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Leishmaniosis

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https://www.readbyqxmd.com/read/28986939/leishmania-infection-in-rodents-in-greece
#1
Ιoannis Tsakmakidis, Katerina Angelopoulou, Chrysostomos I Dovas, Εmmanouil Dokianakis, Αndroniki Tamvakis, Isaia Symeonidou, Μaria Antoniou, Αnastasia Diakou
OBJECTIVE: To investigate the prevalence of Leishmania infection in rodents from various areas of Northern Greece. METHODS: 97 rodents (66 Mus musculus, 18 Rattus norvegicus and 12 R. rattus) were collected during pest control programs and examined by cytology (spleen and liver smears), serology (ELISA) and PCR (real-time and gel-based) for Leishmania. Date, environment, sex, existence of dogs in the close environment were recorded for each rodent. All cytological preparations were negative, whereas specific IgG were detected in 54...
October 6, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28979340/iranian-native-plants-on-treatment-of-cutaneous-leishmaniosis-a-narrative-review
#2
REVIEW
Elham Moghaddas, Ali Khamesipour, Mehdi Mohebali, Abdolmajid Fata
BACKGROUND: Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosin, and allopurinol. In this study, we explained about the native plant that grows in different regions of Iran and used as anti-leishmanial in Iran and even many other countries. METHODS: This narrative review covers all information about local herbal medicine in Iran that used in treatment of cutaneous leishmaniasis in all the worlds, published in local and international journals from 1996 to 2015 using various databases including PubMed, SID, Google Scholar, Scopus, and Science Direct...
July 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28929498/dog-skin-parasite-load-tlr-2-il-10-and-tnf-%C3%AE-expression-and-infectiousness
#3
D C M Pereira-Fonseca, F M Oliveira-Rovai, L A C Rodas, C A C Beloti, R B P Torrecilha, P K R K Ito, S V Avanço, R S Cipriano, Y T Utsunomiya, R M Hiramoto, L Calvo-Bado, O Courtenay, G F Machado, V M F Lima, C M Nunes
Visceral leishmaniosis is a zoonotic disease that is transmitted by Lutzomyia longipalpis sandflies. Dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. Type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF-α). In contrast, Type 2 immunity is predominantly humoral, associated with progression of the disease and mediated by anti-inflammatory cytokines such as interleukin 10 (IL-10)...
November 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28915996/alternative-strategy-for-visceral-leishmaniosis-control-hisak70-salmonella-choleraesuis-pulsed-dendritic-cells
#4
Gustavo Domínguez-Bernal, Abel Martínez-Rodrigo, Alicia Mas, M Mar Blanco, José A Orden, Ricardo De La Fuente, Javier Carrión
Here, we describe a novel approach that exploits an attenuated mutant of Salmonella enterica serovar Choleraesuis as carrier to deliver a plasmid encoding protein HisAK70. Subsequently, dendritic cells (DCs) were pulsed with this vaccine vector. The aim of this study was to evaluate the effectiveness of the prepared HisAK70-S. Choleraesuis-pulsed DCs (HisAK70-SAL DCs) against visceral leishmaniosis (VL). In our ex vivo model of infection, the prepared formulations could decrease parasite growth by up to 80% by augmenting the production of IL-12p40 and by reducing arginase activity (ARG)...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28895868/identification-of-novel-biomarkers-for-treatment-monitoring-in-canine-leishmaniosis-by-high-resolution-quantitative-proteomic-analysis
#5
Silvia Martinez-Subiela, Anita Horvatic, Damian Escribano, Luis Pardo-Marin, Meric Kocaturk, Vladimir Mrljak, Richard Burchmore, Jose J Ceron, Zeki Yilmaz
The objective of this study was to use the Tandem Mass Tag (TMT) isobaric label-based proteomic approach, in order to identify new potential biomarkers for the treatment monitoring of canine leishmaniosis that could not be identified by the use of gel-based techniques. For this purpose serum samples were obtained from 5 clinically diseased dogs before and one month after the treatment of canine leishmaniosis. The non-depleted serum samples were subjected to reduction, alkylation and trypsin digestion, and the resulting peptides were labeled using 6-plex TMT reagents...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28892427/norwegian-or-crusted-sarcoptic-mange-in-two-leishmanial-dogs
#6
Flora Kaltsogianni, Rania Farmaki, Alexander F Koutinas
Norwegian or crusted scabies (N/CS) is a rare skin disease with very few cases reported in the dog or the cat. Two adult, stray dogs were admitted in our clinic with a generalized, multifocal to diffuse and nonpruritic dermatitis that was characterized by severe crusting, scaling, and ulceration. In both instances, leishmaniosis and N/CS were diagnosed by immunofluorescent antibody test serology, lymph node cytology, and skin scrapings in which high numbers of Sarcoptes mites were found. The combination of miticidal and antileishmanial treatment, supported by topical treatment and nutritional support, resulted in the complete resolution of the skin lesions and spectacular improvement of the body condition in both cases...
September 11, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28807304/association-between-mast-cells-tissue-remodelation-and-parasite-burden-in-the-skin-of-dogs-with-visceral-leishmaniasis
#7
Jamille Mirelle de Oliveira Cardoso, Henrique Gama Ker, Rodrigo Dian de Oliveira Aguiar-Soares, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Bruno Mendes Roatt, Paula Melo de Abreu Vieira, Wendel Coura-Vital, Cláudia Martins Carneiro, Alexandre Barbosa Reis
Canine visceral leishmaniosis (CVL) is a zoonosis of major public health impact caused by organisms of the genus Leishmania which is transmitted to human and animals by phlebotomine sand flies. The skin is the first point of contact with Leishmania parasites for sandy fly vectors and it is considered an important reservoir compartment in infected dogs. The aim of this study was to determine the main histophatologic alterations in ear skin of dogs naturally infected by Leishmania infantum with different clinical status and different degrees of parasitism...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807297/cutaneous-leishmaniosis-in-naturally-infected-dogs-in-paran%C3%A3-brazil-and-the-epidemiological-implications-of-leishmania-viannia-braziliensis-detection-in-internal-organs-and-intact-skin
#8
Ellen de Souza Marquez, Edilene Alcântara de Castro, Luciene Biazono Nabut, Magda Clara Vieira da Costa-Ribeiro, Ludmilla Dela Coletta Troiano Araújo, Saloe Bispo Poubel, André Luiz Gonçalves, Mariza Fordellone Rosa Cruz, Ana Paula Millet Evangelista Dos Santos Trad, Rafael Andre Ferreira Dias, Italmar Teodorico Navarro, Vanete Thomaz-Soccol
Environmental changes have occurred over the years, altering the eco-epidemiological pattern of leishmaniosis in the State of Paraná, Brazil, involving the pillars of the cycle (parasite, vectors, reservoir, and environment) and their interaction. Much has been discussed about the dog's role as a reservoir of the Leishmania (Viannia) braziliensis Vianna, 1911 transmission cycle. However, this question remains unanswered. The purpose of this study was to investigate, using parasitological and molecular methods, different samples in eight naturally infected dogs from an endemic rural locality where only L...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28752261/leishmanicidal-effect-of-antiparasitic-photodynamic-therapy-appdt-on-infected-macrophages
#9
Susana de Oliveira, Evaristo João da Ordem Trahamane, Juliana Monteiro, Gustavo Pires Santos, Pedro Crugeira, Fernando Sampaio, Camila Oliveira, Manoel Barral Neto, Antônio Pinheiro
The aim of this study is to evaluate the effects of ApPDT (antiparasitic photodynamic therapy) on the interaction of Leishmania braziliensis with J774 macrophages, used as a photosensitizer, methylene blue associated with red laser. The tests are in triplicate and the samples divided into four groups: control, photosensitizer, laser, and ApPDT. The photosensitizer used was the methylene blue at concentration of 12.5 μg/mL. The parameters of the laser were λ = 660 nm, 40 mW, and 8.4 J/cm(2). Samples are analyzed by optical microscopy through the identification and counting of infected and uninfected macrophages, parasite load, infectivity, and infection index...
July 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28717956/retrospective-analysis-of-canine-vector-borne-diseases-cvbd-in-germany-with-emphasis-on-the-endemicity-and-risk-factors-of-leishmaniosis
#10
Majda Globokar Vrhovec, Nikola Pantchev, Klaus Failing, Christian Bauer, Nora Travers-Martin, Horst Zahner
No abstract text is available yet for this article.
July 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28705248/prevention-of-feline-leishmaniosis-with-an-imidacloprid-10-flumethrin-4-5-polymer-matrix-collar
#11
Emanuele Brianti, Luigi Falsone, Ettore Napoli, Gabriella Gaglio, Salvatore Giannetto, Maria Grazia Pennisi, Vito Priolo, Maria Stefania Latrofa, Viviana Domenica Tarallo, Fabrizio Solari Basano, Roberto Nazzari, Katrin Deuster, Matthias Pollmeier, Laura Gulotta, Vito Colella, Filipe Dantas-Torres, Gioia Capelli, Domenico Otranto
BACKGROUND: Leishmaniosis caused by Leishmania infantum is one of the most important vector-borne diseases affecting animals and humans worldwide. Dogs are considered main reservoirs of the zoonotic forms, though in the last years the role of cats as reservoirs has been increasingly investigated. Feline leishmaniosis (FeL) occurs in endemic areas and no specific preventive measures have been investigated so far. In this study the efficacy of a 10% imidacloprid/4.5% flumethrin polymer matrix collar, licensed for tick and flea prevention, has been assessed against FeL in a longitudinal study on 204 privately owned cats from the Aeolian islands (Sicily), an area highly endemic for the disease...
July 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28689776/diagnostic-challenges-in-the-era-of-canine-leishmania-infantum-vaccines
#12
REVIEW
Laia Solano-Gallego, Luís Cardoso, Maria Grazia Pennisi, Christine Petersen, Patrick Bourdeau, Gaetano Oliva, Guadalupe Miró, Lluís Ferrer, Gad Baneth
The diagnosis of canine leishmaniosis (CanL) is complex due to its variable clinical manifestations and laboratory findings. The availability of vaccines to prevent CanL has increased the complexity of diagnosis, as serological tests may not distinguish between naturally infected and vaccinated dogs. Current practices of prevaccination screening are not sufficiently sensitive to detect subclinically infected dogs, resulting in the vaccination of infected animals, which may lead to disease in vaccinated dogs that are also infectious to sand flies...
September 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28682767/in-vitro-effects-of-purine-and-pyrimidine-analogues-on-leishmania-donovani-and-leishmania-infantum-promastigotes-and-intracellular-amastigotes
#13
Samira Azzouz, Philippe Lawton
Inhibition of parasite metabolic pathways is a rationale for new chemotherapeutic strategies. The pyrimidine and purine salvage pathways are thus targets against Leishmania donovani and L. infantum, causative agents of visceral human leishmaniasis and canine leishmaniosis. The antiproliferative effect of the pyrimidine analogues Cytarabine and 5-fluorouracil and of the purine analogues Azathioprine and 6-mercaptopurine was evaluated in vitro on the promastigote and the intracellular amastigote stages of the parasite...
September 26, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28606325/quantification-of-anti-leishmania-antibodies-in-saliva-of-dogs
#14
Ana Cantos-Barreda, Damián Escribano, Luis J Bernal, José J Cerón, Silvia Martínez-Subiela
Detection of serum anti-Leishmania antibodies by quantitative or qualitative techniques has been the most used method to diagnose Canine Leishmaniosis (CanL). Nevertheless, saliva may represent an alternative to blood because it is easy to collect, painless and non-invasive in comparison with serum. In this study, two time-resolved immunofluorometric assays (TR-IFMAs) for quantification of anti-Leishmania IgG2 and IgA antibodies in saliva were developed and validated and their ability to distinguish Leishmania-seronegative from seropositive dogs was evaluated...
August 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28601528/novel-areas-for-prevention-and-control-of-canine-leishmaniosis
#15
REVIEW
Guadalupe Miró, Christine Petersen, Luís Cardoso, Patrick Bourdeau, Gad Baneth, Laia Solano-Gallego, Maria Grazia Pennisi, Lluís Ferrer, Gaetano Oliva
There have been multiple recent advances regarding tools for the control and prevention of canine leishmaniosis (CanL), including new preventative vaccines. In this review, these advances are evaluated based on control targets, including vector and parasite. Leishvet recommendations are provided for control practices based on the dog's risk of infection. New topical insecticide formulations have proven to be effective in preventing sand fly bites, and subsequently infection. Parasite control occurs through chemotherapeutic or immunologic means, which decrease or prevent transmission to other animals, including humans...
September 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28534448/the-use-of-escherichia-coli-total-antigens-as-a-complementary-approach-to-address-seropositivity-to-leishmania-antigens-in-canine-leishmaniosis
#16
Carla Lima, João Rodrigo Mesquita, Hugo Brancal, Thomas Vahlenkamp, Ana Rafaela Teixeira, Luís Cardoso, Célia Amorim, Nuno Santarém, Anabela Cordeiro DA Silva
Canine leishmaniosis (CanL) is a major veterinary concern and a public health issue. Serological data are essential for disease management. Several antigens used in serological assays have specificity related problems preventing relevant seropositivity values establishment. Herein we report significant seropositivity level disparity in a study cohort with 384 dogs from eight countries, for antigens traditionally used in CanL - soluble promastigote Leishmania antigens (SPLA) and K39 recombinant protein (rK39): 43·8 and 2·9% for SPLA and rK39, respectively...
May 23, 2017: Parasitology
https://www.readbyqxmd.com/read/28528469/multiple-sclerosis-treatment-with-fingolimod-profile-of-non-cardiologic-adverse-events
#17
REVIEW
Yara Dadalti Fragoso
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. The drug is safe and effective, and its first hours of use are associated with related to S1P receptors in the heart...
May 20, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28495197/randomized-allopurinol-controlled-trial-of-the-effects-of-dietary-nucleotides-and-active-hexose-correlated-compound-in-the-treatment-of-canine-leishmaniosis
#18
Sergi Segarra, Guadalupe Miró, Ana Montoya, Luis Pardo-Marín, Noemí Boqué, Lluis Ferrer, José Cerón
First-line treatment for canine leishmaniosis (CanL) is N-methylglucamine antimoniate (MGA) combined with allopurinol. However, in some dogs allopurinol may induce hyperxanthinuria leading to urolithiasis. Moreover, allopurinol resistance has recently been described in Leishmania infantum isolates from treated dogs with a relapse of the disease. Alternative treatments are thus needed. Since the type of host immune response strongly influences CanL progression and prognosis, dogs could benefit from treatments targeted at modulating such response, such as nucleotides and active hexose correlated compound (AHCC)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28446214/epidemiological-role-of-dogs-since-the-human-leishmaniosis-outbreak-in-madrid
#19
Guadalupe Miró, Aurora Müller, Ana Montoya, Rocía Checa, Valentina Marino, Eloy Marino, Fernando Fuster, Cristina Escacena, Miguel Angel Descalzo, Rosa Gálvez
BACKGROUND: Canine leishmaniosis (CanL) has been in the spotlight since the 2009 outbreak of human leishmaniosis in Madrid. In the framework of the Leishmaniosis Surveillance Programme set up in Madrid, this study examines Leishmania-specific seroprevalences in stray dogs for the outbreak area and rest of the Madrid region over the period spanning from the outbreak to the present (2009-2016). These data are of interest because stray dogs could be sentinels for disease surveillance in endemic areas...
April 26, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28424022/analytical-validation-of-an-automated-assay-for-ferric-reducing-ability-of-plasma-in-dog-serum
#20
Camila Peres Rubio, Silvia Martinez-Subiela, Josefa Hernández-Ruiz, Asta Tvarijonaviciute, José Joaquín Ceron
We performed analytical validation of an automated ferric-reducing ability of plasma (FRAP) assay in the serum of dogs. Intra- and interassay precision, accuracy, detection limit, and effects of hemolysis and lipemia were evaluated. Intra- and interassay coefficients of variation were <1% and <13%, respectively. The assay showed a high correlation with a FRAP assay described previously, and results were linear when serial sample dilutions were tested. The detection limit was lower than the values observed in sera from healthy dogs; decreased serum FRAP was found in dogs with leishmaniosis...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
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