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Alessandro Borri, Pasquale Palumbo, Abhyudai Singh
Synthetic biology combines different branches of biology and engineering aimed at designing synthetic biological circuits able to replicate emergent properties useful for the biotechnology industry, human health and environment. The role of negative feedback in noise propagation for a basic enzymatic reaction scheme is investigated. Two feedback control schemes on enzyme expression are considered: one from the final product of the pathway activity, the other from the enzyme accumulation. Both schemes are designed to provide the same steady-state average values of the involved players, in order to evaluate the feedback performances according to the same working mode...
October 2016: IET Systems Biology
Giulio Illuminati, Francesco G Calio', Giulia Pizzardi, Chiara Amatucci, Federica Masci, Piergaspare Palumbo
INTRODUCTION: Intra and perioperative anticoagulation in patients with heparin induced thrombocytopenia (HIT), candidates for peripheral vascular surgery remains a challenge, as the best alternative to heparin has not yet been established. We evaluated the off-label use of fondaparinux in four patients with HIT, undergoing peripheral vascular surgery procedures. PRESENTATION OF CASES: Four patients of whom 3 men of a mean age of 66 years, with proven heparin induced thrombocytopenia (HIT) underwent two axillo-femoral bypasses, one femoro-popliteal bypass and one resection of a splenic artery aneurysm under fondaparinux...
October 8, 2016: International Journal of Surgery Case Reports
Ornella Affinito, Giovanni Scala, Domenico Palumbo, Ermanno Florio, Antonella Monticelli, Gennaro Miele, Vittorio Enrico Avvedimento, Alessandro Usiello, Lorenzo Chiariotti, Sergio Cocozza
DNA methylation is often analyzed by reporting the average methylation degree of each cytosine. In this study, we used a single molecule methylation analysis in order to look at the methylation conformation of individual molecules. Using D-aspartate oxidase as a model gene, we performed an in-depth methylation analysis through the developmental stages of three different mouse tissues (brain, lung, and gut), where this gene undergoes opposite methylation destiny. This approach allowed us to track both methylation and demethylation processes at high resolution...
October 17, 2016: Epigenetics: Official Journal of the DNA Methylation Society
Giuliano Palumbo, Giuseppe Di Lorenzo, Margaret Ottaviano, Vincenzo Damiano
No abstract text is available yet for this article.
October 7, 2016: Future Oncology
Alexis D J Makin, Damien Wright, Giulia Rampone, Letizia Palumbo, Martin Guest, Rhiannon Sheehan, Helen Cleaver, Marco Bertamini
A traditional line of work starting with the Gestalt school has shown that patterns vary in strength and salience; a difference in "Perceptual goodness." The Holographic weight of evidence model quantifies goodness of visual regularities. The key formula states that W = E/N, where E is number of holographic identities in a pattern and N is number of elements. We tested whether W predicts the amplitude of the neural response to regularity in an extrastriate symmetry-sensitive network. We recorded an Event Related Potential (ERP) generated by symmetry called the Sustained Posterior Negativity (SPN)...
October 4, 2016: Cerebral Cortex
Guillemette Fouquet, Francesca Gay, Eileen Boyle, Sara Bringhen, Alessandra Larocca, Thierry Facon, Xavier Leleu, Antonio Palumbo
Multiple myeloma (MM) is a disease of the elderly, with a median age at diagnosis of approximately 70 years old, and more than 30 % of patients aged >75 years. This latter and very elderly population is going to significantly rise in the near future given the increase in life expectancy in Western countries, and, most importantly, global health status of elderly patients is improving, justifying appropriate treatments. Changes in treatment paradigm from the old melphalan-prednisone regimen used since the 1970s to its use as a backbone in a nontransplant setting since the late 1990s have highlighted different subgroups in elderly MM...
2016: Cancer Treatment and Research
Jairo Hernández, Adela Rodríguez-Fuentes, Maria Puopolo, Angela Palumbo
The aim of this study was to investigate whether the automatic measurement of follicular volume by three-dimensional (3D) ultrasound can predict the number of mature oocytes retrieved. A prospective cohort study including 47 women undergoing in vitro fertilization was conducted in a private fertility center. Follicular growth was monitored both manually and automatically using 3D scanning with SonoAVC on the day of human chorionic gonadotropin (hCG) administration. Regression analysis showed that under a standard protocol for hCG administration, the count of mature oocytes is well predicted by a multivariate model including the counts of follicles in the volume classes 2...
September 29, 2016: Reproductive Sciences
M van de Velden, A Iodice D'Enza, F Palumbo
A method is proposed that combines dimension reduction and cluster analysis for categorical data by simultaneously assigning individuals to clusters and optimal scaling values to categories in such a way that a single between variance maximization objective is achieved. In a unified framework, a brief review of alternative methods is provided and we show that the proposed method is equivalent to GROUPALS applied to categorical data. Performance of the methods is appraised by means of a simulation study. The results of the joint dimension reduction and clustering methods are compared with the so-called tandem approach, a sequential analysis of dimension reduction followed by cluster analysis...
September 28, 2016: Psychometrika
Michele Scialpi, Luisa Pierotti, Sabrina Gravante, Alberto Rebonato, Irene Piscioli, Alfredo D'Andrea, Raffaele Schiavone, Barbara Palumbo
BACKGROUND: In oncologic patients, the liver is the most common target for metastases. An accurate detection and characterization of focal liver lesions in patients with known primary extrahepatic malignancy are essential to define management and prognosis. OBJECTIVES: To assess the diagnostic accuracy of the split-bolus multidetector-row computed tomography (MDCT) protocol in the characterization of focal liver lesions in oncologic patients. PATIENTS AND METHODS: We retrospectively analyzed the follow-up split-bolus 64-detector row CT protocol in 36 oncologic patients to characterize focal liver lesions...
April 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Rosanna Palumbo, Marta Gogliettino, Ennio Cocca, Roberta Iannitti, Annamaria Sandomenico, Menotti Ruvo, Marco Balestrieri, Mosè Rossi, Gianna Palmieri
The proteasome is a multienzymatic complex that controls the half-life of the majority of intracellular proteins, including those involved in apoptosis and cell-cycle progression. Recently, proteasome inhibition has been shown to be an effective anticancer strategy, although its downregulation is often accompanied by severe undesired side effects. We previously reported that the inhibition of acylpeptide hydrolase (APEH) by the peptide SsCEI 4 can significantly affect the proteasome activity in A375 melanoma or Caco-2 adenocarcinoma cell lines, thus shedding new light on therapeutic strategies based on downstream regulation of proteasome functions...
2016: International Journal of Molecular Sciences
Davide Gianfreda, Alessandro A Palumbo, Enrica Rossi, Lorenzo Buttarelli, Gaia Manari, Chiara Martini, Massimo De Filippo, Augusto Vaglio
No abstract text is available yet for this article.
September 23, 2016: Blood
Massimo Offidani, Silvia Gentili, Francesca Gay, Elena Aghemo, Laura Maracci, Laura Corvatta, Antonio Palumbo
High-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains the standard of care for patients younger than 65 years of age with multiple myeloma (MM). However, this therapeutic approach has undergone substantial advances in this last decade, mainly due to the introduction of new drugs such as thalidomide, lenalidomide and bortezomib. These new drugs, in different combinations, have shown to significantly increase response rates after induction therapy and ASCT. Moreover, the positive results obtained with these agents in consolidation and maintenance strategies after ASCT strongly support the concept of continuous therapy, whose ultimate goal is the long-term control of the disease and the improvement of outcome...
September 19, 2016: Current Cancer Drug Targets
Letizia Palumbo, Ruth Ogden, Alexis D J Makin, Marco Bertamini
Repetitive prestimulation, in the form of click trains, is known to alter a wide range of cognitive and perceptual judgments. To date, no research has explored whether click trains also influence subjective preferences. This is plausible because preference is related to perceptual fluency and clicks may increase fluency, or, because preference is related to arousal and clicks may increase arousal. In Experiment 1, participants heard a click train, white noise, or silence through headphones and then saw an abstract symmetrical pattern on the screen for 0...
October 2015: I-Perception
Nicola Mammarella, Alberto Di Domenico, Rocco Palumbo, Beth Fairfield
Numerous studies have reported age-related differences in memory for emotional information. One explanation places emphasis on an emotion processing preference in older adults that reflects their socioemotional self-relevant goals. Here, we evaluate the degree to which this preference in memory may be modulated by color. In 2 experiments, younger and older adults were asked to study a series of affective words (Experiment 1) or affective pictures (Experiment 2) and then presented with an immediate yes/no memory recognition task...
September 15, 2016: Psychology and Aging
Vincenzo Davide Palumbo, Marcello Romeo, Antonella Marino Gammazza, Francesco Carini, Provvidenza Damiani, Giuseppe Damiano, Salvatore Buscemi, Attilio Ignazio Lo Monte, Alice Gerges-Geagea, Abdo Jurjus, Giovanni Tomasello
AIM: Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics seems to represent the proper support against their occurrence. Actually, probiotic blends and anti-inflammatory drugs represent a weapon against inflammatory bowel diseases. The present study evaluates the long-term (2 years) effects of combination therapy (mesalazine plus a probiotic blend of Lactobacillus salivarius, Lactobacillus acidophilus and Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Cynthia Aristei, Alessandra Carotti, Elisa Palazzari, Lucia Amico, Loredana Ruggeri, Elisabetta Perrucci, Lorenzo Falcinelli, Valentina Lancellotta, Isabella Palumbo, Franca Falzetti, Franco Aversa, Mara Merluzzi, Andrea Velardi, Massimo Fabrizio Martelli
PURPOSE: We sought to determine whether the total body irradiation (TBI) schedule affected outcome in patients with acute leukemia in complete remission who received T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA identical siblings. METHODS AND MATERIALS: The study recruited 55 patients (median age, 48 years; age range, 20-66 years; 30 men and 25 women; 34 with acute myeloid leukemia and 21 with acute lymphoid leukemia). Hyperfractionated TBI (HTBI) (1...
July 27, 2016: International Journal of Radiation Oncology, Biology, Physics
Jian Xu, Anthony Palumbo, Wei Xu, Eui-Hyeok Yang
We present a systematic study on the effects of electropolymerization parameters of polypyrrole-dodecylbenzenesulfonate (PPy(DBS)) surfaces on the flattening behaviors of organic droplets during reduction and oxidation (redox). PPy(DBS) surfaces were fabricated under varying electropolymerization conditions, including voltage, surface charge density, and dopant electrolyte (DBS(-)) concentration. The flattening behaviors on different PPy(DBS) surfaces were characterized by analyzing droplet behaviors and energy-dispersive X-ray spectroscopy (EDS) data...
October 6, 2016: Journal of Physical Chemistry. B
Jeffrey D Palumbo, Teresa L O'Keeffe, Matthew W Fidelibus
Identification of populations of Aspergillus section Nigri species in environmental samples using traditional methods is laborious and impractical for large numbers of samples. We developed species-specific primers and probes for quantitative droplet digital PCR (ddPCR) to improve sample throughput and simultaneously detect multiple species in each sample. The ddPCR method was used to distinguish A. niger, A. welwitschiae, A. tubingensis and A. carbonarius in mixed samples of total DNA. Relative abundance of each species measured by ddPCR agreed with input ratios of template DNAs...
September 7, 2016: Letters in Applied Microbiology
Carol Smith, Anne M Stringer, Chunhong Mao, Michael J Palumbo, Joseph T Wade
UNLABELLED: Salmonella enterica pathogenicity island 1 (SPI-1) encodes proteins required for invasion of gut epithelial cells. The timing of invasion is tightly controlled by a complex regulatory network. The transcription factor (TF) HilD is the master regulator of this process and senses environmental signals associated with invasion. HilD activates transcription of genes within and outside SPI-1, including six other TFs. Thus, the transcriptional program associated with host cell invasion is controlled by at least 7 TFs...
2016: MBio
Alessandra Larocca, Antonio Palumbo
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
September 6, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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