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https://www.readbyqxmd.com/read/29782957/the-role-of-monoamines-in-the-development-of-alzheimer-s-disease-and-neuroprotective-effect-of-a-proline-rich-polypeptide
#1
Konstantin Yenkoyan, Katarine Fereshetyan, Senik Matinyan, Vergine Chavushyan, Michail Aghajanov
INTRODUCTION: We have analyzed the alterations in the brain monoaminergic system using the rat model of AD-like pathology. In addition, we have investigated potential neuroprotective effects of the hypothalamic proline-rich polypeptide (PRP-1). METHODS: Histochemical staining, HPLC, chemiluminescent and bioluminescence assays. RESULTS: The levels of monoamines in the target AD brain structures were found elevated, except serotonin, which was unaffected in both hippocampus and brainstem and decreased in frontal cortex...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29781178/the-effects-of-platelet-rich-plasma-on-hypertrophic-scars-fibroblasts
#2
Seung Min Nam, Yong Bae Kim
We hypothesised that a feedback mechanism of the transforming growth factor (TGF)-β1 signalling pathway, triggered by high-level TGF-β1, activates platelet-rich plasma (PRP) release to reduce connective tissue growth factor (CTGF) production and expression of CTGF mRNA in hypertrophic scar dermal fibroblasts. Primary dermal fibroblasts were isolated from cultures of hypertrophic scars. Cells were cultured after addition of serum-free Dulbecco's modified Eagle's medium supplemented with 5% (wt/vol) PRP or platelet-poor plasma (PPP)...
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29775888/therapeutic-impact-of-rhuepo-on-abnormal-platelet-app-bace-1-presenilin-1-adam-10-and-a%C3%AE-expressions-in-chronic-kidney-disease-patients-with-cognitive-dysfunction-like-alzheimer-s-disease-a-pilot-study
#3
Vinothkumar G, Krishnakumar S, Sureshkumar, Shivashekar G, Sreedhar S, Preethikrishnan, Dinesh S, Sundaram A, Balakrishnan D, Riya, Venkataraman P
BACKGROUND: Cognitive dysfunction is reported to be a major cause of morbidity in chronic kidney disease (CKD). The senile plaques (SPs) in the brain are one of the most pathophysiological characteristics of cognitive dysfunction and its major constituent amyloid β (Aβ) released from amyloid precursor protein (APP) by β (BACE1) and γ (presenilin 1) secretases . Platelets contain more than 95% of the circulating APP and implicate as a candidate biomarker for cognitive decline. Recombinant human erythropoietin (rHuEPO) is a standard therapy for anemia in CKD and also acts as a neuroprotective agent...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29772339/wound-healing-effects-of-a-curcuma-zedoaria-polysaccharide-with-platelet-rich-plasma-exosomes-assembled-on-chitosan-silk-hydrogel-sponge-in-a-diabetic-rat-model
#4
Ning Xu, Lili Wang, Junjie Guan, Chao Tang, Ning He, Wei Zhang, Shiping Fu
One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29772187/platelet-rich-plasma-releasate-promotes-regeneration-and-decreases-inflammation-and-apoptosis-of-injured-skeletal-muscle
#5
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S Pang
BACKGROUND: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors' previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. PURPOSE: To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770602/full-title-cultures-of-a-human-synovial-cell-line-to-evaluate-platelet-rich-plasma-and-hyaluronic-acid-effects
#6
E Olivotto, G Merli, E Assirelli, C Cavallo, E Belluzzi, R Ramonda, M Favero, G Filardo, A Roffi, E Kon, B Grigolo
Synovial inflammation plays an important role in osteoarthritis (OA) pathogenesis. Different biological compounds have been tested mainly on chondrocytes, to treat early stages of OA. However, since OA has been recently defined as "an organ" pathology, investigation on synoviocytes is also needed. Therefore the aim of the present study was to validate a human fibroblast-like synoviocytes cell line (K4IM) to test the effects of platelet-rich plasma (PRP) and hyaluronan (HA) on anabolic and catabolic gene expression and on HA secretion from cell cultures...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29768536/comparison-of-platelet-rich-plasma-versus-fibrin-glue-on-colonic-anastomoses-in-rats
#7
Yusuf Kenan Daglioglu, Ozgul Duzgun, Inanc Samil Sarici, Kemal Turker Ulutas
PURPOSE: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. METHODS: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29766749/enhanced-sternal-healing-via-platelet-rich-plasma-and-biodegradable-gelatin-hydrogel
#8
Masafumi Shibata, Gen Takagi, Mitsuhiro Kudo, Jiro Kurita, Yoko Kawamoto, Yasuo Miyagi, Mikimoto Kanazashi, Takashi Sakatani, Zenya Naito, Yasuhiko Tabata, Masaaki Miyamoto, Takashi Nitta
Platelet-rich plasma (PRP) contains numerous growth factors and promotes bone fracture healing. The aim of this study was to evaluate the effectiveness of the controlled release of PRP from biodegradable gelatin hydrogel for promoting healing in a rabbit ischemic sternal model. PRP was prepared from the whole blood of a Japanese white rabbit. Sixteen rabbits were randomized into four groups (each n = 4) and all underwent median sternotomy and bilateral internal thoracic artery removal. Before the sternum was closed, the following solutions were applied between the sternum incisions in three of the groups: 30 mg of gelatin hydrogel incorporating 300 μL of phosphate-buffered saline, 300 μL of a solution form of PRP, or 30 mg of gelatin hydrogel incorporating 300 μL of PRP (PRP+Gel)...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29760725/the-effects-of-hyperacute-serum-on-the-elements-of-the-human-subchondral-bone-marrow-niche
#9
Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza
Mesenchymal stem cells (MSCs) are widely used in laboratory experiments as well as in human cell therapy. Their culture requires animal sera like fetal calf serum (FCS) as essential supplementation; however, animal sera pose a risk for clinical applications. Human blood derivatives, for example, platelet-rich plasma (PRP) releasates, are potential replacements of FCS; however, it is unclear which serum variant has the best effect on the given cell or tissue type. Additionally, blood derivatives are commonly used in musculoskeletal diseases like osteoarthritis (OA) or osteonecrosis as "proliferative agents" for the topical MSC pool...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29755531/adjunctive-platelet-rich-plasma-prp-in-infrabony-regenerative-treatment-a-systematic-review-and-rct-s-meta-analysis
#10
REVIEW
Mubashir Saleem, Flavio Pisani, Faisal Maqbool Zahid, Ioannis Georgakopoulos, Teuta Pustina-Krasniqi, Edit Xhajanka, Maher Almasri
Background and Objective: The purpose of this study was to highlight the clinical performance of platelet-rich plasma (PRP) used as an adjunctive tool for regeneration in infrabony periodontal defects using different biomaterials or performing different surgical flap approaches. Comparative evaluation of main clinical outcomes as probing pocket depth reduction, clinical attachment gain, and recession reduction with and without the use of PRP has been analysed. Materials and Methods: According to the focused question, an electronic and hand searching has been performed up to December 2016...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29754526/recurrent-pityriasis-rubra-pilaris-a-case-report
#11
Megan E MacGillivray, Loretta Fiorillo
Pityriasis rubra pilaris (PRP) is an uncommon papulosquamous dermatosis characterized by follicular, erythematous, hyperkeratotic papules coalescing to salmon-coloured plaques with islands of sparing. The disease tends to be self-limited and resolves spontaneously after a few years. In some cases, the disease is persistent. However, recurrence of this disease has rarely been described. An 8-year-old male was diagnosed with type III (classic juvenile) PRP. He was treated with acitretin, and his skin was clear after 6 months...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29745047/systematic-review-of-the-efficacy-of-fat-grafting-and-platelet-rich-plasma-for-wound-healing
#12
Oliver J Smith, Muholan Kanapathy, Ankur Khajuria, Max Prokopenko, Nadine Hachach-Haram, Haroon Mann, Ash Mosahebi
Adipose-derived stem cells found in fat grafts may have significant healing properties. When fat is combined with autologous platelet-rich plasma (PRP), there may be enhanced healing effects due to the pro-angiogenic and anti-inflammatory effects of PRP. This study aimed to evaluate the current evidence on fat grafting in combination with PRP for wound healing to establish the efficacy of this technique. A comprehensive search in the MEDLINE, EMBASE, CENTRAL, Science Citation Index, and Google Scholar databases (to March 2017) was conducted to identify studies on fat grafting and PRP for wound healing...
May 9, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29744432/bone-grafts-and-biomaterials-substitutes-for-bone-defect-repair-a-review
#13
REVIEW
Wenhao Wang, Kelvin W K Yeung
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29741923/effect-of-intraoperative-platelet-rich-plasma-treatment-on-postoperative-donor-site-knee-pain-in-patellar-tendon-autograft-anterior-cruciate-ligament-reconstruction-a-double-blind-randomized-controlled-trial
#14
Brian L Walters, David A Porter, Sarah J Hobart, Benjamin B Bedford, Daniel E Hogan, Malachy M McHugh, Devon A Klein, Kendall Harousseau, Stephen J Nicholas
BACKGROUND: Donor site morbidity in the form of anterior knee pain is a frequent complication after bone-patellar tendon-bone (BPTB) autograft anterior cruciate ligament (ACL) reconstruction. Hypothesis/Purpose: The purpose was to examine the effect of the intraoperative administration of platelet-rich plasma (PRP) on postoperative kneeling pain. It was hypothesized that PRP treatment would reduce knee pain. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29740270/therapeutic-effect-of-platelet-rich-plasma-in-rat-spinal-cord-injuries
#15
Nan-Fu Chen, Chun-Sung Sung, Zhi-Hong Wen, Chun-Hong Chen, Chien-Wei Feng, Han-Chun Hung, San-Nan Yang, Kuan-Hao Tsui, Wu-Fu Chen
Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are an abundant source of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), and epithelial growth factor (EGF). The complex mechanisms underlying spinal cord injury (SCI) diminish intrinsic repair and neuronal regeneration...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29737237/blood-plasma-derivatives-for-tissue-engineering-and-regenerative-medicine-therapies
#16
Sara Santos, Olafur E Sigurjonsson, Catarina Custodio, João Filipe Colardelle da Luz Mano
Platelet-rich plasma (PRP) and its derivatives have been investigated and applied in regenerative medicine. The use of PRP as a supplement of cell culture media has consistently shown to potentiate stem cell proliferation, migration, and differentiation. In addition, the clinical utility of PRP is supported by evidence that PRP contains high concentrations of growth factors and proteins which contribute to the regenerative process. PRP based therapies are cost effective and also benefit from the accessibility and safety of using the patient's own growth factors...
May 8, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29736577/prp-therapy
#17
Ibrahim Fatih Cengiz, J Miguel Oliveira, Rui L Reis
Osteochondral lesions remain as a clinical challenge despite the advances in orthopedic regenerative strategies. Biologics, in particular, platelet-rich plasma, has been applied for the reparative and regenerative effect in many tissues, and osteochondral tissue is not an exception. Platelet-rich plasma is an autologous concentrate prepared from the collected blood; thus, this safe application is free of immune response or risk of transmission of disease. It has a high potential to promote regeneration, thanks to its content, and can be applied alone or can reinforce a tissue engineering strategy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29735884/polysaccharides-extracted-from-rhizoma-pleionis-have-antitumor-properties-in-vitro-and-in-an-h22-mouse-hepatoma-ascites-model-in-vivo
#18
Yukun Fang, Anhong Ning, Sha Li, Shaozheng Zhou, Lei Liu, Thomson Patrick Joseph, Mintao Zhong, Jilong Jiao, Wei Zhang, Yonghui Shi, Meishan Zhang, Min Huang
Malignant ascites is a highly severe and intractable complication of advanced or recurrent malignant tumors that is often immunotherapy-resistant. Rhizoma Pleionis is widely used in traditional medicine as an antimicrobial and anticancer agent, but its effectiveness in treating malignant ascites is unclear. In the current study, we investigated the effect of polysaccharides isolated from Rhizoma Pleionis (PRP) on murine hepatocarcinoma H22 cells in an ascites model. We have found that the main components of PRP, that presented a relative molecular weight of 383...
May 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29732431/platelet-rich-plasma-injections-an-emerging-therapy-for-chronic-discogenic-low-back-pain
#19
REVIEW
Suja Mohammed, James Yu
Autologous platelet-rich plasma (PRP) injections have been investigated in recent years as an emerging therapy for various musculoskeletal conditions, including lumbar degenerative disc disease. Although PRP has received increasing attention from medical science experts, comprehensive clinical reports of its efficacy are limited to those treating knee osteoarthritis and epicondylitis. Use of PRP is gaining popularity in the area of degenerative disc disease, but there is a clear need for reliable clinical evidence of its applications and effectiveness...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29729760/editorial-commentary-platelet-rich-plasma-fountain-of-youth-cart-before-the-horse-or-both
#20
EDITORIAL
Matthew J Salzler
Platelet-rich plasma (PRP) injections have gained widespread popularity for the treatment of many orthopaedic conditions including osteoarthritis of the knee. Despite its increasing usage, there is comparatively little evidence regarding the mechanisms of action and relative roles of the multiple growth factors contained within PRP. That said, although future research will clarify the issue, current evidence suggests that PRP is safe and, for the treatment of knee osteoarthritis, effective.
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
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