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https://www.readbyqxmd.com/read/28086781/effects-of-the-intradiscal-implantation-of-stromal-vascular-fraction-plus-platelet-rich-plasma-in-patients-with-degenerative-disc-disease
#1
Comella Kristin, Silbert Robert, Parlo Michelle
BACKGROUND: Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. The SVF contains a mixture of cells including ADSCs and growth factors and has been depleted of the adipocyte (fat cell) population. We evaluated the safety and efficacy of administering SVF and PRP intra-discally into patients with degenerative disc disease. METHODS: A total of 15 patients underwent a local tumescent liposuction procedure to remove approximately 60 ml of fat tissue...
January 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28080113/higher-order-cognitive-control-in-dual-tasks-evidence-from-task-pair-switching
#2
Patricia Hirsch, Sophie Nolden, Iring Koch
In the present study, we combined the psychological refractory period (PRP) paradigm with a novel task-pair switching logic which enabled us to isolate performance costs occurring at the global level of task-pairs. In Experiment 1, in which we used conceptually overlapping responses for Task 1 (T1) and Task 2 (T2), we generated 3 task-pairs by combining 1 of 3 visual tasks (T1) with an auditory task (T2). In addition to worse performance after a short SOA than a long SOA (i.e., PRP effect), we found impaired performance in n - 1 task-pair switches as compared to n - 1 task-pair repetitions (i...
January 12, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28076885/cross-linking-of-porcine-acellular-dermal-matrices-negatively-affects-induced-neovessel-formation-using-platelet-rich-plasma-in-a-rat-model-of-hernia-repair
#3
Joseph S Fernandez-Moure, Jeffrey L Van Eps, Leif Peterson, Beverly A Shirkey, Zachary K Menn, Fernando Cabrera, Azim Karim, Ennio Tasciotti, Bradley K Weiner, Warren A Ellsworth
The degree of crosslinking within acellular dermal matrices (ADM) seems to correlate to neovascularization when used in ventral hernia repair (VHR). Platelet-rich plasma (PRP) enhances wound healing through several mechanisms including neovascularization, but research regarding its effect on soft tissue healing in VHR is lacking. We sought to study the effect of crosslinking on PRP-induced neovascularization in a rodent model of bridging VHR. We hypothesized that ADM crosslinking would negatively affect PRP-induced neovessel formation...
January 11, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28072756/rapid-testing-for-creutzfeldt-jakob-disease-in-donors-of-cornea
#4
Luisa Gregori, Arthur Serer, Kristy L McDowell, Juraj Cervenak, David M Asher
BACKGROUND: Creutzfeldt-Jakob disease (CJD) has been accidentally transmitted by contaminated corneal transplants. Eye donors are not ordinarily tested for CJD, in part because an easy test is not available. We propose a relatively simple postmortem procedure to collect brain samples without performing full autopsy and show that a test currently marketed for veterinary diagnosis would offer an effective screening test. METHODS: We selected 6 brains from confirmed cases of human sporadic CJD and sampled each in triplicate (18 specimens), 28 control brains of individuals with non-CJD neurodegenerative diseases and 10 normal brains...
January 9, 2017: Transplantation
https://www.readbyqxmd.com/read/28066748/the-use-of-platelet-rich-plasma-to-augment-conservative-and-surgical-treatment-of-hip-and-pelvic-disorders
#5
REVIEW
Matthew J Kraeutler, Tigran Garabekyan, Omer Mei-Dan
BACKGROUND: In recent years, platelet-rich plasma (PRP) has gained popularity within the orthopaedic community as a treatment modality to enhance tissue healing. PURPOSE: This review aims to concisely present the current indications for PRP injections in the treatment of hip and pelvic pathologies and to describe some novel applications for PRP which have not yet been reported in the literature. METHODS: We reviewed the literature on the non-operative and operative indications for PRP in the treatment of hip and pelvic pathologies...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066732/conservative-management-of-tendinopathies-around-hip
#6
REVIEW
Antonio Frizziero, Filippo Vittadini, Andrea Pignataro, Giuseppe Gasparre, Carlo Biz, Pietro Ruggieri, Stefano Masiero
BACKGROUND: The anatomy of hip is widely complex and several anatomical structures interact and contribute to its functioning. For position and role, hip and the surrounding tendons, which have their insertion around, are overstressed and often overloaded, especially in athletes. This could lead to the developing of several tendinopathies, among which the differential diagnosis is often complicated. Many conservative treatments are used in clinical practice, while actually, no defined conservative protocol is recommended...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28063003/effect-of-poly-l-arginine-in-inhibiting-scrapie-prion-protein-of-cultured-cells
#7
Muhammad Waqas, Hye-Mi Lee, Jeeyoung Kim, Glenn Telling, Jin-Ki Kim, Dae-Hwan Kim, Chongsuk Ryou
Biological effect of poly-L-arginine (PLR), the linear homopolymer comprised of L-arginine, was investigated to determine the activity of suppressing prions. PLR decreased the level of scrapie prion protein (PrP(Sc)) in cultured cells permanently infected with prions in a concentration-dependent manner. The PrP(Sc) inhibition efficacy of PLR was greater than that of another prion-suppressant poly-L-lysine (PLK) in a molecular mass-dependent fashion. The effective concentration of PLR to inhibit prions was achieved safely below the cytotoxic concentrations, and overall cytotoxicity of PLR was similar to that of PLK...
January 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28061343/maternal-urinary-paraben-levels-and-offspring-size-at-birth-from-a-chinese-birth-cohort
#8
Chuansha Wu, Wenqian Huo, Yuanyuan Li, Bin Zhang, Yanjian Wan, Tongzhang Zheng, Aifen Zhou, Zhong Chen, Minzheng Qian, Yingshuang Zhu, Yangqian Jiang, Hongxiu Liu, Jie Hu, Xi Chen, Bing Xu, Wei Xia, Shunqing Xu
BACKGROUND: Parabens are suspected to impair fetal growth because of their endocrine disrupting effects. Epidemiological studies regarding the effects of prenatal exposure to parabens on birth outcomes are limited. OBJECTIVES: Our aim was to evaluate the association between prenatal paraben exposure and size of infants at birth. METHODS: Within the longitudinal Healthy Baby Cohort (HBC) in Hubei Province, China, we randomly selected 1006 mother-infant pairs recruited in Wuhan City in 2014...
December 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/28061032/effects-of-platelet-rich-plasma-with-concomitant-use-of-a-corticosteroid-on-tenocytes-from-degenerative-rotator-cuff-tears-in-interleukin-1%C3%AE-induced-tendinopathic-conditions
#9
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sue Shin
BACKGROUND: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28046424/su-g-tep2-03-comparison-of-standard-dosimetry-protocol-in-japan-and-aapm-tg-51-addendum-in-order-to-establish-optimal-dosimetry-for-fff-beam
#10
T Matsunaga, N Hayashi, Y Adachi, M Nozue
PURPOSE: Japan Standard Dosimetry of Absorbed dose to water in external beam radiotherapy (JSDP12) is widely used to measure radiation dose in radiotherapy. However, JSDP12 does not take flattening-filter-free (FFF) beam into consideration. In addition, JSDP12 applied TPR20,10 for dose quality index for photon beam. The purpose of this study is to compare JSDP12 with AAPM TG-51 addendum in order to establish optimal dosimetry procedure for FFF beam. METHOD: We evaluated the ion-recombination factor (ks) and the correction factor of radial beam profile (Prp) in FFF beam dosimetry...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042318/exosomes-derived-from-platelet-rich-plasma-promote-the-re-epithelization-of-chronic-cutaneous-wounds-via-activation-of-yap-in-a-diabetic-rat-model
#11
Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Ting Yuan, Chang-Qing Zhang
Chronic wounds have become an economic, social, and public health burden and need advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of chronic wounds because it contains an abundance of growth factors secreted by platelets. The exosomes derived from PRP (PRP-Exos) have been proven to encapsulate principal growth factors from platelets. This study is the first to show that these exosomes may exert the function of PRP. PRP-Exos can effectively induce proliferation and migration of endothelial cells and fibroblasts to improve angiogenesis and re-epithelialization in chronic wounds...
2017: Theranostics
https://www.readbyqxmd.com/read/28042260/effect-of-platelet-rich-plasma-concentrations-on-the-proliferation-of-periodontal-cells-an-in-vitro-study
#12
Sara Tavassoli-Hojjati, Mandana Sattari, Tayebeh Ghasemi, Rahil Ahmadi, Abbas Mashayekhi
OBJECTIVE: The purpose of this study was to evaluate the effect of different concentrations of platelet-rich plasma (PRP) on the proliferation of undifferentiated periodontal ligament (PDL) fibroblasts. MATERIALS AND METHODS: The undifferentiated PDL fibroblasts were obtained from two healthy human premolar teeth and cultured in Dulbecco's modified Eagle's medium. Cell wells were divided into five groups. Experimental groups received 0.1%, 5%, or 50% PRP; the positive and negative control groups were cultured in fetal bovine serum (FBS) 12% and in a medium without FBS 12%, respectively...
October 2016: European Journal of Dentistry
https://www.readbyqxmd.com/read/28033193/effect-of-platelet-rich-plasma-on-bone-grafting-of-alveolar-clefts
#13
Reiko Sakio, Yoshiaki Sakamoto, Hisao Ogata, Teruo Sakamoto, Takenobu Ishii, Kazuo Kishi
The purpose of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) on the absorption of the bone graft in the alveolar cleft.Twenty-nine patients with alveolar clefts in unilateral cleft lip were examined; 6 were the control group and received iliac cancellous bone and marrow grafts without PRP, while the remaining 23 comprised the PRP group and received grafts with PRP. Quantitative evaluation of remaining bone was made by the computer-aided engineering with multidetector row computed tomography at 1 month and 1 year after surgery...
December 28, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28028519/beneficial-effects-of-platelet-rich-plasma-on-improvement-of-pain-severity-and-physical-disability-in-patients-with-plantar-fasciitis-a-randomized-trial
#14
Babak Vahdatpour, Lida Kianimehr, Ahmad Moradi, Shila Haghighat
BACKGROUND: The present study aimed to clinically examine the effects of platelet-rich plasma (PRP) on improvement of plantar fasciitis and its related manifestations. PATIENTS AND METHODS: This single-blind randomized controlled trial was performed on 32 consecutive patients with the final diagnosis of plantar fasciitis that were randomly assigned to the case group (that received PRP, n = 16) and the control group (that received corticosteroid as methylprednisolone 1 ml plus lidocaine 1 ml, n = 16)...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28027872/the-effect-of-platelet-rich-plasma-on-achilles-tendon-healing-in-a-rabbit-model
#15
Masaki Takamura, Toshito Yasuda, Atsushi Nakano, Hiroaki Shima, Masashi Neo
OBJECTIVE: The aim of the present study was to evaluate the effects of PRP on Achilles tendon healing in rabbits during the inflammatory, proliferative, and remodeling phases by histological examination and quantitative assessments. METHODS: Fifty mature male Japanese albino rabbits with severed Achilles tendons were divided into two equal groups and treated with platelet-rich plasma (PRP) or left untreated. Tendon tissue was harvested at 1, 2, 3, 4, and 6 weeks after treatment, and sections were stained with hematoxylin-eosin and monoclonal antibodies against CD31 and type I collagen...
December 24, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28027451/the-use-of-platelet-rich-and-platelet-poor-plasma-to-enhance-differentiation-of-skeletal-myoblasts
#16
Olga Miroshnychenko, Wen-Teh Chang, Jason L Dragoo
BACKGROUND: Platelet-rich plasma (PRP) has been used to augment tissue repair and regeneration after musculoskeletal injury. However, there is increasing clinical evidence that PRP does not show a consistent clinical effect. Purpose/Hypothesis: This study aimed to compare the effects of the following non-neutrophil-containing (leukocyte-poor) plasma fractions on human skeletal muscle myoblast (HSMM) differentiation: (1) PRP, (2) modified PRP (Mod-PRP), in which transforming growth factor β1 (TGF-β1) and myostatin (MSTN) were depleted, and (3) platelet-poor plasma (PPP)...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28024792/effects-of-local-platelet-rich-plasma-injection-on-the-rate-of-orthodontic-tooth-movement-in-a-rat-model-a-histomorphometric-study
#17
Ayşegül Güleç, Banu Çakırer Bakkalbaşı, Alev Cumbul, Ünal Uslu, Burçin Alev, Ayşen Yarat
INTRODUCTION: The aims of this study were to determine the effects of different concentrations of platelet-rich plasma (PRP) on alveolar bone density and orthodontic tooth movement. METHODS: Seventy-six rats were divided into 2 groups: a moderate concentration PRP injection group (n = 38) and a high concentration PRP injection group (n = 38). In each group, 5 time points were studied: 3, 7, 14, 21, and 60 days. Before orthodontic mesialization of the maxillary first molars, moderate and high concentrations of PRP were injected on the right sides of the molar buccal sulcus, and the left sides served as the controls...
January 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28017682/cross-talking-between-lymphocytes-and-platelets-and-its-regulation-by-nitric-oxide-and-peroxynitrite-in-physiological-condition-and-endotoxemia
#18
Nádia J Almeida Cardelli, M Elisa Lopes-Pires, Pedro H L Bonfitto, Heloisa H Ferreira, Edson Antunes, Sisi Marcondes
AIMS: Cross-talk between platelets and lymphocytes may play a role in different pathological conditions like sepsis.This study aimed to investigate the effect of lymphocytes on platelet aggregation in lipopolysaccharide (LPS)-stimulated and non-stimulated cells. MAIN METHODS: Lymphocytes and platelet-rich plasma (PRP) were obtained from rat arterial blood. Platelets (1.2×10(8)platelets/ml) were incubated with lymphocytes (0.8×10(6)cells/ml) in the presence or not of LPS (100μg/ml), after which ADP (5μM)-induced platelet aggregation was carried out...
December 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/28012636/efficacy-of-platelet-rich-plasma-in-the-treatment-of-knee-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#19
Wen-Li Dai, Ai-Guo Zhou, Hua Zhang, Jian Zhang
PURPOSE: To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich plasma (PRP) injections for the treatment knee of osteoarthritis (OA). METHODS: We performed a systematic literature search in PubMed, Embase, Scopus, and the Cochrane database through April 2016 to identify Level I randomized controlled trials that evaluated the clinical efficacy of PRP versus control treatments for knee OA. The primary outcomes were Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores...
December 22, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28009403/ocular-pulse-amplitude-after-panretinal-photocoagulation-in-normotensive-eyes-with-proliferative-diabetic-retinopathy
#20
Marija M Bozic, Jelena B Karadzic, Igor M Kovacevic, Ivan S Marjanovic
PURPOSE: To assess the effect of panretinal laser photocoagulation on ocular pulse amplitude (OPA) in normotensive eyes with proliferative diabetic retinopathy. METHODS: Prospectively, we performed unilateral argon laser panretinal photocoagulation (PRP) in 30 patients with diabetes mellitus type II and previously untreated bilateral proliferative diabetic retinopathy. Before and 7 and 30 days after the treatment, OPA was measured using dynamic contour tonometer...
November 28, 2016: European Journal of Ophthalmology
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