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https://www.readbyqxmd.com/read/27927587/estimated-gfr-before-and-after-bariatric-surgery-in-ckd
#1
Talha H Imam, Heidi Fischer, Bocheng Jing, Raoul Burchette, Shayna Henry, Stephen F DeRose, Karen J Coleman
BACKGROUND: Several reviews have recently detailed the beneficial effects of weight loss surgery for kidney function. However, these studies have a number of limitations, including small sample size, few done in chronic kidney disease (CKD) stages 3 and 4, and many not including the main bariatric surgery procedures used in the United States today. STUDY DESIGN: This was an observational retrospective cohort study comparing propensity score-matched bariatric surgery patients and nonsurgery control patients who were referred for, but did not have, surgery...
December 4, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27919596/chimeric-anterolateral-thigh-free-flap-for-reconstruction-of-complex-cranio-orbito-facial-defects-after-skull-base-cancers-resection
#2
Mario Cherubino, Mario Turri-Zanoni, Paolo Battaglia, Marco Giudice, Igor Pellegatta, Federico Tamborini, Francesca Maggiulli, Luca Guzzetti, Danilo Di Giovanna, Maurizio Bignami, Carolina Calati, Paolo Castelnuovo, Luigi Valdatta
Complex cranio-orbito-facial defects after skull base cancers resection entail a functional and esthetic reconstruction. The introduction of endoscopic assisted techniques for excision surgery with the advances in reconstructive surgery and anesthesiology allowed to improve the management of such critical patients. We report a series of chimeric anterolateral thigh (ALT) flaps used to reconstruct complex cranio-orbital-facial defects after skull base surgery. A retrospective review of patients that underwent cranio-orbito-facial reconstruction using a chimeric ALT flap from March 2013 to October 2015 at a single tertiary care referral Institute was performed...
November 2, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27896146/determination-of-functional-prognosis-in-hospitalized-patients-following-an-intensive-care-admission
#3
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes
AIM: To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission. METHODS: Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale)...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27853049/comparison-of-two-different-regimens-of-intravenous-methylprednisolone-for-patients-with-moderate-to-severe-and-active-graves-ophthalmopathy-a-prospective-randomized-controlled-trial
#4
Yebing He, Ketao Mu, Rong Liu, Jing Zhang, Nan Xiang
The intravenous methylprednisolone (iv MP) strategy for Graves' ophthalmopathy (GO) and evaluation of its activity against the disease warrants further exploration. A prospective randomized controlled trial for 3 months was performed in a tertiary referral teaching hospital to compare the efficacy and safety of two different regimens of iv MP, and determine the value of clinical activity score (CAS) and T2 relaxation time (T2RTs) and areas of extraocular muscles (EOMs) by magnetic resonance imaging for diagnosis of active GO...
November 16, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27843860/rhabdomyolysis-in-dak-bum-devotees-a-case-series
#5
Sonia Singh, Pankaj Hans
INTRODUCTION: India is a land of culture and heritage always known for its rituals. The devotees offer their prayers in the form of fasting, sacrifices and many other difficult ways to please Almighty! While doing so they often endanger their lives. Rhabdomyolysis, in a particular group of devotees of Bihar/Jharkhand known as Dak-Bum, is a life-threatening clinical entity which occurs in these devotees who travel a long distance in a short period in a fasting state. Rhabdomyolysis detected by myoglobinuria can lead to acute kidney injury and mortality...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27829531/patterns-of-referral-to-radiation-oncology-among-patients-with-bladder-cancer-a-population-based-study
#6
J S Quirt, D R Siemens, K Zaza, W J Mackillop, C M Booth
AIMS: Radical radiotherapy is a reasonable alternative to cystectomy for some patients with invasive bladder cancer, and postoperative radiotherapy may be indicated in patients at high risk of local recurrence. Here we describe pre- and postoperative radiation oncology consultation among patients with bladder cancer in Ontario. MATERIALS AND METHODS: Records of radiotherapy and surgery were linked to the Ontario Cancer Registry (OCR) to identify all patients who received treatment with curative intent for bladder cancer between 1994 and 2008...
November 6, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27817933/morcellation-worsens-survival-outcomes-in-patients-with-undiagnosed-uterine-leiomyosarcomas-a-retrospective-mito-group-study
#7
Francesco Raspagliesi, Giuseppa Maltese, Giorgio Bogani, Giovanni Fucà, Stefano Lepori, Pierandrea De Iaco, Myriam Perrone, Giovanni Scambia, Gennaro Cormio, Stefano Bogliolo, Alice Bergamini, Giuseppe Bifulco, Paolo Giovanni Casali, Domenica Lorusso
OBJECTIVE: To investigate the impact of morcellation on survival outcomes of patients affected by undiagnosed uterine sarcoma. METHODS: This is a retrospective study performed in 8 referral centers of MITO group. Data of women undergoing morcellation for apparent benign uterine myomas who were ultimately diagnosed with stage I uterine sarcoma on final pathology were compared with data of women who did not undergo morcellation. Uterine sarcoma included: leiomyosarcomas (LMS), smooth muscle tumors of uncertain malignant potential (STUMP), low-grade endometrial stromal sarcomas (LG-ESS) and undifferentiated uterine sarcomas (UUS)...
November 4, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27793165/surviving-critical-illness-what-is-next-an-expert-consensus-statement-on-physical-rehabilitation-after-hospital-discharge
#8
M E Major, R Kwakman, M E Kho, B Connolly, D McWilliams, L Denehy, S Hanekom, S Patman, R Gosselink, C Jones, F Nollet, D M Needham, R H H Engelbert, M van der Schaaf
BACKGROUND: The study objective was to obtain consensus on physical therapy (PT) in the rehabilitation of critical illness survivors after hospital discharge. Research questions were: what are PT goals, what are recommended measurement tools, and what constitutes an optimal PT intervention for survivors of critical illness? METHODS: A Delphi consensus study was conducted. Panelists were included based on relevant fields of expertise, years of clinical experience, and publication record...
October 29, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27716425/flank-pseudohernia-following-posterior-rib-fracture-a-case-report
#9
Adam M Butensky, Leah P Gruss, Zachary L Gleit
BACKGROUND: A pseudohernia is an abdominal wall bulge that may be mistaken for a hernia but that lacks the disruption of the abdominal wall that characterizes a hernia. Thus, the natural history and treatment of this condition differ from those of a hernia. This is the first report of a pseudohernia due to cough-associated rib fracture. CASE PRESENTATION: A case of pseudohernia due to fractures of the 10(th) and 11(th) ribs in a 68-year-old white woman is presented...
October 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27716209/effects-of-testosterone-treatment-on-body-fat-and-lean-mass-in-obese-men-on-a-hypocaloric-diet-a-randomised-controlled-trial
#10
Mark Ng Tang Fui, Luke A Prendergast, Philippe Dupuis, Manjri Raval, Boyd J Strauss, Jeffrey D Zajac, Mathis Grossmann
BACKGROUND: Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass. METHODS: We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m(2)) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls)...
October 7, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27689068/incidental-prostate-cancer-diagnosed-at-radical-cystoprostatectomy-for-bladder-cancer-disease-specific-outcomes-and-survival
#11
Joshua B Kaelberer, Michael A O'Donnell, Darrion L Mitchell, Anthony N Snow, Sarah L Mott, John M Buatti, Mark C Smith, John M Watkins
BACKGROUND: The current standard of care for men with muscle-invasive bladder cancer is radical cystoprostatectomy (RCP). One-third of RCP specimens demonstrate incidental prostate cancer, primarily reported in small series with limited follow-up. The aim of this study is to report mature outcomes, including patterns of failure and disease-specific recurrence rates, and survival, for a large cohort of men with incidental prostate cancer at RCP performed at a tertiary referral center. METHODS: This retrospective study describes cancer control and survival rates for men who underwent RCP for bladder cancer and were found incidentally to have prostate cancer...
September 2016: Prostate International
https://www.readbyqxmd.com/read/27685877/the-efficacy-of-bronchial-thermoplasty-for-severe-persistent-asthma-the-first-national-experience
#12
D C Watchorn, A Sahadevan, J J Egan, S J Lane
There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in severe persistent asthma in other populations. Seven patients have completed bronchial thermoplasty at a tertiary referral centre in Ireland. Asthma Control Test scores and data on hospitalisations, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and peak expiratory flow rate (PEFR) were compared one year before and one year post treatment...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27678142/does-the-vaginal-wall-become-thinner-as-prolapse-grade-increases
#13
Rhiannon Bray, Alex Derpapas, Ruwan Fernando, Vik Khullar, Demetri C Panayi
INTRODUCTION AND HYPOTHESIS: The pathophysiology of prolapse is not well understood. However, two main theories predominate: either the fibromuscular layer of the vagina develops a defect/tears away from its supports, or its tissues are stretched and attenuated. The aim of this study was to assess how vaginal wall thickness (VWT) is related to vaginal prolapse. METHODS: The study group comprised 243 women with symptomatic prolapse recruited from the Outpatient Department of a tertiary referral centre for urogynaecology...
September 27, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27669823/recruitment-of-older-adults-with-type-2-diabetes-into-a-community-based-exercise-and-nutrition-randomised-controlled-trial
#14
Eliza G Miller, Caryl A Nowson, David W Dunstan, Deborah A Kerr, Vicky Solah, David Menzies, Robin M Daly
BACKGROUND: Recruitment of participants into long-term community-based lifestyle intervention trials, particularly adults with a chronic disease, is often slow and challenging. Currently there is limited data on successful recruitment strategies suitable for older adults with type 2 diabetes into community-based exercise and nutrition programs, and no information on cost estimates associated with such recruitment. The aim of this report is to describe the recruitment strategies used and the success of each approach in recruiting older adults with type 2 diabetes into a 6-month community-based exercise and nutritional supplementation randomised controlled trial (RCT)...
September 26, 2016: Trials
https://www.readbyqxmd.com/read/27640448/managing-adverse-events-associated-with-vismodegib-in-the-treatment-of-basal-cell-carcinoma
#15
Kate Fife, Robert Herd, Susan Lalondrelle, Ruth Plummer, Amy Strong, Sarah Jones, John T Lear
Basal cell carcinomas are the most common form of skin cancer. Some develop into advanced cases not suitable for standard therapy. Vismodegib is the first-in-class oral hedgehog pathway inhibitor (which is dysregulated in 90% of basal cell carcinomas), and has demonstrated efficacy for advanced disease in clinical trials. An UK expert panel met to discuss management strategies for adverse events associated with vismodegib (most commonly taste disturbances, muscle cramps and alopecia). Managing patient expectations and implementing treatment breaks were considered important strategies...
January 2017: Future Oncology
https://www.readbyqxmd.com/read/27624510/phosphodiesterase-5-inhibitor-use-an-under-reported-cause-of%C3%A2-profuse-nasal-bleeding
#16
Petros V Vlastarakos, Thomas P Nikolopoulos
BACKGROUND: Phosphodiesterase-5 (PDE-5) inhibitors enhance penile erection and have gained popularity not only for erectile dysfunction, but also in recreational settings. Nevertheless, adverse effects have been associated with their use, with nasal bleeding among them. PDE-5 inhibitor action is materialized through the inhibition of the cyclic guanosine monophosphate (cGMP) enzyme. cGMP is present at several sites of the human body in addition to the corpus cavernosum, leading to the adverse effects associated with its nonselective inhibition...
November 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27606474/thenar-muscles-h-reflex-in-patients-with-fibromyalgia-a-case-control-study
#17
K Azma, S A Raeissadat, A Hosseini, H Mahmoudi, M Sepehrian, Z Salehi
OBJECTIVE: To delineate H-reflex parameters and specify the diagnostic accuracy measures of thenar muscle H-reflex in Fibromyalgia (FM). METHODS: The study was a cross sectional study performed on 30 subjects with FM and 30 healthy volunteers in two major referral hospitals. We recorded the number of obtainable thenar H-reflexes and their minimum latency, threshold and amplitude in each group. RESULTS: There was a significantly more chance to elicit the H-reflex in patients with FM...
April 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27595416/closing-the-gender-gap-can-we-improve-bladder-cancer-survival-in-women-a-systematic-review-of-diagnosis-treatment-and-outcomes
#18
Frances Burge, Roger Kockelbergh
INTRODUCTION: Despite recent attention, there are no gender specific guidelines to address the disparity in bladder cancer survival between the sexes. The focus of this review was to identify areas of clinical practice that may influence bladder cancer outcomes and to provide evidence-based recommendations to improve bladder cancer survival in women. METHOD: A systematic search of MEDLINE was conducted to identify studies related to referral, diagnosis, treatment and outcomes of patients with bladder cancer with particular reference to gender differences...
2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27583476/effect-of-linagliptin-on-vascular-function-a-randomized-placebo-controlled-study
#19
Dimitrios Baltzis, Jody R Dushay, Jordan Loader, Jim Wu, Robert L Greenman, Matthieu Roustit, Aristidis Veves
CONTEXT: The dipeptidyl peptidase-4 inhibitor, linagliptin, possesses pleiotropic vasodilatory, antioxidant, and anti-inflammatory properties in animals, independent of its glucose-lowering properties. Although large, randomized clinical trials are being conducted to better evaluate the efficacy and safety of linagliptin on cardiovascular outcomes, little is known about its effects on vascular function in humans. OBJECTIVE: This study sought to evaluate the effect of linagliptin on surrogates of vascular and mitochondrial function...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27567595/prevalence-and-bother-of-patient-reported-lower-urinary-tract-symptoms-in-the-muscular-dystrophies
#20
Laura A Bertrand, Eric J Askeland, Katherine D Mathews, Bradley A Erickson, Christopher S Cooper
INTRODUCTION: Duchenne muscular dystrophy (DMD) and the less severe Becker muscular dystrophy (BMD) are characterized by progressive muscle weakness and eventual loss of ambulation, and result from mutations in the dystrophin gene. Dystrophin is essential for skeletal muscle functioning but its role in smooth muscle function is not as well established. In a retrospective review, our group previously demonstrated that roughly half of these patients have at least one documented urologic diagnosis, most commonly being lower urinary tract symptoms (LUTS) and nephrolithiasis...
July 12, 2016: Journal of Pediatric Urology
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