small numbers of samples and limited genomic characterization have previously prevented further analyses. Herein, we report a unique CRCoV strain, denoted strain BJ232, derived from a CRCoV-positive dog with a mild respiratory infection...
May 13, 2017: Virus Research
https://www.readbyqxmd.com/read/28498655/discovery-of-an-orally-bioavailable-benzimidazole-diacylglycerol-acyltransferase-1-dgat1-inhibitor-that-suppresses-body-weight-gain-in-diet-induced-obese-dogs-and-postprandial-triglycerides-in-humans
#12
Katsumasa Nakajima, Ricardo Chatelain, Kevin B Clairmont, Renee Commerford, Gary M Coppola, Thomas Daniels, Cornelia J Forster, Thomas A Gilmore, Yongjin Gong, Monish Jain, Aaron D Kanter, Youngshin Kwak, Jingzhou Li, Charles Daniel Meyers, Alan D Neubert, Paul Szklennik, Vivienne Tedesco, James Thompson, David Truong, Qing Yang, Brian K Hubbard, Michael H Serrano-Wu
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic acid, improving DGAT1 potency and gut permeability. Since DGAT1 is expressed in the small intestine, both 1 and 9 can suppress postprandial triglycerides during acute oral lipid challenges in rats and dogs. Interestingly, only 9 was found to be effective in suppressing body weight gain relative to control in a diet induced obese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control...
May 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28494704/endoscopic-cytology-for-the-diagnosis-of-chronic-enteritis-and-intestinal-lymphoma-in-dogs
#13
S Maeda, M Tsuboi, K Sakai, K Ohno, K Fukushima, H Kanemoto, S Hiyoshi-Kanemoto, Y Goto-Koshino, J K Chambers, T Yonezawa, K Uchida, N Matsuki
Although cytology is a rapid diagnostic procedure in dogs, the cytologic criteria of endoscopic biopsies for chronic enteritis and intestinal lymphoma are not well defined. An immediate diagnosis using cytology would benefit patients by enabling prompt initiation of therapy. The objective of this study was to investigate the correlation between the results of endoscopic cytology and histopathology. In this study, 167 dogs with clinical signs of chronic gastrointestinal disease were included. On the basis of histopathology, the following diagnoses were determined: lymphocytic-plasmacytic enteritis in 93 dogs; eosinophilic enteritis in 5 dogs; small cell intestinal lymphoma in 45 dogs; and large cell intestinal lymphoma in 24 dogs...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28493036/life-cycle-of-amblyomma-oblongoguttatum-acari-ixodidae-under-laboratory-conditions
#14
Thiago F Martins, Hermes R Luz, João Luiz H Faccini, Marcelo B Labruna
This study evaluated for the first time the life cycle of Amblyomma oblongoguttatum in the laboratory. For this purpose, larvae and nymphs were exposed to Gallus gallus (chicks), Rattus norvegicus (wistar rat), Calomys callosus (vesper mouse), Oryctolagus cuniculus (domestic rabbit), Cavia porcellus (guinea pig), and Didelphis albiventris (white-eared opossum). Nymphs were exposed to G. gallus, C. callosus, C. porcellus, O. cuniculus, R. norvegicus, and Nectomys squamipes (water rat). Adult ticks were exposed to domestic dogs...
May 10, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28483442/molecular-detection-and-genomic-characterization-of-torque-teno-canis-virus-in-domestic-dogs-in-guangxi-province-china
#15
Wenchao Sun, Changzhan Xie, Cao Liang, Min Zheng, Guanyu Zhao, Ping Zhang, Jicheng Han, Jie Jing, Shubo Wen, Pengpeng Xiao, Zhuodong Cui, Jinyong Zhang, Jingqiang Ren, Hao Liu, Huijun Lu, Ningyi Jin
The Torque teno canis virus (TTCaV) is a small virus with circular single-stranded DNA that has been reported to cause infections in dogs. The present study aimed to identify the presence of TTCaV in blood samples obtained from domestic dogs, and examine its diversity and evolution of the genomes. Five strains of TTCaV were detected, and the overall prevalence was found to be 7% (28/400). Phylogenetic analysis showed that the five genomes were closely clustered with the previously known Cf-TTV10 and LDL strains and formed a Thetatorque virus...
May 5, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28480802/optimization-of-fecal-cytology-in-the-dog-comparison-of-three-sampling-methods
#16
Petros S Frezoulis, Elisavet Angelidou, Anastasia Diakou, Timoleon S Rallis, Mathios E Mylonakis
Dry-mount fecal cytology (FC) is a component of the diagnostic evaluation of gastrointestinal diseases. There is limited information on the possible effect of the sampling method on the cytologic findings of healthy dogs or dogs admitted with diarrhea. We aimed to: (1) establish sampling method-specific expected values of selected cytologic parameters (isolated or clustered epithelial cells, neutrophils, lymphocytes, macrophages, spore-forming rods) in clinically healthy dogs; (2) investigate if the detection of cytologic abnormalities differs among methods in dogs admitted with diarrhea; and (3) investigate if there is any association between FC abnormalities and the anatomic origin (small- or large-bowel diarrhea) or the chronicity of diarrhea...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28473237/pharmacokinetic-and-screening-studies-of-the-interaction-between-mononuclear-phagocyte-system-and-nanoparticle-formulations-and-colloid-forming-drugs
#17
Andrew T Lucas, Leah B Herity, Zack A Kornblum, Andrew J Madden, Alberto Gabizon, Alexander V Kabanov, Rose T Ajamie, David M Bender, Palaniappan Kulanthaivel, Manuel V Sanchez-Felix, Henry A Havel, William C Zamboni
Studies have shown that nanoparticles (NPs) are cleared through the mononuclear phagocyte system (MPS). Pharmacokinetic studies of Doxil, DaunoXome, micellar doxorubicin (SP1049C) and small molecule (SM) doxorubicin were performed in SCID mice, Sprague-Dawley rats, and beagle dogs. An ex vivo MPS profiling platform was used to evaluate the interaction between the same agents, as well as colloid-forming and non-colloid forming SM drugs. In all species, the systemic clearance was highest for SP1049C and lowest for Doxil...
May 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28472238/do-female-dogs-age-differently-than-male-dogs
#18
Jessica M Hoffman, Dan G O'Neill, Kate E Creevy, Steven N Austad
Humans, as well as their closest ancestors, the higher African primates, exhibit female-biased survival and multiple sex differences in causes of death. However, the effects of sex on aging and longevity in an excellent model of human health, the companion dog, have not been well explored. Using two large independent databases on companion dog longevity and causes of death, we performed the most extensive analysis of sex differences in dog aging to date. Unlike the findings in humans, we observed only a small effect of sex on canine longevity...
May 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28467747/splenomegaly-in-small-breed-dogs-45-cases-2005-2011
#19
Erin E Corbin, Ryan P Cavanaugh, Pamela Schwartz, Katherine I Zawadzki, Taryn Donovan
OBJECTIVE To assess causes of splenomegaly and postsurgical outcomes in small-breed (ie, < 16-kg [< 35.2-lb]) dogs that underwent splenectomy and evaluate associations among malignant disease, hemoperitoneum, and survival time in these patients. DESIGN Retrospective case series. ANIMALS 45 client-owned dogs. PROCEDURES Medical records of 2 veterinary facilities were reviewed to identify small-breed dogs that underwent splenectomy and had a histologic diagnosis recorded. Data analyzed included signalment, diagnosis, presence or absence of hemoperitoneum, and survival time...
May 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28467600/recent-advancements-and-new-perspectives-in-animal-models-for-neurocysticercosis-immunopathogenesis
#20
REVIEW
N Arora, S Tripathi, P Kumar, P Mondal, A Mishra, A Prasad
Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human), and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies...
May 3, 2017: Parasite Immunology
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