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Placental growth factor

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https://www.readbyqxmd.com/read/29674208/increased-serum-levels-of-sflt-1-plgf-ratio-in-preeclamptic-women-with-onset-at-32-weeks-compared-with-%C3%A2-32-weeks
#1
Hirotada Suzuki, Chikako Hirashima, Shiho Nagayama, Kayo Takahashi, Tatsuo Yamamoto, Shigeki Matsubara, Akihide Ohkuchi
OBJECTIVE: Our first aim was to construct gestational-age-specific reference ranges of serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), and the sFlt-1/PlGF ratio at 19-38 weeks of gestation. Our second aim was to compare the serum levels of sFlt-1, PlGF, and the sFlt-1/PlGF ratio in 81 women with PE which occurred at <32, 32-33, 34-35, and ≥36 weeks. METHOD: Serum levels of sFlt-1 and PlGF were measured by automated immunoassays (Elecsys sFlt-1 and Elecsys PlGF)...
March 19, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29674192/predictive-value-of-sflt-1-plgf-sflt-1-plgf-ratio-and-papp-a-for-late-onset-preeclampsia-and-iugr-between-32-and-37-weeks-of-pregnancy
#2
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29670333/upregulation-of-vascular-endothelial-growth-factor-receptor-1-contributes-to-sevoflurane-preconditioning-mediated-cardioprotection
#3
Bin Qian, Yang Yang, Yusheng Yao, Yanling Liao, Ying Lin
Purpose: Sevoflurane preconditioning (SPC) can provide myocardial protective effects similar to ischemic preconditioning. However, the exact mechanism of SPC remains unclear. Previous studies indicate that vascular endothelial growth factor receptor 1 (VEGFR-1) is involved in ischemic preconditioning-mediated cardioprotection. This study was designed to determine the significance of VEGFR-1 signaling in SPC-mediated cardioprotection. Materials and methods: Myocardial ischemia-reperfusion (I/R) rat model was established using the Langendorff isolated heart perfusion apparatus...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29666409/exposure-to-phthalate-an-endocrine-disrupting-chemical-alters-the-first-trimester-placental-methylome-and-transcriptome-in-women
#4
N M Grindler, L Vanderlinden, R Karthikraj, K Kannan, S Teal, A J Polotsky, T L Powell, I V Yang, T Jansson
Phthalates are known endocrine disruptors and associated with decreased fecundity, pregnancy loss, and adverse obstetrical outcomes, however the underlying mechanisms remain to be established. Environmental factors can influence gene expression and cell function by modifying epigenetic marks, impacting the developing embryo as well as future generations of offspring. The impact of phthalates on placental gene methylation and expression is largely unknown. We studied the effect of maternal phthalate exposure on the human placental DNA methylome and transcriptome...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29659962/low-dietary-folate-interacts-with-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-to-increase-incidence-of-developmental-delays-and-defects
#5
Karen E Christensen, Renata H Bahous, Wenyang Hou, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with increased birth defect risk, likely through reduced purine synthesis. Objective: We aimed to determine if the interaction of MTHFD1 synthetase deficiency and low folate intake increases developmental abnormalities in a mouse model for MTHFD1 R653Q...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659486/vascular-endothelial-growth-factor-a-exerts-diverse-cellular-effects-via-small-g-proteins-rho-and-rap
#6
REVIEW
Akio Shimizu, Dimitar P Zankov, Misuzu Kurokawa-Seo, Hisakazu Ogita
Vascular endothelial growth factors (VEGFs) include five molecules (VEGF-A, -B, -C, -D, and placental growth factor), and have various roles that crucially regulate cellular functions in many kinds of cells and tissues. Intracellular signal transduction induced by VEGFs has been extensively studied and is usually initiated by their binding to two classes of transmembrane receptors: receptor tyrosine kinase VEGF receptors (VEGF receptor-1, -2 and -3) and neuropilins (NRP1 and NRP2). In addition to many established results reported by other research groups, we have previously identified small G proteins, especially Ras homologue gene (Rho) and Ras-related protein (Rap), as important mediators of VEGF-A-stimulated signaling in cancer cells as well as endothelial cells...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29656983/prophylaxis-and-treatment-of-foetal-growth-restriction
#7
REVIEW
Aamod Nawathe, Anna L David
Foetal growth restriction (FGR) and associated placental pathologies such as pre-eclampsia and stillbirth arise in early pregnancy when inadequate remodelling of maternal spiral arteries leads to persistent high-resistance low-flow uteroplacental circulation. Current interventions concentrate on targeting the placental ischaemia-reperfusion injury and oxidative stress associated with an imbalance in angiogenic/anti-angiogenic factors. Recent meta-analyses confirm that aspirin modestly reduces the risk for small-for-gestational-age pregnancy in high-risk women...
February 23, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29651732/maternal-cadmium-levels-during-pregnancy-and-the-relationship-with-preeclampsia-and-fetal-biometric-parameters
#8
Fan Wang, Fengyun Fan, Lianyun Wang, Wen Ye, Qiong Zhang, Shuangshuang Xie
Preeclampsia, which is caused by multiple factors, still remains one of the most serious complications of pregnancy. This study was designed to determine cadmium levels in women with preeclampsia compared to those of normotensive women. In this case-control study, maternal blood, umbilical cord blood, and placental cadmium levels were measured by an inductively coupled plasma mass spectrometry system in 51 women presenting consecutively with preeclampsia and 51 normotensive pregnant women. Groups were matched for maternal age, parity, and gestational age...
April 12, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29642799/placental-defects-an-epigenetic-perspective
#9
Sharvari S Deshpande, Nafisa H Balasinor
Placenta, the first organ to be formed during gestation, plays a crucial role in intrauterine regulation of fetal growth and is involved in several functions during fetal development such as exchange of nutrients, wastes, and gases; protection against maternal immune rejection; and various metabolic and endocrine functions. Several studies have shown the regulation of epigenetic factors and the phenomenon of genomic imprinting in placentation and embryogenesis. Any gain or loss of imprint marks in the placenta has been shown to associate with severe placental defects which in turn affect both the mother and the growing fetus and can have long-term effects during adulthood...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29629873/a-maternally-sequestered-biopolymer-stabilized-vascular-endothelial-growth-factor-vegf-chimera-for-treatment-of-preeclampsia
#10
Omar C Logue, Fakhri Mahdi, Heather Chapman, Eric M George, Gene L Bidwell
BACKGROUND: Preeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology. One of these factors, soluble fms-like tyrosine kinase-1, is believed to sequester vascular endothelial growth factor (VEGF), leading to systemic endothelial dysfunction and hypertension. With the goal of targeting soluble fms-like tyrosine kinase-1 while simultaneously preventing fetal exposure to VEGF, we fused VEGF to elastin-like polypeptide, a biopolymer carrier that does not cross the placental barrier (ELP-VEGF)...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29627351/placental-growth-factor-informed-management-of-suspected-pre-eclampsia-or-fetal-growth-restriction-the-mapple-cohort-study
#11
Andrew Sharp, Lucy C Chappell, Gustaaf Dekker, Sanja Pelletier, Yves Garnier, Onur Zeren, Katharina M Hillerer, Thorsten Fischer, Paul T Seed, Mark Turner, Andrew H Shennan, Zarko Alfirevic
OBJECTIVES: Placental Growth Factor (PlGF) has been shown to be beneficial in diagnosing pre-eclampsia. We performed a prospective cohort study of revealed PlGF in standard clinical use in four teaching hospitals in UK, Germany, Austria and Australia. STUDY DESIGN: Clinical data from women with suspected pre-eclampsia or fetal growth restriction <35 weeks' gestation with revealed PlGF measurement were collected (MAPPLE study). MAIN OUTCOME MEASURES: Data were compared to the PELICAN study (PlGF concealed)...
March 26, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29626976/chronic-histiocytic-intervillositis-clinical-biochemical-and-radiological-findings-an-observational-study
#12
Lawrence Koby, Sarah Keating, Ann Kinga Malinowski, Rohan D'Souza
INTRODUCTION: Chronic histiocytic intervillositis (CHI) of the placenta although rare, has a high recurrence rate, is associated with serious adverse pregnancy outcomes and has no available treatment. This study aims to determine clinical, biochemical and radiological factors associated with CHI, to guide management of subsequent pregnancies. METHODS: This retrospective observational study included consecutive cases with a histopathologic diagnosis of CHI after 18 weeks of gestation, between 2001 and 2014, and no controls...
April 2018: Placenta
https://www.readbyqxmd.com/read/29623045/relaxin-deficiency-leads-to-uterine-artery-dysfunction-during-pregnancy-in-mice
#13
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618931/upregulated-vegfa-and-dll4-act-as-potential-prognostic-genes-for-clear-cell-renal-cell-carcinoma
#14
Xilong Wang, Jun Zhang, Yangyun Wang, Minqi Tu, Ying Wang, Guowei Shi
Purpose: As a typical hypervascular tumor, clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. This study was aimed to explore the prognostic genes for ccRCC, focusing on the roles of vascular endothelial growth factor A ( VEGFA ) and Delta-like ligand 4 ( DLL4 ) in the disease. Materials and methods: The mRNA-sequencing data of kidney renal clear cell carcinoma (KIRC) were obtained from The Cancer Genome Atlas (TCGA) database, including 469 tumor samples and 68 adjacent normal samples...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29615752/endothelial-indoleamine-2-3-dioxygenase-1-regulates-the-placental-vascular-tone-and-is-deficient-in-intrauterine-growth-restriction-and-pre-eclampsia
#15
Pablo Zardoya-Laguardia, Astrid Blaschitz, Birgit Hirschmugl, Ingrid Lang, Sereina A Herzog, Liudmila Nikitina, Martin Gauster, Martin Häusler, Mila Cervar-Zivkovic, Eva Karpf, Ghassan J Maghzal, Chris P Stanley, Roland Stocker, Christian Wadsack, Saša Frank, Peter Sedlmayr
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29610276/the-transcriptional-regulator-ccctc-binding-factor-limits-oxidative-stress-in-endothelial-cells
#16
Anna R Roy, Abdalla Ahmed, Peter V DiStefano, Lijun Chi, Nadiya Khyzha, Niels Galjart, Michael D Wilson, Jason E Fish, Paul Delgado Olguin
The CCCTC-binding factor (CTCF) is a versatile transcriptional regulator required for embryogenesis, but its function in vascular development or in diseases with a vascular component is poorly understood. Here, we found that endothelial Ctcf is essential for mouse vascular development and limits accumulation of reactive oxygen species (ROS). Conditional knockout of Ctcf in endothelial progenitors and their descendants affected embryonic growth, and caused lethality at embryonic day 10.5 owing to defective yolk sac and placental vascular development...
April 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29599925/a-porcine-placental-extract-prevents-steatohepatitis-by-suppressing-activation-of-macrophages-and-stellate-cells-in-mice
#17
Liang Xu, Naoto Nagata, Mayumi Nagashimada, Fen Zhuge, Yinhua Ni, Guanliang Chen, Junzo Kamei, Hiroki Ishikawa, Yasuhiko Komatsu, Shuichi Kaneko, Tsuguhito Ota
Nonalcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver. NAFLD is associated with hepatic inflammation and oxidative stress, resulting in nonalcoholic steatohepatitis (NASH) with advanced fibrosis. Placental extracts have been used to treat various chronic diseases due to their antioxidative effect. However, the effects of the extracts on the development of NASH have yet to be elucidated. Here, we demonstrated that supplementation with an oral porcine placental extract (PPE) attenuated lipid accumulation and peroxidation, insulin resistance, inflammatory and stress signaling, and fibrogenesis in the liver of NASH model mice fed a high-cholesterol and high-fat diet...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29588807/placental-surface-area-mediates-the-association-between-fgfr2-methylation-in-placenta-and-full-term-low-birth-weight-in-girls
#18
Fu-Ying Tian, Xi-Meng Wang, Chuanbo Xie, Bo Zhao, Zhongzheng Niu, Lijun Fan, Marie-France Hivert, Wei-Qing Chen
Background: Fibroblast growth factor receptor 2 ( FGFR2 ) gene encodes a protein of the fibroblast growth factor receptor family. FGFR2 gene expression is associated with the regulation of implantation process of placenta which plays a vital role in fetal growth. DNA methylation is widely known as a mechanism of fetal growth. However, it is unclear whether and how DNA methylation of FGFR2 gene in the placenta is associated with full-term low birth weight. This case-control study aims to explore the links between FGFR2 methylation in placenta and full-term low birth weight and to further examine the mediation effect of placental surface area on this association...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29587776/improved-prediction-of-gestational-hypertension-by-inclusion-of-placental-growth-factor-and-pregnancy-associated-plasma-protein-a-in-a-sample-of-ghanaian-women
#19
Edward Antwi, Kerstin Klipstein-Grobusch, Joyce L Browne, Peter C Schielen, Kwadwo A Koram, Irene A Agyepong, Diederick E Grobbee
BACKGROUND: We assessed whether adding the biomarkers Pregnancy Associated Plasma Protein-A (PAPP-A) and Placental Growth Factor (PlGF) to maternal clinical characteristics improved the prediction of a previously developed model for gestational hypertension in a cohort of Ghanaian pregnant women. METHODS: This study was nested in a prospective cohort of 1010 pregnant women attending antenatal clinics in two public hospitals in Accra, Ghana. Pregnant women who were normotensive, at a gestational age at recruitment of between 8 and 13 weeks and provided a blood sample for biomarker analysis were eligible for inclusion...
March 27, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29580120/placental-growth-factor-as-a-predictor-of-the-efficacy-of-tadalafil-treatment-for-fetal-growth-restriction
#20
Michiko Kubo-Kaneda, Hiroaki Tanaka, Shintaro Maki, Masafumi Nii, Takashi Umekawa, Kazuhiro Osato, Yuki Kamimoto, Eiji Kondo, Tomoaki Ikeda
PURPOSE: We recently demonstrated the efficacy of tadalafil treatment for fetal growth restriction (FGR). This study aimed to evaluate the utility of serum placental growth factor (PlGF) level for predicting the efficacy of tadalafil for the treatment of FGR. MATERIALS AND METHODS: The correlations between serum level of PlGF and fetal growth velocity were retrospectively assessed in nine pregnant women receiving tadalafil for FGR before 30 weeks' gestation. RESULTS: Median gestational age was 26 weeks (range 26-28 weeks), and median deviation of estimated fetal weight from standard weight was -2...
March 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
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