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https://www.readbyqxmd.com/read/28938238/impact-of-diabetes-mellitus-on-5-year-clinical-outcomes-in-patients-with-chronic-total-occlusion-lesions
#1
Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Min Suk Shim, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Diabetes mellitus (DM) is a major predictor of cardiovascular morbidity and mortality. However, there are limited data on the impact of DM in patients who have chronic total occlusion (CTO) lesion on long-term outcomes. PATIENTS AND METHODS: A total of 822 CTO patients who underwent coronary angiography, treated by either percutaneous coronary intervention or optimal medical therapy, were enrolled and divided into two groups: (i) diabetic group (n=363) and (ii) nondiabetic group (n=459)...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28937385/primary-classical-hodgkin-lymphoma-of-rectum-report-of-an-extremely-rare-case-and-review-of-the-literature
#2
Jayasudha Arundhathi Vasudevan, Rekha A Nair, K Rakul Nambiar
Hodgkin lymphoma (HL) commonly presents as nodal disease, but in a subset of cases, the disease primarily develops in extranodal sites. Primary classical HL of the gastrointestinal (GI) tract is an extremely rare occurrence. Primary nature of the disease is confirmed after a complete lymphoma work up including chest radiograph, computed tomography scan, peripheral blood, and bone marrow studies. Only a few cases of primary GI lymphomas with limited immunohistochemical or molecular confirmation have been reported in literature...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936943/modulation-of-the-gastrointestinal-microbiome-with-nondigestible-fermentable-carbohydrates-to-improve-human-health
#3
Edward C Deehan, Rebbeca M Duar, Anissa M Armet, Maria Elisa Perez-Muñoz, Mingliang Jin, Jens Walter
There is a clear association between the gastrointestinal (GI) microbiome and the development of chronic noncommunicable diseases, providing a rationale for the development of strategies that target the GI microbiota to improve human health. In this article, we discuss the potential of supplementing the human diet with nondigestible fermentable carbohydrates (NDFCs) to modulate the composition, structure, diversity, and metabolic potential of the GI microbiome in an attempt to prevent or treat human disease...
September 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28936110/a-working-paradigm-for-the-treatment-of-obesity-in-gastrointestinal-practice
#4
Andres Acosta, Michael Camilleri
Obesity is a chronic, relapsing, multi-factorial disease characterized by abnormal or excessive adipose tissue accumulation that may impair health and increase disease risks. Despite the ever-increasing prevalence and economic and societal burden, the current approaches to treat obesity are not standardized or generally effective. In this manuscript, we describe a current working paradigm developed by a consensus approach for the multidisciplinary treatment of obesity in the GI practice. Obesity should be managed as a continuum of care focusing on weight loss, weight loss maintenance and prevention of weight regain...
January 2017: Techniques in Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28934349/the-association-between-acute-graft-versus-host-disease-and-antimicrobial-peptide-expression-in-the-gastrointestinal-tract-after-allogeneic-stem-cell-transplantation
#5
Daniela Weber, Katrin Frauenschläger, Sakhila Ghimire, Katrin Peter, Isabella Panzer, Andreas Hiergeist, Markus Weber, Daniel Kutny, Daniel Wolff, Matthias Grube, Elisabeth Huber, Peter Oefner, Andre Gessner, Thomas Hehlgans, Wolfgang Herr, Ernst Holler
Intestinal microbiota disruption is associated with acute gastrointestinal (GI) Graft-versus-Host Disease (GvHD) and poor outcome after allogeneic stem cell transplantation (ASCT). Here, in a retrospective analysis of 200 patients undergoing ASCT at the Regensburg University Medical Center, we assessed the relative expression of Paneth cell antimicrobial peptides (AMPs), Human Defensins (HD) 5 and 6 and regenerating islet-derived 3α (Reg3α), in 292 human intestinal biopsies as well as Reg3α serum levels in relation to acute GI GvHD...
2017: PloS One
https://www.readbyqxmd.com/read/28932838/engineered-biomimetic-nanovesicles-show-intrinsic-anti-inflammatory-properties-for-the-treatment-of-inflammatory-bowel-diseases
#6
Claudia Corbo, Walter E Cromer, Roberto Molinaro, Naama E Toledano Furman, Kelly A Hartman, Enrica De Rosa, Christian Boada, Xin Wang, David C Zawieja, Marco Agostini, Francesco Salvatore, Bincy P Abraham, Ennio Tasciotti
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal (GI) tract. Currently, it is treated with immunosuppressant or biologics that often induce severe adverse effects. Thus, there is an urgent clinical need for more specific treatments. To provide a valid therapeutic tool for IBD therapy, in this work we developed biomimetic nanovesicles by manipulating leukocyte membranes to exploit mechanisms of T-cell recruitment during inflammation...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28932147/assessment-of-the-oral-health-status-of-asthmatic-children
#7
Abla Arafa, Salwa Aldahlawi, Adel Fathi
OBJECTIVES: To assess the oral health status and salivary composition in a group of children suffering from bronchial asthma. MATERIALS AND METHODS: The sample consisted of sixty asthmatic children, sixty healthy negative controls, and sixty healthy positive controls of both sexes with age ranging from 4 to 12 years old. The asthmatics were grouped according to disease severity into mild, moderate, or severe asthmatic. All the children were clinically examined to assess their dental caries experience (decayed, indicated for extraction, and filled primary tooth [def] and decayed-missing-filled permanent tooth [DMF]), dental erosion condition (tooth wear index), and gingival health condition (gingival index [GI])...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28931467/clinical-features-and-molecular-epidemiology-of-diarrheagenic-escherichia-coli-pathotypes-identified-by-fecal-gastrointestinal-multiplex-nucleic-acid-amplification-in-patients-with-cancer-and-diarrhea
#8
Andrew W Chao, Micah Bhatti, Herbert L DuPont, James P Nataro, Lily G Carlin, Pablo C Okhuysen
Diarrheagenic Escherichia coli (DEC) pathotypes with differing epidemiology and clinical features, are known causes of disease with worldwide occurrence. At a major cancer center in the U.S., we studied patients with cancer and diarrhea for whom a GI Biofire FilmArray multiplex GI panel (BFM) was performed. An enteropathogen was identified in 382 of 2017 (19%) samples distributed across 311 patients. Of these, 60/311(19%) were positive for DEC. Patients receiving hematopoietic stem cell transplants (HSCT) 29/60 (48%) or with a hematologic malignancy 17/60 (28%) accounted for the majority of DEC cases...
August 12, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28931034/primary-care-physicians-are-under-testing-for-celiac-disease-in-patients-with-iron-deficiency-anemia-results-of-a-national-survey
#9
Marisa Spencer, Adrienne Lenhart, Jason Baker, Joseph Dickens, Arlene Weissman, Andrew J Read, Seema Saini, Sameer D Saini
BACKGROUND: Iron deficiency anemia (IDA) is a common extra-intestinal manifestation of celiac disease (CD). Little is known about the frequency with which primary care physicians (PCPs) test for CD in patients with IDA. We aimed to describe how PCPs approach testing for CD in asymptomatic patients with IDA. METHODS: We electronically distributed a survey to PCPs who are members of the American College of Physicians. Respondents were asked whether they would test for CD (serologic testing, refer for esophagogastroduodenoscopy [EGD], or refer to GI) in hypothetical patients with new IDA, including: (1) a young Caucasian man, (2) a premenopausal Caucasian woman, (3) an elderly Caucasian man, and (4) a young African American man...
2017: PloS One
https://www.readbyqxmd.com/read/28928740/microbiome-derived-lipopolysaccharide-enriched-in-the-perinuclear-region-of-alzheimer-s-disease-brain
#10
Yuhai Zhao, Lin Cong, Vivian Jaber, Walter J Lukiw
Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechanics of these AD-relevant pathogenic signals are still not well understood. Here, we provide evidence that an intensely pro-inflammatory bacterial lipopolysaccharide (LPS), part of a complex mixture of pro-inflammatory neurotoxins arising from abundant Gram-negative bacilli of the human gastrointestinal (GI) tract, are abundant in AD-affected brain neocortex and hippocampus...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28925499/weekend-admission-and-mortality-for-gastrointestinal-disorders-across-england-and-wales
#11
S E Roberts, T H Brown, K Thorne, R A Lyons, A Akbari, D J Napier, J L Brown, J G Williams
BACKGROUND: Little has been reported on mortality following admissions at weekends for many gastrointestinal (GI) disorders. The aim was to establish whether GI disorders are susceptible to increased mortality following unscheduled admission on weekends compared with weekdays. METHODS: Record linkage was undertaken of national administrative inpatient and mortality data for people in England and Wales who were hospitalized as an emergency for one of 19 major GI disorders...
September 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28923294/fundamental-limit-of-alpha-synuclein-pathology-in-gastrointestinal-biopsy-as-a-pathologic-biomarker-of-parkinson-s-disease-comparison-with-surgical-specimens
#12
Chaewon Shin, Sung-Hye Park, Ji Young Yun, Jung Hwan Shin, Han-Kwang Yang, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Guangxun Shen, Yoon Kim, Han-Joon Kim, Beomseok Jeon
OBJECTIVE: Alpha-synuclein (AS) accumulation identified by immunohistochemistry (IHC) of gastrointestinal (GI) tract biopsies is considered as a potential pathologic biomarker for Parkinson's disease (PD). We compared AS IHC findings in biopsy specimens and surgically resected full-depth specimens to examine the reliability of GI tract biopsies. METHODS: We included patients with PD who had undergone operation of the GI tract for treatment of tumors. Controls were matched with age at operation, gender, and surgical resection site...
September 4, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28923057/postprandial-lipemia-factoring-in-lipemic-response-for-ranking-foods-for-their-healthiness
#13
REVIEW
Cintia Botelho Dias, Paul J Moughan, Lisa G Wood, Harjinder Singh, Manohar L Garg
One of the limitations for ranking foods and meals for healthiness on the basis of the glycaemic index (GI) is that the GI is subject to manipulation by addition of fat. Postprandial lipemia, defined as a rise in circulating triglyceride containing lipoproteins following consumption of a meal, has been recognised as a risk factor for the development of cardiovascular disease and other chronic diseases. Many non-modifiable factors (pathological conditions, genetic background, age, sex and menopausal status) and life-style factors (physical activity, smoking, alcohol and medication use, dietary choices) may modulate postprandial lipemia...
September 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28922257/endoscopic-and-histological-assessment-of-paediatric-inflammatory-bowel-disease-over-a-three-year-follow-up-period
#14
J J Ashton, Q Bonduelle, E Mossotto, T Coelho, A Batra, N A Afzal, B Vadgama, S Ennis, R M Beattie
OBJECTIVES: Discrepancies between Inflammatory bowel disease (IBD) endoscopic/histological extent are documented at diagnosis. It is unclear whether these differences persist through disease course, with potential impact on categorisation and management. We aimed to analyse the progression of disease over a 3-year period. METHODS: Patients aged < 17 years, diagnosed between 2010-2013 at Southampton Children's Hospital and followed-up for 3 years were eligible...
September 16, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28919145/outcomes-of-therapy-for-vulvar-manifestation-of-inflammatory-bowel-disease-in-adolescents
#15
Katherine E Debiec, Scott D Lee, Ghassan T Wahbeh, Anne-Marie Amies Oelschlager
BACKGROUND: Vulvar manifestations of inflammatory bowel disease (IBD) are variable in presentation and challenging to treat. We describe vulvar manifestations and treatment response in adolescent females with IBD. CASES: We identified six patients with vulvar manifestations of IBD and documented treatments by retrospective chart review. Vulvar symptoms occurred without gastrointestinal (GI) symptoms in one patient. For the remaining five patients, two had GI symptoms prior to the onset of vulvar symptoms (mean time difference 4...
September 14, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28918212/an-%C3%AE-glucosidase-inhibitor-could-reduce-t-wave-alternans-in-type-2-diabetes-patients
#16
Kazuo Eguchi, Takahiro Komori, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
BACKGROUND: We tested the hypothesis that an alpha-glucosidase inhibitor (α-GI), miglitol, is effective in protecting the cardiovascular system in type 2 diabetes mellitus (T2DM). METHODS: We studied 19 hospitalized heart disease patients with T2DM in whom we performed continuous glucose monitoring, Holter electrocardiogram, and ambulatory blood pressure (BP) monitoring simultaneously for 48h. The α-GI miglitol was administered for half of the study period by a cross-over fashion...
August 15, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28916815/programmed-death-ligand-1-pd-l1-expression-in-tumour-cell-and-tumour-infiltrating-lymphocytes-of-her2-positive-breast-cancer-and-its-prognostic-value
#17
Ahrong Kim, So Jeong Lee, Young Keum Kim, Won Young Park, Do Youn Park, Jee Yeon Kim, Chang Hun Lee, Gyungyub Gong, Gi Yeong Huh, Kyung Un Choi
Immunotherapy targeting PD-1/PD-L1 axis showed benefits in cancer. Prognostic significance of tumour infiltrating lymphocytes (TILs) has been determined. We evaluated PD-L1 protein expression in tumour cells and TILs, PD-L1 mRNA level and various histopathologic factors including TILs using 167 formalin-fixed paraffin embedded tissues and 39 fresh tissue of HER2-positive breast cancer. TILs level and PD-L1 expression in tumour cells and TILs were significantly correlated one another. PD-L1 positivity in tumour cells was associated with high histologic grade and high TILs level (p < 0...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916340/identification-of-potent-nonabsorbable-agonists-of-the-calcium-sensing-receptor-for-gi-specific-administration
#18
Steven M Sparks, Paul K Spearing, Caroline J Diaz, David J Cowan, Channa Jayawickreme, Grace Chen, Thomas J Rimele, Claudia Generaux, Lindsey T Harston, Shane G Roller
Modulation of gastrointestinal nutrient sensing pathways provides a promising a new approach for the treatment of metabolic diseases including diabetes and obesity. The calcium-sensing receptor has been identified as a key receptor involved in mineral and amino acid nutrient sensing and thus is an attractive target for modulation in the intestine. Herein we describe the optimization of gastrointestinally restricted calcium-sensing receptor agonists starting from a 3-aminopyrrolidine-containing template leading to the identification of GI-restricted agonist 19 (GSK3004774)...
September 7, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28915085/pooled-analysis-safety-profile-of-nivolumab-and-ipilimumab-combination-therapy-in-patients-with-advanced-melanoma
#19
Mario Sznol, Pier Francesco Ferrucci, David Hogg, Michael B Atkins, Pascal Wolter, Massimo Guidoboni, Celeste Lebbé, John M Kirkwood, Jacob Schachter, Gregory A Daniels, Jessica Hassel, Jonathan Cebon, Winald Gerritsen, Victoria Atkinson, Luc Thomas, John McCaffrey, Derek Power, Dana Walker, Rafia Bhore, Joel Jiang, F Stephen Hodi, Jedd D Wolchok
Purpose The addition of nivolumab (anti-programmed death-1 antibody) to ipilimumab (anti-cytotoxic T-cell lymphocyte-associated 4 antibody) in patients with advanced melanoma improves antitumor response and progression-free survival but with a higher frequency of adverse events (AEs). This cross-melanoma study describes the safety profile of the approved nivolumab plus ipilimumab regimen. Methods This retrospective safety review on data from three trials (phase I, II, and III) included patients with advanced melanoma who received at least one dose of nivolumab 1 mg/kg plus ipilimumab 3 mg/kg every 3 weeks × 4 and then nivolumab 3 mg/kg every 2 weeks until disease progression or unacceptable toxicity while following established guidelines for AE management...
September 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28914249/visual-pedagogy-and-probiotics-for-hearing-impaired-children-a-pilot-study
#20
Amrita Sujlana, Ruchika Goyal, Parampreet Pannu, Shireen Opal, Palki Bansal
CONTEXT: Oral health care for children with special needs remains largely unmet. It is important that we should focus on preventive strategies for special children to help curtail and prevent oral diseases. AIM: This study aimed to assess the effect of visual pedagogy and probiotic mouth rinse on the periodontal health of hearing impaired children. MATERIALS AND METHODOLOGY: The study cohort consisted of twenty children with hearing impairment (HI) and 20 age-matched healthy children...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
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