keyword
https://read.qxmd.com/read/38370486/role-of-platelet-rich-plasma-in-pelvic-floor-disorders-a-systematic-review
#21
REVIEW
Eighty Mardiyan Kurniawati, Nur Anisah Rahmawati, Gatut Hardianto, Hari Paraton, Tri Hastono Setyo Hadi
BACKGROUND: Management for pelvic floor disorders needs to be improved. Platelet-rich plasma (PRP) offers an innovative treatment in general medical care to promote cell regeneration. OBJECTIVE: This review aims to investigate the role of PRP in pelvic floor disorders. MATERIALS AND METHODS: 6 international databases were accessed using several keywords namely PubMed, Science Direct, Cochrane Library, ProQuest, Google Scholar, and Scopus. The inclusion criteria were articles written in English, published in 10-yr period from 2012 until 2022, and investigated the relevant topic...
December 2023: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38368520/effectiveness-of-autologous-platelet-rich-plasma-therapy-in-women-with-repeated-implantation-failure-a-randomized-clinical-trial
#22
JOURNAL ARTICLE
Maryam Eftekhar, Nosrat Neghab, Parisa Khani
BACKGROUND: Platelet-rich plasma (PRP) therapy has been shown to enhance tissue regeneration by expressing several cytokines and growth factors (GFs). This study investigated the effect of intrauterine infusion of PRP as a noninvasive autologous GF on pregnancy outcomes in women with repeated implantation failure. MATERIALS AND METHODS: This randomized clinical trial was conducted to compare the pregnancy rates between two groups of women who were candidates for the frozen-thawed embryo transfer with a history of two or more implantation failures...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38348990/experience-in-the-use-of-endovenous-methods-and-cell-technologies-in-the-treatment-of-patients-with-chronic-venous-insufficiency-c6
#23
JOURNAL ARTICLE
Sergii Savoliuk, Andrii Dembitskyi
<b><br>Introduction:</b> Severe forms of chronic venous insufficiency (CVI) CEAP C3-C6 occur in 17-20% of all CVI cases among adults.</br> <b><br>Aim:</b> The aim of this study was to compare the standard treatment of CVI C6 with endovenous methods and cellular technologies.</br> <b><br>Materials and methods:</b> Group I consisted of 28 patients with trophic ulceration treated using modern wound coverings, cell technologies and minimally invasive operations...
October 13, 2023: Polski Przeglad Chirurgiczny
https://read.qxmd.com/read/38344289/engineered-three-dimensional-bioactive-scaffold-for-enhanced-bone-regeneration-through-modulating-transplanted-adipose-derived-mesenchymal-stem-cell-and-stimulating-angiogenesis
#24
JOURNAL ARTICLE
Gan Wang, Yutao Cui, Yi Leng, Shouye Sun, Baoming Yuan, He Liu, Chuangang Peng, Dankai Wu
Titanium alloy materials are commonly used in orthopedic clinical treatments. However, conventional titanium implants usually lead to insufficient bone regeneration and integration because of mismatched biomechanics and poor bioactivities. To tackle these challenges, a porous titanium alloy scaffold with suitable mechanical properties was prepared using three-dimensional (3D) printing, and then an adipose-derived mesenchymal stem cell (ADSC) loaded platelet-rich plasma (PRP) gel was placed into the pores of the porous scaffold to construct a bioactive scaffold with dual functions of enhancing angiogenesis and osteogenesis...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38324593/not-all-platelet-rich-plasma-are-created-equal
#25
JOURNAL ARTICLE
Manuel Muñoz Cantero
PURPOSE OF REVIEW: This review aims to elucidate potential variations in clinical outcomes resulting from the use of different types of platelet-rich plasma (PRPs) in reproductive medicine. It seeks to explore the reasons behind the diverse results reported in various studies and assess the general features distinguishing different PRP formulations. RECENT FINDINGS: PRPs have found applications across diverse medical fields, generating controversy due to the variability in outcomes...
February 6, 2024: Current Opinion in Obstetrics & Gynecology
https://read.qxmd.com/read/38322082/evaluation-of-the-use-of-highly-concentrated-autologous-platelet-rich-plasma-and-platelet-rich-fibrin-membrane-to-improve-the-outcome-in-the-management-of-severe-dry-eye-disease-corneal-neurotrophic-ulcer-and-corneal-burn
#26
JOURNAL ARTICLE
Aaliouet Hassan, Alain Telandro, Abouddihaj Barguigua, Mustafa Baba, Norbert Körber
INTRODUCTION: The aim of this study was to evaluate the use of highly concentrated platelet-rich plasma (PRP) subconjunctival injections, in combination with eye drops (eye PRP, or E-PRP), in treating dry eye disease (DED) and the use of platelet-rich fibrin (PRF) membrane in treating corneal burns and neurotrophic ulcers for the restoration of the homeostasis of the tear film and the morphology and function of the cornea. METHODS: We studied 16 patients (n=32 eyes) with severe DED...
January 2024: Curēus
https://read.qxmd.com/read/38313640/inverse-relationship-between-platelet-akt-activity-and-hippocampal-atrophy-a-pilot-case-control-study-in-patients-with-diabetes-mellitus
#27
JOURNAL ARTICLE
Haruhiko Tokuda, Takamitsu Hori, Daisuke Mizutani, Tomoyuki Hioki, Kumi Kojima, Takashi Onuma, Yukiko Enomoto, Tomoaki Doi, Rie Matsushima-Nishiwaki, Shinji Ogura, Hiroki Iida, Toru Iwama, Takashi Sakurai, Osamu Kozawa
BACKGROUND: Akt plays diverse roles in humans. It is involved in the pathogenesis of type 2 diabetes mellitus (T2DM), which is caused by insulin resistance. Akt also plays a vital role in human platelet activation. Furthermore, the hippocampus is closely associated with memory and learning, and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without dementia. AIM: To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM patients...
January 16, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38308245/effect-of-platelet-rich-plasma-injection-on-bone-formation-in-the-expanded-mid-palatal-suture-in-rabbits-a-randomized-controlled-animal-study
#28
RANDOMIZED CONTROLLED TRIAL
Sherief H Abdel-Haffiez, Nesma Mohamed Khalil
BACKGROUND: Mid-Palatal suture expansion needs long retention period due to delayed bone formation in the expanded suture. Platelet-rich plasma (PRP) is a concentrated source of growth factors which increase bone formation. The aim of this study was to evaluate the effect of PRP injection on bone formation in expanded mid palatal suture in rabbits. METHODS: In this prospective randomized controlled animal study, Twenty male rabbits (8-weeks-old) were subjected to mid-palatal expansion for 5 days...
February 2, 2024: BMC Oral Health
https://read.qxmd.com/read/38299120/advances-with-platelet-rich-plasma-for-bone-healing
#29
REVIEW
Blake M Bacevich, Richard David James Smith, Alec M Reihl, Augustus D Mazzocca, Ian D Hutchinson
Despite significant advances in the understanding and delivery of osteosynthesis, fracture non-union remains a challenging clinical problem in orthopaedic surgery. To bridge the gap, basic science characterization of fracture healing provides a platform to identify and target biological strategies to enhance fracture healing. Of immense interest, Platelet-rich plasma (PRP) is a point of care orthobiologic that has been extensively studied in bone and soft tissue healing given its relative ease of translation from the benchtop to the clinic...
2024: Biologics: Targets & Therapy
https://read.qxmd.com/read/38296448/editorial-commentary-platelet-rich-plasma-for-musculoskeletal-conditions-is-supported-by-a-large-number-of-clinical-studies-particularly-for-knee-osteoarthritis
#30
EDITORIAL
Erik Hohmann
Platelet-rich plasma (PRP) represents a biological treatment for various musculoskeletal conditions. Over the past 20 years, publications regarding the treatment of orthopaedic conditions with PRP have shown a 4-fold increase. Several systematic reviews and meta-analyses have demonstrated that PRP is effective and often superior to other treatment modalities. However, the value of these studies is somehow limited as high risk of bias, study heterogeneity, and low levels of certainty compromise the validity of their conclusions...
February 2024: Arthroscopy
https://read.qxmd.com/read/38296140/cord-blood-platelet-rich-plasma-prp-as-a-potential-alternative-to-autologous-prp-for-allogenic-preparation-and-regenerative-applications
#31
JOURNAL ARTICLE
Rajesh Mani, Purandhi Roopmani, Jayakumar Rajendran, Sradhanjali Maharana, Jyotsnendu Giri
As an abundant supplier of growth factors, chemokines and other bioactive molecules, platelet rich plasma (PRP) become a leading therapy for tissue regeneration. The PRP therapy is an inexpensive and feasible source of growth factor compared to commercial products however, the better source of platelets is the major challenge. Many researchers are skeptical about cord blood as an alternative source for the allogenic preparation of PRP. In the present study, we have compared adult peripheral and cord blood PRP for their regenerative capacity and immuno-modulatory nature...
January 29, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38285989/enhanced-diabetic-rat-wound-healing-by-platelet-rich-plasma-adhesion-zwitterionic-hydrogel
#32
JOURNAL ARTICLE
Nan-Chieh Huang, Nien-Chi Huang, Lan-Ya Kang, Pai-Shan Hsieh, Lien-Guo Dai, Niann-Tzyy Dai, Chun-Jen Huang
BACKGROUND: The skin is the largest organ in the human body and serves as a barrier for protective, immune, and sensory functions. Continuous and permanent exposure to the external environment results in different levels of skin and extracellular matrix damage. During skin wound healing, the use of good dressings and addition of growth factors to the wound site can effectively modulate the rate of wound healing. A dressing containing bioactive substances can absorb wound exudates and reduce adhesion between the wound and dressing, whereas growth factors, cytokines, and signaling factors can promote cell motility and proliferation...
January 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38280991/the-value-of-intraovarian-autologous-platelet-rich-plasma-in-women-with-poor-ovarian-reserve-or-ovarian-insufficiency-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Ahmed M Maged, Reham A Mohsen, Noha Salah, Wael S Ragab
OBJECTIVES: To assess the value of intraovarian PRP in women with low ovarian reserve. SEARCH STRATEGY: Screening of databases from inception to January 2023 using the keywords related to "Platelet-rich plasma" AND "poor ovarian reserve" OR "ovarian failure". SELECTION CRITERIA: Fourteen studies (1632 participants) were included, 10 included women with POR, 1 included women with POI and 3 included both POR and POI women. DATA COLLECTION AND ANALYSIS: Extracted data included study settings, design, sample size, population characteristics, volume, timing and preparation of PRP administration, and outcome parameters...
January 27, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38253204/platelet-rich-plasma-derived-exosomes-boost-mesenchymal-stem-cells-to-promote-peripheral-nerve-regeneration
#34
JOURNAL ARTICLE
Yongyi Zhang, Dan Yi, Quan Hong, Jiangbei Cao, Xiaodong Geng, Jinwei Liu, Chuang Xu, Mengyu Cao, Chao Chen, Shuaixuan Xu, Zhen Zhang, Molin Li, Yaqiong Zhu, Nan Peng
Peripheral nerve injury (PNI) remains a severe clinical problem with debilitating consequences. Mesenchymal stem cell (MSC)-based therapy is promising, but the problems of poor engraftment and insufficient neurotrophic effects need to be overcome. Herein, we isolated platelet-rich plasma-derived exosomes (PRP-Exos), which contain abundant bioactive molecules, and investigated their potential to increase the regenerative capacity of MSCs. We observed that PRP-Exos significantly increased MSC proliferation, viability, and mobility, decreased MSC apoptosis under stress, maintained MSC stemness, and attenuated MSC senescence...
January 29, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38236257/uncorking-the-central-bottleneck-even-novel-tasks-can-be-performed-automatically
#35
JOURNAL ARTICLE
Morgan Lyphout-Spitz, François Maquestiaux, Eric Ruthruff, Steeven Chaloyard
Can people perform two novel tasks in parallel? Available evidence and prevailing theories overwhelmingly indicate that the answer is no, due to stubborn capacity limitations in central stages (e.g., a central bottleneck). Here we propose a new hypothesis, which suggests otherwise: people are capable of fully parallel central processing (i.e., bypassing the central bottleneck), yet often fail to do so, mainly due to preparation neglect. This preparation-neglect hypothesis was evaluated in four dual-task experiments pairing novel tasks (Task 1 and Task 2) using arbitrary stimulus-response mappings...
January 2024: Journal of Experimental Psychology. Human Perception and Performance
https://read.qxmd.com/read/38234679/long-term-improvement-of-knee-osteoarthritis-after-injection-of-single-high-very-high-volume-of-very-pure-prp-a-retrospective-analysis-of-patients-optimally-managed-in-dedicated-centers
#36
JOURNAL ARTICLE
Didier Prost, Thomas Bardot, Alexandre Baud, Anthony Calvo, Stephane Aumont, Herve Collado, Julien Borne, Olivier Rajon, Antoine Ponsot, Alexandra Malaterre, Yannis Dahak, Guy Magalon, Florence Sabatier, Jeremy Magalon
INTRODUCTION: PRP is gaining increasing interest for pain relief and improvement of joint function in patients with knee osteoarthritis (KOA) but practices and results remain heterogeneous limiting its adoption as standard of care. Current international recommendations are to collect real-life evidence of efficacy with a systematic monitoring of PRP quality and patients' outcomes. We aimed to analyze the response of patients presenting KOA and treated with standardized PRP injection in routine care...
March 2024: Regenerative Therapy
https://read.qxmd.com/read/38229261/platelet-rich-plasma-does-not-accelerate-the-healing-of-damaged-muscle-following-muscle-strain
#37
JOURNAL ARTICLE
Hiroyori Fusagawa, Takashi Yamada, Tatsuya Sato, Yuki Ashida, Atsushi Teramoto, Hiroyuki Takashima, Azuma Naito, Nao Tokuda, Nao Yamauchi, Nobutoshi Ichise, Izaya Ogon, Toshihiko Yamashita, Noritsugu Tohse
Although platelet-rich plasma (PRP) has been widely used regardless of the severity of muscle strain, there have been very few basic studies in which its effects on muscle injury were examined by using models that accurately mimic the clinical muscle strain injury process. Therefore, the aim of this study was to confirm by physiological and structural analyses whether PRP purified by a general preparation method has a muscle healing effect on muscle damage caused by eccentric contraction (ECC). Male Wistar rats were subjected to muscle injury induced by ECC in bilateral plantar flexor muscles using electrical stimulation and an automatically dorsiflexing footplate...
January 16, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38217970/using-analytical-quality-by-design-to-improve-analytical-method-development-in-vaccines-quality-control-application-to-an-optimized-quantitative-high-performance-anion-exchange-chromatographic-method
#38
JOURNAL ARTICLE
Isabelle Moineau, Véronique Chambon, Céline Perret, Luce Gouit, Isabelle Zamora, Mannaig Macumi, Stéphanie Fertier-Prizzon, Olivier Pitiot
Analytical quality by design (AQbD) is an enhanced approach for the development of analytical methods. AQbD has received much industrial interest, being the subject of several recently published draft guidelines. This article demonstrates the application of AQbD to determine the quantity of non-adsorbed polysaccharide polyribosyl ribitol phosphate (PRP) and percentage of depolymerized PRP in a commercial hexavalent liquid vaccine, and establishment of an analytical control strategy (ACS). The quantification method developed is high-performance anion-exchange chromatography (HPAEC) with pulsed amperometric detection, preceded by ultracentrifugation (sample preparation) for separation of the depolymerized polysaccharide from the native adsorbed polysaccharide...
December 5, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38217531/platelet-rich-plasma-in-orthopedics-bridging-innovation-and-clinical-applications-for-bone-repair
#39
REVIEW
Liangbo Zhu, Ping Li, Yuhong Qin, Baowei Xiao, Junning Li, Wenhua Xu, Bo Yu
In the burgeoning domain of orthopedic therapeutic research, Platelet-Rich Plasma (PRP) has firmly established its position, transforming paradigms ranging from tissue regeneration to the management of chondral lesions. This review delves into PRP's recent integrations with cutting-edge interventions such as 3D-printed scaffolds, its role in bone and cartilage defect management, and its enhanced efficacy when combined with molecules like Kartogenin (KGN) for fibrocartilage zone repair. Significant attention is paid to tissue engineering for meniscal interventions, where a combination of KGN, PRP, and bone marrow-derived mesenchymal stem cells are under exploration...
2024: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/38200124/dual-network-hydrogels-based-on-prp-and-sa-promote-the-retention-rate-and-vascularization-of-transplanted-fat
#40
JOURNAL ARTICLE
Huichen Li, Han Peng, Jiezhang Tang, Mengmeng Hou, Baoyan Liang, Yun Zhu, Yi Cheng, Lihua Yang, Zhaoxiang Zhang, Chenggang Yi
BACKGROUND: Autologous adipose tissue often experiences ischemia and hypoxia after transplantation, leading to low retention rates and unstable operative impacts due to necrotic absorption. Platelet-rich plasma (PRP) can enhance fat regeneration and increase the fat retention rate after transplantation. However, the quick release of growth factors (GFs) in PRP decreases therapeutic efficiency. This study aimed to achieve a slow release of PRP to promote fat retention. METHODS: We prepared a dual-network hydrogel (DN gel) based on FDA-approved PRP and sodium alginate (SA) through a simple "one-step" activation process...
January 10, 2024: Aesthetic Plastic Surgery
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