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https://www.readbyqxmd.com/read/29157566/is-health-care-payment-reform-impacting-nurses-work-settings-roles-and-education-preparation
#1
Mary Val Palumbo, Betty Rambur, Vicki Hart
This study explores nurses' work settings and educational preparation in the five years before passage of the Affordable Care Act (ACA) and five years after ACA passage, with the aim of identifying areas for nurse educators' attention. The study setting was one small state undergoing rapid transition away from fee-for-service service and thus provided the ideal laboratory to assess the impact of health reform on the nursing workforce. A secondary analysis of data gathered during relicensure compared the nursing workforce at an interval of one decade, with surveys in 2005 (n=4075; 65% response rate) and in 2015 (n=6723; 97% response rate)...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29156220/the-epilepsy-phenotype-in-adult-patients-with-intellectual-disability-and-pathogenic-copy-number-variants
#2
Giuseppe d'Orsi, Tommaso Martino, Orazio Palumbo, Maria Grazia Pascarella, Pietro Palumbo, Maria Teresa Di Claudio, Carlo Avolio, Massimo Carella
PURPOSE: To characterize the electroclinical features of epilepsy associated with intellectual disability and pathogenic copy number variations (CNVs) METHODS: we prospectively investigated 61 adult patients with epilepsy and intellectual disability or other neurodevelopmental disorders. We performed high resolution SNP-Array analysis in order to detect clinical relevant chromosomal microdeletions and microduplications. An ordinal logistic regression model was fitted with 34 demographic, clinical and EEG-related variables in order to identify the epilepsy phenotype of patients with pathogenic CNVs...
November 14, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29150503/carbon-amendments-alter-microbial-community-structure-and-net-mercury-methylation-potential-in-sediments
#3
Geoff A Christensen, Anil C Somenahally, James G Moberly, Carrie M Miller, Andrew J King, Cynthia C Gilmour, Steven D Brown, Mircea Podar, Craig C Brandt, Scott C Brooks, Anthony V Palumbo, Judy D Wall, Dwayne A Elias
Neurotoxic methylmercury (MeHg) is produced by anaerobic Bacteria and Archaea possessing the genes hgcAB, but it is unknown how organic substrate and electron acceptor availability impact the distribution and abundance of these organisms. We evaluated the impact of organic substrate amendments on mercury (Hg) methylation rates, microbial community structure, and the distribution of hgcAB(+) microbes with sediments. Sediment slurries were amended with short-chain fatty acids, alcohols, or a polysaccharide. Minimal increases in MeHg were observed following lactate, ethanol and methanol amendments while a significant decrease (∼70%) was observed with cellobiose incubations...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29148013/vitom%C3%A2-3d-system-in-surgeon-microsurgical-vascular-training-our-model-and-experience
#4
Vincenzo Davide Palumbo, Salvatore Fazzotta, Giuseppe Damiano, Attilio Ignazio Lo Monte
No abstract text is available yet for this article.
November 11, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29144603/hyaluronic-acid-based-micelles-as-ocular-platform-to-modulate-the-loading-release-and-corneal-permeation-of-corticosteroids
#5
Flavia Bongiovì, Giulia Di Prima, Fabio S Palumbo, Mariano Licciardi, Giovanna Pitarresi, Gaetano Giammona
The aim of this work is to prepare hyaluronic acid-based micelles as a platform to load corticosteroid drugs and to improve their corneal permeation after administration on the ocular surface. Three amphiphilic derivatives of hyaluronic acid (HA) are synthesized using different amounts of hexadecylamine (C16 -NH2 ). HAC16 a, HAC16 b, and HAC16 c derivatives are able to form micelles by the cosolvent evaporation method and to entrap corticosteroids (dexamethasone, triamcinolone, triamcinolone acetonide). HAC16 a and HAC16 b micelles show the best results in terms of drug loading and particle size...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29133219/dietary-fatty-acid-modification-for-the-treatment-of-aspirin-exacerbated-respiratory-disease-a-prospective-pilot-trial
#6
Thomas R Schneider, Christina B Johns, Marina L Palumbo, Katherine C Murphy, Katherine N Cahill, Tanya M Laidlaw
BACKGROUND: The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control. OBJECTIVE: To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD. METHODS: Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women's Hospital in Boston, MA...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29128150/structural-and-ultrastructural-analyses-of-bone-regeneration-in-rabbit-cranial-osteotomy-piezosurgery-versus-traditional-osteotomes
#7
Alexandre Anesi, Marzia Ferretti, Francesco Cavani, Roberta Salvatori, Michele Bianchi, Alessandro Russo, Luigi Chiarini, Carla Palumbo
Clinical advantages of piezosurgery have been already proved. However, few investigations have focused on the dynamics of bone healing. The aim of this study was to evaluate, in adult rabbits, bone regeneration after cranial linear osteotomies with two piezoelectrical devices (Piezosurgery(®) Medical - PM and Piezosurgery(®) Plus - PP), comparing them with conventional rotary osteotomes (RO). PP was characterized by an output power three times higher than PM. Fifteen days after surgery, histomorphometric analyses showed that the osteotomy gap produced with PM and PP was about half the size of that produced by RO, and in a more advanced stage of recovery...
October 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29127781/editorial-comment
#8
Alessandro Antonelli, Carlotta Palumbo
No abstract text is available yet for this article.
November 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29121206/effects-of-temperatures-on-immature-development-and-survival-of-the-invasive-stink-bug-hemiptera-pentatomidae
#9
Darcy A Reed, Fatemeh Ganjisaffar, John C Palumbo, Thomas M Perring
Bagrada hilaris (Burmeister) (Hemiptera: Pentatomidae) is a non-native stink bug that feeds primarily on cole crops and wild mustards. Its invasion into desert agriculture in California and Arizona presents a conundrum between rapid pest development at warm temperatures and severe damage to cool season crops. In this study, the development and survival of B. hilaris were determined at nine constant temperatures (ranging from 20-42°C) when reared on organically grown broccoli florets. Egg hatching was greatly delayed at 20°C, and first instar nymphs did not survive at this temperature...
November 7, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29120401/does-locoregional-chemotherapy-still-matter-in-the-treatment-of-advanced-pelvic-melanoma
#10
Stefano Guadagni, Giammaria Fiorentini, Marco Clementi, Giancarlo Palumbo, Paola Palumbo, Alessandro Chiominto, Stefano Baldoni, Francesco Masedu, Marco Valenti, Ambra Di Tommaso, Bianca Fabi, Camillo Aliberti, Donatella Sarti, Veronica Guadagni, Cristina Pellegrini
Pelvic Melanoma relapse occurs in 15% of patients with loco regional metastases, and 25% of cases do not respond to new target-therapy and/or immunotherapy. Melphalan hypoxic pelvic perfusion may, therefore, be an option for these non-responsive patients. Overall median survival time (MST), stratified for variables, including BRAF V600E mutation and eligibility for treatments with new immunotherapy drugs, was retrospectively assessed in 41 patients with pelvic melanoma loco regional metastases. They had received a total of 175 treatments with Melphalan hypoxic perfusion and cytoreductive excision...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29112434/n-butyl-l-deoxynojirimycin-l-nbdnj-synthesis-of-an-allosteric-enhancer-of-%C3%AE-glucosidase-activity-for-the-treatment-of-pompe-disease
#11
Daniele D'Alonzo, Maria De Fenza, Caterina Porto, Roberta Iacono, Mylene Huebecker, Beatrice Cobucci-Ponzano, David Priestman, Frances M Platt, Giancarlo Parenti, Marco Moracci, Giovanni Palumbo, Annalisa Guaragna
The highly stereocontrolled de novo synthesis of L-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preliminary evaluation of its chaperoning potential are herein reported. L-NBDNJ is able to enhance lysosomal α-glucosidase levels in Pompe disease fibroblasts, either when administered singularly or when co-incubated with the recombinant human α-glucosidase. In addition, differently from its D-enantiomer, L-NBDNJ does not act as a glycosidase inhibitor.
November 7, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29112069/neuropsychological-performance-in-african-children-with-hiv-enrolled-in-a-multi-site-anti-retroviral-clinical-trial
#12
Michael J Boivin, Linda Barlow-Mosha, Miriam Chernoff, Barbara Laughton, Bonnie Zimmer, Celeste Joyce, Mutsa Bwakura-Dangarembizi, Mmule Ratswana, Nasreen Abrahams, Lee Fairlie, Hermien Gous, Portia Kamthunzi, Katie McCarthy, Itziar Familiar-Lopez, Patrick Jean-Phillippe, Joan Coetzee, Avy Violari, Mark Cotton, Paul Palumbo
OBJECTIVE & DESIGN: Children with HIV infection (HIV+) are at neuropsychological risk, but few studies have evaluated this at multiple sites in low and middle income countries (LMICs). We compared neuropsychological outcomes at enrollment (>5 yrs age) among HIV+, HIV-uninfected perinatally-exposed (HEU), and HIV unexposed (HU) children from 4 sub-Saharan countries. METHODS: IMPAACT P1060 compared Nevirapine (NVP) versus Lopinavir/Ritonavir (LPVr)-based ART in HIV-infected children 6 to 35 months of age...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29108454/pten-physically-interacts-with-and-regulates-e2f1-mediated-transcription-in-lung-cancer
#13
Prerna Malaney, Emily Palumbo, Jonathan Semidey-Hurtado, Jamaal Hardee, Katherine Stanford, Jaymin J Kathiriya, Deepal Patel, Zhi Tian, Diane Allen-Gipson, Vrushank Davé
PTEN phosphorylation at its C-terminal (C-tail) serine/threonine cluster negatively regulates its tumor suppressor function. However, the consequence of such inhibition and its downstream effects in driving lung cancer remain unexplored. Herein, we ascertain the molecular mechanisms by which phosphorylation compromises PTEN function, contributing to lung cancer. Replacement of the serine/threonine residues with alanine generated PTEN-4A, a phosphorylation-deficient PTEN mutant, which suppressed lung cancer cell proliferation and migration...
November 6, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29108288/baseline-factors-associated-with-response-to-ruxolitinib-an-independent-study-on-408-patients-with-myelofibrosis
#14
Francesca Palandri, Giuseppe Alberto Palumbo, Massimiliano Bonifacio, Mario Tiribelli, Giulia Benevolo, Bruno Martino, Elisabetta Abruzzese, Mariella D'Adda, Nicola Polverelli, Micaela Bergamaschi, Alessia Tieghi, Francesco Cavazzini, Adalberto Ibatici, Monica Crugnola, Costanza Bosi, Roberto Latagliata, Ambra Di Veroli, Luigi Scaffidi, Federico de Marchi, Elisa Cerqui, Barbara Anaclerico, Giovanna De Matteis, Marco Spinsanti, Elena Sabattini, Lucia Catani, Franco Aversa, Francesco Di Raimondo, Umberto Vitolo, Roberto Massimo Lemoli, Renato Fanin, Francesco Merli, Domenico Russo, Antonio Cuneo, Maria Letizia Bacchi Reggiani, Michele Cavo, Nicola Vianelli, Massimo Breccia
In patients with Myelofibrosis (MF) treated with ruxolitinib (RUX), the response is unpredictable at therapy start. We retrospectively evaluated the impact of clinical/laboratory factors on responses in 408 patients treated with RUX according to prescribing obligations in 18 Italian Hematology Centers. At 6 months, 114 out of 327 (34.9%) evaluable patients achieved a spleen response. By multivariable Cox proportional hazard regression model, pre-treatment factors negatively correlating with spleen response were: high/intermediate-2 IPSS risk (p=0...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105701/-engagement-as-motivational-driver-processes-of-change-in-an-italian-department-of-mental-health
#15
Carmine Fuschillo, Catello Orazzo, Gabriele Gennaro Orazzo, Elena Capriola, Rocco Palumbo, Manlio Grimaldi
The health care reforms of last years have deeply affected the National Health System, resulting in the need for a change in organizational processes and a more efficient and dynamic change management. An effective change management is not possible without a deep involvement (engagement) of professionals, which is itself a key requisite for motivation. This study aims to examine the main instruments of engagement management, as a tool of change according to a modern reorganization approach. We examine the results of this process in the Mental Health Department of the Local Health Company Naples 3 South in recent years, starting with the analysis of its main weaknesses...
September 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29097378/men1-gene-mutation-with-parathyroid-carcinoma-first-report-of-a-familial-case
#16
Luigia Cinque, Angelo Sparaneo, Antonio S Salcuni, Danilo de Martino, Claudia Battista, Francesco Logoluso, Orazio Palumbo, Roberto Cocchi, Evaristo Maiello, Paolo Graziano, Geoffrey N Hendy, David E C Cole, Alfredo Scillitani, Vito Guarnieri
BACKGROUND: The occurrence of parathyroid carcinoma in multiple endocrine neoplasia type I (MENI) is rare and the 15 cases of malignant parathyroid tumor reported so far have been associated with MENI in individuals and not with multiple members within a family. METHODS: We report on a 61-year-old male, operated for a 7.3 cm parathyroid carcinoma infiltrating the esophagus. In his brother, a 4.6 cm parathyroid carcinoma was diagnosed histologically, while in the daughter, neck ultrasonography revealed 2 extrathyroidal nodules, yet to be excised...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29094769/differentiation-and-characterization-of-rat-adipose-tissue-mesenchymal-stem-cells-into-endothelial-like-cells
#17
V Cannella, G Piccione, R Altomare, A Marino, P Di Marco, L Russotto, S Di Bella, G Purpari, F Gucciardi, G Cassata, G Damiano, V D Palumbo, A Santoro, C Russo Lacerna, A I Lo Monte, A Guercio
In this study, mesenchymal stem cells were isolated from rat adipose tissue (AD-MSCs) to characterize and differentiate them into endothelial-like cells. AD-MSCs were isolated by mechanical and enzymatic treatments, and their identity was verified by colony-forming units (CFU) test and by differentiation into cells of mesodermal lineages. The endothelial differentiation was induced by plating another aliquot of cells in EGM-2 medium, enriched with specific endothelial growth factors. Five subcultures were performed...
November 2, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29090385/phase-ii-open-label-pilot-trial-of-aprepitant-and-palonosetron-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-cinv-in-patients-receiving-moderately-emetogenic-folfox-chemotherapy-for-the-treatment-of-colorectal-cancer
#18
Joseph S Bubalo, Jon D Herrington, Marc Takemoto, Patricia Willman, Michael S Edwards, Casey Williams, Alan Fisher, Alison Palumbo, Eric Chen, Charles Blanke, Charles D Lopez
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) causes significant morbidity among colorectal cancer patients, receiving fluorouracil, oxaliplatin, and leucovorin (FOLFOX) chemotherapy even with standard antiemetic prophylaxis. The purpose of this study is to determine if the addition of aprepitant to standard antiemetic therapy improves CINV in these patients. METHODS: Patients receiving FOLFOX for colorectal cancer were given antiemetic prophylaxis with aprepitant 125 mg orally on day 1 and 80 mg on days 2 and 3...
October 31, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29083339/reoperation-for-persistent-or-recurrent-secondary-hyperparathyroidism
#19
Alida Abruzzo, Maria Concetta Gioviale, Giuseppe Damiano, Vincenzo Davide Palumbo, Salvatore Buscemi, Giulia Lo Monte, Leonardo Gulotta, Giuseppe Buscemi, Attilio Ignazio Lo Monte
BACKGROUND: Secondary hyperparathyroidism is a common acquired disorder seen in chronic renal failure. Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. When medical treatment fails, subtotal and total parathyroidectomy with autotransplantation are the standard procedures, although both are associated with high recurrence rates. METHODS AND RESULTS: 4 patients experienced persistence and 9 relapse. The first 4 were subjected to reoperation after 6 months for the persistence of symptoms due to the finding of a supernumerary adenomatous gland while the remaining patients at the reoperation showed in 5 cases 2 more glands in over thymic position, and 4 an hyperplasia of the residual glandular tissue...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29081189/-clinical-features-and-prognosis-of-93-elderly-patients-with-multiple-myeloma
#20
H M Chen, F Zhou, W Wei, R Peng, H T Shi, J Hou
Objective: To explore the clinical features and prognostic factors of elderly MM patients. Methods: A retrospectively analysis of clinical characteristics in 93 newly diagnosed MM patients with more than 70 years of old between August 2011 and August 2016. Based on age, basic activities of daily living scale, instrumental activities of daily living scale, Charlson comorbidity index at diagnosis, patients were divided into three groups: Fit (score=0, n=15) , Intermediate fitness (score=1, n=31) , Frail (score≥2, n=47) according to a geriatric assessment system proposed by Antonio Palumbo et al...
September 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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