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https://www.readbyqxmd.com/read/29333589/new-species-and-new-record-of-the-genus-cheloniodiplostomum-trematoda-proterodiplostomidae-polycotylinae-parasites-of-freshwater-turtles-from-argentina
#1
Ezequiel Palumbo, Julia Inés Diaz
The aim of the present paper is to describe a new species of the genus Cheloniodiplostomum (Digenea, Proterodiplostomidae) in the Hilaire's toadhead turtle Phrynops hilarii from Argentina and to expand the geographic and host distribution of Cheloniodiplostomum testudinis. Additionally, we present a diagnostic key for Cheloniodiplostomum.
January 15, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29324935/right-putamen-and-age-are-the-most-discriminant-features-to-diagnose-parkinson-s-disease-by-using-123i-fp-cit-brain-spet-data-by-using-an-artificial-neural-network-classifier-a-classification-tree-clt
#2
S Cascianelli, C Tranfaglia, M L Fravolini, F Bianconi, M Minestrini, S Nuvoli, N Tambasco, M E Dottorini, B Palumbo
OBJECTIVE: The differential diagnosis of Parkinson's disease (PD) and other conditions, such as essential tremor and drug-induced parkinsonian syndrome or normal aging brain, represents a diagnostic challenge. 123I-FP-CIT brain SPET is able to contribute to the differential diagnosis. Semiquantitative analysis of radiopharmaceutical uptake in basal ganglia (caudate nuclei and putamina) is very useful to support the diagnostic process. An artificial neural network classifier using 123I-FP-CIT brain SPET data, a classification tree (CIT), was applied...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29318220/toxicokinetics-of-metformin-during-hemodialysis
#3
Paul Ayoub, Pierre-Olivier Hétu, Monique Cormier, Alexandre Benoit, Andrea Palumbo, Marie-Claude Dubé, Sophie Gosselin, Marc Ghannoum
No abstract text is available yet for this article.
July 2017: KI Reports
https://www.readbyqxmd.com/read/29306359/the-culturally-adapted-italian-version-of-the-barthel-index-icabi-assessment-of-structural-validity-inter-rater-reliability-and-responsiveness-to-clinically-relevant-improvements-in-patients-admitted-to-inpatient-rehabilitation-centers
#4
S F Castiglia, G Galeoto, A Lauta, A Palumbo, F Tirinelli, F Viselli, Valter Santilli, M L Sacchetti
The Barthel Index (BI) is widely used to determine eligibility criteria for inpatient rehabilitation and to monitor patients' recovery, irrespective of the illnesses that affect them. The culturally adapted Italian version of the Barthel Index (IcaBI) was recently validated. This paper reports the structural validity and inter-rater reliability of the IcaBI and its responsiveness to the results of inpatient rehabilitation. The IcaBI was administered to a cohort of 264 patients hospitalized in two rehabilitation centers in Rome, Italy...
October 2017: Functional Neurology
https://www.readbyqxmd.com/read/29296974/urokinase-plasminogen-activator-and-receptor-promote-collagen-induced-arthritis-through-expression-in-hematopoietic-cells
#5
Sherry Thornton, Harini Raghu, Carolina Cruz, Malinda D Frederick, Joseph S Palumbo, Eric S Mullins, Kasper Almholt, Pernille A Usher, Matthew J Flick
The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis pathogenesis remains poorly defined. Here, the role of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) in the development and severity of inflammatory joint disease was determined using uPA- and uPAR-deficient mice inbred to the strain DBA/1J, a genetic background highly susceptible to collagen-induced arthritis (CIA). Mice deficient in uPA displayed a near-complete amelioration of macroscopic and histological inflammatory joint disease following CIA challenge...
March 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295590/proposal-of-a-novel-natural-biomaterial-the-scleral-ossicle-for-the-development-of-vascularized-bone-tissue-in-vitro
#6
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone. The current standard treatments include allografting, autografting, and other bone implant techniques. However, although they are commonly used in orthopedic surgery, these treatments have some limitations concerning their costs and their side effects such as potential infections or malunions. On this account, the need for suitable constructs to fill the gap in wide fractures is still urgent...
December 25, 2017: Biomedicines
https://www.readbyqxmd.com/read/29285330/prosthetic-management-of-patients-with-oro-maxillo-facial-defects-a-long-term-follow-up-retrospective-study
#7
G Gastaldi, L Palumbo, C Moreschi, E F Gherlone, P Capparé
Introduction: The aim of this study is to determine the outcome of maxillofacial prosthetic rehabilitation after oncological resections, including both intra- and extra-oral prosthetic devices. Methods: In this study were included 72 patients, who have undergone an intra or extra-oral maxillofacial prosthetic rehabilitation after an oncologic resection. Tumors on the head and neck were analyzed and the defects of these resections have been divided in two different groups: intra and extra-oral defects...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29285222/a-primary-tumor-gene-expression-signature-identifies-a-crucial-role-played-by-tumor-stroma-myofibroblasts-in-lymph-node-involvement-in-oral-squamous-cell-carcinoma
#8
Gianluigi Mazzoccoli, Stefano Castellana, Massimo Carella, Orazio Palumbo, Cristiana Tiberio, Caterina Fusilli, Daniele Capocefalo, Tommaso Biagini, Tommaso Mazza, Lorenzo Lo Muzio
Oral squamous cell carcinoma (OSCC) is the most common oral and pharyngeal cancer, and is responsible of approximately 3% of cancers in men and 2% in women in the Western World, with increasing incidence rates in developing countries. Early detection by screening is necessary to prevent fatal disease because early, curable lesions are rarely symptomatic. The overall 5-yr survival rate is approximately 50% when surgery, radiation, or both are employed as treatment options, but lymph node involvement greatly influences this estimate, by decreasing the survival rate by about 50%...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29279323/the-hidden-genomic-and-transcriptomic-plasticity-of-giant-marker-chromosomes-in-cancer
#9
Gemma Macchia, Marco Severgnini, Stefania Purgato, Doron Tolomeo, Hilen Casciaro, Ingrid Cifola, Alberto L'Abbate, Anna Loverro, Orazio Palumbo, Massimo Carella, Laurence Bianchini, Giovanni Perini, Gianluca De Bellis, Fredrik Mertens, Mariano Rocchi, Clelia T Storlazzi
Genome amplification in the form of rings or giant rod-shaped marker chromosomes is a common genetic alteration in soft tissue tumours. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to cancer progression. Here, we disentangled the genomic architecture of many neocentromeres stabilizing marker chromosomes in well-differentiated liposarcoma and lung sarcomatoid carcinoma samples. In cells carrying heavily rearranged RGMs, these structures were assembled as patchworks of multiple short amplified sequences, disclosing an extremely high level of complexity and definitely ruling out the existence of regions prone to the neocentromere seeding...
December 26, 2017: Genetics
https://www.readbyqxmd.com/read/29279196/experimental-quantification-of-the-fluid-dynamics-in-blood-processing-devices-through-4d-flow-imaging-a-pilot-study-on-a-real-oxygenator-heat-exchanger-module
#10
Filippo Piatti, Maria Chiara Palumbo, Filippo Consolo, Francesca Pluchinotta, Andreas Greiser, Francesco Sturla, Emiliano Votta, Sergii V Siryk, Riccardo Vismara, Gianfranco Beniamino Fiore, Massimo Lombardi, Alberto Redaelli
The performance of blood-processing devices largely depends on the associated fluid dynamics, which hence represents a key aspect in their design and optimization. To this aim, two approaches are currently adopted: computational fluid-dynamics, which yields highly resolved three-dimensional data but relies on simplifying assumptions, and in vitro experiments, which typically involve the direct video-acquisition of the flow field and provide 2D data only. We propose a novel method that exploits space- and time-resolved magnetic resonance imaging (4D-flow) to quantify the complex 3D flow field in blood-processing devices and to overcome these limitations...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29274487/refinement-of-the-critical-7p22-1-deletion-region-haploinsufficiency-of-actb-is-the-cause-of-the-7p22-1-microdeletion-related-developmental-disorders
#11
Orazio Palumbo, Maria Accadia, Pietro Palumbo, Maria Pia Leone, Antonio Scorrano, Teresa Palladino, Raffaella Stallone, Maria Clara Bonaglia, Massimo Carella
Non-recurrent microdeletion (≤2 Mb in size) in 7p22.1 is a rarely described cytogenetic aberration, only recently reported in patients with developmental delay/intellectual disability, short stature and microcephaly. The size of the deletions ranged from 0.37 to 1.5 Mb, and reported genotype-phenotype correlations identified a minimum deleted region of 0.37 Mb involving the FBLX18, ACTB, FSCN1, RNF216 and ZNF815P genes. The authors suggested that deletion of ACTB, which encodes β-actin, an essential component of the cytoskeleton, could be responsible for the clinical features observed in the patients with a 7p22...
December 20, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29244836/energy-compensation-after-sprint-and-high-intensity-interval-training
#12
Matthew M Schubert, Elyse Palumbo, Rebekah F Seay, Katie K Spain, Holly E Clarke
BACKGROUND: Many individuals lose less weight than expected in response to exercise interventions when considering the increased energy expenditure of exercise (ExEE). This is due to energy compensation in response to ExEE, which may include increases in energy intake (EI) and decreases in non-exercise physical activity (NEPA). We examined the degree of energy compensation in healthy young men and women in response to interval training. METHODS: Data were examined from a prior study in which 24 participants (mean age, BMI, & VO2max = 28 yrs, 27...
2017: PloS One
https://www.readbyqxmd.com/read/29243531/impact-of-reward-and-loss-anticipation-on-cognitive-control-an-event-related-potential-study-in-subjects-with-schizophrenia-and-healthy-controls
#13
Annarita Vignapiano, Armida Mucci, Eleonora Merlotti, Giulia Maria Giordano, Antonella Amodio, Davide Palumbo, Silvana Galderisi
INTRODUCTION: Deficits of cognitive functions and motivation are core aspects of schizophrenia. The interaction of these deficits might contribute to impair the ability to flexibly adjust behavior in accordance with one's intentions and goals. Many studies have focused on the anterior N2 as a correlate of cognitive control based on motivational value. AIMS: Given the key role of motivation impairment in schizophrenia as a predictor of functional outcome, we aimed to study the impact of reward- and avoidance-based motivation on cognitive control using N2...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29242832/persistence-of-supplemented-bifidobacterium-longum-subsp-infantis-evc001-in-breastfed-infants
#14
Steven A Frese, Andra A Hutton, Lindsey N Contreras, Claire A Shaw, Michelle C Palumbo, Giorgio Casaburi, Gege Xu, Jasmine C C Davis, Carlito B Lebrilla, Bethany M Henrick, Samara L Freeman, Daniela Barile, J Bruce German, David A Mills, Jennifer T Smilowitz, Mark A Underwood
Attempts to alter intestinal dysbiosis via administration of probiotics have consistently shown that colonization with the administered microbes is transient. This study sought to determine whether provision of an initial course of Bifidobacterium longum subsp. infantis (B. infantis) would lead to persistent colonization of the probiotic organism in breastfed infants. Mothers intending to breastfeed were recruited and provided with lactation support. One group of mothers fed B. infantis EVC001 to their infants from day 7 to day 28 of life (n = 34), and the second group did not administer any probiotic (n = 32)...
November 2017: MSphere
https://www.readbyqxmd.com/read/29242336/improving-regulation-of-microbiota-transplants
#15
Diane Hoffmann, Francis Palumbo, Jacques Ravel, Mary-Claire Roghmann, Virginia Rowthorn, Erik von Rosenvinge
No abstract text is available yet for this article.
December 15, 2017: Science
https://www.readbyqxmd.com/read/29241881/ispor-code-of-ethics-2017-4th-edition
#16
Jessica Santos, Francis Palumbo, Elizabeth Molsen-David, Richard J Willke, Louise Binder, Michael Drummond, Anita Ho, William D Marder, Louise Parmenter, Gurmit Sandhu, Asrul A Shafie, David Thompson
As the leading health economics and outcomes research (HEOR) professional society, ISPOR has a responsibility to establish a uniform, harmonized international code for ethical conduct. ISPOR has updated its 2008 Code of Ethics to reflect the current research environment. This code addresses what is acceptable and unacceptable in research, from inception to the dissemination of its results. There are nine chapters: 1 - Introduction; 2 - Ethical Principles respect, beneficence and justice with reference to a non-exhaustive compilation of international, regional, and country-specific guidelines and standards; 3 - Scope HEOR definitions and how HEOR and the Code relate to other research fields; 4 - Research Design Considerations primary and secondary data related issues, e...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29234063/the-sam-sam-interaction-between-ship2-and-the-epha2-receptor-design-and-analysis-of-peptide-inhibitors
#17
Flavia Anna Mercurio, Concetta Di Natale, Luciano Pirone, Roberta Iannitti, Daniela Marasco, Emilia Maria Pedone, Rosanna Palumbo, Marilisa Leone
The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates with the Sam domain from the EphA2 receptor (EphA2-Sam). This interaction is expected to mainly induce pro-oncogenic effects in cells therefore, inhibition of the Ship2-Sam/EphA2-Sam complex may represent an innovative route to discover anti-cancer therapeutics. In the present work, we designed and analyzed several peptide sequences encompassing the interaction interface of EphA2-Sam for Ship2-Sam...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231969/patient-reported-outcomes-enhance-the-survival-prediction-of-traditional-disease-risk-classifications-an-international-study-in-patients-with-myelodysplastic-syndromes
#18
Fabio Efficace, Francesco Cottone, Gregory Abel, Pasquale Niscola, Gianluca Gaidano, Franck Bonnetain, Amelie Anota, Giovanni Caocci, Angel Cronin, Luana Fianchi, Massimo Breccia, Reinhard Stauder, Uwe Platzbecker, Giuseppe A Palumbo, Mario Luppi, Rosangela Invernizzi, Micaela Bergamaschi, Lorenza Borin, Anna Angela Di Tucci, Huiyong Zhang, Mirjam Sprangers, Marco Vignetti, Franco Mandelli
BACKGROUND: Current prognostic systems for myelodysplastic syndromes (MDS) are based on clinical, pathologic, and laboratory indicators. The objective of the current study was to develop a new patient-centered prognostic index for patients with advanced MDS by including self-reported fatigue severity into a well-established clinical risk classification: the International Prognostic Scoring System (IPSS). METHODS: A total of 469 patients with advanced (ie, IPSS intermediate-2 or high-risk) MDS were analyzed...
December 12, 2017: Cancer
https://www.readbyqxmd.com/read/29218828/monocytic-myeloid-derived-suppressor-cells-as-prognostic-factor-in-chronic-myeloid-leukaemia-patients-treated-with-dasatinib
#19
Cesarina Giallongo, Nunziatina L Parrinello, Piera La Cava, Giuseppina Camiolo, Alessandra Romano, Marina Scalia, Fabio Stagno, Giuseppe A Palumbo, Roberto Avola, Giovanni Li Volti, Daniele Tibullo, Francesco Di Raimondo
Myeloid suppressor cells are a heterogeneous group of myeloid cells that are increased in patients with chronic myeloid leukaemia (CML) inducing T cell tolerance. In this study, we found that therapy with tyrosine kinase inhibitors (TKI) decreased the percentage of granulocytic MDSC, but only patients treated with dasatinib showed a significant reduction in the monocytic subset (M-MDSC). Moreover, a positive correlation was observed between number of persistent M-MDSC and the value of major molecular response in dasatinib-treated patients...
December 8, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29218739/successful-liver-transplantation-for-homozygous-protein-c-deficiency-with-a-type-ii-mutation-using-a-heterozygous-living-related-donor
#20
Alexander A Boucher, Lori Luchtman-Jones, Jaimie D Nathan, Joseph S Palumbo
No abstract text is available yet for this article.
December 8, 2017: American Journal of Hematology
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