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Leishmaniosis

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https://www.readbyqxmd.com/read/27895289/management-prevention-and-treatment-of-canine-leishmaniosis-in-north-eastern-spain-an-online-questionnaire-based-survey-in-the-province-of-girona-with-special-emphasis-on-new-preventive-methods-canileish-vaccine-and-domperidone
#1
S Lladró, A Picado, C Ballart, M Portús, M Gállego
Knowledge of how canine leishmaniosis (CanL) is being managed clinically and its epidemiology is very important, since dogs are the main reservoir of human leishmaniosis. This study reports the results obtained through a questionnaire-based survey of veterinary practitioners in Girona province, a recognised, but non-documented endemic area in north-eastern Spain. The primary objective was to obtain data on the clinical management of CanL, focusing particularly on new preventive methods and therapeutic tools...
November 28, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27892869/serum-c-reactive-protein-and-ferritin-concentrations-in-dogs-undergoing-leishmaniosis-treatment
#2
Silvia Martinez-Subiela, Luis Pardo-Marín, Fernando Tecles, Gad Baneth, Jose J Cerón
Monitoring of selected serum acute phase proteins like C-reactive protein (CRP) and ferritin could be useful for evaluation of the response to treatment in both naturally-occurring and experimentally-induced leishmaniosis. However studies until date have only been focused on dogs with an adequate response to the treatment and there is a lack of knowledge about the possible associations between the CRP and ferritin and the different clinicopathological conditions that can appear after treatment. Thus, the main objective of this retrospective study was to evaluate and compare the serum concentration of CRP and ferritin between three possible situations that dogs which undergo leishmaniosis treatment could have: responsive with total recovery, responsive with only clinical recovery but persistent abnormalities in biochemical analytes, and unresponsive with clinical and biochemical changes...
September 9, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27865270/serum-apolipoprotein-a1-as-a-possible-biomarker-for-monitoring-treatment-of-canine-leishmaniosis
#3
Damián Escribano, Asta Tvarijonaviciute, Meric Kocaturk, Jose Joaquín Cerón, Luis Pardo-Marín, Alejandro Torrecillas, Zeki Yilmaz, Silvia Martínez-Subiela
The aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27865264/changes-in-serum-biomarkers-of-oxidative-stress-after-treatment-for-canine-leishmaniosis-in-sick-dogs
#4
Camila Peres Rubio, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Josefa Hernández-Ruiz, Luis Pardo-Marin, Sergi Segarra, José Joaquín Ceron
Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this study we investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infected by CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays total oxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) were included in the panel...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27854189/molecular-detection-of-leishmania-parasites-and-host-blood-meal-identification-in-wild-sand-flies-from-a-new-endemic-rural-region-south-of-iran
#5
Kourosh Azizi, Mohammad Bagher Askari, Mohsen Kalantari, Mohammad Djaefar Moemenbellah-Fard
Zoonotic Cutaneous Leishmaniosis (ZCL) remains the most crucial vector-borne public health disease particularly in endemic rural parts of Iran. The main aim of this study is to identify wild sand flies (Diptera: Psychodidae), determine their infection rate, and differentiate their host blood meal sources using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Sand fly populations were caught with sticky paper traps from 10 different villages in the county of Darab, Fars province, southern Iran...
November 17, 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27845489/leishmaniasis-and-ifn-%C3%AE-dependent-chemokines
#6
P Fallahi, G Elia, A Bonatti
Leishmaniasis is a disease caused by Leishmania and spread by the bite of certain types of sandflies. Leishmaniasis affects as many as 12 million people worldwide, with 2 million new cases each year. Leishmania infection, and Leishmaniasis, following occupational exposure has been also reported. Three forms of Leishmaniasis are known: a- Cutaneous Leishmaniasis (CL); b-Mucocutaneous Leishmaniasis; c- Visceral Leishmaniasis (VL). The visceral form of Leishmaniasis has an estimated incidence of 500,000 new cases...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27825341/essential-oils-in-vitro-activity-against-leishmania-amazonensis-cytotoxicity-and-chemical-composition
#7
Milene Aparecida Andrade, Clênia Dos Santos Azevedo, Flávia Nader Motta, Maria Lucília Dos Santos, Camila Lasse Silva, Jaime Martins de Santana, Izabela M D Bastos
BACKGROUND: The current chemotherapy for cutaneous leishmaniosis (CL) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the CL treatment. Essential oils (EOs) are complex mixtures of secondary metabolites from various plants. It has been shown that several EOs, or their constituents, have inhibitory activity against protozoa. Thus, this study aims to evaluate the biological activity of different essential oils (EOs) on Leishmania (L...
November 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27755675/nodular-granulomatous-glossitis-as-the-sole-clinical-sign-in-canine-leishmaniosis
#8
Melpomeni K Tangalidi, Ioannis L Oikonomidis, Dimitra Psalla, Serafim Papadimitriou, Maria Kritsepi-Konstantinou, Mathios E Mylonakis
A 5.5-year-old, intact male Rottweiler dog was admitted with a history of multifocal nodular tongue lesions which progressively deteriorated during the previous year. Physical examination revealed several reddish nodules with central depression on the surface of the tongue in an otherwise healthy dog. Clinicopathologic abnormalities included eosinophilia and hyperproteinemia. Lingual nodule cytopathology, histopathology, and immunohistochemistry revealed Leishmania spp. amastigotes and a severe granulomatous glossitis...
October 18, 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27720626/detection-of-leishmania-dna-and-blood-meal-sources-in-phlebotomine-sand-flies-diptera-psychodidae-in-western-of-spain-update-on-distribution-and-risk-factors-associated
#9
D Bravo-Barriga, R Parreira, C Maia, M O Afonso, J Blanco-Ciudad, F J Serrano, J E Pérez-Martín, L Gómez-Gordo, L Campino, D Reina, E Frontera
Leishmaniosis caused by Leishmania infantum is present in Mediterranean countries, with high prevalence in areas of the center and south of Spain. However, in some regions such as Extremadura (in southwest of Spain), data has not been updated since 1997. The aim of this work was (i) to provide information about the distribution of phlebotomine sand fly species in western of Spain (Extremadura region), (ii) to determine risk factors for the presence of sand fly vectors and (iii) to detect Leishmania DNA and identify blood meal sources in wild caught females...
October 5, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27692333/first-detection-of-leishmania-kdna-in-canine-cerumen-samples-by-qpcr
#10
Silvia Belinchón-Lorenzo, Juan Carlos Parejo, Virginia Iniesta, Javier Fernández-Cotrina, Rubén Muñoz-Madrid, Isabel Monroy, Victoria Baz, Adela Gómez-Luque, Francisco Javier Serrano-Aguilera, José Luis Barneto, Luis Carlos Gómez-Nieto
Nowadays, searching for alternative non-invasive methods for molecular diagnosis of canine visceral leishmaniosis is getting increasingly important. We previously described the presence of Leishmania kinetoplast DNA (kDNA) in canine hair; in this case we hypothesized whether foreign DNA might be present in cerumen of dogs with leishmaniosis, and be detected by Real time quantitative PCR (qPCR). A population of 38 dogs that lived in Leishmania endemic areas was divided in two groups: A (33 dogs with confirmed leishmaniosis by serological techniques) and B (5 healthy dogs)...
September 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27692322/tlr-2-and-tlr-4-transcriptions-in-unstimulated-blood-from-dogs-with-leishmaniosis-due-to-leishmania-infantum-at-the-time-of-diagnosis-and-during-follow-up-treatment
#11
Sara Montserrat-Sangrà, Lorena Alborch, Laura Ordeix, Laia Solano-Gallego
Innate immunity, in particular, the role of toll-like receptors (TLRs), has not been extensively studied in canine L. infantum infection. The main aim of this study was to determine the transcription of TLR2 and TLR4 in the blood of dogs with natural clinical leishmaniosis at the time of diagnosis and during treatment follow-up and subsequently correlate these findings with clinical, serological and parasitological data. Forty-six Leishmania-seropositive sick dogs with a high antibody level at the time of diagnosis were studied and compared with 34 healthy seronegative dogs...
September 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27682867/natural-products-as-a-source-for-antileishmanial-and-antitrypanosomal-agents
#12
Marcus Tullius Scotti, Luciana Scotti, Hamilton Ishiki, Frederico Fávaro Ribeiro, Rayssa Marques Duarte da Cruz, Michelle Pedrosa de Oliveira, Francisco Jaime Bezerra Mendonça
Natural products are compounds extracted from plants, marine organisms, fungi or bacteria. Many researches for new drugs are based on these natural molecules, mainly by beneficial effects on health, health, efficacy, and therapeutic safety. Leishmaniosis, Chagas disease and African sleeping sickness are neglected diseases caused by the Leishmania and Trypanosoma ssp. parasites. These infections mainly affect population of developing countries; they have different symptoms, and may often lead to death. The therapeutic drugs available to treat these diseases are either obsolete, toxic, or have questionable efficacy, possibly through encountering resistance...
2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27638124/a-minimally-invasive-approach-to-spleen-histopathology-in-dogs-a-new-method-for-follow-up-studies-of-spleen-changes-in-the-course-of-leishmania-infantum-infection
#13
Silvana Ornelas Santos, Jonathan L M Fontes, Daniela F Laranjeira, José Vassallo, Stella Maria Barrouin-Melo, Washington L C Dos-Santos
Severe forms of zoonotic visceral leishmaniosis (ZVL) are associated with disruption of the spleen structure. However, the study of spleen histology requires splenectomy or necropsy. In this work, we present a minimally invasive cell-block technique for studying spleen tissue histology in dogs with ZVL. We examined 13 dogs with and seven dogs without Leishmania infantum infection. The dogs with Leishmania infection had a lower frequency of lymphoid follicles (2/13, Fisher's test, P<0.02) and a higher density of plasma cells (score 3, Fisher's test, P<0...
October 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27632527/field-evaluation-of-two-different-treatment-approaches-and-their-ability-to-control-fleas-and-prevent-canine-leishmaniosis-in-a-highly-endemic-area
#14
Emanuele Brianti, Ettore Napoli, Gabriella Gaglio, Luigi Falsone, Salvatore Giannetto, Fabrizio Solari Basano, Roberto Nazzari, Maria Stefania Latrofa, Giada Annoscia, Viviana Domenica Tarallo, Dorothee Stanneck, Filipe Dantas-Torres, Domenico Otranto
This study investigated the efficacy of two collars for the treatment and prevention of flea infestations. Additionally the effect of these collars on the incidence of Leishmania infantum infection as compared with a group of vaccinated dogs was evaluated. A total of 224 young dogs from private animal shelters were enrolled in April/May into four groups: G1, 55 dogs treated with 10% imidacloprid + 4.5% flumethrin collar (Seresto, Bayer Animal Health); G2, 60 dogs treated with 4% deltamethrin collar (Scalibor protector band, MSD Animal Health); G3, 54 dogs vaccinated with CaniLeish (Virbac Animal Health); and G4, 55 dogs left non-treated as controls...
September 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27594282/seroprevalence-of-leishmaniasis-among-dogs-living-in-a-municipal-dog-and-cat-shelter-in-edirne
#15
Ayşe Düzbeyaz, Nermin Şakru, Seray Töz
OBJECTIVE: In this study, we aimed to investigate the seroprevalence of canine leishmaniosis among dogs that live in the town center due to a lack of data on the prevalence of canine leishmaniasis (CanL) in Edirne. METHODS: In the present study, 37 dogs living in a municipal dog and cat shelter in Edirne were screened for leishmaniosis by the ındirect fluorescent antibody test. RESULTS: All samples were found to be seronegative. CONCLUSION: Our study is a preliminary study for Edirne...
December 0: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27580400/influence-of-apoptosis-on-liver-and-spleen-resistance-in-dogs-with-visceral-leishmaniosis
#16
Pamela Rodrigues Reina Moreira, Douglas Augusto Franciscato, Sabrina Micelli Rossit, Danísio Prado Munari, Rosemeri de Oliveira Vasconcelos
The aim of this study was to evaluate apoptosis and parasite load in the liver and spleen of dogs with visceral leishmaniosis (VL), using immunohistochemistry. Liver and spleen samples from 71 dogs with VL were used. The parasite load in the spleen and liver showed significant difference between organs in infected group (P=0.0219). The density of the parasite load in the spleen (median=2.4) was higher than liver (median=0.8). Immunodetection of apoptotic cells was predominant in lymphocytes and differ between the infected and control group in spleen (P=0...
July 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27549209/erratum-to-leishmania-infantum-specific-production-of-ifn-%C3%AE-and-il-10-in-stimulated-blood-from-dogs-with-clinical-leishmaniosis
#17
Laia Solano-Gallego, Sara Montserrat-Sangrà, Laura Ordeix, Pamela Martínez-Orellana
No abstract text is available yet for this article.
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27468032/leishmania-infantum-infection-in-bennett-s-wallabies-macropus-rufogriseus-rufogriseus-in-a-spanish-wildlife-park
#18
Ana Montoya, Lino Pérez de Quadros, Marta Mateo, Leticia Hernández, Rosa Gálvez, Gabriel Alcántara, Rocío Checa, María Ángeles Jiménez, Carmen Chicharro, Israel Cruz, Guadalupe Miró
Although dogs are the main reservoir for human Leishmania infantum infection, the disease has also been reported in other domestic and wild mammals. In 2011, a fatal case of naturally acquired leishmaniosis was described for the first time in a Bennett's wallaby (Macropus rufogriseus rufogriseus) kept in a wildlife park in Madrid (Spain). This study was designed to assess the infection status of twelve Bennett's wallabies in the same park one year after this incident. Phlebotomus perniciosus, the main vector of L...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27393092/evaluation-of-hypoxia-inducible-factor-targeting-pharmacological-drugs-as-antileishmanial-agents
#19
Marina Dal'Bó Pelegrini, Juliana Biar Pereira, Solange Dos Santos Costa, Myriam Janeth Salazar Terreros, Adriana Degrossoli, Selma Giorgio
OBJECTIVE: To evaluate whether hypoxia inducible factor (HIF-1α) targeting pharmacological drugs, echinomycin, resveratrol and CdCl2 which inhibit HIF-1α stimulation, and mimosine, which enhances the stability of HIF-1α present antileishmanial properties. METHODS: The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous leishmaniosis. RESULTS: Resveratrol and CdCl2 reduced the parasite load [IC50, (27...
July 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27283147/common-skin-infection-due-to-panton-valentine-leucocidin-producing-staphylococcus-aureus-strains-in-asylum-seekers-from-eritrea-a-genome-based-investigation-of-a-suspected-outbreak
#20
L Jaton, T Pillonel, K Jaton, E Dory, G Prod'hom, D S Blanc, F Tissot, P Bodenmann, G Greub
Since late 2014, multiple cases of abscesses and boils due to methicillin-susceptible Staphylococcus aureus (MSSA) expressing the Panton-Valentine leucocidin (PVL) were observed in Eritrean asylum seekers in Lausanne, Switzerland. Strains isolated from infected Eritrean and non-Eritrean patients were compared by whole genome sequencing to determine whether these numerous cases result from an outbreak. The genome of S. aureus PVL-producing strains were sequenced and compared. Clinical and epidemiological characteristics of patients infected by PVL-producing strains were investigated...
August 2016: Clinical Microbiology and Infection
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