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Leishmaniosis

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https://www.readbyqxmd.com/read/29174223/novel-areas-for-prevention-and-control-of-canine-leishmaniosis-trends-in-parasitology-33-718-730-2017
#1
Guadalupe Miró, Christine Petersen, Luís Cardoso, Patrick Bourdeau, Gad Baneth, Laia Solano-Gallego, Maria Grazia Pennisi, Lluís Ferrer, Gaetano Oliva
No abstract text is available yet for this article.
November 23, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/29173539/leishmania-infantum-specific-ifn-%C3%AE-production-in-stimulated-blood-from-dogs-with-clinical-leishmaniosis-at-diagnosis-and-during-treatment
#2
Pamela Martínez-Orellana, Daniel Marí-Martorell, Sara Montserrat-Sangrà, Laura Ordeix, Gad Baneth, Laia Solano-Gallego
There is limited data regarding Leishmania infantum specific T cell mediated immunity in naturally infected sick dogs at the time of diagnosis and during anti-Leishmania treatment. Our aim was to investigate the kinetics of L. infantum specific IFN-γ production in dogs with leishmaniosis at the time of diagnosis and during treatment and to correlate it with specific L. infantum antibodies, blood parasitemia and clinicopathological findings. Thirty-four dogs were diagnosed with leishmaniosis based on physical examination, routine laboratory tests and L...
December 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29173534/canine-neutrophils-activate-effector-mechanisms-in-response-to-leishmania-infantum
#3
REVIEW
Maria Pereira, Ana Valério-Bolas, David Santos-Mateus, Graça Alexandre-Pires, Marcos Santos, Armanda Rodrigues, Hugo Rocha, Ana Santos, Catarina Martins, Ana Tomas, Filipe Passero, Isabel Pereira da Fonseca, Gabriela Santos-Gomes
Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis by the phlebotomine vector. To study the interaction of dog neutrophils and L. infantum promastigotes, blood neutrophils were isolated from healthy donors and the infection was established in vitro. In the majority of the dogs, L. infantum was efficiently phagocytized by neutrophils, and oxidative (superoxide production) and non-oxidative (neutrophil elastase exocytosis) intracellular effector mechanisms were activated, but the release of neutrophil extracellular traps was minimized...
December 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29164321/canine-leishmania-infantum-infection-an-imported-case-in-uk-after-staying-in-the-canary-islands
#4
J R S Dandrieux, F Sacchini, G Harms, M Globokar, H-J Balzer, Nikola Pantchev
Leishmaniosis is reported in the Iberian Peninsula and the Balearic Islands, but the Canary Islands are deemed free. In the present communication, we report a clinical leishmaniosis due to Leishmania infantum in a dog that was presumptively infected during its stay on Tenerife. The result of Leishmania serology (whole-cell based ELISA with L. infantum antigen) was high positive (test score of 82.2 at a cut-off value of 12.0). This result was further confirmed with quantitative real-time polymerase chain reaction (qPCR) for Leishmania spp...
November 21, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29163980/follow-up-monitoring-in-a-cat-with-leishmaniosis-and-coinfections-with-hepatozoon-felis-and-candidatus-mycoplasma-haemominutum
#5
Charalampos Attipa, Kyriaki Neofytou, Christos Yiapanis, Pamela Martínez-Orellana, Gad Baneth, Yaarit Nachum-Biala, Harriet Brooks-Brownlie, Laia Solano-Gallego, Séverine Tasker
Case summary: A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hepatozoon species and 'Candidatus Mycoplasma haemominutum' (CMhm) DNA. Subsequent sequencing identified Hepatozoon felis...
July 2017: JFMS Open Reports
https://www.readbyqxmd.com/read/29155831/prevalence-and-risk-factors-associated-with-leishmania-infection-in-trang-province-southern-thailand
#6
Jipada Manomat, Saovanee Leelayoova, Lertwut Bualert, Peerapan Tan-Ariya, Suradej Siripattanapipong, Mathirut Mungthin, Tawee Naaglor, Phunlerd Piyaraj
BACKGROUND: Autochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients. METHODS: A cross-sectional study was conducted to determine the prevalence and risk factors associated with Leishmania infection among patients with HIV/AIDS living in Trang province, southern Thailand, between 2015 and 2016...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29153900/clinicopathological-findings-in-sick-dogs-naturally-infected-with-leishmania-infantum-comparison-of-five-different-clinical-classification-systems
#7
A Meléndez-Lazo, L Ordeix, M Planellas, J Pastor, L Solano-Gallego
A wide spectrum of clinical and clinicopathological findings in dogs with canine leishmaniosis (CanL) due to Leishmania infantum exists. However, the majority of clinical descriptions have been published a long time ago and recent studies in Europe are almost lacking. In addition, clinical classification of sick dogs is not well-standardized, with different classification systems used by clinical and epidemiological studies, making comparison of studies a difficult task. The aims of the study were to describe the clinicopathological findings of dogs naturally infected with L...
November 10, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29100256/radiological-diagnoses-in-the-context-of-emigration-infectious-diseases
#8
Marija Stoijkovic, Jan Müller, Thomas Junghanss, Tim Frederik Weber
Background Globalization and emigration impact on the spectrum of diseases challenging health care systems. Medical practitioners have to particularly prepare for infectious diseases. Methods The database of a health care center specialized on tropical medicine was screened for patients with history of migration and one of the following diagnoses: Cystic echinococcosis, tuberculosis, schistosomiasis, visceral leishmaniosis, and neurocysticercosis. Representative casuistics were prepared from select case histories...
November 3, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29092797/gold-nanoparticles-against-parasites-and-insect-vectors
#9
REVIEW
Giovanni Benelli
Nanomaterials are currently considered for many biological, biomedical and environmental purposes, due to their outstanding physical and chemical properties. The synthesis of gold nanoparticles (Au NPs) is of high interest for research in parasitology and entomology, since these nanomaterials showed promising applications, ranging from detection techniques to drug development, against a rather wide range of parasites of public health relevance, as well as on insect vectors. Here, I reviewed current knowledge about the bioactivity of Au NPs on selected insect species of public health relevance, including major mosquito vectors, such as Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus...
October 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29061137/performance-of-leishmania-pfr1-recombinant-antigen-in-serological-diagnosis-of-asymptomatic-canine-leishmaniosis-by-elisa
#10
Darién Ledesma, Eduardo Berriatua, M Carmen Thomas, Luis Jesús Bernal, María Ortuño, Celia Benitez, Adriana Egui, Kostas Papasouliotis, Bryn Tennant, Julia Chambers, Juan José Infante, Manuel Carlos López
BACKGROUND: Leishmania infantum is a protozoan parasite transmitted by phlebotomine sand flies that causes life-threatening disease in humans and dogs. The dog is the primary reservoir of the parasite and early diagnosis of canine leishmaniosis is crucial at the clinical and epidemiological level. The currently available serological tests for CanL diagnostic show limitations therefore the aim of the present study was to investigate the diagnostic performance of an indirect antibody ELISA based on the Leishmania infantum recombinant antigen PFR1 in asymptomatically infected dogs...
October 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29045624/long-term-cell-culture-isolated-from-lesions-of-mice-infected-with-leishmania-amazonensis-a-new-approach-to-study-mononuclear-phagocyte-subpopulations-during-the-infection
#11
Myriam Janeth Salazar Terreros, Luis Augusto Visani de Luna, Selma Giorgio
Leishmanioses are neglected diseases and the parasite Leishmania survives and proliferates within mononuclear phagocytes, particularly macrophages. In vitro studies of the immunology and cell biology of leishmaniosis are performed in murine peritoneum and bone marrow macrophages and immortalized cell lines despite the normal and injured tissue-specific heterogeneity of macrophages. In this work, we established an ex vivo methodology to culture lesional cells from BALB/c mice infected with Leishmania amazonensis...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28986939/leishmania-infection-in-rodents-in-greece
#12
Ιoannis Tsakmakidis, Katerina Angelopoulou, Chrysostomos I Dovas, Εmmanouil Dokianakis, Αndroniki Tamvakis, Isaia Symeonidou, Μaria Antoniou, Αnastasia Diakou
OBJECTIVE: To investigate the prevalence of Leishmania infection in rodents from various areas of Northern Greece. METHODS: 97 rodents (66 Mus musculus, 18 Rattus norvegicus and 12 R. rattus) were collected during pest control programs and examined by cytology (spleen and liver smears), serology (ELISA) and PCR (real-time and gel-based) for Leishmania. Date, environment, sex, existence of dogs in the close environment were recorded for each rodent. All cytological preparations were negative, whereas specific IgG were detected in 54...
October 6, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28979340/iranian-native-plants-on-treatment-of-cutaneous-leishmaniosis-a-narrative-review
#13
REVIEW
Elham Moghaddas, Ali Khamesipour, Mehdi Mohebali, Abdolmajid Fata
BACKGROUND: Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosin, and allopurinol. In this study, we explained about the native plant that grows in different regions of Iran and used as anti-leishmanial in Iran and even many other countries. METHODS: This narrative review covers all information about local herbal medicine in Iran that used in treatment of cutaneous leishmaniasis in all the worlds, published in local and international journals from 1996 to 2015 using various databases including PubMed, SID, Google Scholar, Scopus, and Science Direct...
July 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28929498/dog-skin-parasite-load-tlr-2-il-10-and-tnf-%C3%AE-expression-and-infectiousness
#14
D C M Pereira-Fonseca, F M Oliveira-Rovai, L A C Rodas, C A C Beloti, R B P Torrecilha, P K R K Ito, S V Avanço, R S Cipriano, Y T Utsunomiya, R M Hiramoto, L Calvo-Bado, O Courtenay, G F Machado, V M F Lima, C M Nunes
Visceral leishmaniosis is a zoonotic disease that is transmitted by Lutzomyia longipalpis sandflies. Dogs are the main peri-urban reservoir of the disease, and progression of canine leishmaniosis is dependent on the type of immune response elaborated against the parasite. Type 1 immunity is characterized by effective cellular response, with production of pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF-α). In contrast, Type 2 immunity is predominantly humoral, associated with progression of the disease and mediated by anti-inflammatory cytokines such as interleukin 10 (IL-10)...
November 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28915996/alternative-strategy-for-visceral-leishmaniosis-control-hisak70-salmonella-choleraesuis-pulsed-dendritic-cells
#15
Gustavo Domínguez-Bernal, Abel Martínez-Rodrigo, Alicia Mas, M Mar Blanco, José A Orden, Ricardo De La Fuente, Javier Carrión
Here, we describe a novel approach that exploits an attenuated mutant of Salmonella enterica serovar Choleraesuis as carrier to deliver a plasmid encoding protein HisAK70. Subsequently, dendritic cells (DCs) were pulsed with this vaccine vector. The aim of this study was to evaluate the effectiveness of the prepared HisAK70-S. Choleraesuis-pulsed DCs (HisAK70-SAL DCs) against visceral leishmaniosis (VL). In our ex vivo model of infection, the prepared formulations could decrease parasite growth by up to 80% by augmenting the production of IL-12p40 and by reducing arginase activity (ARG)...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28895868/identification-of-novel-biomarkers-for-treatment-monitoring-in-canine-leishmaniosis-by-high-resolution-quantitative-proteomic-analysis
#16
Silvia Martinez-Subiela, Anita Horvatic, Damian Escribano, Luis Pardo-Marin, Meric Kocaturk, Vladimir Mrljak, Richard Burchmore, Jose J Ceron, Zeki Yilmaz
The objective of this study was to use the Tandem Mass Tag (TMT) isobaric label-based proteomic approach, in order to identify new potential biomarkers for the treatment monitoring of canine leishmaniosis that could not be identified by the use of gel-based techniques. For this purpose serum samples were obtained from 5 clinically diseased dogs before and one month after the treatment of canine leishmaniosis. The non-depleted serum samples were subjected to reduction, alkylation and trypsin digestion, and the resulting peptides were labeled using 6-plex TMT reagents...
September 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28892427/norwegian-or-crusted-sarcoptic-mange-in-two-leishmanial-dogs
#17
Flora Kaltsogianni, Rania Farmaki, Alexander F Koutinas
Norwegian or crusted scabies (N/CS) is a rare skin disease with very few cases reported in the dog or the cat. Two adult, stray dogs were admitted in our clinic with a generalized, multifocal to diffuse and nonpruritic dermatitis that was characterized by severe crusting, scaling, and ulceration. In both instances, leishmaniosis and N/CS were diagnosed by immunofluorescent antibody test serology, lymph node cytology, and skin scrapings in which high numbers of Sarcoptes mites were found. The combination of miticidal and antileishmanial treatment, supported by topical treatment and nutritional support, resulted in the complete resolution of the skin lesions and spectacular improvement of the body condition in both cases...
September 11, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28807304/association-between-mast-cells-tissue-remodelation-and-parasite-burden-in-the-skin-of-dogs-with-visceral-leishmaniasis
#18
Jamille Mirelle de Oliveira Cardoso, Henrique Gama Ker, Rodrigo Dian de Oliveira Aguiar-Soares, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Bruno Mendes Roatt, Paula Melo de Abreu Vieira, Wendel Coura-Vital, Cláudia Martins Carneiro, Alexandre Barbosa Reis
Canine visceral leishmaniosis (CVL) is a zoonosis of major public health impact caused by organisms of the genus Leishmania which is transmitted to human and animals by phlebotomine sand flies. The skin is the first point of contact with Leishmania parasites for sandy fly vectors and it is considered an important reservoir compartment in infected dogs. The aim of this study was to determine the main histophatologic alterations in ear skin of dogs naturally infected by Leishmania infantum with different clinical status and different degrees of parasitism...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807297/cutaneous-leishmaniosis-in-naturally-infected-dogs-in-paran%C3%A3-brazil-and-the-epidemiological-implications-of-leishmania-viannia-braziliensis-detection-in-internal-organs-and-intact-skin
#19
Ellen de Souza Marquez, Edilene Alcântara de Castro, Luciene Biazono Nabut, Magda Clara Vieira da Costa-Ribeiro, Ludmilla Dela Coletta Troiano Araújo, Saloe Bispo Poubel, André Luiz Gonçalves, Mariza Fordellone Rosa Cruz, Ana Paula Millet Evangelista Dos Santos Trad, Rafael Andre Ferreira Dias, Italmar Teodorico Navarro, Vanete Thomaz-Soccol
Environmental changes have occurred over the years, altering the eco-epidemiological pattern of leishmaniosis in the State of Paraná, Brazil, involving the pillars of the cycle (parasite, vectors, reservoir, and environment) and their interaction. Much has been discussed about the dog's role as a reservoir of the Leishmania (Viannia) braziliensis Vianna, 1911 transmission cycle. However, this question remains unanswered. The purpose of this study was to investigate, using parasitological and molecular methods, different samples in eight naturally infected dogs from an endemic rural locality where only L...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28752261/leishmanicidal-effect-of-antiparasitic-photodynamic-therapy-appdt-on-infected-macrophages
#20
Susana de Oliveira, Evaristo João da Ordem Trahamane, Juliana Monteiro, Gustavo Pires Santos, Pedro Crugeira, Fernando Sampaio, Camila Oliveira, Manoel Barral Neto, Antônio Pinheiro
The aim of this study is to evaluate the effects of ApPDT (antiparasitic photodynamic therapy) on the interaction of Leishmania braziliensis with J774 macrophages, used as a photosensitizer, methylene blue associated with red laser. The tests are in triplicate and the samples divided into four groups: control, photosensitizer, laser, and ApPDT. The photosensitizer used was the methylene blue at concentration of 12.5 μg/mL. The parameters of the laser were λ = 660 nm, 40 mW, and 8.4 J/cm(2). Samples are analyzed by optical microscopy through the identification and counting of infected and uninfected macrophages, parasite load, infectivity, and infection index...
December 2017: Lasers in Medical Science
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