Yongyi Zhang, Dan Yi, Quan Hong, Jiangbei Cao, Xiaodong Geng, Jinwei Liu, Chuang Xu, Mengyu Cao, Chao Chen, Shuaixuan Xu, Zhen Zhang, Molin Li, Yaqiong Zhu, Nan Peng
Peripheral nerve injury (PNI) remains a severe clinical problem with debilitating consequences. Mesenchymal stem cell (MSC)-based therapy is promising, but the problems of poor engraftment and insufficient neurotrophic effects need to be overcome. Herein, we isolated platelet-rich plasma-derived exosomes (PRP-Exos), which contain abundant bioactive molecules, and investigated their potential to increase the regenerative capacity of MSCs. We observed that PRP-Exos significantly increased MSC proliferation, viability, and mobility, decreased MSC apoptosis under stress, maintained MSC stemness, and attenuated MSC senescence...
January 29, 2024: Journal of Controlled Release