Marshall McKenna, Narendranath Epperla, Armin Ghobadi, Jieqi Liu, Aleksandr Lazaryan, Uroosa Ibrahim, Caron A Jacobson, Seema G Naik, Loretta Nastoupil, Sayan Mullick Chowdhury, Timothy J Voorhees, Miriam T Jacobs, Umar Farooq, Keren Osman, Adam J Olszewski, Sairah Ahmed, Andrew M Evens
The use of CD19 chimeric antigen receptor T-cell (CAR-T) therapy for relapsed/refractory solid organ transplantation (SOT)-related post-transplant lymphoproliferative disorder (PTLD) is not well studied. We conducted a multicentre, retrospective analysis of adults with relapsed/refractory SOT-associated PTLD. Among 22 relapsed/refractory SOT-PTLD patients, the pathology was monomorphic B cell. Prior SOTs included 14 kidney (64%), three liver (14%), two heart (9%), one intestinal (5%), one lung (5%), and one pancreas after kidney transplant (5%)...
May 2, 2023: British Journal of Haematology