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Placental growth factor

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https://www.readbyqxmd.com/read/29027018/accelerated-growth-of-hemangioblastoma-in-pregnancy-the-role-of-proangiogenic-factors-and-upregulation-of-hypoxia-inducible-factor-hif-in-a-non-oxygen-dependent-pathway
#1
REVIEW
Yosef Laviv, Joshua L Wang, Matthew P Anderson, Ekkehard M Kasper
Hemangioblastomas (HBs) are benign, highly vascular tumors, often characterized by loss of function of the von Hippel-Lindau (vHL) gene. They are the most common central nervous system tumor observed in vHL syndrome. Loss of function of the vHL gene creates a "pseudo-hypoxic" state, causing overactivation of hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF)-related pathways. In some cases, HBs can rapidly increase in size during pregnancy to then present acutely, which most frequently occurs after the 20th gestational week...
October 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29025978/the-anti-vascular-endothelial-growth-factor-receptor-1-monoclonal-antibody-d16f7-inhibits-glioma-growth-and-angiogenesis-in-vivo
#2
Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Elena Bonanno, Manuel Scimeca, Pedro Miguel Lacal, Grazia Graziani
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor that does not play a relevant role in physiological angiogenesis in adults, while it is important in tumor angiogenesis. In high-grade glioma VEGFR-1 expression by tumor endothelium and neoplastic cells contributes to the aggressive phenotype. We recently generated an anti-VEGFR-1 monoclonal antibody (mAb) characterized by a novel mechanism of action, since it hampers receptor activation without interfering with ligand binding...
October 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29024947/human-trophoblast-derived-hydrogen-sulfide-stimulates-placental-artery-endothelial-cell-angiogenesis
#3
Dongbao Chen, Lin Feng, Jennifer K Hodges, Thomas J Lechuga, Honghai Zhang
Endogenous hydrogen sulfide (H2S), mainly synthesized by cystathionine β-synthase (CBS) and cystathionineγ-lyase (CTH), has been implicated in regulating placental angiogenesis; however, the underlying mechanisms are unknown. This study was to test a hypothesis that trophoblasts synthesize H2S to promote placental angiogenesis. Human choriocarcinoma-derived BeWo cells expressed both CBS and CTH proteins while the first trimester villous trophoblast-originated HTR-8/SVneo cells expressed CTH protein only. The H2S producing ability of BeWo cells was significantly inhibited by either inhibitors of CBS (CHH) or CTH (BCA) and that in HTR-8/SVneo cells was inhibited by CHH only...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29023811/placental-growth-factor-inhibition-targets-pulmonary-angiogenesis-and-represents-a-novel-therapy-for-hepatopulmonary-syndrome-in-mice
#4
Sarah Raevens, Anja Geerts, Annelies Paridaens, Sander Lefere, Xavier Verhelst, Anne Hoorens, Jo Van Dorpe, Tania Maes, Ken R Bracke, Christophe Casteleyn, Bart Jonckx, Thomas Horvatits, Valentin Fuhrmann, Hans Van Vlierberghe, Christophe Van Steenkiste, Lindsey Devisscher, Isabelle Colle
Hepatopulmonary syndrome (HPS) is a severe complication of cirrhosis with increased risk of mortality. Pulmonary microvascular alterations are key features of HPS, but underlying mechanisms are incompletely understood, and studies on HPS are limited to rats. Placental growth factor (PlGF), a pro-angiogenic molecule that is selectively involved in pathological angiogenesis, may play an important role in HPS development, however, its role has never been investigated. In this study, we validated an HPS model by common bile duct ligation (CBDL) in mice, investigated the kinetic changes in pulmonary angiogenesis and inflammation during HPS development, and provide evidence for a novel therapeutic strategy by targeting pathological angiogenesis...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29021781/cross-talk-between-adipose-tissue-and-placenta-in-obese-and-gestational-diabetes-mellitus-pregnancies-via-exosomes
#5
REVIEW
Nanthini Jayabalan, Soumyalekshmi Nair, Zarin Nuzhat, Gregory E Rice, Felipe A Zuñiga, Luis Sobrevia, Andrea Leiva, Carlos Sanhueza, Jaime Agustín Gutiérrez, Martha Lappas, Dilys Jane Freeman, Carlos Salomon
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Excess energy storage is predominantly regulated by the adipose tissue. Primarily made up of adipocytes, adipose tissue acts as the body's major energy reservoir...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29018059/involvement-of-leptin-in-the-molecular-physiology-of-the-placenta
#6
Malena Schanton, Julieta Lorena Maymó, Antonio Pérez-Pérez, Victor Sanchez-Margalet, Cecilia Varone
Leptin is a homeostatic regulator in the placenta where it promotes proliferation, protein synthesis and the expression of tolerogenic maternal response molecules such as HLA-G. Leptin also exerts an anti-apoptotic action in placenta controlling the expression of p53 master cell cycle regulator under different stress conditions. On the other hand, leptin is an integrative target of different placental stimuli. The expression of leptin in placenta is regulated by hCG, insulin, steroids, hypoxia, and many other growth hormones, suggesting that it might have an important endocrine function in the trophoblastic cells...
October 9, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29017154/screening-performance-of-placental-growth-factor-for-the-prediction-of-low-birth-weight-and-adverse-intrapartum-and-neonatal-outcomes-in-a-term-low-risk-population
#7
Larissa N Bligh, Ristan M Greer, Sailesh Kumar
INTRODUCTION: Fetuses who fail to reach their genetic growth potential are thought to have sub-optimal placental function. Low placental growth factor (PlGF) levels have been shown to be predictive of placentally mediated conditions, such as pre-eclampsia or fetal growth restriction. We investigated the screening performance of PlGF for the prediction of low birth weight (<10th centile for gestation) and adverse intrapartum and neonatal outcomes in apparently low-risk term pregnancies...
October 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28994098/the-impact-of-antiandrogen-flutamide-on-the-hypoxia-inducible-factor-1%C3%AE-and-vascular-endothelial-growth-factor-a-gene-and-protein-expression-in-the-pig-placenta-during-late-pregnancy
#8
Elzbieta Czaja, Iwona Wieciech-Rojkiewicz, Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Maria Słomczynska
INTRODUCTION: In contrast to estradiol action, little is known about androgen signaling in placental development. The purpose of this study was to evaluate the impact of diminished androgen action on hypoxia inducible factor 1α (HIF-1α) and vascular endothelial growth factor A (VEGFA) protein expression as well as their mRNAs in the structures of fetal and maternal parts of porcine placenta during late pregnancy. MATERIAL AND METHODS: Pregnant pigs were injected daily with antiandrogen flutamide, at a dose of 50 mg/kg body weight at different stages of pregnancy: between gestational days 83-89 (90 dpc) and 101-107 (108 dpc)...
October 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28992178/tadalafil-improves-l-ng-nitroarginine-methyl-ester-induced-preeclampsia-with-fetal-growth-restriction-like-symptoms-in-pregnant-mice
#9
Kento Yoshikawa, Takashi Umekawa, Shintaro Maki, Michiko Kubo, Masafumi Nii, Kayo Tanaka, Hiroaki Tanaka, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Kenji Ikemura, Masahiro Okuda, Kan Katayama, Takekazu Miyoshi, Hiroshi Hosoda, Ning Ma, Toshimichi Yoshida, Tomoaki Ikeda
BACKGROUND: We investigated the efficacy and mechanisms of tadalafil, a selective phosphodiesterase 5 inhibitor, in treating preeclampsia (PE) with fetal growth restriction (FGR) using L-NG-nitroarginine methyl ester (L-NAME)-induced PE with FGR in pregnant mice as our experimental model. METHODS: C57BL/6 mice were divided into 2 groups 11 days postcoitum (d.p.c.). A control group of dams (C dam) received 0.5% carboxymethylcellulose (CMC). A L-NAME-treated group received 1 mg/ml L-NAME dissolved in CMC...
August 3, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28991900/intra-individual-variability-and-circadian-rhythm-of-vascular-endothelial-growth-factors-in-subjects-with-normal-glucose-tolerance-and-type-2-diabetes
#10
Markolf Hanefeld, Katrin Engelmann, Dieter Appelt, Dirk Sandner, Ingo Weigmann, Xenia Ganz, Frank Pistrosch, Carsta Köhler, Antje Gasparic, Andreas L Birkenfeld
Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical methods and quality of diabetes control. So far only limited information exists on intraindividual fluctuations over longer periods and circadian rhythms...
2017: PloS One
https://www.readbyqxmd.com/read/28990078/increased-expression-of-high-mobility-group-box-protein-1-and-vascular-endothelial-growth-factor-in-placenta-previa
#11
Han Xie, Ping Qiao, Yi Lu, Ying Li, Yuping Tang, Yiying Huang, Yirong Bao, Hao Ying
Placenta previa is often associated with preterm delivery, reduced birth weight, a higher frequency of placental accreta and postpartum haemorrhage, and increased likelihood of blood transfusion. The present study aimed to examine the expression of high mobility group box protein 1 (HMGB1) in the placenta of women with or without placenta previa. The study group consisted of placental tissues obtained from women with or without placenta previa. The expression levels of HMGB1 and vascular endothelial growth factor (VEGF) were evaluated in the placental tissues using reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry...
October 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28986273/ite-suppresses-angiogenic-responses-in-human-artery-and-vein-endothelial-cells-differential-roles-of-ahr
#12
Yan Li, Kai Wang, Qing-Yun Zou, Yi-Zhou Jiang, Chi Zhou, Jing Zheng
Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor is involved in regulation of many essential biological processes including vascular development and angiogenesis. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is an AhR ligand, which regulates immune responses and cancer cell growth. However, the roles of the ITE/AhR pathway in mediating placental angiogenesis remains elusive. Here, we determined if ITE affected placental angiogenic responses via AhR in human umbilical vein (HUVECs) and artery endothelial (HUAECs) cells in vitro...
October 3, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28978981/galectin-1-as-a-novel-risk-factor-for-both-gestational-hypertension-and-preeclampsia-specifially-its-expression-at-a-low-level-in-the-second-trimester-and-a-high-level-after-onset
#13
Chikako Hirashima, Akihide Ohkuchi, Shiho Nagayama, Hirotada Suzuki, Kayo Takahashi, Manabu Ogoyama, Hironori Takahashi, Koumei Shirasuna, Shigeki Matsubara
Our aim was to evaluate whether the serum level of galectin-1 (Gal-1) at 18-24 and 27-31 weeks of gestation is a risk factor for predicting the later occurrence of not only preeclampsia (PE) but also gestational hypertension (GH). We measured serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and Gal-1 using an enzyme-linked immunosorbent assay in 81 and 73 normal pregnant women, 22 and 16 women with a later onset of GH, and 37 and 29 women with a later onset of PE at 18-24 and 27-31 weeks, respectively...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978515/late-gestation-maternal-dietary-methyl-donor-and-cofactor-supplementation-in-sheep-partially-reverses-protection-against-allergic-sensitization-by-iugr
#14
Amy L Wooldridge, Robert J Bischof, Hong Liu, Gary K Heinemann, Damien S Hunter, Lynne C Giles, Rebecca A Simmons, Yu-Chin Lien, Wenyun Lu, Joshua D Rabinowitz, Karen L Kind, Julie A Owens, Vicki L Clifton, Kathryn L Gatford
Perinatal exposures are associated with altered risks of childhood allergy. Human studies and our previous work suggest restricted growth in utero (IUGR) is protective against allergic disease. The mechanisms are not clearly defined but reduced fetal abundance and altered metabolism of methyl donors are hypothesized as possible underlying mechanisms. We therefore examined whether late gestation maternal dietary methyl donor and co-factor supplementation of the placentally-restricted (PR) sheep pregnancy would reverse allergic protection in progeny...
October 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28977597/tgf-%C3%AE-1-inhibits-human-trophoblast-cell-invasion-by-upregulating-connective-tissue-growth-factor-expression
#15
Jung-Chien Cheng, Hsun-Ming Chang, Peter C K Leung
Appropriate trophoblast invasion into the maternal endometrium is essential for successful human implantation and placentation. Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein that is expressed in the placenta. Interestingly, the CTGF expression levels in the placenta and serum from patients with severe preeclampsia or fetal growth restriction are higher than those from healthy controls. However, to date, the role of CTGF in the regulation of trophoblast cell invasion remains unclear...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28974256/exosomes-of-human-placenta-derived-mesenchymal-stem-cells-stimulate-angiogenesis
#16
Motohiro Komaki, Yuri Numata, Chikako Morioka, Izumi Honda, Masayuki Tooi, Naoki Yokoyama, Hirohito Ayame, Kengo Iwasaki, Atsuko Taki, Noriko Oshima, Ikuo Morita
BACKGROUND: The therapeutic potential of mesenchymal stem cells (MSCs) may be attributed partly to humoral factors such as growth factors, cytokines, and chemokines. Human term placental tissue-derived MSCs (PlaMSCs), or conditioned medium left over from cultures of these cells, have been reported to enhance angiogenesis. Recently, the exosome, which can transport a diverse suite of macromolecules, has gained attention as a novel intercellular communication tool. However, the potential role of the exosome in PlaMSC therapeutic action is not well understood...
October 3, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28972822/inhibition-of-tgf-%C3%AE-signaling-in-shed-enhances-endothelial-differentiation
#17
J G Xu, T Gong, Y Y Wang, T Zou, B C Heng, Y Q Yang, C F Zhang
Low efficiency of deriving endothelial cells (ECs) from adult stem cells hampers their utilization in tissue engineering studies. The purpose of this study was to investigate whether suppression of transforming growth factor beta (TGF-β) signaling could enhance the differentiation efficiency of dental pulp-derived stem cells into ECs. We initially used vascular endothelial growth factor A (VEGF-A) to stimulate 2 dental pulp-derived stem cells (dental pulp stem cells and stem cells from human exfoliated deciduous teeth [SHED]) and compared their differentiation capacity into ECs...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28971718/evaluation-of-the-relation-between-placental-weight-and-placental-weight-to-foetal-weight-ratio-and-the-causes-of-stillbirth-a-retrospective-comparative-study
#18
Norbert Pásztor, János Sikovanyecz, Attila Keresztúri, Zoltan Kozinszky, Gábor Németh
The aim of the present study was to evaluate the clinical importance of placental weight (PW) and placental weight to foetal weight (PW/FW) ratio according to maternal characteristics, pathological conditions in obstetrics and the causes of foetal death by category in stillbirths. The results of autopsies and placental histopathological examinations for 145 singleton stillbirths were reviewed retrospectively. Pathological features of the placenta were significantly associated with lower PW compared to the group with no pathological placental parameters (230 grams versus 295 grams, p = ...
October 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28971553/evaluation-of-fibroblast-growth-factor-activity-exerted-by-placental-extract-used-as-a-cosmetic-ingredient
#19
Kouhei Ito, Ryuji Yamada, Nobuki Matsumoto, Toru Imamura
BACKGROUND: The biological activities claimed for placental extract (PE) in its medical and cosmetic applications are largely assumed to be the combined effects of its various signaling molecules and nutritional constituents. But there are considerable uncertainties about this assumption. AIMS: To determine the specific biological activity of PE at a molecular level. METHODS: Fibroblast growth factor (FGF) activity was assessed based on the ability to induce proliferation of FGF receptor (FGFR)-overexpressing BaF3 cells...
October 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28967076/aflibercept-in-the-management-of-acute-retinal-necrosis-syndrome-related-macular-edema
#20
Leticia Ortega-Evangelio, Javier Navarrete-Sanchis, Basil K Williams, Juan Miguel Tomás-Torrent
PURPOSE: Acute retinal necrosis (ARN) is a panuveitis syndrome that may lead to severe complications such as cystoid macular edema (CME). There is no consensus about the best treatment. We report one case of CME secondary to ARN managed with intravitreal aflibercept. CASE REPORT: A 41-year-old woman with a history of successfully treated varicella-zoster virus-associated ARN developed an epiretinal membrane (ERM) and underwent pars plana vitrectomy, ERM removal, inner limiting membrane peel, and lensectomy...
September 14, 2017: European Journal of Ophthalmology
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