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Katherine Wittling, Jessica Palumbo Dufur, Ashley McClain, Margaret Gettis
BACKGROUND: Surgical encounters for children with Autism Spectrum Disorder (ASD) are stressful to patients, families and health care providers. It is recognized that parents best anticipate needs of children with ASD. Including a family in the plan of care for the child is imperative. In response to the need for targeted, tailored care, an inter-professional surgical services team convened to determine best practices for addressing a behavioral and developmental plan for children with ASD in the surgical services arena...
May 17, 2018: Journal of Pediatric Nursing
Ferdinando Antonio Gulino, F Di Guardo, E Zambrotta, L M Di Gregorio, Andrea Miranda, Stella Capriglione, M A Palumbo
PURPOSE: We studied the efficacy of using pre-cesarean delivery (CD) temporary occlusion of internal iliac arteries with balloon catheters in case of placenta previa-accreta in terms of maternal and neonatal outcomes and to test accuracy of ultrasound (US) and magnetic resonance imaging (MRI) for prenatal diagnosis. METHODS: From March 2014 to January 2018, women with an US and/or MRI diagnosis of placenta previa-accreta and a planned delivery were enrolled and divided into two groups: balloon catheterization group (women treated with preoperative catheters and CD) and control group (women candidates to elective CD)...
May 18, 2018: Archives of Gynecology and Obstetrics
Angelo Caputo, Marco De Santis, Valerio Manno, Gabriella Cauzillo, Biagio Maria Bruni, Lorenzo Palumbo, Susanna Conti, Pietro Comba
OBJECTIVES: to estimate the health impact of asbestos fibres naturally occurring in Mount Pollino area (Basilicata Region, Southern Italy). DESIGN: geographic mortality, hospitalization, and incidence study. Setting and participant s: population resident in 12 Municipalities of Mount Pollino area with naturally occurring asbestos fibres. MAIN OUTCOME MEASURES: standardized mortality ratio (SMR) and standardized hospitalization rate (SHR) for asbestos-related diseases; standardized incidence ratio (SIR) for mesotheliomas...
March 2018: Epidemiologia e Prevenzione
Paola Sena, Stefano Mancini, Marta Benincasa, Francesco Mariani, Carla Palumbo, Luca Roncucci
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anti-cancer properties. Metformin reduced the incidence and growth of experimental tumors in vivo. In a randomized clinical trial among nondiabetic patients, metformin treatment significantly decreased the number of aberrant crypt foci compared to the untreated group with a follow-up of 1 month. In our study, HT29 cells were treated with graded concentrations of metformin, 10 mM/25 mM/50 mM for 24/48 h. We performed immunofluorescence experiments by means of confocal microscopy and western blot analysis to evaluate a panel of factors involved in apoptotic/autophagic processes and oxidative stress response...
May 16, 2018: International Journal of Molecular Sciences
Michele Teodoro, Maurizio Mannino, Marco Vitale, Edoardo Mattone, Valentina Palumbo, Filippo Fraggetta, Adriana Toro, Isidoro Di Carlo
BACKGROUND: Inguinal hernia is one of the most common benign pathologies that primarily affects men. Primary gastrointestinal non-Hodgkin's lymphoma (PGI NHL) is the most common type of extranodal lymphoma. This study reports a rare case in which these two conditions co-exist. CASE PRESENTATION: An 85-year-old male complained of bowel movement pattern change, abdominal distension and loss of weight, without vomiting but with nausea. A computed tomographic scan of the abdomen showed a small bowel obstruction caused by a migration of a small bowel loop in the right inguinal canal, with a clinically non-reducible inguinal hernia...
May 15, 2018: World Journal of Surgical Oncology
Lucia Anna Muscarella, Daniela Turchetti, Andrea Fontana, Filomena Baorda, Orazio Palumbo, Annamaria la Torre, Danilo de Martino, Renato Franco, Nunzia Simona Losito, Andrea Repaci, Uberto Pagotto, Luigia Cinque, Massimiliano Copetti, Maria Grazia Chiofalo, Luciano Pezzullo, Paolo Graziano, Alfredo Scillitani, Vito Guarnieri
The Hyperparathyroidism with Jaw-Tumours syndrome is caused by mutations of the CDC73 gene: it has been suggested that early onset of the disease and high Ca2+ levels may predict the presence of a CDC73 mutation. We searched for large deletions at the CDC73 locus in patients with: HPT-JT (nr 2), atypical adenoma (nr 7) or sporadic parathyroid carcinoma (nr 11) with a specific MLPA and qRT-PCR assays applied on DNA extracted from whole blood. A Medline search in database for all the papers reporting a CDC73 gene mutation, clinical/histological diagnosis, age at onset, Ca2+ , PTH levels for familial/sporadic cases was conducted with the aim to possibly identify biochemical/clinical markers predictive, in first diagnosis, of the presence of a CDC73 gene mutation...
April 17, 2018: Oncotarget
Rosita Primavera, Paola Palumbo, Christian Celia, Felisa Cilurzo, Benedetta Cinque, Elisabetta Carata, Maria Carafa, Donatella Paolino, Maria Grazia Cifone, Luisa Di Marzio
No abstract text is available yet for this article.
May 5, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Flavio Esposito, Aldobenedetto Zotti, Giovanna Palumbo, Simona Zuppolini, Marco Consales, Antonello Cutolo, Anna Borriello, Stefania Campopiano, Mauro Zarrelli, Agostino Iadicicco
In this work, we report the in-field demonstration of a liquefied petroleum gas monitoring system based on optical fiber technology. Long-period grating coated with a thin layer of atactic polystyrene (aPS) was employed as a gas sensor, and an array comprising two different fiber Bragg gratings was set for the monitoring of environmental conditions such as temperature and humidity. A custom package was developed for the sensors, ensuring their suitable installation and operation in harsh conditions. The developed system was installed in a real railway location scenario (i...
May 5, 2018: Sensors
Christine D Czoli, Maciej L Goniewicz, Mary Palumbo, Christine M White, David Hammond
BACKGROUND: Although several countries, including Canada, have prohibited the sale of nicotine-containing e-cigarettes, there is little evidence examining the impact of such regulatory measures on nicotine content and labelling. METHODS: E-cigarettes were systematically purchased at 80 retail outlets across 4 cities in Ontario, Canada in January-February 2015. Products' nicotine content and labelling accuracy were assessed using gas chromatography. RESULTS: A total of 166 e-cigarette products were purchased, including disposable products (33%), refillable products (14%), and e-liquids (53%)...
May 4, 2018: International Journal on Drug Policy
Rosa De Finis, Davide Palumbo, Livia Maria Serio, Luigi A C De Filippis, Umberto Galietti
The characterization of the fatigue behaviour of aluminium alloys is still capturing the attention of researchers. As it is well known in literature, for certain alloys, in a specific range of cycles number, the S-N curves do not present any asymptote. So that, problems result in the assessment of the fatigue life. In these conditions, the concept of the fatigue limit has to be replaced by the fatigue strength at a fixed number of loading cycles. Temperature acquisitions during fatigue tests allow for a specific analysis that can support the researchers in understanding the complex processes that are involved in fatigue and their influence on fatigue life, even for aluminium alloys...
May 2, 2018: Materials
Rocco Palumbo, Nicola Mammarella, Alberto Di Domenico, Beth Fairfield
Difficulties in source monitoring (SM) tasks observed in healthy older adults may be linked to associative memory deficits since SM requires individuals to correctly bind and later remember these bound features to discriminate the origin of a memory. Therefore, focusing attention on discriminating factors that may attenuate older adults' difficulties in attributing contextual information to memories is necessary. We investigated the effect of affective information on source monitoring in younger and older adults by manipulating the type of affective information (pictures and music) and assessing the ability to remember spatial and temporal source details for affective pictures encoded while listening to classical music...
April 30, 2018: Aging Clinical and Experimental Research
Ernesto Di Cesare, Lucia Patriarca, Luca Panebianco, Federico Bruno, Pierpaolo Palumbo, Ester Cannizzaro, Alessandra Splendiani, Antonio Barile, Carlo Masciocchi
Cardiovascular disease is still one of the main causes of death and an early identification of coronary artery disease (CAD) remains the primary step in clinical management of patients with cardiovascular risk factor. Coronary computed tomography angiography (CCTA) has shown high sensitivity in CAD detection and could be helpful as screening method. The purpose of this study was to assess the prevalence of coronary artery disease detected by CCTA in asymptomatic patients with an intermediate risk of CAD. MATERIALS AND METHODS: We retrospectively selected 185 asymptomatic patients with an intermediate Framingan Risk Score (mean age was 62...
April 30, 2018: La Radiologia Medica
Alessandra Romano, Nunziatina Laura Parrinello, Piera La Cava, Daniele Tibullo, Cesarina Giallongo, Giuseppina Camiolo, Fabrizio Puglisi, Marina Parisi, Maria Cristina Pirosa, Enrica Martino, Concetta Conticello, Giuseppe Alberto Palumbo, Francesco Di Raimondo
Objectives Despite improvement in overall response due to the introduction of the first-in-class proteasome inhibitor bortezomib (btz), multiple myeloma (MM) is still an incurable disease due to the immune-suppressive bone marrow (BM) environment. Thus, the authors aimed to identify the role of CD11b+ CD15+ CD14- HLA-DR- granulocytic-like myeloid-derived suppressor cells (PMN-MDSC) in MM patients treated up-front with novel agents. Methods In MM cell lines and primary cells derived by patients affected by MGUS and MM we investigated sensitivity to bortezomib and lenalidomide in presence of Arg-1 and PMN-MDSC...
April 30, 2018: Expert Review of Molecular Diagnostics
Ruthanne Palumbo
Incivility in nursing education is an unfortunate phenomenon affecting nursing students in all aspects of their educational experience. Students and their instructors are often ill equipped to deal with academic incivility and their lack of ability to handle such behaviors has proven detrimental to the future of the nursing profession. Nursing instructors need tools to help educate nursing students on how to recognize uncivil behaviors within themselves as well as others and ways to combat it. This research project addressed these aspects of academic incivility and implemented an e-learning module that was developed to educate students on incivility...
July 2018: Nurse Education Today
Allison S Remiker, Joseph S Palumbo
The association of malignancy and thrombophilia is bidirectional, as evidenced by four decades of studies in animal models showing that hemostatic system components support cancer progression. Consistent with this view, clinical studies have suggested that anticoagulants not only limit thromboembolic complications associated with cancer, but also improve survival by impeding cancer progression, and may even prevent the development of cancer. In order to fully capitalize on this association, a detailed understanding of the mechanisms coupling hemostatic factors to cancer pathogenesis is required...
April 2018: Thrombosis Research
Richat Abbas, Ann C Childress, Praneeta Nagraj, Richard Rolke, Sally A Berry, Donna R Palumbo
PURPOSE: Methylphenidate hydrochloride extended-release chewable tablet (MPH ERCT) is approved for treatment of attention deficit hyperactivity disorder in patients aged 6 years and older. This article evaluates the pharmacokinetic parameters and relative bioavailability of MPH ERCT when chewed versus swallowed whole. METHODS: In this open-label, single-dose, 3-period, 3-treatment crossover study, 12 healthy adult volunteers were randomly assigned to treatment sequence...
April 24, 2018: Clinical Therapeutics
Alessandro Isidori, Lorenza Borin, Elena Elli, Roberto Latagliata, Bruno Martino, Giuseppe Palumbo, Federica Pilo, Federica Loscocco, Giuseppe Visani, Paolo Cianciulli
Excess iron can be extremely toxic for the body and may cause organ damage in the absence of iron chelation therapy. Preclinical studies on the role of free iron on bone marrow function have shown that iron toxicity leads to the accumulation of reactive oxygen species, affects the expression of genes coding for proteins that regulate hematopoiesis, and disrupts hematopoiesis. These effects could be partially attenuated by iron-chelation treatment with deferasirox, suggesting iron toxicity may have a negative impact on the hematopoietic microenvironment...
April 13, 2018: Blood Reviews
Maria Concetta Palumbo, Micaela Morettini, Paolo Tieri, Fasma Diele, Massimo Sacchetti, Filippo Castiglione
The beneficial effects of physical activity for the prevention and management of several chronic diseases are widely recognized. Mathematical modeling of the effects of physical exercise in body metabolism and in particular its influence on the control of glucose homeostasis is of primary importance in the development of eHealth monitoring devices for a personalized medicine. Nonetheless, to date only a few mathematical models have been aiming at this specific purpose. We have developed a whole-body computational model of the effects on metabolic homeostasis of a bout of physical exercise...
April 2018: PLoS Computational Biology
Antonio Barile, Francesco Arrigoni, Federico Bruno, Pierpaolo Palumbo, Chiara Floridi, Roberto L Cazzato, Alfonso Reginelli, Marcello Zappia, Luca Brunese, Luigi Zugaro, Carlo Masciocchi
Interventional radiology has experienced an exponential growth in the last years. Nowadays it is possible to treat painful benign lesions or metastases with optimal results in terms of pain management and disease control. Among the benign lesions, osteoid osteoma is the most frequently treated with minimal invasive techniques and the results are excellent. Another lesion, traditionally treated with surgery (osteoblastoma) represent today another field of application. In the oncological field, metastases are, numerically, the most diffuse indications for treatment...
April 25, 2018: Future Oncology
Gian Enrico Magi, Francesca Mariotti, Sara Berardi, Andrea Piccinini, Cecilia Vullo, Angela Palumbo Piccionello, Giacomo Rossi
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome in veterinary medicine characterized by severe intestinal dysmotility without evidence of mechanical occlusion of the intestinal lumen. The exact pathogenesis of CIPO is unknown. CASE PRESENTATION: A 1-year-old male Miniature Bull Terrier dog was presented with a history of chronic weight loss, regurgitation, lethargy, vomiting and diarrhea. The dog was submitted for exploratory laparotomy...
April 24, 2018: Acta Veterinaria Scandinavica
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