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https://www.readbyqxmd.com/read/28424022/analytical-validation-of-an-automated-assay-for-ferric-reducing-ability-of-plasma-in-dog-serum
#1
Camila Peres Rubio, Silvia Martinez-Subiela, Josefa Hernández-Ruiz, Asta Tvarijonaviciute, José Joaquín Ceron
We performed analytical validation of an automated ferric-reducing ability of plasma (FRAP) assay in the serum of dogs. Intra- and interassay precision, accuracy, detection limit, and effects of hemolysis and lipemia were evaluated. Intra- and interassay coefficients of variation were <1% and <13%, respectively. The assay showed a high correlation with a FRAP assay described previously, and results were linear when serial sample dilutions were tested. The detection limit was lower than the values observed in sera from healthy dogs; decreased serum FRAP was found in dogs with leishmaniosis...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28420407/understanding-phlebotomus-perniciosus-abundance-in-south-east-spain-assessing-the-role-of-environmental-and-anthropic-factors
#2
José Risueño, Clara Muñoz, Pedro Pérez-Cutillas, Elena Goyena, Moisés Gonzálvez, María Ortuño, Luis Jesús Bernal, Juana Ortiz, Bulent Alten, Eduardo Berriatua
BACKGROUND: Leishmaniosis is associated with Phlebotomus sand fly vector density, but our knowledge of the environmental framework that regulates highly overdispersed vector abundance distributions is limited. We used a standardized sampling procedure in the bioclimatically diverse Murcia Region in Spain and multilevel regression models for count data to estimate P. perniciosus abundance in relation to environmental and anthropic factors. METHODS: Twenty-five dog and sheep premises were sampled for sand flies using adhesive and light-attraction traps, from late May to early October 2015...
April 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28385540/performance-of-leishmania-braziliensis-enolase-protein-for-the-serodiagnosis-of-canine-and-human-visceral-leishmaniosis
#3
Mariana Costa Duarte, Daniela Pagliara Lage, Vívian Tamietti Martins, Lourena Emanuele Costa, Beatriz Cristina Silveira Salles, Ana Maria Ravena Severino Carvalho, Thaís Teodoro de Oliveira Santos, Daniel Silva Dias, Patrícia Aparecida Fernandes Ribeiro, Miguel Angel Chávez-Fumagalli, Ricardo Andrez Machado-de-Ávila, Bruno Mendes Roatt, Daniel Menezes-Souza, Danielle Ferreira de Magalhães-Soares, Eduardo Antonio Ferraz Coelho
In the present study, Leishmania braziliensis enolase was cloned and the recombinant protein (rEnolase) was evaluated for the serodiagnosis of canine and human visceral leishmaniosis (VL). For the canine VL diagnosis, this study examined serum samples of Leishmania infantum-infected dogs, from non-infected animals living in endemic or non-endemic areas of leishmaniosis, as well as those from Leish-Tec(®)-vaccinated dogs and Trypanosoma cruzi or Ehrlichia canis experimentally infected animals. For the human VL diagnosis, this study analyzed serum samples from VL patients, from non-infected subjects living in endemic or non-endemic areas of leishmaniosis, as well as those from T...
March 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28367456/synthetic-peptides-as-potential-antigens-for-cutaneous-leishmaniosis-diagnosis
#4
Juliana Seger Link, Silvana Maria Alban, Carlos Ricardo Soccol, Gilberto Vinicius Melo Pereira, Vanete Thomaz Soccol
This work's goal was to research new candidate antigens for cutaneous leishmaniosis (CL). In order to reach the goal, we used random peptide phage display libraries screened using antibodies from Leishmania braziliensis patients. After selection, three peptides (P1, P2, and P3) were synthesized using Fmoc chemistry. The peptides individually or a mixture of them (MIX) was subsequently emulsified in complete and incomplete Freund's adjuvant and injected subcutaneously in golden hamsters. Sera from the hamsters administered with P1 presented antibodies that recognized proteins between 76 and 150 kDa from L...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28338625/-r-aloesaponol-iii-8-methyl-ether-from-eremurus-persicus-a-novel-compound-against-leishmaniosis
#5
Daniela Rossi, Karzan Mahmood Ahmed, Raffaella Gaggeri, Serena Della Volpe, Lauretta Maggi, Giuseppe Mazzeo, Giovanna Longhi, Sergio Abbate, Federica Corana, Emanuela Martino, Marisa Machado, Raquel Varandas, Maria do Céu Sousa, Simona Collina
Leishmaniosis is a neglected tropical disease which affects several millions of people worldwide. The current drug therapies are expensive and often lack efficacy, mainly due to the development of parasite resistance. Hence, there is an urgent need for new drugs effective against Leishmania infections. As a part of our ongoing study on the phytochemical characterization and biological investigation of plants used in the traditional medicine of western and central Asia, in the present study, we focused on Eremurus persicus root extract in order to evaluate its potential in the treatment of leishmaniosis...
March 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28288759/feline-and-canine-leishmaniosis-and-other-vector-borne-diseases-in-the-aeolian-islands-pathogen-and-vector-circulation-in-a-confined-environment
#6
Domenico Otranto, Ettore Napoli, Maria Stefania Latrofa, Giada Annoscia, Viviana Domenica Tarallo, Grazia Greco, Eleonora Lorusso, Laura Gulotta, Luigi Falsone, Fabrizio Solari Basano, Maria Grazia Pennisi, Katrin Deuster, Gioia Capelli, Filipe Dantas-Torres, Emanuele Brianti
Vector-borne diseases (VBDs) are prevalently investigated in dogs. Studies on feline VBDs are scant, though feline leishmaniosis (FeL) is increasingly recognised as a disease of cats in endemic areas. Comprehensive investigations on the distribution of VBDs in populations of cats and dogs living in relatively small geographical areas, such as islands, are currently lacking. In this study the prevalence of Leishmania infantum and other VBD pathogens was assessed in cohorts of cats and dogs living in the Aeolian Islands...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28288677/the-inflammatory-cytokine-effect-of-pam3csk4-tlr2-agonist-alone-or-in-combination-with-leishmania-infantum-antigen-on-ex-vivo-whole-blood-from-sick-and-resistant-dogs
#7
Pamela Martínez-Orellana, Paulina Quirola-Amores, Sara Montserrat-Sangrà, Laura Ordeix, Joan Llull, Alejandra Álvarez-Fernández, Laia Solano-Gallego
BACKGROUND: A wide spectrum of clinical manifestations and immune responses exist in canine L. infantum infection. Ibizan hounds are more "resistant" to disease than other dog breeds. Recognition of pathogen-associated molecule patterns by toll like receptors (TLRs) rapidly triggers a variety of anti-microbial immune responses through the induction of pro-inflammatory cytokines such as TNF-α and IL-6 which may play an important role in controlling Leishmania infection. The main objective of this study was to investigate and compare the effect of a TLR2 agonist (TLR2a) alone or in combination with L...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28288670/histological-and-parasitological-distinctive-findings-in-clinically-lesioned-and-normal-looking-skin-of-dogs-with-different-clinical-stages-of-leishmaniosis
#8
Laura Ordeix, Annabel Dalmau, Montsant Osso, Joan Llull, Sara Montserrat-Sangrà, Laia Solano-Gallego
BACKGROUND: Normal-looking skin of dogs with leishmaniosis frequently shows microscopic lesions along with the presence of Leishmania amastigotes. However, histological lesions with or without detection of amastigotes might not occur in less severe clinical cases. In addition, comparative studies between paired clinically-lesioned and normal-looking skin samples from dogs with different disease severity are lacking. The objective of this study was to compare histological and parasitological findings by Leishmania immunohistochemistry (IHC) and quantitative PCR (qPCR) on paired clinically-lesioned and normal-looking skin biopsies from 25 dogs with different clinical stages of leishmaniosis, 11 with stage I-mild disease (papular dermatitis) and 14 with stage II-III (ulcerative or exfoliative dermatitis)...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28285601/canine-leishmaniosis-caused-by-leishmania-major-and-leishmania-tropica-comparative-findings-and-serology
#9
Gad Baneth, Daniel Yasur-Landau, Matan Gilad, Yaarit Nachum-Biala
BACKGROUND: Infection and clinical disease associated with Leishmania major and Leishmania tropica, two common agents of human cutaneous leishmaniosis, have rarely been reported in dogs. This study describes dogs infected with these Leishmania spp. prevalent in the Middle East and North Africa, and compares the serological response of dogs infected with Leishmania infantum, L. major or L. tropica to whole promastigote antigen enzyme-linked immunosorbent assay (ELISA) of each species and to rK39 dipstick...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28285598/diagnostic-performance-of-elisa-ifat-and-western-blot-for-the-detection-of-anti-leishmania-infantum-antibodies-in-cats-using-a-bayesian-analysis-without-a-gold-standard
#10
Maria Flaminia Persichetti, Laia Solano-Gallego, Angela Vullo, Marisa Masucci, Pierre Marty, Pascal Delaunay, Fabrizio Vitale, Maria Grazia Pennisi
BACKGROUND: Anti-Leishmania antibodies are increasingly investigated in cats for epidemiological studies or for the diagnosis of clinical feline leishmaniosis. The immunofluorescent antibody test (IFAT), the enzyme-linked immunosorbent assay (ELISA) and western blot (WB) are the serological tests more frequently used. The aim of the present study was to assess diagnostic performance of IFAT, ELISA and WB to detect anti-L. infantum antibodies in feline serum samples obtained from endemic (n = 76) and non-endemic (n = 64) areas and from cats affected by feline leishmaniosis (n = 21) by a Bayesian approach without a gold standard...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28285587/serological-association-between-leishmania-infantum-and-sand-fly-fever-sicilian-but-not-toscana-virus-in-sheltered-dogs-from-southern-portugal
#11
Carla Maia, Sulaf Alwassouf, José Manuel Cristóvão, Nazli Ayhan, André Pereira, Remi N Charrel, Lenea Campino
BACKGROUND: Phlebotomine sand fly-borne diseases such as leishmanioses and phleboviruses are emerging threats to animal and public health. Canine leishmaniosis caused by Leishmania infantum is an endemic zoonosis in Portugal. Antibodies to Toscana virus (TOSV) and sand fly fever Sicilian virus (SFSV) were also reported in dogs from the south of the country. The aim of this work was to evaluate a possible association between exposure to L. infantum, TOSV and SFSV in sheltered dogs from the south of Portugal...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28279490/canine-leishmaniosis-in-three-consecutive-generations-of-dogs-in-czech-republic
#12
Vlasta Svobodova, Miroslav Svoboda, Lucia Friedlaenderova, Petr Drahotsky, Eva Bohacova, Gad Baneth
Transmission of canine leishmaniosis (CanL) is described in three consecutive generations of female Boxers living in a non-endemic environment in the Czech Republic. Infection of the first generation female likely occurred during a breeding visit to Italy and the dog died with typical clinical signs of the disease but without definitive laboratory diagnosis. The second and third generation offsprings never left the Czech Republic, suffered from clinical CanL confirmed by polymerase chain reaction and serology, and were apparently infected by transplacental transmission...
February 27, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28161232/-correctly-address-the-cause-of-hemophagocytic-lymphohistiocytosis
#13
M Penel-Page, B Ben Said, A Phan, L Hees, C Hartmann-Merlin, S Girard, Y Gillet, A Belot
Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe syndrome usually associated with a cytotoxicity deficiency, which leads to an excess of immune response driven by activated macrophages and cytotoxic T cells. In children, HLH can be genetic, as part of a familial lymphohistiocytosis, or secondary: the most frequent causes are systemic-onset juvenile idiopathic arthritis, hematological malignancies, and severe infections, especially with Ebstein-Barr virus or leishmaniosis. We report on the case of a 3-year-old girl with no past medical history, who presented inaugural Pseudomonas aeruginosa maxillary osteitis, with secondary HLH...
February 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28133824/a-retrospective-study-comparing-histopathological-and-immunopathological-features-of-nasal-planum-dermatitis-in-20-dogs-with-discoid-lupus-erythematosus-or-leishmaniosis
#14
Michela De Lucia, Giorgia Mezzalira, Mar Bardagí, Dolors M Fondevila, Elisabetta Fabbri, Alessandra Fondati
BACKGROUND: In areas endemic for leishmaniosis, discoid lupus erythematosus (DLE) and canine leishmaniosis (CanL) are the most common differential diagnoses for nasal planum erosive-ulcerative dermatitis in dogs. HYPOTHESIS/OBJECTIVE: To compare histopathological and immunopathological features of canine nasal planum erosive-ulcerative dermatitis with depigmentation due to DLE or CanL. ANIMALS: Nasal planum biopsies from dogs with nasal planum loss of architecture, depigmentation, swelling, erosions or ulcerations due to DLE (n = 14) or CanL (n = 6)...
January 29, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28114941/evaluation-of-various-biomarkers-for-kidney-monitoring-during-canine-leishmaniosis-treatment
#15
Luis Pardo-Marín, Silvia Martínez-Subiela, Josep Pastor, Asta Tvarijonaviciute, Juan Diego Garcia-Martinez, Sergi Segarra, José Joaquín Cerón
BACKGROUND: The objective of this study was to evaluate and compare the evolution of the profile currently recommended by the International Renal Interest Society (IRIS) (sCr, UPC and sSDMA) with a panel of other different kidney biomarkers during treatment for canine leishmaniosis. This panel included three urinary glomerular biomarkers (uIgG, uCRP and uferritin) and three urinary tubular biomarkers (uGGT, uNAG and uRBP). These biomarkers were measured in two groups of dogs with canine leishmaniosis at IRIS stage I...
January 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/27977059/comparison-of-a-rapid-immunochromatographic-assay-with-an-immunofluorescent-antibody-test-for-detection-of-leishmania-infantum-antibodies-in-dogs
#16
Daniela Proverbio, Eva Spada, Roberta Perego, Luciana Baggiani, Giada Bagnagatti De Giorgi, Antonella Migliazzo, Fabrizio Vitale
BACKGROUND: Identification of Leishmania infantum-infected dogs is crucial for control of canine leishmaniosis. In particular, in areas where access to specialized laboratories is limited, the availability of reliable and rapid in-clinic serologic tests may support immediate diagnosis in suspected cases and permit detection of asymptomatic canine carriers of L infantum infection. OBJECTIVE: The purpose of the study was to validate the immunochromatographic test (ICT) Anigen Rapid Leishmania Ab Test kit for detection of L infantum antibodies in naturally exposed dogs in comparison with the immunofluorescence antibody test (IFAT)...
December 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27935542/otolaryngological-manifestations-of-leishmaniosis
#17
Piotr Kurnatowski, Jakub Moroz
Travel to developing countries is associated with possibility to acquire different, also parasitic, diseases which have become a diagnostic and therapeutic problem. The ENT specialist is one of the medical officers who may make initial contact with a patient with a suspected parasitic disease. One of them is leishmaniosis: a parasitic disease classified as Neglected Tropical Diseases (NTD), which occurs in the tropics, subtropics and southern Europe. While asymptomatic invasion is observed in some cases, three forms of symptomatic leishmaniosis can be distinguished: cutaneous leishmaniosis (CL), visceral leishmaniosis (VL), and mucosal leishmaniosis (ML)...
October 31, 2016: Otolaryngologia Polska
https://www.readbyqxmd.com/read/27895289/management-prevention-and-treatment-of-canine-leishmaniosis-in-north-eastern-spain-an-online-questionnaire-based-survey-in-the-province-of-girona-with-special-emphasis-on-new-preventive-methods-canileish-vaccine-and-domperidone
#18
S Lladró, A Picado, C Ballart, M Portús, M Gállego
Knowledge of how canine leishmaniosis (CanL) is being managed clinically and its epidemiology is very important, since dogs are the main reservoir of human leishmaniosis. This study reports the results obtained through a questionnaire-based survey of veterinary practitioners in Girona province, a recognised, but non-documented endemic area in north-eastern Spain. The primary objective was to obtain data on the clinical management of CanL, focusing particularly on new preventive methods and therapeutic tools...
January 14, 2017: Veterinary Record
https://www.readbyqxmd.com/read/27892869/serum-c-reactive-protein-and-ferritin-concentrations-in-dogs-undergoing-leishmaniosis-treatment
#19
Silvia Martinez-Subiela, Luis Pardo-Marín, Fernando Tecles, Gad Baneth, Jose J Cerón
Monitoring of selected serum acute phase proteins like C-reactive protein (CRP) and ferritin could be useful for evaluation of the response to treatment in both naturally-occurring and experimentally-induced leishmaniosis. However studies until date have only been focused on dogs with an adequate response to the treatment and there is a lack of knowledge about the possible associations between the CRP and ferritin and the different clinicopathological conditions that can appear after treatment. Thus, the main objective of this retrospective study was to evaluate and compare the serum concentration of CRP and ferritin between three possible situations that dogs which undergo leishmaniosis treatment could have: responsive with total recovery, responsive with only clinical recovery but persistent abnormalities in biochemical analytes, and unresponsive with clinical and biochemical changes...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27865270/serum-apolipoprotein-a1-as-a-possible-biomarker-for-monitoring-treatment-of-canine-leishmaniosis
#20
Damián Escribano, Asta Tvarijonaviciute, Meric Kocaturk, Jose Joaquín Cerón, Luis Pardo-Marín, Alejandro Torrecillas, Zeki Yilmaz, Silvia Martínez-Subiela
The aims of this study were: the identification of proteins differentially represented in the serum proteome of dogs with leishmaniosis after treatment and the verification of one selected protein as a possible biomarker for treatment monitoring. Serum samples from five dogs with leishmaniosis, before and after treatment were pooled into two groups and analysed using 2-dimensional electrophoresis followed by mass spectrometry analysis (MS). The MS analysis allowed the identification of 8 proteins differently expressed...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
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