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Immacolata Castellano, Oriana Migliaccio, Giarita Ferraro, Elisa Maffioli, Daniela Marasco, Antonello Merlino, Adriana Zingone, Gabriella Tedeschi, Anna Palumbo
The major yolk protein toposome plays crucial roles during gametogenesis and development of sea urchins. We previously found that nitration of toposome increases in the gonads of a Paracentrotus lividus population living in a marine protected area affected by toxic blooms of Ostreospsis cf. ovata, compared to control populations. This modification is associated with ovatoxin accumulation, high levels of nitric oxide in the gonads, and a remarkable impairment of progeny development. However, nothing is known about the environmental-mediated-regulation of the structure and biological function of toposome...
March 15, 2018: Scientific Reports
Christopher N Morrison, Benjamin Ukert, Aimee Palumbo, Beidi Dong, Sara F Jacoby, Douglas J Wiebe
AIM: This study investigates whether assault frequency increased on days and in cities where candidates Donald Trump and Hillary Clinton held campaign rallies prior to the 2016 US Presidential election. METHOD: We calculated city-level counts of police-reported assaults for 31 rallies for Donald Trump and 38 rallies for Hillary Clinton. Negative binomial models estimated the assault incidence on rally days (Day 0) relative to that on 8 control days for the same city (Days -28, -21, -14, -7, +7, +14, +21, and +28)...
March 12, 2018: Epidemiology
Giulio Illuminati, Giulia Pizzardi, Rocco Pasqua, Francesca Frezzotti, Piergaspare Palumbo, Francesco Macrina, Francesco Calio
BACKGROUND: Tandem stenoses of the internal carotid artery (ICA) and proximal, ipsilateral common carotid artery (CCA) or innominate artery can be treated with a hybrid approach, combining conventional carotid endarterectomy (CEA) and retrograde stenting of the proximal stenosis, through surgical exposure of the carotid bifurcation. The purpose of this study was to evaluate the results of combining eversion CEA with retrograde CCA/innominate artery stenting. MATERIAL AND METHODS: From January 2015 to July 2017, 7 patients, 6 men of a mean age of 72 years (range 59-83 years) underwent simultaneous, retrograde stenting of the proximal CCA/innominate artery and an eversion CEA of the ipsilateral ICA, through surgical exposure of the carotid bifurcation, for severe tandem stenoses...
March 10, 2018: International Journal of Surgery
Julia M Leach, Sabato Mellone, Pierpaolo Palumbo, Stefania Bandinelli, Lorenzo Chiari
Although turning has been reported as one of the leading activities performed during a fall, and falls during turning result in 8-times more hip fractures than falls during linear gait, the quantity and quality of turns resulting in falls remain unknown since turns are rarely assessed during activities of daily living. 160 community-dwelling older adults were monitored for one week using smartphone technology. Turn measures and activity rates were quantified. Fall incidence within 12 months from continuous monitoring defined fall status, with 7/153 prospective fallers/non-fallers...
March 12, 2018: Scientific Reports
Francesca Palandri, Giulia Benevolo, Alessandra Iurlo, Elisabetta Abruzzese, Angelo M Carella, Chiara Paoli, Giuseppe A Palumbo, Massimiliano Bonifacio, Daniela Cilloni, Alessandro Andriani, Attilio Guarini, Diamante Turri, Elena Maria Elli, Antonietta Falcone, Barbara Anaclerico, Pellegrino Musto, Nicola Di Renzo, Mario Tiribelli, Renato Zambello, Caterina Spinosa, Alessandra Ricco, Letizia Raucci, Bruno Martino, Mario Annunziata, Silvia Pascale, Anna Marina Liberati, Giorgio La Nasa, Margherita Maffioli, Massimo Breccia, Novella Pugliese, Silvia Betti, Gianfranco Giglio, Antonietta Cappuccio, Luigi Reale
PURPOSE: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm characterised by an aggressive clinical course, with disabling symptoms and reduced survival. Patients experience a severely impaired quality of life and their families face the upheaval of daily routines and high disease-related financial costs. The aim of this study was to investigate the perceptions of Italian patients and their caregivers about living with MF and the burden of illness associated with MF. METHODS: A quali-quantitative questionnaire and a prompted written narrative survey were administered to patients affected by primary or post-essential thrombocythemia/post-polycythaemia vera MF and their primary caregiver in 35 Italian haematological centres...
March 8, 2018: Quality of Life Research
G Conte, S Milani, G Palumbo, G Talenti, S Boito, M Rustico, F Triulzi, A Righini, G Izzo, C Doneda, A Zolin, C Parazzini
BACKGROUND AND PURPOSE: Evaluation of biometry is a fundamental step in prenatal brain MR imaging. While different studies have reported reference centiles for MR imaging biometric data of fetuses in the late second and third trimesters of gestation, no one has reported them in fetuses in the early second trimester. We report centiles of normal MR imaging linear biometric data of a large cohort of fetal brains within 24 weeks of gestation. MATERIALS AND METHODS: From the data bases of 2 referral centers of fetal medicine, accounting for 3850 examinations, we retrospectively collected 169 prenatal brain MR imaging examinations of singleton pregnancies, between 20 and 24 weeks of gestational age, with normal brain anatomy at MR imaging and normal postnatal neurologic development...
March 8, 2018: AJNR. American Journal of Neuroradiology
Jessica Snowden, Paul Darden, Paul Palumbo, Phil Saul, Jeannette Lee
PURPOSE OF REVIEW: The institutional development award (IDeA) program was created to increase the competitiveness of investigators in states with historically low success rates for National Institutes of Health (NIH) research funding applications. IDeA states have high numbers of rural and medically underserved residents with disproportionately high rates of infant mortality, obesity, and poverty. This program supports the development and expansion of research infrastructure and research activities in these states...
April 2018: Current Opinion in Pediatrics
Nadia Napoli, Roberta Ghelli, Patrizia Brunetti, Angelo De Paolis, Valentina Cecchetti, Tomohiko Tsuge, Giovanna Serino, Minami Matsui, Giovanni Mele, Gianmarco Rinaldi, Gianna Aurora Palumbo, Fabrizio Barozzi, Paolo Costantino, Maura Cardarelli
In addition to the full-length transcript ARF8.1, a splice variant (ARF8.2) of the Auxin Response Factor gene ARF8 has been reported. Here, we identified an intron-retaining variant of ARF8.2, ARF8.4, whose translated product is imported into the nucleus and has tissue-specific localization in Arabidopsis thaliana. By inducibly expressing each variant in arf8-7 flowers, we show that ARF8.4 fully complements the short-stamen phenotype of the mutant and restores the expression of AUX/IAA19, encoding a key regulator of stamen elongation...
March 7, 2018: Plant Cell
A Tsurumaki, F Trequattrini, O Palumbo, S Panero, A Paolone, M A Navarra
The effect of ether-functionalisation on ionic liquids (ILs) is discussed based on Kamlet-Taft parameters and the infrared (IR) spectra of N-ethoxyethyl-N-methylpiperidinium bis(trifluoromethanesulfonyl)imide ([P1,2O2 ][TFSI]) and N-ethoxyethyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide ([M1,2O2 ][TFSI]). The results are analysed taking into consideration their ion conformers, electronegativity and hardness, and the IR active vibrations obtained by means of DFT calculations. From the evaluation of Kamlet-Taft parameters, the ether-functionalisation in the cationic ring is found to improve the polarity and hydrogen bond acidity of the ILs...
March 7, 2018: Physical Chemistry Chemical Physics: PCCP
Gianluca Neglia, Massimo Capuano, Anna Balestrieri, Roberta Cimmino, Francesco Iannaccone, Francesco Palumbo, Giorgio A Presicce, Giuseppe Campanile
The combined effect of six consecutive timed artificial inseminations (TAIs) on pregnancy rates, following two different synchronization protocols on buffalo heifers, over a period of seven months typically characterized by low breeding performances, were investigated in this study. A total of 2189 TAIs were performed on 1463 buffalo heifers within a large buffalo farm in the south of Italy. Individual animals were allowed to undergo synchronization protocol (either a slightly modified Ovsynch or Progesterone treatment) and TAI until establishment of pregnancy or else for not more than six consecutive times...
February 8, 2018: Theriogenology
Margaret A Gettis, Katherine Wittling, Jessica Palumbo-Dufur, Ashley McClain, Linda Riley
This column shares the best evidence-based strategies and innovative ideas on how to facilitate the learning and implementation of EBP principles and processes by clinicians as well as nursing and interprofessional students. Guidelines for submission are available at
February 27, 2018: Worldviews on Evidence-based Nursing
Gian Paolo Rossi, Giuseppe Maiolino, Alberto Flego, Anna Belfiore, Giampaolo Bernini, Bruno Fabris, Claudio Ferri, Gilberta Giacchetti, Claudio Letizia, Mauro Maccario, Francesca Mallamaci, Maria Lorenza Muiesan, Massimo Mannelli, Aurelio Negro, Gaetana Palumbo, Gabriele Parenti, Ermanno Rossi, Franco Mantero
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis in adrenalectomized and medically treated patients. We have, therefore, assessed the outcome of PA patients according to treatment mode in the PAPY study (Primary Aldosteronism Prevalence in Hypertension) patients, 88.8% of whom were optimally treated patients with primary (essential) hypertension (PH), and the rest had PA and were assigned to medical therapy (6...
February 26, 2018: Hypertension
Sara Bringhen, Roberto Mina, Anna Maria Cafro, Anna Marina Liberati, Stefano Spada, Angelo Belotti, Gianluca Gaidano, Francesca Patriarca, Rossella Troia, Renato Fanin, Lorenzo De Paoli, Giuseppe Rossi, Alessandra Lombardo, Paola Bertazzoni, Antonio Palumbo, Pieter Sonneveld, Mario Boccadoro
No abstract text is available yet for this article.
January 30, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Jillian R Palumbo, Shao Lin, Ziqiang Lin, Iulia A Neamtiu, Wangjian Zhang, Eva Csobod, Eugen S Gurzau
School environment may have an impact on children's health, but few studies have focused on indoor comfort factors such as temperature, humidity, and noise in relation with potential effects on children's health. Our cross-sectional study used data from the European Schools Indoor Pollution and Health Observatory Network in Europe (SINPHONIE) project to assess children's allergy, asthma-like symptoms, and flu-like symptoms in relation with classroom comfort and environmental factors. The study used self-reported data from three questionnaires to identify classroom conditions and student health outcomes for 280 students...
February 22, 2018: Environmental Science and Pollution Research International
Robert D Latzman, Isabella M Palumbo, Katheryn C Sauvigné, Lisa K Hecht, Scott O Lilienfeld, Christopher J Patrick
Methodological and conceptual differences across studies have impeded our understanding of the relationship between psychopathy and internalizing psychopathology. To shed further light on this question, we undertook correlational and structural-modeling analyses of data from two samples to characterize how facets of psychopathy relate to internalizing psychopathology when assessed using multidimensional measures of each construct (i.e., Triarchic Psychopathy Measure, Inventory of Depression and Anxiety Symptoms)...
February 22, 2018: Journal of Personality Disorders
Massimo Breccia, Francesca Palandri, Luigiana Luciano, Giulia Benevolo, Massimiliano Bonifacio, Giovanni Caocci, Fausto Castagnetti, Giuseppe A Palumbo, Alessandra Iurlo, Francesco Landi
The incidence of cancer, including myeloproliferative neoplasms (MPNs), is projected to increase significantly due to the growing proportion of people aged > 65 years. These older individuals are a heterogeneous population in terms of fitness, comorbidity, and psychological reserve. Therefore, age per se does not always provide an accurate indication of condition in patients with cancer. Frailty has been proposed as an alternative measure of vulnerability that might better indicate which patients can tolerate standard cancer treatment and those who may benefit from treatment adjustment...
February 22, 2018: Annals of Hematology
Alberto L Abbate, Doron Tolomeo, Ingrid Cifola, Marco Severgnini, Antonella Turchiano, Bartolomeo Augello, Gabriella Squeo, Pietro D Addabbo, Debora Traversa, Giulia Daniele, Angelo Lonoce, Mariella Pafundi, Massimo Carella, Orazio Palumbo, Anna Dolnik, Dominique Muehlematter, Jacqueline Schoumans, Nadine Van Roy, Gianluca De Bellis, Giovanni Martinelli, Giuseppe Merla, Lars Bullinger, Claudia Haferlach, Clelia Tiziana Storlazzi
Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolution genomic methods to investigate the architecture and expression pattern of amplicons involving chromosome band 8q24 in 23 cases of AML (AML-amp). This revealed that different MYC-dmin architectures can coexist within the same leukemic cell population, indicating a step-wise evolution rather than a single event origin, such as through chromothripsis...
February 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Martina Miceli, Andrea Mazziotta, Chiara Palumbo, Elia Roma, Eleonora Tosi, Giovanna Longhi, Sergio Abbate, Paolo Lupattelli, Giuseppe Mazzeo, Tecla Gasperi
Taking into account the postulated reaction mechanism for the organocatalytic epoxidation of electron-poor olefins developed by our laboratory, we have investigated the key factors able to positively influence the H-bond network installed inside the substrate/catalyst/oxidizing agent. With this aim, we have: (i) tested a few catalysts displaying various effects that noticeably differ in terms of steric hindrance and electron demand; (ii) employed α-alkylidene oxindoles decorated with different substituents on the aromatic ring ( 11a - g ), the exocylic double bond ( 11h - l ), and the amide moiety ( 11m - v )...
February 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Chad T Palumbo, Dominik P Halter, Vamsee K Voora, Guo P Chen, Alan K Chan, Megan E Fieser, Joseph W Ziller, Wolfgang Hieringer, Filipp Furche, Karsten Meyer, William J Evans
The synthesis of 4fn Ln3+ complexes of the tris(aryloxide) mesitylene ligand, ((Ad,Me ArO)3 mes)3- , with Ln = La, Ce, Pr, Sm, and Yb, and their reduction with potassium have revealed that this ligand system can be redox active with some metals. Protonolysis of [Ln(N(SiMe3 )2 )3 ] (Ln = La, Ce, Pr, Sm, Yb) with the tris(phenol) (Ad,Me ArOH)3 mes yielded the Ln3+ complexes [((Ad,Me ArO)3 mes)Ln] (Ln = La, Ce, Pr, Sm, Yb), 1-Ln. Single electron reduction of each 4fn complex, 1-Ln, using potassium yielded the reduced products, [K(2...
February 19, 2018: Inorganic Chemistry
Jennifer P Pascali, Paolo Fais, Fabio Vaiano, Nicola Pigaiani, Stefano D'Errico, Sandra Furlanetto, Diego Palumbo, Elisabetta Bertol
Drug tampering practices, with the aim to increase availability of drug delivery and/or enhance drug effects, are accessible on Internet and are practiced by some portion of recreational drug users. Not rarely, recreational misuse may result in toxic and even fatal results. The aim of the present study was to assess the tampering risk of medicaments containing different formulations of an opioid in combination with paracetamol or dexketoprofen, following the procedures reported in dedicated forums on the web...
February 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
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