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https://www.readbyqxmd.com/read/28430336/an-italian-translation-and-validation-of-the-near-activity-visual-questionnaire-navq
#1
Fabrizio Zeri, Isabella Beltramo, Laura Boccardo, Paolo Palumbo, Vincenzo Petitti, James S Wolffsohn, Shehzad A Naroo
PURPOSE: To validate the Near Activity Vision Questionnaire (NAVQ) in Italian to allow the assessment of presbyopia corrections in Italian-speaking patients. METHODS: An Italian version of the NAVQ was arranged through several steps: an initial forward translation (from English to Italian), a backward translation (from Italian to English), and finally a consensual version to check against the original NAVQ. This prospective study enrolled native Italian-speaking presbyopic patients with corrected distance visual acuity of 0...
April 11, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28430175/carfilzomib-lenalidomide-dexamethasone-vs-lenalidomide-dexamethasone-in-relapsed-multiple-myeloma-by-previous-treatment
#2
M A Dimopoulos, A K Stewart, T Masszi, I Špička, A Oriol, R Hájek, L Rosiñol, D Siegel, G G Mihaylov, V Goranova-Marinova, P Rajnics, A Suvorov, R Niesvizky, A Jakubowiak, J San-Miguel, H Ludwig, S Ro, S Aggarwal, P Moreau, A Palumbo
Carfilzomib, a proteasome inhibitor, is approved as monotherapy and in combination with dexamethasone or lenalidomide-dexamethasone (Rd) for relapsed or refractory multiple myeloma. The approval of carfilzomib-lenalidomide-dexamethasone (KRd) was based on results from the randomized, phase 3 study ASPIRE (NCT01080391), which showed KRd significantly improved progression-free survival (PFS) vs Rd (median 26.3 vs 17.6 months; hazard ratio (HR)=0.690; P=0.0001). This subgroup analysis of ASPIRE evaluated KRd vs Rd by number of previous lines of therapy and previous exposure to bortezomib, thalidomide or lenalidomide...
April 21, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28429248/time-in-therapeutic-range-as-a-marker-for-thrombotic-and-bleeding-outcomes-in-fontan-patients
#3
Jenna M Faircloth, Kristin M Miner, Tarek Alsaied, Nicole Nelson, Julie Ciambarella, Tomoyuki Mizuno, Joseph S Palumbo, Alexander A Vinks, Gruschen R Veldtman
Fontan patients managed with warfarin are at risk not only for thrombotic events, but also for bleeding episodes as a consequence of anticoagulation treatment. The aim of this study was to determine whether time spent in patient specified therapeutic range (TTR), when managed in a cardiology-based pharmacist managed anticoagulation clinic (PMAC), is a useful target metric for monitoring, as well as improving outcomes. A single center retrospective review was conducted evaluating TTR of all Fontan patients (n = 45) on warfarin managed in our outpatient cardiology pharmacist managed anticoagulation clinic (PMAC) during a 19 month time frame...
April 20, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28424427/nos2-expression-in-glioma-cell-lines-and-glioma-primary-cell-cultures-correlation-with-neurosphere-generation-and-sox-2-expression
#4
Paola Palumbo, Gianfranca Miconi, Benedetta Cinque, Francesca Lombardi, Cristina La Torre, Soheila Raysi Dehcordi, Renato Galzio, Annamaria Cimini, Antonio Giordano, Maria Grazia Cifone
Nitric oxide has been implicated in biology and progression of glioblastoma (GBM) being able to influence the cellular signal depending on the concentration and duration of cell exposure. NOS2 (inducible nitric oxide synthase) have been proposed as a component of molecular profile of several tumors, including glioma, one of the most aggressive primary brain tumor featuring local cancer stem cells responsible for enhanced resistance to therapies and for tumor recurrence. Here, we investigated the NOS2 mRNA expression by reverse transcription-PCR in human glioma primary cultures at several grade of malignancy and glioma stem cell (GSC) derived neurospheres...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420131/work-characteristics-associated-with-physical-functioning-in-women
#5
Aimee J Palumbo, Anneclaire J De Roos, Carolyn Cannuscio, Lucy Robinson, Jana Mossey, Julie Weitlauf, Lorena Garcia, Robert Wallace, Yvonne Michael
Women make up almost half of the labor force with older women becoming a growing segment of the population. Work characteristics influence physical functioning and women are at particular risk for physical limitations. However, little research has explored the effects of work characteristics on women's physical functioning. U.S. women between the ages of 50 and 79 were enrolled in the Women's Health Initiative Observational Study between 1993 and 1998. Women provided job titles and years worked at their three longest-held jobs (n = 79,147)...
April 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28415115/p981lvot-area-measurement-using-gated-ct-data-reclassifies-aortic-stenosis-severity-as-graded-by-echocardiography
#6
L Moderato, A Palumbo, S Coli, D Orlandini, G Russo, N Gaibazzi
Background: Measurement of left ventricular outflow tract (LVOT) diameter and area for estimation of aortic valve area (AVA) using transthoracic echocardiography (TTE) and the continuity equation assumes circular LVOT. The use of direct planimetric measurement of LVOT area by gated-CT can theoretically improve accuracy of AVA calculation. Purpose: We aim to assess reproducibility of LVOT echo measurement and its correlation and agreement with Gated CT measurements...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411256/epigenetically-induced-ectopic-expression-of-uncx-impairs-the-proliferation-and-differentiation-of-myeloid-cells
#7
Giulia Daniele, Giogia Simonetti, Caterina Fusilli, Ilaria Iacobucci, Angelo Lonoce, Antonio Palazzo, Mariana Lomiento, Fabiana Mammoli, Rene' Massimiliano Marsano, Elena Marasco, Vilma Mantovani, Hilmar Quentmeier, Hans G Drexler, Jie Ding, Orazio Palumbo, Massimo Carella, Niroshan Nadarajah, Margherita Perricone, Emanuela Ottaviani, Carmen Baldazzi, Nicoletta Testoni, Cristina Papayannidis, Sergio Ferrari, Tommaso Mazza, Giovanni Martinelli, Clelia Tiziana Storlazzi
We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia. We found the ectopic activation of UNCX in a leukemia patient harboring a t(7;10)(p22;p14) translocation, in 22/61 of additional cases [a total of 23 positive patients out of 62 (37.1%)], and in 6/75 (8%) of acute myeloid leukemia cell lines. UNCX is embedded within a low-methylation region (canyon) and encodes for a transcription factor involved in somitogenesis and neurogenesis, with specific expression in the eye, brain, and kidney...
April 14, 2017: Haematologica
https://www.readbyqxmd.com/read/28407409/clinical-and-molecular-characterization-of-a-second-family-with-the-12q14-microdeletion-syndrome-and-review-of-the-literature
#8
Rita Fischetto, Orazio Palumbo, Federica Ortolani, Pietro Palumbo, Maria Pia Leone, Francesco Andrea Causio, Sabino Pesce, Maria Christina Digilio, Massimo Carella, Francesco Papadia
The 12q14 microdeletion syndrome is a rare condition characterized by low birth weight, failure to thrive, short stature, learning disabilities, and osteopoikilosis. To date, 20 cases of 12q14 deletion have been reported in the literature, displaying both phenotypic than genetic variability. We report on three familial cases, a mother and two brothers, with severe short stature. The mother and elder brother presented with osteopoikilosis while the younger brother had severe short stature and developmental delay...
April 13, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28406045/a-methacrylic-hyaluronic-acid-derivative-for-potential-application-in-oral-treatment-of-celiac-disease
#9
Giovanna Pitarresi, Fabio Salvatore Palumbo, Daniela Triolo, Calogero Fiorica, Gaetano Giammona
OBJECTIVE: Aim of this work was the synthesis of a methacrylic hyaluronic acid derivative and the production, via photocrosslinking, of related hydrogels loaded with an endopeptidase intended for a potential oral treatment of celiac disease. METHODS: The methacrylic derivative of hyaluronic acid (HA) was prepared through a one-pot procedure involving the reaction with ethylenediamine (EDA) and methacrylic anhydride (MA). The obtained derivative, named HA-EDA-MA, was used to prepare photocrosslinked hydrogels loaded with a prolyl endopeptidase derived from Flavobacterium meningosepticum (PEP FM) able to detoxify gliadin...
April 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28401095/a-neutrophil-phagocytosing-bacteria
#10
Fabio Miglietta, Claudio Palumbo, Maria Aguglia, Giambattista Lobreglio
No abstract text is available yet for this article.
March 2017: Blood Research
https://www.readbyqxmd.com/read/28398311/nextflow-enables-reproducible-computational-workflows
#11
Paolo Di Tommaso, Maria Chatzou, Evan W Floden, Pablo Prieto Barja, Emilio Palumbo, Cedric Notredame
No abstract text is available yet for this article.
April 11, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/28386015/lncatlas-database-for-subcellular-localisation-of-long-noncoding-rnas
#12
David Mas-Ponte, Joana Carlevaro-Fita, Emilio Palumbo, Toni Hermoso Pulido, Roderic Guigo, Rory Johnson
The subcellular localisation of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localisation of newly-discovered lncRNAs involves time-consuming and costly experimental methods. We have created "LncATLAS", a comprehensive resource of lncRNA localisation in human cells based on RNA-sequencing datasets. Altogether, 6,768 GENCODE-annotated lncRNAs are represented across various compartments of 15 cell lines. We introduce "Relative concentration index" (RCI) as a useful measure of localisation derived from ensemble RNAseq measurements...
April 6, 2017: RNA
https://www.readbyqxmd.com/read/28385234/hyaluronic-acid-and-beta-cyclodextrins-films-for-the-release-of-corneal-epithelial-cells-and-dexamethasone
#13
Calogero Fiorica, Fabio Salvatore Palumbo, Giovanna Pitarresi, Flavia Bongiovì, Gaetano Giammona
In this work we prepared hydrogels based on hyaluronic acid and β-cyclodextrins to sustain the release of both corneal epithelial cells and dexamethasone. This steroid is administered as eye drops several times per day to reduce the risk of rejection in the post operative period after the cornea transplantation and cell release techniques. Hydrogels were produced by crosslinking an amino derivative of hyaluronic acid, with the divinyl sulfone derivative of β-cyclodextrins, this last employed as a crosslinker and solubilizing agent...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28383630/the-medical-and-surgical-treatment-in-secondary-and-tertiary-hyperparathyroidism-review
#14
G Cocchiara, S Fazzotta, V D Palumbo, G Damiano, M Cajozzo, C Maione, S Buscemi, G Spinelli, S Ficarella, A Maffongelli, F Caternicchia, A Ignazio Lo Monte, G Buscemi
INTRODUCTION: Hyperparathyroidism is an alteration of the pathophysiological parathyroid hormone (PTH) secretion due or an independent and abnormal release (primary or tertiary hyperparathyroidism) by the parathyroid or an alteration of calcium homeostasis that stimulates the excessive production of parathyroid hormone (secondary hyperparathyroidism). AIMS: There is not a standard, clinical or surgical, treatment for hyperparathyroidism. We review current diagnostic and therapeutic methods...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28383625/the-saxophonist-s-hernia-a-rare-case-report-of-anterior-primary-perineal-hernia-in-a-young-male-patient
#15
V D Palumbo, B Di Trapani, B Molinelli, S Tomasini, A Bruno, G Tomasello
Perineal hernia is the protrusion of an intra-abdominal structure into the perineal area, that could be primitive or secondary to trauma or abdominoperineal resection. Main treatment could be transabdominal, transperineal or combined. Here is a rare case of anterior perineal hernia in a young saxophone male patient, treated with a mininvasive perineal approach. A 25-year-old Caucasian male patient referred 1-year history of perineal pain. The pain was more severe when he played his saxophone. Local exam was negative but a dynamic perineal ultrasonography revealed a small anterior perineal hernia...
March 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28377642/computer-navigation-and-distal-femoral-reconstruction-in-the-oncologic-patient
#16
Brian T Palumbo, Eric Henderson, Justin Rizer, Douglas G Letson, David Cheong
OBJECTIVES: As adjuvant treatments for musculoskeletal malignancies improve expectations of preserved function increase. We questioned whether computer navigation for distal femoral reconstruction would improve outcomes. METHODS: Twenty oncology patients were reviewed after distal femoral reconstruction using navigation. Outcomes included local recurrence, implant revision, patient function, patellofemoral complications and leg-length inequality. RESULTS: Implant survivorship was 85% at 26 months...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28373841/brain-transcriptome-sequencing-of-a-natural-model-of-alzheimer-s-disease
#17
Francisco Altimiras, Barbara Uszczynska-Ratajczak, Francisco Camara, Anna Vlasova, Emilio Palumbo, Stephen Newhouse, Robert M J Deacon, Leandro A E Farias, Michael J Hurley, David E Loyola, Rodrigo A Vásquez, Richard Dobson, Roderic Guigó, Patricia Cogram
No abstract text is available yet for this article.
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28367300/renal-and-hepatic-functions-after-a-week-of-controlled-ovarian-hyperstimulation-during-in-vitro-fertilization-cycles
#18
Ilaria Romito, Ferdinando Antonio Gulino, Antonio Simone Laganà, Salvatore Giovanni Vitale, Attilio Tuscano, Gianluca Leanza, Giulia Musmeci, Vito Leanza, Agnese Maria Chiara Rapisarda, Marco Antonio Palumbo
BACKGROUND: One the main aspects of in vitro fertilization (IVF) cycle is to avoid any possible systemic damage on women undergoing a controlled ovarian hyperstimulation (COH). The aim of this work is to evaluate renal and hepatic function blood tests in patients undergoing controlled ovarian hyperstimulation during IVF cycles. MATERIALS AND METHODS: We performed a prospective cohort analysis. All patients re- ceived a long stimulation protocol with gonadotropin-releasing hormone (GnRH) analogues by daily administration, since the twenty-first day of the previous ovarian cycle followed by COH with recombinant follicle-stimulating hormone (FSH)...
April 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28366406/nab-paclitaxel-in-advanced-her2-negative-breast-cancer-patients-efficacy-and-safety-beyond-clinical-trials
#19
Antonio Bernardo, Raffaella Palumbo, Rebecca Pedersini, Elena Rota Caremoli, Anna Rita Gambaro, Antonella Ferzi, Francesca Riva, Donatella Grasso, Marco Danova, Emiliana Tarenzi, Valter Torri, Marina E Cazzaniga
BACKGROUND: Few data are available regarding efficacy and safety of nanoparticle albumin-bound (nab)-paclitaxel in advanced breast cancer patients outside a controlled trial, especially for the weekly schedule. PATIENTS AND METHODS: We prospectively collected data of advanced breast cancer patients who were candidates to be treated with weekly (125 mg/m(2) for 3 consecutive weeks followed by a 1-week rest) or every 3 weeks (260 mg/m(2)) schedules of nab-paclitaxel, according to physician's decision...
March 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28346132/electronic-health-record-s-effects-on-the-outpatient-office-visit-and-clinical-education
#20
Marie B Sandoval, Mary Val Palumbo, Vicki Hart
BACKGROUND: During an office visit, the provider has the important cognitive task of attending to the patient while actively using the electronic health record (EHR).  Prior literature suggests that EHR may have a positive effect on simple tasks, but a negative effect on tasks that require complex cognitive processes.  No study has examined the provider's perception of EHR on multiple distinct aspects of the office visit. METHODS: We surveyed providers/preceptors regarding their perception of EHR on multiple aspects of the office visit...
January 24, 2017: Journal of Innovation in Health Informatics
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