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https://www.readbyqxmd.com/read/27913192/the-cellular-protein-nucleolin-preferentially-binds-long-looped-g-quadruplex-nucleic-acids
#1
Sara Lago, Elena Tosoni, Matteo Nadai, Manlio Palumbo, Sara N Richter
BACKGROUND: G-quadruplexes (G4s) are four-stranded nucleic acid structures that form in G-rich sequences. Nucleolin (NCL) is a cellular protein reported for its functions upon G4 recognition, such as induction of neurodegenerative diseases, tumor and virus mechanisms activation. We here aimed at defining NCL/G4 binding determinants. METHODS: Electrophoresis mobility shift assay was used to detect NCL/G4 binding; circular dichroism to assess G4 folding, topology and stability; dimethylsulfate footprinting to detect G bases involved in G4 folding...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27912894/self-generation-and-positivity-effects-following-transcranial-random-noise-stimulation-in-medial-prefrontal-cortex-a-reality-monitoring-task-in-older-adults
#2
Nicola Mammarella, Alberto Di Domenico, Rocco Palumbo, Beth Fairfield
Activation of medial Prefrontal Cortex (mPFC) has been typically found during reality monitoring tasks (i.e., distinguishing between internal self-generated vs external information). No study, however, has yet investigated whether transcranial Random Noise Stimulation (tRNS) over the mPFC leads to a reduction in reality-monitoring misattributions in aging. In particular, stimulating mPFC should increase the number of cognitive operations engaged while encoding and this distinctive information may help older adults to discriminate between internal and external sources better...
November 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27906741/halo-vest-immobilization-in-elderly-odontoid-fracture-patients-evolution-in-treatment-modality-and-in-hospital-outcomes
#3
J Mason DePasse, Mark A Palumbo, Abdul-Kareem Ahmed, Charles A Adams, Alan H Daniels
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To evaluate the utilization and effectiveness of halo-vest (HV) immobilization for type II odontoid fractures from 2004 to 2014. SUMMARY OF BACKGROUND DATA: Controversy persists regarding the optimal treatment method for odontoid fractures in the elderly. Management options include immobilization in a cervical orthosis, HV immobilization, and operative intervention. Over the past decade, high mortality and morbidity rates have been reported following HV immobilization in this patient population...
November 30, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27900700/platelet-rich-plasma-supplementation-in-arthroscopic-repair-of-full-thickness-rotator-cuff-tears-a-randomized-clinical-trial
#4
R D'Ambrosi, F Palumbo, A Paronzini, V Ragone, R M Facchini
BACKGROUND: Results on the effectiveness of PRP supplementation in arthroscopic rotator cuff repair are conflicting, making it difficult to draw definitive conclusions. METHODS: This was a prospective, randomized, and double-blind study with two groups of 20 patients each (PRP group and control group). Degenerative supraspinatus full-thickness tears grade C2-C3 were subjected to arthroscopic repair; PRP supplementation was given to patients in the PRP group. The outcomes were assessed by DASH, Constant scales, and ultrasound before and 6 months after surgery...
December 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27899339/engaging-moms-on-teen-indoor-tanning-through-social-media-protocol-of-a-randomized-controlled-trial
#5
Sherry L Pagoto, Katie Baker, Julia Griffith, Jessica L Oleski, Ashley Palumbo, Barbara J Walkosz, Joel Hillhouse, Kimberly L Henry, David B Buller
BACKGROUND: Indoor tanning elevates the risk for melanoma, which is now the most common cancer in US women aged 25-29. Public policies restricting access to indoor tanning by minors to reduce melanoma morbidity and mortality in teens are emerging. In the United States, the most common policy restricting indoor tanning in minors involves parents providing either written or in person consent for the minor to purchase a tanning visit. The effectiveness of this policy relies on parents being properly educated about the harms of indoor tanning to their children...
November 29, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27896230/evaluation-of-symptoms-and-prevention-of-cancer-in-menopause-the-value-of-vulvar-exam
#6
A R Palumbo, C Fasolino, G Santoro, V Gargano, M Rinaldi, B Arduino, M Belli, M Guida
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a constellation of symptoms, that may affect daily activities, sexuality, relationships, and quality of life [3]. Early recognition and effective treatment of VVA may enhance sexual health and the quality of life of women and their partners. Some vulvar conditions such as lichen sclerosus are more prevalent in the postmenopausal years...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27895887/symmetry-lasts-longer-than-random-but-only-for-brief-presentations
#7
Ruth Ogden, Alexis D J Makin, Letizia Palumbo, Marco Bertamini
Previous research has shown that explicit emotional content or physical image properties (e.g., luminance, size, and numerosity) alter subjective duration. Palumbo recently demonstrated that the presence or absence of abstract reflectional symmetry also influenced subjective duration. Here, we explored this phenomenon further by varying the type of symmetry (reflection or rotation) and the objective duration of stimulus presentation (less or more than 1 second). Experiment 1 used a verbal estimation task in which participants estimated the presentation duration of reflection, rotation symmetry, or random square-field patterns...
November 2016: I-Perception
https://www.readbyqxmd.com/read/27891552/enteric-glial-cells-are-susceptible-to-clostridium-difficile-toxin-b
#8
Katia Fettucciari, Pamela Ponsini, Davide Gioè, Lara Macchioni, Camilla Palumbo, Elisabetta Antonelli, Stefano Coaccioli, Vincenzo Villanacci, Lanfranco Corazzi, Pierfrancesco Marconi, Gabrio Bassotti
Clostridium difficile causes nosocomial/antibiotic-associated diarrhoea and pseudomembranous colitis. The major virulence factors are toxin A and toxin B (TcdB), which inactivate GTPases by monoglucosylation, leading to cytopathic (cytoskeleton alteration, cell rounding) and cytotoxic effects (cell-cycle arrest, apoptosis). C. difficile toxins breaching the intestinal epithelial barrier can act on underlying cells, enterocytes, colonocytes, and enteric neurons, as described in vitro and in vivo, but until now no data have been available on enteric glial cell (EGC) susceptibility...
November 28, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27886537/bioelectrochemical-approach-for-reductive-and-oxidative-dechlorination-of-chlorinated-aliphatic-hydrocarbons-cahs
#9
Agnese Lai, Federico Aulenta, Marina Mingazzini, Maria Teresa Palumbo, Marco Petrangeli Papini, Roberta Verdini, Mauro Majone
A sequential reductive-oxidative treatment was developed in this study in a continuous-flow bioelectrochemical reactor to address bioremediation of groundwater contaminated by trichloroethene (TCE) and less-chlorinated but still harmful intermediates, such as vinyl chloride. In order to optimize the anodic compartment, whereby the oxygen-driven microbial oxidation of TCE-daughter products occurs, abiotic batch experiments were performed with various anode materials poised at +1.20 V vs. SHE (i.e., graphite rods and titanium mesh anode coated with mixed metal oxides (MMO)) and setups (i...
November 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/27885857/dosimetric-trade-offs-in-breast-treatment-with-vmat-technique
#10
Antonella Fogliata, Jan Seppälä, Giacomo Reggiori, Francesca Lobefalo, Valentina Palumbo, Fiorenza De Rose, Davide Franceschini, Marta Scorsetti, Luca Cozzi
OBJECTIVES: Breast planning with volumetric modulated arc therapy (VMAT) has been explored, especially for left sided breast treatments, with the primary intent of lowering the heart dose and improving target dose homogeneity. As a trade-off, larger healthy tissue volumes would receive low dose levels, with the potential risk of increasing late toxicities and secondary cancer induction, although no clinical data are today available to confirm the risk level. Scope of this work is to explore the dosimetric trade-offs using two different VMAT planning...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27884103/amplimethprofiler-a-pipeline-for-the-analysis-of-cpg-methylation-profiles-of-targeted-deep-bisulfite-sequenced-amplicons
#11
Giovanni Scala, Ornella Affinito, Domenico Palumbo, Ermanno Florio, Antonella Monticelli, Gennaro Miele, Lorenzo Chiariotti, Sergio Cocozza
BACKGROUND: CpG sites in an individual molecule may exist in a binary state (methylated or unmethylated) and each individual DNA molecule, containing a certain number of CpGs, is a combination of these states defining an epihaplotype. Classic quantification based approaches to study DNA methylation are intrinsically unable to fully represent the complexity of the underlying methylation substrate. Epihaplotype based approaches, on the other hand, allow methylation profiles of cell populations to be studied at the single molecule level...
November 25, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27879641/hydrogen-induced-abrupt-structural-expansion-at-high-temperatures-of-a-ni32nb28zr30cu10-membrane-for-h%C3%A2-purification
#12
Oriele Palumbo, Francesco Trequattrini, Madhura Hulyalkar, Suchismita Sarker, Narendra Pal, Dhanesh Chandra, Ted Flanagan, Michael Dolan, Annalisa Paolone
Ni-Nb-Zr amorphous membranes, prepared by melt-spinning, show great potential for replacing crystalline Pd-based materials in the field of hydrogen purification to an ultrapure grade (>99.999%). In this study, we investigate the temperature evolution of the structure of an amorphous ribbon with the composition Ni32Nb28Zr30Cu10 (expressed in atom %) by means of XRD and DTA measurements. An abrupt structural expansion is induced between 240 and 300 °C by hydrogenation. This structural modification deeply modifies the hydrogen sorption properties of the membrane, which indeed shows a strong reduction of the hydrogen capacity above 270 °C...
November 21, 2016: Membranes
https://www.readbyqxmd.com/read/27870386/hyaluronic-acid-derivative-with-improved-versatility-for-processing-and-biological-functionalization
#13
Fabio S Palumbo, Stefano Agnello, Calogero Fiorica, Giovanna Pitarresi, Roberto Puleio, Anna Tamburello, Ruggero Loria, Gaetano Giammona
No abstract text is available yet for this article.
November 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27869726/highly-sensitive-and-practical-detection-of-plant-viruses-via-electrical-impedance-of-droplets-on-textured-silicon-based-devices
#14
Marianna Ambrico, Paolo Francesco Ambrico, Angelantonio Minafra, Angelo De Stradis, Danilo Vona, Stefania R Cicco, Fabio Palumbo, Pietro Favia, Teresa Ligonzo
Early diagnosis of plant virus infections before the disease symptoms appearance may represent a significant benefit in limiting disease spread by a prompt application of appropriate containment steps. We propose a label-free procedure applied on a device structure where the electrical signal transduction is evaluated via impedance spectroscopy techniques. The device consists of a droplet suspension embedding two representative purified plant viruses i.e., Tomato mosaic virus and Turnip yellow mosaic virus, put in contact with a highly hydrophobic plasma textured silicon surface...
November 18, 2016: Sensors
https://www.readbyqxmd.com/read/27867343/park2-microduplication-clinical-and-molecular-characterization-of-a-further-case-and-review-of-the-literature
#15
Orazio Palumbo, Pietro Palumbo, Maria P Leone, Raffaella Stallone, Teresa Palladino, Marcella Vendemiale, Stefano Palladino, Francesco Papadia, Massimo Carella, Rira Fischetto
We report on a patient with psychomotor deficits, language delay, dyspraxia, skeletal anomalies, and facial dysmorphisms (hirsutism, right palpebral ptosis, a bulbous nasal tip with enlarged and anteverted nares, and a mild prominent antihelix stem). Using high-resolution SNP array analysis, we identified a 0.49-Mb microduplication in chromosome 6q26 inherited from the mother involving the PARK2 gene: arr[hg19] 6q26(162,672,821-163,163,143)×3 mat. To the best of our knowledge, this is the third patient to date described in whom a 6q26 microduplication encompassing only the PARK2 gene has been reported in medical literature...
October 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27864693/synthesis-and-biological-evaluation-of-a-novel-amadori-compound
#16
Giovanni N Roviello, Roberta Iannitti, Valentina Roviello, Rosanna Palumbo, Hayarpi Simonyan, Caterina Vicidomini
Here, we report the synthesis, purification, ESI MS and NMR characterization, as well as the SEM analysis of a fructosyl thiophenyl-substituted triazolyl-thione L-alanine (denominated Fru-L-TTA). This novel fructosyl derivative was obtained by solution synthesis using the Amadori reaction, in analogy to other natural fructosyl-amino acids, and fully characterized. In particular, we report an accurate NMR/MS/SEM characterization of Fru-L-TTA alongside some biological properties, and investigated to compare the properties of the artificial derivative of this work with the natural counterparts...
November 18, 2016: Amino Acids
https://www.readbyqxmd.com/read/27864218/second-primary-malignancies-in-multiple-myeloma-an-overview-and-imwg-consensus
#17
REVIEW
P Musto, K C Anderson, M Attal, P G Richardson, A Badros, J Hou, R Comenzo, J Du, B G M Durie, J San Miguel, H Einsele, W M Chen, L Garderet, G Pietrantuono, J Hillengass, R A Kyle, P Moreau, J J Lahuerta, O Landgren, H Ludwig, A Larocca, A Mahindra, M Cavo, A Mazumder, P L McCarthy, A Nouel, S V Rajkumar, A Reiman, E R Serra, O Sezer, E Terpos, I Turesson, S Usmani, B M Weiss, A Palumbo
BACKGROUND: Therapeutic advancements following the introduction of autologous stem cell transplantation and 'novel' agents have significantly improved clinical outcomes for patients with multiple myeloma (MM). Increased life expectancy, however, has led to renewed concerns about the long-term risk of second primary malignancies (SPMs). This review outlines the most up-to-date knowledge of possible host-, disease-, and treatment-related risk factors for the development of SPMs in patients with MM, and provides practical recommendations to assist physicians...
November 17, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27862891/effects-of-foliar-and-systemic-insecticides-on-whitefly-transmission-and-incidence-of-cucurbit-yellow-stunting-disorder-virus
#18
S J Castle, John Palumbo, Paul Merten, Charles Cowden, Nilima Prabhaker
BACKGROUND: Cucurbit yellow stunting disorder virus (CYSDV) is a cosmopolitan viral disease transmitted by Bemisia tabaci that infects cucurbit crops. Cantaloupe production in the southwestern U.S. has been confronted by epidemics of CYSDV since 2006 when it was first identified in Arizona and California. As a phloem-limited virus that is vectored in a semi-persistent manner by B. tabaci, CYSDV has transmission characteristics that may be suppressed by select insecticide applications...
November 11, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27849862/220-characterization-of-inhaled-nitric-oxide-utilization-in-a-pediatric-intensive-care-unit
#19
Kathryn Palumbo, Katherine Biagas, Erika Berman-Rosensweig
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846343/temperature-profile-of-ex-vivo-organs-during-radio-frequency-thermal-ablation-by-fiber-bragg-gratings
#20
Giovanna Palumbo, Agostino Iadicicco, Daniele Tosi, Paolo Verze, Nicola Carlomagno, Vincenzo Tammaro, Juliet Ippolito, Stefania Campopiano
No abstract text is available yet for this article.
November 1, 2016: Journal of Biomedical Optics
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