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https://www.readbyqxmd.com/read/28937617/comparison-of-patterns-of-use-of-unrecorded-and-recorded-spirits-survey-of-adult-drinkers-in-rural-central-china
#1
Shiqing Wei, Ping Yin, Ian M Newman, Ling Qian, Duane F Shell, Lok-Wa Yuen
About 70% of the beverage alcohol consumed in China annually is spirits. Recorded spirits make up most spirit consumption, but about 25% of total alcohol consumption (1.7 L pure alcohol per capita annually) is unrecorded spirits (bai jiu), either homemade or made in unregulated distilleries. In some parts of China, the consumption of unrecorded spirits is higher than average. This paper compares the patterns of use of unrecorded distilled spirits and recorded distilled spirits among rural residents in Central China...
September 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28937446/costs-of-robotic-assisted-versus-traditional-laparoscopy-in-endometrial-cancer
#2
Riikka-Liisa K Vuorinen, Minna M Mäenpää, Kari Nieminen, Eija I Tomás, Tiina H Luukkaala, Anssi Auvinen, Johanna U Mäenpää
OBJECTIVES: The purpose of this study was to compare the costs of traditional laparoscopy and robotic-assisted laparoscopy in the treatment of endometrial cancer. METHODS AND MATERIALS: A total of 101 patients with endometrial cancer were randomized to the study and operated on starting from 2010 until 2013, at the Department of Obstetrics and Gynecology of Tampere University Hospital, Tampere, Finland. Costs were calculated based on internal accounting, hospital database, and purchase prices and were compared using intention-to-treat analysis...
October 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28935831/anti-inflammatory-approaches-to-ischaemic-stroke-prevention
#3
REVIEW
Peter J Kelly, Sean Murphy, Sarah Coveney, Francisco Purroy, Robin Lemmens, Georgios Tsivgoulis, Chris Price
Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the 'inflammation hypothesis' in coronary disease and stroke.Trial registration number CONVINCE trial ClinicalTrials...
September 21, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28935360/when-guidelines-conflict-a-case-study-of-mammography-screening-initiation-in-the-1990s
#4
Mireille Jacobson, Srikanth Kadiyala
BACKGROUND: Cancer screening guidelines communicate important information to patients and physicians regarding the costs and benefits of screening. Currently, guideline recommendations from major organizations conflict regarding the age of mammography screening initiation. To understand current and future U.S. mammography screening patterns we study age-mammography patterns from the 1990s, another period of conflicting guideline recommendations. METHODS: We examine mammography use rates by single year of age to understand compliance with guideline-recommended initiation ages in the 1990s...
September 18, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28935190/a-roadmap-for-cost-of-goods-planning-to-guide-economic-production-of-cell-therapy-products
#5
REVIEW
Yonatan Y Lipsitz, William D Milligan, Ian Fitzpatrick, Evelien Stalmeijer, Suzanne S Farid, Kah Yong Tan, David Smith, Robert Perry, Jessica Carmen, Allen Chen, Charles Mooney, John Fink
Cell therapy products are frequently developed and produced without incorporating cost considerations into process development, contributing to prohibitively costly products. Herein we contextualize individual process development decisions within a broad framework for cost-efficient therapeutic manufacturing. This roadmap guides the analysis of cost of goods (COG) arising from tissue procurement, material acquisition, facility operation, production, and storage. We present the specific COG considerations related to each of these elements as identified through a 2013 International Society for Cellular Therapy COG survey, highlighting the differences between autologous and allogeneic products...
September 18, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28934680/a-phase-1-study-of-the-janus-kinase-2-jak2-v617f-inhibitor-gandotinib-ly2784544-in-patients-with-primary-myelofibrosis-polycythemia-vera-and-essential-thrombocythemia
#6
Srdan Verstovsek, Ruben A Mesa, Mohamed E Salama, Li Li, Celine Pitou, Fabio P Nunes, Gregory L Price, Jennifer L Giles, Deborah N D'Souza, Richard A Walgren, Josef T Prchal
Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2(V617F) mutation. The study had a standard 3+3 dose-escalation design to define the maximum-tolerated dose. Primary objectives were to determine safety, tolerability, and recommended oral daily dose of gandotinib for patients with JAK2(V617F)-positive myelofibrosis, essential thrombocythemia, or polycythemia vera...
August 31, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28934516/large-scale-analysis-evaluating-regional-variability-in-the-request-of-laboratory-tests-in-primary-care-and-its-potential-economic-impact
#7
Maria Salinas, Maite López-Garrigós, Emilio Flores, Carlos Leiva-Salinas
Objective: To compare the ratios of requests of aspartate aminotransferase (AST) to alanine aminotransferase (ALT) and urea to creatinine (Crea); to investigate the variability among regions and to calculate the potential savings if a target is reached. Methods: Laboratories were invited to fill out a registration form on the number of AST, ALT, Urea and Crea requested in 2014, and to provide the reagent price of urea and AST. AST:ALT and Urea:Crea were calculated and compared; also compared were potential savings if each laboratory would have reached the target...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934348/antimicrobial-resistance-in-clinical-escherichia-coli-isolates-from-poultry-and-livestock-china
#8
Afrah Kamal Yassin, Jiansen Gong, Patrick Kelly, Guangwu Lu, Luca Guardabassi, Lanjing Wei, Xiangan Han, Haixiang Qiu, Stuart Price, Darong Cheng, Chengming Wang
Poultry and livestock are the most important reservoirs for pathogenic Escherichia coli and use of antimicrobials in animal farming is considered the most important factor promoting the emergence, selection and dissemination of antimicrobial-resistant microorganisms. The aim of our study was to investigate antimicrobial resistance in E. coli isolated from food animals in Jiangsu, China. The disc diffusion method was used to determine susceptibility to 18 antimicrobial agents in 862 clinical isolates collected from chickens, ducks, pigs, and cows between 2004 and 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28933965/the-evidence-based-practitioner-applying-research-to-meet-client-needs-2017-by-catana-brown-233-pp-soft-cover-isbn-13-9780803643666-fa-davis-company-philadelphia-pa-price-59-95
#9
https://www.readbyqxmd.com/read/28933010/economic-evaluation-of-dupilumab-for-the-treatment-of-moderate-to-severe-atopic-dermatitis-in-adults
#10
Andreas Kuznik, Gaëlle Bégo-Le-Bagousse, Laurent Eckert, Abhijit Gadkari, Eric Simpson, Christopher N Graham, LaStella Miles, Vera Mastey, Puneet Mahajan, Sean D Sullivan
INTRODUCTION: Dupilumab significantly improves signs and symptoms of atopic dermatitis (AD), including pruritus, symptoms of anxiety and depression, and health-related quality of life versus placebo in adults with moderate-to-severe AD. Since the cost-effectiveness of dupilumab has not been evaluated, the objective of this analysis was to estimate a value-based price range in which dupilumab would be considered cost-effective compared with supportive care (SC) for treatment of moderate-to-severe AD in an adult population...
September 20, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28932889/behavioral-economic-analysis-of-the-effects-of-n-substituted-benztropine-analogs-on-cocaine-self-administration-in-rats
#11
Claudio Zanettini, Derek S Wilkinson, Jonathan L Katz
RATIONALE AND OBJECTIVES: Benztropine (BZT) analogs and other atypical dopamine uptake inhibitors selectively decrease cocaine self-administration at doses that do not affect responding maintained by other reinforcers. Those effects were further characterized in the current study using a behavioral economic assessment of how response requirement (price) affects reinforcers obtained (consumption) in rats. METHODS: Two groups of rats were trained to press levers with food (45-mg pellet) or cocaine (0...
September 21, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28932779/technoeconomic-assumptions-adopted-for-the-development-of-a-long-term-electricity-supply-model-for-cyprus
#12
Constantinos Taliotis, Emanuele Taibi, Mark Howells, Holger Rogner, Morgan Bazilian, Manuel Welsch
The generation mix of Cyprus has been dominated by oil products for decades. In order to conform with European Union and international legislation, a transformation of the supply system is called for. Energy system models can facilitate energy planning into the future, but a large volume of data is required to populate such models. The present data article provides information on key modelling assumptions and input data adopted with the aim of representing the electricity supply system of Cyprus in a separate research article...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28932740/tapping-the-vast-potential-of-the-data-deluge-in-small-scale-food-animal-production-businesses-challenges-to-near-real-time-data-analysis-and-interpretation
#13
Flavie Vial, Andrew Tedder
Food-animal production businesses are part of a data-driven ecosystem shaped by stringent requirements for traceability along the value chain and the expanding capabilities of connected products. Within this sector, the generation of animal health intelligence, in particular, in terms of antimicrobial usage, is hindered by the lack of a centralized framework for data storage and usage. In this Perspective, we delimit the 11 processes required for evidence-based decisions and explore processes 3 (digital data acquisition) to 10 (communication to decision-makers) in more depth...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28932212/comparative-genomics-of-burkholderia-singularis-sp-nov-a-low-g-c-content-free-living-bacterium-that-defies-taxonomic-dissection-of-the-genus-burkholderia
#14
Peter Vandamme, Charlotte Peeters, Birgit De Smet, Erin P Price, Derek S Sarovich, Deborah A Henry, Trevor J Hird, James E A Zlosnik, Mark Mayo, Jeffrey Warner, Anthony Baker, Bart J Currie, Aurélien Carlier
Four Burkholderia pseudomallei-like isolates of human clinical origin were examined by a polyphasic taxonomic approach that included comparative whole genome analyses. The results demonstrated that these isolates represent a rare and unusual, novel Burkholderia species for which we propose the name B. singularis. The type strain is LMG 28154(T) (=CCUG 65685(T)). Its genome sequence has an average mol% G+C content of 64.34%, which is considerably lower than that of other Burkholderia species. The reduced G+C content of strain LMG 28154(T) was characterized by a genome wide AT bias that was not due to reduced GC-biased gene conversion or reductive genome evolution, but might have been caused by an altered DNA base excision repair pathway...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28931379/the-effects-of-a-rise-in-cigarette-price-on-cigarette-consumption-tobacco-taxation-revenues-and-of-smoking-related-deaths-in-28-eu-countries-applying-threshold-regression-modelling
#15
Chun-Yuan Yeh, Christian Schafferer, Jie-Min Lee, Li-Ming Ho, Chi-Jung Hsieh
BACKGROUND: European Union public healthcare expenditure on treating smoking and attributable diseases is estimated at over €25bn annually. The reduction of tobacco consumption has thus become one of the major social policies of the EU. This study investigates the effects of price hikes on cigarette consumption, tobacco tax revenues and smoking-caused deaths in 28 EU countries. METHODS: Employing panel data for the years 2005 to 2014 from Euromonitor International, the World Bank and the World Health Organization, we used income as a threshold variable and applied threshold regression modelling to estimate the elasticity of cigarette prices and to simulate the effect of price fluctuations...
September 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28931029/screening-of-a-long-term-sample-set-reveals-two-ranavirus-lineages-in-british-herpetofauna
#16
Stephen J Price, Alexandra Wadia, Owen N Wright, William T M Leung, Andrew A Cunningham, Becki Lawson
Reports of severe disease outbreaks in amphibian communities in mainland Europe due to strains of the common midwife toad virus (CMTV)-like clade of Ranavirus are increasing and have created concern due to their considerable population impacts. In Great Britain, viruses in another clade of Ranavirus-frog virus 3 (FV3)-like-have caused marked declines of common frog (Rana temporaria) populations following likely recent virus introductions. The British public has been reporting mortality incidents to a citizen science project since 1992, with carcasses submitted for post-mortem examination, resulting in a long-term tissue archive spanning 25 years...
2017: PloS One
https://www.readbyqxmd.com/read/28930692/palbociclib-in-hormone-receptor-positive-advanced-breast-cancer-a-cost-utility-analysis
#17
J Raphael, J Helou, K I Pritchard, D M Naimark
INTRODUCTION: The addition of palbociclib to letrozole improves progression-free survival in the first-line treatment of hormone receptor positive advanced breast cancer (ABC). This study assesses the cost-utility of palbociclib from the Canadian healthcare payer perspective. METHODS: A probabilistic discrete event simulation (DES) model was developed and parameterised with data from the PALOMA 1 and 2 trials and other sources. The incremental cost per quality-adjusted life-month (QALM) gained for palbociclib was calculated...
September 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28930198/joint-decisions-on-production-and-pricing-with-strategic-consumers-for-green-crowdfunding-products
#18
Yuting Chen, Rong Zhang, Bin Liu
Green crowdfunding is developing as a novel and popular transaction method, which can largely improve the efficiency of raising initial funds and selling innovative green products or services. In this paper, we explore the creator's joint decisions regarding green crowdfunding products of different quality levels that can sufficiently satisfy consumer preferences. Firstly, considering the characteristics of a green crowdfunding product, we present four pricing strategies when substitutes exist. Then we propose the optimal pricing strategies to maximize the total profit for the creator under different circumstances, facing strategic and myopic consumers...
September 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28929943/formal-alternative-transportation-options-for-older-adults-an-assessment-of-need
#19
Joshua J Turner, Carolyn E Adams-Price, Lesley Strawderman
Although older adults are typically able to drive well into older adulthood, health and cognitive deficits can eventually make older motorists a danger to themselves and others. There is a need for increased senior-focused transportation options, yet implementation of such programs is problematic due to an uncertainty about which groups are in most need of services. This study measured the perceived need for formal alternative modes of transportation among older adults. Using data from a nationwide survey, this study applies the traditional factors of the Behavioral Model to measure the perceived need for formal transportation services among survey participants, while also examining the relationship between service awareness and perceived need for formal transportation services...
September 20, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28929871/japanese-healthcare-fostering-competition-and-controlling-costs
#20
James H Tiessen, Ken Kato
Japan's universal healthcare system is relatively inexpensive, provides accessible services, and was established nearly 10 years before Canada's. Two aspects of Japan's system are particularly interesting. The first is that there is active competition for patients between a variety of hospital providers, which can be privately or publicly owned. This competition is based on service quality because prices are set centrally. The second feature is that these prices are adjusted biannually by a National Council, the Chuikyo, that includes payers (employers), providers, and third-party experts in public negotiations...
July 2017: Healthcare Management Forum
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