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https://www.readbyqxmd.com/read/28071654/responsiveness-of-endoscopic-indices-of-disease-activity-for-crohn-s-disease
#1
Reena Khanna, GuangYong Zou, Larry Stitt, Brian G Feagan, William J Sandborn, Paul Rutgeerts, John W D McDonald, Elena Dubcenco, Ronald Fogel, Remo Panaccione, Vipul Jairath, Sigrid Nelson, Lisa M Shackelton, Bidan Huang, Qian Zhou, Anne M Robinson, Barrett G Levesque, Geert D'Haens
OBJECTIVES: The Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however neither instrument is fully validated. We evaluated the responsiveness to change of the SES-CD and CDEIS using data from a trial of adalimumab, a drug therapy of known efficacy. METHODS: Paired video recordings (N=112) of colonoscopies (baseline and week 8-12) obtained from patients with CD who participated in a trial of adalimumab therapy were reviewed in random order, in duplicate, by four central readers (56 pairs of videos by 2 groups of readers)...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28052350/eses-software-for-eulerian-solvent-excluded-surface
#2
Beibei Liu, Bao Wang, Rundong Zhao, Yiying Tong, Guo-Wei Wei
Solvent excluded surface (SES) is one of the most popular surface definitions in biophysics and molecular biology. In addition to its usage in biomolecular visualization, it has been widely used in implicit solvent models, in which SES is usually immersed in a Cartesian mesh. Therefore, it is important to construct SESs in the Eulerian representation for biophysical modeling and computation. This work describes a software package called Eulerian solvent excluded surface (ESES) for the generation of accurate SESs in Cartesian grids...
January 4, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28005937/impact-of-socioeconomic-inequality-on-access-adherence-and-outcomes-of-antiretroviral-treatment-services-for-people-living-with-hiv-aids-in-vietnam
#3
Bach Xuan Tran, Jongnam Hwang, Long Hoang Nguyen, Anh Tuan Nguyen, Noah Reed Knowlton Latkin, Ngoc Kim Tran, Vu Thi Minh Thuc, Huong Lan Thi Nguyen, Huong Thu Thi Phan, Huong Thi Le, Tho Dinh Tran, Carl A Latkin
BACKGROUND: Ensuring an equal benefit across different patient groups is necessary while scaling up free-of-charge antiretroviral treatment (ART) services. This study aimed to measure the disparity in access, adherence, and outcomes of ART in Vietnam and the effects of socioeconomic status (SES) characteristics on the levels of inequality. METHODS: A cross-sectional study was conducted in 1133 PLWH in Vietnam. ART access, adherence, and treatment outcomes were self-reported using a structured questionnaire...
2016: PloS One
https://www.readbyqxmd.com/read/27951629/breast-density-and-risk-of-breast-cancer-in-asian-women-a-meta-analysis-of-observational-studies
#4
REVIEW
Jong-Myon Bae, Eun Hee Kim
OBJECTIVES: The established theory that breast density is an independent predictor of breast cancer risk is based on studies targeting white women in the West. More Asian women than Western women have dense breasts, but the incidence of breast cancer is lower among Asian women. This meta-analysis investigated the association between breast density in mammography and breast cancer risk in Asian women. METHODS: PubMed and Scopus were searched, and the final date of publication was set as December 31, 2015...
November 2016: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
https://www.readbyqxmd.com/read/27935048/height-related-scaling-of-phloem-anatomy-and-the-evolution-of-sieve-element-end-wall-types-in-woody-plants
#5
Johannes Liesche, Marcelo R Pace, Qiyu Xu, Yongqing Li, Shaolin Chen
In the sieve elements (SEs) of the phloem, carbohydrates are transported throughout the whole plant from their site of production to sites of consumption or storage. SE structure, especially of the pore-rich end walls, has a direct effect on translocation efficiency. Differences in pore size and other features were interpreted as an evolutionary trend towards reduced hydraulic resistance. However, this has never been confirmed. Anatomical data of 447 species of woody angiosperms and gymnosperms were used for a phylogenetic analysis of end wall types, calculation of hydraulic resistance and correlation analysis with morphological and physiological variables...
December 9, 2016: New Phytologist
https://www.readbyqxmd.com/read/27932053/green-and-lean-is-neighborhood-park-and-playground-availability-associated-with-youth-obesity-variations-by-gender-socioeconomic-status-and-race-ethnicity
#6
S Morgan Hughey, Andrew T Kaczynski, Stephanie Child, Justin B Moore, Dwayne Porter, James Hibbert
Parks and park features are important for promoting physical activity and healthy weight, especially for low-income and racial/ethnic minority youth who have disproportionately high obesity rates. This study 1) examined associations between neighborhood park and playground availability and youth obesity, and 2) assessed whether these associations were moderated by youth race/ethnicity and socioeconomic status (SES). In 2013, objectively measured height and weight were collected for all 3rd-5th grade youth (n=13...
December 6, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27923037/adherence-to-colorectal-cancer-screening-four-rounds-of-faecal-immunochemical-test-based-screening
#7
Manon van der Vlugt, Esmée J Grobbee, Patrick Mm Bossuyt, Evelien Bongers, Wolfert Spijker, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Marie-Louise Essink-Bot, Manon C W Spaander, Evelien Dekker
BACKGROUND: The effectiveness of faecal immunochemical test (FIT)-based screening programs is highly dependent on consistent participation over multiple rounds. We evaluated adherence to FIT screening over four rounds and aimed to identify determinants of participation behaviour. METHODS: A total of 23 339 randomly selected asymptomatic persons aged 50-74 years were invited for biennial FIT-based colorectal cancer screening between 2006 and 2014. All were invited for every consecutive round, except for those who had moved out of the area, passed the upper age limit, or had tested positive in a previous screening round...
January 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27855292/the-current-prevalence-and-regional-disparities-in-general-and-central-obesity-among-children-and-adolescents-in-shandong-china
#8
Ying-Xiu Zhang, Zhao-Xia Wang, Jin-Shan Zhao, Zun-Hua Chu
BACKGROUND: Childhood obesity has increased dramatically during the past decades, both in developing and developed countries. The present study examined the prevalence and regional disparities in general and central obesity among children and adolescents in Shandong, China. METHODS: A total of 30,459 students (15,249 boys and 15,210 girls) aged 7-18years participated in the study. Height, weight and waist circumference (WC) of all subjects were measured, body mass index (BMI) and waist-to-height ratio (WHtR) were calculated...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27845549/assets-as-a-socioeconomic-status-index-categorical-principal-components-analysis-vs-latent-class-analysis
#9
Majid Sartipi, Saharnaz Nedjat, Mohammad Ali Mansournia, Vali Baigi, Akbar Fotouhi
BACKGROUND: Some variables like Socioeconomic Status (SES) cannot be directly measured, instead, so-called 'latent variables' are measured indirectly through calculating tangible items. There are different methods for measuring latent variables such as data reduction methods e.g. Principal Components Analysis (PCA) and Latent Class Analysis (LCA). OBJECTIVES: The purpose of our study was to measure assets index- as a representative of SES- through two methods of Non-Linear PCA (NLPCA) and LCA, and to compare them for choosing the most appropriate model...
November 2016: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/27801971/twenty-five-year-survival-for-aboriginal-and-caucasian-children-with-congenital-heart-defects-in-western-australia-1980-to-2010
#10
Wendy N Nembhard, Jenny Bourke, Helen Leonard, Luke Eckersley, Jingyun Li, Carol Bower
BACKGROUND: Australian Aboriginal children have increased infant and childhood mortality compared with Caucasian children, but their mortality related to congenital heart defects (CHDs) throughout life is unknown. METHODS: We conducted a retrospective cohort study using data on 8,110 live born, singleton infants with CHDs born January 1980 to December 2010 from the Western Australian Register of Developmental Anomalies. Vital status was determined from death and medical records...
December 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27761650/examining-the-socioeconomic-effects-on-third-molar-maturation-in-a-portuguese-sample-of-children-adolescents-and-young-adults
#11
J L Carneiro, I M Caldas, A Afonso, H F V Cardoso
INTRODUCTION: The impact of socioeconomic status (SES) on tooth mineralization has seldom been evaluated. This is important because SES can be used as a proxy for quantifying factors in the environmental that can impact mineralization but that can be difficult to measure directly, such as nutrition. OBJECTIVE: The objective of this study was to examine the effects of SES on third molar mineralization, using a sample of children, adolescents and young adults from Porto, Portugal...
January 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27752298/using-principal-component-analysis-to-identify-priority-neighbourhoods-for-health-services-delivery-by-ranking-socioeconomic-status
#12
Christine Elizabeth Friesen, Patrick Seliske, Andrew Papadopoulos
Objectives. Socioeconomic status (SES) is a comprehensive indicator of health status and is useful in area-level health research and informing public health resource allocation. Principal component analysis (PCA) is a useful tool for developing SES indices to identify area-level disparities in SES within communities. While SES research in Canada has relied on census data, the voluntary nature of the 2011 National Household Survey challenges the validity of its data, especially income variables. This study sought to determine the appropriateness of replacing census income information with tax filer data in neighbourhood SES index development...
2016: Online Journal of Public Health Informatics
https://www.readbyqxmd.com/read/27744234/examining-the-effect-of-childhood-trauma-on-psychological-distress-risk-of-violence-and-engagement-in-forensic-mental-health
#13
Marlene Macinnes, Gary Macpherson, Jessica Austin, Matthias Schwannauer
Previous research has found an association between childhood trauma and insecure attachment and psychological distress, risk of violence and engagement in therapy. The aim of this study was to investigate the relationships between these factors in a forensic population. Sixty-four participants from three secure psychiatric hospitals completed the Childhood Trauma Questionnaire (CTQ), the Relationship Scales Questionnaire (RSQ) and the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM). Overall scores from participants' Historical Clinical Risk Management Violence Risk Assessment Scheme, (HCR-20) were calculated...
December 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27730258/variability-of-control-data-and-relevance-of-observed-group-differences-in-five-oral-toxicity-studies-with-genetically-modified-maize-mon810-in-rats
#14
Kerstin Schmidt, Jörg Schmidtke, Paul Schmidt, Christian Kohl, Ralf Wilhelm, Joachim Schiemann, Hilko van der Voet, Pablo Steinberg
The data of four 90-day feeding trials and a 1-year feeding trial with the genetically modified (GM) maize MON810 in Wistar Han RCC rats performed in the frame of EU-funded project GRACE were analysed. Firstly, the data obtained from the groups having been fed the non-GM maize diets were combined to establish a historical control data set for Wistar Han RCC rats at the animal housing facility (Slovak Medical University, Bratislava, Slovakia). The variability of all parameters is described, and the reference values and ranges have been derived...
October 11, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27687737/nutritional-risk-factors-and-status-of-serum-25-oh-d-levels-in-patients-with-breast-cancer-a-case-control-study-in-india
#15
Nighat Y Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Vineet Kumar Kamal, Ravinder Mohan Pandey
To study the nutritional risk factors and status of serum 25(OH)D levels in patients with breast cancer. A total of 100 women (cases) with confirmed breast cancer (BC) matched with equal number of healthy females (controls) of similar age and socioeconomic status (SES) were included in study. Controls included were nonbreast cancer patients who accompanied the patients to a tertiary care hospital. All the subjects (cases and controls) were administered a questionnaires to collect data on socioeconomic status, dietary pattern and the frequency of food consumption using a validated food frequency questionnaire...
September 26, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27686450/multilevel-modelling-of-somatotype-components-the-portuguese-sibling-study-on-growth-fitness-lifestyle-and-health
#16
Sara Pereira, Peter T Katzmarzyk, Thayse Natacha Gomes, Michele Souza, Raquel N Chaves, Fernanda K Dos Santos, Daniel Santos, Donald Hedeker, José A R Maia
BACKGROUND: Somatotype is a complex trait influenced by different genetic and environmental factors as well as by other covariates whose effects are still unclear. AIM: To (1) estimate siblingś resemblance in their general somatotype; (2) identify sib-pair (brother-brother (BB), sister-sister (SS), brother-sister (BS)) similarities in individual somatotype components; (3) examine the degree to which between and within variances differ among sib-ships; (4) investigate the effects of physical activity (PA) and family socioeconomic status (SES) on these relationships...
September 29, 2016: Annals of Human Biology
https://www.readbyqxmd.com/read/27668279/bias-with-respect-to-socioeconomic-status-a-closer-look-at-zip-code-matching-in-a-pneumococcal-vaccine-effectiveness-study
#17
Ruth Link-Gelles, Daniel Westreich, Allison E Aiello, Nong Shang, David J Weber, Corinne Holtzman, Karen Scherzinger, Arthur Reingold, William Schaffner, Lee H Harrison, Jennifer B Rosen, Susan Petit, Monica Farley, Ann Thomas, Jeffrey Eason, Christine Wigen, Meghan Barnes, Ola Thomas, Shelley Zansky, Bernard Beall, Cynthia G Whitney, Matthew R Moore
In 2010, 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the US for prevention of invasive pneumococcal disease in children. Individual-level socioeconomic status (SES) is a potential confounder of the estimated effectiveness of PCV13 and is often controlled for in observational studies using zip code as a proxy. We assessed the utility of zip code matching for control of SES in a post-licensure evaluation of the effectiveness of PCV13 (calculated as [1-matched odds ratio]*100). We used a directed acyclic graph to identify subsets of confounders and collected SES variables from birth certificates, geo-coding, a parent interview, and follow-up with medical providers...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/27664009/offspring-socioeconomic-status-and-parent-mortality-within-a-historical-population
#18
Zachary Zimmer, Heidi A Hanson, Ken R Smith
Considering a network approach to health determinants, we test the hypothesis that benefits of high socioeconomic status (SES) may be transmitted up the generational ladder from offspring to parents. Studies that examine own SES and own health outcomes, or SES of parents and outcomes of young or adolescent children, are common. Those that investigate SES of offspring and their association with parental health are rare. Employing data from a historical population of individuals extracted from a comprehensive population database that links demographic and vital records across generations, this study tests the hypothesis that higher offspring SES associates with lower parental mortality after controlling for parental SES...
October 2016: Demography
https://www.readbyqxmd.com/read/27599973/comparison-of-three-magnetic-resonance-enterography-indices-for-grading-activity-in-crohn-s-disease
#19
Jordi Rimola, Almudena Alvarez-Cofiño, Tamara Pérez-Jeldres, Carmen Ayuso, Ignacio Alfaro, Sonia Rodríguez, Elena Ricart, Ingrid Ordás, Julián Panés
BACKGROUND: Magnetic resonance enterography (MRE) is an accurate examination for assessing activity in Crohn's disease (CD). Various MRE indices have been developed for that purpose, but have not been directly compared. The aim of the study was to compare the diagnostic accuracy of three MRE indices for detecting and grading disease activity in CD, using endoscopy as gold standard. METHODS: MRE and ileocolonoscopies performed within 1 month in 43 patients with CD were analyzed...
September 6, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27540957/health-disparities-and-impact-on-outcomes-in-children-with-primary-central-nervous-system-solid-tumors
#20
Mary T Austin, Emma Hamilton, Denna Zebda, Hoang Nguyen, Jan M Eberth, Yuchia Chang, Linda S Elting, David I Sandberg
OBJECTIVE Health disparities in access to care, early detection, and survival exist among adult patients with cancer. However, there have been few reports assessing how health disparities impact pediatric patients with malignancies. The objective in this study was to examine the impact of racial/ethnic and social factors on disease presentation and outcome for children with primary CNS solid tumors. METHODS The authors examined all children (age ≤ 18 years) in whom CNS solid tumors were diagnosed and who were enrolled in the Texas Cancer Registry between 1995 and 2009 (n = 2421)...
August 19, 2016: Journal of Neurosurgery. Pediatrics
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