keyword
https://read.qxmd.com/read/38540007/use-of-a-custom-made-patellar-groove-replacement-in-an-american-staffordshire-terrier-puppy-with-a-severe-bone-defect-in-the-femoral-trochlea-caused-by-hematogenous-osteomyelitis
#21
Enrico Panichi, Sara Sassaroli, Giorgio Maria Ciccarese, Valentina Riccio, Caterina Balestriere, Marco Barbaccia, Fulvio Cappellari, Ekaterina Burkhan, Angela Palumbo Piccionello
An 8-month-old male American Staffordshire terrier was referred for a no-weightbearing lameness of the right pelvic limb, hyperthermia, lethargy and inappetence. Two months before, endocarditis was diagnosed and treated in another veterinary hospital. Orthopedic, radiographic and tomographic examinations revealed a bone sequestrum of 4 × 1.4 cm and active periosteal reaction of the caudo-lateral cortical in the metaphysis and the distal third of the right femoral diaphysis, medullary osteolysis and interruption of the cranio-medial cortical profile, with involvement of the femoral trochlea leading to a secondary medial patella luxation...
March 15, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38539561/real-world-outcome-of-treatment-with-single-agent-ibrutinib-in-italian-patients-with-chronic-lymphocytic-leukemia-final-results-of-the-evidence-study
#22
JOURNAL ARTICLE
Francesca Romana Mauro, Potito Rosario Scalzulli, Lydia Scarfò, Carla Minoia, Roberta Murru, Paolo Sportoletti, Ferdinando Frigeri, Francesco Albano, Nicola Di Renzo, Alessandro Sanna, Luca Laurenti, Massimo Massaia, Ramona Cassin, Marta Coscia, Caterina Patti, Elsa Pennese, Agostino Tafuri, Annalisa Chiarenza, Piero Galieni, Omar Perbellini, Carmine Selleri, Catello Califano, Felicetto Ferrara, Antonio Cuneo, Marco Murineddu, Gaetano Palumbo, Ilaria Scortechini, Alessandra Tedeschi, Livio Trentin, Marzia Varettoni, Fabrizio Pane, Anna Marina Liberati, Francesco Merli, Lucia Morello, Gerardo Musuraca, Monica Tani, Adalberto Ibatici, Giulia Regazzoni, Michele Di Candia, Maria Palma, Danilo Arienti, Stefano Molica
Real-world data in clinical practice are needed to confirm the efficacy and safety that ibrutinib has demonstrated in clinical trials of patients with chronic lymphocytic leukemia (CLL). We described the real-world persistence rate, patterns of use, and clinical outcomes in 309 patients with CLL receiving single-agent ibrutinib in first line (1L, n = 118), 2L ( n = 127) and ≥3L ( n = 64) in the prospective, real-world, Italian EVIdeNCE study. After a median follow-up of 23.9 months, 29.8% of patients discontinued ibrutinib (1L: 24...
March 20, 2024: Cancers
https://read.qxmd.com/read/38539450/upper-tract-urothelial-cancer-guideline-of-guidelines
#23
REVIEW
Savio Domenico Pandolfo, Simone Cilio, Achille Aveta, Zhenjie Wu, Clara Cerrato, Luigi Napolitano, Francesco Lasorsa, Giuseppe Lucarelli, Paolo Verze, Salvatore Siracusano, Carmelo Quattrone, Matteo Ferro, Eugenio Bologna, Riccardo Campi, Francesco Del Giudice, Riccardo Bertolo, Daniele Amparore, Sara Palumbo, Celeste Manfredi, Riccardo Autorino
BACKGROUND: Upper tract urothelial carcinoma (UTUC) is a rare disease with a potentially dismal prognosis. We systematically compared international guidelines on UTUC to analyze similitudes and differences among them. METHODS: We conducted a search on MEDLINE/PubMed for guidelines related to UTUC from 2010 to the present. In addition, we manually explored the websites of urological and oncological societies and journals to identify pertinent guidelines. We also assessed recommendations from the International Bladder Cancer Network, the Canadian Urological Association, the European Society for Medical Oncology, and the International Consultation on Bladder Cancer, considering their expertise and experience in the field...
March 11, 2024: Cancers
https://read.qxmd.com/read/38538270/antibacterial-properties-of-bacterial-endophytes-isolated-from-the-medicinal-plant-origanum-heracleoticum-l
#24
JOURNAL ARTICLE
Giulia Semenzato, Alberto Bernacchi, Sara Amata, Angela Bechini, Fabiola Berti, Carmela Calonico, Valentina Catania, Antonia Esposito, Anna Maria Puglia, Antonio Palumbo Piccionello, Giovanni Emiliani, Sauro Biffi, Renato Fani
BACKGROUND: Bacterial endophytic communities associated with medicinal plants synthesize a plethora of bioactive compounds with biological activities. Their easy isolation and growth procedures make bacterial endophytes an untapped source of novel drugs, which might help to face the problem of antimicrobial resistance. This study investigates the antagonistic potential of endophytic bacteria isolated from different compartments of the medicinal plant O. heracleoticum against human opportunistic pathogens...
March 19, 2024: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/38535860/ultrasound-and-elastosonographic-features-of-the-patellar-ligament-in-dogs-affected-by-cranial-cruciate-ligament-disease
#25
JOURNAL ARTICLE
Luca Pennasilico, Antonella Volta, Sara Sassaroli, Caterina Di Bella, Valentina Riccio, Nicola Pilati, Adolfo Maria Tambella, Fabrizio Dini, Angela Palumbo Piccionello
This study aims to evaluate the morpho-functional change in the patellar ligament in dogs with cranial cruciate ligament disease. We hypothesized that it may show increased thickening and stiffness with increasing days from onset to diagnosis instead of trauma. Understanding this aspect has implications for the choice of timing for treating patients suffering from cranial cruciate ligament disease, as well as the contextualization of patellar ligament desmitis pictures after surgical treatment with tibial plateau leveling osteotomy or tibial tuberosity advancement...
March 12, 2024: Veterinary Sciences
https://read.qxmd.com/read/38533714/short-term-healthcare-resource-utilization-associated-with-receipt-of-cdc-informed-opioid-thresholds-among-commercially-insured-new-chronic-opioid-users
#26
JOURNAL ARTICLE
Martin J Calabrese, Fadia T Shaya, Francis Palumbo, Mary Lynn McPherson, Ester Villalonga-Olives, Zafar Zafari, Ryan Mutter
OBJECTIVE: To evaluate the impact of recent changes to the Centers for Disease Control and Prevention (CDC) morphine milligram equivalent (MME)/day threshold recommendations on healthcare utilization. DESIGN: A retrospective cohort study of new chronic opioid users (NCOUs). SETTING: Commercially insured plans across the United States using IQVIA PharMetrics® Plus for Academics database with new use between January 2014 and March 2015...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38528177/aso-visual-abstract-very-early-recurrence-after-curative-resection-for-pancreatic-ductal-adenocarcinoma-proof-of-concept-for-a-biologic-r2-definition
#27
JOURNAL ARTICLE
Giulio Belfiori, Stefano Crippa, Michele Pagnanelli, Giulia Gasparini, Francesca Aleotti, Paolo Riccardo Camisa, Stefano Partelli, Nicolò Pecorelli, Federico De Stefano, Marco Schiavo Lena, Diego Palumbo, Domenico Tamburrino, Michele Reni, Massimo Falconi
No abstract text is available yet for this article.
March 25, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38525036/antibacterial-activity-of-arthrobacter-strains-isolated-from-great-gobi-a-strictly-protected-area-mongolia
#28
JOURNAL ARTICLE
Alberto Bernacchi, Giulia Semenzato, Manuel di Mascolo, Sara Amata, Angela Bechini, Fabiola Berti, Carmela Calonico, Valentina Catania, Giovanni Emiliani, Antonia Esposito, Claudia Greco, Stefano Mocali, Nadia Mucci, Anna Padula, Antonio Palumbo Piccionello, Battogtokh Nasanbat, Gantulga Davaakhuu, Munkhtsetseg Bazarragchaa, Francesco Riga, Claudio Augugliaro, Anna Maria Puglia, Marco Zaccaroni, Fani Renato
Desert soil hosts many microorganisms, whose activities are essential from an ecological viewpoint. Moreover, they are of great anthropic interest. The knowledge of extreme environments microbiomes may be beneficial for agriculture, technology, and human health. In this study, 11 Arthrobacter strains from topsoil samples collected from the Great Gobi A Strictly Protected Area in the Gobi Desert, were characterized by a combination of different techniques. The phylogenetic analysis, performed using their 16S rDNA sequences and the most similar Arthrobacter sequences found in databases, revealed that most of them were close to A...
2024: AIMS Microbiology
https://read.qxmd.com/read/38523582/post-diagnosis-serum-25-hydroxyvitamin-d-concentrations-in-women-treated-for-breast-cancer-participating-in-a-lifestyle-trial-in-italy
#29
JOURNAL ARTICLE
A Fassio, G Porciello, G Carioli, E Palumbo, S Vitale, A Luongo, C Montagnese, M Prete, M Grimaldi, R Pica, E Rotondo, L Falzone, I Calabrese, A Minopoli, B Grilli, M Cuomo, P C Fiorillo, C Evangelista, E Cavalcanti, M De Laurentiis, D Cianniello, C Pacilio, M Pinto, G Thomas, M Rinaldo, M D'Aiuto, D Serraino, S Massarut, A Steffan, F Ferraù, R Rossello, F Messina, F Catalano, G Adami, F Bertoldo, M Libra, A Crispo, E Celentano, C La Vecchia, L S A Augustin, D Gatti
OBJECTIVE: To report cross-sectionally serum levels of 25-hydroxyvitamin D [25(OH)D] in women living in Italy within 12 months from breast cancer (BC) diagnosis. METHODS: Baseline data were obtained from 394 women diagnosed with primary BC, enrolled from 2016 to 2019 in a lifestyle trial conducted in Italy. Subjects' characteristics were compared between two 25(OH)D concentrations (hypovitaminosis D<20 and ≥20 ng/mL) with the Chi-squared test or Fisher's exact test for small-expected counts...
March 22, 2024: Reumatismo
https://read.qxmd.com/read/38510313/real-practice-management-and-treatment-of-idiopathic-multicentric-castleman-disease-with-siltuximab-a-collection-of-clinical-experiences
#30
JOURNAL ARTICLE
Bernardo Rossini, Nicola Cecchi, Felice Clemente, Maria Rosaria De Paolis, Stefan Hohaus, Vanessa Innao, Mariano Lucignano, Roberto Massaiu, Giovanna Palumbo, Gian Matteo Rigolin, Francesca Gaia Rossi, Luisa Verga, Attilio Guarini
Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant...
2024: Drugs in Context
https://read.qxmd.com/read/38507052/deficits-in-emotion-recognition-and-processing-in-children-with-high-callous-unemotional-traits-the-role-of-the-maoa-gene
#31
JOURNAL ARTICLE
Pietro Muratori, Sara Palumbo, Stefano Vellucci, Veronica Mariotti, Lucia Billeci, Valentina Levantini, Emanuela Inguaggiato, Gabriele Masi, Annarita Milone, Silvia Pellegrini
Children with high Callous-Unemotional (CU) traits show deficits in recognizing and processing facial expressions. Alterations in emotion recognition have been linked to a higher synaptic concentration of monoaminergic neurotransmitters. The current study investigated the relationship between the MAOA-Low-activity alleles and the ability to recognize and process facial expressions in 97 male children (8-12 years old) diagnosed with disruptive behavior disorder. Participants completed a computerized emotion-recognition task while an eye-tracking system recorded the number (Fixation Count, FC) and length (Fixation Duration, FD) of fixations to the eye region of the emotional stimuli...
March 20, 2024: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/38503658/diagnosis-and-management-of-anemia-in-pediatric-inflammatory-bowel-diseases-clinical-practice-guidelines-on-behalf-of-the-sigenp-ibd-working-group
#32
Massimo Martinelli, Maria Teresa Fioretti, Marina Aloi, Patrizia Alvisi, Serena Arrigo, Claudia Banzato, Matteo Bramuzzo, Angelo Campanozzi, Fortunata Civitelli, Daniela Knafelz, Paolo Lionetti, Antonio Marseglia, Francesca Musto, Lorenzo Norsa, Giuseppe Palumbo, Sara Renzo, Claudio Romano, Naire Sansotta, Caterina Strisciuglio, Erasmo Miele
Anemia is one of the most frequent extra-intestinal manifestations of inflammatory bowel disease. Insidious onset, variability of symptoms and lack of standardized screening practices may increase the risk of underestimating its burden in children with IBD. Despite its relevance and peculiarity in everyday clinical practice, this topic is only dealt with in a few documents specifically for the pediatric field. The aim of the current guidelines is therefore to provide pediatric gastroenterologists with a practical update to support the clinical and therapeutic management of children with IBD and anemia...
March 18, 2024: Digestive and Liver Disease
https://read.qxmd.com/read/38502041/reduced-fertilization-to-improve-sustainable-use-of-resources-and-preserve-postharvest-quality-of-fresh-cut-wild-rocket-diplotaxis-tenuifolia-l-in-soil-bound-and-soilless-cultivation
#33
JOURNAL ARTICLE
Michela Palumbo, Lucia Bonelli, Bernardo Pace, Francesco Fabiano Montesano, Francesco Serio, Maria Cefola
Reducing fertilizer input is a goal for helping greenhouse farming to achieve higher sustainability in the production process while preserving overall crop performance and quality. Wild rocket plants were cultivated in a plastic greenhouse divided into two independent sectors, one for soil-bound (SbS) cultivation and another equipped for soilless (ScS) cultivation systems. In both SbS and ScS, the crop was subjected to treatments consisting of a high- and a low-input fertilization program (HF and LF treatment, respectively)...
February 10, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38499844/detecting-implicit-and-explicit-facial-emotions-at-different-ages
#34
JOURNAL ARTICLE
Giulia Prete, Irene Ceccato, Emanuela Bartolini, Adolfo Di Crosta, Pasquale La Malva, Rocco Palumbo, Bruno Laeng, Luca Tommasi, Nicola Mammarella, Alberto Di Domenico
Emotions are processed in the brain through a cortical route, responsible for detailed-conscious recognition and mainly based on image High Spatial Frequencies (HSF), and a subcortical route, responsible for coarse-unconscious processing and based on Low SF (LSF). However, little is known about possible changes in the functioning of the two routes in ageing. In the present go/no-go online task, 112 younger adults and 111 older adults were asked to press a button when a happy or angry face appeared (go) and to inhibit responses for neutral faces (no-go)...
March 19, 2024: European Journal of Ageing
https://read.qxmd.com/read/38484210/investigation-of-serum-albumin-as-a-dynamic-treatment-specific-surrogate-for-outcomes-in-patients-with-myelofibrosis-treated-with-ruxolitinib
#35
JOURNAL ARTICLE
Andrew T Kuykendall, Somedeb Ball, Barbara Mora, Qianxing Mo, Najla Al Ali, Margherita Maffioli, Giuseppi Auteri, Camilla Mazzoni, Giuseppe A Palumbo, Andrea Duminuco, Anna Longo, Elena M Elli, Francesco Passamonti, Francesca Palandri, Rami Komrokji
PURPOSE: Ruxolitinib improves splenomegaly and disease-related symptoms in most patients with myelofibrosis (MF), and it has been associated with a survival benefit in higher-risk patients with splenomegaly. Spleen volume reduction has been associated with a survival benefit in ruxolitinib-treated patients; however, its use as a surrogate is limited. We hypothesized that an anti-inflammatory response to ruxolitinib would correlate with improved patient outcomes. METHODS: We interrogated serum albumin, an acute phase reactant and marker of nutritional status in 590 patients with MF and analyzed differential trajectories of albumin on the basis of ruxolitinib treatment...
March 2024: JCO Precision Oncology
https://read.qxmd.com/read/38484067/the-dtc-microbiome-testing-industry-needs-more-regulation
#36
JOURNAL ARTICLE
Diane E Hoffmann, Erik C von Rosenvinge, Mary-Claire Roghmann, Francis B Palumbo, Daniel McDonald, Jacques Ravel
Tests lack analytical and clinical validity, requiring more federal oversight to prevent consumer harm.
March 15, 2024: Science
https://read.qxmd.com/read/38483962/guanfacine-for-the-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-with-down-syndrome-a-retrospective-chart-review
#37
JOURNAL ARTICLE
James H Powers, Michael Wu, Michelle Palumbo, Christopher J Keary, Christopher J McDougle, Caitlin Ravichandran, Robyn P Thom
Study Design: Retrospective case series. Objectives: The objective of this study was to provide naturalistic data on the use of guanfacine for the treatment of attention-deficit/hyperactivity disorder (ADHD) in a clinically referred sample of youth with Down syndrome (DS). Methods: The medical records of children and adolescents with DS who received guanfacine for the treatment of ADHD from a multidisciplinary neurodevelopmental disorder clinic between September 1, 2011, and September 10, 2021, were reviewed...
March 2024: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/38483814/unmasking-the-impact-of-oxygenator-induced-hypocapnia-on-blood-lactate-in-veno-arterial-extracorporeal-membrane-oxygenation
#38
JOURNAL ARTICLE
Mousa Kharnaf, William A Abplanalp, Courtney Young, Cassandra Sprague, Leah Rosenfeldt, Reanna Smith, Dongfang Wang, Joseph S Palumbo, David L S Morales
Extracorporeal membrane oxygenation (ECMO) is often associated with disturbances in acid/base status that can be triggered by the underlying pathology or the ECMO circuit itself. Extracorporeal membrane oxygenation is known to cause hypocapnia, but the impact of reduced partial pressure of carbon dioxide (pCO2) on biomarkers of tissue perfusion during veno-arterial (VA)-ECMO has not been evaluated. To study the impact of low pCO2 on perfusion indices in VA-ECMO, we placed Sprague-Dawley rats on an established VA-ECMO circuit using either an oxygen/carbon dioxide mixture (O2 95%, CO2 5%) or 100% O2 delivered through the oxygenator (n = 5 per cohort)...
March 14, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38478023/ruxolitinib-adherence-in-myelofibrosis-and-polycythemia-vera-the-ramp-italian-multicenter-prospective-study
#39
JOURNAL ARTICLE
F Palandri, G Auteri, E Abruzzese, G Caocci, M Bonifacio, F Mendicino, R Latagliata, A Iurlo, F Branzanti, B Garibaldi, M M Trawinska, D Cattaneo, M Krampera, O Mulas, E A Martino, M Cavo, N Vianelli, S Impera, F Efficace, F Heidel, M Breccia, E M Elli, G A Palumbo
Ruxolitinib is beneficial in patients with myelofibrosis (MF) and polycythemia vera (PV). Information on ruxolitinib adherence is scant. The Ruxolitinib Adherence in Myelofibrosis and Polycythemia Vera (RAMP) prospective multicenter study (NCT06078319) included 189 ruxolitinib-treated patients. Patients completed the Adherence to Refills and Medications Scale (ARMS) and Distress Thermometer and Problem List (DTPL) at the earliest convenience, after registration in the study, and at later timepoints. At week-0, low adherence (ARMS > 14) and high distress (DT ≥ 4) were declared by 49...
March 13, 2024: Annals of Hematology
https://read.qxmd.com/read/38473069/transversus-abdominis-plane-tap-block-in-rabbit-cadavers-anatomical-description-and-measurements-of-injectate-spread-using-one-and-two-point-approaches
#40
JOURNAL ARTICLE
Federica Serino, Luca Pennasilico, Margherita Galosi, Angela Palumbo Piccionello, Adolfo Maria Tambella, Caterina Di Bella
The aim of this study was to describe one-point (preiliac approach) and two-point (preiliac and retrocostal approach) blocks of the Transversus Abdominis Plane (TAP) on a cadaveric model. For this purpose, ultrasound-guided infiltration of the plane between the internal oblique and transversus abdominis muscles was performed and, after dissection of tissues, the areas and percentage of nerve fibers involved were analyzed. Injection into the TAP plexus of a 1 mL/kg solution of 2% lidocaine and 1% methylene blue (1:1) was performed in 30 rabbit cadavers...
February 22, 2024: Animals: An Open Access Journal From MDPI
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