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Psp mycobacterium

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https://www.readbyqxmd.com/read/29488183/variations-on-a-theme-evolution-of-the-phage-shock-protein-system-in-actinobacteria
#1
Janani Ravi, Vivek Anantharaman, L Aravind, Maria Laura Gennaro
The phage shock protein (Psp) stress-response system protects bacteria from envelope stress through a cascade of interactions with other proteins and membrane lipids to stabilize the cell membrane. A key component of this multi-gene system is PspA, an effector protein that is found in diverse bacterial phyla, archaea, cyanobacteria, and chloroplasts. Other members of the Psp system include the cognate partners of PspA that are part of known operons: pspF||pspABC in Proteobacteria, liaIHGFSR in Firmicutes, and clgRpspAMN in Actinobacteria...
February 27, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29140686/the-regulatory-mechanism-of-mycobacterium-tuberculosis-phosphoserine-phosphatase-serb2
#2
Gregory A Grant
Almost all organisms contain the same biosynthetic pathway for the synthesis of l-serine from the glycolytic intermediate, D-3-phosphoglycerate. However, regulation of this pathway varies from organism to organism. Many organisms control the activity of the first enzyme in the pathway, D-3-phosphoglyerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme. The last enzyme in the pathway, phosphoserine phosphatase (PSP) has also been reported to be inhibited by l-serine...
November 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/27002134/rv2744c-is-a-pspa-ortholog-that-regulates-lipid-droplet-homeostasis-and-nonreplicating-persistence-in-mycobacterium-tuberculosis
#3
Richard M Armstrong, Katherine L Adams, Joseph E Zilisch, Daniel J Bretl, Hiromi Sato, David M Anderson, Thomas C Zahrt
UNLABELLED: Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a significant cause of morbidity and mortality worldwide, despite the availability of a live attenuated vaccine and anti-TB antibiotics. The vast majority of individuals infected with M. tuberculosis develop an asymptomatic latent infection in which the bacterium survives within host-generated granulomatous lesions in a physiologically altered metabolic state of nonreplicating persistence. The granuloma represents an adverse environment, as M...
June 1, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/25037224/high-throughput-screen-identifies-small-molecule-inhibitors-specific-for-mycobacterium-tuberculosis-phosphoserine-phosphatase
#4
Garima Arora, Prabhakar Tiwari, Rahul Shubhra Mandal, Arpit Gupta, Deepak Sharma, Sudipto Saha, Ramandeep Singh
The emergence of drug-resistant strains of Mycobacterium tuberculosis makes identification and validation of newer drug targets a global priority. Phosphoserine phosphatase (PSP), a key essential metabolic enzyme involved in conversion of O-phospho-l-serine to l-serine, was characterized in this study. The M. tuberculosis genome harbors all enzymes involved in l-serine biosynthesis including two PSP homologs: Rv0505c (SerB1) and Rv3042c (SerB2). In the present study, we have biochemically characterized SerB2 enzyme and developed malachite green-based high throughput assay system to identify SerB2 inhibitors...
September 5, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/17158455/the-mycobacterium-tuberculosis-cell-surface-glycoprotein-apa-as-a-potential-adhesin-to-colonize-target-cells-via-the-innate-immune-system-pulmonary-c-type-lectin-surfactant-protein-a
#5
Aude Ragas, Lucie Roussel, Germain Puzo, Michel Rivière
Tuberculosis is still a major health problem, and understanding the mechanism by which Mycobacterium tuberculosis (Mtb) invades and colonizes its host target cells remains an important issue for the control of infection. The innate immune system C-type lectins (C-TLs), including the human pulmonary surfactant protein A (PSP-A), have been recently identified as determinant players in the early recognition of the invading pathogen and in mounting the host defense response. Although the antigenic lipoglycan mannosylated lipoarabinomannan is currently considered to be the major C-TL target on the mycobacterial surface, the recognition by some C-TLs of the only mycobacterial species composing the "Mtb complex" indicates that mannosylated lipoarabinomannan cannot account alone for this specificity...
February 23, 2007: Journal of Biological Chemistry
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