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https://www.readbyqxmd.com/read/29331701/the-use-of-triiodothyronine-t3-in-the-treatment-of-bipolar-depression-a-review-of-the-literature
#1
REVIEW
T Parmentier, P Sienaert
BACKGROUND: There is a paucity of treatment options for bipolar depression. The use of triiodothyronine (T3) has been suggested as adjunctive treatment. METHODS: A search on Medline, Limo and ScienceDirect was performed using the search terms bipolar disorder, bipolar depression, treatment resistant, treatment refractory, thyroid hormones, triiodothyronine, T3, acceleration and augmentation. RESULTS: We retrieved three open studies, one comparative study, two double blind and one retrospective chart review...
January 9, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29330662/yogurt-consumption-is-associated-with-higher-nutrient-intake-diet-quality-and-favourable-metabolic-profile-in-children-a-cross-sectional-analysis-using-data-from-years-1-4-of-the-national-diet-and-nutrition-survey-uk
#2
D A Hobbs, D I Givens, J A Lovegrove
PURPOSE: Yogurt consumption has been associated with higher nutrient intakes, better diet quality and improved metabolic profiles in adults. Few studies have investigated these associations in children. This study investigated the association of yogurt consumption with nutrient intakes, diet quality and metabolic profile in British children. METHODS: Data from  1687 children aged 4-10 and 11-18 years of the National Diet and Nutrition Survey (NDNS) years 1-4 were analysed...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29329567/modified-pilates-as-an-adjunct-to-standard-physiotherapy-care-for-urinary-incontinence-a-mixed-methods-pilot-for-a-randomised-controlled-trial
#3
Adi Lausen, Louise Marsland, Samantha Head, Joanna Jackson, Berthold Lausen
BACKGROUND: Urinary incontinence (UI) is a distressing condition affecting at least 5 million women in England and Wales. Traditionally, physiotherapy for UI comprises pelvic floor muscle training, but although evidence suggests this can be effective it is also recognised that benefits are often compromised by patient motivation and commitment. In addition, there is increasing recognition that physical symptoms alone are poor indicators of the impact of incontinence on individuals' lives...
January 12, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29329310/medication-discrepancies-across-multiple-care-transitions-a-retrospective-longitudinal-cohort-study-in-italy
#4
Marco Bonaudo, Maria Martorana, Valerio Dimonte, Alessandra D'Alfonso, Giulio Fornero, Gianfranco Politano, Maria Michela Gianino
PURPOSE: Medication discrepancies are defined as unexplained differences among regimens across different sites of care. The problem of medication discrepancies that occur during the entire care pathway from hospital admission to a local care setting discharge (namely all types of settings dedicated to formal care other than hospitals) has received little attention in the medical literature. The present study aims to (1) determine the prevalence of medication discrepancies that occur during the entire care pathway from hospital admission to local care setting discharge, (2) describe the discrepancy and medication type, and (3) identify potential risk factors for experiencing medication discrepancies in patient care transitions...
2018: PloS One
https://www.readbyqxmd.com/read/29329049/the-traumatized-body-long-term-ptsd-and-its-implications-for-the-orientation-towards-bodily-signals
#5
Noga Tsur, Ruth Defrin, Yael Lahav, Zahava Solomon
Orientation to bodily signals is defined as the way somatic sensations are attended, perceived and interpreted. Research suggests that trauma exposure, particularly the pathological reaction to trauma (i.e., PTSD), is associated with catastrophic and frightful orientation to bodily signals. However, little is known regarding the long-term ramifications of trauma exposure and PTSD for orientation to bodily signals. Less is known regarding which PTSD symptom cluster manifests in the 'somatic route' through which orientation to bodily signals is altered...
January 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29327600/population-based-serum-omentin-1-levels-paradoxical-association-with-cardiometabolic-disorders-primarily-in-men
#6
Altan Onat, Evin Ademoglu, Yusuf Karadeniz, Gunay Can, Ahmet Okan Uzun, Barıs Simsek, Aysem Kaya
AIM: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methodology: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men...
January 12, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29325459/is-cord-blood-hepcidin-influenced-by-the-low-grade-acute-phase-response-occurring-during-delivery-%C3%A2-a-small-scale-longitudinal-study
#7
Michael Hoppe, Lena Hulthén, Gösta Samuelson
AIM: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6 and biomarkers of fetal iron status. MATERIALS AND METHODS: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth. RESULTS: In T3, S-ferritin (median 14 µg/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29325045/mean-high-dose-l-thyroxine-treatment-is-efficient-and-safe-to-achieve-a-normal-iq-in-young-adult-patients-with-congenital-hypothyroidism
#8
Paulina Aleksander, Michaela Brückner-Spieler, Anne-Marie Stöhr, Erwin Lankes, Peter Kühnen, Dirk Schnabel, Andrea Ernert, Walter Stäblein, Maria E Craig, Oliver Blankenstein, Annette Grüters, Heiko Krude
Context: The optimal levothyroxine (LT4) dose required to treat congenital hypothyroidism (CH) remains unclear, with a debate if higher starting doses (>10µg/kg) are necessary and safe for normal Intelligence Quotient (IQ). Objective: To examine the psychomotor, metabolic and quality of life outcome in patients with CH treated with a mean high initial LT4 dose. Design, settings, participants: A cross- sectional cohort study of CH patients identified in the Berlin newborn screening programme from 1979-2003...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29324825/early-and-later-phases-satellite-cell-responses-and-myonuclear-content-with-resistance-training-in-young-men
#9
Felipe Damas, Cleiton A Libardi, Carlos Ugrinowitsch, Felipe C Vechin, Manoel E Lixandrão, Tim Snijders, Joshua P Nederveen, Aline V Bacurau, Patricia Brum, Valmor Tricoli, Hamilton Roschel, Gianni Parise, Stuart M Phillips
Satellite cells (SC) are associated with skeletal muscle remodelling after muscle damage and/or extensive hypertrophy resulting from resistance training (RT). We recently reported that early increases in muscle protein synthesis (MPS) during RT appear to be directed toward muscle damage repair, but MPS contributes to hypertrophy with progressive muscle damage attenuation. However, modulations in acute-chronic SC content with RT during the initial (1st-wk: high damage), early (3rd-wk: attenuated damage), and later (10th-wk: no damage) stages is not well characterized...
2018: PloS One
https://www.readbyqxmd.com/read/29323886/bisphenol-f-disrupts-thyroid-hormone-signaling-and-postembryonic-development-in-xenopus-laevis
#10
Min Zhu, Xiaoying Chen, Yuanyuan Li, Nuoya Yin, Francesco Faiola, Zhanfen Qin, Wuji Wei
The safety of bisphenol A (BPA) alternatives has attracted much attention due to their wide use. In this study, we investigated the effects of bisphenol F (BPF), an alternative to BPA, on thyroid hormone (TH) signaling and postembryonic development in vertebrates using T3-induced and spontaneous Xenopus metamorphosis as models. We found that in the T3-induced metamorphosis assay, higher concentrations of BPF (100-10000 nM) antagonized T3-induced TH-response gene transcription and morphological changes including intestinal remodeling in a concentration-dependent manner, whereas 10 nM BPF exerted stimulatory effects on T3-induced integral metamorphosis when inhibited T3-induced TH-response gene transcription, demonstrating TH signaling disrupting effects of BPF...
January 11, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29323513/the-five-factor-borderline-inventory-behavioral-outcomes-across-time
#11
Ashley C Helle, Hilary L DeShong, Amanda N Baraldi, Stephanie N Mullins-Sweatt
The Five-Factor Borderline Inventory Short Form (FFBI-SF) is a 48-item dimensional measure of borderline personality disorder (BPD) that was developed from the Five-factor model (FFM). Previous research has examined the relationships of the FFBI-SF to the FFM and BPD. The purpose of the current study was to investigate the relationship of FFBI-SF scales with behavioral outcomes, such as self-injury, physical fights, panic symptoms, promiscuous sex, theft, attempted suicide, reckless driving, and binge eating...
January 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29323457/impact-of-subchronic-exposure-to-triclosan-and-or-fluoride-on-estrogenic-activity-in-immature-female-rats-the-expression-pattern-of-calbindin-d9k-and-estrogen-receptor-%C3%AE-genes
#12
Yasmina M Abd-Elhakim, Amany T Mohammed, Haytham A Ali
This study explored the influence of triclosan (TCS) in the absence and presence of sodium fluoride (NaF) on estrogenic activity and thyroid function of adolescent female rats. The results indicated that the individual exposure to TCS evoked a significant decline in T3 and T4 but the levels of estradiol, FSH, and LH were significantly elevated beside marked up regulation of calbindin-D9k and estrogen α mRNA expression. On the other hand, the single exposure to NaF causes insignificant changes in thyroid hormones, but evoked a trend toward an increase in both estradiol and LH levels...
January 11, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29323298/a-metabolic-function-of-fgfr3-tacc3-gene-fusions-in-cancer
#13
Véronique Frattini, Stefano M Pagnotta, Tala, Jerry J Fan, Marco V Russo, Sang Bae Lee, Luciano Garofano, Jing Zhang, Peiguo Shi, Genevieve Lewis, Heloise Sanson, Vanessa Frederick, Angelica M Castano, Luigi Cerulo, Delphine C M Rolland, Raghvendra Mall, Karima Mokhtari, Kojo S J Elenitoba-Johnson, Marc Sanson, Xi Huang, Michele Ceccarelli, Anna Lasorella, Antonio Iavarone
Chromosomal translocations that generate in-frame oncogenic gene fusions are notable examples of the success of targeted cancer therapies. We have previously described gene fusions of FGFR3-TACC3 (F3-T3) in 3% of human glioblastoma cases. Subsequent studies have reported similar frequencies of F3-T3 in many other cancers, indicating that F3-T3 is a commonly occuring fusion across all tumour types. F3-T3 fusions are potent oncogenes that confer sensitivity to FGFR inhibitors, but the downstream oncogenic signalling pathways remain unknown...
January 11, 2018: Nature
https://www.readbyqxmd.com/read/29322981/expansile-manubriotomy-for-ventral-cervicothoracic-junction-disease
#14
Sudhir Dubey, Amit Agrawal
Cervicothoracic junction can be approached anteriorly, anterolaterally, posterolaterally, and posteriorly. The anterior approaches in this region best address the ventral vertebral body disease but may cause significant morbidity. Twelve patients with their disease process located ventral to the spinal cord in the cervicothoracic junction underwent expansile manubriotomy and corpectomy. Eleven patients underwent fusion. One patient underwent an oblique corpectomy. All patients had their disease process from T1 to T3 vertebral levels...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322512/serum-inflammatory-markers-in-relation-to-prostate-cancer-severity-and-death-in-the-swedish-amoris-study
#15
R Arthur, R Williams, H Garmo, L Holmberg, P Stattin, H Malmstrom, M Lambe, N Hammar, G Walldius, D Robinsson, I Jungner, M Van Hemelrijck
Inflammation is a well-documented driver of cancer development and progression. However, little is known about its role in prostate carcinogenesis. Thus, we examined the association of C-reactive protein (CRP), haptoglobin, albumin and white blood cells (WBC) with prostate cancer (PCa) severity (defined by PCa risk category and clinicopathological characteristics) and progression (defined by PCa death). We selected 8471 Swedish men with newly diagnosed PCa who had exposure measurements taken approximately 14 years prior to diagnosis...
January 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29322401/is-it-possible-to-cure-the-symptoms-of-the-overactive-bladder-in-women
#16
Jan Krhut, Alois Martan, Roman Zachoval, Tomas Hanus, Lukas Horcicka, Kamil Svabík, Peter Zvara
PURPOSE: To evaluate the feasibility of discontinuing treatment with mirabegron once symptoms have subsided in patients with overactive bladder (OAB). METHODS: The present study evaluated a total of 159 female OAB patients (age 62.9 ± 12.36), each of which were prescribed 50 mg/day mirabegron (Time point 1-T1). Data obtained from voiding diaries and patient-reported outcome variables were assessed during follow-up visits at months 1, 3, 6, 12, 18 (T2), and 21 (T4)...
January 10, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#17
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
January 10, 2018: Endocrine
https://www.readbyqxmd.com/read/29322223/is-the-timed-loaded-standing-test-a-valid-measure-of-back-muscle-endurance-in-people-with-vertebral-osteoporosis
#18
M Newman, R Newman, T Hughes, K Vadher, K L Barker
Timed loaded standing (TLS) is a suggested measure of back muscle endurance for people with vertebral osteoporosis. Surface electromyography revealed back muscles work harder and fatigue during TLS. The test end-point and total time were associated with back fatigue. The findings help demonstrate the concurrent validity of the TLS test. INTRODUCTION: The TLS test is suggested as a measure of back muscle endurance for patients with vertebral osteoporosis. However, to date, no study has demonstrated that TLS does measure back extensor or erector spinae (ES) muscle endurance...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29321194/polygenic-hazard-score-to-guide-screening-for-aggressive-prostate-cancer-development-and-validation-in-large-scale-cohorts
#19
Tyler M Seibert, Chun Chieh Fan, Yunpeng Wang, Verena Zuber, Roshan Karunamuni, J Kellogg Parsons, Rosalind A Eeles, Douglas F Easton, ZSofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, Kenneth Muir, Henrik Grönberg, Fredrik Wiklund, Markus Aly, Johanna Schleutker, Csilla Sipeky, Teuvo Lj Tammela, Børge G Nordestgaard, Sune F Nielsen, Maren Weischer, Rasmus Bisbjerg, M Andreas Røder, Peter Iversen, Tim J Key, Ruth C Travis, David E Neal, Jenny L Donovan, Freddie C Hamdy, Paul Pharoah, Nora Pashayan, Kay-Tee Khaw, Christiane Maier, Walther Vogel, Manuel Luedeke, Kathleen Herkommer, Adam S Kibel, Cezary Cybulski, Dominika Wokolorczyk, Wojciech Kluzniak, Lisa Cannon-Albright, Hermann Brenner, Katarina Cuk, Kai-Uwe Saum, Jong Y Park, Thomas A Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Judith A Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, David S Karow, Ian G Mills, Ole A Andreassen, Anders M Dale
OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to select single nucleotide polymorphisms (SNPs) associated with diagnosis. These polymorphisms were incorporated into a survival analysis to estimate their effects on age at diagnosis of aggressive PCa (that is, not eligible for surveillance according to National Comprehensive Cancer Network guidelines; any of Gleason score ≥7, stage T3-T4, PSA (prostate specific antigen) concentration ≥10 ng/L, nodal metastasis, distant metastasis)...
January 10, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29320567/myocardium-of-patients-with-dilated-cardiomyopathy-presents-altered-expression-of-genes-involved-in-thyroid-hormone-biosynthesis
#20
Carolina Gil-Cayuela, Ana Ortega, Estefanía Tarazón, Luis Martínez-Dolz, Juan Cinca, José Ramón González-Juanatey, Francisca Lago, Esther Roselló-Lletí, Miguel Rivera, Manuel Portolés
BACKGROUND: The association between dilated cardiomyopathy (DCM) and low thyroid hormone (TH) levels has been previously described. In these patients abnormal thyroid function is significantly related to impaired left ventricular (LV) function and increased risk of death. Although TH was originally thought to be produced exclusively by the thyroid gland, we recently reported TH biosynthesis in the human ischemic heart. OBJECTIVES: Based on these findings, we evaluated whether the genes required for TH production are also altered in patients with DCM...
2018: PloS One
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